Organic Pressurized Fluid Patents (Class 424/45)
  • Patent number: 10987288
    Abstract: A deep-sea water concentrate skin application kit of deep-sea active concentrate and skincare formula is provided. The deep-sea water concentrate skin application kit has the following properties of micronizing the skincare formulas immediately, and decreasing the surface tension of the deep-sea active concentrate immediately; furthermore, the deep-sea active concentrate can become a driving force for the permeability of the micronized skincare formulas. Therefore, the deep-sea water concentrate skin application kit can be more easily absorbed into the skin (dermis). A manufacturing method of the deep-sea water concentrate skin application kit is also provided to improve skin appearance.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: April 27, 2021
    Inventors: Yin-Ming Lo, Jane-Yi Su
  • Patent number: 10980920
    Abstract: Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: April 20, 2021
    Assignee: Arsenal Medical, Inc.
    Inventors: Upma Sharma, Irina Gitlin, Gregory T. Zugates, Adam Rago, Parisa Zamiri, Rany Busold, Robert J. Caulkins, Toby Freyman, Quynh Pham, Changcheng You, Jeffrey Carbeck
  • Patent number: 10973763
    Abstract: Inhalable pharmaceutical compositions can include an aqueous dispersion of particles including a hydrophobic bioactive agent (e.g., CoQ10) suitable for continuous aerosolization. Due to their chemical composition and methods of manufacture, the pharmaceutical compositions exhibit distinctive physicochemical properties that provide advantageous aerosol transmission and output.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: April 13, 2021
    Assignee: Berg LLC
    Inventors: Niven Rajin Narain, John Patrick McCook
  • Patent number: 10966925
    Abstract: The present invention is directed to epinephrine spray formulations. The present invention is further directed to methods of treating anaphylaxis by administering epinephrine spray formulations to subjects in need of such treatments.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: April 6, 2021
    Assignee: HIKMA PHARMACEUTICALS USA INC.
    Inventors: Thrimoorthy Potta, Craig Bastian, Ningxin Yan, Venkat Goskonda, Chandeshwari Chilampalli, Rachana Inavolu, Eshwaran Narayanan
  • Patent number: 10945950
    Abstract: The present invention relates to a liquid pharmaceutical composition suitable for administration by inhalation which comprises a diluent and a suspension of particles of 9,10-dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one (RPL554) or a pharmaceutically acceptable salt thereof. Also described is a liquid pharmaceutical composition according to the invention for use in the treatment of the human or animal body.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: March 16, 2021
    Assignee: VERONA PHARMA PLC
    Inventors: Peter Lionel Spargo, Edward James French, Phillip A. Haywood
  • Patent number: 10933018
    Abstract: Provided herein are novel isotretinoin formulations that provide an enhanced targeted dermal delivery system for the drug isotretinoin with improved thermodynamic activity using no to a small level of ethanol relative to existing isotretinoin gel products, and methods for treatment of ichthyosis and other skin conditions using the same.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: March 2, 2021
    Assignee: Timber Pharmaceuticals LLC
    Inventors: Zachary Rome, Charles Rodney Greenaway Evans, Marc Barry Brown, Francesco Caserta
  • Patent number: 10933019
    Abstract: The present invention relates to liquid pharmaceutical compositions comprising daptomycin, methods of providing such compositions and the use thereof. Provided herein are formulations comprising daptomycin, one or more polar protic solvents, and mixtures thereof. Formulations according to the present invention can further comprise polar aprotic solvent and/or source of calcium.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: March 2, 2021
    Assignee: XELLIA PHARMACEUTICALS APS
    Inventors: Tina Gjoni, Dubravka Strazic
  • Patent number: 10925924
    Abstract: Disclosed is a dry-powder peptide medicament with a non-typical concentration of carbohydrate excipient, as well as said medicament for use in treatment or prevention of a disease or condition, as well as methods for manufacturing said medicament.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: February 23, 2021
    Assignee: APEPTICO FORSCHUNG UND ENTWICKLUNG GMBH
    Inventor: Bernhard Fischer
  • Patent number: 10925689
    Abstract: The present invention relates to nitric oxide (NO)-releasing nail coating compositions, NO-releasing coatings, and methods of using the same, for example, to treat fungal infections of a nail. It is noted that aspects described with respect to one embodiment may be incorporated in different embodiments although not specifically described relative thereto. Provided according to embodiments of the invention are nitric oxide (NO)-releasing nail coating compositions and/or coatings.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: February 23, 2021
    Assignee: Novan, Inc.
