Over 62% Carbon Patents (Class 424/122)
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Patent number: 4247542Abstract: A-40104 antibiotic complex, comprising active factors A, B, C, and D, produced by submerged aerobic fermentation of Clitopilus pseudo-pinsitus. Individual factors A, B, and C have been isolated. A-40104 factor C is the known antibiotic pleuromutilin. A-40104 factors A and B are novel antibiotics related to pleuromutilin. A-40104 factor A, the major new factor, is the D-xylose acetal derivative of pleuromutilin. A-40104 factors A and B, their 19,20-dihydro derivatives and the per(C.sub.2 -C.sub.6)alkanoyl derivatives of factors A and B and of their 19,20-dihydro derivatives are active against gram-positive and gram-negative bacteria, anaerobic bacteria, and Mycoplasma.Type: GrantFiled: June 22, 1978Date of Patent: January 27, 1981Assignee: Eli Lilly and CompanyInventors: Karl H. Michel, Calvin E. Higgens
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Patent number: 4237117Abstract: The present invention is concerned with a method for the treatment of benign prostatic hypertrophy in male humans, comprising administering an effective amount of a compound selected from the group consisting of partricin, C.sub.1 -C.sub.6 alkyl ester of partricin and C.sub.1 -C.sub.6 alkyl ester of N-mono- and N,N-disubstituted partricin, the N-substituents being C.sub.1 -C.sub.6 alkyl or carboxylic acyl, to a human male suffering from benign prostatic hypertrophy.Type: GrantFiled: October 5, 1979Date of Patent: December 2, 1980Assignee: Spa-Societa Prodotti Antibiotici S.p.A.Inventors: Tiberio Bruzzese, Lorenzo Ferrari
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Patent number: 4235883Abstract: A BN-213 substance-producing strain of the genus Pseudomonas is cultivated to produce BN-213 substance in a culture medium. The BN-213 substance is isolated from the culture medium and purified, and proved to be a novel antibiotic.Type: GrantFiled: October 12, 1978Date of Patent: November 25, 1980Assignee: Meiji Seika Kaisha LimitedInventors: Jiro Itoh, Shinji Miyadoh, Mitsugu Itoh, Norio Ezaki, Tomizo Niwa, Yujiro Yamada
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Patent number: 4230692Abstract: Ravidomycin is produced by culturing Streptomyces ravidus NRRL 11,300 in an aqueous nutrient medium. Ravidomycin is useful as an antibacterial agent. Methods for its preparation and use are disclosed.Type: GrantFiled: November 3, 1978Date of Patent: October 28, 1980Assignee: Ayerst McKenna & Harrison, Inc.Inventors: Surendra N. Sehgal, Claude Vezina
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Patent number: 4226879Abstract: The present invention relates to a new composition designated as AM-1042 or asukamycin. AM-1042 has an antibiotic activity upon Gram-positive bacteria and Eimeria, and its acute toxicity (LD.sub.50 ' ip.) in mice was 48.5 mg./kg. AM-1042 has an excellent therapeutical effect on various infectious diseases caused by a parasite of Gram-positive bacteria and Eimeria. AM-1042 has been confirmed to be distinguishable from known antibiotics such as e.g. amicetin B, azomycin and manumycin. AM-1042 is produced by fermentation of a microorganism belonging to the genus Streptomyces and capable of producing AM-1042. A composition capable of preventing and curing coccidiosis of poultry containing AM-1042 as active ingredient.Type: GrantFiled: September 1, 1978Date of Patent: October 7, 1980Assignees: Kyowa Hakko Kogyo Kabushiki Kaisha, The Kitasato InstituteInventors: Satoshi Omura, Chiaki Kitao, Akira Nakagawa, Haruo Tanaka, Juichi Awaya, Ruiko Oiwa
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Patent number: 4224314Abstract: A species of Nocardia, designated Nocardia argentinensis Huang ATCC 31438, when subjected to aerobic submerged fermentation, produces an antibiotic complex containing as its major component antibiotic Compound 51,467. Methods for the recovery and purification of antibiotic Compound 51,467 and minor antibiotic components, Compounds 52,726 and 52,748, and some of their properties are outlined.Type: GrantFiled: March 2, 1979Date of Patent: September 23, 1980Assignee: Pfizer Inc.Inventors: Walter D. Celmer, Paul C. Watts, Walter P. Cullen, Liang H. Huang, Riichiro Shibakawa, Junsuke Tone
