Organic Pressurized Fluid Patents (Class 424/45)
  • Patent number: 11320383
    Abstract: The present invention relates to a method for the determination of the film forming amines on surfaces by the detection of a colored complex. The invention also relates to the use of the absorber material for the detection of the film forming amines. The invention also relates to a kit of parts comprising the components capable of the determination of film forming amines.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: May 3, 2022
    Assignee: KURITA WATER INDUSTRIES LTD.
    Inventors: Julia Jasper, Kirstin Zimmer, Andre De Bache, Wolfgang Hater
  • Patent number: 11318112
    Abstract: A pharmaceutical composition is prepared from the following raw materials (in parts by weight): silybin (8.75-60), phospholipid (15-65), a Pu'er tea extract (25-200), and vitamin E (6.25-40). The composition has the effect of treating non-alcoholic fatty liver diseases.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: May 3, 2022
    Assignee: TASLY PHARMACEUTICAL GROUP CO., LTD.
    Inventors: He Sun, Xijun Yan, Naifeng Wu, Kaijing Yan, Yonghong Zhu, Shunnan Zhang, Xiaolin Bai, Xiaohui Ma, Yi He, Ting Li, Lei Li
  • Patent number: 11311493
    Abstract: This invention relates to methods of preparing nanotherapeutic compounds and compositions comprising nanotherapeutic compounds. The nanotherapeutic compounds prepared according to the methods provided herein are useful for the treatment of disease, for example, cancer, in a subject in need thereof.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: April 26, 2022
    Assignee: MAA Laboratories, Inc.
    Inventor: Anjani Kumar Jha
  • Patent number: 11311502
    Abstract: A pharmaceutical composition is described. The composition comprises: (i) a drug component comprising at least one salmeterol compound selected from salmeterol and the pharmaceutically acceptable derivatives thereof; and (ii) a propellant component comprising 1,1-difluoroethane (HFA-152a).
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: April 26, 2022
    Assignee: MEXICHEM FLUOR S.A. DE C.V.
    Inventors: Stuart Corr, Timothy James Noakes
  • Patent number: 11304992
    Abstract: A method for treating hyperglycemia and/or diabetes in a subject is provided. In particular, the method is directed for the treatment of patients with type 2 diabetes mellitus who have a fasting blood glucose concentration greater than about 8 mM, wherein the patient is administered a formulation comprising a GLP-1 molecule and a diketopiperazine by pulmonary inhalation with a dry powder inhalation system.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: April 19, 2022
    Assignee: MANNKIND CORPORATION
    Inventors: Donald Costello, Peter Richardson, Robert A. Baughman, Mark T. Marino
  • Patent number: 11291648
    Abstract: The present disclosure is directed to a composition comprising micronized cromolyn sodium, ?-lactose, and a salt of fatty acid, wherein the ?-lactose has a particle size distribution of D90 of 45-70 ?m, D50 of 10-35 ?m, and D10 of 2-13 ?m. The present disclosure is also directed to a method of treating Alzheimer's disease, amyloidosis-associated condition (AAC), traumatic brain injury, Huntington's disease, atherosclerosis, cytokine release syndrome (CRS), dementia, head injury, infection, neuroinflammation, prion disease, stroke, amyotrophic lateral sclerosis (ALS), Parkinson's disease, or asthma using the composition.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: April 5, 2022
    Assignees: The General Hospital Corporation, AZTherapies, Inc.
    Inventors: David R. Elmaleh, Juan B. Gonzalez
  • Patent number: 11260111
    Abstract: Disclosed are applications of a mussel adhesive protein or preparations thereof in suppression of skin inflammations. Specifically disclosed are applications of a mussel adhesive protein, preparations thereof and applications thereof in dermatitis, eczema, skin ulcer, technologies related to burns (comprising skin grafting), perniones, surgical incisions, herpes, abrasions, scars, psoriasis, erythema multiforme, skin damage after radiotherapy, skin cancers, folliculitis, urticaria and drug eruption, and applications in sunburn, polymorphous light eruption, pathological alopecia (comprising hair transplant), acne vulgaris, rosacea (that is, acne rosacea), and the like, and applications in the treatment of otitis externa.
