Implant Or Insert Patents (Class 424/422)
  • Patent number: 10653798
    Abstract: Embodiments of the present disclosure provide for electroactive supramolecular polymeric assemblies, methods of making electroactive supramolecular polymeric assemblies, methods of using electroactive supramolecular polymeric assemblies, and the like.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: May 19, 2020
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: John Hardy, Christine E. Schmidt
  • Patent number: 10639398
    Abstract: The present disclosure provides tissue products produced from extracellular tissue matrices. The tissue products can include acellular extracellular matrices including combinations of different tissue types. The combination can harness various properties of the different tissues to provide improved composite structures with desired mechanical and/or biologic properties.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: May 5, 2020
    Assignee: LifeCell Corporation
    Inventors: Sangwook Park, Hui Xu, Aaron Barere, Israel Jessop, Mrinal Shah, Nathaniel Bachrach
  • Patent number: 10638962
    Abstract: Biocompatible implantable sensor apparatus and methods of implantation and use. In one embodiment, the sensor apparatus is an oxygen-based glucose sensor having biocompatibility features that mitigate the host tissue response. In one variant, these features include use of a non-enzymatic membrane over each of the individual analyte detectors so as to preclude contact of the surrounding tissue with the underlying enzyme or other matrix, and mitigate vascularization, and insulation of the various electrodes and associated electrolytic processes of the sensor from the surrounding tissue. In one implementation, the sensor region of the implanted apparatus is configured to interlock or imprint the surrounding tissue so as to promote a high degree of glucose molecule diffusion into the individual detectors, and a constant and predictable sensor to blood vessel interface, yet preclude the tissue from bonding to the sensor, especially over extended periods of implant.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: May 5, 2020
    Assignee: GlySens Incorporated
    Inventors: Joseph Lucisano, Timothy Routh, Joe Lin
  • Patent number: 10639163
    Abstract: Disclosed is a medical device having a first implant portion having a proximal end, a second implant portion connected to the first implant portion, the second implant portion having a distal end, and a driver assembly removably connected to the distal end, the driver assembly comprising a drill connected to the distal end at a connection.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: May 5, 2020
    Assignee: Tyber Medical, LLC
    Inventors: Jeffrey Tyber, Rui Ferreira, Christopher Faresich, Donald Buss
  • Patent number: 10629096
    Abstract: Described is a group of polymeric calcific heart valves with different levels of calcification that can be used for research and development studies related to transcatheter heart valve technologies. Using a heart flow simulator, the valves' function was studied in aortic position in the presence or absence of an implanted transcatheter aortic valve (valve-in-valve). Through multiple experiments based on echocardiography, it was found that these calcific valves can suitably mimic the function of a native calcified stenotic aortic valve and can be used for valve-in-valve studies. Using this novel polymeric calcified valve provides a desired cost-saving solution for testing the performance of new TAVR systems in vitro and in vivo.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: April 21, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Arash Kheradvar
  • Patent number: 10617744
    Abstract: Methods of treating an adult mammal for an aging-associated condition are provided. Aspects of the methods include enhancing a TIMP activity, e.g., a TIMP2 activity, in the mammal in a manner sufficient to treat the adult mammal for the aging-associated condition. Also provided are compositions for use in practicing methods of the invention. A variety of aging-associated conditions may be treated by practice of the methods, which conditions include cognitive impairments.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: April 14, 2020
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, U.S. GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Anton Wyss-Coray, Joseph M. Castellano
  • Patent number: 10617787
    Abstract: Compositions and blends of biopolymers and copolymers are described, along with their use to prepare biocompatible scaffolds and surgically implantable devices for use in supporting and facilitating the repair of soft tissue injuries.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: April 14, 2020
    Assignee: EMBODY INC.
