Effervescent Or Pressurized Fluid Containing Patents (Class 424/43)
  • Patent number: 10650228
    Abstract: A device for detecting and recording animal behavior is provided. The device includes at least one corral that defines a contained field, the base surface of the at least one corral being sensitive to the animal's footprint. The device also includes an image capturing device that cooperates with the base surface to capture a first video frame in which at least one of a tail, body and head of the animal is illuminated by a light below the animal and a second video frame in which both a profile of a full footprint and a profile of a toe print of the animal when the animal is standing on its toes is illuminated by a light that is totally internally reflected within the base surface. A control system is arranged to control the image capturing device to capture the first and second video frames.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: May 12, 2020
    Assignees: Children's Medical Center Corporation, President and Fellows of Harvard College
    Inventors: David P. Roberson, Clifford J. Woolf, Michael T. Do, Alexander B. Wiltschko, Sandeep Robert Datta
  • Patent number: 10617688
    Abstract: The present invention pertains to the technological sector of the pharmaceutical industry and, more specifically, refers to a second use composition intended for the treatment of a dermatology condition called Poikiloderma of Civatte. The solution proposed in this document is the use of a topical composition containing any substance alone or in combination from the pharmacological group of alpha-adrenergic receptor agonists in therapeutic quantities to treat color of the lesions of Poikiloderma of Civatte. The application of this composition for the condition of Poikiloderma of Civatte results in significant improvement of the color of the skin lesions, also improving the vascular component present in this condition and can be associated with other compounds.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: April 14, 2020
    Inventor: Doris Maria Hexsel
  • Patent number: 10617419
    Abstract: A surgical buttress includes a body portion and a band disposed on each of the distal and proximal ends thereof. The surgical buttress is configured to attach to an end effector of a surgical stapling apparatus. The body portion, having perforations disposed thereon, overlies the working surface of one of the first or second jaws of the end effector. A resilient portion extends transversely beyond the side edges of the first or second jaws. Each band remains attached to the end effector following the firing thereof. The proximal band is removably attachable to a hook feature disposed on one of the first or second jaws of the end effector. The surgical buttress can be made from suitable degradable or non-degradable materials. One embodiment contemplates a detachable and disposable single use loading unit. A method of attaching the surgical buttress to a surgical apparatus is also envisioned.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: April 14, 2020
    Assignee: Covidien LP
    Inventor: Lee Olson
  • Patent number: 10532124
    Abstract: Farnesol analogs, along with their related products (e.g., treatment compositions, wipes, absorbent articles, etc.) and their methods of formation, are provided. The farnesol analog includes a hydrophilic end group (e.g., a hydroxyl end group or a carboxylic acid end group) attached to farnesol via a covalent linkage (e.g., an ester group or an ether group).
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: January 14, 2020
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: David William Koenig, Mary Kay Foegen, Corey Thomas Cunningham, Aimin He, Yang Huang
  • Patent number: 10471077
    Abstract: The present invention provides a medical aerosol suspension formulation of MDI administration, comprising: a) micronized pa-agonist; b) micronized corticosteroid; c) a sib-therapextric quantity of a moisture-scavenger excipient; and d) a HFA propellant; wherein (a), (b), and (c) and their respective relative amounts are selected such that they associate to form floccules having a density substantially the same as that of the HFA propellant.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: November 12, 2019
    Assignee: Jagotec AG
    Inventors: Rudi Mueller-Walz, Lise-Marie Fueg
  • Patent number: 10474791
    Abstract: A method for identifying a dairy animal, the method comprising the steps of: providing an identification system comprising an imaging device and a database of stored vein patterns; obtaining at least one image of at least a portion of an udder of the dairy animal; extracting a vein pattern from the at least one image; comparing the extracted vein pattern to the database of stored vein patterns; and identifying, based on said comparison, the dairy animal in the database of stored vein patterns.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: November 12, 2019
    Assignee: ACUMEN DETECTION, INC.
