Tampon Patents (Class 424/431)
  • Patent number: 10722663
    Abstract: A humidification system has a tube configured to transport gases. The tube is configured to be soaked prior to use and has a bead to hold liquid. Heat applied to the bead causes the liquid to be released as vapour. Gases flowing through the tube are heated and humidified by the vapour.
    Type: Grant
    Filed: February 6, 2016
    Date of Patent: July 28, 2020
    Assignee: Fisher & Paykel Healthcare Limited
    Inventors: Richard John Boyes, Christian Francis Fischer, Joseph Patrick Walter Strevens, Elmo Benson Stoks, Jayananda Mallinson
  • Patent number: 9855144
    Abstract: A penile prosthetic includes an insertion tool contained inside of an inflatable bladder of a penile implant. The penile implant is sized for insertion into a dilated corpora cavernosum of a penis. The penile implant has a proximal tip that is insertable into the crus penis, with the inflatable bladder connected to the proximal tip. The inflatable bladder has a first column strength and includes a distal tip that is insertable into the glans penis. The insertion tool provides the inflatable bladder with an effective column strength that is greater than the first column strength.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: January 2, 2018
    Assignee: Coloplast A/S
    Inventors: Thomas Kubalak, Donald Wolf
  • Patent number: 9101635
    Abstract: Organic compounds showing the ability to inhibit viral glycoprotein (GP)-mediated entry of a filovirus into a host cell are disclosed. The disclosed filovirus entry inhibitor compounds are useful for treating, preventing, or reducing the spread of infections by filovirus including the type species Marburg virus (MARV) and Ebola virus (EBOV). Preferred inhibitors of the invention provide therapeutic agents for combating the Ivory Coast, Sudan, Zaire, Bundibugyo, and Reston Ebola virus strains.
    Type: Grant
    Filed: July 10, 2010
    Date of Patent: August 11, 2015
    Assignee: MICROBIOTIX, INC.
    Inventors: Arnab Basu, Debra M. Mills, Norton P. Peet, John D. Williams
  • Patent number: 8999371
    Abstract: Provided herein are compositions for applying a reference marker pattern or grid to the surface of an object to be imaged three-dimensionally. These compositions can be quick drying for ease of use. Methods of use of the compositions are also provided as well as devices and kits for the application of the compositions.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: April 7, 2015
    Assignee: Arges Imaging, Inc.
    Inventors: Jian Lu, David Licata
  • Patent number: 8980303
    Abstract: The invention relates to medicine and pharmacology, more particularly to a pharmaceutical composition in the form of vaginal suppositories for treating candidal vaginitis and vulvovaginitis, containing antimycotics and prebiotics. The contents of the composition for therapeutic use make it possible to achieve the synergistic effect of stimulating the growth of the normal vaginal microflora through the presence of prebiotics and inhibiting the growth and eliminating pathogenic Candida fungi through the presence of modern antimycotics. Furthermore, the composition substantially contains such antimycotics to which representatives of the normal flora, i.e. lactobacilli and bifidobacteria, are insensitive. The method for treating mycetogenous or bacterial vaginosis, vaginitis and vulvovaginitis is carried out with the aid of the antimycotic and prebiotic pharmaceutical composition in a medicinal form for local application.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: March 17, 2015
    Assignee: Lugs International Ltd.
    Inventors: Aleksander Vladimirovich Dikovskiy, Oleg Valentinovich Dorozhko, Anatolievich Bor Rudoi
  • Patent number: 8815925
    Abstract: The invention relates to the use of an antimycotic agent and an epithelial cell or endothelial cell adhesion inhibitor for producing a combination drug for the topical treatment of Candida mycoses selected from vulvovaginal candidiasis, oropharyngeal candidiasis (oral thrush), diaper dermatitis (diaper thrush) and intertriginous (Candida) eczema.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: August 26, 2014
    Inventors: Christian Noe, Marion Noe-Letschnig
  • Patent number: 8764715
    Abstract: Test methods for assessing irritation of portions of skin are provided. The method may include irritating a portion of skin by contacting the portion of skin with a chemical irritant; irritating the portion of skin by physical irritation; and assessing erythema or dryness of the portion of skin after irritating the steps. Alternatively, the method may include irritating a portion of skin with a chemical irritant; irritating the portion of skin by physical irritation; treating the irritated portion of skin by wiping the irritated portion of skin with a test sample; and assessing erythema or dryness of the portion of skin after the wiping step. A method of irritating a portion of skin to assess one of erythema and dryness may include irritating a portion of skin with a chemical irritant and irritating the portion of skin by physical irritation.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: July 1, 2014
    Assignee: The Procter & Gamble Comapny
    Inventor: Miranda Aref Farage
  • Patent number: 8728511
    Abstract: Controlled release melatonin formulations are useful for imparting avoidance of mood depression which may be associated with administration of melatonin in conventional form comprising. Particular embodiments of methods use formulations designed to release melatonin according to a profile that simulates a normal endogenous melatonin nocturnal profile. The methods also include co-administration with additional medicaments.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: May 20, 2014
    Assignee: Neurim Pharmaceuticals (1991) Ltd.