    Inventors: Michael Francis, Nathan Kemper, Hilary Wriggers
  • Patent number: 10617788
    Abstract: The invention herein relates to the field of attaching and securing manmade material onto or into bone in correcting bone defects by implanting stress-bearing bone replacements. In particular, the invention relates to applying a coating of collagen securely onto the implant to ensure the collagen material will not be removed from the implant during installation, such as screwing the anchor into the bone. This addresses the removal of the coatings by the scraping action of the bone on the soft collagen. In the past, it has not been possible to provide adequate adhesive strength to the bone collagen/implant interface or the cohesive force of the collagen itself to prevent the removal of the coating by the abrasive action between bone and known implants.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: April 14, 2020
    Assignee: McCoy Enterprises, LLC
    Inventor: Annick F McCoy
  • Patent number: 10617513
    Abstract: A tubular patch (3) made of PGA fabric, optionally containing within it a mesh tubular support in PGA/PLA, for implantation to replace one or more urethral and/or ureteral removed segments for use in tissue reconstruction of the removed segments for the treatment of diseases such as necrosis, stenosis, tumours, trauma, iatrogenic injuries and the like, or congenital malformations.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: April 14, 2020
    Inventor: Antonio Sambusseti
  • Patent number: 10610366
    Abstract: A bone repair composition and methods thereof include bone fibers made from cortical bone in which a plurality of bone fibers are made into various implant shapes conducive to introduction into a patient through minimally invasive surgery. The bone fiber compositions may be in the form of a pellet or cylinder. A method includes producing the bone fiber graft efficiently with control of key parameters of cohesiveness, rehydration and swelling of the bone fiber graft. Another method includes introducing the bone fiber graft into the cannula efficiently. A method is also provided to allow introduction of a bone graft into a patient by placing the implant in a tube and expelling it through the action of a plunger.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: April 7, 2020
    Assignee: Theracell, Inc.
    Inventors: Andrew J. Carter, Nelson L. Scarborough, Oliver Scarborough
  • Patent number: 10610614
    Abstract: To provide a bioimplant capable of controlling a rate of an antibacterial agent and an antibiotic to be eluted from the coating film. An evanescent coating film made of a calcium phosphate-based material having crystallinity of 90% or less is formed at a predetermined area of the bioimplant and an antibacterial agent or an antibiotic is contained in the coating film. If necessary, a metal oxide layer made of a metal oxide having an isoelectric point of less than 7 is formed on the bioimplant thereby suppressing adhesion of bacteria.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: April 7, 2020
    Assignee: KYOCERA CORPORATION
    Inventors: Takao Hotokebuchi, Iwao Noda
  • Patent number: 10588946
    Abstract: The present invention relates to a peptide for promoting bone formation or inhibiting bone resorption and use thereof. The peptide for regulating bone formation or bone resorption of the present invention has the effect of promoting bone formation by enhancing osteoblast differentiation and concurrently inhibiting bone resorption by restricting osteoclast differentiation and resorptive function. Additionally, due to the low molecular weight, the peptide can be economically produced, and is thus useful for preventing and treating bone diseases.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: March 17, 2020
    Assignee: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
    Inventor: Byung Moo Min
  • Patent number: 10586734
    Abstract: A substrate processing method for forming fully self-aligned vias. The method may be performed in a batch processing system that is capable of simultaneously processing multiple substrates, where the batch processing system includes a process chamber containing processing spaces defined around an axis of rotation in the process chamber. Each of the substrates contain a first surface and a second surface, and the method includes selectively forming SiO2 raised features on the first surface relative to the second surface.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: March 10, 2020
    Assignee: Tokyo Electron Limited
    Inventor: Kandabara Tapily
  • Patent number: 10583471
    Abstract: A biosensor includes an array of metal nanorods formed on a substrate. An electropolymerized conductor is formed over tops of a portion of the nanorods to form a reservoir between the electropolymerized conductor and the substrate. The electropolymerized conductor includes pores that open and close responsively to electrical signals applied to the nanorods. A dispensing material is loaded in the reservoir to be dispersed in accordance with open pores.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: March 10, 2020
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Steven J. Holmes, Emily R. Kinser, Qinghuang Lin, Nathan P. Marchack, Roy R. Yu
  • Patent number: 10576104
    Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: March 3, 2020
    Assignee: Osiris Therapeutics, Inc.
