Extract Or Material Containing Or Obtained From A Multicellular Fungus As Active Ingredient (e.g., Mushroom, Filamentous Fungus, Fungal Spore, Hyphae, Mycelium, Etc.) Patents (Class 424/195.15)
  • Patent number: 6464981
    Abstract: A therapeutic agent for a cancer comprising a therapeutically effective amount of an active ingredient, wherein the therapeutic agent is used referring to an ability of acting on NK cell antigen receptor NKR-P1 of NKT cell as an index of the ability to activate the NKT cell.
    Type: Grant
    Filed: December 26, 2000
    Date of Patent: October 15, 2002
    Assignee: Orient Cancer Therapy Co., LTD
    Inventor: Akikuni Yagita
  • Patent number: 6464982
    Abstract: The invention concerns an immune system stimulator comprising Ganoderma Lucidum, Dioscoreae Oppositae, Chrysanthemum Morifolium, Radix Astragali, and Folium Isatidis. The composition is capable of mediating enhanced production of Interleukin-1 beta without causing an increase in the production of Interleukin-4.
    Type: Grant
    Filed: November 2, 2001
    Date of Patent: October 15, 2002
    Assignee: Chinese Herbal USA, Inc.
    Inventor: Paul Y. S. Lam
  • Publication number: 20020146394
    Abstract: The present invention utilizes the pre-sporulation (preconidial) mycelial stage of entomopathogenic fungi as insect attractants and/or pathogens. The fungus can be cultivated on grain, wood, agricultural wastes or other cellulosic material, attracting the insect and optionally introducing insect-specific pathogenic fungi. More than one fungus and substrate can be used in combination. The matrix of preconidial fungi can optionally be dried, freeze-dried, cooled and/or pelletized and packaged and reactivated for use as an effective insect attractant and/or biopesticide. Attractant extracts of the preconidial entomopathogenic mycelium are disclosed.
    Type: Application
    Filed: October 1, 2001
    Publication date: October 10, 2002
    Inventor: Paul Edward Stamets
  • Publication number: 20020141960
    Abstract: A shaving composition containing a skin-tightening effective amount of an astringent additive, wherein the shaving composition is applied onto human skin prior to shaving.
    Type: Application
    Filed: November 7, 2001
    Publication date: October 3, 2002
    Inventors: James A. McCaulley, Pat Hoontrakul
  • Patent number: 6458361
    Abstract: A producing method of Tien Hsien Liquid which mainly comprises ginseng, cordyceps, and ganoderma lucidum, including the steps of: soaking and heating the ginseng, cordyceps, ganoderma lucidum in water with honey and sorbic acid dissolved therein to form an extract solution; mixing and stirring the extracted solution with supplemental solution to form a combined solution; adding a predetermined amount of powder pearl into the combined solution; and filtering out the combined solution to obtain the Tien Hsien Liquid.
    Type: Grant
    Filed: July 17, 2001
    Date of Patent: October 1, 2002
    Inventor: Michael S. Ng
  • Publication number: 20020131978
    Abstract: The present invention relates to a method for extracting the oleaginous substances from sporoderm-broken Ganoderma spores using SCF-CO2. The method requires: (1) breaking the Ganoderma spores by a mechanical means to obtain the sporoderm-broken spores; and (2) extracting the oleaginous substances from the sporoderm-broken spores using a supercritical fluid-carbon dioxide (SCF-CO2) extraction method. The preferred supercritical conditions include 5 M to 60 M Pa of pressure; 32° C. to 85° C. of temperature; and 5 kg/h to 80 kg/h of flow capacity rate. The total extraction time in SCF-CO2 is between 0.5 hour and 6 hours. The method produces approximately 37% by weight of oleaginous substances from the sporoderm-broken Ganoderma spores. These oleaginous substances are transparent and contain the special fragrance of Ganoderma spores. There is no trace of deposit, solvent residue, or oxidization in the oleaginous substances.