    Inventors: Nava Zisapel, Moshe Laudon
  • Publication number: 20140030312
    Abstract: The invention relates to the use of an antimycotic agent and an epithelial cell or endothelial cell adhesion inhibitor for producing a combination drug for the topical treatment of Candida mycoses selected from vulvovaginal candidiasis, oropharyngeal candidiasis (oral thrush), diaper dermatitis (diaper thrush) and intertriginous (Candida) eczema.
    Type: Application
    Filed: October 2, 2013
    Publication date: January 30, 2014
    Inventors: Christian Noe, Marion Noe-Letschnig
  • Publication number: 20130345678
    Abstract: A method, medicated feminine sanitary products and compositions for reducing menstrual blood loss in a female are provided. The method comprises delivering an active agent to the uterine cavity by administering intravaginally to the female a therapeutically effective amount of the active agent on a medicated feminine sanitary product during menstrual bleeding, wherein the medicated feminine sanitary product is routinely utilized to absorb the menstrual flow, wherein the active agent is incorporated in the medicated feminine sanitary product as a pharmaceutically acceptable composition, the active agent is any of an antifibrinolytic and a hemostatic agent.
    Type: Application
    Filed: August 22, 2013
    Publication date: December 26, 2013
    Applicant: ARSTAT Inc.
    Inventor: Arkady RUBIN
  • Patent number: 8603513
    Abstract: Articles comprising one or more calcium salts are provided. The articles can contain one or more calcium salts in an amount effective to reduce the production of TSST-1 by at least about 50% when measured by the Shake Flask Method. In certain embodiments, the one or more calcium salts can be substantially non-lethal to Staphylococcus aureus when measured by the Shake Flask Method, and/or to Lactobacillus crispatus, Lactobacillus gasseri, and/or Lactobacillus iners when measured by the Maximum Tolerated Dose Test.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: December 10, 2013
    Assignee: The Procter & Gamble Company
    Inventors: Thomas Ward Osborn, III, Fancheng Wang, Kimberly Ann Nemeth, Catherine Cornick Davis
  • Patent number: 8552042
    Abstract: The invention relates to the use of an antimycotic agent and an epithelial cell or endothelial cell adhesion inhibitor for producing a combination drug for the topical treatment of Candida mycoses selected from vulvovaginal candidiasis, oropharyngeal candidiasis (oral thrush), diaper dermatitis (diaper thrush) and intertriginous (Candida) eczema.
    Type: Grant
    Filed: May 10, 2007
    Date of Patent: October 8, 2013
    Inventors: Christian Noe, Marion Noe
  • Patent number: 8518434
    Abstract: This invention provides a spermicidally and virucidally effective, vaginally applicable formulation, having the following approximate composition of essential ingredients: at least one benzalkonium chloride, in an amount from 0.05 to 0-0.2%; at least one spermicide selected from the group consisting of nonoxynols in an amount of from 0.05-12%, octoxynol-9 in an amount of from 0.05-4%, and triclosan in an amount from 0.05-2%; a biologically acceptable emollient, in an amount from 1-5%; hydroxypropyimethyl cellulose, in an amount from 0.1-3%; sodium carbomer, in an amount from 0.1-1%; de-ionized water, making up the balance. The composition has the attributes of (a) a semi-solid, essentially clear gel consistency and appearance, and (b) the ability to maintain a presence in the human vagina in the presence of mucous secretions therein, in virucidally effective amounts, for at least 24 hours after application thereto.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: August 27, 2013
    Assignee: St. Michael's Medical, Inc.
