Effervescent Or Pressurized Fluid Containing Patents (Class 424/43)
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Publication number: 20120020895Abstract: A bear bile macromolecular extract with anti-HCV virus function is disclosed. A preparation method comprises the following steps of: taking fresh bear bile or dissolving bear bile powder with water, centrifuging it by a molecular sieve filter membrane with molecular weight cut-off of 100,000 or an ultrafiltration membrane, filtering to obtain sediment, dissolving the sediment with water, adding the solution to sephadex column, separating the solution by using water or buffer as elution solvent, and freeze-drying the eluent to obtain the bear bile macromolecular extract. Experiments show that the bear bile macromolecular extract has anti-HCV virus function and can be used for treating hepatitis C.Type: ApplicationFiled: December 10, 2009Publication date: January 26, 2012Applicant: HEILONGJIANG GAP (GOOD AGRICULTURE PRACTICE) RESEARCH CENTERInventors: Xijun Wang, Xiuhong Wu, Hui Sun, Wenjun Sun
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Publication number: 20120009127Abstract: A personal care cleansing composition is provided which includes a C10-C24 acyl glycinate salt and a dihydroxypropyl quaternary ammonium salt. Most preferred is sodium cocoyl glycinate in combination with dihydroxypropyl trimethyl ammonium chloride. The quaternary ammonium salt enhances foaming properties of the glycinate salt.Type: ApplicationFiled: July 12, 2010Publication date: January 12, 2012Applicant: CONOPCO, INC., D/B/A UNILEVERInventors: Bivash Ranjan Dasgupta, Prabhjyot Singh, Kavssery Parameswaran Ananthapadmanabhan, Prem Chandar
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Publication number: 20120009128Abstract: A preservative system and a personal care composition containing that system is provided which includes the preservative combination of a C10-C24 acyl glycinate salt and a hydroxyethyl sulfonate salt. This preservative system is effective against gram negative bacteria, particularly Pseudomonas aeruginosa.Type: ApplicationFiled: July 12, 2010Publication date: January 12, 2012Applicant: CONOPCO, INC., D/B/A UNILEVERInventors: Roberta Marie Betkoski, Deidre Lee Mitchell, Kavssery Parameswaran Ananthapadmanabhan, Lin Yang
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Publication number: 20120009129Abstract: Pharmaceutical compositions to deter misuse, abuse and diversion of pharmaceutical dosage units containing drugs susceptible to abuse with generation of high volume foam upon contact with a suitable media.Type: ApplicationFiled: December 23, 2010Publication date: January 12, 2012Applicant: ACURA PHARMACEUTICALS, INC.Inventor: Albert Walter BRZECZKO
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Publication number: 20120009130Abstract: The present disclosure provides compositions and methods of enhancing resistance to viral infections through targeted delivery of 5?PPP negative stranded siRNA via nanoparticles, specifically gold nanorods. The 5?PPP activates type I interferon through the signaling cascade providing a novel therapeutic and prophylactic for seasonal and pandemic influenza. The technology described herein also extends the findings to the use of nanoparticles for delivery of genetic material including but not limited to siRNA and microRNA to accomplish targeted nanoparticle based gene therapy.Type: ApplicationFiled: May 6, 2011Publication date: January 12, 2012Applicant: NANOAXISInventors: Krishnan Chakravarthy, Suryaprakash Sambhara, Paul Knight
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Publication number: 20110318412Abstract: The invention disclosed herein generally relates to low-dose oral doxepin pharmaceutical formulations and the use of these formulations to promote sleep.Type: ApplicationFiled: May 18, 2007Publication date: December 29, 2011Applicant: Somaxon Pharmaceuticals, Inc.Inventors: Luigi Schioppi, Brian T. Dorsey, Michael Skinner, John Carter, Terry Cobb, Neil B. Kavey
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Publication number: 20110311458Abstract: The present invention relates to alkaloid aminoester compounds which act as muscarinic receptor antagonists, processes for their preparation, compositions comprising them, and therapeutic uses thereof.Type: ApplicationFiled: June 22, 2011Publication date: December 22, 2011Applicant: Chiesi Farmaceutici S.p.A.Inventors: Gabriele AMARI, Mauro Riccaboni, Stefano Bossolo