    Inventors: Samson Tom, Alla Danilkovitch, Dana Yoo, Timothy Jansen, Jin-Qiang Kuang, Jennifer Michelle Marconi
  • Patent number: 10580592
    Abstract: Provided is a method for manufacturing an electrode material having a pressing step in which an irregularly shaped aggregate containing at least an active material is statically pressed in the presence of an alkali metal source and a solvent.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: March 3, 2020
    Assignee: JSR Corporation
    Inventors: Koji Sumiya, Shigehito Asano, Yasuyuki Koga, Ryo Kimura, Tsutomu Reiba, Terukazu Kokubo, Nobuo Ando
  • Patent number: 10573409
    Abstract: A system and method for automatically calculating an accurate recommended dosage for hormone replacement therapy and automating the life cycle of a patient's treatment over time. The system and method can automatically acquire relevant patient parameters and apply a consistent formulaic approach to help reduce incorrect dosage determinations. A pellet insertion size may be determined and documented based on a calculated dosage, and an insertion side and lot numbers may be tracked and managed. In addition, corresponding revenues may be tracked and profitability may be reported for hormone replacement therapy practices.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: February 25, 2020
    Assignee: The SottoPelle Group, LLP
    Inventor: Gino Tutera
  • Patent number: 10556995
    Abstract: A process of making compositions comprising benefit agent delivery particles comprises the steps of combining a graft co-polymer and a benefit agent to form a premix composition, and combining the premix composition and water and/or consumer product adjunct material to form the compositions. The resulting compositions comprise benefit agent delivery particles that comprise the graft co-polymer and benefit agent.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: February 11, 2020
    Assignee: The Procter & Gamble Company
    Inventors: Yousef Georges Aouad, Johan Smets, Luke Andrew Zannoni, Piero Baglioni, Paolo Tempesti, Arianna Bartolini
  • Patent number: 10543294
    Abstract: A bone graft composition includes a biologically-resorbable cement and a plurality of processed bone particles, where each of the bone particles have a shape configured to interconnect with adjacent bone particles. A method for treating a bone defect using the bone graft compositions includes providing the bone graft composition and administering an effective amount of the bone graft composition to a site of a bone defect in a subject. Kits including a biologically-resorbable cement powder and a plurality of processed bone particles are also provided.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: January 28, 2020
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Michael J. Voor, Robert L. Burden, Jr.
  • Patent number: 10543249
    Abstract: A pharmaceutical composition for a sustained release of peptide therapeutics, in particular for a sustained release compatible with therapeutic treatments of at least two months. In an embodiment, the composition comprises lanreotide as an active agent, a hydrosoluble co-solvent, and water with the pH of the composition being from 4.0 to 7.5.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: January 28, 2020
    Assignee: IPSEN PHARMA S.A.S.
    Inventors: Ruth Bielsa Guivernau, Roland Cherif-Cheikh, Julie Fournes, Daniel Martinez Lorente, Anne Petit, Joël Richard
  • Patent number: 10538631
    Abstract: The present invention relates to benefit agent containing delivery particles, compositions comprising said particles, and processes for making and using the aforementioned particles and compositions. When employed in compositions, for example, cleaning or fabric care compositions, such particles increase the efficiency of benefit agent delivery, thereby allowing reduced amounts of benefit agents to be employed. In addition to allowing the amount of benefit agent to be reduced, such particles allow a broad range of benefit agents to be employed.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: January 21, 2020
    Assignee: The Procter & Gamble Company
    Inventors: Yousef Georges Aouad, Johan Smets, Luke Andrew Zannoni, Piero Baglioni, Paolo Tempesti, Arianna Bartolini
  • Patent number: 10537664
    Abstract: The invention relates to a cell sheet construct for neurovascular reconstruction. The cell sheet construct has a vascular endothelial cell layer and a neural stem cell layer, and the two layers are physically in direct contact with each other, where the vascular endothelial cell layer forms branching vasculatures, and the neural stem cell layer differentiates into neurons. The invention also relates to a method for manufacturing the cell sheet construct, having the following steps: culturing vascular endothelial cells on a substrate to form a vascular endothelial cell layer, seeding neural stem cells on the vascular endothelial cell layer to make the neural stem cells be physically in direct contact with the vascular endothelial cell layer, and culturing the neural stem cells and the vascular endothelial cell layer to differentiate into neurons and branching vasculatures to form a cell sheet construct.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: January 21, 2020
    Assignee: NATIONAL DEFENSE MEDICAL CENTER
    Inventors: Chung-Hsing Chou, Dueng-Yuan Hueng, Tsung-Neng Tsai
  • Patent number: 10507254
    Abstract: A biocompatible curable composition and a method of detecting a border of a tumor, a tissue of interest, or both including injecting the biocompatible curable composition and contacting the border of a tumor or a tissue, the biocompatible curable composition crosslinks to form a three-dimensional cured nanocomposite, and imaging the three-dimensional (3D) cured nanocomposite, and imaging the 3D cured nanocomposite by at least one of MRI, CT, ultrasound, and X-ray, to detect the border of the tumor or the tissue of interest or track tumor motion during radiotherapy treatment. The biocompatible curable composition comprising an organic polymer having a hydrolysable functional group, a metallic nanoparticle, and a polar or a non-polar solvent. A brachytherapy strand consisting of a biocompatible curable composition and a radio-isotope seed. The biocompatible curable composition is shaped into an elongated cylinder and forms a 3D cured nanocomposite with a radio-isotope seed embedded.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: December 17, 2019
    Assignees: National Guard Health Affairs, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center
    Inventor: Mamdooh Alqathami
  • Patent number: 10485894
    Abstract: A formed sheet product of a polymer composition comprising at least one protein selected from the group consisting of fibrinogen and thrombin and at least one polymer selected from the group consisting of an aliphatic polyester and a water-soluble polymer, and a laminated formed sheet product comprising a first polymer composition layer composed of fibrinogen and a water-soluble polymer and a second polymer composition layer composed of thrombin and an aliphatic polyester are provided. These formed products are applied onto a wound site and function as a hemostatic material.