    Type: Grant
    Filed: January 2, 2020
    Date of Patent: March 1, 2022
    Assignee: Jiangyin Bengt I. Samuelsson Institute of Life Science Co., Ltd.
    Inventors: Bengt Ingemar Samuelsson, Min Gao
  • Patent number: 11259521
    Abstract: Novel antimicrobial compositions and kits thereof containing these antimicrobial compositions, methods of manufacture and methods of use thereof are disclosed. The novel aqueous transdermal or topical delivery systems are useful, inter alia, for treatment of various microbial infections, including for use on tissue infections, particularly skin antisepsis and/or nasal mucosal tissue antisepsis to a mammalian host in need thereof.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: March 1, 2022
    Assignee: Infection Containment Company, LLC
    Inventors: Dennie W. Dyer, John A. Garruto
  • Patent number: 11246964
    Abstract: Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: February 15, 2022
    Assignee: Arsenal Medical, Inc.
    Inventors: Upma Sharma, Irina Gitlin, Gregory T. Zugates, Adam Rago, Parisa Zamiri, Rany Busold, Robert J. Caulkins, Toby Freyman, Quynh Pham, Changcheng You, Jeffrey Carbeck
  • Patent number: 11246878
    Abstract: Composition and methods for treating infectious and inflammatory diseases using saccharide based products and therapies. Products can be implemented as a nutritional supplement, a food, a feed, a food additive, a feed additive, a therapeutic product, a rehydration salt, or a rehydration solution. The present disclosure relates generally to the fields of compositions and products containing the compositions, and the use of the compositions or the products for preventing and/or treating infectious or inflammatory diseases or conditions in particular gastrointestinal and respiratory diseases (diarrhea and influenza infections) or inflammatory.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: February 15, 2022
    Assignee: B&H BIOTECHNOLOGIES, LLC
    Inventor: Huiru Wang
  • Patent number: 11241371
    Abstract: A skin protecting product that includes cyclopentasiloxane, disiloxane, octylacrylamide, acrylates, butylaminoethyl methacrylate copolymer, isopropyl myristate, hydroxypropyl gluconomide, hydroxyproply ammonium gluconate, phenoxyethanol, Cetearyl alcohol, cetyl alcohol, cetyl PPG, PPG-10/1 dimethicone, hydroxyethyl urea, zinc oxide, titanium oxide, fragrance such as perfumes or colognes, vitamin C, and isodecyl neopentanoate. The skin protecting product is applied daily along with sunscreen to help reduce the chance of skin damage related conditions and illnesses that result from sun exposure. The product is applied on hard to reach areas such as the scalp. The product is weightless, so the user is not bothered by the application of the product. The skin protecting product comes in various forms such as a spray, gel or lotion.
    Type: Grant
    Filed: February 18, 2020
    Date of Patent: February 8, 2022
    Inventor: Janis Isabel Carreras
  • Patent number: 11225654
    Abstract: Provided are methods and compositions for self-cleaning that include a lysozyme capable of decomposing a microbe, a substrate applied to a solid surface, and a linker moiety bound to an outer surface of said substrate and an active group of said digestive protein, said linker moiety between said lysozyme and said substrate and covalently linking said lysozyme to a surface of said substrate optionally by an amide bond.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: January 18, 2022
    Assignees: TOYOTA MOTOR CORPORATION, THE UNIVERSITY OF AKRON
    Inventors: Ping Wang, Minjuan Zhang, Hongfei Jia, Archana H. Trivedi, Masahiko Ishii
  • Patent number: 11219589
    Abstract: The invention provides a method of strengthening the fibres of oxidatively-treated hair, the method comprising the sequential steps of: (i) washing the oxidatively-treated hair; (ii) soaking the washed hair in an aqueous treatment composition, and (iii) drying the soaked hair; characterised in that the aqueous treatment composition comprises at least 1% N-acetyl glycine (by weight based on the total weight of the composition).15 The invention also provides the use of an aqueous treatment composition comprising at least 1% N-acetyl glycine (by weight based on the total weight of the composition), for the enhanced strengthening of oxidatively-treated hair fibres relative to virgin hair fibres.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: January 11, 2022
    Assignee: CONOPCO, INC
    Inventor: Prem Kumar Cheyalazhagan Paul
  • Patent number: 11213501
    Abstract: A compounded transdermal cream for the topical administration of a compounded therapy includes a first active agent selected from the group consisting of nabumetone in an amount between approximately 5.0% and approximately 25% by weight of the transdermal cream and amitriptyline in an amount between approximately 0.5% and approximately 4.0% by weight of the transdermal cream; a second active agent comprising a nerve depressant in an amount between approximately 5.0% and 15.0% by weight of the transdermal cream, wherein the nerve depressant is gabapentin; a third active agent comprising a local anesthetic in an amount between approximately 1.0% and approximately 7.0% by weight of the transdermal cream, wherein the local anesthetic comprises lidocaine and prilocaine; and dimethyl sulfoxide (DMSO).