    Inventors: George M. Livingston, David B. Thornburgh, Jeffrey Longmore
  • Publication number: 20130136784
    Abstract: A method utilizing a dissolvable device for the internal delivery of medication and more particularly to the use of fibers or non-woven fabrics made of a safe polymer material incorporating a medication that is released by dissolution of the fibers or non-woven fabrics over time, and more particularly a treatment method for controlling or regulating the pH in the vagina by stabilizing and adjusting the pH in the vagina by minimizing the impact of the vaginal flora.
    Type: Application
    Filed: January 23, 2013
    Publication date: May 30, 2013
    Inventor: Robert J. Staab
  • Patent number: 8449492
    Abstract: An applicator having an enhanced grip portion. The applicator can include a barrel portion having an insertion end, a withdrawal end, and a barrel exterior surface, the barrel exterior surface being a barrel color, a grip portion positioned opposite the insertion end having a grip exterior surface, and a plunger having a plunger exterior surface. The applicator can further include gripping indicia disposed substantially on the grip exterior surface. The gripping indicia can include visual indicia and/or tactile indicia.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: May 28, 2013
    Assignee: The Procter & Gamble Company
    Inventors: Raymond Albert Sargent, Jr., Devin William Baldridge, David Andrew Dalton, Richard Perez, Margaret Henderson Hasse, Diana Lynn Gann
  • Patent number: 8425890
    Abstract: An odor-controlling bodily fluid absorbent member comprises (a) an absorbent material or substrate; and (b) a halo active aromatic sulfonamide compound of Formula (I): wherein R1, R2, R3, R4, R5, X, M, and n are as described herein; and wherein at least one of R1, R2, R3, R4, and R5 is not hydrogen. The absorbent member effectively controls odor arising from various body fluids.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: April 23, 2013
    Inventors: David J. Schneider, Charles A. Schneider
  • Patent number: 8388996
    Abstract: A method is provided for manufacturing a medicated tampon assembly having a tampon body, the method including applying a formulation including a therapeutic agent to a substrate to produce a plurality of dosage forms; separating one of the dosage forms from the substrate; and coupling one of the dosage forms to the tampon body. A medicated tampon assembly is provided including a dosage form including a formulation including a therapeutic agent; a substrate portion separated from a substrate, wherein the substrate portion is coupled to the dosage form; and a tampon body having a distal end, wherein the substrate portion is coupled to the distal end of the tampon body.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: March 5, 2013
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Steven C. Gehling, Gregory J. Rajala, James D. Milner, Dennis S. Everhart
  • Patent number: 8226972
    Abstract: Drug delivery compositions which are suitable for vaginal administration for the treatment of diseases and disorders in the urogenital tract are described. The compositions may be in the form of a tablet, liquid suspension or dispersion, dried powder, topical ointment, cream, foam, suppository, or aerosol. The drug delivery compositions are administered directly to the vagina and do not require the use of a solid device. This method of administration reduces the systematic levels of the drugs.
    Type: Grant
    Filed: December 19, 2002
    Date of Patent: July 24, 2012
    Assignee: FemmePharma Holding Company, Inc.
    Inventors: Gerianne Tringali DiPiano, John A. Ziemniak, Thomas Janicki
  • Patent number: 8182455
    Abstract: A method of capturing bodily fluid in a mammalian body includes inserting the fluid management device into the mammalian body and transporting bodily fluid. The bodily fluid is transferred via at least one fluid transport element that is capable of interfacing with a mammalian body element to provide a substantially uninterrupted fluid conduit. The fluid conduit provides a fluid path between at least one fluid transport element and the storage element. A distal portion of the at least one fluid transport element is capable of extending away from the fluid storage element.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: May 22, 2012
    Assignee: McNeil-PPC, Inc.
    Inventors: Samuel Carasso, David J. Chase, Erin Marsee, Mari Hou, Tara Glasgow
  • Patent number: 8153582
    Abstract: A personal-care article, for receiving body exudates, having a self-assembling peptide is provided.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: April 10, 2012
    Assignee: The Procter and Gamble Company
    Inventor: Giovanni Carlucci
  • Patent number: 8092815
    Abstract: Provided are articles containing a solid surface material with an antimicrobial agent in a thermoset and/or thermoplastic resin matrix, wherein the antimicrobial agent comprises a chitosan-metal complex.