    Type: Application
    Filed: March 19, 2001
    Publication date: September 19, 2002
    Inventors: Xin Liu, Xiao-Ni Huang, Peter Chee-Keung Chung
  • Publication number: 20020131977
    Abstract: The present invention relates to a method for extracting the oleaginous substances from sporoderm-broken Ganoderma spores using SCF—CO2. The method contains the steps of: (1) inducing germination of Ganoderma spores by incubating the spores in a nutritional solution; (2) activating the Ganoderma spores by placing the germination-induced spores in a well ventilated culture box kept at constant temperature and humidity; (3) breaking the Ganoderma spores by a mechanical means to obtain the sporoderm-broken spores; and (4) extracting the oleaginous substances from the sporoderm-broken spores using a supercritical fluid—carbon dioxide (SCF—CO2) extraction method. The preferred supercritical conditions include 5 M to 60 M Pa of pressure; 32° C. to 85° C. of temperature; and 5 kg/h to 80 kg/h of flow capacity rate. The total extraction time in SCF—CO2 is between 0.5 hour to 6 hour.
    Type: Application
    Filed: March 19, 2001
    Publication date: September 19, 2002
    Inventors: Xin Liu, Xiao-Ni Huang, Peter Chee-Keung Chung
  • Publication number: 20020127243
    Abstract: A dietary supplement comprising as its active ingredients soybean, mushroom and mung bean is used in a method to in a method to ameliorate at least one effective malignancy or viral infection or to enhance immune functions. The active components of the dietary supplement include phytoestrogens, &bgr;-glucans, saponins, inositol hexaphosphate, and lectins.
    Type: Application
    Filed: January 10, 2002
    Publication date: September 12, 2002
    Inventor: Alexander S. Sun
  • Publication number: 20020119136
    Abstract: Enzymatic compositions comprising a Coprinus peroxidase, hydrogen, peroxide or a source of hydrogen peroxide, and an enhancing agent such as an electron donor, e.g., phenothiazine-10-propionic acid; 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonate); acetosyringate; C1-8-alkylsyringate; or a water-soluble halide or thiocynate salt such as potassium iodide, have antimicrobial properties useful e.g., for inhibiting or killing microorganizms present in laundry, on human or animal skin, hair, mucous membranes, oral cavities, teeth, wounds, bruises, and on hard surfaces, and can be used as disinfectant, a preservative for cosmetics, and for cleaning, disinfecting or inhibiting microbial growth on process equipment used for e.g. water treatment, food processing, chemical or pharmaceutical processing, paper pulp processing, and water sanitation.
    Type: Application
    Filed: March 23, 2001
    Publication date: August 29, 2002
    Applicant: Novozymes A/S
    Inventor: Charlotte Johansen
  • Publication number: 20020119164
    Abstract: Agaricus blazei in whole, particulate, or extracted form, are useful as a barrier when applied to the skin against harmful effects of environmental toxins, pollution, chemicals, and radiation. Taken internally, whole, particulate, or extracted Agaricus blazei offer protection from various disorders such as autoimmune disorders, and alone or in conjunction with other therapies, can be beneficial to treat such disorders.
    Type: Application
    Filed: August 20, 2001
    Publication date: August 29, 2002
    Inventors: Shoji Uchiyama, Kenji Haramaki
  • Patent number: 6440420
    Abstract: The present invention relates to a method for extracting the oleaginous substances from sporoderm-broken Ganoderma spores using SCF—CO2. The method contains the steps of: (1) inducing germination of Ganoderma spores by incubating the spores in a nutritional solution; (2) activating the Ganoderma spores by placing the germination-induced spores in a well ventilated culture box kept at constant temperature and humidity; (3) breaking the Ganoderma spores by a mechanical means to obtain the sporoderm-broken spores; and (4) extracting the oleaginous substances from the sporoderm-broken spores using a supercritical fluid—carbon dioxide (SCF—CO2) extraction method. The preferred supercritical conditions include 5 M to 60 M Pa of pressure; 32° C. to 85° C. of temperature; and 5 kg/h to 80 kg/h of flow capacity rate. The total extraction time in SCF—CO2 is between 0.5 hour to 6 hour.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: August 27, 2002
    Inventors: Xin Liu, Xiao-Ni Huang, Peter Chee-Keung Chung
  • Publication number: 20020110564
    Abstract: Nutriceutical compositions prepared from the basidiomycete Agaricus blazei Murill, grown in China and more particularly from the Fujian province of China, are provided. The invention also provides methods for using such compositions to prevent and treat cancer, and to lower blood sugar levels.
