Chewable Tablet Or Wafer Patents (Class 424/441)
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Patent number: 6294189Abstract: A method for manufacturing an antidotal food product containing activated charcoal is provided to combine a binder, a filler composition, water, flavoring and sweetener compositions with an activated charcoal to form wafers having a consistency emulating that of a baked cookie. The activated charcoal (110), binder (112), filler (114), water (116), and flavoring and sweetener compositions (118) are combined in a mixer (210) to form a slurry. The slurry is then processed in a spray dryer (220) to form granules. The granules are combined with a lubricant (122) in a blender (230). The dry mixture from blender (230) is then formed into wafers by a tableting type machine in a compression molding step (240). The wafers formed in the compression molding step (240) are then coated in an anti-dusting coating step (250). A sweet creme filling is applied between pairs of the wafers in a cookie sandwich assembly step (270).Type: GrantFiled: April 24, 1998Date of Patent: September 25, 2001Assignee: De Novo, Inc.Inventors: Michael A. Stang, Dudley A. Demarest, Jr.
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Patent number: 6290985Abstract: Methods and products for delivering a medicament or agent to an individual are provided as well as methods for producing the product. The product includes a coating having a medicament or agent. The medicament or agent is present within the coating that surrounds a tableted gum center (the water soluble portion and a water insoluble base portion). By chewing the gum, the medicament or agent is released from the product. Continuing to chew the chewing gum creates a pressure within the buccal cavity forcing the agent or medicament directly into the systemic system of the individual through the oral mucosa contained in the buccal cavity. This greatly enhances the absorption of the drug into the systemic system as well as the bioavailability of the drug within the system.Type: GrantFiled: January 11, 2001Date of Patent: September 18, 2001Assignee: Wm. Wrigley, Jr. CompanyInventors: Ronald L. Ream, Christine L. Corriveau, Gwendolyn Graff, Leonard Matulewicz
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Publication number: 20010021722Abstract: This invention relates to a pharmaceutical composition for oral administration comprising a carrier and, as an active ingredient, a monoamine oxidase B inhibitor, characterised in that the composition is formulated to promote pre-gastric absorption of said monoamine oxidase B inhibitor. A process for preparing such a composition and the use of such a composition for the treatment of Parkinson's disease, the treatment and/or prophylaxis of depression and the treatment and/or prophylaxis of Alzheimer's disease are also provided.Type: ApplicationFiled: November 17, 1997Publication date: September 13, 2001Inventors: FRANCESCA, MARY BREWER, EDWARD STEWART JOHNSON, ANTHONY CLARKE
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Patent number: 6287596Abstract: Quickly disintegratable compression-molded materials containing (a) fillers and (b) erythritol. These materials are highly disintegratable and soluble in the oral cavity or water and, therefore, can be easily taken. Also, they are highly hard and thus excellent in storage stability in the production and distribution stages. Owing to these characteristics, they can be appropriately blended with efficacious ingredients and used in the treatment or prevention of diseases in patients, in particular, the aged, infants or those having difficulty in swallowing.Type: GrantFiled: January 11, 1999Date of Patent: September 11, 2001Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Toshio Murakami, Hideaki Aritomi, Naoto Ueno
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Patent number: 6284270Abstract: The present invention relates to a means for creating a mass having structural integrity, including a rapidly disintegratable tablet for administration with or without the use of water. The present invention has a wide variety of different uses and applications. One embodiment is a tablet intended for oral administration. The tablet comprises at least one active ingredient and a mixture of excipients. The excipients provide desired characteristics and physical properties and when the tablet is sintered or heated, excellent tablet binding characteristics are obtained. The tablet is intended primarily for oral administration and dissolves in the presence of water. Also disclosed is a process for the preparation of a rapidly disintegratable tablet for administration with or without the use of water.Type: GrantFiled: August 4, 1999Date of Patent: September 4, 2001Assignee: Drugtech CorporationInventors: Yury Lagoviyer, R. Saul Levinson, Denis Stotler, Thomas C. Riley