    Inventors: Ryan Doxey, Yong Zhang
  • Patent number: 10905697
    Abstract: The application provides formulations for the topical administration of an active agent comprising at least one steroid, in the form of topical sprays that are propellant-free, and/or substantially non-foaming, and/or alcohol-free. The present application also provides processes for preparing such compositions and methods of using them in management of skin diseases or disorders such as psoriasis, dermatoses, and other associated skin diseases or disorders.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: February 2, 2021
    Assignee: Encore Dermatology, Inc.
    Inventors: Udhumansha Ubaidulla, Sateesh Kandavilli, Ajay Sunil Vairale, Jeffrey A. Wayne, Vijendra Nalamothu, Mistry Meghal, Refika Isil Pakunlu
  • Patent number: 10894775
    Abstract: In its many embodiments, the present invention provides certain piperidine compounds of the Formula (I): and pharmaceutically acceptable salts thereof, wherein X, Y, R1, R2, R3, L, R4, L1, Q, and R5 are as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-? receptor (LXR?) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: January 19, 2021
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Michael T. Rudd, Zhaoyang Meng, Jenny Wai, David Jonathan Bennett, Edward J. Brnardic, Nigel J. Liverton, Shawn J. Stachel, Yongxin Han, Paul Tempest, Jiuxiang Zhu, Xuewang Xu, Bin Zhu, Chuanman Huang
  • Patent number: 10888546
    Abstract: A pharmaceutical composition is described. The composition comprises: (i) a drug component comprising at least one pharmaceutically acceptable salt of giycopyrrolate; and (ii) a propellant component comprising 1,1-difluoroethane (HFA-152a).
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: January 12, 2021
    Assignee: MEXICHEM FLUOR S.A. DE C.V.
    Inventors: Stuart Corr, Timothy James Noakes
  • Patent number: 10889736
    Abstract: A polymer that can be used as a release coating or a release agent in an LAB, either of which can be provided in VOC-free form and which exhibits excellent release even after aging under high humidity, includes mer that contain pendent groups that include carbamate functionalities.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: January 12, 2021
    Assignee: OMNOVA Solutions Inc.
    Inventor: Joel E. Goldstein
  • Patent number: 10877024
    Abstract: The invention provides novel methods of determining or comparing potency of a test interferon relative to rSIFN-co (an interferon having therapeutic effects on solid tumors); methods of establishing substantial equivalence between a test interferon and rSIFN-co; as well as methods for determining potency of a test interferon, kits for determination of such methods, and an interferon or an interferon substitute having said activities.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: December 29, 2020
    Assignee: SUPERLAB FAR EAST LIMITED
    Inventor: Guangwen Wei
  • Patent number: 10869913
    Abstract: A system for delivering a therapeutic agent to a nasopharyngeal mucosa target comprises a foam generating mechanism, a gas, a therapeutic agent in liquid form that inhibits mucus production, and a delivery device. Actuation of the foam generating mechanism entraps gaseous bubbles from the gas in the liquid thereby forming a foam. The therapeutic agent is dispersed in the foam which has an expanded configuration adapted to fill a nasopharyngeal space and deliver the therapeutic agent to the mucosa targets. The delivery device is for delivering the foam to the nasopharyngeal space. The foam may also have a collapsed configuration for removal from the nasopharyngeal space or for concentration of the therapeutic agent onto the mucosa.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: December 22, 2020
    Assignee: The Foundry, LLC
    Inventors: John Morriss, Cary Reich, Hanson Gifford
  • Patent number: 10857159
    Abstract: The present invention provides a composition and method for treating various skin diseases. The composition is formulated as a foamable composition and includes the corticosteroid halobetasol.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: December 8, 2020
    Assignee: MAYNE PHARMA LLC
    Inventors: Robert T. Gauthier, James D. Hammer
  • Patent number: 10842845
    Abstract: The present disclosure provides methods for treating obstructive sleep apnea (OSA) and OSA induced cardiorespiratory diseases. The disclosure provides, inter alia, methods for treating or alleviating: OSA or OSA induced hypertension, cardiac arrhythmias, myocardial ischemia, sudden cardiac death or stroke, by administering oxytocin. The disclosure further provides methods for improving sleep satisfaction in OSA patients by administering oxytocin.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: November 24, 2020
    Assignee: THE GEORGE WASHINGTON UNIVERSITY
    Inventors: David Mendelowitz, Vivek Jain, Heather Jameson, Jay Shawn Kimbro
  • Patent number: 10835738
    Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: November 17, 2020
    Assignee: Oculeve, Inc.