    Type: Grant
    Filed: April 22, 2008
    Date of Patent: January 10, 2012
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Subramaniam Sabesan
  • Patent number: 8075512
    Abstract: An applicator having an enhanced grip portion. The applicator can include a barrel portion having an insertion end, a withdrawal end, and a barrel exterior surface, the barrel exterior surface being a barrel color, a grip portion positioned opposite the insertion end having a grip exterior surface, and a plunger having a plunger exterior surface. The applicator can further include gripping indicia disposed substantially on the grip exterior surface. The gripping indicia can include visual indicia and/or tactile indicia.
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: December 13, 2011
    Assignee: The Procter & Gamble Company
    Inventors: Raymond Albert Sargent, Jr., Devin William Baldridge, David Andrew Dalton, Richard Perez, Margaret Henderson Hasse, Diana Lynn Gann
  • Publication number: 20110280922
    Abstract: The invention relates to a therapeutic device for the delivery of therapeutic agents, e.g. a peptide such as leuprolide, via the vagina to a female mammal. In some embodiments, the invention also relates to methods for the treatment of obesity and eating disorders, diabetes, multiple sclerosis (MS), endometriosis, uterine fibroids, polycystic ovarian disease, various cancers such as breast cancer, acne, hirsutism, microbial or fungal or viral infections such as bacterial vaginosis or AIDS/HIV, and chronic diseases using a disclosed vaginal device.
    Type: Application
    Filed: November 9, 2009
    Publication date: November 17, 2011
    Applicant: Combinent Biomedical Systems, Inc.
    Inventors: Eyal S. Ron, William F. Crowley, Robert Langer, Surajit K. Biswas, Quentin Baca, Armen Tashjian, Preston H. Saunders
  • Patent number: 7993667
    Abstract: A method is provided for manufacturing a medicated tampon assembly having a tampon body, the method including applying a formulation including a therapeutic agent to a substrate to produce a plurality of dosage forms; separating one of the dosage forms from the substrate; and coupling one of the dosage forms to the tampon body. A medicated tampon assembly is provided including a dosage form including a formulation including a therapeutic agent; a substrate portion separated from a substrate, wherein the substrate portion is coupled to the dosage form; and a tampon body having a distal end, wherein the substrate portion is coupled to the distal end of the tampon body.
    Type: Grant
    Filed: March 25, 2005
    Date of Patent: August 9, 2011
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Steven C. Gehling, Gregory J. Rajala, James D. Milner, Dennis S. Everhart
  • Publication number: 20110189258
    Abstract: A method of inhibiting double-stranded DNA virus infection is disclosed. In one embodiment, the method involves exposing a papillomavirus to an effective amount of an inhibitor selected from the group of G1, S, G2, and M cell cycle inhibitors. In another embodiment, the method involves administering an inhibitor selected from the group of G1, S, G2, and M cell cycle inhibitors to a susceptible tissue or cell.
    Type: Application
    Filed: June 29, 2009
    Publication date: August 4, 2011
    Inventors: Dohun Pyeon, Paul F. Lambert, Shane Pearce, Paul G. Ahlquist
  • Publication number: 20110165220
    Abstract: A method of inhibiting HPV virus infection is disclosed. In one embodiment, the method involves exposing a papillomavirus to an effective amount of a compound selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14. In another embodiment, the method involves administering an inhibitor selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14 to a susceptible tissue or cell.
    Type: Application
    Filed: May 29, 2009
    Publication date: July 7, 2011
    Inventors: Paul F. Lambert, Paul G. Ahlquist, Dohun Pyeon, Hao Shun Huang
  • Patent number: 7906478
    Abstract: A personal-care article, for receiving body exudates, having a self-assembling peptide is provided.
    Type: Grant
    Filed: July 20, 2007
    Date of Patent: March 15, 2011
    Assignee: The Procter & Gamble Company
    Inventor: Giovanni Carlucci
  • Publication number: 20100285095
    Abstract: A hygiene article having calcium sugar acid salt is provided. The calcium sugar acid salt reduces the production of Toxic Shock Syndrome Toxin-1 (TSST-1) by S. aureus.
    Type: Application
    Filed: May 5, 2009
    Publication date: November 11, 2010
    Inventors: Kimberly Ann Nemeth, Thomas Ward Osborn, III, Fancheng Wang
  • Publication number: 20100285096
    Abstract: A hygiene article having calcium sugar phosphate is provided. The calcium sugar phosphate reduces the production of Toxic Shock Syndrome Toxin-1 (TSST-1) by Staphylococcus aureus.