    Type: Application
    Filed: December 8, 2000
    Publication date: August 15, 2002
    Inventor: Mark Itokawa
  • Publication number: 20020090380
    Abstract: Novel formulation useful in the treatment of drug resistant bacterial infections comprising an effective amount of ‘Thymol’ obtained from the plant Trychyspermum ammi, combination of mint oil containing appropriate amounts of monoterpene obtained from Mentha spicata and Mentha arvensis and obtaining conventional additives, a method for producing the formulation by mixing the above ingredients and a method for the treatment of drug resistant in a patient by administration of a therapeutically effective amount of the said formulation.
    Type: Application
    Filed: March 28, 2000
    Publication date: July 11, 2002
    Inventors: Suman Preet Singh Khanuja, Suchi Srivastava, Ajit Kumar Shasney, Mahendra Pandurang Darokar, Tiruppadiripuliyur Ranganathan Santha Kumar, Krishna Kumar Agarwal, Ateeque Ahmed, Nirmal Kumar Patra, Prachi Sinha, Sunita Dhawan, Dharmendra Saikia, Sushil Kumar
  • Publication number: 20020081314
    Abstract: It is an object of the present invention to provide composition having an action of suppression against onset of diabetes capable of suppressing an onset of diabetes normally known as one to be hardly healed, in particular, severe type I autoimmune diabetes. There is provided an undevitalized enzyme fortified composition in which starch and protein contained in mixed raw material of mixture of embryo bud and seed coat of rice and fruit body of ganoderma lucidum are decomposed into low molecules by aspergills oryzae strain colony, and are changed into dried fine powder with a moisture content of 4% or less under a state in which enzyme groups generated by aspergills oryzae strain colony are contained as they are and the enzyme groups do not loose capability of catalysis, vitamin B groups are added to and mixed with the dried fine powder and each of the enzyme groups holds the capability of catalysis of the enzyme proper.
    Type: Application
    Filed: October 18, 2001
    Publication date: June 27, 2002
    Inventor: Teruaki Iwasaki
  • Patent number: 6403083
    Abstract: A pharmaceutical composition comprising activated hemicellulose (AHCC), a method for inducing IL-12 in a living body having tumor cells by administering the composition, and a method for treating cancer by administering the composition are provided.
    Type: Grant
    Filed: November 23, 1999
    Date of Patent: June 11, 2002
    Inventor: Akikuni Yagita
  • Publication number: 20020068097
    Abstract: Compositions, including pharmaceutical formulations, of plants and plant material, and specifically, extracts thereof are disclosed for use in the treatment of Irritable Bowel Syndrome, and for use in the treatment related bowel disorders, are disclosed. The compositions of the invention are useful in that they alleviate one or more of the symptoms of Irritable Bowel Syndrome, and of related bowel disorders. A particularly preferred pharmaceutical formulation is disclosed that consists essentially of aqueous extracts of one or more of “Bai Shao” (Paeonia lactiflora), “Bai Zhu” (Atractylodes macrocephala), “Chen Pi” (Citrus reticulata), “Fang Feng” (Saposhnikovia divaricata), together with one or more of “Wu Mei” (Prunus mume), and “Yan Hu” (Corydalis yanhusuo).
    Type: Application
    Filed: May 18, 2001
    Publication date: June 6, 2002
    Inventor: Amaresh Basu
  • Patent number: 6399060
    Abstract: A pesticide composition that includes a metabolite from a fungus selected from homeocarpic basidiomycetes and homeocarpic ascomycetes is described. In one embodiment, the fungus from which the metabolite is derived is one grown under conditions effective to substantially suppress fruiting of the fungus. More particular the pesticide compositions are provided comprising a fungal metabolite derived from a fungus selected from the group Ganoderma spp., Lactiporus spp., Lentinus spp., Morchella spp., and Pleurotus spp. The pesticide composition may be produced by culturing the fungus on a medium containing vegetable oil and a surfactant. Alternatively a filtrate from a culture of the fungus is added to the medium containing vegetable oil and a surfactant, and mixed until pesticidal activity develops.
    Type: Grant
    Filed: October 25, 2000
    Date of Patent: June 4, 2002
    Assignee: ABR, LLC
    Inventor: Bryan Hiromoto
  • Publication number: 20020064522
    Abstract: A pharmaceutical composition comprising activated hemicellulose (AHCC), a method for inducing IL-12 in a living body having tumor cells by administering the composition, and a method for treating cancer by administering the composition are provided.
