Over 62% Carbon Patents (Class 424/122)
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Antimicrobial preparations, methods for preparing the same and uses thereof to combat microorganisms
Patent number: 10470459Abstract: The present invention provides antimicrobial preparations of crystalline particles of an antimicrobial agent, wherein said antimicrobial agent is an antimicrobial peptide or an antimicrobial polyene, methods for preparing the same and uses thereof to combat microorganisms. The invention further provides crystalline particles of the antimicrobial agent so obtained from the methods of the invention in isolated form and concentrated liquid preparations which comprise said crystalline particles. The invention still further provides the use of such isolated crystalline particles and concentrated liquid preparations to combat microorganisms.Type: GrantFiled: May 28, 2015Date of Patent: November 12, 2019Assignee: IPABC LTDInventor: Ulrich W. Schwarz -
Patent number: 10234470Abstract: The present invention discloses an enzyme-linked immunosorbent assay kit for detecting dinitolmide and use thereof. The enzyme-linked immunosorbent assay kit of the present invention comprises dinitolmide antibody and coating antigen and enzyme conjugate; wherein, the dinitolmide antibody is dinitolmide monoclonal antibody or dinitolmide polyclonal antibody; when the coating antigen is the conjugate of dinitolmide hapten and carrier protein, the enzyme conjugate is enzyme-labeled secondary antibody, or enzyme-labeled specific anti-dinitolmide monoclonal or polyclonal antibody; when the coating antigen is dinitolmide antibody or secondary antibody, the enzyme conjugate is enzyme-labeled dinitolmide hapten. The enzyme-linked immunosorbent assay kit has a simple structure, and it is convenient for use, cheap and portable. Its detection is high effective, accurate, and convenient. It can be used for on-site monitoring and is suitable for qualitative and quantitative screenings of a great number of samples.Type: GrantFiled: July 4, 2012Date of Patent: March 19, 2019Assignee: Beijing Kwinbon Biotechnology Co., Ltd.Inventors: Fangyang He, Yuping Wan, Caiwei Feng, Xiaoqin Luo, Jing Feng, Haifeng Cui, Nianqin Xu, Liangliang Zhu, Yumei Liu, Fangfang Jia, Zhengmiao Zhao
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Patent number: 9809832Abstract: The present invention relates to a method for microbial fermentation and biotransformation of aromatic acids to aromatic acids with reduced carbon atoms of wide commercial importance using a culture of actinomycete species. Amycolatopsis sp or the mutant thereof is employed in the present invention to convert natural as well as synthetic aromatic acids to reduced carbon aromatic acids with wide applications. The said culture in the disclosed invention is adapted to grow at 37-46° C. to achieve the biotransformation of aromatic acid to reduced carbon aromatic acid is accomplished at 37-46° C. to obtain a higher yield of the product.Type: GrantFiled: August 28, 2013Date of Patent: November 7, 2017Assignee: PRIVI BIOTECHNOLOGIES PRIVATE LIMITEDInventors: Mahendra M Yeole, Aparna Gala, Arvind M. Lali
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Patent number: 9757432Abstract: The present invention provides compositions and methods useful for treating cancers such as glioblastoma. SapC-DOPS was found to be synergistically effective at inducing cell death when administered in conjunction with rapamycin. SapC-DOPS/rapamycin combination therapy allows physicians to give lower doses of each drug and achieve better therapeutic efficacy. The compositions also allow for less toxicity and fewer off-target effects. Related methods and materials are also provided herein.Type: GrantFiled: November 14, 2013Date of Patent: September 12, 2017Assignees: Ohio State Innovation Foundation, University of CincinnatiInventors: Balveen Kaur, Jeffrey Wojton, Xiaoyang Qi
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Patent number: 8991387Abstract: Heating units, drug supply units and drug delivery articles capable of rapid heating are disclosed. Heating units comprising a substrate and a solid fuel capable of undergoing an exothermic metal oxidation reaction disposed within the substrate are disclosed. These heating units can be actuated by electrical resistance, by optical ignition or by percussion. Drug supply units and drug delivery articles wherein a solid fuel is configured to heat a substrate to a temperature sufficient to rapidly thermally vaporize a drug disposed thereon are also disclosed.Type: GrantFiled: March 4, 2013Date of Patent: March 31, 2015Assignee: Alexza Pharmaceuticals, Inc.Inventors: Ramesh Damani, Ron L. Hale, Daniel J. Myers, Reynaldo J. Quintana, Dennis W. Solas, Soonho Song, Pravin Soni, Curtis Tom, Krishnamohan Sharma
