Chewable Tablet Or Wafer Patents (Class 424/441)
  • Patent number: 11253501
    Abstract: Embodiments described herein are directed to novel pharmaceutical compositions comprising a plurality of microgranules comprising nitroimidazole compounds, and uses of these pharmaceutical compositions in the treatment of bacterial vaginosis.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: February 22, 2022
    Assignee: LUPIN INC.
    Inventors: David Palling, Ronald S. Vladyka, Joseph Amprey
  • Patent number: 11090386
    Abstract: The present invention provides a method for suppressing bitterness of a quinoline derivative.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: August 17, 2021
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Kentaro Nagane, Yosuke Ueki, Shusuke Sano, Takahisa Sakaguchi
  • Patent number: 11083195
    Abstract: Insecticidal compositions containing an insecticidal effective amount of erythritol and sucralose, and optionally a carrier. Insecticidal bait composition containing (a) an effective amount of the insecticidal composition, (b) one or more food materials, and (c) optionally a phagostimulant. Method for killing insects involving treating an object or area with a composition containing an insects killing effective amount of the insecticidal composition.
    Type: Grant
    Filed: June 17, 2020
    Date of Patent: August 10, 2021
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventors: Man Y Choi, Jana C. Lee
  • Patent number: 11077067
    Abstract: Provided are pharmaceutical compositions and methods for preparing pharmaceutical compositions comprising Ibuprofen using solventless mixing methods. Excess coating material that is not bound to coated Ibuprofen may be removed by a sieving process. Coating and dosing ratios can also be optimized to minimize the amount of excess unbound coating material. Additionally, the compositions can be formulated to preserve the functional coating of coated Ibuprofen and to minimize aeration of Ibuprofen when mixed into suspension.
    Type: Grant
    Filed: August 31, 2020
    Date of Patent: August 3, 2021
    Assignee: Catalent U.K. Swindon Zydis Limited
    Inventors: Rosaleen McLaughlin, Simon Andrew Martyn Howes, Craig Wheadon, Jonathon Whitehouse, Adam Parker
  • Patent number: 10980831
    Abstract: The invention relates to a solid pharmaceutical tablet for oral delivery, the tablet comprising calcium carbonate in an amount of more than 30% by weight of the tablet and organic water-insoluble components in an amount of more than 20% by weight of the tablet, wherein the tablet is designed to be masticated into a coherent residual containing the organic water-insoluble components, and wherein the tablet is adapted to release more than 80% of the calcium carbonate within 5 minutes of mastication.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: April 20, 2021
    Assignee: FERTIN PHARMA A/S
    Inventor: Jesper Neergaard
  • Patent number: 10757967
    Abstract: A method of manufacturing flavorant particles includes melting a food grade wax and a flavorant into a molten wax; solidifying the molten wax; and grinding the solidified molten wax into a plurality of flavorant particles. Another method of manufacturing flavorant particles includes melting a food grade wax and a flavorant into a molten wax, the molten wax having a melting temperature between about 50° C. to about 70° C.; and spray-chilling the molten wax into at least one solid flavorant particle, the solid flavorant particle having a diameter of between about 0.1 mm to about 2.0 mm.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: September 1, 2020
    Assignee: Altria Client Services LLC
    Inventor: Munmaya K. Mishra
  • Patent number: 10668012
    Abstract: Sustained release compositions in tablet or multiparticulate forms comprising (a) an active ingredient, (b) a primary sustain release agent, (c) a wax-like agent, and (d) a bulking or spheronizing agent are provided. The compositions are chewable and/or taste masked. Oral dosage forms comprising such compositions and methods for preparing and using such compositions and dosage forms are also provided.
    Type: Grant
    Filed: September 4, 2009
    Date of Patent: June 2, 2020
    Assignee: Farnam Companies, Inc.
    Inventors: Andrew Xian Chen, Patricia D Kigin, Hai Liang Chen, Jun Fan
  • Patent number: 10596138
    Abstract: Liquid nutritional compositions that include functional ingredients such as beta-hydroxy-beta-methylbutyrate, docosahexaenoic acid, and lutein are disclosed. The nutritional compositions are useful to promote at least one of physical performance (e.g., body composition, muscle mass, muscle strength) and cognitive function (e.g., focus, attention, alertness, executive function) in an individual. The functional ingredients are incorporated into the nutritional composition in such a way that they do not adversely affect the desirable properties of the nutritional composition such as, for example, nutritional value, stability, solubility, taste, and mouthfeel.