    Type: Application
    Filed: May 5, 2009
    Publication date: November 11, 2010
    Inventors: Fancheng Wang, Kimberly Ann Nemeth, Thomas Ward Osborn, III
  • Publication number: 20100278725
    Abstract: The present invention is directed to an implantable device comprising a biocompatible and biodegradable matrix impregnated with a bioactive complex suitable for selectively targeting the lymphatic system, wherein the bioactive complex comprises one or more particle forming materials and one or more bioactive agents. The invention is further directed to methods of using and the process of preparing, the implantable device.
    Type: Application
    Filed: August 14, 2006
    Publication date: November 4, 2010
    Inventors: Jiang Liu, Michael Richard Johnston, Xiao Yu Wu
  • Publication number: 20100136089
    Abstract: The application of active ingredients, exemplified by GML, to absorbent fibers, such as rayon fibers, used in tampon manufacture at very low levels has been found to maintain efficacy in the inhibition of the production of toxic shock syndrome toxin one (TSST-1) produced by S. aureus without overtly killing the microorganism to achieve the desired reduction while avoiding undesired test results that suggest the presence of “impurities” in some jurisdictions.
    Type: Application
    Filed: November 20, 2009
    Publication date: June 3, 2010
    Inventors: Linda M. PIERSON, Susan K. Brown-Skrobot, Ching-Yun M. Yang
  • Publication number: 20100136088
    Abstract: In a tampon device (100) for insertion into the vulva, with a packing (110) of absorbent substance for taking up menstrual fluid, problems associated with menstruation, such as painful muscle tension and cramps in the area of the vulvar musculature, are alleviated or eliminated by the fact that a magnetic substance (120) interacting with the earth's magnetic field is integrated into the packing (110).
    Type: Application
    Filed: June 23, 2007
    Publication date: June 3, 2010
    Inventor: Christian Sulger
  • Patent number: 7691403
    Abstract: Non-absorbent articles containing an additive are disclosed. The non-absorbent articles include an effective amount of an inhibitory compound such as cerulenin, triclosan, or hexachloroprene, for example, to substantially inhibit the production of TSST-1 by Gram positive bacteria.
    Type: Grant
    Filed: October 16, 2002
    Date of Patent: April 6, 2010
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Rae Ellen Syverson, Richard A. Proctor
  • Patent number: 7670606
    Abstract: A vaginal care composition is introduced directly into the vagina in the form of an ovule, a cream or an ointment or with a tampon or which is brought into a position outside the vagina on a panty liner. The composition comprises viable Lactobacillus or Bifidobacterium microorganisms, non-viable Saccharomyces cultures, saccharide(s), vitamin A, and zinc.
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: March 2, 2010
    Inventor: Peter-Hansen Volkmann
  • Patent number: 7666160
    Abstract: An applicator for introducing a therapeutic substance into a body cavity of a subject in need of the therapeutic substance is provided. The applicator has the look and feel of a conventional tampon applicator but delivers a therapeutic substance. Generally, the applicator has a first outer member having a shape suitable for insertion into a body cavity of a mammal and has a dispensing end and a second end distal to the dispensing end. A second inner member is coaxially and slidably housed within the first member such that one end of the second inner member is within the first member. The applicator of the present invention also has at least one aperture located in a side wall of the outer member. The aperture is located on the side wall of the outer member between the dispensing end and the second end of the outer member.
    Type: Grant
    Filed: December 29, 2006
    Date of Patent: February 23, 2010
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Gregory J. Rajala, Daniel James Heuer, Steven Craig Gehling
  • Publication number: 20090306707
    Abstract: A method of joining and/or scaling tissues in a surgical procedure or medical treatment, comprising the steps of: (1) applying a matrix protein, a photoactivatable metal-ligand complex and an electron acceptor to a tissue portion; (2) irradiating said tissue portion to photactivate the photoactivatable metal-ligand complex: thereby initiating a cross-linking reaction of the matrix protein to seal said tissue portion or join said tissue portion to an adjacent tissue portion.