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Publication number: 20010014442Abstract: A consumable product utilized to maintain and restore hair color comprises a substrate and an effective amount of a directly available amino acid (in pure or diluted form) (obtainable, usually upon digestion or hydrolysis, from peptides, polypeptides, proteins, and derivatives thereof such as acyl and amide forms) wherein the directly available amino acid is selected from the group consisting of tyrosine, phenylalanine and mixtures thereof. Included is a related method for maintaining and restoring hair color that comprises the steps of adding an effective amount of a directly available amino acid selected from the group consisting of tyrosine, phenylalanine and mixtures thereof to a consumable product to produce a supplemented consumable. An efficacious amount of the supplemented consumable may be fed to an animal to maintain and restore hair color in the animal.Type: ApplicationFiled: February 2, 2001Publication date: August 16, 2001Inventors: James G. Morris, Quinton R. Rogers
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Patent number: 6270790Abstract: The present invention relates to a compressed, chewable tablet containing at least one active ingredient, a water-disintegratable, compressible carbohydrate and a binder. These components are dry blended and compressed into convex-shaped tablet having a hardness of about 2 to about 11 kp/cm2 and friability less than 1%.Type: GrantFiled: August 18, 1998Date of Patent: August 7, 2001Assignee: MxNeil-PPC, Inc.Inventors: Ronni L. Robinson, James R. Damon, James R. Mossop, Michael D. Palmer
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Patent number: 6270807Abstract: A chewable dosage form containing a histamine H2-receptor antagonist in an amount which is effective to treat a gastrointestinal disorder is provided in a palatably acceptable form. The dosage form comprises granules containing the histamine H2-receptor antagonist, which are provided with a taste-masking coating comprising a water-insoluble, water-permeable methacrylate ester copolymer in which the coating is applied to the granules in an amount which provides a taste-masking effect for a relatively short period during which the composition is being chewed by a patient, but which allows substantially immediate release of the histamine H2-receptor antagonist after the composition has been chewed and ingested.Type: GrantFiled: March 2, 1999Date of Patent: August 7, 2001Assignee: L. Perrigo CompanyInventors: Douglas Willard Danielson, Shirish A. Shah
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Patent number: 6267985Abstract: The present invention relates to pharmaceutical compositions and methods for improved solubilization of triglycerides and improved delivery of therapeutic agents. Compositions of the present invention include a triglyceride and a carrier, where the carrier is formed from a combination of at least two surfactants, at least one of which is hydrophilic. Upon dilution with an aqueous solvent, the composition forms a clear, aqueous dispersion of the triglyceride and surfactants. An optional therapeutic agent can be incorporated into the composition, or can be co-administered with the composition. The invention also provides methods of enhancing triglyceride solubility and methods of treatment with therapeutic agents using these compositions.Type: GrantFiled: June 30, 1999Date of Patent: July 31, 2001Assignee: Lipocine Inc.Inventors: Feng-Jing Chen, Mahesh V. Patel
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Patent number: 6264974Abstract: Physostigmine, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b] indol-5ol methylcarbamate, administered buccally or sublingually in non-sustained release dosage form provides extremely prolonged blood levels. This active agent is physically compounded with materials of some or all of classes of ingredients that function as pH controls, preservative agents, viscosity control agents, absorption enhancers, stabilizing agents, solvents, and carrier vehicles. This compounding will produce a pharmaceutical composition in the form of a liquid, tablet, gel, patch or lozenge for administration of the active agent, Physostigmine, by absorption through the buccal or sublingual mucosa of the patient. This method of delivery of Physostigmine and similar compounds is useful for treatment of cognitive deficiencies and/or neurological function deficits, mood and/or mental disturbances in mammals including human beings.Type: GrantFiled: July 7, 1998Date of Patent: July 24, 2001Inventor: Maher N. Madhat