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Patent number: 8387612Abstract: Heating units, drug supply units and drug delivery articles capable of rapid heating are disclosed. Heating units comprising a substrate and a solid fuel capable of undergoing an exothermic metal oxidation reaction disposed within the substrate are disclosed. These heating units can be actuated by electrical resistance, by optical ignition or by percussion. Drug supply units and drug delivery articles wherein a solid fuel is configured to heat a substrate to a temperature sufficient to rapidly thermally vaporize a drug disposed thereon are also disclosed.Type: GrantFiled: June 16, 2009Date of Patent: March 5, 2013Assignee: Alexza Pharmaceuticals, Inc.Inventors: Ramesh Damani, Ron L. Hale, Daniel J. Myers, Reynaldo J. Quintana, Dennis W. Solas, Soonho Song, Pravin Soni, Curtis Tom, Kirshnamohan Sharma
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Patent number: 7964694Abstract: The invention relates to polysiloxanes of the general formula (I) [M?Dn]3T??(I), in which: M? is XSiY2O1/2 D is SiY2O2/2 T is SiZO3/2 and a process for the preparation thereof and their use as additives in aqueous surfactant-containing formulations.Type: GrantFiled: July 27, 2007Date of Patent: June 21, 2011Assignee: Evonik Goldschmidt GmbHInventors: Michael Ferenz, Sascha Herrwerth, Holger Leidreiter, Felix Mueller, Joerg Peggau
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Patent number: 6855524Abstract: The invention concerns a method for producing exopolysaccharides by fermenting micro-organisms characterised in that it consists in carrying out the fermentation in a nutrient medium comprising at least a source of carbon available to the micro-organisms and at least a source of nitrogen, said source being derived from a fraction of carob seed.Type: GrantFiled: September 6, 2000Date of Patent: February 15, 2005Assignee: Danisco USA Inc.Inventors: Olivier Nore, Jean-Luc Simon
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Patent number: 6509373Abstract: Disclosed is a new Streptomyces candidus strain, and relevant uses thereof.Type: GrantFiled: May 12, 2000Date of Patent: January 21, 2003Assignee: Development Center for BiotechnologyInventors: Ming Shiang, Mann Yan Kuo, Kuei Chih Chu, Pao Chi Chang, Hsiu Ying Chang, Hai Ping Lee
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Patent number: 6423337Abstract: The present invention relates to a porous structure of prepared fungal cell wall components, whereby the cell wall material is derived from a fungi selected from the division Zygomycota, the fungal material in the form of a suspension is subjected to drying in such a way that the material obtains a porous structure, the structure has a liquid absorbing property which is at least 15 ml/g of 1% NaCl (aq) and it has a liquid transporting ability of water, at a density of 0.01 to 0.03 g/cm3, in a horizontal direction of at least 10 mm during the first minute of absorption and in a vertical direction of at least 5 mm during a first minute of absorption.Type: GrantFiled: October 11, 2000Date of Patent: July 23, 2002Assignee: Lizyx ABInventor: Lars Edebo
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Patent number: 6193964Abstract: Disclosed is a new Streptomyces candidus strain, and relevant uses thereof.Type: GrantFiled: August 13, 1998Date of Patent: February 27, 2001Assignee: Development Center for BiotechnologyInventors: Ming Shiang, Mann Yan Kuo, Kuei Chih Chu, Pao Chi Chang, Hsiu Ying Chang, Hai Ping Lee
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Patent number: 5985325Abstract: This invention provides rapamycin solid dosage unit which comprises a core and a sugar overcoat, said sugar overcoat comprising rapamycin, one or more sugars, and one or more binders.Type: GrantFiled: May 29, 1998Date of Patent: November 16, 1999Assignee: American Home Products CorporationInventor: Arwinder S. Nagi
