Abstract: The present invention relates to an active oxygen scavenging agent and a cancer chemopreventing agent both comprising a dried Grifola, a dry Grifola powder and/or a Grifola extract, and to a food or animal feed comprising the active oxygen scavenging agent or the cancer chemopreventing agent.

Abstract: The present invention refers to extracts from the fungus Guignardia sp., and also a new isolate compound from the aforementioned extract, both having antimicrobial activities, particularly antibacterial and antifungal activities, and their use in pharmaceutical compositions. The new compound, isolated from the extract of the fungus Guignardia sp.

Abstract: The invention provides an extract of the Pleurotus genus such as Pleurotus eryngii (DC. et Fr) Quél to prevent and treat hypertension, and enhance cardiovascular health. Further, the invention provides pharmaceutical compositions containing the extract as an active ingredient, in a pharmaceutically or therapeutically acceptable carrier. The invention also provides a method of preventing and treating hypertension by administration of the extract. Further, there is provided a method for preparing the extract and evaluating the extract using in vitro or in vivo tests to ensure antihypertensive activity.

Abstract: Preventive and therapeutic agents against the HIV virus and pathogenic bacteria, comprising the active ingredients obtained from hyphae of Kabanoanatake [scientific name: Fuscoia obliqua (Fr.) Aoshima].

Abstract: In view of an acknowledgement that keeping a healthy body is a fundamental matter for overcoming cancer, it is an object of the present invention to provide composition containing well-balanced nutrition, having an effect to suppress the mutagenesis substances, having no sub-action even if the composition is continued to be taken as nutritious supplemental substance and capable of promoting healthy state. There are provided a nutritious supplemental composition for suppression against large intestinal cancer and its manufacturing method in which dietary fiber in a range of 15 wt % to 30 wt % in respect to a total amount of composition is contained in the dried koji fine powder including dead fungi of Aspergillus while keeping a capability of catalysis of groups of enzyme produced by Aspergillus.

Abstract: The present invention provides herbal compositions that can prevent or reduce the severity, intensity, or duration of allergic and/or asthmatic symptoms and/or can prevent or delay the development of an allergic or asthmatic response to an antigen. The compositions may optionally include one or more adjuvants, cytokines, encapsulating materials, or pharmaceutical carriers or excipients, and may be administered prior to, during, or after the development of allergic or asthmatic symptoms in sensitized individuals. Alternatively or additionally, the compositions may be administered prior to sensitization to a particular antigen; preferably substantially concurrently with exposure to the antigen.

Abstract: Species of fungi have been identified, which can be used to control coleopteran infestations of host plants. The fungi are particularly useful for controlling infestations of Diaprepes abbreviatus.

Abstract: A pharmaceutical or medicinal preparation which comprises a mixture of the following seven herbs: Tinospora cordifolia, Aloa vera (Aloa barbedensis), Curcuma longa, Withania somnifera, Achyranthus aspera, Ocimum sanctum and picorrhiza kurroa, or a mixture of the active ingredients that have been extracted from those herbs or chemically synthesised. The herbal formulation of the invention is effective for the treatment of cancer, in particular haematological malignancies.

Abstract: The present invention relates to biologically active material, containing mainly polysaccharides, from the solution culturing for mycelium of Antrodia camphorata, a kind of mushroom that only grows inside a unique Taiwanese plant called Cinnamomum kanehirae tree, being able to improve immunity and resist tumors and parasites, and the preparation and compositions for the said active material.

Abstract: The present invention provides a method for treating a mammal with immunological disorders, particularly autoimmune disease, and most preferably systemic lupus erythematosus (SLE). The method includes oral administration of germination activated Ganoderma lucidum spores (“GLSs”) to the mammal. Additionally, a corticosteroid, such as prednisolone, can be co-administered with the GLSs to the mammal to achieve synergistic effect of treatment.

Abstract: The present invention relates to a compound named Percyquinnin that is obtainable by cultivating a basidiomycetes Stereum complicatum (DSM 13303), and to its pharmaceutically acceptable salts. The present invention further relates to a process for the production of Percyquinnin and to the use of Percyquinnin and its pharmaceutically acceptable salts as pharmaceuticals, in particular to their use as inhibitors of lipase.