    Inventors: Douglas Michael Ackermann, James Donald Loudin, John Wardle, Janusz Kuzma
  • Patent number: 10829543
    Abstract: The presently-disclosed subject matter relates to antibodies, compositions, and methods for inhibiting and treating virus infection in the respiratory tract and virus transmission through the respiratory tract. In particular, the presently-disclosed subject matter relates to inhibiting and treating virus infection in a subject using compositions and antibodies that trap viruses in mucus of the respiratory tract, thereby inhibiting transport of virus across or through mucus secretions.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: November 10, 2020
    Assignees: The University of North Carolina at Chapel Hill, The Johns Hopkins University
    Inventors: Samuel Lai, Ying-Ying Wang, Arthi Kannan, Kenetta Nunn, Durai Babu Subramani, Richard Cone, Bing Yang, Justin Mccallen
  • Patent number: 10806769
    Abstract: A topical cleansing composition for stimulating the production of antimicrobial peptides on the skin is disclosed. The topical cleansing composition includes an active ingredient comprising one or more of a natural extract and a polypeptide; one or more surfactants; and water. The topical cleansing composition increases the concentration of antimicrobial peptides on skin, as compared to an otherwise identical topical composition without the active ingredient.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: October 20, 2020
    Assignee: GOJO Industries, Inc.
    Inventors: Kegui Tian, Jessica Rae Tittl, Venkatesan V. Padyachi
  • Patent number: 10806701
    Abstract: Stable aerosol solution formulations comprising glycopyrronium bromide are useful for administration to patients with COPD and other respiratory conditions.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: October 20, 2020
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Sauro Bonelli, Francesca Usberti, Enrico Zambelli
  • Patent number: 10792256
    Abstract: A pharmaceutical composition is described. The composition comprises: (i) a drug component comprising at least one salmeterol compound selected from salmeterol and the pharmaceutically acceptable derivatives thereof; and (ii) a propellant component comprising 1,1-difluoroethane (HFA-152a).
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: October 6, 2020
    Assignee: MEXICHEM FLUOR S.A. DE C.V.
    Inventors: Stuart Corr, Timothy James Noakes
  • Patent number: 10785998
    Abstract: A combination of a method using a composition utilized together to disinfect and/or lubricate a fluid encompassing system. A single composition comprising a disinfectant and a lubricant comprises water-alcohol-glycerin-chlorhexidine gluconate. This composition is used together with a method of purging this fluid encompassing system, adding said composition into said system, and flushing/rinsing said system. This method ensures that this composition is not diluted and that this composition directly contacts the microbial contamination and biofilm in this system. This method using this composition maintains and controls this system's encompassing fluid chemical and physical properties by disinfecting and/or lubricating said fluid encompassing system and said system's fluid system components comprising of fluid conduit(s), and/or fluid reservoir(s), and/or valve(s), and/or device(s) that connect to this system's fluid system.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: September 29, 2020
    Inventors: Thad J. Overmyer, Michael Overmyer
  • Patent number: 10751483
    Abstract: A medicament delivery device has a syringe, a housing, a needle shield, a biasing member and one or more blocking members. The needle shield is biased axially forwardly by the biasing member so as to selectively cover a needle of the syringe. However, the biasing member is prevented from biasing the needle shield axially forwardly until a radial movement of the blocking members has occurred, which is precipitated by a forward axial movement of the syringe. Consequently, the forward movement of the syringe releases the needle shield to automatically make safe the device.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: August 25, 2020
    Assignee: Consort Medical PLC
    Inventors: Steven Hatch, Alastair Willoughby, Guy Moseley, Dan Garson
  • Patent number: 10736343
    Abstract: An antimicrobial composition for extending the shelf-life of water, feed or feed ingredients, comprising: water, a mixture of CrC18 organic acids, a mixture of CrC24 aldehydes, 5-25 wt. % pelargonic acid, and 5-30 wt. % trans-2-hexenal.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: August 11, 2020
    Assignee: ANITOX CORPORATION
    Inventors: Julio Pimentel, Kurt Richardson
  • Patent number: 10682414
    Abstract: Drug products adapted for nasal delivery comprising formulations with epinephrine and devices comprising such formulations are provided. Methods of treating anaphylaxis with epinephrine products are also provided.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: June 16, 2020
    Assignee: AEGIS THERAPEUTICS, LLC
    Inventors: Richard Lowenthal, Edward T. Maggio, Robert G. Bell, Pratik Shah
  • Patent number: 10682343
    Abstract: The present invention features compositions and methods for treatment of snoring. We describe compositions comprising an antihistamine or a pharmaceutically acceptable salt thereof and one or more dietary supplements or pharmaceutically acceptable salts thereof. The compositions can be administered to a subject suffering from snoring.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: June 16, 2020