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Patent number: 5674484Abstract: A non-lymphoid continuous cell line adapted for propagation of avian coccidia is provided. This cell line is useful for the production of vaccine antigens for prophylactic treatment of poultry, particularly in a vaccine for coccidia.Type: GrantFiled: July 11, 1994Date of Patent: October 7, 1997Assignee: Pfizer Inc.Inventors: Timothy J. Miller, Robert A. Clare, Patricia Lufburrow
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Patent number: 5665728Abstract: This invention provides a method of preventing or treating hyperproliferative vascular disease in a mammal by administering an antiproliferative effective amount of rapamycin alone or in combination with mycophenolic acid.Type: GrantFiled: May 26, 1995Date of Patent: September 9, 1997Assignee: American Home Products CorporationInventors: Randall Ellis Morris, Clare Robert Gregory
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Patent number: 5646160Abstract: This invention provides a method of preventing or treating hyperproliferative vascular disease in a mammal by administering an antiproliferative effective amount of rapamycin alone or in combination with mycophenolic acid.Type: GrantFiled: May 26, 1995Date of Patent: July 8, 1997Assignee: American Home Products CorporationInventors: Randall Ellis Morris, Clare Robert Gregory
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Patent number: 5641485Abstract: Physiologically active caledothricins A-I and their salts, which are useful for the treatment of mycotic diseases. Also strains belonging to the genus Pseudomonas capable of producing the caledothricins upon cultivation.Type: GrantFiled: August 11, 1995Date of Patent: June 24, 1997Assignee: Hoffmann-La Roche Inc.Inventors: Masae Kikuchi, Hisao Shimada, Hitomi Tanaka
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Patent number: 5567676Abstract: The present invention concerns new antiobiotic substances demoninated de-acyl antibiotics A40926, de-acyl antibiotic A 40926P and antibiotic A 40926 amino glucronyl aglycon, and the use of these substances in the treatment of infectious diseases involving microorganisms susceptible to it.Type: GrantFiled: June 1, 1995Date of Patent: October 22, 1996Assignee: Gruppo Lepetit S.p.AInventors: Enrico Selva, Grazia Beretta, Angelo Borghi, Maurizio Denaro
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Patent number: 5563146Abstract: This invention provides a method of preventing or treating hyperproliferative vascular disease in a mammal by administering an antiproliferative effective amount of rapamycin alone or in combination with mycophenolic acid.Type: GrantFiled: May 26, 1995Date of Patent: October 8, 1996Assignee: American Home Products CorporationInventors: Randall E. Morris, Clare R. Gregory
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Patent number: 5561138Abstract: This invention provides a method of treating immune related anemia in a mammal which comprises administering rapamycin to said mammal orally, parenterally, intravascularly, intranasally, intrabronchially, transdermally, rectally.Type: GrantFiled: December 13, 1994Date of Patent: October 1, 1996Assignee: American Home Products CorporationInventor: Jay J. Armstrong
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Patent number: 5516686Abstract: The Antibiotic Complex AB-023 and its components: Antibiotic AB-023a and ibiotic AB-023b are disclosed, which are obtained by the controlled aerobic culture of Streptomyces sp. NCIMB 40212 in an aqueous nutrient culture substrate. Antibiotics AB-023 display a biological activity against pathogen fungi which attack agricultural crops and man.Type: GrantFiled: October 31, 1994Date of Patent: May 14, 1996Assignee: Ministero Dell `Universita` E Della Ricerca Scientifica E TecnologicaInventors: Rossella Bortolo, Dante Cidaria, Giorgio Cassani, Adriana Vallesi, Gianfranco Gugliemetti, Giorgio Borgonovi, Silvia Spera, Giorgio Pirali, Giovanni Confalonieri