    Type: Application
    Filed: February 14, 2007
    Publication date: December 10, 2009
    Inventors: Alan George Brownlee, Christopher Malcolm Elvin
  • Publication number: 20090297585
    Abstract: pH modulated films and methods of their preparation. The film compositions include at least one component having a non-neutral pH when combined with water; and a pH modulated polymer system selected to reduce or prevent synerisis when combined with the non-neutral component in combination with aqueous media. The films demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, extrusion process, or other process that maintains the required uniformity of the film.
    Type: Application
    Filed: May 30, 2008
    Publication date: December 3, 2009
    Inventors: Garry L. Meyers, Giovanni M. Pauletti, Kishorkumar Desai
  • Publication number: 20090208558
    Abstract: The invention relates to the use of an antimycotic agent and an epithelial cell or endothelial cell adhesion inhibitor for producing a combination drug for the topical treatment of Candida mycoses selected from vulvovaginal candidiasis, oropharyngeal candidiasis (oral thrush), diaper dermatitis (diaper thrush) and intertriginous (Candida) eczema.
    Type: Application
    Filed: May 10, 2007
    Publication date: August 20, 2009
    Applicant: PHARMACON-FORSCHUNG UND BERATUNG GMBH
    Inventors: Christian Noe, Marion Noe
  • Patent number: 7572864
    Abstract: The invention relates to absorbent, cross-linked polymers based on partially neutralized, monoethylenically unsaturated monomers that bear acidic groups. Said polymers exhibit improved properties with regard to their ability to transport liquids in a swollen state. The surface of the polymers is postreticulated, using a combination of an organic cross-linking compound, excluding polyols, and a cation that is in salt form in an aqueous solution.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: August 11, 2009
    Assignee: Stockhausen GbmH
    Inventors: Richard Mertens, Harren Jōrg
  • Publication number: 20090186057
    Abstract: Compositions including an isolated Bacillus species, spores or an extracellular product of B. coagulans, suitable for topical application, for inhibiting growth of yeast, fungus, bacteria or Herpes simplex virus are disclosed. Methods of inhibiting growth of yeast, fungus, bacteria or Herpes simplex virus by topical application of compositions that include an isolated Bacillus species, spores or an extracellular product of a B. coagulans strain are disclosed.
    Type: Application
    Filed: February 12, 2009
    Publication date: July 23, 2009
    Applicant: Ganeden Biotech, Incorporated
    Inventors: Sean Farmer, Robert J. Mikhail
  • Publication number: 20090104249
    Abstract: The invention provides an exotoxin inhibitory factor, compositions containing the factor, methods of using the compositions.
    Type: Application
    Filed: December 23, 2005
    Publication date: April 23, 2009
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Patrick M. Schlievert, Marnie L. Peterson
  • Publication number: 20090074839
    Abstract: Compositions having synergistic effective amounts of one or more antibacterial agents, a nitroimidazole, and/or a sulfonamide or a molecule or compound having folic acid antagonist effect and nitroimidazole substitution in addition, with or without an antifungal agent effective against a Candida species. The compositions are particularly useful in the treatment of genitourinary infections and their extragenital complications. Vaccination against pathogen microbes of the vagina provides a stronger and longer immune response, then the infection.
    Type: Application
    Filed: November 20, 2008
    Publication date: March 19, 2009
    Inventor: Marton Milankovits
  • Publication number: 20090035353
    Abstract: Non-absorbent articles containing an additive are disclosed. The non-absorbent articles include an effective amount of an inhibitory compound such as cerulenin, triclosan, or hexachloroprene, for example, to substantially inhibit the production of TSST-1 by Gram positive bacteria.
    Type: Application
    Filed: October 16, 2008
    Publication date: February 5, 2009
    Applicant: KIMBERLY-CLARK WORLDWIDE, INC.
    Inventors: Rae Ellen Syverson, Richard A. Proctor
  • Patent number: 7442179
    Abstract: A pre-fill vaginal applicator comprising a tubular barrel having an open end and a dispensing end provided with at least one dispensing opening formed therein. A selectively removable closure, such as a snap cap or threaded cap, closes the dispensing end of the barrel. A resilient piston is selectively slidably positioned in the barrel and has an outer surface which is in sealing contact with the inner surface of the barrel to define a medication reservoir between the piston and dispensing end of the barrel. An elongated plunger is adapted to be inserted into the open end of the barrel so that the inner end thereof may be detachably connected to the piston. After the plunger has been connected to the piston, inward movement of the plunger causes the piston to force medication from the medication reservoir outwardly through the dispensing opening. Outward movement of the plunger with respect to the piston causes the plunger to disconnect from the piston.