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Patent number: 6264925Abstract: The present invention relates to an oral care composition comprising a Cellulose Binding Domain and further ingredient conventionally used in oral care compositions, oral care products, and the use of CBDs for oral care purposes.Type: GrantFiled: April 8, 1999Date of Patent: July 24, 2001Assignee: Novozymes A/SInventors: Claus Crone Fuglsang, Rie Tsuchiya
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Patent number: 6261600Abstract: The present invention is directed to novel chewable or dissolvable nutritional supplements for improving the absorption of folic acid in humans and other animals and methods of using said supplements. The nutritional supplements contain folic acid and non-toxic acid neutralizing alkaline compounds in chewable or dissolvable forms.Type: GrantFiled: April 30, 1999Date of Patent: July 17, 2001Assignee: DrugTech CorporationInventors: Mitchell I. Kirschner, George Paradissis, R. Saul Levinson
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Patent number: 6258381Abstract: A tablet and process for making the same is provided. The tablet is made from a granular agglomerate comprising a mixture of at least one active ingredient and a binder. The granular agglomerate is heated to melt the binder only at or near its surface, and then cooled, such that the melted binder solidifies into a substantially continuous phase, thereby forming a fused layer on the outside of the tablet.Type: GrantFiled: February 11, 2000Date of Patent: July 10, 2001Assignee: McNeil-PPC, Inc.Inventors: Joseph R. Luber, Frank J. Bunick
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Patent number: 6258846Abstract: The present disclosure relates to novel nutritional compositions containing linoleic acid and/or linolenic acid which optimize child neurological development and provide improved nutritional support for women prior to and during lactation. The nutritional compositions are intended for use by women to optimize infant neurological development and provide improved nutritional support for women prior to, during and after lactation.Type: GrantFiled: June 1, 1999Date of Patent: July 10, 2001Assignee: Drugtech CorporationInventors: Marc S. Hermelin, R. Saul Levinson, George Paradissis
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Patent number: 6258379Abstract: A pharmaceutical dispensing kit that includes at least two different analgesic dosage units that have been formulated for use with each other, each of the analgesics being formulated for administration during a particular time of day and/or with relation to a particular event, the kit including a housing which contains said dosage units and which contains indicia identifying said dosage units and instructions coordinating use of the different dosage units together as a treatment regimen for pain. The dosage units may be packaged in bulk and distinguished by differences in geometry, size, markings, type of formulation (e.g., tablet versus soft gel capsule), and/or color, all types of indicia useful with this invention. A method for treating pain that uses the novel kit is also provided.Type: GrantFiled: July 12, 1999Date of Patent: July 10, 2001Inventors: Robert Weinstein, Allan Weinstein
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Patent number: 6254898Abstract: A nutraceutical composition, for the inhibition of photochemical damage to the skin and eyes induced by sunlight, particularly by exposure to ultraviolet radiation is disclosed. The blend is multifunctional and comprises a blend of chemopreventive natural products, which exert anti-radical mechanisms of prevention and intervention, anti-inflammatory effects, enhance the endogenous defense mechanisms, and also have the potential to reduce the radiation induced pigmentation. The active ingredients in the blend include green tea extract, lutein (zeaxanthin), lipoic acid, and selenomethionine.Type: GrantFiled: May 25, 2000Date of Patent: July 3, 2001Assignee: Protective Factors, Inc.Inventor: Anthony Joseph Bragaglia
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Patent number: 6251421Abstract: The present invention provides orally administrable pharmaceutical compositions containing an inhibitor of gastrointestinal lipase, and at least one compound selected from the group consisting of psyllium husk, its seeds and leaves thereof. Methods are provided for preventing and treating anal leakage of oil in a patient to whom a composition containing an inhibitor of gastrointestinal lipase is orally administered.Type: GrantFiled: September 25, 2000Date of Patent: June 26, 2001Inventor: Sarfaraz K. Niazi