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Publication number: 20110311459Abstract: The present invention relates to alkaloid aminoester compounds which act as muscarinic receptor antagonists, processes for the preparation of such a compound, compositions which contain such a compound, and therapeutic uses of such a compound.Type: ApplicationFiled: June 22, 2011Publication date: December 22, 2011Applicant: Chiesi Farmaceutici S.p.A.Inventors: Gabriele AMARI, Mauro RICCABONI
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Publication number: 20110305735Abstract: A method for skin antiaging treatment comprising administering Botulinum toxin to an area of facial and/or neck skin, combined with the administration of a cosmetic or pharmaceutical composition comprising a cosmetically or pharmaceutically effective amount of at least one peptide derived from the SNAP-25 protein and/or at least one enkephalin-derived peptide, and at least one cosmetically or pharmaceutically acceptable excipient or adjuvant.Type: ApplicationFiled: June 9, 2010Publication date: December 15, 2011Inventors: Juan CEBRIAN PUCHE, Nuria ALMIÑANA DOMENECH, Raquel DELGADO GONZALEZ
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Publication number: 20110305643Abstract: Described herein are high oil-content emulsions and compositions for the treatment of inflammatory skin disorders. The emulsions may be formulated as aerosol compositions. The aerosol propellant may be a hydrofluoroalkane propellant. The emulsions or compositions may comprise active agents, such as corticosteroids. Also described are methods of treating inflammatory skin disorders, comprising the step of applying to an affected area of a subject in need thereof a therapeutically-effective amount of an inventive emulsion or aerosol composition.Type: ApplicationFiled: March 11, 2011Publication date: December 15, 2011Applicant: Precision Dermatology, Inc.Inventors: Ronald M. Gurge, Mark W. Trumbore, Lisa Chin, Poonam S. Hirani
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Publication number: 20110300199Abstract: Peptides of general formula (I): R1-Wp-Xn-AA1-AA2-AA3-AA4-Ym-R2 their stereoisomers, mixtures thereof, and/or their cosmetically or pharmaceutically acceptable salts, a method of preparation, cosmetic or pharmaceutical compositions containing them and their use for the treatment, prevention and/or care of conditions, disorders and/or diseases of the skin, mucous membranes and/or scalp.Type: ApplicationFiled: February 16, 2010Publication date: December 8, 2011Applicant: LIPOTEC, S.A.Inventors: Nuria Garcia Sanz, Wim Van Den Nest, Cristina Carreno Serraima, Antonio Ferrer Montiel, Juan Cebrian Puche, Nuria Alminana Domenech
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Publication number: 20110300081Abstract: The present invention refers to pharmaceutical, dietary and/or nutraceutical orosoluble and/or effervescent compositions for oral use containing at least a salt of S-adenosyl methionine (SAMe), combined with physiologically acceptable excipients and optionally additional active ingredients. In particular the invention refers to compositions with high palatability formulated in tablet, capsule or granules. The present invention also refers to the use of at least a salt of SAMe combined with physiologically acceptable excipients and optionally further active ingredients for treating, human or veterinarian, neuropsychiatric, osteoarticular or hepatic diseases.Type: ApplicationFiled: January 11, 2010Publication date: December 8, 2011Applicant: GRAAL SRLInventor: Alessandro Seneci
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Patent number: 8071127Abstract: Methods for formulating immediate and sustained release anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.Type: GrantFiled: October 30, 2008Date of Patent: December 6, 2011Assignee: Aradigm CorporationInventors: David C. Cipolla, James Blanchard