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Patent number: 4209509Abstract: Substance SF-1739 derivatives, Substance SF-1739 HP, Substance SF-1739 HP-C, Substance SF-1739 HP-F, Substance SF-1739 HP-3 and Substance SF-1739 HP-5, the physico-chemical properties of which derivatives are described in the specification; processes for preparing such SF-1739 derivatives; and antimicrobial compositions containing at least one of the said Substance SF-1739 derivatives.Type: GrantFiled: February 1, 1979Date of Patent: June 24, 1980Assignee: Meiji Seika Kaisha Ltd.Inventors: Shigeharu Inouye, Takashi Shomura, Michio Kojima, Takashi Hisamatsu
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Patent number: 4202886Abstract: An antibiotic SF-1942 substance produced by cultivating an SF-1942 substance producing strain of the genus Streptomyces in a nutrient medium under aerobic conditions to produce and accumulate the SF-1942 substance in the nutrient medium and isolating the SF-1942 substance from the fermentation broth followed by purification and a process for the production of the antibiotic SF-1942 substance. The SF-1942 substance is effective as an antimicrobial agent and an antitumor agent against Sarcoma 180 tumor cells in mice.Type: GrantFiled: May 2, 1978Date of Patent: May 13, 1980Assignee: Meiji Seika Kaisha, Ltd.Inventors: Kazunori Ohba, Takashi Shomura, Yasuaki Ogawa, Takashi Tsuruoka, Hiroshi Watanabe, Takashi Hisamatsu, Shingo Uchida, Michio Kojima, Shigeharu Inouye
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Patent number: 4195079Abstract: A new polycyclic ether antibiotic produced by a strain of Actinomadura verrucosospora under submerged fermentation conditions is useful in controlling coccidiosis in poultry and in improving feed utilization efficiency in ruminants.Type: GrantFiled: January 31, 1979Date of Patent: March 25, 1980Assignee: Pfizer Inc.Inventors: Walter D. Celmer, Walter P. Cullen, John R. Oscarson, Liang H. Huang, Riichiro Shibakawa, Junsuke Tone
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Patent number: 4192864Abstract: The present invention is concerned with a method for the treatment of dyslipidaemia and arteriosclerosis in human beings, comprising administering an effective amount of an active compound selected from the group consisting of partricin, alkyl esters of partricin and alkyl esters of N-mono- or disubstituted partricin to a human being in need of said treatment. If desired, the active compound can be administered in the form of a water-soluble complex with a compound selected from the group consisting of benzalkonium chloride, sodium lauryl sulphate, sodium tetradecyl sulphate, sodium desoxycholate and sodium dehydrocholate.Type: GrantFiled: May 30, 1978Date of Patent: March 11, 1980Assignee: Prospa N.V.Inventors: Tiberio Bruzzese, Lorenzo Ferrari
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Patent number: 4191825Abstract: The present invention relates to diacyloxyacids derived from the antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATCC No. 25532), and to processes for their production. The diacyloxyacids derivatives of acid S of this invention are useful as antifungal and antibacterial agents.Type: GrantFiled: October 5, 1978Date of Patent: March 4, 1980Assignee: Warner-Lambert CompanyInventors: David T. Connor, Samuel M. Ringel, Sidney Roemer, Maximillian von Strandtmann
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Patent number: 4187292Abstract: The present invention relates to antibiotics C-14919 E-1 and E-2 produced by cultivating a microorganism of the genus Nocardia. These antibiotics display a wide activity against e.g. Gram-positive bacteria, fungi and yeast and are useful as germicides or disinfectants.Type: GrantFiled: July 12, 1977Date of Patent: February 5, 1980Assignee: Takeda Chemical Industries, Ltd.Inventors: Eiji Higashide, Mitsuko Asai, Toru Hasegawa