    Type: Grant
    Filed: May 13, 2013
    Date of Patent: November 26, 2019
    Assignees: TEIJIN LIMITED, Teijin Pharma Limited, KM BIOLOGICS CO., LTD.
    Inventors: Yukako Kageyama, Kentaro Fujinaga, Ayuko Yamaguchi, Yusuke Akiyama, Akitoshi Oono, Susumu Honda, Makoto Satake, Hiroaki Kaneko, Takayuki Imamura, Ryoichi Kawamura, Masaki Hirashima
  • Patent number: 10487824
    Abstract: The method of making a hydrolyzed collagen gel is a manufacturing method for producing a hydrolyzed collagen gel to be used as a topical wound treatment. A first volume of purified water is initially heated to a temperature ranging from about 71° C. to about 77° C., and a hydrolyzed type I collagen powder is then mixed into the heated purified water to form a first mixture. An additive is mixed into the first mixture to form a second mixture, where the additive may be native collagen, at least one amino acid, least one therapeutic agent, gelatin, whey, hydrolyzed whey, polysulfated glycosaminoglycan, a glucosamine salt, glutamine, glycosaminoclycans, zinc, silver oxide alginates, cellulose, honey, mushroom extract and combinations thereof. A second volume of purified water is then added to the second mixture to form the hydrolyzed collagen gel product. Mixing is performed as a continuous, recirculating, temperature-monitored and temperature-maintained process.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: November 26, 2019
    Inventor: George D. Petito
  • Patent number: 10478309
    Abstract: A semi-synthetic hybrid material having a pH from 7 to 7.4 includes an inorganic fraction and a cross-linked organic fraction. The method for producing this material, and osteosynthesis devices or implants made of semi-synthetic hybrid material are also described.
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: November 19, 2019
    Assignee: MBP (MAURITIUS) LTD
    Inventors: Georges Camprasse, Serge Camprasse
  • Patent number: 10470890
    Abstract: A medical grade thermoplastic or polymer implant with an osteoconductive coating is provided, specifically for corrections of the distal and proximal interphalangeal toe joints of the foot. The implant can be either straight or angled, and can be either solid or cannulated for insertion. The implant is sized and shaped depending on the specific anatomy and desired correction. End portions of the implant may be coated with an osteoconductive coating that promotes bone growth, but may reduce radiolucency. Thus, a central portion of the implant may remain uncoated to increase radiolucency of the implant at the region where two bones come together.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: November 12, 2019
    Assignee: Neutin Orthopedics, LLC
    Inventors: Albert Eugene Austin, Steven Keith Neufeld, Adam D. McQueen, Simon J. Mest, Paul S. Cooper
  • Patent number: 10463673
    Abstract: The present invention is directed to nanoparticulate compositions comprising meloxicam particles having an effective average particle size of less than about 2000 nm.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: November 5, 2019
    Assignee: Recro Pharma, Inc.