Abstract: An oral supplement composition and method of making and using it, in which a combination of fourteen different specialized mushroom species, each of which has its own unique immunomodulatory properties, demonstrate enhancement of the immune system. When taken together, the combination of mushroom species exert a potentiated, synergistic effect that enhances immune function greater than the sum of each mushroom species' immunoenhancing influence. The oral supplement can be prepared into a variety of dosage forms, such as capsules, caplets, tablets, pills, dispersions, suspensions, solution, powders, teas, or syrup concentrates, and can be packaged in bottles or other packaging for sale.

Abstract: The present invention is a food supplement for a human body's natural immune function, formed from natural occurring substances in the form of a broth.

Abstract: The present invention advances prior art intensive repair serums by providing an intensive repair serum formulated with Morinda citrifolia from the Indian Mulberry plant. The addition of Morinda citrifolia to the serum of the present invention serves to provide significant skin care advantages not found in prior art intensive repair serums.

Abstract: An agent protective against drug-induced hepatopathy containing Lentinus edodes mycelium extract.

Abstract: There is provided a composition or a composition for oral administration which contains a mycelium fraction of a product obtained by incubation of mycelia of Ganoderma boninense as a main ingredient and induces the production of interleukin 12 (IL-12) or a supplementary food preparation for health by oral administration which is taken with an expectation of anticancer effect. There are also provided a commercial medium carrying the information concerning the above and a commercial method using the said commercial medium.

Abstract: Crude drug extracts containing soluble silicon compounds as an effective component are obtained by subjecting a crude drug to extraction with water or an aqueous solvent, preferably at an alkaline pH. The crude drugs subjected to extraction to obtain the extracts may be derived from animals, plants, etc. The quality of the crude drug extract can be standardized using the soluble silicon compounds as an index. The soluble silicon compounds exhibit inhibitory action towards the production of plasma kallikrein. The amount of soluble silicon compounds in the dry extract may be used as an index whereby the quality of various crude drugs can be standardized which contributes to providing crude drug extracts having a stable or consistent quality. Consequently, the present invention greatly contributes to the appropriate standardization of pharmaceuticals.

Abstract: Compositions are taught that may comprise active components of one or more types of Basidiomycotina that belong to polyporaceae Basidiomycotina and active components of the root of a plant that belongs to Araliaceae. Such compositions have shown hypoglycemic effects and anti-tumor activity. More preferably, the Basidiomycotina may be Ganoderma lucidum and/or Coriolus versicolor and the plant that belongs to Araliaceae may he medicinal ginseng, e.g. Panax ginseng and/or Panax japonicus. Preferably, an aqueous solution of the composition has an oxidation-reduction potential of less than about 1230 mV, more preferably less than about 900 mV and most preferably less than about 330 mV. Methods for making such compositions are also taught and may include hot water extraction of the above-mentioned components. Furthermore, methods for treating patients are also taught and include administering a therapeutically effective amount of one or more of the present compositions.

Abstract: Disclosed is a novel hyaluronidase activity and allergenic cell activity inhibitive substance useful as an effective ingredient in an anti-inflammatory or antiallergic medicament, which is an ethyl alcohol extract from body tissues or mycelia tissues of a fungus Agaricus blazei. The desired inhibitive activity of the ethyl alcohol extract is significantly higher than the corresponding hot water extract of the same fungous tissues. This difference is very prominent when the Agaricus blazei fungus cultured in a culture medium containing wheat bran and pinewood chips in combination is used as the starting material of the ethyl alcohol extraction.

Abstract: A food product suitable for reducing low density lipoprotein cholesterol levels comprising an amount of soy protein of at least 5 grams per average serving and at least 5 mg/kg statins is described. Preferably the food product comprises a fermented soy ingredient.

Abstract: Present invention relates to a method and composition for symptomatic relief of vaginitis. Until the treatment of underlying cause takes effect women suffer from unpleasant symptoms of vaginitis restricting daily routine activities. The symptoms of vaginitis may be incapacitating and are a common reason for visiting the gynecologist and can lead to frustration, embarrassment, anger, lost days from work, marital conflict and loss of ability to enjoy a normal personal, professional and social life.

Abstract: This invention provides a method for identifying a composition of Cinnamomi and Poria. This invention further provides a composition comprising: Ramulus Cinnamomi, Poria Cortex, Moutan Radicis, Radix Paeonize Alba, and Semen Persicae. This invention provides various uses of these compositions.