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Publication number: 20110293533Abstract: Disclosed are mixtures and compositions for controlling invertebrate pests relating to combinations comprising (a) 3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide, and its N-oxides, and suitable salts thereof and a component (b) wherein the component (b) is at least one compound or agent selected from neonicotinoids, cholinesterase inhibitors, sodium channel modulators, chitin synthesis inhibitors, ecdysone agonists, lipid biosynthesis inhibitors, macrocyclic lactones, GABA-regulated chloride channel blockers, juvenile hormone mimics, ryanodine receptor ligands, octopamine receptor ligands, mitochondrial electron transport inhibitors, nereistoxin analogs, pyridalyl, flonicamid, pymetrozine, dieldrin, metaflumizone, biological agents, and suitable salts of the foregoing.Type: ApplicationFiled: August 11, 2011Publication date: December 1, 2011Applicant: E.I. DU PONT NEMOURS AND COMPANYInventors: Isaac Billy Annan, John Lindsey Flexner, Hector Eduardo Portillo, George Philip Lahm, Thomas Paul Selby, Thomas Martin Stevenson
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Publication number: 20110293680Abstract: The present invention relates to a composition of a temporary hair thickener. In particular, the present invention relates to a composition of a temporary hair thickener comprising bamboo charcoal powder, a hydrophobic waterproof coating agent, a low grade alcohol and a propellant in a specific amount. The composition of a temporary hair thickener in accordance with the present invention can be attached to hair for a longer time as compared with the prior art hair thickeners, thereby showing improved persistency. Further, since the thickener ingredients of the composition are hardly flowed down or detached from hairs by rain or sweat, the composition of the present invention solves the problem of blotting the skin and clothes.Type: ApplicationFiled: July 20, 2009Publication date: December 1, 2011Applicant: DONG SUNG PHARM. CO., LTD.Inventors: Bong-Lim Jo, Hye-Jin Moon
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Publication number: 20110293532Abstract: An antiperspirant composition may include an aqueous carrier; and at least 4 to 7 weight percent of an aluminum and/or aluminum-zirconium antiperspirant active containing at least a Peak 4 specie. An antiperspirant composition may also include an aqueous carrier; and an aluminum and/or aluminum-zirconium antiperspirant active containing at least a Peak 4 specie, wherein the antiperspirant active contains less than 3 area percent Peak 1 and/or Peak 2 species from an HPLC chromatograph of the antiperspirant composition.Type: ApplicationFiled: May 24, 2011Publication date: December 1, 2011Applicant: COTY INC.Inventors: Tamara Babenko, Thomas Schamper
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Publication number: 20110287072Abstract: The invention provides methods and pharmaceutical compositions for treating symptoms associated with lactose intolerance and for overall improvement in gastrointestinal health. Described herein are methods and pharmaceutical compositions for improving overall gastrointestinal health or for decreasing symptoms of lactose intolerance by administering to subject in need thereof a pharmaceutical composition comprising a prebiotic, optionally in combination with effective amount of a probiotic microbe or microbes.Type: ApplicationFiled: August 4, 2011Publication date: November 24, 2011Applicant: Ritter Pharmaceuticals, Inc.Inventors: Andrew J. Ritter, Dennis Savaiano, David Barnes, Todd Klaenhammer
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Publication number: 20110274627Abstract: A process of making an aerosol shave composition, preferably a post foaming shave gel, comprising a hydrophobic agent, such as a silicon, in the form of a microdroplet having a particle size from about 0.15 microns to about 10 microns.Type: ApplicationFiled: May 4, 2011Publication date: November 10, 2011Inventors: Ali Abdelaziz Alwattari, Marcia J. Holden, George Endel Deckner
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Publication number: 20110268664Abstract: The invention relates to an effervescent composition for adding to the drinking water of an animal. The composition comprises an effervescent agent and a palatant. The composition may be used in hydration treatment of an animal, as an additive for animal drinking water and for delivering a micronutrient or functional ingredient. Animals are encouraged to drink more drinking water by the effervescent composition.Type: ApplicationFiled: June 16, 2008Publication date: November 3, 2011Applicant: Hills Pet Nutrition, IncInventors: Sarah Martinez, Pavinee Chinachoti, Douglas Nadeau, Shawn Taylor
