Abstract: A novel method of treating and preventing viral diseases is provided. In particular, the present invention relates to compositions and methods for inhibition of viral infections and the diseases associated with such viral infections. More particularly, the present invention relates to the inhibitory compounds comprising naturally occurring and man-made compositions comprising a substance exhibiting Tubercin and/or SSM activity or a functional derivative thereof.

Abstract: This invention provides a method for treating Parkinson's disease (PD), particularly early stage of PD by orally administering to a mammal sporoderm-broken germination activated Ganoderma lucidum spore powders (GASP) to reduce and/or release the symptom of rotatory behavior in PD, to reduce the progression of neuron apoptosis and to improve the tyrosine hydroxylase (TH) activity so as to increase the conversion of hydroxydopamine (DOPA) to dopamine in the dopaminergic neurons. This invention also provides a method for reducing neuron apoptosis and a method for improving TH activity in dopaminergic neurons by orally administering to a mammal GASP.

Abstract: Methods are described for producing reduced, methylated, biologically active forms of folate, including 5-methyltetrahydrofolate (i.e. 5-methyltetrahydropteroylglutamic acid), 5-formyltetrahydrofolate, 10-formyltetrahydrofolate and tetrahydrofolate. Edible mushroom-producing fungi are cultivated to enhance the uptake of pteroylmonoglutamate (synthetic folate) into edible portions of the plants. The mushroom-producing fungi reduce and methylate the pteroylmonoglutamates into activated folates. The cultivated mycelia or mushrooms of the mushroom-producing fungi are harvested, and may be consumed directly or processed into oral dosage formats (capsules, tablets, softgels, powders, gel packets, liquids, nutritional bars, beverages) for use as functional foods or nutritional supplements.

Abstract: A Phytoceutical composition for the prevention and treatment of Multiple Sclerosis (MS) and symptoms is provided. A specific combination of extracts of plants and nutraceuticals is taught, as well as principles for varying the formulations based on categorizing plants into one of three groups, Energy, Bio-Intelligence, and Organization and selecting several plants from each group. Such combinations have synergistic effects, with minimal side effects.

Abstract: The present invention provides a method for extracting lipids from microorganisms without using organic solvent as an extraction solvent. In particular, the present invention provides a method for extracting lipids from microorganisms by lysing cells and removing water soluble compound and/or materials by washing the lysed cell mixtures with aqueous washing solutions until a substantially non-emulsified lipid is obtained.

Abstract: Phytoceutical composition for the prevention and treatment of HIV/AIDS and/or immune disorders. A specific combination of extracts of plants is taught, as well as the formulations based on categorizing plants into one of three groups, Energy, Bio-Intelligence and Organization. Such combination has synergistic effects, with minimal side effects.

Abstract: The present invention provides a method for preventing or ameliorating neural damage in a mammalian fetus or a newborn infant, which is caused by maternal gestational hypertension (GH). The method includes orally administering germination activated sporoderm-broken Ganoderma lucidum spores (“GLSs”) to a pregnant mammal having GH. The neural damage includes a decrease in hippocampal cell proliferation and neuron number. The present invention further provides a method for preventing or ameliorating the increased expression of hippocampal hypoxia inducible factor (HIF-1a) and vascular endothelial growth factor (VEGF) in a mammalian embryo caused by maternal GH.

Abstract: The present invention provides a method for treating or preventing intestinal bacterial imbalance (IBI) in a mammal. The method includes orally administering a composition comprising germination activated sporoderm-broken Ganoderma lucidum spore powder (“GLSs”) or a mixture of GLSs and beneficial intestinal bacteria, such as Lactobacillus bifidus, to a mammal suffering from IBI or having a tendency to develop IBI.

Abstract: Described herein are compositions derived from natural products useful in reducing or preventing pain in a subject and methods of use thereof.