Abstract: A method for identifying and isolating the active fractions in fungus Cordyceps sinensis. It covers a findings of the structure of an active compound that is present in the active fractions, an isolation method that can be used to extract the active fractions and a specific active compound, and the use of F8, one specific active compound, that is present in the active fractions thus isolated, to improve the clinical symptoms of bronchial hyperresponsiveness and pulmonary injury in OA induced BNR model with enhancing Th1 cytokines suppressing Th2 and iNOS cytokines mRNA expression. This work has important pharmacological implications for the prevention and treatment of bronchial asthma in humans.

Abstract: This invention provides processes to obtain pharmaceutically active fractions from the fungus Ganoderma Lucidum. In one aspect, the process requires extracting from a homogenate of Ganoderma Lucidum a fraction isolated by column chromatography that has an optical absorbance between about 200 nm to about 280 nm. The compound and extracts are useful to inhibit the growth of endothelial cells and to inhibit vascularization in a tissue. Methods of treating various diseases, including cancer and arthritis, are also provided herein.

Abstract: The isolation, characterization, cloning and expression of the lectin (agglutinin) from Marasmius oreades (MOA) is described. MOA displays unique carbohydrate binding properties, including blood group B-specific agglutination and preferential binding to Gal&agr;1,3Gal-containing sugar epitopes, including but not limited to Gal&agr;1,3Gal&bgr;1,4GlcNAc. MOA is contemplated as an affinity reagent, a therapeutic in the treatment of antibiotic-induced diarrhea and the field of xenotransplantation. MOA may also serve as a diagnostic reagent, e.g. for malaria.

Abstract: An inventive and proprietary food supplement formula per unit to enhance the body's natural immune function against viral and infectious diseases and cancer.

Abstract: The present invention provides a composition containing an anti-acne effective amount of a combination of five components that work combinatorially to combat the acne condition as a whole. The compositions contain an anti-irritant component, an anti-inflammatory component, an adhesion inhibiting component, an sebum reducing component, and a sclareolide component. Both inflamed and non-inflamed lesions associated with the acne condition are reduced with a combination of the anti-irritant component, the anti-inflammatory component comprising at least a hoelen mushroom extract, the adhesion inhibiting component comprising at least a polysaccharide, the sebum reducing component comprising at least a pygeum extract, and the sclareolide component. The methods of the present invention treating the acne condition in a holistic manner.

Abstract: A novel substance that has the physiological activity of the aglycone of isoflavones and the physiological activity of the culture of the basidiomycetes with the physiological activities being synergistically enhanced, obtained by cultivating a basidiomycetes having a &bgr;-glucosidase activity in a medium containing an isoflavone, a method for producing it, and food, feedstuff and medicine containing it.

Abstract: A pigmented anhydrous cosmetic composition for reducing the shiny appearance of skin and cosmetically improving the appearance of skin imperfections comprising a cosmetically effective amount of mushroom extract and a method for reducing the shiny appearance of skin and cosmetically improving the appearance of skin imperfections comprising applying to the skin an anhydrous cosmetic composition containing mushroom extract.

Abstract: The present invention refers to extracts from the fungus Guignardia sp., and also a new isolate compound from the aforementioned extract, both having antimicrobial activities, particularly antibacterial and antifungal activities, and their use in pharmaceutical compositions. The new compound, isolated from the extract of the fungus Guignardia sp.

Abstract: An inventive and proprietary formula to enhance the body's natural immune function against viral and infectious diseases and cancer. The composition per unit dose in liquid or capsule gel caplets consists of: 200 to 600 mg. of Chrysin; 200 to 600 mg. of Colorius Versicolor PSK; 50 to 150 mg. of 3,3′ Diindolylmethane DIM; 50 to 150 mg. of Resveratrol 25%; 50 to 150 mg. Turmeric Extract 95%; 40 to 140 mg. Green Tea Extract 95%; 20 to 80 mg. of Quercitin Dihydrate 99%; and 15 to 75 mg. of Phosphatidyl Choline 50% Advantageously, each dose unit preferably includes 25 mg. to about 150 mgs. of Myricetin.