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Publication number: 20110268667Abstract: A freshening composition having a malodor control component, about 1% to about 5% of low molecular weight monohydric alcohols, and an aqueous carrier are provided. The composition is essentially free of any material that would soil or stain fabric. The composition may be delivered to fabrics and/or air. The malodor control component may include an effective amount of volatile aldehydes and/or an acid catalyst.Type: ApplicationFiled: April 7, 2011Publication date: November 3, 2011Inventors: Ricky Ah-Man WOO, Steven Anthony Horenziak, Rhonda Jean Jackson, Zaiyou Liu, Michael-Vincent Nario Malanyaon, Jason John Olchovy, Christine Marie Readnour
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Publication number: 20110268665Abstract: A waterless foamable carrier and pharmaceutical composition which is suitable for external and internal administration is disclosed. The composition is single phase and includes at least one liquid oil; and a glyceride. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.Type: ApplicationFiled: October 6, 2009Publication date: November 3, 2011Inventors: Dov Tamarkin, David Schuz, Yohan Hazot, Elana Gazal
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Publication number: 20110262369Abstract: The invention relates to a crystalline, enantiomerically pure hydrochloride salt of N-(5-{2-[3-(4,4-diethyl-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-phenyl)-methane sulfonamide, preferably N-(5-{(R)-2-[3-(4,4-diethyl-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-phenyl)-methane sulfonamide, and the effect thereof as a long-term betamimetic agent, alone or combined with at least one other active ingredient, in the treatment of respiratory diseases.Type: ApplicationFiled: February 17, 2009Publication date: October 27, 2011Inventors: Ulrike Werthmann, Marco Santagostino, Adil Duran
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Publication number: 20110262498Abstract: Provided herein are methods of preventing, lessening or treating pulmonary fibrosis in a subject. The methods comprise delivering an amount of a powdered extracellular matrix (ECM)-derived material to the respiratory system of the subject effective to prevent, lessen or treat pulmonary fibrosis in a subject. Also provided is an apparatus for delivering the powdered ECM-derived material to a subject.Type: ApplicationFiled: December 4, 2009Publication date: October 27, 2011Applicant: University of Pittsburgh-Of the Commonwealth System of Higher EducationInventors: Thomas Gilbert, Michelle Manni, Tim D. Oury
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Publication number: 20110262368Abstract: The present invention provides compounds of Formula (VII) and 11-keto analogs thereof, and pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers, and isomers of said compounds and said 11-keto analogs, having the general structure formula (VII): wherein L, R1, R2, R3, R4, and R5 are selected independently of each other and as defined herein. Also provided are pharmaceutical compositions, methods of preparing, and methods of using such compounds in the treatment and prophylaxis of a wide range of immune, autoimmune, and inflammatory diseases and conditions. The novel compounds of the present invention possess useful pharmacological activity while having unexpectedly low systemic activity. Thus, the compounds of the invention represent a safer alternative to those known glucocorticoids which have poor side-effect profiles.Type: ApplicationFiled: December 18, 2008Publication date: October 27, 2011Applicant: Schering CorporationInventors: John C. Anthes, Kevin D. McCormick, John A. Hey, Robert G. Aslanian, Purakkattle J. Biju, Michael Y. Berlin, Daniel M. Solomon, Philippa H. Solomon, Hongwu Yang, Yeon-Hee Lim, Yoon Joo Lee, Rema Danielle Bitar
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Publication number: 20110256070Abstract: The present invention provides pharmaceutical compositions and methods for dispensing the same using an aerosol whereby the composition takes the form of foam. Additionally, the present invention provides a barrier system including a concentrate separated from a non-chlorine aerosol propellant wherein the concentrate includes a non-aqueous solvent, an emulsifying agent, a thickening agent, at least one medicament and optionally an aqueous solvent.Type: ApplicationFiled: April 18, 2011Publication date: October 20, 2011Applicant: GELMED, LLCInventors: James H. Martin, Christopher J. Sciarra, John J. Sciarra