Abstract: A Kampo medicinal extract-containing tablet composition contains a Kampo medicinal extract powder, cellulose glycolate and sodium hydrogen carbonate. It preferably further contains silicic anhydride. A process to manufacture a Kampo medicinal extract-containing tablet composition by the step of adding silicic anhydride and water to a Kampo medicinal extract powder, stirring and granulating the mixture, and the step of mixing the granulated substance with cellulose glycolate and sodium hydrogen carbonate. The Kampo medicinal extract-containing tablet composition can be satisfactorily disintegrated and dissolved and a process for manufacturing the same, by formulating specific compounds to a Kampo medicinal extract powder.

Abstract: The invention provides a powdered formulation which is a freeze-dried mixture of a sensitive active material and an excipient containing: 0.1-50% by wt of the sensitive active material, 50-99.99% by wt of the excipient, wherein at least 0.1% by wt of the mixture is an amorphous state; the formulation has a substantially reduced hygroscopicity.

Abstract: The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of components of Ganoderma lucidum. These active extracts and fractions are useful for inhibiting tumor growth, modulating immune response, and increasing hematopoietic activity.

Abstract: Compositions and methods for treating osteoporosis, the formation of osteoeclasts, and/or for the suppression of decreasing spongy bone density. Example methods include administering Cordyceps sinensis or its processed product.

Abstract: New compositions including salt components and/or antioxidant-containing botanical extract components, such as bamboo leaf extracts, acai berry extracts, lotus leaf extracts, other antioxidant-containing botanical extracts and mixtures thereof, are provided. The present compositions effectively take advantage of the chemical make-ups and/or properties of these components to provide new and/or enhanced benefits relative to substantially identical compositions without such components.

Abstract: The present invention relates to a new pharmaceutical composition from natural materials belonging in traditional Chinese medicine and to its preparation method. Said new pharmaceutical composition comprises Astragalus root, Pleurotus fungi, Winnged Euonymus Twig and Mulberry Leaf. At first, astragalus root, Pleurotus fungi, Winnged Euonymus Twig and Mulberry Leaf are extracted by water or alcohol to obtain extractive. The obtained extractive can be got by extracting the above four materials together, or by combining the extractive from the three materials together (stragalus root, Winnged Euonymus Twig and Mulberry Leaf) among above four materials with the extractive from Pleulotus fungi singly. Then the mixed extractive is centrifugalized and separated. If need be, the gained centrifugate can be made into oral formulations in various dose form with excipient by routine method. Said pharmaceutical composition has the effect of regulating immunity on the body.

Abstract: A dietary supplement comprising as its active ingredients soybean, mushroom and mung bean is used in a method to in a method to ameliorate at least one effective malignancy or viral infection or to enhance immune functions. The active components of the dietary supplement include phytoestrogens, ?-glucans, saponins, inositol hexaphosphate, and lectins.

Abstract: The present invention provides a cell-free protein synthesis method characterized by a cell-free protein synthesis reaction solution that is weakly reducing and suitable for protein folding, performing a weakly reducing synthesis reaction, and preferably performing a translation reaction with the further addition of a substance catalyzing a disulfide bond exchange reaction at the beginning of the translation reaction. This method allows for proper formation of intramolecular disulfide bonds in the protein and efficiently provides protein having substantially the same function as the original protein. Specifically, it provides antibody protein that binds specifically to an antigen.

Abstract: A substantially microbe-free composition containing plant growth regulators is produced by culturing a fungal spawn on high carbohydrate medium under suitable conditions. The culture filtrate is sterilized, formulated, and used to enhance plant growth.

Abstract: The present invention relates to a pyroligneous liquor sheet containing a pyroligneous powder, and more particularly to a pyroligneous liquor sheet having an excellent effect of removing waste matters by means of a contact surface with a human body. The pyroligneous liquor sheet according to the present invention provides a pyroligneous liquor sheet which is a pocket-type sack composed of an air-permeable sheet coming in contact with the skin and an air-impermeable sheet facing the air-permeable sheet and having a permeable network in at least one surface thereof, wherein a chamber, surrounded by the air-permeable sheet and the air-impermeable sheet, is filled with a pyroligneous powder mixture, wherein the pyroligneous powder mixture includes 0.