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Patent number: 6248391Abstract: A dry film coating composition used to make a bright white film coating for nutritional supplements, pharmaceutical tablets, and the like, comprises dextrose, an auxiliary film-former, and titanium dioxide. Optionally, but advantageously, the coating composition also may include one or more of the following components: a plasticizer, a surfactant, a flow aid, and a preservative.Type: GrantFiled: July 16, 1997Date of Patent: June 19, 2001Assignee: BPSI Holdings, Inc.Inventors: Susan M. Grillo, Brian Korchok, Bruce Kinsey, Melanie Hartman, Stuart C. Porter, Rita Steffenino, George Reyes, Thomas J. Burke
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Patent number: 6248347Abstract: Disclosed are an assimilation accelerator which contains &bgr;-glucooligosaccharide as an active ingredient, a calcium-supplementing diet which contains &bgr;-glucooligosaccharide and a calcium material, and a method for accelerating calcium assimilation using the calcium assimilation accelerator.Type: GrantFiled: April 12, 1999Date of Patent: June 19, 2001Assignee: Nihon Shokuhin Kako Co., Ltd.Inventors: Sachiko Takase, Toshinao Goda, Takehiro Unno, Teruo Nakakuki
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Patent number: 6248363Abstract: The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein or separately administered. In one embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier including a substrate and an encapsulation coat on the substrate. The encapsulation coat can include different combinations of pharmaceutical active ingredients, hydrophilic surfactant, lipophilic surfactants and triglycerides. In another embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier being formed of different combinations of pharmaceutical active ingredients, hydrophilic surfactants, lipophilic surfactants and triglycerides. The compositions of the present invention can be used for improved delivery of hydrophilic or hydrophobic pharmaceutical active ingredients, such as drugs, nutrionals, cosmeceuticals and diagnostic agents.Type: GrantFiled: November 23, 1999Date of Patent: June 19, 2001Assignee: Lipocine, Inc.Inventors: Mahesh V. Patel, Feng-Jing Chen
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Publication number: 20010002998Abstract: Methods and products for delivering a medicament or agent to an individual are provided as well as methods for producing the product. The product includes a coating having a medicament or agent. The medicament or agent is present within the coating that surrounds a tableted gum center (the water soluble portion and a water insoluble base portion). By chewing the gum, the medicament or agent is released from the product. Continuing to chew the chewing gum creates a pressure within the buccal cavity forcing the agent or medicament directly into the systemic system of the individual through the oral mucosa contained in the buccal cavity. This greatly enhances the absorption of the drug into the systemic system as well as the bioavailability of the drug within the system.Type: ApplicationFiled: January 11, 2001Publication date: June 7, 2001Inventors: Ronald L. Ream, Christine L. Corriveau, Gwendolyn Graff, Leonard Matulewicz
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Patent number: 6241997Abstract: A chewable calcium composition and its associated method of manufacturing are disclosed. The chewable composition includes a lipid base and a micronized calcium salt substantially uniformly mixed with the lipid base such that the lipid base forms a continuous phase. The composition provides for a relatively large dose of calcium in a easy to take chocolate like, chewable form. The composition of the present invention is manufactured by providing the lipid base including a melting temperature. The lipid base is then heated to a temperature of approximately 120° F. such that the lipid base melts. After the lipid base melts, the micronized calcium salt is mixed with the lipid base to form a melted mixture such that the micronized calcium salt is substantially uniformly distributed in the melted lipid base.Type: GrantFiled: March 16, 1998Date of Patent: June 5, 2001Assignee: SMTM Group. LLCInventors: Alvin Kershman, Jeff Lynn Shear, Ronald David Mogel