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Patent number: 4181715Abstract: A novel antibiotic substance SF-1540 and a process for preparing the same which comprises culturing a substance SF-1540-producing microorganism belonging to the genus Streptomyces in a medium and isolating and recovering the substance SF-1540 from a cultured broth; a novel derivative of the substance SF-1540 and a process for preparing the same which comprises treating said antibiotic substance SF-1540 with methanol to form the corresponding antibiotic substance SF-1540 derivative.Type: GrantFiled: May 24, 1978Date of Patent: January 1, 1980Assignee: Meiji Seika Kaisha Ltd.Inventors: Yasumitsu Kondo, Takashi Shomura, Hiroshi Watanabe, Tetsuro Watanabe, Shigeharu Inouye, Taro Niida
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Patent number: 4169889Abstract: An antibiotic BN-200 substance produced by cultivating a BN-200 substance strain of the genus Erwinia and a process for producing the BN-200 substance.Type: GrantFiled: October 4, 1978Date of Patent: October 2, 1979Assignee: Meiji Seika Kaisha, Ltd.Inventors: Shoichi Amano, Shinji Miyadoh, Mitsugu Itoh, Norio Ezaki, Eiichi Akita, Yujiro Yamada
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Patent number: 4150152Abstract: A new polycyclic ether antibiotic produced by a strain of Streptomyces hygroscopicus under submerged fermentation conditions is useful in controlling coccidiosis in poultry and in improving feed utilization efficiency in ruminants.Type: GrantFiled: October 26, 1977Date of Patent: April 17, 1979Assignee: Pfizer Inc.Inventors: Walter D. Celmer, Walter P. Cullen, Charles E. Moppett, John R. Oscarson, Liang H. Huang, Riichiro Shibakawa, Junsuke Tone
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Patent number: 4148882Abstract: New polycyclic ether antibiotics produced by a species of actinomycete under submerged fermentation conditions are useful in controlling coccidiosis in poultry and in improving feed utilization efficiency in ruminants.Type: GrantFiled: June 24, 1977Date of Patent: April 10, 1979Assignee: Pfizer Inc.Inventors: Walter D. Celmer, Walter P. Cullen, Charles E. Moppett, John R. Oscarson, Liang H. Huang, Riichiro Shibakawa, Junsuke Tone
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Patent number: 4148883Abstract: A new species of Nocardia, designated Nocardia argentinensis Huang sp. nov., when subjected to aerobic submerged fermentation, produces a mixture of new antibiotics. Methods for the recovery and purification of these antibiotics are described and some of their antimicrobial properties are outlined.Type: GrantFiled: August 18, 1977Date of Patent: April 10, 1979Assignee: Pfizer Inc.Inventors: Walter D. Celmer, Walter P. Cullen, Charles E. Moppett, Mark T. Jefferson, Liang H. Huang, Riichiro Shibakawa, Junsuki Tone
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Patent number: 4143141Abstract: A method for the topical treatment of acne with antibiotic A-201A and A-201A compositions for acne are disclosed.Type: GrantFiled: September 14, 1977Date of Patent: March 6, 1979Assignee: Eli Lilly and CompanyInventors: Paul W. Ensminger, Robert L. Hamill
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Patent number: 4138550Abstract: The present invention relates to diacyloxyacids derived from the antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATCC No. 25532), and to processes for their production. The diacyloxyacids derivatives of acid S of this invention are useful as antifungal and antibacterial agents.Type: GrantFiled: February 4, 1977Date of Patent: February 6, 1979Assignee: Warner-Lambert CompanyInventors: David T. Connor, Samuel M. Ringel, Sidney Roemer, Maximillian Von Strandtmann
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Patent number: 4133876Abstract: Antibiotic A-32887 is produced by submerged aerobic fermentation of Streptomyces albus NRRL 11109. A-32887 is an antibacterial, antiprotozoal, anticoccidial, and insecticidal agent. A-32887 also increases feed-utilization efficiency in ruminants.Type: GrantFiled: May 31, 1977Date of Patent: January 9, 1979Assignee: Eli Lilly and CompanyInventors: Robert L. Hamill, Marvin M. Hoehn