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Publication number: 20110250149Abstract: The present invention provides tiotropium bromide having a low degree of crystallinity. The present invention also provides a complex of tiotropium bromide and polyvinylpyrrolidone, processes for preparing it and pharmaceutical formulations including it.Type: ApplicationFiled: October 29, 2009Publication date: October 13, 2011Applicant: CIPLA LIMITEDInventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Maruti Ghagare
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Publication number: 20110250148Abstract: Inventive subject matter described herein includes a powder comprising: a wax having a melt point within a range of 45 to 100 degrees Centigrade and sodium polyacrylate or salts of sodium polyacrylate or sodium polyacrylate and salts of sodium polyacrylate wherein the wax concentration falls within a range of 99.9% to 0.1% by weight and the sodium polyacrylate concentration falls within a range of 0.1% to 99.9% by weight, wherein the powder is effective for forming a cream or lotion or gel or coating when mixed with water at room temperature or cooler than room temperature.Type: ApplicationFiled: July 26, 2010Publication date: October 13, 2011Applicant: Jeen InternationalInventors: Juan R. Mateu, Adam Perle
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Publication number: 20110250147Abstract: A film forming material can be used for the preparation of a medicament for pre-treating an area of skin to reduce causes of skin irritation, resulting in a educed risk of acquiring skin chafing and/or blisters. A method of pre-treating can comprise the steps of: providing a dispensing device containing a film forming material; and applying a film forming material to an area of skin, for pre-treating an area of skin to reduce friction and thereby reduce the risk of acquiring chafing and/or a blister.Type: ApplicationFiled: May 26, 2010Publication date: October 13, 2011Applicant: Brands Worldwide Holdings I.P. Pty LimitedInventors: Steven Sher, Amit Saha
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Patent number: 8034817Abstract: The invention relates to inhalable quinolonecarboxylic acid derivative compositions for local control of diseases of the respiratory organs, in particular of lung diseases.Type: GrantFiled: February 10, 2004Date of Patent: October 11, 2011Assignee: Bayer Pharma AktiengesellschaftInventors: Rainer Endermann, Harald Labischinski, Christoph Ladel, Uwe Petersen, Ben Newton
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Publication number: 20110236321Abstract: Described herein are emulsions and compositions for the treatment of acne vulgaris. The emulsions may be formulated as aerosol compositions. The aerosol propellant may be a hydrofluoroalkane propellant. The emulsions or compositions may comprise clindamycin phosphate and a buffer salt, and may exhibit decreased rates of clindamycin phosphate hydrolysis. Also described are methods of treating acne vulgaris, comprising the step of applying to an affected area of a subject in need thereof a therapeutically-effective amount of an inventive emulsion or aerosol composition.Type: ApplicationFiled: March 22, 2011Publication date: September 29, 2011Applicant: Precision Dermatology, Inc.Inventors: Mark W. Trumbore, Wendy Schilling, Ravi K. Varanasi
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Publication number: 20110229418Abstract: Compositions and methods for treating and preventing cancer, particularly lung cancer, are provided.Type: ApplicationFiled: March 15, 2011Publication date: September 22, 2011Inventor: Steven Lehrer
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Publication number: 20110223113Abstract: A pharmaceutical product includes a dosing aerosol containing a propellant, an effective quantity of adsorbent, a pharmaceutically active substance, substance formulation or substance mixture, and a packaging enclosing the adsorbent. A dosing aerosol is disclosed with the pharmaceutically active substance, substance formulation or substance mixture.Type: ApplicationFiled: May 19, 2011Publication date: September 15, 2011Inventors: Hans Hermann Weil, Christel Schmelzer