Abstract: The invention relates to a method for treatment of chronic myelogenous leukemia (CML), Ph+ acute lymphoblastic leukemia (ALL), prostate cancer and ?-globin disorders such as sickle cell anemia and ?-thalassemia, comprising administration of a mycelium extract from at least one higher Basidiomycetes medicinal mushroom selected from the group consisting of Ganoderma adspersum, Hypsizygus ulmarium, Kuehneromyces mutabilis, Omphalotus olearius, Panus conchatus, Piptoporus betulinus, Pleurotus eryngii, and Trametes zonata.

Abstract: The present invention relates to an extract of Elfvingia applanata, which shows a therapeutic activity for diabetes and diabetic complications and a pharmaceutical composition for the treatment of diabetes and diabetic complications comprising the extract.

Abstract: Flavones with an isoprenyl group in the 8-position possess very good anti-inflammatory properties and can also be used to treat/prevent/cure skin-disorders when applied in food compositions.

Abstract: A process for preparing dry extracts from a liquid extract and at least one additional substance by a spray-drying process, characterized in that said at least one additional substance is added to the spray-drying process in a dry form during the spray-drying processes.

Abstract: The present invention relates to the establishment of a cultivation condition that is suitable for the large-scale production of pharmacologically active filtrates from a culture of A. camphorata, in particular, by optimizing the agitation rate and/or pH value during the cultivation. The present invention also relates to a process for obtaining pharmacologically active compositions from a culture of A. camphorata through a series of fractionation. This invention is further directed to the uses of the above compositions in the preparation of pharmaceutical compositions.

Abstract: Present invention relates to a method and composition for symptomatic relief of vaginitis. Until the treatment of underlying cause takes effect women suffer from unpleasant symptoms of vaginitis restricting daily routine activities. The symptoms of vaginitis may be incapacitating and are a common reason for visiting the gynecologist and can lead to frustration, embarrassment, anger, lost days from work, marital conflict and loss of ability to enjoy a normal personal, professional and social life.

Abstract: The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of plant components of Ganoderma lucidum. These active extracts and fractions are useful for inhibiting tumor growth, modulating immune response, and increasing hematopoietic activity.

Abstract: It is intended to provide means of efficiently, economically and conveniently dyeing fibers or hair, bleaching pulp or fibers, removing phenol compounds from liquid wastes, degrading endocrine disruptors, producing phenolic resins, producing artificial lacquer coatings, improving wood qualities, etc. A culture of a strain belonging to the genus Flammulina; a culture originating in the above strain which is obtained by culturing the strain at a pH value exceeding 7 and has a phenol oxidase-like activity; a process for producing the culture; a dyeing method which comprises contacting a subject to be dyed with a dye in the presence of the above culture; and a dyeing composition containing the above culture.

Abstract: The present invention provides a method for treating patients with spinal cord injury by administering germination activated Ganoderma lucidium spores (GASP) to the patients. The GASP are sporoderm-broken. The GASP promote axon regeneration and improve motor neuron survival in the injured spinal cord.

Abstract: The present invention utilizes the pre-sporulation (preconidial) mycelial stage of entomopathogenic fungi as insect attractants and/or pathogens. The fungus can be cultivated on grain, wood, agricultural wastes or other cellulosic material, attracting the insect and optionally introducing insect-specific pathogenic fungi. More than one fungus and substrate can be used in combination. The matrix of preconidial fungi can optionally be dried, freeze-dried, cooled and/or pelletized and packaged and reactivated for use as an effective insect attractant and/or biopesticide. Attractant extracts of the preconidial entomopathogenic mycelium are disclosed.

Abstract: The present invention provides a method for fetal protection by orally administering germination activated Ganoderma lucidum spore powder (“GASP”) to pregnant mammals. GASP demonstrates prophylactic effects on fetal damage in pregnant mammals, particularly humans.

Abstract: The present invention provides an external preparation for skin which contains, as a major ingredient, oleaginous substances extracted from sporoderm-broken spores from Ganoderma lucidum. The spores are preferably being treated with germination activation. The oleaginous substances are preferred to be extracted by a supercritical fluid-carbon dioxide (SCF-CO2) method. The oleaginous substances prepared by SCF-CO2 is transparent and odorless. They also demonstrates effects on skin smoothening, wrinkles reduction, aging defiance, inflammation lessening, pigmentation lightening, and irritation alleviation. The external preparation can be a cosmetic or a therapeutic composition.