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Patent number: 6238661Abstract: Compositions and methods for the prophylactic and therapeutic treatment of bacterial infections are disclosed which comprise administering to an individual an effective amount of a composition comprising an effective amount of lytic enzyme and a carrier for delivering the lytic enzyme. This method and composition can be used for the treatment of upper respiratory infections, skin infections, wounds, burns, vaginal infections, eye infections, intestinal disorders and dental problems.Type: GrantFiled: April 18, 2000Date of Patent: May 29, 2001Assignee: New Horizons Diagnostics Corp.Inventors: Vincent Fischetti, Lawrence Loomis
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Patent number: 6231900Abstract: A confectionery product, suitable for the relief of cough and cold like symptoms, includes from about 0.5% to about 80%, by weight, of a coolant composition and from about 20% to about 99.5%, by weight, of a flavour composition in separate, distinct and discrete regions thereof. The coolant and flavour compositions are adapted to provide different release profiles.Type: GrantFiled: October 2, 1998Date of Patent: May 15, 2001Assignee: The Procter & Gamble CompanyInventor: Bernhard Hanke
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Patent number: 6228347Abstract: A gel, paste, gum or lozenge composition for oral application to human gums to prevent and reduce symptoms of gum disease. The composition includes reduced glutathione and a source of selenium.Type: GrantFiled: September 29, 1998Date of Patent: May 8, 2001Assignee: Thione International, Inc.Inventor: Theodore Hersh
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Patent number: 6224904Abstract: The present invention relates to a compressed formulation containing 1,1-GPS (1-O-&agr;-D-glucopyranosyl-D-sorbitol) or a mixture of sweetening agents composed of 1,1-GPS, 6-0-&agr;-D-glucopyranosyl-D-sorbitol (1,6-GPS) and 1-0-&agr;-D-glucopyranosyl-D-mannitol (1,1 GPM).Type: GrantFiled: May 27, 1999Date of Patent: May 1, 2001Assignee: Sudzucker AktiengesellschaftInventors: Knut M. Rapp, Ingrid Willibald-Ettle
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Patent number: 6224905Abstract: A method for preparing solid rapidly disintegrating dosage forms shaped as biconvex tablets having symmetrical top and bottom surfaces and dosage forms obtainable thereby.Type: GrantFiled: December 3, 1998Date of Patent: May 1, 2001Assignee: Janssen Pharmaceutica N.V.Inventors: Janice Lawrence, Gary Posage
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Publication number: 20010000471Abstract: The present invention provides a pharmaceutical composition which is substantially free of unpleasant tastes and orally administrable which comprises:Type: ApplicationFiled: December 15, 2000Publication date: April 26, 2001Inventors: Robert W. Shen, Gerald A. Walter
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Patent number: 6221392Abstract: The invention is directed to a hard tablet that can be stored, packaged and processed in bulk. Yet the tablet dissolves rapidly in the mouth of the patient with a minimum of grit. The tablet is created from an active ingredient mixed into a matrix of a nondirect compression filler and a relatively high lubricant content.Type: GrantFiled: December 16, 1999Date of Patent: April 24, 2001Assignee: Cima Labs Inc.Inventors: Rajendra K. Khankari, John Hontz, Sara J. Chastain, Leo Katzner
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Patent number: 6214379Abstract: The present disclosure relates to novel dosage forms, drug delivery regimens, methods and pharmaceutical compositions which optimize the therapeutic effects of active therapeutic substances through the application of the concept of uneven dosing.Type: GrantFiled: June 1, 1999Date of Patent: April 10, 2001Assignee: KV Pharmaceutical CompanyInventor: Victor M. Hermelin
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Patent number: 6207192Abstract: Cetyl pyridinium chloride and other amphiphilic substances may be mixed with flavorants or therapeutics in accompaniment with such as bulking agents or sweeteners in order to prolong their duration of action at the site of attachment, which is a mucin coated surface for the purpose of providing the consumer with a more efficacious product. It is the concept of delayed dispensing that is the invention, the product being dispensed is only an illustration of the best mode.Type: GrantFiled: September 30, 1994Date of Patent: March 27, 2001Assignee: SDG, Inc.Inventor: John R. Lau
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Patent number: 6200601Abstract: This invention provides a nutritional supplement containing docosahexaenoic acid (DHA), antioxidants and anthocyanosides. The supplement is useful for improving night vision acuity, field of vision and adaptation to light.Type: GrantFiled: April 26, 1999Date of Patent: March 13, 2001Assignee: Amway CorporationInventors: David Gorenbein, Nagui Ibrahim