    Inventors: Timothy Francis Moshier, Kenton Arthur Doctor, Stephanie A. C. Schuckers, Sean K. Banerjee, Boyang Li
  • Patent number: 10471063
    Abstract: The invention provides a composition which comprises (a) a PDE3/PDE4 inhibitor which is 9,10-Dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one or a pharmaceutically acceptable acid addition salt thereof and (b) a muscarinic receptor antagonist.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: November 12, 2019
    Assignee: Verona Pharma PLC
    Inventors: Michael J. A. Walker, Mario Cazzola, Luigino Calzetta
  • Patent number: 10420765
    Abstract: A concentrated inhalable formulation of an antibiotic drug such as ciprofloxacin is disclosed. The antibiotic is formulated with sodium acetate and liposome which incorporate antibiotic. The formulation is aerosolized and inhaled for treatment of respiratory tract infections and other medical conditions.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: September 24, 2019
    Assignee: ARADIGM CORPORATION
    Inventors: David C. Cipolla, James Blanchard
  • Patent number: 10406200
    Abstract: The present invention provides compositions and formulations comprising glutathione with or without thiocyanate and methods of use thereof to treat diseases and disorders in mucosal/epithelial tissue.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: September 10, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Roland R. Arnold, David C. Henke
  • Patent number: 10350164
    Abstract: A process for preparing a dry powder formulation for inhalation comprising a combination of an anti-cholinergic, a long-acting beta2-adrenoceptor agonist, and, optionally, an inhaled corticosteroid, is provided.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: July 16, 2019
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Alessandro Cavecchi, Cristiana Merusi, Fausto Pivetti, Francesca Schiaretti
  • Patent number: 10265268
    Abstract: The present invention addresses the issue of providing an external composition for screen foamers such as pump foamers, that can be safely used even when not removed after application. Provided is an external composition for screen foamers, including a non-ionic surfactant as a foaming component and, ideally, being in a soluble state.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: April 23, 2019
    Assignee: POLA PHARMA INC.
    Inventors: Hirokazu Kobayashi, Takaaki Masuda, Tetsuya Endo, Kahori Fujii
  • Patent number: 10251460
    Abstract: An apparatus and method for providing cosmetic treatment to skin comprise one material chemically active in a solid form preferably in a tablet form and a second material which is chemically reactive with the first material so that effervescence is produced during the reaction. The chemically active materials may be activated by a user for providing cosmetic treatment to skin. The activation releases effervescence which urges granules of the reacting materials onto the skin. The size of the granules lowers during the reaction thus providing continuously refining peeling to the skin.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: April 9, 2019
    Assignee: POLLOGEN LTD.
    Inventor: Pinchas Shalev
  • Patent number: 10233209
    Abstract: Disclosed are inhibitors of the farnesoid X receptor, for example of formula (I), wherein R1, R2, R4, X, Y, Z, m, and n are as defined herein, which are useful in treating or preventing obesity, type 2 diabetes/insulin resistance and non-alcoholic fatty liver disease in a mammal in need thereof. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the invention, a method of method of inhibiting a farnesoid X receptor in a mammal, and a method of treating or preventing obesity in a mammal.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: March 19, 2019
    Assignees: The United States of America, As represented by the Secretary, Department of Health and Human Services, The Penn State Research Foundation
    Inventors: Frank J. Gonzalez, Changtao Jiang, Cen Xie, Andrew D. Patterson, Fei Li, James B. Mitchell, Shantu Amin, Dhimant Desai
  • Patent number: 10226444
    Abstract: Composition for topical application, for use in increasing the trophism of nasal mucosa, comprising an ester of vitamin E with a carboxylic acid of formula R—COOH, in which R is an alkyl radical having 1 to 19 carbon atoms, or an alkenyl or alkynyl radical having 2 to 19 carbon atoms, and an oily vehicle; such composition can be used for the treatment of chronic atrophic rhinitis and for obtaining tissue repair of the nasal mucosa following nasal and sinus surgery.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: March 12, 2019
    Assignee: BIO.LO.GA. S.R.L.