Abstract: This invention provides a method for identifying a composition of Cinnamomi and Poria. This invention further provides a composition comprising: Ramulus Cinnamomi, Poria Cortex, Moutan Radicis, Radix Paeonize Alba, and Semen Persicae. This invention provides various uses of these compositions.

Abstract: This invention provides compositions and methods for stimulating the immune system. Such methods include administering an extract, purified peptide-linked glucan or active component thereof from Coriolus versicolor. The methods are particularly useful for prophylactic and therapeutic treatment of secondary immunodeficiency, wherein the immunodeficiency is the result of an infection, a malignant neoplastic disease, an autoimmune disease, a protein losing state, an immunosuppressive treatment, surgery or anesthesia.

Abstract: In view of the finding that keeping a healthy body is fundamental for overcoming cancer, it is an object of the present invention to provide a nutritious composition that is effective in suppressing mutagenic substances and promoting good health. The composition also suppresses large intestinal cancer. The composition includes dietary fiber in a range of 15 wt % to 30 wt % in respect to the total amount of composition which is contained in dried koji fine powder that includes dead fungi of Aspergillus and active enzyme produced by the Aspergillus.

Abstract: The present invention relates to the establishment of a cultivation condition that is suitable for the large-scale production of pharmacologically active filtrates from a culture of A. camphorata, in particular, by optimizing the agitation rate and/or pH value during the cultivation. The present invention also relates to a process for obtaining pharmacologically active compositions from a culture of A. camphorata through a series of fractionation. This invention is further directed to the uses of the above compositions in the preparation of pharmaceutical compositions.

Abstract: A highly deacetylated chitosan obtained from microbial biomass, a method of obtaining chitosan from microbial biomass, and biomass for making chitosan are disclosed. The method includes providing chitin-containing biomass; reacting the chitin-containing biomass in a caustic solution of greater than 25 percent alkali at a reaction temperature greater than 95° C. for a reaction period of at least 10 hours to convert the chitin in the biomass to chitosan; and separating the chitosan from the caustic solution.

Abstract: The present invention provides a composition containing an extract from Wisteria floribunda, Myristica fragrans, Punica granatum, Trapa bispinosa or a derivative thereof, Coix lachiryma-jobi, Elfvingia applanata and Ganoderma lucidum or a derivative thereof (optionally further containing Panax ginseng or Panax japonicus), which has a superior antiviral activity, a superior peripheral blood flow-improving activity and a superior hair growth-stimulating activity, and a production method thereof.

Abstract: The invention is directed to an aqueous hair care composition comprising a) at least one UV-absorbing substance, and b) at least one mica/titanium dioxide pigment wherein at least 90% by weight of the mica/titanium dioxide pigment comprises a particle size between about 10 and 250 microns, c) green tea extract, and wherein the entire composition has a pH no greater than about 6.

Abstract: It is an object of the present invention to provide immunopotentiators and immunotherapeutic formulations available at low cost and having a benign side effect profile. According to the present invention, an LAK activity enhancer containing an extract of Lentinus edodes mycelium and an LAK activity-enhancing formulation containing said enhancer are provided.

Abstract: The present invention provides a method for preventing/slowing aging and/or reducing menopause symptoms in humans by orally administering an effective amount of germination-activated Ganoderma lucidum spores (GLSs) to humans. The treatment for menopause is especially effective in male patients. GLSs are effective as an antioxidant to reduce free radical damage, particularly by increasing the amount of the reduced form glutathione (GSH) and the superoxide dismutase (SOD) activity. GLSs can also increase testosterone level in blood and improve depression, particularly geriatric depression, in elderly male patients.