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Publication number: 20110223114Abstract: The present invention relates to an antimicrobial composition. It particularly relates to an antimicrobial composition for cleansing or personal care. It is an object of the present invention to provide antimicrobial compositions that have relatively fast antimicrobial action. Present inventors have surprisingly found that compositions comprising selected ingredients, namely thymol and terpineol, in selective proportions provide relatively quick antimicrobial action.Type: ApplicationFiled: October 8, 2009Publication date: September 15, 2011Inventors: Amit Chakrabortty, Srilaxmi Venkata Medepalli
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Publication number: 20110224675Abstract: Featured are a biocompatible, injectable, self-setting, cohesive, bone-bonding and remodeling calcium phosphate composite material and its use in methods of repairing defective bone, e.g., in vertebroplasty augmentation and kyphoplasty.Type: ApplicationFiled: April 15, 2009Publication date: September 15, 2011Inventors: Aliassghar N. Tofighi, Aron D. Rosenberg, Tak Lung Chang, Michael Strunk
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Patent number: 8017106Abstract: The present invention provides stable aerosol cream mousse composition, preferably hair care composition, that can provide enhanced touch, combability, alignment and volume reduction to the hair, with low or reduced greasy, oily hair feel, while being formulated having a thick, rich, creamy, mousse-type rheology with excellent spreading, perception of spreading, and feel. The aerosol composition is based on the combination of component (A) a cationic surfactant, which is generally a quaternary ammonium compound such as e.g., ditallow dimethyl ammonium chloride; (B) a fatty alcohol, such as cetyl and stearyl alcohol; and (C) carbon dioxide.Type: GrantFiled: January 17, 2008Date of Patent: September 13, 2011Assignee: The Procter & Gamble CompanyInventors: Walter Keller, Christian Springob, Bianka Schmich, Timothy Müller
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Patent number: 8012524Abstract: The present invention aims at providing novel spread and edible oil having excellent characteristics as a spread or an edible oil. An edible oil and a suitable emulsifier, in a water-in-oil type emulsion is filled with a suitable gas propellant into an aerosol container, and the emulsion is discharged as mousse form at the time of jetting.Type: GrantFiled: December 19, 2003Date of Patent: September 6, 2011Assignee: Meiji Dairies CorporationInventors: Yoshinori Komatsu, Shigeru Tamai
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Publication number: 20110212033Abstract: A waterless foamable pharmaceutical composition suitable for external administration is disclosed. The composition includes a foamable carrier least one liquefied or compressed gas propellant. The foamable carrier includes at least one liquid oil; at least one silicone and at least one least one stabilizing agent; wherein the stabilizing agent selected from the group consisting of about 0.01% to about 25% by weight of at least one surface-active agent alone or on combination with a foam adjuvant; and about 0% to about 5% by weight of at least one polymeric agent alone or on combination with a foam adjuvant; and mixtures thereof. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.Type: ApplicationFiled: June 7, 2010Publication date: September 1, 2011Applicant: Foamix Ltd.Inventors: Dov TAMARKIN, Helena Shifrin, Rita Keynan, Enbal Ziv, Tal Berman, David Schuz, Elana Gazal
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Publication number: 20110212034Abstract: A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administrable medicament in combination with an effervescent for use in promoting absorption of the medicament in the oral cavity. The use of an additional pH adjusting substance in combination with the effervescent for promoting the absorption drugs is also disclosed.Type: ApplicationFiled: May 2, 2011Publication date: September 1, 2011Applicant: CIMA LABS INC.Inventors: Sathasivan Indiran Pather, Rajendra K. Khankari, Jonathan D. Eichman, Joseph R. Robinson, John Hontz