    Inventors: Eugene R. Cooper, Tuula Ryde, John Pruitt, Laura Kline
  • Patent number: 10463469
    Abstract: The present invention aims to provide a method for producing a porous tissue regeneration substrate that allows a wide choice of solvents and easy adjustment of the bulk density and pore size of the porous substrate. The present invention also aims to provide a method for producing an artificial blood vessel and an artificial blood vessel. The present invention relates a porous, tubular artificial blood vessel containing a bioabsorbable material, the artificial blood vessel including: a skin layer having a relatively small pore size as an innermost layer; and a porous layer positioned around the skin layer and having a relatively large pore size.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: November 5, 2019
    Assignee: GUNZE LIMITED
    Inventors: Hidetaka Nakayama, Kosuke Sawai, Toshiharu Shinoka, Shuhei Tara, Hirotsugu Kurobe
  • Patent number: 10463407
    Abstract: An implant that facilitates the fusion of a first bone part with a second bone part includes an implant body that extends between the first bone part and the second bone part. The implant body includes a first portion that fits within a first receiving aperture in the first bone part, and the implant body includes a second portion that fits within a second receiving aperture in the second bone part. At least one of the first portion and the second portion can be made of bone. Additionally, at least the second portion is formed to have a non-circular cross-sectional shape to inhibit relative motion between the bone parts and the implant body.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: November 5, 2019
    Assignee: WRIGHT MEDICAL TECHNOLOGY, INC.
    Inventors: Alan G. Taylor, Rebecca Hawkins Wahl, Bruce R. Lawrence
  • Patent number: 10463366
    Abstract: Adjunct materials for delivery to liver tissue are provided. In general, the adjunct materials can be configured to be delivered to tissue by deployment of staples from a cartridge body of a surgical stapler. The adjunct material is configured to transition from an unexpanded configuration to an expanded configuration after delivery thereof to the liver tissue. The adjunct material can include an effective amount of one or more medicants, such as a hemostatic agent or a tissue healing agent, disposed within and releasable from the adjunct material for delivery to the liver tissue. The adjunct material can expand to apply pressure to liver tissue to facilitate sealing of one or more fractures in the stapled liver tissue. Methods of using a staple cartridge assembly or an end effector to apply such adjunct materials to liver tissue are also provided.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: November 5, 2019
    Assignee: Ethicon LLC
    Inventors: Michael J. Vendely, Jason L. Harris, Frederick E. Shelton, IV, Charles J. Scheib
  • Patent number: 10449272
    Abstract: The present disclosure provides a hydrogel composition including: a hydrogel having a structure represented by Formula (I) or Formula (II) shown as follows: A-B-BOX-B-A, Formula (I); B-A-B-(BOX-BAB)n-BOX-B-A-B, Formula (II), wherein, A is a hydrophilic polyethylene glycol polymer, B is a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2,2?-Bis(2-oxazoline) for coupling di-block of A-B or tri-block of B-A-B, and n is an integer greater than or equal to 0; and an anti-adhesion additive, wherein the anti-adhesion additive comprises a carbohydrate, a nitrogen-containing cyclic compound, a polymer or a combination thereof.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: October 22, 2019
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Yu-Chi Wang, Hsin-Hsin Shen, Chin-Fu Chen, Meng-Yow Hsieh, Sen-Lu Chen, Yu-Bing Liou, Tsai-Yu Lin, Pei-Shan Li, Wei-Lin Yu
  • Patent number: 10441664
    Abstract: The disclosure describes collagen constructs comprising antimicrobial agents and related methods.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: October 15, 2019
    Assignee: MiMedx Group, Inc.
    Inventor: Thomas J. Koob
  • Patent number: 10428130
    Abstract: The present invention relates to a method for purifying a protein belonging to the transforming growth factor-? (TGF-?) superfamily, said method comprising subjecting a cell culture medium containing the protein to a Hydrophobic Charge 5 Interaction Chromatography (HCIC).
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: October 1, 2019
    Assignee: ISTITUTO BIOCHIMICO ITALIANO GIOVANNI LORENZINI S.P.A.
    Inventors: Fabio Centola, Leonardo Sibilio
  • Patent number: 10413416
    Abstract: Method and set of surgical instruments for fitting a shoulder prosthesis, and the shoulder prosthesis. The proposed method seeks to interpose a bone graft between the previously prepared glenoid surface (G) of a scapula (S) of a patient's shoulder and the face of a glenoid prosthetic component opposite the articular surface. The set of instruments permit the bone graft to be taken from the upper epiphysis of the humerus (H), either in situ or ex vivo.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: September 17, 2019
    Assignee: Tornier SAS
    Inventors: Pascal Boileau, Gilles Walch
  • Patent number: 10391090
    Abstract: Disclosed herein are methods for treating solid tumors by direct injection into the tumors of chemotherapeutic particles, methods for inhibiting tumor metastasis by administering chemotherapeutic particles to a subject having a tumor, and compositions that include chemotherapeutic particles, small, amounts of a polysorbate, and a carrier.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: August 27, 2019
    Assignee: Crititech, Inc.