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Patent number: 5460814Abstract: The present invention relates to the compound A of the formula (A), the related compound B, carboxylic acid derived from acid anhydride group of these compounds and esters and salts thereof, microorganisms for producing the compounds, methods for producing the compounds A and/or B by using the microorganisms, and a treated or untreated fermentation broth obtained by culturing strains belonging to genus Zopfiella or Zopfiella curvata No. 37-3 strain. ##STR1## The present invention provides the compounds A and B, derivatives thereof, and treated or untreated fermentation broth obtained by culturing the strains belonging to genus Zopfiella or Zopfiella curvata No. 37-3 strain, which show an excellent activities as antifungal agent and anti-thrombotic agent.Type: GrantFiled: April 18, 1994Date of Patent: October 24, 1995Assignee: Nissan Chemical Industries, Ltd.Inventors: Tsuneo Watanabe, Takeshi Yasumoto, Michio Murata, Michito Tagawa, Hiroyuki Narushima, Takashi Furusato, Masao Kuwahara, Masami Hanaue, Tatsuya Seki
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Patent number: 5456910Abstract: Novel antibiotic stalobacins A to I having physico-chemical properties as shown in Tables 1 to 4 are provided, which are excellent antibiotics showing marked effects on Gram-positive bacteria.Type: GrantFiled: May 17, 1994Date of Patent: October 10, 1995Assignee: Shionogi & Co., Ltd.Inventors: Shigeru Matsutani, Tadashi Yoshida, Ryuji Sakazaki, Koichi Matsumoto, Shigeo Yagi, Bunji Kageyama, Yoshimi Kawamura, Toshiyuki Kamigauchi, Susumu Kamata
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Patent number: 5455240Abstract: The present invention relates to compositions and methods for preventing pneumococcal infection. In particular, the invention relates to identification of the major reception for Streptococcus pneumoniae on activated human cells, and diagnostic and therapeutic compositions and methods based thereon. In particular, the invention relates to the discovery that platelet activating factor (PAF) receptor is an adhesive ligand for pneumococcal adherence to activated lung epithelial and venous endothelial (i.e., host) cells. Accordingly, the present invention is directed to a method for preventing or treating an infection with Streptococcus pneumoniae by administering an antagonist of platelet activating factor receptor. The invention further relates to recognition that adherence to activated cells also involves a carbohydrate ligand found on such activated cells.Type: GrantFiled: June 20, 1994Date of Patent: October 3, 1995Assignees: The Rockefeller University, Beth Israel Hospital AssociationInventors: Elaine I. Tuomanen, Diana R. Cundell, Norma P. Gerard
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Patent number: 5451403Abstract: Fermentation product A87689 is produced by a strain of Amycolatopsis mediterranei selected from NRRL 18815 and NRRL 18851, or an A87689-producing mutant thereof. A87689, its C.sub.1-6 -alkyl ether and C.sub.1-6 -alkanoyl ester derivatives and pharmaceutically acceptable salts thereof are phospholipase A.sub.2 inhibitors that are useful as antiinflammatory agents. Fermentation products known as BU-3889V, its components and pharmaceutically acceptable salts thereof, are phospholipase A.sub.2 inhibitors that are also useful as antiinflammatory agents.Type: GrantFiled: April 28, 1994Date of Patent: September 19, 1995Assignee: Eli Lilly and CompanyInventors: Dennis R. Berry, Anne H. Dantzig, Manuel Debono, Robert Hamill, R. Michael Molloy, Raymond C. Yao
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Patent number: 5431896Abstract: Described is a new immunosuppressant, L-687,819, a C-31 demethylated derivative of L-683,795 (FK-523), produced under fermentation conditions utilizing the new mutant microorganism, Streptomyces hygroscopicus subsp. ascomyceticus (Merck Culture Collection MA 6646) ATCC No. 53855, being a blocked mutant of Streptomyces hygroscopicus subsp. ascomyceticus (MA 6475) ATCC No. 14891. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.Type: GrantFiled: July 30, 1992Date of Patent: July 11, 1995Assignee: Merck & Co., Inc.Inventors: Louis Kaplan, Robert P. Borris, Kevin M. Byrne, Linda S. Wicker, Deborah L. Zink
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Patent number: 5397570Abstract: The Antibiotic Complex AB-023 and its components: Antibiotic AB-023a and ibiotic AB-023b are disclosed, which are obtained by the controlled aerobic culture of Streptomyces sp. NCIMB 40212 in an aqueous nutrient culture substrate. Antibiotics AB-023 display a biological activity against pathogen fungi which attack agricultural crops and man.Type: GrantFiled: October 15, 1993Date of Patent: March 14, 1995Assignee: Ministero Dell `Universita` E Della Ricerca Scientifica E TecnologicaInventors: Rossella Bortolo, Dante Cidaria, Giorgio Cassani, Adriana Vallesi, Gianfranco Gugliemetti, Giorgio Borgonovi, Silvia Spera, Giorgio Pirali, Giovanni Confalonieri