    Type: Grant
    Filed: September 13, 2016
    Date of Patent: March 24, 2020
    Inventors: Gaurav Patel, Tapas Das, Rockendra Gupta
  • Patent number: 10561617
    Abstract: The present invention relates to a modified-release composition comprising orlistat and acarbose, comprising individually distinct parts with different release patterns: a) a first part, G1, comprising from about 5 to about 70% w/w of the total dose of acarbose, b) a second part, G2A, comprising from about 30 to about 95% w/w of the total dose of acarbose, c) a third part, G2B, comprising from about 10 to about 90% w/w of the total dose of orlistat, and d) a fourth part, G3, comprising from about 10 to about 80% w/w of the total dose of orlistat, and the total concentration of acarbose and orlistat, respectively, in the composition is 100% w/w.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: February 18, 2020
    Assignee: EMPROS PHARMA AB
    Inventors: Göran Alderborn, Anders Forslund, Ulf Holmbäck, Hans Lennernäs, Jan Stefan Persson Grudén
  • Patent number: 10426726
    Abstract: The invention relates to a medical chewing gum comprising gum base polymers and an active pharmaceutical ingredient, the gum base polymers comprising polyvinyl acetate and vinyl laurate-vinyl acetate copolymer in an amount of more than 90% by weight, wherein the gum base polymers include 20-95% by weight of polyvinyl acetate and -80% by weight of vinyl laurate-vinyl acetate copolymer, and wherein the chewing gum contains no polyterpene resins and no resins based on gum rosin, wood rosin or tall oil resin.
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: October 1, 2019
    Assignee: FERTIN PHARMA A/S
    Inventor: Jesper Neergaard
  • Patent number: 10213424
    Abstract: Provided herein, generally, are pharmaceutical formulations, e.g., injectable pharmaceutical formulations with improved stability, comprising morphine sulfate or a hydrate thereof, and methods of producing and using the same. Also provided herein are kits comprising the formulations, e.g., injectable morphine formulations.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: February 26, 2019
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventors: Alain Cuine, Didier Hoarau, Pauline Romain
  • Patent number: 10206949
    Abstract: A composition and an article of manufacture providing relief of indigestion, heartburn, GERD and some hangovers. The composition is an oleophilic colloidal suspension of a finely ground powder of USP calcium carbonate suspended in a usually tasteless edible oil; wherein the suspension has a weight ratio range of oil to calcium carbonate that is from about 1.0 (oil) to 0.25 (calcium carbonate) to about 1.0 (oil) to 2.2 (calcium carbonate); and a single dose has a calcium carbonate weight range from about 200 mg to about 1000 mg. The composition can include other foods and additives so that it may be used and dispensed in a plurality of delivery systems and foods. The oleophilic colloidal suspension can be dispensed as a soft-gel.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: February 19, 2019
    Inventors: Ofer Agam, Francis Rhett Brockington
  • Patent number: 10159647
    Abstract: The present invention relates to a dispersible tablet comprising crospovidone, notably a tablet comprising crospovidone and a ?-lactam antibiotic such as amoxicillin, to a method for preparing said tablet and to the use of said tablet.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: December 25, 2018
    Assignee: DSM Sinochem Pharmaceuticals Netherlands B.V.
    Inventor: Abraham Cornelis Lardée
  • Patent number: 10092651
    Abstract: Provided is a fast dissolving film composition comprising a medically active component as an active ingredient, in which the bitter taste of the active ingredient is masked and the fast dissolving film composition has a high content of 50% or higher. More particularly, provided is a pharmaceutical composition which comprises sildenafil or pharmaceutically acceptable salts thereof as an active ingredient, and which comprises a combination of a specific bitter taste masking agent to achieve masking of a bitter taste. Further, provided is a fast dissolving film composition which comprises a combination of a specific plasticizer to mask a bitter taste, and in which the physical properties of the high-content film are excellent.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: October 9, 2018
    Assignee: SEOUL PHARMA CO., LTD.