    Inventors: Mike Baltezor, Gere diZerega, Charles Decedue, Sam Campbell, Matt McClorey
  • Patent number: 10391288
    Abstract: A device for sustained delivery of a poorly water soluble drug is described. A drug reservoir within the device, when in operation, contains an aqueous suspension of the drug mixed with a suspension of an excipient that, in one embodiment, generates acidic groups for a sustained period of time to maintain a desired pH in the aqueous suspension that in turn provides a constant concentration of a soluble form of the drug.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: August 27, 2019
    Assignee: Delpor, Inc.
    Inventors: Francis J. Martin, Ling-Ling Kang
  • Patent number: 10383882
    Abstract: This invention relates a controlled release delivery composition for an otorhinolaryngology and otorhinolaryngology-associated pathology, conditions, indications or their combination, Head and Neck associated pathology conditions, indications or their combination, or their combination, using a chitosan-glycerophosphate (CGP) hydrogel and an agent or a bio-materials. Additionally, provided methods of treating an otorhinolaryngology and otorhinolaryngology-associated pathology, conditions, indications or their combination, Head and Neck associated pathology conditions, indications or their combination, or their combination.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: August 20, 2019
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Bert W. O'Malley, Daqing Li, David Paulson
  • Patent number: 10383905
    Abstract: The present invention relates to an extract of Cynara spp. and also to compositions and kits that comprise said extract for the prevention and/or the treatment of a pathological condition characterized by a constitutive activation of the STAT3 transcription factor.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: August 20, 2019
    Assignee: ABOCA S.P.A. SOCIETA' AGRICOLA
    Inventor: Valentino Mercati
  • Patent number: 10369253
    Abstract: In one aspect, there is provided a method for preparing a biocompatible coated substrate. The method generally includes: depositing nucleation amorphous calcium phosphate sites on at least a portion of an outer surface of a substrate by: exposing at least the portion of the outer surface to a mixture having a favorable Ca/P molar ratio, and irradiating with microwave energy; and, stabilizing the deposited nucleation amorphous calcium phosphate sites on the portion of the outer surface. In another aspect, there is provided herein a method for preparing a biocompatible coated substrate.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: August 6, 2019
    Assignee: The University of Toledo
    Inventors: Sarit B. Bhaduri, Vijay K. Goel, Huan Zhou
  • Patent number: 10369539
    Abstract: The present invention broadly relates to a process for preparing products comprising active components, and in particular biological materials, wherein the active components are stabilised. The invention further relates to compositions comprising the products, and in particular compositions comprising therapeutic biological materials.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: August 6, 2019
    Assignee: BIOLINGUS IP LLC
    Inventor: Sai Ying Ko
  • Patent number: 10363017
    Abstract: A method for determining and graphically marking a position within a lumen of the body of a patient indicative of occlusion includes providing a user interface, using a processor, configured to allow a user to select an occlusion percentage threshold, determining, using the processor, a percentage of occlusion in the lumen, comparing, using the processor, the determined percentage of occlusion with the selected occlusion percentage threshold and identifying a region of the lumen that is occluded more than the selected occlusion percentage threshold, and designating, using the processor, the identified region on an image of the lumen with at least one mark.
    Type: Grant
    Filed: December 10, 2012
    Date of Patent: July 30, 2019
    Assignee: St. Jude Medical International Holding S.à r.l.
    Inventor: Gera Strommer
  • Patent number: 10363312
    Abstract: Disclosed herein are compositions comprising an NSAID such as meloxicam in combination with a cyclodextrin and/or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of conditions such as pain.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: July 30, 2019
    Assignee: AXSOME THERAPEUTICS, INC.