    Type: Grant
    Filed: September 23, 2003
    Date of Patent: October 28, 2008
    Inventor: Troy M. Just
  • Publication number: 20080254098
    Abstract: A method and apparatus of fortifying a population of fertile age women with folic acid to reduce the incidence of neural tube birth defects involves placing folic acid either in powder, microcapsule, gel, cream, tablet, capsule or other form in or on a feminine hygiene product such as a tampon or a menstrual pad and making such products available to the population of women so that their normal use of the tampons or other feminine hygiene products will result in absorption of a sufficient amount of folic acid to satisfy RDA requirements for women who may or have become pregnant. In certain embodiments, vitamin B12 and/or other nutrients or ingredients are added to the folic acid vehicle.
    Type: Application
    Filed: April 11, 2008
    Publication date: October 16, 2008
    Inventors: Shelley R. Ehrlich, Steven E. Sabbagh
  • Publication number: 20080248087
    Abstract: An absorbent article has an absorbent material and an outer surface including an inhibitor which is partially bound to the absorbent material and substantially inhibits the colonization of bacteria within the absorbent article. An absorbent article has an absorbent material. The absorbent material has an outer surface. The absorbent article includes a pre-toxin limiting agent which is partially bound to the absorbent material and substantially retards the production of bacteria-produced toxins by the bacteria residing within the absorbent article. An absorbent article has an absorbent material. The absorbent material has an outer surface. The absorbent article includes a toxin enclosing agent. The toxin enclosing agent substantially inhibits the migration of toxin outwardly from within the absorbent article towards the outer surface of the absorbent article.
    Type: Application
    Filed: June 18, 2008
    Publication date: October 9, 2008
    Inventors: Donna Rene Hill, Thomas Ward Osborn, Catherine Cornick Davis
  • Publication number: 20080206309
    Abstract: A method of treating menorrhagia and/or dysmenorrhoea in a patient the method comprising administering to the patient an antagonist of a prostaglandin EP2 and/or EP4 receptor. Preferably the patient is a human female.
    Type: Application
    Filed: April 14, 2008
    Publication date: August 28, 2008
    Applicant: MEDICAL RESEARCH COUNCIL
    Inventors: Henry Nicolas JABBOUR, Hilary Octavia Dawn CRITCHLEY
  • Patent number: 7348023
    Abstract: Absorbent articles containing an additive are disclosed. The absorbent articles include an effective amount of an inhibitory compound, such as thiolactomycin or thiomalonate, to substantially inhibit the production of TSST-1 by Gram positive bacteria.
    Type: Grant
    Filed: October 16, 2002
    Date of Patent: March 25, 2008
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Rae Ellen Syverson, Richard A. Proctor
  • Patent number: 7344732
    Abstract: A tampon adapted to deliver a therapeutic agent, the tampon including a tampon body that is manufactured at a first manufacturing facility; and a dosage form coupled to the body, wherein the dosage form includes a formulation including a therapeutic agent, and wherein the dosage form is manufactured at a second manufacturing facility. Also, a method for producing a medicated tampon including manufacturing a tampon body at a first manufacturing facility; manufacturing a dosage form at a second manufacturing facility, wherein the dosage form includes a formulation including a therapeutic agent; and coupling the dosage form to the tampon body.
    Type: Grant
    Filed: December 31, 2002
    Date of Patent: March 18, 2008
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventor: Steven Craig Gehling
  • Patent number: 7341737
    Abstract: A tampon adapted to deliver a therapeutic agent, the tampon including a tampon body having a distal end; and a dosage form affixed to the distal end of the tampon body, wherein the dosage form includes a formulation including a therapeutic agent, and wherein the dosage form comprises a plurality of layers. Also, a method for manufacturing a medicated tampon adapted to deliver a therapeutic agent, the method including manufacturing a tampon body having a distal end; producing a dosage form having a plurality of layers, wherein the dosage form includes a formulation including a therapeutic agent; and affixing the dosage form to the distal end of the tampon body.
    Type: Grant
    Filed: December 31, 2002
    Date of Patent: March 11, 2008
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Steven Craig Gehling, Donald C. Harrison, James H. Liu, Wolfgang A. Ritschel, Chris Clendening, Giovanni M. Pauletti