    Type: Application
    Filed: December 3, 2001
    Publication date: May 30, 2002
    Inventor: Akikuni Yagita
  • Patent number: 6395280
    Abstract: An oral deodorant for excreta containing a proanthocyanidin as an active ingredient and a method of reducing the odor of excreta of an object comprising dosing the object with an effective amount of a proanthocyanidin.
    Type: Grant
    Filed: July 27, 2000
    Date of Patent: May 28, 2002
    Assignee: Kikkoman Corporation
    Inventors: Jun Yamakoshi, Shigehiro Kataoka, Hiroshi Hosoyama, Toshiaki Ariga
  • Patent number: 6387375
    Abstract: Species of fungi have been identified, which can be used to control coleopteran infestations of host plants. The fungi are particularly useful for controlling infestations of Diaprepes abbreviatus.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: May 14, 2002
    Assignees: Morse Enterprises Limited, Inc., United States of America
    Inventors: Hamed Doostdar, Richard T. Mayer
  • Publication number: 20020048589
    Abstract: The present invention refers to extracts from the fungus Guignardia sp., and also a new isolate compound from the aforementioned extract, both having antimicrobial activities, particularly antibacterial and antifungal activities, and their use in pharmaceutical compositions. The new compound, isolated from the extract of the fungus Guignardia sp.
    Type: Application
    Filed: August 1, 2001
    Publication date: April 25, 2002
    Inventors: Katia Ferreira Rodrigues Heerklotz, Jorg Arno Heerklotz, Christa Werner
  • Publication number: 20020044947
    Abstract: The invention concerns an immune system stimulator comprising Hericium, Radix Astragali, Cordyceps Sinensus, Radix Glycyrrhizae and Dioscoreae Oppositae. The composition is capable of mediating enhanced production of Interleukin-1 beta without causing an increase in the production of Interleukin-4.
    Type: Application
    Filed: June 21, 2001
    Publication date: April 18, 2002
    Inventor: Paul Y.S. Lam
  • Patent number: 6372462
    Abstract: The present invention describes new and distinct strains of higher Basidiomycetes mushrooms, and a process for growing them in submerged culture. Specifically, the new strains of species of the genus Pleurotus offer superior yields of mushroom biomass and concentrations of biologically active compounds, for example, cholesterol-lowering compounds, lectins, proteins, essential amino acids, vitamins or polysaccharides. The process includes use of defined media and a simple one-step procedure of separating the lovastatin-containing nutriceuticals from culture broth.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: April 16, 2002
    Assignee: MedMyco Ltd.
    Inventors: Solomon P. Wasser, Sergey V. Reshetnikov
  • Publication number: 20020039587
    Abstract: Compositions and methods for treating hand or wrist discomfort are provided. The compositions comprise singly or in combination herbals, natural nutritional supplements, minerals and vitamins. Methods of making these compositions are also provided.
    Type: Application
    Filed: June 1, 2001
    Publication date: April 4, 2002
    Inventor: Yuanjin Tao
  • Patent number: 6355251
    Abstract: Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds to chemexfoliate selected epidermal cell populations are disclosed.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: March 12, 2002
    Inventor: Mark Zamoyski
  • Patent number: 6346250
    Abstract: The invention provides compositions and methods that are useful for treating colic in mammals (e.g. human infants).
    Type: Grant
    Filed: January 11, 2001
    Date of Patent: February 12, 2002
    Assignee: LEV Laboratories Ltd.
    Inventor: Sergei Shushunov
  • Patent number: 6346251
    Abstract: Sesquiterpene epoxide compounds (trichothecenes) and methods for administering such compounds to inhibit proliferation of psoriatic cell populations in the epidermis are disclosed.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: February 12, 2002
    Inventor: Mark Zamoyski
  • Publication number: 20020012659
    Abstract: A product which contains a health-promoting component and a process for preparing such a product, in the present invention, using a pulse crop as a raw material. The product accomplishes health promotion very effectively by means of at least one member of the group consisting of liver function improving constituents, cardiac function improving constituents, anti-inflammatory constituents, antifat constituents, antioxidation consititents, antimutagen constituents, and components which have an intestine-regulating effect in single-stomached animals; and the method produces such a product with good efficiency. The product of the present invention can be used directly “as is”; and alternatively, specified components may be concentrated or may be usefully utilized in applied products which use the product of the present invention as a raw material, e.g., food products, livestock feeds, pet foods or drug raw materials, etc.