Abstract: A therapeutic agent for a cancer comprising a therapeutically effective amount of an active ingredient, wherein the therapeutic agent is used referring to an ability of acting on NK cell antigen receptor NKR-P1 of NKT cell as an index of the ability to activate the NKT cell.

Abstract: The present invention provides a method for preventing/slowing aging and/or reducing menopause symptoms in humans by orally administering an effective amount of germination-activated Ganoderma lucidum spores (GLSs) to humans. The treatment for menopause is especially effective in male patients. GLSs are effective as an antioxidant to reduce free radical damage, particularly by increasing the amount of the reduced form glutathione (GSH) and the superoxide dismutase (SOD) activity. GLSs can also increase testosterone level in blood and improve depression, particularly geriatric depression, in elderly male patients.

Abstract: A novel immuno-enhancing composition or functional food, novel killer activity-inducing composition or functional food, novel tumor proliferation inhibitory composition or functional food, novel interleukin 12-inducing composition or functional food, novel TGF-&bgr; activity inhibitory composition or functional food, and novel active oxygen-capturing composition or functional food, comprising as an active ingredient a hot water extract of Tricholoma matsutake or an alkaline solution extract of Tricholoma matsutake, or an adsorption fraction of a hot water extract of Tricholoma matsutake or an alkaline solution extract of Tricholoma matsutake by an anion exchange resin; and a novel adsorption fraction of a hot water extract of Tricholoma matsutake or an alkaline solution extract of Tricholoma matsutake by an anion exchange resin are disclosed.

Abstract: A multivalent fungal vaccine comprising one or more heat-inactivated fungal antigens, wherein at least one fungal antigen is effective in producing an immune response in a host when said vaccine is administered orally at a dose that is sufficient for preventing or treating the fungal disease in said host. Also described are methods for making and using an orally available anti-fungal vaccine.

Abstract: A purified shilajit composition is provided herein from native shilajit. The composition has an abundance of bioactive components, particularly, at least 0.3%, preferably 0.4-1%, by weight, oxygenated dibenzo-&agr;-pyrones and at least 60%, preferably 65-70%, by weight of fulvic acids of low-to-medium molecular weight ({overscore (M)}n of 700-2000) with an E4/E6 ratio of 8-10 at &lgr;465-665 nm, and whose 2% aqueous solution has a pH of ≧7. Personal care, pharmaceutical and nutritional use formulations of the purified shilajit composition also are described.

Abstract: Disclosed is an anti-fatigue and nutritious tonic agent containing powder of wild ginseng, optionally in admixture with a herb medicine, or water extract of the powder, which has remarkably enhanced anti-fatigue, and nutrition and tonic effects as compared with agents containing cultivated ginseng.

Abstract: A product which contains a health-promoting component and a process for preparing such a product, in the present invention, using a pulse crop as a raw material. The product accomplishes health promotion very effectively by means of at least one member of the group consisting of liver function improving constituents, cardiac function improving constituents, anti-inflammatory constituents, antifat constituents, antioxidation consititents, antimutagen constituents, and components which have an intestine-regulating effect in single-stomached animals; and the method produces such a product with good efficiency. The product of the present invention can be used directly “as is”; and alternatively, specified components may be concentrated or may be usefully utilized in applied products which use the product of the present invention as a raw material, e.g., food products, livestock feeds, pet foods or drug raw materials, etc.

Abstract: The present invention provides a composition containing an extract from Wisteria floribunda, Myristica fragrans, Punica granatum, Trapa bispinosa or a derivative thereof, Coix lachiryma-jobi, Elfvingia applanata and Ganoderma lucidum or a derivative thereof (optionally further containing Panax ginseng or Panax japonicus), which has a superior antiviral activity, a superior peripheral blood flow-improving activity and a superior hair growth-stimulating activity, and a production method thereof.

Abstract: A composition for a dietary supplement supplies components to increase the cellular formation of ATP, and thus provide energy for cellular activity. Active ingredients include 4-aminobenzoic acid, 4-hydroxybenzoic acid, L-cysteine, L-methionine, sodium molybdate, selenium, lithium bromide, horseradish powder, and shiitake mushroom powder. The composition of the present invention is administered in an oral dosage form to increase energy in humans.