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Publication number: 20110212151Abstract: A synergistic insecticidal composition is formed containing a Chloronicotynyle compound and a Pyrethroids compound. The Chloronicotynyle compound is provided in an amount preferably ranging from 0.1 to 5.0% by weight of the synergistic insecticidal composition. The Pyrethroids compound is provided in an amount preferably ranging from 1 to 60% by weight of the synergistic insecticidal composition. The synergistic insecticidal composition also preferably includes 35 to 98.90% by weight of conventional agriculturally acceptable carrier(s) and/or excipients.Type: ApplicationFiled: March 8, 2011Publication date: September 1, 2011Applicant: UNITED PHOSPHORUS, LIMITEDInventors: Prakash Mahadev Jadhav, Jaidev Rajnikant Shroff
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Publication number: 20110206620Abstract: Described herein are materials and methods for treating dry eye disease in a subject.Type: ApplicationFiled: February 25, 2011Publication date: August 25, 2011Applicant: Schepens Eye Research InstituteInventors: Reza Dana, Sunil Chauhan
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Publication number: 20110206621Abstract: The invention described herein relates to an oral transmucosal solid dosage form useful in treating nicotine addiction or as a nicotine substitute or replacement. By virtue of the formulation in combination with nicotine, the invention transmucosally delivers an effective amount of nicotine to the recipient while permitting the accomplishing of such, and manufacture of such, using a relatively small, convenient and orally comfortable dosage form (e.g., tablet) size.Type: ApplicationFiled: January 11, 2011Publication date: August 25, 2011Applicants: Cephalon, Inc., CIMA LABS INC.Inventors: Vikas Agarwal, Brian I. Hague, Rajendra K. Khankari
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Patent number: 8003081Abstract: A method for improvement of tolerance for therapeutically effective agents delivered by inhalation comprising a pretreatment of a patient with a nebulized lidocaine or a lidocaine-like compound administered immediately or up to about thirty minutes before administration of the primary therapeutically effective agent. The pretreatment of the patient with the nebulized lidocaine or a lidocaine-like compound improves airway tolerance and deposition of the agent in the lungs and makes such deposition more safe, efficacious, controllable and predictable. The method of the invention is especially useful for enhancement of deposition of immunosuppressive agents in the lung(s) of transplant patients, improved tolerance of the drugs by reducing cough, and improving pulmonary drug deposition.Type: GrantFiled: September 10, 2008Date of Patent: August 23, 2011Assignee: Gilead Sciences, Inc.Inventors: Thomas Hofmann, Alan Bruce Montgomery, Kevin Stapleton, William R. Baker
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Publication number: 20110200539Abstract: Disclosed are sprayable compositions containing red vine leaf extract, which can be sprayed onto the skin using suitable spray devices.Type: ApplicationFiled: August 26, 2008Publication date: August 18, 2011Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Katrin Buszello, Oliver Ludwig Freichel, Martin Langer, Bernd Plohmann
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Publication number: 20110200538Abstract: The present invention relates to alternan-carboxylic acid esters, to processes for the preparation of alternan-carboxylic acid esters, and to compositions comprising alternan-carboxylic acid esters and to the use of alternan-carboxylic acid esters. The invention relates to alternan-carboxylic acid esters which are emulsifiers.Type: ApplicationFiled: October 16, 2009Publication date: August 18, 2011Applicant: Bayer CropScience AGInventors: Claus Frohberg, Waltraud Vorwerg, Sylvia Radosta
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Patent number: 7998463Abstract: An anti-tussive nebulized solution for targeted delivery of lidocaine into conducting and central airways. A method for treatment of cough and tussive attacks or episodes using said lidocaine solution. A nebulized lidocaine solution administered in daily dose from about 10 mg to 80 mg of lidocaine dissolved in a saline and nebulized into an aerosol having a mass median aerodynamic diameter 3 ?m to 10 ?m and a geometric standard deviation less than 1.7 using an electronic nebulizer.Type: GrantFiled: September 10, 2008Date of Patent: August 16, 2011Assignee: Gilead Sciences, Inc.Inventors: Thomas Hofmann, Alan Bruce Montgomery, Kevin Stapleton