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Patent number: 5350579Abstract: Fermentation product A87689 is produced by a strain of Amycolatopsis mediterranei selected from NRRL 18815 and NRRL 18851, or an A87689-producing mutant thereof. A87689, its C.sub.1-6 -alkyl ether and C.sub.1-6 -alkanoyl ester derivatives and pharmaceutically acceptable salts thereof are phospholipase A.sub.2 inhibitors that are useful as antiinflammatory agents. Fermentation products known as BU-3889V, its components and pharmaceutically acceptable salts thereof, are phospholipase A.sub.2 inhibitors that are also useful as antiinflammatory agents.Type: GrantFiled: August 9, 1993Date of Patent: September 27, 1994Assignee: Eli Lilly and CompanyInventors: Dennis R. Berry, Anne H. Dantzig, Manuel Debono, Robert Hamill, R. Michael Molloy, Raymond C. Yao
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Patent number: 5346919Abstract: The present invention relates to the compound A of the formula (A), the related compound B, carboxylic acid derived from acid anhydride group of these compounds and esters and salts thereof, microorganisms for producing the compounds, methods for producing the compounds A and/or B by using the microorganisms, and a treated or untreated fermentation broth obtained by culturing strains belonging to genus Zopfiella or Zopfiella curvata No. 37-3 strain. ##STR1## The present invention provides the compounds A and B, derivatives thereof, and treated or untreated fermentation broth obtained by culturing the strains belonging to genus Zopfiella or Zopfiella curvata No. 37-3 strain, which show an excellent activities as antifungal agent and anti-thrombotic agent.Type: GrantFiled: August 2, 1993Date of Patent: September 13, 1994Assignee: Nissan Chemical Industries, Ltd.Inventors: Tsuneo Watanabe, Takeshi Yasumoto, Michio Murata, Michito Tagawa, Hiroyuki Narushima, Takashi Furusato, Masao Kuwahara, Masami Hanaue, Tatsuya Seki
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Patent number: 5306496Abstract: Novel antibiotics NK374186A, NK374186B, NK374186B3 and NK374186C3 having antibacterial, antineoplastic, immunomodulation, and liver regeneration promoting activities are provided.NK374186A, NK374186B, NK374186B3 and NK374186C3 are obtained by culturing NK374186 strain (FERM P-12285) (FERM-BP 3870) belonging to the genus Penicillium. NK374186A is a compound represented by a rational formula of C.sub.34 H.sub.61 N.sub.3 O.sub.12 S.sub.9 and having a molecular weight of M+ 735 (FD-MS m/z); NK374186B is a compound represented by a rational formula of C.sub.34 H.sub.61 N.sub.3 O.sub.9 and having a molecular weight of M+ 655 (FD-MS m/z); NK374186B3 is a compound represented by a rational formula of C.sub.34 H.sub.61 N.sub.3 O.sub.9 and having a molecular weight of M+ 655 (FD-MS m/z); and NK374186C3 is a compound represented by a rational formula of C.sub.32 H.sub.59 N.sub.3 O.sub.7 and having a molecular weight of M+ 597 (FD-MS m/z).Type: GrantFiled: June 10, 1992Date of Patent: April 26, 1994Assignee: Nippon Kayaku Kabushiki KaishaInventors: Tomio Morino, Masakazu Nishimoto, Mituyuki Nishide, Akira Masuda, Masatoshi Yamada, Eiji Kawano, Takaaki Nishikiori, Seiichi Saito
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Patent number: 5296597Abstract: The present invention is directed towards a series of secondary and tertiary amide derivatives of Partricin A & Partricin B attached at the C-18 carboxyl group. The compounds can be used in the treatment of hypercholesteremia and hyperlipemia conditions, of steroidal imbalances, and as antifungal and antiprotozoan agents.Type: GrantFiled: November 14, 1990Date of Patent: March 22, 1994Assignee: SPA Societa' Prodotti Antibiotici S.P.A.Inventors: Tiberio Bruzzese, Franco Ottoni, Giuseppe Ghielmetti
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Patent number: 5288711Abstract: This invention provides a method of preventing or treating hyperproliferative vascular disease in a mammal by administering an antiproliferative effective amount of a combination of rapamycin and heparin.Type: GrantFiled: April 28, 1992Date of Patent: February 22, 1994Assignee: American Home Products CorporationInventors: Robert D. Mitchell, Stephen Skwish