    Inventors: Hyun Jun Jeong, Ik Hyeon Chang, Dal Geun Kim, Jin Hoo Lee, Jin Hee Um, Hyun Soo Kim, Kyung Tae Jung, Kyu Jeong Yeon, Jin Gyu Park
  • Patent number: 10016500
    Abstract: Compositions and methods for treating bacterial, fungal, and yeast infections in wounds are disclosed. The disclosed poloxamer-based pharmaceutical composition includes a micronized poloxamer composition base combined with one or more suitable active pharmaceutical ingredients (APIs), such as, antibacterial or antifungal, thereby resulting in a synergistic effect for the APIs. The micronized poloxamer composition within poloxamer-based pharmaceutical composition includes poloxamer 407 and poloxamer 188. Poloxamer-based pharmaceutical composition exhibits a particle size average of about 50 ?m, which enhance APIs solubility. Additionally, poloxamer-based pharmaceutical composition can be delivered in a plurality of dosage forms, such as, powders, sprays, ointments, pastes, creams, lotions, solutions, and patches, among others.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: July 10, 2018
    Assignee: Professional Compounding Centers of America
    Inventor: Daniel Banov
  • Patent number: 9993497
    Abstract: Disclosed herein are compositions, methods and uses utilizing alginate compositions, for treating, preventing and/or reducing liver damage induced by a hepatotoxic agent, and for treating a medical condition treatable by a hepatotoxic agent, in which an alginate composition is administered prior to, concomitant with, or shortly after exposure to a hepatotoxic agent. Also disclosed are pharmaceutical compositions comprising a hepatotoxic agent and an alginate composition and uses thereof for treating medical conditions treatable by the hepatotoxic agent.
    Type: Grant
    Filed: December 30, 2013
    Date of Patent: June 12, 2018
    Assignees: Hadasit Medical Research Services and Development Ltd., B.G. Negev Technologies & Applications Ltd., at Ben-Gurion University
    Inventors: Smadar Cohen, Yaron Ilan, Eyal Shteyer, Ami Ben-Ya'acov
  • Patent number: 9974805
    Abstract: The invention relates to a pharmaceutical composition in the form of pourable granules or a chewable tablet containing at least one phosphate binding substance and at least one effervescent agent. The composition may be taken orally without adding water.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: May 22, 2018
    Inventors: Kai Strothmann, Friedrich Schulze, Johannes Bartholomaeus, Eva Fries-Schaffner, Astrid Bonert
  • Patent number: 9901546
    Abstract: An orally disintegrable tablet, of the present invention, which comprises (i) fine granules having an average particle diameter of 400 ?m or less, which fine granules comprise a composition coated by an enteric coating layer, said composition having 10 weight % or more of an acid-labile physiologically active substance and (ii) an additive, has superior disintegrability or dissolution in the oral cavity so that it can be used for treatment or prevention of various diseases, as an orally disintegrable tablet capable of being administered to the aged or children and easily administered without water. Also, because the tablet of the present invention contains fine granules having the average particle diameter such that it will not impart roughness in mouth, it can be administered easily without discomfort at the administration.
    Type: Grant
    Filed: May 27, 2014
    Date of Patent: February 27, 2018
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Toshihiro Shimizu, Shuji Morimoto, Tetsuro Tabata
  • Patent number: 9833461
    Abstract: A composition comprising a tetrahydrocannabinoid compound, a second cannabinoid and a corticosteroid is provided. The composition is useful to treat psoriasis and related conditions in a mammal.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: December 5, 2017
    Assignee: CTT Pharma Inc.
    Inventor: Pankaj Modi
  • Patent number: 9717693
    Abstract: Microparticles or granules intended for use in the zootechnical field, constituted by a core which contains a substance having a pharmacological action, a food supplement or a diagnostic medium, intimately mixed or adsorbed with a hydrated silicate of magnesium, aluminum, calcium and sodium (smectite, montmorillonite or bentonite); the core is coated with a double fatty layer constituted by two fats or waxes, of which the one having the highest melting point constitutes the inner layer while the one having the lowest melting point is arranged so as to form the outer layer.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: August 1, 2017
    Inventors: Ruggero Bettini, Lauro Arduini, Francesca Bertolini, Claudia Camellini
  • Patent number: 9649274
    Abstract: An effervescent chewable dosage form that comprises a pH neutralization agent, an acid, and an effervescent agent. The chewable dosage form can also further comprise simethicone, a sweetener, and a lubricant. The pH neutralization agent can be calcium carbonate, the acid can be citric acid and the effervescent agent can be sodium bicarbonate.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: May 16, 2017
    Assignee: The Procter & Gamble Company
    Inventors: Mark Edward Stella, John Richard Entwisle, Jason William Newlon, Christine Louis Naykki
  • Patent number: 9452181
    Abstract: A pharmaceutical dosage system comprising (a) an effective amount of one or more of Doxylamine, an analog thereof, a derivative thereof, a prodrug thereof, a metabolite thereof and/or a salt thereof; (b) an effective amount of one or more of (i) Pyridoxine, (ii) an analog thereof, (iii) a derivative thereof, (iv) a prodrug thereof, (v) a metabolite thereof and (vi) a salt of any of (i)-(v); and (c) an effective amount of one or more compounds of formula (I) wherein R is H, PO3? or The system exhibits an improved pharmacokinetic profile relative to the current Diclectin®/Diclegis® formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting of pregnancy (NVP).