    Type: Application
    Filed: July 10, 2001
    Publication date: January 31, 2002
    Applicant: NICHIMO CO., LTD.
    Inventors: Minoru Takebe, Jitsuo Shiraishi
  • Publication number: 20020010149
    Abstract: A therapeutic agent for a cancer comprising a therapeutically effective amount of an active ingredient, wherein the therapeutic agent is used referring to an ability of acting on NK cell antigen receptor NKR-P1 of NKT cell as an index of the ability to activate the NKT cell.
    Type: Application
    Filed: December 26, 2000
    Publication date: January 24, 2002
    Inventor: Akikuni Yagita
  • Publication number: 20020001594
    Abstract: An object of the present invention is to provide pharmacological compound including a component having pressure reductive activity obtained from Mycoleptodonoides aitchisonii fruit body which is safe and cheap, harvested constantly year-round by artificial cultivation, with equal quality, and useful for prevention and/or amelioration of symptom of hypertension caused by angiotensin I converting enzyme or the like, also to provide food or beverage such as functional drinks including the pharmacological compound and having pressure reductive activity as well as excellent palatability.
    Type: Application
    Filed: March 30, 2001
    Publication date: January 3, 2002
    Inventors: Taku Sato, Nobuhito Shiragaki, Tomoe Kawatsu, Toshihiko Hori
  • Patent number: 6316002
    Abstract: The present invention describes a method for germination activating spores of red Ganoderma lucidum to produce bioactive substances which has medicinal effects on patients with immunological disorders, cancer, AIDS, hepatitis, diabetes, and cardiovascular diseases, and can prevent or inhibit free radical oxidation and hepatotoxic effects. The method can be subdivided into three stages. At the first stage, a germination activation method is introduced which includes soaking the spores in a solution to induce germination, and placing the germination treated spores in a culture box to induce the synthesis of bioactive substances and softening of the cell walls of the spores. At the second stage, sporoderm-broken ganoderma spores are collected by treating the epispores with cell wall breaking enzymes and/or mechanical force. At the last stage, the bioactive substances are extracted from the sporoderm-broken spores by drying at low temperature followed by extraction.
    Type: Grant
    Filed: March 13, 2000
    Date of Patent: November 13, 2001
    Inventors: Xin Liu, Chee-Keung Chung
  • Publication number: 20010031265
    Abstract: The present invention describes a method for germination activating spores of red Ganoderma lucidum to produce bioactive substances which has medicinal effects on patients with immunological disorders, cancer, AIDS, hepatitis, diabetes, and cardiovascular diseases, and can prevent or inhibit free radical oxidation and hepatotoxic effects. The method can be subdivided into three stages. At the first stage, a germination activation method is introduced which includes soaking the spores in a solution to induce germination, and placing the germination treated spores in a culture box to induce the synthesis of bioactive substances and softening of the cell walls of the spores. At the second stage, sporoderm-broken ganoderma spores are collected by treating the epispores with cell wall breaking enzymes and/or mechanical force. At the last stage, the bioactive substances are extracted from the sporoderm-broken spores by drying at low temperature followed by extraction.
    Type: Application
    Filed: March 12, 2001
    Publication date: October 18, 2001
    Inventors: Xin Liu, Chee-Keung Chung
  • Publication number: 20010016197
    Abstract: The present invention describes new and distinct strains of higher Basidiomycetes mushrooms, and a process for growing them in submerged culture. Specifically, the new strains of species of the genus Pleurotus offer superior yields of mushroom biomass and concentrations of biologically active compounds, for example, cholesterol-lowering compounds, lectins, proteins, essential amino acids, vitamins or polysaccharides. The process includes use of defined media and a simple one-step procedure of separating the lovastatin-containing nutriceuticals from culture broth.
    Type: Application
    Filed: October 15, 1999
    Publication date: August 23, 2001
    Inventors: SOLOMON P. WASSER, SERGEY V. RESHETNIKOV
  • Publication number: 20010000229
    Abstract: The present invention relates to an active oxygen scavenging agent and a cancer chemopreventing agent both comprising a dried Grifola, a dry Grifola powder and/or a Grifola extract, and to a food or animal feed comprising the active oxygen scavenging agent or the cancer chemopreventing agent.
    Type: Application
    Filed: December 6, 2000
    Publication date: April 12, 2001
    Inventors: Kenji Tazawa, Yasuo Odaira, Masataka Watanabe