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Patent number: 5279829Abstract: An Antibiotic Complex AB-023 and its components: Antibiotic AB-023a and Abiotic AB-023b are disclosed, which are obtained by the controlled aerobic culture of Streptomyces sp. NCIMB 40212 in an aqueous nutrient culture substrate. Antibiotic AB-023 displays a biological activity against pathogen fungi which attack agricultural crops and man.Type: GrantFiled: August 19, 1991Date of Patent: January 18, 1994Assignee: Ministero Dell `Universita` e Della Ricerca Scientifica e TecnologicaInventors: Rossella Bortolo, Dante Cidaria, Giorgio Cassani, Adriana Vallesi, Gianfranco Guglielmetti, Giorgio Borgonovi, Silvia Spera, Giorgio Pirali, Giovanni Confalonieri
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Patent number: 5278064Abstract: Fermentation product A87689 is produced by a strain of Amycolatopsis mediterranei selected from NRRL 18815 and NRRL 18851, or an A87689-producing mutant thereof. A87689, its C.sub.1-6 -alkyl ether and C.sub.1-6 -alkanoyl ester derivatives and pharmaceutically acceptable salts thereof are phospholipase A.sub.2 inhibitors that are useful as antiinflammatory agents. Fermentation products known as BU-3889V, its components and pharmaceutically acceptable salts thereof, are phospholipase A.sub.2 inhibitors that are also useful as antiinflammatory agents.Type: GrantFiled: May 4, 1992Date of Patent: January 11, 1994Assignee: Eli Lilly and CompanyInventors: Dennis R. Berry, Anne H. Dantzig, Manuel Debono, Robert Hamill, R. Michael Molloy, Raymond C. Yao
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Patent number: 5275817Abstract: Novel physiologically active substance, kanglemycin C, having a molecular weight of 326 and is isolated from the fermentation broth of Nocardia mediterranei var. kanulensis 1747-64 which belongs to the genus Nocardia. Kanglemycin C has an immunosuppressive activity and inhibits proliferation of tumor cells in vitro.Type: GrantFiled: February 21, 1992Date of Patent: January 4, 1994Assignee: Nippon Kayaku Kabushiki KaishaInventors: Wang Nanjin, Yang Xianshu
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Patent number: 5239064Abstract: A novel antibiotic complex, A59770, individual factors and derivatives thereof, are provided. The A59770 compounds are useful as pesticides, particularly as rodenticides. Further provided are methods for reducing a rodent population, rodenticidal compositions, and an A59770-producing Amycolatopsis orientalis culture.Type: GrantFiled: April 11, 1990Date of Patent: August 24, 1993Assignee: Eli Lilly and CompanyInventors: Marvin M. Hoehn, Karl H. Michel, Raymond C. Yao
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Patent number: 5206018Abstract: This invention provides a method of treating, inhibiting the proliferation of, reducing the size of, or eradicating malignant neoplasms in a mammal in need thereof which comprises administering an antineoplastic amount of rapamycin to said mammal. In particular, rapamycin is useful in treating, inhibiting the proliferation of, reducing the size of, or eradicating malignant mammary and skin carcinomas, and central nervous system neoplasms.Type: GrantFiled: October 29, 1991Date of Patent: April 27, 1993Assignee: Ayerst, McKenna & Harrison, Inc.Inventors: Surendra N. Sehgal, Claude Vezina
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Patent number: 5169956Abstract: This invention relates to new agents designated LL-F28249.alpha., LL-F28249.beta., LL-F28249.gamma., LL-F28249.delta., LL-F28249.epsilon., LL-F28249.zeta., LL-F28249.eta., LL-F28249.theta., LL-F28249.iota., LL-F28249.kappa., LL-F28249.lambda., LL-F28249.mu., LL-F28249.nu., and LL-F2924.omega., to their production by fermentation, to methods for their recovery and concentration from crude solutions, to processes for their purification and to pharmaceutically and pharmacologically-acceptable salts thereof. The present invention includes within its scope the biologically pure culture which produces there agents, derived from a newly-discovered and previously uncultured microorganism, Streptomyces cyaneogriseus subsp. noncyanogenus, NRRL 15773.Type: GrantFiled: June 25, 1990Date of Patent: December 8, 1992Assignee: American Cyanamid CompanyInventors: Guy T. Carter, Margaret J. Torrey, Michael Greenstein