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Patent number: 6197329Abstract: The present disclosure is directed to novel nutritional anti-nausea compositions, anti-emetic compositions, and methods of using same. The compositions provide improved relief from nausea and/or vomiting. The compositions are particularly useful for pregnant women.Type: GrantFiled: May 3, 1999Date of Patent: March 6, 2001Assignee: Drugtech CorporationInventors: Marc S. Hermelin, Mitchell I. Kirschner, R. Saul Levinson
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Patent number: 6197334Abstract: A device for delivering a liquid, semiliquid or solid beneficial agent into the mouth of a human or animal is disclosed. The device has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device may be formulated in one of two forms: 1) one form comprises a wall surrounding a hollow compartment holding the beneficial agent. A passageway in the wall connects the agent with the exterior of the device. The wall is impermeable and, with the exception of the passageway, fluids may not enter into the hollow compartment, or escape from the hollow compartment into the mouth. The size and configuration of the passageway determines the rate at which the agent is released into the mouth.Type: GrantFiled: April 12, 1999Date of Patent: March 6, 2001Inventor: Donald V. Renda
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Patent number: 6197288Abstract: This invention pertains to a malodor counteractant composition comprising a malodor counteractant agent in an oral vehicle. The malodor counteractant agent is selected from the group consisting of, in percentages by weight: (A) (a) geranyl propionate; (b) benzyl benzoate; and (c) neryl acetate; (B) (a) citronellyl acetate; (b) benzyl benzoate; and (c) neryl acetate; (C) (a) benzyl benzoate; (b) geranyl propionate; and (c) citronellyl acetate; (D) (a) geranyl propionate; (b) citronellyl acetate; and (c) benzyl benzoate; (E) (a) citronellyl acetate; and (b) geranyl propionate; (F) (a) benzyl benzoate; and (b) neryl acetate; (G) (a) benzyl benzoate; (b) neryl acetate; (c) trimethyl (2,6,6) vinyl(6) tetrahydropyran; (d) citronella oil; and (e) and ethyl alcohol; and (H) (a) benzyl benzoate; (b) neryl acetate; (c) citronella oil; (d) geranyl acetate; (e) alpha ionone; (f) geranyl propionate; (g) linalool; and (e) and ethyl alcohol.Type: GrantFiled: October 16, 1997Date of Patent: March 6, 2001Assignee: Bush Boake Allen, Inc.Inventor: Amrit Singh Mankoo
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Patent number: 6190686Abstract: A ready-to-use water dispersible pigment composition containing at least 5% by weight of water is provided. The composition comprises a stable dispersion of a water-insoluble and/or hydrophobic natural pigment such as a carotenoid, curcumin, a porphyrin pigment or vegetables carbon black in the form of bodies of an average size which is at the most 10 &mgr;m is provided. The pigment bodies are dispersed without the use of a surface active substance in an aqueous phase comprising a hydrocolloid. The natural pigment in compositions which are useful for coloring of food products and pharmaceuticals do not migrate in the products. The compositions are useful in coating compositions for tablets and dragees.Type: GrantFiled: September 17, 1998Date of Patent: February 20, 2001Assignee: CHR. Hansen A/SInventors: Per Pihlmann Isager, Marianne Winning
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Patent number: 6165473Abstract: A rice cracker including Funori, which comprises not less than 50 wt % of rice powder, 1-20 wt % of Funori, and 1-20 wt % of sesame, and the method of producing said rice cracker, wherein said rice cracker contains a HIV-inhibiting element.Type: GrantFiled: June 9, 1999Date of Patent: December 26, 2000Inventor: Tomiko Kiyooka
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Patent number: 6165511Abstract: A polyol composition useful for the production of tablets for consumption. The polyol is obtained by co-spray drying or co-fluidized bed granulating at least two polyols, one of which is a non-hygroscopic polyol, and the non-hygroscopic polyol is present in an amount of at least 80% by weight. An optional binder may be present. An active medicament may be present.Type: GrantFiled: October 21, 1998Date of Patent: December 26, 2000Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Eugen Schwarz, Gernot Moschl, Karin Maul