    Inventors: Giorgio Panin, Domenico Testa, Germano Guerra
  • Patent number: 10179122
    Abstract: The present invention relates to melatonin or a pharmaceutically acceptable salt thereof for use as a medicament, the use of melatonin or a pharmaceutically acceptable salt thereof for the preparation of medicament, the use of melatonin as a food supplement and a pharmaceutical unit dosage form.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: January 15, 2019
    Inventor: Darius Rassoulian
  • Patent number: 10166180
    Abstract: Described are methods for treating a keratinized tissue condition in a subject in need thereof. The method may include providing the subject including the keratinized tissue condition. The method may include conducting one or more treatment cycles on the keratinized tissue. Each treatment cycle may include contacting the keratinized tissue with an acid-activated gas-generating composition. Each treatment cycle may include contacting the keratinized tissue with an acid composition. Each treatment cycle may include allowing the acid composition and the acid-activated gas-generating composition to react effective to generate a gas at the keratinized tissue. The one or more treatment cycles may be effective to at least partly ameliorate the keratinized tissue condition in the subject.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: January 1, 2019
    Inventor: Marty Richard Hunter
  • Patent number: 10143626
    Abstract: The present invention generally relates to a pharmaceutical dosage form and controlled release of biologically active agents, diagnostic agents, reagents, cosmetic agents, and agricultural/insecticide agents. In one embodiment, the dosage form has a substrate that forms a compartment, wherein the substrate includes at least a first piece and a second piece, wherein the first piece operably links to the second piece. The dosage form contains a drug content that is loaded into the compartment. The dosage form also has a releaser operably linked to the substrate which upon contact with water or body fluid is capable of separating the first and second piece to open the compartment and release the drug content.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: December 4, 2018
    Assignee: TRIASTEK, INC.
    Inventor: Xiaoling Li
  • Patent number: 10099246
    Abstract: Disclosed herein is an improved marking material, consisting essentially of food quality colorant (such as food coloring), and a carrier (such as water, or vegetable oil or canola oil). A method for using this material for the marking of environmental locations is also disclosed. In one form the material also comprises a propellant, all contained within a pressurized aerosol canister. The aerosol canister embodiment having a valve assembly connected to an actuator and aperture for selectively releasing the marking material. In another form, a pump-style spray bottle is utilized, and in another form a larger fluid container, pump and spray-wand type dispersal unit such as the devices commonly used in lawn and garden care, or equivalent apparatus may be utilized. In these forms, the material may consist of water-based food coloring and/or oil-based food coloring and vegetable oil depending on whether the application is dry surface or snow.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: October 16, 2018
    Inventor: Benjamin Lear Belcher
  • Patent number: 10034943
    Abstract: A pharmaceutical or cosmetic carrier for topical administration substantially consists of phosphatidylcholine, monoglyceride, fatty acid ester of C1-C3 alcohol; volatile solvent selected from ethanol and its combinations with C3-C4 alcohol and/or volatile silicone oil. Also disclosed are pharmaceutical and cosmetic compositions comprising the carrier and pharmaceutically or cosmetically active agent(s).
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: July 31, 2018
    Assignee: LIPIDOR AB
    Inventors: Bengt Herslöf, Jan Holmbäck
  • Patent number: 10015963
    Abstract: Optically isotropic, thermodynamically and chemically stable microemulsions of antimicrobials comprising of mixtures of N-undecylenoyl glycine, N-capryloyl glycine and 2-phenoxy ethanol for preservation of personal care products are described herein. They offer a broad spectrum of antimicrobial activity by inhibiting the growth of bacteria as well as fungi that can otherwise flourish in personal care products rendering them unsuitable for the use. The personal care products that can be preserved by these microemulsions of antimicrobials are, gels, serums, solutions, lotions, creams, emulsions, wet wipes and the like, containing water in varying amount.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: July 10, 2018
    Assignee: GNA Surfactants Ltd.
    Inventors: Nirmal Koshti, Bhagyesh Jagannath Sawant, Santosh Vishnu Kadam, Srinivas Uppalaswamy Pilli, Devyani Ashok Mali, Shraddha Kiran Ratnaparkhe, Pooja Vaidya Kshirsagar
  • Patent number: 10016507
    Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: July 10, 2018
    Assignee: Frequency Therapeutics, Inc.