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: September 27, 2016
    Assignee: Duchesnay Inc.
    Inventors: Manon Vranderick, Jean-Luc St-Onge, Michele Gallo, Éric Gervais
  • Patent number: 9439958
    Abstract: A method of producing an immune response in a subject including the step of administering to the subject a dry powder vaccine composition having a dry powder containing a subunit antigen with virus-like particles, where the subunit antigen is stabilized by a polysaccharide-containing plant extract, and where mucosal vaccination results in an immune response which is not further enhanced by co-inclusion of adjuvants.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: September 13, 2016
    Inventors: Charles J. Arntzen, Melissa Herbst-Kralovetz
  • Patent number: 9439920
    Abstract: A pharmaceutical dosage system comprising (a) an effective amount of one or more of Doxylamine, an analog thereof, a derivative thereof, a prodrug thereof, a metabolite thereof and/or a salt thereof; (b) an effective amount of one or more of (i) Pyridoxine, (ii) an analog thereof, (iii) a derivative thereof, (iv) a prodrug thereof, (v) a metabolite thereof and (vi) a salt of any of (i)-(v); and (c) an effective amount of one or more compounds of formula (I) wherein R is H, PO3- or The system exhibits an improved pharmacokinetic profile relative to the current Diclectin®/Diclegis® formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting of pregnancy (NVP).
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: September 13, 2016
    Assignee: Duchesnay Inc.
    Inventors: Manon Vranderick, Jean-Luc St-Onge, Michele Gallo, Éric Gervais
  • Patent number: 9398776
    Abstract: A nutritional supplement for adults fifty years and older, and methods of use thereof, are provided that are designed to be most effective in optimizing health, improving vitality and immunity, and improving, aiding, eye and bone health.
    Type: Grant
    Filed: January 21, 2010
    Date of Patent: July 26, 2016
    Assignee: Wyeth LLC
    Inventors: Richard Cotter, Charles Mohs, Lisa Dispensa, Paula Ziegler
  • Patent number: 9333176
    Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: May 10, 2016
    Assignee: Delavau L.L.C.
    Inventors: Kevin W. Lang, James W. Dibble, Raya Levin, Gregory B. Murphy
  • Patent number: 9289389
    Abstract: The present invention aims to provide a matrix-type solid preparation that has high-level release controllability for suppressing drug release in the upper gastrointestinal tract and accelerating drug release in the lower gastrointestinal tract, and that solves of all the above drawbacks caused by combining a plasticizer. The present invention provides a method for producing a matrix-type pharmaceutical solid preparation that contains: (a) a methacrylic acid-based enteric polymer; (b) a sugar and/or a sugar alcohol, and (c) tolvaptan.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: March 22, 2016
    Inventor: Kai Suzuki
  • Patent number: 9232810
    Abstract: The present invention relates to a chewable soft capsule shell and a chewable soft capsule, and to a filled jelly sweet and a process for preparing a chewable soft capsule shell or filled jelly sweet, wherein the chewable soft capsule shell comprises gelatin 10%-50%, water retention agent 10%-40%, thickening agent 2%-20%, water 6%-20%, and said soft capsule shell has a thickness of 0.3-1.2 mm.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: January 12, 2016
    Inventors: Cuifeng Cao, Xuesi Zhu, Weiwei Wang
  • Patent number: 9089490
    Abstract: A tablet that rapidly disintegrates in the oral cavity comprising a compressed blend of rapidly dispersing microgranules prepared by granulating a sugar alcohol or a saccharide or a mixture thereof having an average particle size less than about 30 microns and a disintegrant, and a taste-masked microcapsule containing at least one drug, the microcapsule being prepared by granulating a pharmaceutically acceptable formulation comprising at least one drug in a therapeutically effective amount and at least one polymeric binder that improves resilience of the microgranules, wet milling the granulated mass, and microencapsulating the milled granules to provide microcapsules.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: July 28, 2015
    Assignee: Aptalis Pharmatech, Inc.