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: January 4, 2022
    Assignee: CMPD LICENSING, LLC
    Inventor: Jay Richard Ray, II
  • Patent number: 11213500
    Abstract: A compounded transdermal cream for topical administration of a compounded therapy includes a nerve depressant such as gabapentin in an amount between approximately 5% and 15% by weight of the transdermal cream, an NSAID (Non-Steroidal Anti-Inflammatory Drug) such as nabumetone in an amount between approximately 5% and approximately 25% by weight of the transdermal cream, a tricyclic antidepressant such as amitriptyline in an amount between approximately 0.5% and approximately 4% by weight of the transdermal cream, a local anesthetic such as lidocaine and prilocaine in an amount between approximately 1% and approximately 7% by weight of the transdermal cream, and dimethyl sulfoxide (DMSO).
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: January 4, 2022
    Assignee: CMPD LICENSING, LLC
    Inventor: Jay Richard Ray, II
  • Patent number: 11209411
    Abstract: The invention generally relates to methods for analyzing stability of an active pharmaceutical agent. In certain aspects, the methods involve obtaining an active pharmaceutical agent, and distributing the active pharmaceutical agent into one or more microdroplets. The one or more microdroplets including the active pharmaceutical agent are then subjected to one or more conditions that force degradation of the active pharmaceutical agent in each of the one or more microdroplets. The one or more microdroplets are then analyzed to determine a ratio of the active pharmaceutical agent to that of a degradation product of the active pharmaceutical agent, thereby analyzing stability of an active pharmaceutical agent.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: December 28, 2021
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Roy Helmy, Yangjie Li, Yong Liu
  • Patent number: 11179366
    Abstract: A pharmaceutical composition is described. The composition may include: (i) a drug component including at least one pharmaceutically acceptable salt of glycopyrrolate; and (ii) a propellant component including 1,1-difluoroethane (HFA-152a).
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: November 23, 2021
    Assignee: MEXICHEM FLUOR S.A. DE C.V.