Abstract: The present invention provides a method for treating a mammal with immunological disorders, particularly autoimmune disease, and most preferably systemic lupus erythematosus (SLE). The method includes oral administration of germination activated Ganoderma lucidum spores (“GLSs”) to the mammal. Additionally, a corticosteroid, such as prednisolone, can be co-administered with the GLSs to the mammal to achieve synergistic effect of treatment.

Abstract: A composition for reducing blood sugar in humans in need thereof, contains Agaricus blazeii, alpha lipoic acid, transfer factor, polymannose, fenugreek, coenzyme Q-10, selenium, zinc, vitamin C, vitamin E, chromium and vanadium.

Abstract: The invention relates to a cosmetic preparation containing an active complex comprised of extracts. The active complex contains at least one starting substance, which is extracted as an aqueous extract from real truffles (Tuberaceae) and which is provided in a cosmetically acceptable gel while being stabilized. A preferred active complex is one that additionally contains a champagne product. Cosmetic preparations containing this active complex lead to an improved stimulation of the immune system, an improved regenerative effect and thus to an improved balance in the ecosystem of the skin.

Abstract: In view of the finding that keeping a healthy body is fundamental for overcoming cancer, it is an object of the present invention to provide a nutritious composition that is effective in suppressing mutagenic substances and promoting good health. The composition also suppresses large intestinal cancer. The composition includes dietary fiber in a range of 15 wt % to 30 wt % in respect to the total amount of composition which is contained in dried koji fine powder that includes dead fungi of Aspergillus and active enzyme produced by the Aspergillus.

Abstract: Methods are described for producing reduced, methylated, biologically active forms of folate, including 5-methyltetrahydrofolate (i.e. 5-methyltetrahydropteroylglutamic acid), 5-formyltetrahydrofolate, 10-formyltetrahydrofolate and tetrahydrofolate. Edible mushroom-producing fungi are cultivated to enhance the uptake of pteroylmonoglutamate (synthetic folate) into edible portions of the plants. The mushroom-producing fungi reduce and methylate the pteroylmonoglutamates into activated folates. The cultivated mycelia or mushrooms of the mushroom-producing fungi are harvested, and may be consumed directly or processed into oral dosage formats (capsules, tablets, softgels, powders, gel packets, liquids, nutritional bars, beverages) for use as functional foods or nutritional supplements.

Abstract: The present invention provides a nutrient absorption enhancing composition that contains a mixture of various Aspergillus derived enzymes and mineral cofactors. In one aspect, the enzymes of the formulation may include protease, lipase, amylase, and cellulase. In another aspect, the mineral cofactors of the formulation may include calcium compounds, zinc compounds, manganese compounds, and magnesium compounds.

Abstract: This invention provides a preparation method of fermentation product of Cryptoporus volvatus (Peck) Schear and its clinical use, the said Cryptoporus volvatus (Peck) Schear is cultured on culture medium for fluid fermentation or solid fermentation to obtain mycelium of Cryptoporus volvatus (Peck) Schear, culture supernatant fluid and various metabolins, the culture medium of which contains glucose, maltose, yeast powder, peptone, inorganic salts and vitamins. The said fermentation product can be made into kinds of drug forms to prevent and treat irritability diseases, for example, bronchus asthma, allergic rhinitis, allergic gastroenteritis or ophthalmopathy which is caused by pollen, acarid, mildew or dust. Moreover, it can be used for preventing and treating cough.

Abstract: Described are a deodorizer agent for a mouth cavity with excellent odor eliminating ability, and a composition, a food composition and a deodorizing composition which contain the deodorizer agent.

Abstract: A composition for reducing blood sugar in humans in need thereof, contains Agaricus blazeii, alpha lipoic acid, transfer factor, polymannose, fenugreek, coenzyme Q-10, selenium, zinc, vitamin C, vitamin E, chromium and vanadium.

Abstract: The invention concerns a formulation containing phosphatidylserine (PS) and/or lyso-phosphatidylserine for preventing and treating mental and physical stress states, where the phosphatidylserine is, among others, combined with plant extracts or essences. Daily doses of 50 to 1000 mg PS are envisaged within the scope of the present invention which are administered over a maximum period of six months. Preferred subjects are humans of 10 to 50 years of age.