    Inventors: Christopher Loose, Will McLean, Megan Harrison, Michael R. Jirousek
  • Patent number: 9999677
    Abstract: A wound healing composition and method for wound healing utilizing a nitrofurazone in a water soluble ointment, activated charcoal, caustic and biebrich scarlet. Applying the composition to the wound and observing epithelial healing along the sides and bottom of the wound. Stopping treatment when the epithelial tissue fills the wound.
    Type: Grant
    Filed: March 7, 2015
    Date of Patent: June 19, 2018
    Inventor: Connie D. Starns
  • Patent number: 9980981
    Abstract: The invention provides compositions and methods for delivering carbon monoxide (CO) to subjects suffering from inflammatory, cardiovascular, Sickle Cell, and other disease. The compositions are liquids, including Newtonian and non-Newtonian liquids, such as pastes, gels, foams, emulsions, and other non-gaseous compositions, in which CO is dissolved at an amount that, when administered to a patient, provides a therapeutically or prophylactically effective amount of CO to the patient. The compositions can be provided in many forms, including in bottles or cans.
    Type: Grant
    Filed: January 10, 2012
    Date of Patent: May 29, 2018
    Assignee: CHILDREN'S HOSPITAL LOS ANGELES
    Inventors: Edward D. Gomperts, Henry J. Forman
  • Patent number: 9974736
    Abstract: The invention relates to an oily composition of a non-steroidal anti-inflammatory agent (NSAIA) for parenteral administration with at least one micronized NSAIA, having an acid function and a biocompatible oily vehicle, such that said NSAIA is in the form of a free acid and said composition does not contain any added liquid agent that can solubilize said NSAIA. The invention also relates to the veterinary use thereof.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: May 22, 2018
    Assignee: VIRBAC
    Inventor: Nathalie Delhom
  • Patent number: 9949548
    Abstract: An apparatus and method for providing cosmetic treatment to skin comprise one material chemically active in a solid form preferably in a tablet form and a second material which is chemically reactive with the first material so that effervescence is produced during the reaction. The chemically active materials may be activated by a user for providing cosmetic treatment to skin. The activation releases effervescence which urges granules of the reacting materials onto the skin. The size of the granules lowers during the reaction thus providing continuously refining peeling to the skin.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: April 24, 2018
    Assignee: POLLOGEN LTD.
    Inventor: Pinchas Shalev
  • Patent number: 9849083
    Abstract: The invention provides a pharmaceutical composition for the transmucosal delivery of a statin, said composition comprising a statin and a carrier in which said statin is soluble or forms a suspension or emulsion. The invention also provides a pharmaceutical composition comprising a statin for use in inhibiting cholesterol synthesis in vivo, where in said use said composition is delivered by the transmucosal route.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: December 26, 2017
    Assignee: LondonPharma Ltd.
    Inventors: Martin James Sams, Juliet Victoria High, Paul Andrew Jamieson, Clive Booles
  • Patent number: 9802012
    Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, with or without a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, hormones such as insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, diseases and disorders, including endocrine disease such as diabetes and/or obesity.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: October 31, 2017
    Assignee: MannKind Corporation
    Inventors: Chad C. Smutney, Benoit Adamo, Brendan F. Laurenzi, P. Spencer Kinsey
  • Patent number: 9801832
    Abstract: The present patent application relates to a pharmaceutical composition, characterized in that it comprises at least one active ingredient which can bring about a singlet oxygen-independent direct catalase inactivation and that the composition further comprises at least one active ingredient that leads to inactivation of catalase as a result of modulation of the nitrogen oxide or superoxide anion metabolism of the cells and subsequent singlet oxygen formation.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: October 31, 2017
    Assignee: Universitaetsklinikum Freiburg
    Inventor: Georg Bauer
  • Patent number: 9789106
    Abstract: The present invention relates a foamable otic pharmaceutical compositions comprising oil-in water emulsions which comprise an antibiotic agent and a propellant gas. The pharmaceutical compositions are administered to the ear as foam for treating ear disorders.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: October 17, 2017
    Assignee: OTIC PHARMA LTD.