    Inventors: Stuart Corr, Timothy James Noakes
  • Patent number: 11154466
    Abstract: The invention relates to an aerosol device which contains a composition comprising: (i) one or more water-insoluble calcium salts, (ii) one or more fixing polymers, (iii) one or more surfactants, (iv) water, and (v) less than 20% by weight, relative to the total weight of the composition, of one or more propellants. It also relates to a process for shaping the hair and/or retaining the hairstyle, using the aerosol device of the invention.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: October 26, 2021
    Assignee: L'OREAL
    Inventors: Jonathan Gawtrey, Dorothée Pasquet
  • Patent number: 11141441
    Abstract: Bacterial hyperswarmers are disclosed for treatment, prevention and diagnosis of conditions such as intestinal inflammation.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: October 12, 2021
    Assignee: Albert Einstein College of Medicine
    Inventors: Sridhar Mani, Libusha Kelly, Hao Li
  • Patent number: 11129775
    Abstract: A method of treating hair or skin with a creamy foam. The method comprises dispensing a personal care composition from a mechanical foam dispenser as a dosage of foam, applying the dosage of foam to hair or skin, and rinsing the dosage of foam from hair or skin. The personal hair composition contains a surfactant system that is substantially free of sulfate-based surfactants. The personal hair composition has a viscosity of less than 60 cP and a lather volume greater than 77 cm3.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: September 28, 2021
    Assignee: The Procter and Gamble Company
    Inventors: Brian Xiaoqing Song, Ioannis Constantine Constantinides
  • Patent number: 11110043
    Abstract: The use of long-chain alkenones to impart desired characteristics in personal care compositions for topical applications is described. The preparation of mixtures long-chain alkenones and synthetic derivatives thereof is presented. Examples of compositions include abrasive soaps, with alkenones serving as natural exfoliating agents. Alkenones and their derivatives can serve as emollients, occlusive agents, encapsulating agents, stabilizing agents, binding agents, thickening agents, surfactants, and antimicrobials.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: September 7, 2021
    Assignees: WWU, Woods Hole Oceanographic Institution
    Inventors: Gregory W. O'Neil, Christopher M. Reddy
  • Patent number: 11112145
    Abstract: Artificial dense granules composed of a sterically stabilized liposome shell encapsulating a polyphosphate nanoparticle core are provided as are methods for their production and use in the treatment of a severe hemorrhagic event.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: September 7, 2021
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Ying Liu, Alexander Donovan
  • Patent number: 11110077
    Abstract: The present invention relates to topical pharmaceutical compositions of apremilast used for the treatment of psoriasis and/or psoriatic arthritis. It further relates to processes of preparation of the compositions and the method of use for these compositions.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: September 7, 2021
    Assignee: SARUDBHAVA FORMULATIONS PRIVATE LIMITED
    Inventor: Venkata Nookaraju Sreedharala
  • Patent number: 11103480
    Abstract: A pharmaceutical composition is described. The composition may include: (i) a drug component including at least one pharmaceutically acceptable salt of glycopyrrolate; and (ii) a propellant component including 1,1-difluoroethane (HFA-152a).
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: August 31, 2021
    Assignee: MEXICHEM FLUOR S.A. DE C.V.
    Inventors: Stuart Corr, Timothy James Noakes
  • Patent number: 11103448
    Abstract: The present invention relates to particles and to methods of making particles. In particular, the invention relates to methods of making composite active particles comprising a pharmaceutically active material for pulmonary inhalation, the method comprising a jet milling process.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: August 31, 2021
    Assignee: VECTURA LIMITED
    Inventors: David Morton, John Staniforth
  • Patent number: 11077076
    Abstract: A pharmaceutical composition is described. The composition comprises: (i) a drug component comprising at least one salmeterol compound selected from salmeterol and the pharmaceutically acceptable derivatives thereof; and (ii) a propellant component comprising 1,1-difluoroethane (HFA-152a).
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: August 3, 2021
    Assignee: MEXICHEM FLUOR S.A. DE C.V.
    Inventors: Stuart Corr, Timothy James Noakes
  • Patent number: 11046641
    Abstract: The present disclosure is directed in part to methods of treating fibrosis, e.g., hepatic fibrosis and/or intestinal fibrosis, comprising administering to a patient in need thereof an effective amount of a disclosed compound.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: June 29, 2021
    Assignee: Nogra Pharma Limited
    Inventors: Sergio Baroni, Salvatore Bellinvia, Francesca Viti
  • Patent number: 11033494
    Abstract: A method for preparing a card containing at least one sequestered compound is provided. The method includes preparing a first waxy phase, preparing a first volatile phase comprising a first sequestered compound, creating a first emulsion from the first waxy phase and the first volatile phase, depositing the first emulsion on the card, and cooling the first emulsion.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: June 15, 2021
    Assignee: Recursion Pharmaceuticals, Inc.