    Inventors: James M. Hand, Linda M. Hand
  • Patent number: 10677782
    Abstract: The invention provides novel methods of determining or comparing potency of a test interferon relative to rSIFN-co (an interferon having therapeutic effects on solid tumors); methods of establishing substantial equivalence between a test interferon and rSIFN-co; methods for down-regulation of expression of Wnt-related receptors or co-receptors, such as LRP6/FZD6; down-regulation of expression of Wnt-related target genes, such as, Axin2, CD24, Survivin and/or ID2; inhibition of beta-catenin/TCF transcriptional activities; suppression of expression of beta-catenin; up-regulation of tumor suppressor genes, such as DKK-3, BATF2 and/or KLF4; inhibition of tumor cell viability in vitro; inhibition of tumor growth and metastases in vivo; inhibition of tumor cell migration, pseudopod formation, and colony formation in vitro; as well as methods for determining potency of a test interferon, kits for determination of such methods, and an interferon or an interferon substitute having said activities.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: June 9, 2020
    Assignee: SUPERLAB FAR EAST LIMITED
    Inventor: Guangwen Wei
  • Patent number: 10674722
    Abstract: Antimicrobial and foamable alcoholic compositions, where the compositions include at least about 40 wt. % of a C1-4 alcohol and one or more silane surfactants selected from (1) zwitterionic silane surfactants, (2) polyalkoxylated silane surfactants that contain at least one silane group and at least one polyalkylene oxide chain.
    Type: Grant
    Filed: November 1, 2018
    Date of Patent: June 9, 2020
    Assignee: GOJO Industries, Inc.
    Inventors: Evan D. Hillman, Daniel J. Lacks, Mitchell J. Cohen
  • Patent number: 10668018
    Abstract: A pharmaceutical solution for a medication delivery apparatus, especially a metered dose inhaler, is described. The pharmaceutical solution comprises: (a) a liquefied propellant component consisting essentially of and preferably consisting entirely of 1,1-difluoroethane (R-152a); (b) ethanol; and (c) a drug component dissolved in the propellant/ethanol mixture consisting of at least one drug selected from the group consisting of beclomethasone dipropionate (BDP) and fluticasone propionate (FP).
    Type: Grant
    Filed: January 16, 2019
    Date of Patent: June 2, 2020
    Assignee: MEXICHEM AMANCO HOLDING S.A. DE C.V.
    Inventors: Stuart Corr, Timothy James Noakes
  • Patent number: 10660914
    Abstract: A pharmaceutical composition has a stuffy nose deblocking activity. The composition includes a hyperosmolar aqueous solution of a non-ionic osmolality adjusting agent, optionally in combination with an ionic osmolality adjusting agent, wherein the composition further includes iota-carrageenan and/or kappa-carrageenan as an active antiviral ingredient in an antivirally effective amount, with the proviso that the composition in its ready-for-use formulation contains no more than 0-1.5% w/v of the ionic osmolality adjusting agent. The composition is useful for deblocking a stuffy nose and for prophylactic or therapeutic intervention of a number of viral infections of the upper respiratory tract.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: May 26, 2020
    Assignee: MARINOMED BIOTECH AG
    Inventors: Andreas Grassauer, Eva Prieschl-Grassauer, Angelika Bodenteich, Christiane Koller, Martina Morokutti-Kurz
  • Patent number: 10632266
    Abstract: Described herein are compositions, methods and an apparatus relating to the pulmonary delivery of an inhalable composition comprising caffeine, or a salt thereof, and a solvent selected from the group consisting of propylene glycol, glycerol, ethanol and a combination thereof.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: April 28, 2020
    Assignee: Ahkeo Ventures LLC
    Inventors: Kelly McNeal, Brent Skoda
  • Patent number: 10610512
    Abstract: Provided herein are embodiments related to metered dose inhalers and formulations for such inhalers. In some embodiments, the inhalers are configured so as to allow a more comfortable experience for the subject receiving the formulation. In some embodiments, the formulation comprises various ingredients, such as terpenes and/or waxes, which can further enhance the level of comfort for the subject receiving the formulation.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: April 7, 2020
    Assignee: Island Breeze Systems CA, LLC
    Inventors: Michael S. Hartman, James V. C. Boyles
  • Patent number: 10603268
    Abstract: The present invention relates to a hair composition comprising: (i) one or more polymers containing a silicone unit bearing alkoxy-(aminomethyl)-silyl functional groups; (ii) one or more nonionic fixing polymers and/or one or more anionic fixing polymers.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: March 31, 2020
    Assignee: L'OREAL
    Inventors: Gregory Plos, Nicolas Daubresse, Patrice Lerda, Valerie Favreau
  • Patent number: 10603262
    Abstract: The present invention provides a composition containing component (A): a compound represented by the formula (1) wherein each symbol is as described in the DESCRIPTION, or a salt thereof and component (B): a cationic surfactant, which is superior in the usability during rinsing, which makes the hair surface after treatment smooth and free of dry feeling, provides a uniform touch feeling from the root of the hair to the tip thereof, and can be utilized as an aqueous cosmetic.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: March 31, 2020
    Assignee: AJINOMOTO CO., INC.