    Inventors: Evgenia Lozinsky, Yanna Galibov, Rodrigo Yelin
  • Patent number: 9750280
    Abstract: Disclosed is a pH-stabilized oral tobacco composition comprising a buffer of at least two pH stabilizing substances comprising potassium carbonate and at least one additional pH stabilizing substance that can maintain a low total drop in pH-value over prolonged time at ambient as well as refrigerated temperature, so that the freshness and shelf life of the oral tobacco composition can be improved.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: September 5, 2017
    Assignee: JT International S.A.
    Inventor: Rory Parsons
  • Patent number: 9737472
    Abstract: The present disclosure relates to methods and compositions comprising naturally occurring light absorbing molecules for preventing damages from light exposure. Specific embodiments of this disclosure include fluorescent proteins from Brachiostoma lanceolatum.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: August 22, 2017
    Assignee: ALLELE BIOTECHNOLOGY & PHARMACEUTICALS, INC.
    Inventor: Jiwu Wang
  • Patent number: 9718686
    Abstract: The present invention provides a safe, disposable and biodegradable chlorine dioxide micro generator that uses water soluble paper and hydrogel or compressed cellulose encased in filter paper pouch. The chemicals are kept in a stabilize form until activated by the addition of water. Multiple levels of protection against early exposure to water such as a foil pouch and an impermeable outer container allow for the safe transportation and storage in small, ready for deployment amounts of the chemicals. Water permeated the chemical pack housing and dissolves the paper walls of the chemical pouch housing and then the water facilitates the reaction between the acid and the sodium chlorite to form chlorine dioxide gas as will be described further hereunder. Absorbent and permeable materials packaged around the chemicals provide for the safe containment of the chlorine dioxide solution, and the expeditious aeration and release of the chlorine dioxide gas, once the chemical reaction has been completed.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: August 1, 2017
    Inventors: Juan Carlos Baselli, Spencer Blua
  • Patent number: 9693983
    Abstract: Use of glyceryl trinitrate (GTN) for treating traumatic edemas.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: July 4, 2017
    Assignee: G. Pohl-Boskamp GmbH & Co. KG
    Inventor: Marianne Boskamp
  • Patent number: 9650203
    Abstract: The replacement of chlorofluorohydrocarbon propellants in medical aerosols is of the utmost importance to the pharmaceutical industry. A number of formulations have been investigated. The present invention provides a medical aerosol formulation comprising a particular medicament, a fluorocarbon propellant and 6 to 25% w/w of the total formulation of a polar co-solvent, such formulation being substantially free of surfactant. Canisters suitable for delivering such a pharmaceutical formulation are also provided.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: May 16, 2017
    Assignee: NORTON HEALTHCARE LIMITED
    Inventor: Fiona Catherine Millar
  • Patent number: 9629362
    Abstract: A method for killing insects, involving treating an object or area with an insect killing effective amount of a composition containing methyl benzoate and optionally a carrier.
    Type: Grant
    Filed: January 5, 2016
    Date of Patent: April 25, 2017
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE
    Inventors: Aijun Zhang, Yan Feng
  • Patent number: 9603807
    Abstract: The invention provides a method of ameliorating inflammation in a patient involving administering to the patient a therapeutically effective dose of composition including polystyrene divinyl benzene copolymer and a polyvinyl pyrrolidone polymer. More particularly, the method relates to using these polymers as an enteral sorbent preparation to remove inflammatory mediators, such as cytokines, from the intestinal lumen. The polymers can be in the form of a preparation of polystyrene divinyl benzene copolymer beads with a biocompatible polyvinyl pyrrolidone polymer coating.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: March 28, 2017
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: John A. Kellum, Mitchell P. Fink
  • Patent number: 9549898
    Abstract: A waterless foamable pharmaceutical composition suitable for external administration is disclosed. The composition includes a foamable carrier least one liquefied or compressed gas propellant. The foamable carrier includes at least one liquid oil; at least one silicone and at least one least one stabilizing agent; wherein the stabilizing agent selected from the group consisting of about 0.01% to about 25% by weight of at least one surface-active agent alone or on combination with a foam adjuvant; and about 0% to about 5% by weight of at least one polymeric agent alone or on combination with a foam adjuvant; and mixtures thereof. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: January 24, 2017
    Assignee: Foamix Pharmaceuticals Ltd.