    Inventors: Jonathan Noble Betts-Lacroix, Daniel Ford, Laura Schaevitz
  • Patent number: 11028398
    Abstract: A fusion protein having a non-immunoglobulin polypeptide having a cysteine residue proximal to the C terminal thereof, and an immunoglobulin component with a mutated hinge region is provided. The mutation comprises a point mutated site corresponding in position to the position in a native hinge region of the cysteine residue located nearest the cysteine residue of the non-Ig component. The distance from the cysteine residue of the non-immunoglobulin polypeptide and any remaining cysteine residues of the mutated hinge region is sufficient to prevent the formation of a disulphide bond therebetween.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: June 8, 2021
    Assignee: NOVAGEN HOLDING CORPORATION
    Inventors: Haitao Wang, Yong Du, Rui Zhang, Jing Xu, Longbin Liu
  • Patent number: 11020542
    Abstract: A process and a nebulizer for dispensing a consecutively dose of medicament in the form of a mist, comprising: an energy source (ES), an air-conditioning volume, an air outlet fluidity connected to the air-containing volume, an air actuator adapted to release a flow of compressed air through the air outlet at such time as a predetermined ES pressure has been reached in the volume and at least two valve means in communication with the air actuator. The compressed air is released at a predetermined pressure of about 20 to about 100 psig. The valve means controls the actuation of the air actuator such that when a medication is nebulized, a mist distribution of a medication is formed having droplets size in the range of approximately 1? to approximately 7? which inhaled by a user at a set of predetermined intervals.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: June 1, 2021
    Assignee: Sanara Tech Ltd.
    Inventors: Eran Eilat, Joshua Altman
  • Patent number: 11020384
    Abstract: Pharmaceutical compositions comprising an antiarrhythmic agent for treatment of a heart condition via inhalation. Methods of treating a heart condition include administering by inhalation an effective amount of at least one antiarrhythmic pharmaceutical agent to a patient in need thereof. Nebulized drug product and kits are also disclosed.
    Type: Grant
    Filed: June 15, 2020
    Date of Patent: June 1, 2021
    Assignee: InCarda Therapeutics, Inc.
    Inventors: Michael Laird Hurrey, Luiz Belardinelli, Prashanti Madhavapeddi, Carlos Schuler
  • Patent number: 11007150
    Abstract: The inventive subject matter relates to a pharmaceutical aerosol product suitable for administration by oral or nasal inhalation and its use in the treatment of respiratory diseases, in particular in the treatment of children.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: May 18, 2021
    Assignee: COVIS PHARMA GMBH
    Inventors: Helgert Muller, Renate Engelstatter, Ulrich Bildmann, Andrea Bauer, Paul Mcglynn
  • Patent number: 11007185
    Abstract: Pharmaceutical compositions comprising an antiarrhythmic agent for treatment of a heart condition via inhalation. Methods of treating a heart condition include administering by inhalation an effective amount of at least one antiarrhythmic pharmaceutical agent to a patient in need thereof. Nebulized drug product and kits are also disclosed.
    Type: Grant
    Filed: June 15, 2020
    Date of Patent: May 18, 2021
    Assignee: InCarda Therapeutics, Inc.
    Inventors: Michael Laird Hurrey, Luiz Belardinelli, Prashanti Madhavapeddi, Carlos Schuler
  • Patent number: 10987288
    Abstract: A deep-sea water concentrate skin application kit of deep-sea active concentrate and skincare formula is provided. The deep-sea water concentrate skin application kit has the following properties of micronizing the skincare formulas immediately, and decreasing the surface tension of the deep-sea active concentrate immediately; furthermore, the deep-sea active concentrate can become a driving force for the permeability of the micronized skincare formulas. Therefore, the deep-sea water concentrate skin application kit can be more easily absorbed into the skin (dermis). A manufacturing method of the deep-sea water concentrate skin application kit is also provided to improve skin appearance.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: April 27, 2021
    Inventors: Yin-Ming Lo, Jane-Yi Su
  • Patent number: 10980920
    Abstract: Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: April 20, 2021
    Assignee: Arsenal Medical, Inc.