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Patent number: 4132779Abstract: This disclosure describes a new antibiotic designated BL580 ZETA produced in a microbiological fermentation under controlled conditions using a new strain of Streptomyces hygroscopicus and mutants thereof. This new antibiotic is an active anticoccidial agent.Type: GrantFiled: June 20, 1977Date of Patent: January 2, 1979Assignee: American Cyanamid CompanyInventors: Martin R. Hertz, John H. E. J. Martin
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Patent number: 4132778Abstract: Antibiotic A-32887 is produced by submerged aerobic fermentation of Streptomyces albus NRRL 11109. A-32887 is an antibacterial, antiprotozoal, anticoccidial, and insecticidal agent. A-32887 also increases feed-utilization efficiency in ruminants.Type: GrantFiled: October 3, 1977Date of Patent: January 2, 1979Assignee: Eli Lilly and CompanyInventors: Robert L. Hamill, Marvin M. Hoehn
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Patent number: 4110436Abstract: Newly-discovered antibiotic A-28086 factor D, produced by submerged aerobic fermentation of Streptomyces aureofaciens NRRL 8092, is an antibacterial and anticoccidial agent and also increases feed-utilization efficiency in ruminant animals.Type: GrantFiled: January 26, 1977Date of Patent: August 29, 1978Assignee: Eli Lilly and CompanyInventors: Walter M. Nakatsukasa, Robert L. Hamill
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Patent number: 4110435Abstract: Newly-discovered antibiotic A-28086 factor D, produced by submerged aerobic fermentation of Streptomyces aureofaciens NRRL 8092, is an antibacterial and anticoccidial agent and also increases feed-utilization efficiency in ruminant animals.Type: GrantFiled: January 26, 1977Date of Patent: August 29, 1978Assignee: Eli Lilly and CompanyInventors: Walter M. Nakatsukasa, Robert L. Hamill
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Patent number: 4107297Abstract: The present invention relates to a new compound designated as AM-2282, having antibiotic activity and pharmacological activity, and a process of preparing same.Type: GrantFiled: November 28, 1977Date of Patent: August 15, 1978Assignee: The Kitasato InstituteInventors: Satoshi Omura, Yuzuru Iwai, Atsushi Hirano
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Patent number: 4107429Abstract: The present invention relates to 1-nor-2-amino carbamates derived from the antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATCC No. 25532), and to processes for their production. The 1-nor-2-amino carbamates of acid S of this invention are useful as antifungal agents.Type: GrantFiled: February 4, 1977Date of Patent: August 15, 1978Assignee: Warner-Lambert CompanyInventors: David T. Connor, Samuel M. Ringel, Maximilian VON Strandtmann
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Patent number: 4102997Abstract: A novel mixture of degradation products of boromycin is prepared by treating boromycin with acid. This mixture of compounds has anticoccidial activity and is useful for controlling cecal and/or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with animal sustenance.Type: GrantFiled: November 22, 1976Date of Patent: July 25, 1978Assignee: Merck & Co., Inc.Inventors: Irving Putter, Lucille J. Cole
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Patent number: 4098998Abstract: The present invention relates to aldehyde, oxime and phenylhydrazone derivatives of the novel antibiotic substance, acid S, produced by the organism Polyangium cellulosum var. fulvum (ATCC No. 25532) and to processes for their preparation. The aldehyde, oxime and phenylhydrazone derivatives of acid S of this invention are useful as antifungal agents.Type: GrantFiled: February 4, 1977Date of Patent: July 4, 1978Assignee: Warner-Lambert CompanyInventors: David T. Connor, Samuel M. Ringel, Maximillian Von Strandtmann