    Inventors: Gopi M Venkatesh, Ken Kangyi Qian, Shyam Vangala, James M Clevenger, Donald Guenther
  • Patent number: 9005652
    Abstract: A chewable pharmaceutical composition comprising phenylephrine, artificial sweetener, and a substantially aldehyde-free matrix is provided. The composition has phenylephrine stability suitable for a typical commercial product with a two year shelf life. A method of manufacture of the composition and a method of use are also provided.
    Type: Grant
    Filed: July 25, 2006
    Date of Patent: April 14, 2015
    Assignee: Wyeth
    Inventors: Josephine Fubara, Mark Mabry, Aaron Lewis Durr, Angela Taylor, Amanda Alley, David H. Giamalva, Manish Agrawal
  • Publication number: 20150098978
    Abstract: A tablet that includes a solid solution of soluble fiber and one or more sugar alcohols, the solid solution having a glass transition temperature of less than 40° C., and one or more additives dispersed in the solid solution such that at least one additive is released from the tablet when the tablet is chewed or dissolved within an oral cavity.
    Type: Application
    Filed: October 3, 2014
    Publication date: April 9, 2015
    Inventors: Feng Gao, Diane L. Gee, Phillip M. Hulan, Shuzhong Zhuang, William J. Burke, Gerd Kobal
  • Patent number: 8911769
    Abstract: The invention relates to pharmaceutical compositions suitable for oral administration in the form of edible films comprising diclofenac.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: December 16, 2014
    Assignee: Novartis AG
    Inventors: Gavin Murray Spencer, Alexander Mark Schobel, Greg Slominski, Stephan Meyer, Isabelle Rault
  • Patent number: 8906406
    Abstract: The invention relates to a mucoadhesive medicinal preparation for administering active substances in veterinary or humane medicine, containing at least one active substance, which preparation is characterized in that it is a mucoadhesive matrix disintegratable in aqueous media, which matrix contains at least one matrix-forming polymer and wherein at least one active substance is dissolved or dispersed, and in that the said preparation disintegrates or erodes within maximally 15 minutes after introduction in an aqueous medium or in body fluids, or in that the preparation initially gels within maximally 15 min after its introduction in an aqueous medium or in body fluids, and disintegrates or erodes within maximally 30 min after said introduction.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: December 9, 2014
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Tina Rademacher, Frank Seibertz, Petra Brandt, Markus Krumme, Christian Von Falkenhausen
  • Patent number: 8883191
    Abstract: A method for producing individually dosed active substance-containing and, in particular, aromatic-containing, film-shaped administration form, rapidly disintegrating upon contact with a liquid, wherein the aromatic is present as an internal, liposoluble phase in the form of liquid droplets distributed within an outer, solid but water-soluble phase, is characterized in that the said outer phase contains: at least 40% (w/w) polyvinyl alcohol 0 to 30% (w/w), of a surface-active substance, and that the constituent amount of the inner phase, relative to the outer phase, is between 0.1 and 30% (w/w), in each case relative to the water-free portions.
    Type: Grant
    Filed: December 26, 2003
    Date of Patent: November 11, 2014
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Michael Horstmann, Wolfgang Laux
  • Publication number: 20140322296
    Abstract: The present invention provides a microcapsule pharmaceutical composition of at least a bisquinoline drug. said microcapsule comprises a drug core of a pharmaceutically effective amount of a bisquinoline drug and a polymeric coating over the core. This microcapsule pharmaceutical composition has desirable pharmaceutical properties, including taste masking effect and a high stability.
    Type: Application
    Filed: March 21, 2014
    Publication date: October 30, 2014
    Inventors: Christian Stollberg, Giancarla Bianchi, Flavio Fabiani, Luigi Boltri
  • Patent number: 8865133
    Abstract: A bi-layer, oral adhering tablet (troche) made by pressing powders with a bi-layer tablet press, having greater than 80% acacia gum as an adhesive in an adhering layer. In a preferred embodiment, the tablet has about 99% acacia gum.