    Inventors: Upma Sharma, Irina Gitlin, Gregory T. Zugates, Adam Rago, Parisa Zamiri, Rany Busold, Robert J. Caulkins, Toby Freyman, Quynh Pham, Changcheng You, Jeffrey Carbeck
  • Patent number: 10973763
    Abstract: Inhalable pharmaceutical compositions can include an aqueous dispersion of particles including a hydrophobic bioactive agent (e.g., CoQ10) suitable for continuous aerosolization. Due to their chemical composition and methods of manufacture, the pharmaceutical compositions exhibit distinctive physicochemical properties that provide advantageous aerosol transmission and output.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: April 13, 2021
    Assignee: Berg LLC
    Inventors: Niven Rajin Narain, John Patrick McCook
  • Patent number: 10966925
    Abstract: The present invention is directed to epinephrine spray formulations. The present invention is further directed to methods of treating anaphylaxis by administering epinephrine spray formulations to subjects in need of such treatments.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: April 6, 2021
    Assignee: HIKMA PHARMACEUTICALS USA INC.
    Inventors: Thrimoorthy Potta, Craig Bastian, Ningxin Yan, Venkat Goskonda, Chandeshwari Chilampalli, Rachana Inavolu, Eshwaran Narayanan
  • Patent number: 10945950
    Abstract: The present invention relates to a liquid pharmaceutical composition suitable for administration by inhalation which comprises a diluent and a suspension of particles of 9,10-dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one (RPL554) or a pharmaceutically acceptable salt thereof. Also described is a liquid pharmaceutical composition according to the invention for use in the treatment of the human or animal body.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: March 16, 2021
    Assignee: VERONA PHARMA PLC
    Inventors: Peter Lionel Spargo, Edward James French, Phillip A. Haywood
  • Patent number: 10933018
    Abstract: Provided herein are novel isotretinoin formulations that provide an enhanced targeted dermal delivery system for the drug isotretinoin with improved thermodynamic activity using no to a small level of ethanol relative to existing isotretinoin gel products, and methods for treatment of ichthyosis and other skin conditions using the same.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: March 2, 2021
    Assignee: Timber Pharmaceuticals LLC
    Inventors: Zachary Rome, Charles Rodney Greenaway Evans, Marc Barry Brown, Francesco Caserta
  • Patent number: 10933019
    Abstract: The present invention relates to liquid pharmaceutical compositions comprising daptomycin, methods of providing such compositions and the use thereof. Provided herein are formulations comprising daptomycin, one or more polar protic solvents, and mixtures thereof. Formulations according to the present invention can further comprise polar aprotic solvent and/or source of calcium.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: March 2, 2021
    Assignee: XELLIA PHARMACEUTICALS APS
    Inventors: Tina Gjoni, Dubravka Strazic
  • Patent number: 10925924
    Abstract: Disclosed is a dry-powder peptide medicament with a non-typical concentration of carbohydrate excipient, as well as said medicament for use in treatment or prevention of a disease or condition, as well as methods for manufacturing said medicament.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: February 23, 2021
    Assignee: APEPTICO FORSCHUNG UND ENTWICKLUNG GMBH
    Inventor: Bernhard Fischer
  • Patent number: 10925689
    Abstract: The present invention relates to nitric oxide (NO)-releasing nail coating compositions, NO-releasing coatings, and methods of using the same, for example, to treat fungal infections of a nail. It is noted that aspects described with respect to one embodiment may be incorporated in different embodiments although not specifically described relative thereto. Provided according to embodiments of the invention are nitric oxide (NO)-releasing nail coating compositions and/or coatings.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: February 23, 2021
    Assignee: Novan, Inc.
    Inventors: Ryan Doxey, Yong Zhang
  • Patent number: 10905697
    Abstract: The application provides formulations for the topical administration of an active agent comprising at least one steroid, in the form of topical sprays that are propellant-free, and/or substantially non-foaming, and/or alcohol-free. The present application also provides processes for preparing such compositions and methods of using them in management of skin diseases or disorders such as psoriasis, dermatoses, and other associated skin diseases or disorders.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: February 2, 2021
    Assignee: Encore Dermatology, Inc.