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Patent number: 6156738Abstract: A novel diabetic supplement bar which includes about 10-60% by weight simple carbohydrate, about 1-25% by weight protein, about 2-40% by weight lipid and about 1-60%, preferably about 5-35% by weight complex carbohydrate. This formulation is particularly useful for the treatment or prevention of nighttime hypoglycemia in diabetic patients who require insulin injections.Type: GrantFiled: February 1, 1999Date of Patent: December 5, 2000Inventors: Stacey J. Bell, Robert C. Jones, Bruce R. Bistrian, R. Armour Forse
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Patent number: 6153220Abstract: A taste-masked micromatrix powder in which the ratio of a cationic copolymer synthesized form dimethylaminoethyl methacrylate and neutral methacrylic acid esters compared to a drug having poor organoleptic properties is greater than 2 to 1, preferably 4 to 1, most preferably 6 to 1 (wt/wt). Taste masked immediate release micromatrix powders can be formed by spray drying the drug and cationic copolymer whereas sustained release micromatrix powders can be formed by granulating controlled release powders, which can be made by spray drying the drug with a retarding polymer, with the cationic copolymer. The immediate release or sustained release taste-masked powders of this invention can be incorporated into conventional oral dosage forms such as sprinkles, suspension, fast melt tablets, chewable tablets or effervescent tablets.Type: GrantFiled: September 30, 1998Date of Patent: November 28, 2000Assignee: Elan Corporation, plcInventors: Kenneth Iain Cumming, Elaine Harris
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Patent number: 6149939Abstract: Dissolvable oral tablets and mini-bars which contain healthful ingredients. The products contain a multitude of discrete, extruded sections containing different healthful ingredients. A wide variety of active ingredients includes oxygen enhancers, vitamins, enzymes, dehydrated foods, pycnogenols, food supplements, soy proteins, herbs, roots, and mints. The tablets and mini-bars may be prepared by extruding discrete sections and matrix, all containing active ingredients, cutting the resulting shape for the tablet and mini-bar, and coating with dehydrated food. The tablets and mini-bars may supply needed active ingredients following natural disasters or prior to surgery or may be taken for general use. The products may be contained in a thermal insulating wrapper having an inner piece, an outer piece, and a corrugated piece between the inner and outer pieces.Type: GrantFiled: October 19, 1998Date of Patent: November 21, 2000Inventors: Mathew A. Strumor, Judy S. Hartman
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Patent number: 6149933Abstract: A dietary supplement which is useful for the promotion of healthy hair and pigment restoration in human subjects is provided. The dietary supplement supplies useful nutrients for hair growth, development, and pigmentation. In some instances, the use of the present dietary supplement can retard, prevent, suppress, and/or even reverse the graying of hair. Thus, at least for some already-turned gray individuals, the natural hair color can be restored, and maintained, naturally without the use of dyes, colorants, or the like. The dietary supplement contains, in effective amounts, a copper salt; para-aminobenzoic acid or salts thereof; pantothenic acid or salts thereof; and vitamin B6 in an appropriate carrier.Type: GrantFiled: July 8, 1998Date of Patent: November 21, 2000Assignee: Summa Rx Laboratories, Inc.Inventor: Julia A. Nelson
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Patent number: 6146661Abstract: Chewable tablets prepared by incorporating a sugar alcohol with a dissolution endotherm of 20 calories or more per gram of a gastrointestinally active ingredient such as a mucous membrane repairing agent or an antacid are provided. The chewable tablets enable the gastrointestinally active ingredient to be orally administered with ease, without water and free from displeasing intrabuccal sensations characteristic of a gastrointestinally active ingredient.Type: GrantFiled: March 24, 1998Date of Patent: November 14, 2000Assignee: Chugai Seiyaku Kabushiki KaishaInventor: Kazuaki Hoshino