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Patent number: 5126265Abstract: The AB-021 Antibiotics and the main components thereof: AB-021a Antibiotic and AB-021b Antibiotic, obtained by means of the controlled aerobial cultivation of Streptomyces sp. NCIB 40068 in an aqueous nutrient cultivation medium, are disclosed.The AB-021 Antibiotics show a biological activity against pathogenous fungi of agrarian cultivations, of human pathogenous fungi and of bacteria.Type: GrantFiled: November 27, 1989Date of Patent: June 30, 1992Assignee: Presidenza del Consiglio dei Ministri-Ufficio del Ministro per il coordinamento delle Iniziative per la Ricerca Scientifica e TecnologicaInventors: Dante Cidaria, Nunzio Andriollo, Giorgio Cassani, Enrico Crestani, Silvia Spera, Carlo Garavaglia, Giorgio Pirali, Giovanni Confalonieri
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Patent number: 5116815Abstract: A novel substance having anthelmintic activity, the PF 1022 substance, which is produced by cultivating a fungal strain capable of producing the substance and recovering the substance from the culture.Type: GrantFiled: February 6, 1990Date of Patent: May 26, 1992Assignee: Meiji Seika Kaisha Ltd.Inventors: Masayuki Takagi, Tadaaki Okada, Naotoshi Akai, Takashi Yaguchi, Shinji Miyadoh, Takashi Shomura, Toru Sasaki, Masaji Sezaki, Takao Shimizu, Masashi Niida
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Patent number: 5080899Abstract: This invention provides a method of preventing or reversing pulmonary inflammation in a mammal by administering an effective amount of rapamycin orally, parenterally, intranasally, or intrabronchially. As such, rapamycin is useful in providing the symptomatic relief of diseases in which pulmonary inflammation is a component such as, asthma, chronic obstructive pulmonary disease, emphysema, acute respiratory distress syndrome, bronchitis, and the like.Type: GrantFiled: February 22, 1991Date of Patent: January 14, 1992Assignee: American Home Products CorporationInventors: Robert J. Sturm, Laurel M. Adams, Barry M. Weichman
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Patent number: 5078999Abstract: This invention provides a method of treating systemic lupus erythematosus in a mammal in need thereof which comprises administering an effective amount of rapamycin orally, parenterally, intranasally, intrabronchially, or rectally.Type: GrantFiled: February 22, 1991Date of Patent: January 7, 1992Assignee: American Home Products CorporationInventors: Linda M. Warner, Laurel M. Adams
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Patent number: 5073369Abstract: The present invention relates to the use of microbiologically prepared compounds and their mixtures, which are called efomycins, as performance promoters in farm animals and processes for their preparation, and furthermore new efomycins and their mixtures as new chemical compounds. The invention also relates to microorganisms which can be used for the preparation of the efomycins and their mixtures.Type: GrantFiled: March 17, 1986Date of Patent: December 17, 1991Assignee: Bayer AktiengesellschaftInventors: Klaus Frobel, Erwin Bischoff, Hartwig Muller, Olga Salcher, Anno De Jong, Friedrich Berschauer, Martin Scheer
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Patent number: 5066493Abstract: Methods of using rapamycin in the treatment of cancers or tumors are disclosed.Type: GrantFiled: April 9, 1991Date of Patent: November 19, 1991Assignee: American Home Products CorporationInventors: Surendra N. Sehgal, Claude Vezina
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Patent number: 5034224Abstract: This invention relates to a method and composition for the control of protozoal infections in warm-blooded animals by orally administering to said animals an effective amount of a new antibacterial produced in a microbiological fermentation under controlled conditions using a new subspecies of Micromonospora citera and mutants thereof. The antibacterial designated LL-E19085.alpha. is a highly effective anticoccidial agent especially useful for the prophylactic, pharmaceutical, and therapeutic treatment of poultry and other animals raised for meat production.Type: GrantFiled: May 30, 1989Date of Patent: July 23, 1991Assignee: American Cyanamid CompanyInventors: Sidney Kantor, Robert L. Kennett, Jr., deceased