    Type: Grant
    Filed: May 4, 2007
    Date of Patent: October 21, 2014
    Assignee: OraHealth Corporation
    Inventors: Jeffrey T Haley, Steven Edwards
  • Publication number: 20140294916
    Abstract: An oral methylphenidate extended release tablet is described, which can be scored and still retain its extended release profile. The tablet contains a combination of an uncoated methylphenidate-ion exchange resin complex, a barrier coated methylphenidate-ion exchange resin complex-matrix, and an uncomplexed methylphenidate active component. Following administration of a single dose of the extended release methylphenidate chewable tablet, a therapeutically effective amount of methylphenidate is reached in less than about 20 minutes and the composition provides a twelve-hour extended release profile.
    Type: Application
    Filed: June 10, 2014
    Publication date: October 2, 2014
    Inventors: Yu-Hsing Tu, Ashok Perumal, Kalyan Kathala
  • Patent number: 8846075
    Abstract: The invention refers to a composition material that is intended for rapid transmucosal delivery in the mouth of a biologically active substance when in contact with saliva. The composition material comprises at least one ionic carbohydrate, having at least one biologically active substance ionically bound thereto, and at least one wetable non-soluble polymeric carbohydrate. The invention also refers to a method of preparing the composition material, which comprises the steps of: (a) providing a mixture of the at least one biologically active substance and at least one ionic carbohydrate in a solvent having a permissive pH for ionic bonding of the at least one biologically active substance to the at least one ionic carbohydrate; (b) mixing the mixture in the solvent for a period that is sufficient for allowing the ionic bonding to take place; and (c) recovering the mixture from the solvent.
    Type: Grant
    Filed: January 23, 2004
    Date of Patent: September 30, 2014
    Assignee: Magle Holding AB
    Inventors: Ingemar Jonsson, Hans Henrik Lidgard, Gustaf Plym Forshell
  • Publication number: 20140271783
    Abstract: A combination of sheets can be combined into an ingestible unit. The individual sheets can be prepared to have one or more functionalities, such as providing a biologically active agent, disintegrating and opening the unit, controlling release of an agent, facilitating absorption from the GI tract, as well as many others. The individual sheets can be selectively identified for combining into a multifunctional ingestible unit with a random or predetermined arrangement or stacking pattern. The individual sheets can be loose in a capsule or laminated together into a stacked layered structure. The combination of sheets can be pressed, laminated, tableted, or otherwise prepared into an ingestible unit. The ingestible unit can be predetermined to be useful for administering a drug, drug combination, multi-drug regimen as well as tailored to subject-specific multi-drug therapeutic regimens. The sheets can be loaded with any type of agent ranging from drugs to anti-counterfeit agents.
    Type: Application
    Filed: October 15, 2012
    Publication date: September 18, 2014
    Inventors: Rodolfo Pinal, Bo Zhou, Andrew Otte
  • Publication number: 20140255463
    Abstract: An energy tablet and method of manufacturing the same that successfully masks the bitter taste of caffeine which has precluded popularity of chewable energy tablets in the past.
    Type: Application
    Filed: October 24, 2012
    Publication date: September 11, 2014
    Applicant: KICKASS CANDY LLC
    Inventor: Todd Stutzman
  • Patent number: 8802130
    Abstract: A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administrable medicament in combination with an effervescent for use in promoting absorption of the medicament in the oral cavity. The use of an additional pH adjusting substance in combination with the effervescent for promoting the absorption drugs is also disclosed.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: August 12, 2014
    Assignee: Cephalon, Inc.
    Inventors: S. Indiran Pather, Rajendra K. Khankari, Jonathan D. Eichman, Joseph R. Robinson, John Hontz
  • Patent number: 8802145
    Abstract: The invention relates to a method of manufacture of fast-disintegrating solid dosage forms, characterized in that one or more structure building components in mixed solid powder form are dosed into cavities of blister packs or moulds, the remaining components dissolved in water dosed and added to the powder to form a moistened, plasticized mass, frozen to below ?20° C., and the water sublimed in high vacuum. In this way solid dosage forms are obtained with a similar porous structure as usually result from freeze drying processes, but the process requires much less water, which means considerably less time and less energy.