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Patent number: 6139865Abstract: A taste-masked microcapsule composition for administration of a drug is provided. The composition comprises microcapsules of drug and a substantially water-insoluble polymeric material, typically a cellulosic polymer. The microcapsule composition may be incorporated into any number of pharmaceutical formulations, including chewable tablets, effervescent tablets, powders, liquid dispersions, and the like. A method for masking the taste of drugs is also provided, involving a phase separation coacervation technique in which drug is coated with relatively high levels of a polymeric material. These high coating levels give rise to effective taste masking, while nevertheless allowing targeted release of drug, so that the drug is released shortly after passage through the mouth.Type: GrantFiled: October 1, 1997Date of Patent: October 31, 2000Assignee: Eurand America, Inc.Inventors: David R. Friend, Steve Ng, Rafael E. Sarabia, Thomas P. Weber, Jean-Marie Geoffroy
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Patent number: 6139864Abstract: Sugar alcohol mixtures are used as antimicrobially active compounds.Type: GrantFiled: October 20, 1998Date of Patent: October 31, 2000Assignee: Sudzucker AktiengesellschaftInventors: Tillmann Durr, Bodo Fritzsching, Michael Klingeberg, Jorg Kowalczyk, Gunhild Kozianowski, Markwart Kunz, Knut M. Rapp, Peter J. Strater
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Patent number: 6110495Abstract: A saliva-soluble stimulant unit comprising an active ingredient and optional ingredients comprising flavor and aroma additives incorporated in a gel prepared by gelling a water-binding gelling agent, in which the active ingredient comprises nicotine or other alkaloids with the same direction of activity, said unit having i) a texture profile, determined by texture profile analysis, with parameter values of firmness, hardness, brittleness, adhesiveness, elasticity, and cohesiveness within given ranges; (ii) a disintegration time within the range 5-60 minutes; and (iii) a nicotine content from 0.5 to 10 mg or a corresponding content of said alkaloids.Type: GrantFiled: November 17, 1997Date of Patent: August 29, 2000Inventor: Anders Dam
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Patent number: 6103260Abstract: The invention relates to antifoam oral solid dosage form preparations formed from a free flowing granular composition comprising an admixture of simethicone and either one or both of granular anhydrous tribasic calcium phosphate or dibasic calcium phosphate wherein the admixture is a uniform granular composition of not more than 1000 micron particle size which is suitable for compression into a solid dosage form for oral administration.Type: GrantFiled: July 17, 1997Date of Patent: August 15, 2000Assignee: McNeil-PPC, Inc.Inventors: Joseph R. Luber, Glenn Madison, Gerard McNally
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Patent number: 6099854Abstract: A flavonol-containing dry composition derived from wine and useful as a food supplement is provided wherein at least 25% of the composition derived from wine includes polyphenols and at least 1.0% w/w of the composition is flavonol.Type: GrantFiled: September 19, 1997Date of Patent: August 8, 2000Assignee: The Howard FoundationInventors: Alan Norman Howard, Shailja Vijay Nigdikar, Jayshri Rajput-Williams, Norman Ross Williams
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Patent number: 6093403Abstract: An herbal formulation is disclosed for treating and preventing non-insulin dependent diabetes mellitus (NIDDM) and other sugar imbalances. The herbal formulation is added to the diet of a person suffering from NIDDM in a lectin mixture containing the herbal formulation. The herbal formulation lowers the blood glucose and insulin levels. Adding the herbal formulation to the diet of persons who are in high risk of suffering from NIDDM has a significant effect on lowering blood glucose and insulin levels. Repeated doses of the herbal formulation in a lectin mixture will bring the blood glucose and insulin levels into a desired range. The herbal formulation is made from plant extracts and is useful in the prevention and treatment of sugar imbalances.Type: GrantFiled: February 25, 1999Date of Patent: July 25, 2000Assignee: Phytocell Research, Inc.Inventors: Yu Shu Huo, Sou Jen Lo, Wendell D. Winters
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Patent number: 6083531Abstract: The present invention relates to a solid pharmaceutical dosage form for oral administration, consisting essentially of(a) at least one active substance,(b) at least one filler,(c) at least one binding agent, and(d) optionally usual auxiliaries,which dosage form, however, does not contain agar;which dosage form is manufactured without applying any compression force to the mixture of the components (a), (b), (c) and (d); andwhich dosage form disintegrates when taken into the mouth within 15 seconds.Type: GrantFiled: October 7, 1998Date of Patent: July 4, 2000Assignee: Novartis Consumer Health S.A.Inventors: Pierre Humbert-Droz, Matthias Seidel, Rosa Martani