    Inventors: Nana Haraya, Shun Kobayashi
  • Patent number: 10576070
    Abstract: Non-aqueous liquid compositions comprising nimodipine having improved stability over aqueous compositions comprising nimodipine are provided herein. Methods of improving neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured intracranial berry aneurysms with the non-aqueous liquid compositions of the present invention are also detailed herein.
    Type: Grant
    Filed: May 9, 2019
    Date of Patent: March 3, 2020
    Assignee: Arbor Pharmaceuticals, LLC
    Inventor: Hugh Greg Thomas
  • Patent number: 10576156
    Abstract: The present invention provides compositions and methods and for increasing the bioavailability of therapeutic agents in a subject. The compositions include at least one alkyl glycoside and at least one therapeutic agent, wherein the alkylglycoside has an alkyl chain length from about 10 to about 16 carbon atoms.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: March 3, 2020
    Assignee: Aegis Therapeutics, LLC
    Inventor: Edward T. Maggio
  • Patent number: 10555903
    Abstract: The present disclosure relates to a nebulization composition comprising tiotropium and formoterol for the treatment of inflammatory or obstructive airway disease. The present disclosure also relates to a process for preparing the composition.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: February 11, 2020
    Assignee: GLENMARK SPECIALTY S.A.
    Inventors: Ulhas R. Dhuppad, Ramprasad Murugan, Mahadeorao S. Rase, Franciscus Koppenhagen, Julianne Berry
  • Patent number: 10525005
    Abstract: Methods of delivering cromolyn to a patient in need thereof, methods of treating amyloid-associated conditions and inflammatory or allergic lung diseases, and packs and kits comprising cromolyn are described.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: January 7, 2020
    Assignee: The General Hospital Corporation
    Inventor: David R. Elmaleh
  • Patent number: 10525006
    Abstract: The invention relates to the prevention and/or treatment of a severe broncho-pulmonary disease by administering a solution formulation from a pressurized metered dose inhaler capable of providing therapeutical doses of two or more active drug substances to the lung, wherein all the active drug substances are fully dissolved in the formulation as well as the two or more active drug substances are delivered with substantially the same particle size distribution.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: January 7, 2020
    Assignee: CHIESI FARMACEUTICI S.P.A.
    Inventors: David Andrew Lewis, Brian John Meakin, Gaetano Brambilla
  • Patent number: 10493205
    Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: December 3, 2019
    Assignee: Battelle Memorial Institute
    Inventors: Eric C. Scribben, Steven M. Risser, Amy M. Heintz, Jeffrey L. Ellis, John D. Clay, Timothy M. Blum
  • Patent number: 10471040
    Abstract: The present invention relates generally to intranasal pharmaceutical compositions. In particular, the present invention is directed to sustained, enhanced delivery of pharmaceutical agents across the nasal mucosa for systemic drug delivery.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: November 12, 2019
    Assignee: Lachesis Biosciences Limited
    Inventor: Timothy Matthias Morgan
  • Patent number: 10449161
    Abstract: The invention provides microparticles for use in a pharmaceutical composition for pulmonary administration, each microparticle comprising a particle of an active substance having, on its surface, particles of a hydrophobic material suitable for delaying the dissolution of the active substance. The invention also provides a method for making the microparticles.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: October 22, 2019
    Assignee: VECTURA LIMITED
    Inventors: John Nicholas Staniforth, Haggis Harris, David Alexander Vodden Morton, Robin Bannister
  • Patent number: 10441552
    Abstract: This invention discloses anti-bacterial and anti-fungal compositions in spray form, in cream form, in liquid form, and in powder form. The anti-bacterial and anti-fungal compositions comprise cannabinoids, specifically cannabidiol, cannabigerol, tetrahydrocannabinol, tetracannabidivarin, and/or cannabidivarin for anti-bacterial and anti-fungal activities. The anti-bacterial and anti-fungal compositions may be used to treat toe nail fungus, MRSA infection, herpes virus infection, tinea pedis, burn wound infections, sun burns, diabetic infections, eczema, impetigo, dermatophytosis, psoriasis, itchy skin, atopic dermatitis, dandruff, and general topical infections.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: October 15, 2019
    Assignee: Axim Biotechnologies, Inc.