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Patent number: 4081532Abstract: A new polycyclic ether antibiotic produced by three strains of a new species of Dactylosporangium under submerged fermentation conditions is useful in controlling coccidiosis in poultry and in improving feed utilization efficiency in ruminants.Type: GrantFiled: September 20, 1976Date of Patent: March 28, 1978Assignee: Pfizer Inc.Inventors: Walter D. Celmer, Walter P. Cullen, Charles E. Moppett, John B. Routien, Mark T. Jefferson, Riichiro Shibakawa, Junsuke Tone
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Patent number: 4076940Abstract: A process for the conversion of the major antifungal antibiotic, acid S (ATCC NO. 25532) isolated from the fermentation of Polyangium cellulosum var. fulvum into the minor antibiotic, acid F, from the same fermentation is described wherein acid S is methylated with diazomethane to provide acid S methyl ester which is then oxidized with silver carbonate on celite to obtain the corresponding keto ester S, which is subsequently reduced with sodium borohydride to give a mixture of acid S methyl ester and acid F methyl ester. These esters are readily separated by preparative thin layer chromatography and the acid F methyl ester is hydrolyzed with sodium hydroxide solution to provide acid F.Type: GrantFiled: May 5, 1977Date of Patent: February 28, 1978Assignee: Warner-Lambert CompanyInventors: David T. Connor, Maximilian VON Strandtmann
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Patent number: 4076802Abstract: A new antibiotic substance X-4357B is obtained by culturing a strain of Streptomyces and recovering said substance from the fermentation mixture. The new substance possesses fungicidal, larvicidal and cytotoxic activities.Type: GrantFiled: March 30, 1977Date of Patent: February 28, 1978Assignee: Hoffmann-La Roche Inc.Inventor: John Westley
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Patent number: 4071631Abstract: There is disclosed a new antibiotic A21A which is produced by cultivating the microorganism, Streptomyces filipinensis, in aqueous nutrient medium. The antibiotic has growth-improving activity.Type: GrantFiled: October 29, 1976Date of Patent: January 31, 1978Assignee: Merck & Co., Inc.Inventors: Sheldon B. Zimmerman, John H. Chalmers, Jr.
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Patent number: 4069316Abstract: This invention provides a method for producing Antibiotic T-42082 wherein the method comprises cultivating an Antibiotic T-42082-producing strain of the genus Streptomyces (ATCC 31080) to permit said strain to elaborate and accumulate Antibiotic T-42082 in the resultant broth and harvesting the antibiotic from said broth. This invention also includes the novel antibiotic.Type: GrantFiled: November 1, 1976Date of Patent: January 17, 1978Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Imada, Yukimasa Nozaki, Toru Hasegawa, Masahiko Yoneda
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Patent number: 4062945Abstract: A new polycyclic ether antibiotic with anticoccidial, insecticidal and antimicrobial activity, its production by fermentation and methods for its recovery and purification are described.Type: GrantFiled: March 1, 1976Date of Patent: December 13, 1977Assignee: Pfizer Inc.Inventors: Walter D. Celmer, Walter P. Cullen, Charles E. Moppett, John R. Oscarson, John R. Routien
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Patent number: 4048304Abstract: A new polycyclic ether antibiotic with anticoccidial, insecticidal and antimicrobial activity, its production by fermentation and methods for its recovery and purification are described.Type: GrantFiled: March 1, 1976Date of Patent: September 13, 1977Assignee: Pfizer Inc.Inventors: Walter D. Celmer, Walter P. Cullen, Charles E. Moppett, John R. Oscarson, John B. Routien
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Patent number: 4038382Abstract: The present invention provides a process for the preparation of alkyl esters of polyene antibiotics, wherein a polyene antibiotic is reacted with a diazoalkane in the presence of a basic substance.The present invention also provides, as new materials, alkyl esters of polyene antibiotics in which the alkyl radical of the ester grouping contains 2 or more carbon atoms.Type: GrantFiled: November 11, 1975Date of Patent: July 26, 1977Assignee: SPA-Societe Prodotti Antibiotici S.p.A.Inventors: Tiberio Bruzzese, Rodolfo Ferrari