    Type: Grant
    Filed: October 27, 2005
    Date of Patent: August 12, 2014
    Assignee: Pantec AG
    Inventor: Kurt Heinz Bauer
  • Patent number: 8765174
    Abstract: A matrix formulation for a soft chewable capsule is provided which includes a gel-forming composition, a plasticizer, a polymer modifier, and water. The polymer modifier may be a carboxylic acid or other organic compound that alters the physical and/or chemical properties of the capsule formulation. A chewable soft capsule is also provided, having enhanced organo-leptic and processing properties. An active material may be delivered to a user using this dosage form. A method of forming the chewable soft capsule is also provided.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: July 1, 2014
    Assignee: Banner Pharmacaps Inc.
    Inventors: EmadEldin M. Hassan, Warren W. Kindt, Roger E. Gordon
  • Publication number: 20140141055
    Abstract: A process for the manufacture of semi-plastic pharmaceutical unit doses using a rotary moulding machine and semi-plastic pharmaceutical dosage units obtained by this process.
    Type: Application
    Filed: November 18, 2013
    Publication date: May 22, 2014
    Inventors: Dominique Kluger, Carsten Schmidt, Albin Hauler, David Schroeckenfuchs, Niki Waldron
  • Publication number: 20140134228
    Abstract: An edible wafer containing nutritional supplement formulations suitable for specific enhancement of cell and mitochondrial function comprises enriched formulations of phospholipids or phospholipid chemical precursors containing inulin and specifically identified concentrations of phosphatidylglycerol, phosphatidic acid and phosphatidylcholine, and mitochondrial and cell membrane phospholipid molecules as well as other desirable constituents. These edible wafer lipid combinations can be used to treat mitochondrial disorders associated with medical pathologies, chronic illnesses and syndromes, or to maintain lipid balance for normal mitochondrial function, and can be administered in many different forms.
    Type: Application
    Filed: January 10, 2014
    Publication date: May 15, 2014
    Applicant: Nutritional Therapeutics, Inc.
    Inventor: Robert A. Settineri
  • Patent number: 8685436
    Abstract: The invention relates to hydroxyflavanones, their salts and stereoisomers and their mixtures for suppressing or reducing the bitter and/or metallic taste impression. In addition, the invention relates to nutritional, nutritive or consumable preparations or oral pharmaceutical compositions, characterized in that these have an active content of hydroxyflavanones, their salts and stereoisomers or their mixtures.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: April 1, 2014
    Assignee: Symrise AG
    Inventors: Jakob Peter Ley, Gerhard Krammer, Günter Kindel, Ian-Lucas Gatfield, Manfred Müller
  • Patent number: 8679553
    Abstract: An herbal composition for providing a beneficial effect to the respiratory tract. The composition includes Thyme Leaf, Wild Cherry Bark, Cocoa Extract, Mullein Leaf Extract, and Boswellia Serrata. In particular, the composition may prevent or treat cough, specifically caused by exposure to smoke. Also described are methods of using the herbal composition.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: March 25, 2014
    Assignee: Aadvantics Pharmaceuticals, Inc.
    Inventors: Brian M. Levine, William E. Berger
  • Patent number: 8628794
    Abstract: The present invention is directed to palatable ductile chewable veterinary composition for oral administration. The composition is capable of killing endo-parasites and ecto-parasites and/or can be used for treating prophylactic or curative animal diseases, and it is useful for the treatment of any warm-blooded non-human animal, including herd animals, like horses, cattle, sheep or poultry and preferably pets like dogs and cats. It consists basically of (A) an effective amount of one or more ingredients that are active against animal pests, pathogens or animal diseases; (B) meat flavoring; (C) partially gelatinized starch; (D) a softener; and (E) up to 9% water.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: January 14, 2014
    Assignee: Novartis AG
    Inventor: Ute Isele
  • Patent number: 8623401
    Abstract: An orally administrable wafer is provided comprising at least one physiologically acceptable film forming agent. The wafer is formed by mixing the film-forming agent with an aqueous solution to form a gel and exposing the gel to a plurality of heating and cooling cycles. The wafer is rapidly dissolving and suitable for administration of pharmaceutical agents.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: January 7, 2014
    Assignee: Fenwafe Inc.
    Inventor: Pankaj Modi
  • Publication number: 20130309292
    Abstract: The invention relates to a tobacco alkaloid releasing chewing gum comprising tobacco alkaloid, gum base, and chewing gum ingredients, said gum base comprising elastomer and resin-compounds constituting an amount in the range of about 2 to 20% by weight of said chewing gum.
    Type: Application
    Filed: July 23, 2013
    Publication date: November 21, 2013
    Inventor: Carsten Andersen