Abstract: Healthy foods having both antitumor activity and activation effect for cell regeneration ability, comprising mycelia of mushrooms and one or plurality of fermented crop products, preferably, at a blending ratio of 30 to 50% by weight of mycelia and from 65 to 45% by weight of one or a plurality of fermented crop products in one embodiment, mycelia of mushrooms one or plurality of fermented crop products and calcium added thereto, preferably, at a blending ratio of 30 to 50% by weight of mycelia, from 65 to 45% by weight of fermented crop products and from 0.5 to 3% by weight of calcium in another embodiment, the fermented crop products being preferably prepared by fermenting and ripening vegetables, fruits and rood crops, and one or plurality of lytic enzymes being possibly added to the healthy foods.

Abstract: A method for treating dyslipidemia and/or post prandial hyperglycemia by administering a combination of a chromium complex and biotin to an individual in need thereof is disclosed. The two compounds are administered orally or parenterally in daily dosages which provide between 25 &mgr;g and 1,000 &mgr;g of chromium and between 25 &mgr;g and 20 mg biotin. A method for reducing the glycemic index of food is similarly provided.

Abstract: In view of an acknowledgement that keeping a healthy body is a fundamental matter for overcoming cancer, it is an object of the present invention to provide composition containing well-balanced nutrition, having an effect to suppress the mutagenesis substances, having no sub-action even if the composition is continued to be taken as nutritious supplemental substance and capable of promoting healthy state. There are provided a nutritious supplemental composition for suppression against large intestinal cancer and its manufacturing method in which dietary fiber in a range of 15 wt % to 30 wt % in respect to a total amount of composition is contained in the dried koji fine powder including dead fungi of Aspergillus while keeping a capability of catalysis of groups of enzyme produced by Aspergillus.

Abstract: A composition for a dietary supplement supplies components to increase the cellular formation of ATP, and thus provide energy for cellular activity. Active ingredients include 4-aminobenzoic acid, 4-hydroxybenzoic acid, L-cysteine, L-methionine, sodium molybdate, selenium, lithium bromide, horseradish powder, and shiitake mushroom powder. The composition of the present invention is administered in an oral dosage form to increase energy in humans.

Abstract: The invention relates to cosmetic compositions for topical application for counteracting UV radiation induced skin damage comprising as active substances a first component which comprises inactivated bacteria selected from the group consisting of the genus Bifidobacterium, Actinomycetaceae, Propionimycetaceae, Lactobacillaceae and Coryneform bacteria and a second component which comprises an extract of plant extracellular matrix. Preferably, the plant extracellular matrix is selected from the group consisting of glycoproteins, carbohydrate polymers and arabinogalactan proteins. Processes for using the cosmetic compositions are also described.

Abstract: The present invention describes new and distinct strains of higher Basidiomycetes mushrooms grown in submerged cultures. Specifically, the new strain of species of the genus Tremella offer superior yields of one-cell biomass and exocellular heteropolysaccharide glucuronoxylomannan, niacin and essential amino acids.

Abstract: An orally ingested composition for prevention, stabilization, reversal and treatment of cancer. Most notably, a nutrient compositions for the treatment of cancer containing omega 3 fatty acids, polysaccharide dietary fibers and coenzyme Q10.

Abstract: A white fungus of genus Sphingomonas, when washed with acetone and then extracted with alcohol or alcohol-water mixture yields a shingoglycolipid represented by the following formula: 1

Abstract: The invention concerns the field of pharmaceutics and dietetics. More particularly, the invention concerns novel pharmaceutical and/or dietetic mushroom-based compositions, characterised in that they contain one or several edible mushrooms with therapeutic properties and chitosan.

Abstract: The present invention describes a method for germination activating spores of Ganoderma lucidum to produce bioactive substances which has medicinal effects on patients with immunological disorders, cancer, AIDS, hepatitis, diabetes, and cardiovascular diseases, and can prevent or inhibit free radical oxidation and hepatotoxic effects. The method can be subdivided into three stages. At the first stage, a germination activation method is introduced which includes soaking the spores in a solution to induce germination, and placing the germination treated spores in a culture box to induce the synthesis of bioactive substances and softening of the cell walls of the spores. At the second stage, sporoderm-broken ganoderma spores are collected by treating the epispores with cell wall breaking enzymes and/or mechanical force. At the last stage, the bioactive substances are extracted from the sporoderm-broken spores by drying at low temperature followed by extraction.