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Patent number: 4038384Abstract: Antibiotic A-28086 complex, comprising microbiologically active, structurally related factors A, B, and D, produced by submerged aerobic fermentation of Streptomyces aureofaciens NRRL 5758. Individual factors A, B, and D are separated and isolated by chromatography. The A-28086 antibiotics are antibacterial, antifungal, antiviral, anti-PPLO, anticoccidial, insecticidal and acaricidal agents and also increase feed-utilization efficiency in ruminants.Type: GrantFiled: April 21, 1975Date of Patent: July 26, 1977Assignee: Eli Lilly and CompanyInventors: David H. Berg, Robert L. Hamill, Marvin M. Hoehn
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Patent number: 4035481Abstract: Antibiotic A-28086 complex, comprising microbiologically active, structurally related factors A, B, and D, produced by submerged aerobic fermentation of Streptomyces aureofaciens NRRL 5758. Individual factors A, B, and D are separated and isolated by chromatography. The A-28086 antibiotics are antibacterial, antifungal, antiviral, anti-PPLO, anticoccidial, insecticidal and acaricidal agents and also increase feed-utilization efficiency in ruminants.Type: GrantFiled: May 10, 1976Date of Patent: July 12, 1977Assignee: Eli Lilly and CompanyInventors: David H. Berg, Robert L. Hamill, Marvin M. Hoehn
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Patent number: 4027014Abstract: A new antibiotic designated BN-130 substance is now provided, which has antibacterial activity against gram-negative and gram-positive bacteria as well as acid-fast bacteria. BN-130 substance is produced by cultivating a strain of Pseudomanas stutzeri under aerobic conditions.Type: GrantFiled: April 14, 1975Date of Patent: May 31, 1977Assignee: Meiji Seika Kaisha, Ltd.Inventors: Norio Ezaki, Shoichi Amano, Shinji Miyado, Mitsugu Ito, Chuhei Nojiri, Takashi Tsuruoka, Yujiro Yamada, Taro Niida
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Patent number: 4025654Abstract: A dry chelocardin salt composition which is stable to extended storage periods comprises a mixture of monosodium chelocardin and between 0.2 and 2.0 parts of sodium citrate.Type: GrantFiled: December 17, 1975Date of Patent: May 24, 1977Assignee: Abbott LaboratoriesInventor: Bahram Farhadieh
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Patent number: 4022885Abstract: A new polycyclic ether antibiotic with anticoccidial, insecticidal and antimicrobial activity, its production by fermentation and methods for its recovery and purification are described.Type: GrantFiled: February 10, 1975Date of Patent: May 10, 1977Assignee: Pfizer Inc.Inventors: Walter D. Celmer, Walter P. Cullen, Charles E. Moppett, John R. Oscarson, John B. Routien
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Patent number: 4017603Abstract: The present invention provides a water-soluble pharmaceutical complex, comprising the antibiotic partricin and/or an alkyl ester thereof and sodium desoxycholate and/or sodium dehydrocholate.Type: GrantFiled: August 29, 1975Date of Patent: April 12, 1977Assignee: SPA-Societa Prodotti Antibiotici S.p.A.Inventors: Rodolfo Ferrari, Ernani Dell'Acqua
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Patent number: 4016257Abstract: The present invention relates to cyclic and acyclic amide derivatives of the antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATTC No. 25532), to the acetates thereof and to processes for the production of the amides and their corresponding diacetates. The amide derivatives of acid S of this invention are useful as antifungal and antibacterial agents.Type: GrantFiled: August 7, 1975Date of Patent: April 5, 1977Assignee: Warner-Lambert CompanyInventors: David T. Connor, Samuel M. Ringel, Maximilian VON Strandtmann