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Patent number: 5032404Abstract: The present invention involves a liposomal agent for treating disseminated fungal infection in an animal. This liposomal agent comprises a variety of polymer antifungal compounds, particularly hamycin. These antifungal compounds are encapsulated within a liposome decreasing toxicity. This liposome is preferably a stable multilamellar vesicle. The method of administration is preferably parenteral, but may be oral or topical.Type: GrantFiled: February 23, 1989Date of Patent: July 16, 1991Assignee: Board of Regents, The University of Texas SystemInventors: Gabriel Lopez-Berestein, Reeta Mehta
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Patent number: 5026547Abstract: A novel compound having an intense insecticidal activity and a process for producing the same which comprises culturing a strain belonging to the genus Humicola and isolating the compound from the culture.Type: GrantFiled: November 9, 1989Date of Patent: June 25, 1991Assignee: Meiji Seika Kaisha, Ltd.Inventors: Kei-ichi Imamura, Shuichi Gomi, Michiaki Iwata, Shinji Miyadoh, Masaru Shimura, Takashi Shomura, Masaji Sezaki, Shigeharu Inoye
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Patent number: 4968493Abstract: This invention provides a method for treating chronic respiratory disease, fowl cholera and necrotic enteritis in infected birds, by orally administering thereto a pharmaceutically effective amount of antibiotic LL-E19020.alpha., antibiotic LL-E19020.beta. or a physiologically acceptable salt thereof.Type: GrantFiled: June 19, 1989Date of Patent: November 6, 1990Assignee: American Cyanamid CompanyInventors: Guy T. Carter, Michael Greenstein, Joseph J. Goodman, Donald B. Borders, William M. Maiese, Raymond T. Testa
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Patent number: 4960694Abstract: A test reagent for detecting fibrin monomers in blood, comprises an antibiotic of a pyrrole amidine series as a precipitant, introduced in a buffer solution. A method of detecting fibrin monomers in blood, comprises the steps of mixing venous blood with an anticoagulant, centrifuging the mixture of the venous blood with the anticoagulant, removing a citrate plasma, using an antibiotic of a pyrrole amidine series as a precipitant, and evaluating a precipitation reaction which takes place thereby.Type: GrantFiled: July 9, 1987Date of Patent: October 2, 1990Inventors: Klaus Eckardt, Gottfried Toepfer, Andreas Seifert, Manfred Schulze, Udo Funke, Marlena Stepanauskas, deceased, by Leonas-Vitas Stepanauskas, legal representative, Daina Stepanauskas, legal representative, Heinz Thrum, deceased, by Margot Thrum, legal representative, by Matthias Thrum, legal representative, by Michael Thrum, legal representative
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Patent number: 4954438Abstract: This invention relates to a process for preparing an antibiotic D788-7 wherein, after culturing carborubicin-producing bacteria, the obtained culture liquid is extracted in acidic conditions while stirring to be absorbed to synthetic resin, followed by desorption from the resin and elution with acetone and the resulting acetone solution containing carborubicin is converted into an antibiotic D788-7 by photo radiation, for obtaining D788-7 in the purified form from the reaction solution. The production yield for D788-7 is extremely high and its use as an antitumor agent can be made possible.Type: GrantFiled: August 21, 1989Date of Patent: September 4, 1990Assignee: Sanraku IncorporatedInventors: Akihiro Yoshimoto, Osamu Jodo, Yoshio Watanabe, Rokuro Okamoto, Tomio Takeuchi
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Patent number: 4950477Abstract: This invention concerns a method of preventing a pulmonary infection by a fungus in a subject susceptible to infection by the fungus comprising administering to the subject an amount per dose in an aerosol spray of a polyene or a pharmaceutically acceptable derivative thereof, effective to prevent pulmonary infection by the fungus. This invention further discloses a method of treating pulmonary aspergillosis in a subject comprising administering to the subject an amount per dose in an aerosol spray of a polyene, e.g., amphotericin B or pimaricin, or a pharmaceutically acceptable derivative thereof effective to treat aspergillosis.Type: GrantFiled: August 23, 1988Date of Patent: August 21, 1990Assignee: Memorial Hospital For Cancer and Allied DieseasInventors: Heinz J. Schmitt, Donald Armstrong, Edward M. Bernard