    Inventors: Dov Tamarkin, Helena Shifrin, Rita Keynan, Enbal Ziv, Tal Berman, David Schuz, Elana Gazal
  • Patent number: 9532986
    Abstract: Methods of treatment of NTM lung infections using formulations of liposomal ciprofloxacin. Specific liposome formulations and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: January 3, 2017
    Assignees: ARADIGM CORPORATION, OREGON STATE UNIVERSITY
    Inventors: Igor Gonda, James Blanchard, David C. Cipolla, Luiz Eduardo Moreira Bermudez
  • Patent number: 9526790
    Abstract: The present invention relates to pharmaceutical compositions and in particular to suspension aerosol pharmaceutical compositions, processes to obtain them and their use in inhalation therapy.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: December 27, 2016
    Assignee: Generics [UK] Limited
    Inventors: Paul Flanders, James Thompson
  • Patent number: 9511198
    Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: December 6, 2016
    Assignee: MannKind Corporation
    Inventors: Chad C. Smutney, P. Spencer Kinsey, Carl R. Sahi, Benoit Adamo, John M. Polidoro, Scott McLean, Dennis Overfield, Anthony Bryant, Tom He, Alfred Mann
  • Patent number: 9447123
    Abstract: The process for preparing 2-hydroxyphenyl alkenyl benzotriazole compounds and the process for preparing siloxane compounds containing 2-hydroxyphenyl benzotriazole function are disclosed.
    Type: Grant
    Filed: October 25, 2010
    Date of Patent: September 20, 2016
    Assignee: L'OREAL
    Inventors: Herve Richard, Jinzhu Xu, Patricio Guerreiro, Yuan Wang, Jianping Guo
  • Patent number: 9387251
    Abstract: This invention relates to a composition and its use for formulating nucleic acid-based drugs/vaccines with sugar alcohol compositions into complexes for both in-vitro and in-vivo delivery. Particularly, the present invention includes the ingredients and processes necessary for formulating therapeutic and pharmaceutical nucleic acid compositions, such as miRNA, microRNA precursors, shRNAs, siRNAs, ribozymes, antisense RNAs/DNAs, RNA-DNA hybrids and DNA vectors/vaccines, with glycylated sugar alcohols/sugars into delivery complexes, which can then be absorbed by cells in vivo and in vitro via active endocytosis. Also, the present invention discloses that chemical compounds containing sugar alcohol- and/or sugar-like structures can protect nucleic acids, in particular miRNAs, shRNAs, siRNAs and ribozymes, from degradation in vivo as well as in vitro.
    Type: Grant
    Filed: August 12, 2014
    Date of Patent: July 12, 2016
    Inventors: Shi-Lung Lin, David T S Wu
  • Patent number: 9314427
    Abstract: The invention provides compositions and methods for the improvement of distance vision. The invention further provides compositions and methods for the treatment of refractive errors of the eye. The invention further provides compositions that preferably comprise aceclidine lyophilized with a cryoprecipitate separate or together with a diluent comprising a cycloplegic agent, a surfactant, and optionally a viscosity enhancer.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: April 19, 2016
    Assignee: Presbyopia Therapies LLC
    Inventors: Gerald Horn, Lee Nordan
  • Patent number: 9242124
    Abstract: Low-temperature stable concentrate compositions comprising an acyl glycinate present in an amount greater than 70 wt % by weight of the composition; and b) at least one of a zwitterionic surfactant or an amphoteric surfactant present in an amount greater than 0.1 wt % by weight of the composition, wherein the concentrate is low temperature stable.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: January 26, 2016
    Assignee: Rhodia Operations
    Inventors: James Griffin, Stewart Warburton, David Dobrowolski
  • Patent number: 9206204
    Abstract: A process for preparing a siloxane compound comprising a 2-hydroxyphenyl benzotriazole function which comprises at least one step in which a reaction for hydrosilylation of a compound 2-hydroxyphenyl benzotriazole comprising a substituent having a terminal double bond with a siloxane compound comprising an SiH function is carried out in the presence of a catalyst and of at least one volatile organic solvent corresponding to one of formula (VII) or (VIII). in which R4 and R5, which may be identical or different, represent a linear or branched C1-C4 alkyl radical, with the proviso that the sum of the carbons of R4 and R5 is less than or equal to 6; y is and integer between 1 and 3; R6 which may be identical or different, are linear or branched C1-C3 alkyl radicals, with the proviso that the sum of the carbons of R6 is less than or equal to 6 is disclosed.