    Inventors: Udhumansha Ubaidulla, Sateesh Kandavilli, Ajay Sunil Vairale, Jeffrey A. Wayne, Vijendra Nalamothu, Mistry Meghal, Refika Isil Pakunlu
  • Patent number: 10894775
    Abstract: In its many embodiments, the present invention provides certain piperidine compounds of the Formula (I): and pharmaceutically acceptable salts thereof, wherein X, Y, R1, R2, R3, L, R4, L1, Q, and R5 are as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-? receptor (LXR?) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: January 19, 2021
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Michael T. Rudd, Zhaoyang Meng, Jenny Wai, David Jonathan Bennett, Edward J. Brnardic, Nigel J. Liverton, Shawn J. Stachel, Yongxin Han, Paul Tempest, Jiuxiang Zhu, Xuewang Xu, Bin Zhu, Chuanman Huang
  • Patent number: 10888546
    Abstract: A pharmaceutical composition is described. The composition comprises: (i) a drug component comprising at least one pharmaceutically acceptable salt of giycopyrrolate; and (ii) a propellant component comprising 1,1-difluoroethane (HFA-152a).
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: January 12, 2021
    Assignee: MEXICHEM FLUOR S.A. DE C.V.
    Inventors: Stuart Corr, Timothy James Noakes
  • Patent number: 10889736
    Abstract: A polymer that can be used as a release coating or a release agent in an LAB, either of which can be provided in VOC-free form and which exhibits excellent release even after aging under high humidity, includes mer that contain pendent groups that include carbamate functionalities.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: January 12, 2021
    Assignee: OMNOVA Solutions Inc.
    Inventor: Joel E. Goldstein
  • Patent number: 10877024
    Abstract: The invention provides novel methods of determining or comparing potency of a test interferon relative to rSIFN-co (an interferon having therapeutic effects on solid tumors); methods of establishing substantial equivalence between a test interferon and rSIFN-co; as well as methods for determining potency of a test interferon, kits for determination of such methods, and an interferon or an interferon substitute having said activities.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: December 29, 2020
    Assignee: SUPERLAB FAR EAST LIMITED
    Inventor: Guangwen Wei
  • Patent number: 10869913
    Abstract: A system for delivering a therapeutic agent to a nasopharyngeal mucosa target comprises a foam generating mechanism, a gas, a therapeutic agent in liquid form that inhibits mucus production, and a delivery device. Actuation of the foam generating mechanism entraps gaseous bubbles from the gas in the liquid thereby forming a foam. The therapeutic agent is dispersed in the foam which has an expanded configuration adapted to fill a nasopharyngeal space and deliver the therapeutic agent to the mucosa targets. The delivery device is for delivering the foam to the nasopharyngeal space. The foam may also have a collapsed configuration for removal from the nasopharyngeal space or for concentration of the therapeutic agent onto the mucosa.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: December 22, 2020
    Assignee: The Foundry, LLC
    Inventors: John Morriss, Cary Reich, Hanson Gifford
  • Patent number: 10857159
    Abstract: The present invention provides a composition and method for treating various skin diseases. The composition is formulated as a foamable composition and includes the corticosteroid halobetasol.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: December 8, 2020
    Assignee: MAYNE PHARMA LLC
    Inventors: Robert T. Gauthier, James D. Hammer
  • Patent number: 10842845
    Abstract: The present disclosure provides methods for treating obstructive sleep apnea (OSA) and OSA induced cardiorespiratory diseases. The disclosure provides, inter alia, methods for treating or alleviating: OSA or OSA induced hypertension, cardiac arrhythmias, myocardial ischemia, sudden cardiac death or stroke, by administering oxytocin. The disclosure further provides methods for improving sleep satisfaction in OSA patients by administering oxytocin.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: November 24, 2020
    Assignee: THE GEORGE WASHINGTON UNIVERSITY
    Inventors: David Mendelowitz, Vivek Jain, Heather Jameson, Jay Shawn Kimbro