    Inventor: Herriot Tabuteau
  • Patent number: 10358516
    Abstract: The present invention discloses a freezing-illumination method for preparing porous gels, comprising the steps of: (a) synthesizing the gels containing dynamic exchangeable bonds; (b) illuminating the gels under frozen state by certain wavelength light source; (c) elevating the temperature and melt the ice crystals within the gels to get the porous structure. The dynamic exchangeable bonds existing in the gels include double/multi-sulfur bond, hydrazine bond, boronic ester bond. Catalyst is also included in the gel composition to activate the bond exchange reactions under illumination. This new method for preparing porous gels is easy to operate and suitable for most kinds of gels. Meanwhile, it can spatially control the pore structure within the gels by local illumination.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: July 23, 2019
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Qian Zhao, Jingjun Wu, Tao Xie, Di Chen
  • Patent number: 10357593
    Abstract: A malleable demineralized bone composition consists of cortical bone made from a first portion and a second portion. The first portion of cortical bone is made from cut pieces freeze dried then ground into particles and demineralized then freeze-dried. The second portion of cortical bone is shaved into shavings. The shavings are long thin strips subjected to freeze-drying. The freeze-dried shavings are ground and demineralized and then freeze-dried. A volume of the second portion is placed in a solution of sterile water to create a mixture, the water volume being twice the second portion, the mixture is autoclaved under heat and pressure to form a gelatin, and the first portion is mixed with the gelatin to form a malleable putty or paste.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: July 23, 2019
    Assignee: Vivex Biomedical, Inc.
    Inventors: Edgar S. Maldonado, Silvia Daniela Gonzales
  • Patent number: 10350159
    Abstract: An injectable intramuscular depot composition suitable for forming an in situ solid implant in a body, comprising a drug which is paliperidone and/or its pharmaceutical acceptable salts in any combination thereof, a biocompatible copolymer based on lactic and glycolic acid having a monomer ratio of lactic to glycolic acid of about 50:50 and DMSO as solvent, wherein the composition releases the drug with an immediate onset of action and continuously for at least 8 weeks and wherein the composition has a pharmacokinetic profile in vivo suitable for the formulation to be administered each 8 weeks or even longer periods.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: July 16, 2019
    Assignee: Laboratories Farmacéuticos Rovi, S.A.
    Inventors: Ibon Gutierro Aduriz, Guillermo Franco Rodríguez
  • Patent number: 10350237
    Abstract: A biocompatible, electrically conductive biomaterial capable of earn carrying the electrical potential of a cardiac impulse and comprising (1) a conductive polymer such as polyaniline, polypyrrole or polythiophene, and (ii) a biocompatible component such as a polysaccharide, a protein, or a polypeptide, in particular chitosan or gelatin, is described. The material can take the form of a hydrogel, membrane, sheet or mesh. It can be used to restore or improve electrical impulse propagation across damaged tissue or scar region of the myocardium, in particular in the ti treatment of myocardial infarction and arrhythmia.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: July 16, 2019
    Assignee: University Health Network
    Inventor: Ren-Ke Li
  • Patent number: 10352924
    Abstract: Nanofibrous hydrogel microarray systems that act as facile, high throughput platforms for in vitro drug discovery and investigation and screening of combinatorial effects of physical and biochemical cues on maturation and differentiation of mammalian cells.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: July 16, 2019
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Michael Floren, Wei Tan, Sadhana Sharma, Stephanie Bryant
  • Patent number: 10347434
    Abstract: A nanowire energy storage device such as a nanowire battery or a capacitor having a cathode comprising a plurality of nanowires and an anode comprising a plurality of nanowires interlaced with the plurality of nanowires of the cathode, and embedded in a PMMA gel electrolyte.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: July 9, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Reginald M. Penner, Mya Le Thai
  • Patent number: 10335366
    Abstract: The present invention is directed to an injectable intramuscular depot composition suitable for forming an in situ solid implant in a body, comprising a drug which is risperidone and/or paliperidone or any pharmaceutically acceptable salt thereof in any combination, a biocompatible copolymer based on lactic and glycolic acid having a monomer ratio of lactic to glycolic acid of about 50:50 and a DMSO solvent, wherein the composition releases the drug with an immediate onset of action and continuously for at least 4 weeks and wherein the composition has a pharmacokinetic profile in vivo that makes it suitable to be administered each 4 weeks or even longer periods.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: July 2, 2019
    Assignee: Laboratorios Farmacéuticos Rovi, S.A.
    Inventors: Ibon Gutierro Aduriz, Guillermo Franco Rodríguez