    Type: Grant
    Filed: October 25, 2010
    Date of Patent: December 8, 2015
    Assignee: L'OREAL
    Inventors: Herve Richard, Patricio Guerreiro, Jianping Guo, Wensheng Tang
  • Patent number: 9198840
    Abstract: A pumpable liquid spray formulation for retarding degradation of color cosmetics, the pumpable liquid spray formulation being characterized by: the presence of at least one encapsulated evaporative cooling agent; and at least one entrained solvent; and the absence of fluorocarbon-based evaporative cooling agents, whereby the reduction of the surface temperature of the color cosmetics is achieved by a controlled release of the entrained solvents by the at least one encapsulated evaporative cooling agent.
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: December 1, 2015
    Assignee: Skindinavia, Inc.
    Inventor: Allen S. Goldman
  • Patent number: 9186342
    Abstract: The invention relates to an oral pharmaceutical composition comprising the combination of an ibuprofen salt or S(+)-ibuprofen with L-arginine and/or the pharmaceutically acceptable salts thereof, and additionally pharmaceutically acceptable vehicles and/or excipients. The invention also relates to the method of producing the composition and to the use of said composition having synergic therapeutic activity, for treating moderate to severe inflammatory pain, fever and inflammation.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: November 17, 2015
    Assignee: LABORATORIOS SENOSIAIN S.A. DE C.V.
    Inventors: Juan Pablo Senosiain Peláez, Angélica Arzola Paniagua, Enrique Raúl García-Salgado López
  • Patent number: 9149482
    Abstract: A chewable tablet comprising Cefixime having a mean particle size between 20? and 120? wherein the said composition demonstrates bioequivalence to a suspension of Cefixime trihydrate. The process of preparation of the chewable tablet comprises the steps of optionally micronizing Cefixime such that the mean particle size of the Cefixime particles is between 20? and 120?, blending with other excipients, roll compaction, milling to form granules, blending to form a secondary blend and compression of the secondary blend to form tablets.
    Type: Grant
    Filed: May 10, 2004
    Date of Patent: October 6, 2015
    Assignee: Lupin Ltd.
    Inventors: Sanjay Wagh, Hidaytulla Aga, Makarand Avachat, Himadri Sen
  • Patent number: 9132116
    Abstract: Provided herein are mast cell stabilizers used to prevent, treat, or mitigate severity of laminitis. Mast cell stabilizers can be combined with antihistamines and other medicaments to prevent, treat, or mitigate severity of laminitis.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: September 15, 2015
    Assignee: WILLOWCROFT PHARM INC.
    Inventor: Charles F. Owen
  • Publication number: 20150140046
    Abstract: Compounds of general formula (I): R1-Wn-Xm-AA1-AA2-AA3-AA4-AA5-AA6-AA7-AA8-AA9-Yp-Zq-R2 (I) their stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, preparation processes, cosmetic or pharmaceutical compositions which contain them and their use in medicine, particularly in the treatment and/or prevention of pain, inflammation, itching, neurological, compulsive and/or neuropsychiatric diseases and/or disorders and in processes of treatment and/or care of the skin, hair and/or mucous membranes mediated by neuronal exocytosis.
    Type: Application
    Filed: April 12, 2013
    Publication date: May 21, 2015
    Inventors: Antonio Vicente Ferrer Montiel, Gregorio Fernández Ballester, José María García Antón, Cristina Carreño Serraïma, Núria Almiñana Doménech, Raquel Delgado González