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Patent number: 4014994Abstract: The present invention is concerned with a new and improved process for the recovery of the polyene antibiotic partricin, wherein a surface-active agent is added to a fermented liquor containing partricin in an amount sufficient to bring the partricin into solution, whereafter insoluble material is removed and the partricin is recovered from the aqueous solution.Type: GrantFiled: August 29, 1975Date of Patent: March 29, 1977Assignee: SPA-Societa Prodotti Antibiotici S.p.A.Inventors: Sergio Magnaghi, Eustorgio Felci, Rodolfo Ferrari
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Patent number: 4012284Abstract: 1. A process for the preparation of a new antibiotic F.I. 1762, which comprises cultivating the Streptomyces 1762 under aerobic conditions in a liquid nutrient medium containing a carbon source, a nitrogen source and mineral salts, at a temperature between 25.degree. and 37.degree. C, over a period of time from 3 to 7 days, and extracting the formed antibiotic from the fermentation broth at a pH between 8 and 9 by means of a water-immiscible solvent, isolating and purifying the antibiotic F.I. 1762.Type: GrantFiled: October 6, 1964Date of Patent: March 15, 1977Assignee: Societa' Farmaceutici Italia, S.p.A.Inventors: Aurelio Di Marco, Graziana Canevazzi, Arpad Grein, Piergiuseppe Orezzi, Marcello Gaetani
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Patent number: 4009261Abstract: The present invention relates to 7-substituted triol derivatives of the novel antibiotic substance, acid S, produced by the organism Polyangium cellulosum var. fulvum (ATCC No. 25532) and to processes for their preparation. The 7-substituted triol derivatives of acid S of this invention are useful as antifungal agents.Type: GrantFiled: August 7, 1975Date of Patent: February 22, 1977Assignee: Warner-Lambert CompanyInventors: David T. Connor, Samuel M. Ringel, Maximilian VON Strandtmann
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Patent number: 4001398Abstract: The present invention describes octahydro and decahydro derivatives of the novel antibiotic substance, acid S, produced by the organism Polyangium cellulosum var. fulvum (ATCC No. 25532) and to processes for their preparation. The octahydro and dechydro derivatives of acid S of this invention are useful as antifungal and antibacterial agents.Type: GrantFiled: June 24, 1974Date of Patent: January 4, 1977Assignee: Warner-Lambert CompanyInventors: David T. Connor, Samuel M. Ringel, Sidney Roemer, Maximilian VON Strandtmann
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Patent number: 3995027Abstract: A method for moderating the effects of viral infections in animals by administration thereto of a polyether ionophorous antibiotic selected from the group consisting of monensin, A-28086, A28695, A28695A, A28695B, nigericin, and carbomonensin.Type: GrantFiled: June 4, 1975Date of Patent: November 30, 1976Assignee: Eli Lilly and CompanyInventors: Charles Gale, Larry R. McDougald
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Patent number: RE29244Abstract: Compositions containing the antibiotic having the designation X-537A, useful for the treatment and prevention of coccidiosis in poultry feed compositions containing the antibiotic and methods of treating coccidiosis are disclosed.Type: GrantFiled: July 2, 1976Date of Patent: May 31, 1977Assignee: Hoffmann-La Roche Inc.Inventor: Julius Berger
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Patent number: RE30339Abstract: A process for the conversion of the major antifungal antibiotic, acid S (ATCC No. 25532) isolated from the fermentation of Polyangium cellulosum var. fulvum into the minor antibiotic, acid F, from the same fermentation is described wherein acid S is methylated with diazomethane to provide acid S methyl ester which is then oxidized with silver carbonate on celite to obtain the corresponding keto ester S, which is subsequently reduced with sodium borohydride to give a mixture of acid S methyl ester and acid F methyl ester. These esters are readily separated by preparative thin layer chromatography and the acid F methyl ester is hydrolyzed with sodium hydroxide solution to provide acid F.Type: GrantFiled: July 14, 1978Date of Patent: July 15, 1980Assignee: Warner-Lambert CompanyInventors: David T. Connor, Maximilian von Strandtmann