    Inventors: George E. Anastassov, Lekhram Changoer, Philippus Anne Van Damme
  • Patent number: 10426713
    Abstract: A method of treating hair or skin with a creamy foam. The method comprises dispensing a personal care composition from a mechanical foam dispenser as a dosage of foam, applying the dosage of foam to hair or skin, and rinsing the dosage of foam from hair or skin. The personal hair composition contains a surfactant system that is substantially free of sulfate-based surfactants. The personal hair composition has a viscosity of less than 60 cP and a lather volume greater than 77 cm3.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: October 1, 2019
    Assignee: The Procter and Gamble Company
    Inventors: Brian Xiaoqing Song, Ioannis Constantine Constantinides
  • Patent number: 10415001
    Abstract: The invention relates to mixtures having: components (a) having at least one fragrance of the formula (I) where R1=OC—R2, CH2OR3, C1-C8 open-chain or branched aliphatic radical, optionally substituted and/or unsaturated, with R2=an open-chain or branched aliphatic radical, optionally substituted and/or unsaturated, having 2-10 C atoms, with R3=an open-chain or branched aliphatic radical, optionally substituted and/or unsaturated, having 1-8 C atoms, and components (b) having at least one fragrance, different from the fragrances of component a, characterized in that the weight ratio of all components (a) to all components (b) is from 1:10 to 1:10000.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: September 17, 2019
    Assignee: SYMRISE AG
    Inventors: Erich Dilk, Edison Diaz, Pierre Kurzenne, Walter Kuhn
  • Patent number: 10398656
    Abstract: A composition comprising dimethyl sulfoxide (DMSO) as an effective agent useful for treating skin diseases or conditions caused by, associated with, or are complicated by microbial infection is disclosed.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: September 3, 2019
    Assignee: Veloce BioPharma, LLC
    Inventors: Nicholas J. Caramenico, III, Joseph Capriotti, Kara Capriotti
  • Patent number: 10376525
    Abstract: Treprostinil can be administered using a metered dose inhaler. Such administration provides a greater degree of autonomy to patients. Also disclosed are kits that include a metered dose inhaler containing a pharmaceutical formulation containing treprostinil.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: August 13, 2019
    Assignee: United Therapeutics Corporation
    Inventors: Horst Olschewski, Robert Roscigno, Lewis J. Rubin, Thomas Schmehl, Werner Seeger, Carl Sterritt, Robert Voswinckel
  • Patent number: 10376526
    Abstract: The present invention relates to a stable fixed dose aqueous pharmaceutical composition (e.g., contained in a container) for nasal administration to a human, comprising mometasone or its salt, olopatadine or its salt. The composition may further include a hydrocolloid. The invention also relates to a process for preparing the pharmaceutical composition, and the use of the pharmaceutical composition in the treatment of rhinitis in a subject.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: August 13, 2019
    Assignee: GLENMARK SPECIALTY S.A.
    Inventors: Ulhas R. Dhuppad, Ashok Katkurwar, Yashwant Gupta, Rajesh Ankam, Chandrakant Dhatrak
  • Patent number: 10369102
    Abstract: Unique foamable vehicles or carriers comprising at least one wax, waxy substance, counterpart or derivative, a stabilizer, water, and a propellant are provided. In some embodiments, the wax is a liquid wax. In some embodiments, the wax includes a solid wax and a liquid wax. The compositions are substantially free of crystals. The components are selected to provide a composition that is substantially resistant to aging and to phase separation, and/or can substantially solubilize and or stabilize active ingredients. Pharmaceutical and cosmetic compositions with potentially enhanced skin delivery and their uses are also provided.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: August 6, 2019
    Assignee: Foamix Pharmaceuticals Ltd.
    Inventors: Dov Tamarkin, Rita Keynan, David Schuz, Tal Berman