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Publication number: 20110195031Abstract: Provided are methods and kits for administering progestogen as a glucocorticoid sensitizer to restore corticosteroid sensitivity or reverse the glucocorticoid insensitivity or enhance glucocorticoid sensitivity, in order to treat one or more glucocorticoid insensitivity related diseases or conditions. For example, these include methods for reversing the glucocorticoid insensitivity in a subject having no history of menstrual cycle-related exacerbation or allergy to self-hormones, particularly progesterone, such as premenstrual or perimenstrual deterioration in the symptoms, e.g., premenstrual worsening of atopic dermatitis or premenstrual exacerbations of asthma, and exhibiting relatively or totally refractory responses to glucocorticoid therapy, e.g., glucocorticoid resistance. The methods and kits provide for the administration of a sex hormone to the subject who is corticosteroid dependent or corticoid resistant or unresponsive or intolerant to corticosteroids.Type: ApplicationFiled: February 7, 2011Publication date: August 11, 2011Applicant: PRAIRIE PHARMACEUTICALS, LLCInventor: Tao Tom Du
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Publication number: 20110189103Abstract: A fosfomycin plus tobramycin combination formulation for delivery by aerosolization is described. The concentrated fosfomycin tobramycin combination formulation containing an efficacious amount of fosfomycin plus tobramycin is able to inhibit susceptible bacteria. Fosfomycin and tobramycin are formulated separately in a dual ampoule such that when reconstituted, the pH is between 4.5 and 8.0 or as a dry powder. The method for treatment of respiratory tract infections by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5?, produced by a jet or ultrasonic nebulizer (or equivalent) or dry powder inhaler.Type: ApplicationFiled: April 13, 2011Publication date: August 4, 2011Inventors: William Baker, David MacLeod
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Publication number: 20110190219Abstract: Methods for treating cancer (e.g., metastatic cancer to the lung or chronic lymphocytic leukemia) in patients are described that include administrating an aerosolized granulocyte macrophage colony stimulating factor to the patients. Methods for stimulating an immune response in patients also are described.Type: ApplicationFiled: March 7, 2008Publication date: August 4, 2011Inventor: Svetomir N. Markovic
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Publication number: 20110180445Abstract: A cosmetic tablet or capsule for direct delivery of active ingredients onto a keratinous substrate is provided composed of a tablet or capsule having an outer shell and inner cavity containing at least one active ingredient optionally in a physiologically acceptable carrier. Active ingredients contained and delivered by the cosmetic tablet include fragrances, perfumes, serums, lotions, creams, sunscreens, moisturizers, body wash, shower gels, foundations and a plethora of products for making-up or applying to the skin. Other ingredients, such as scents, dyes, adjuvants, moisturizers, and/or colorings may be included in the composition and hosed in the tablet or capsule. In one embodiment the outer shell of the tablet/capsule is substantially water soluble and the active ingredients are appointed to be released by dissolving or puncturing the outer shell.Type: ApplicationFiled: April 5, 2011Publication date: July 28, 2011Inventor: Marni Markell Hurwitz
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Publication number: 20110182828Abstract: The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers, or isomers of said compounds), having the general structure: wherein L, R1, R2, R3, R4, R5, and R6 are selected independently of each other and as defined herein. The present invention also provides compounds (and salts, solvates, esters, prodrugs, tautomers, and isomers) of Formulas II, III, IV, V, and VI, as defined herein. Also provided are pharmaceutical compositions, methods of preparing, and methods of using such compounds in the treatment and prophylaxis of a wide range of immune, autoimmune, and inflammatory diseases and conditions.Type: ApplicationFiled: December 18, 2008Publication date: July 28, 2011Applicant: Schering CorporationInventors: John C. Anthes, Kevin D. Mccormick, John A. Hey, Robert G. Aslanian, Purakkattle J. Biju, Michael Y. Berlin, Daniel M. Solomon, Phillippa H. Solomon, Hongwu Yang, Yeon-Hee Lim, Yoon Joo Lee, Rema Danielle Bitar