Abstract: The invention provides a pharmaceutical composition for the rectal administration of active principles which exhibit a prevalently topical medication action at the colon level, characterized in that said active principles are formulated in a fluid vehicle able to generate a foam on rectal administration.

Abstract: Absorbable composite materials are described that comprise a collagen matrix reinforced with a layer of a bioabsorbable polymer. A chemotherapeutic agent is dispersed in the composite material. The layer of bioabsorbable polymer is preferably a woven, nonwoven or knitted mesh layer of a synthetic bioabsorbable polymer such as polylactic/polyglycolic acid copolymer, or oxidised regenerated cellulose. The chemotherapeutic agent may be an antibiotic, an anaesthetic, an antiseptic or an anti-inflammatory. Strips of the composite material are inserted into the periodontal pocket, where they are retained in place and provide effective sustained release of the chemotherapeutic agent over an extended period.

Abstract: This invention provides pharmaceutical compositions for topical application containing high concentrations of the enzyme collagenase in non-aqueous excipients. The invention also provides a particular excipient, dextran, which is especially useful for admixture with collagenase and which can also be used to advantage with othr pharmaceutically active materials.

Abstract: The present invention relates to the use of unpigmented skin from flat fish as novel industrial source of collagen. As unpigmented skin, the ventral skin is used in particular, from sole, dab, turbot, brill. Native acid-soluble collagen is advantageously extracted and separated by precipitation from the supernatant. The invention makes it possible to improve the collagen yield at reduced cost while preserving the native properties of the protein, and in a reproducible manner.

Abstract: The present invention relates to single and multiple layer collagen films that are useful for improved sustained release delivery of pharmaceuticals.

Abstract: This invention is directed to oral parenteral and intestinal vaccines and eir use against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres.

Abstract: The present invention relates to a crosslinkable modified collagen which is soluble in water and/or in aprotic polar organic solvents and which contains free or substituted thiol groups carried by residues of cysteine or derivatives thereof, at least some of the residues being fixed to the collagen via spacer compounds. It further relates to processes for the production of the collagen. Applications are adhesives, biomaterials for prostheses, implants, or other medical articles.

Abstract: A plaster agent comprising a water impermeable or water semipermeable film (layer a), one tackifier layer (layer b) laminated on one surface of said layer a, and another tackifier layer (layer d) laminated on said layer b through an intermediary knitted fabric having a weight per unit area of 10 to 100 g/m.sup.2 (layer c) comprising hollow fibers having pores extending therethrough in the outer peripheral direction and containing substantially no medicine internally thereof, and at least one of said layer b and said layer d containing a vaporizable or non-vaporizable medicine.

Abstract: The invention relates to a wound secretion absorbing hydrogel of the following composition:______________________________________ a) 20 to 70%-wt of at least one multivalent alcohol b) 10 to 35%-wt of at least one natural thickener (biopolymer) c) 0.05 to 12%-wt of at least one uncross-linked copolymer of one or more vinylcar- boxylic acids and their salts (syn- thetic polymer) d) 0.05 to 10%-wt of a cross-linking agent e) 0 to 50%-wt of a water or physiological saline ______________________________________as well as to the use of this hydrogel as wound dressing.

Abstract: A pharmaceutical composition for use in the transdermal administration of a medicament to both humans and animals, which composition comprises at least ingredients (1) and (2) of the following ingredients (1), (2) and (3), namely: (1) an effective amount of a medicament adapted for transdermal administration; (2) a transdermally transporting effective amount of a carrier for the medicament, which carrier is selected from semisolids and liquids at ambient temperatures, and which carrier comprises at least one compound selected from esters of C.sub.8-24 fatty acids, pharmaceutically acceptable aliphatic polyhydroxy compounds and non-volatile paraffins; (3) an optional medicament selected from antiinflammatory agents and antihistamines, effective to mitigate any skin-incompatibility characteristic which may otherwise be present. Administration is preferably by means of a matrix which comprises a porous, absorbent, perforate and flexible laminar solid support, having the composition absorbed thereon.

Abstract: A non-adhesive matrix for use as a dosage form in the transdermal administration of a medicament to a mammal comprises a porous, non-adhesive, absorbent perforate solid support having absorbed thereon a mixture comprising a medicament adapted for transdermal administration and a pharmaceutically acceptable carrier for the medicament. The carrier consists essentially of at least one compound selected from esters of C.sub.8-24 fatty acids, pharmaceutically acceptable aliphatic polyhydroxy compounds and non-volatile paraffins.

Abstract: A novel wound dressing material is produced by a chemical treatment of animal fibers, particularly, wool, to strip off the keratin layers of the surfaces of the fibers so as to expose the non-keratin protein in the underlayers, which is hydrophilic. The wound dressing material provides healing and regenerating effects on the wounds, and can be produced at a low cost.

Abstract: A dressing for a wound having a porous structure of continuous pores throughout the dressing made of minute filaments arranged in three dimensions and filmy links (viewed at a magnification of about 35 to 350) connecting the filaments. The porous structure has pores defined by the filmy interconnections. In other words, the wound dressing has a continuous open-celled structure in an expanded foam. The wound dressing can advantageously be made of a highly biocompatible material, such as poly-.alpha.-amino acid.

Abstract: The film is obtained directly by extrusion from the lactic acid-based polymer plasticised beforehand by incorporation of 5 to 30% by weight of the polymer of a glycerol ester obtained from an acid containing 4 carbon atoms in its molecule.The film has an elongation at break of more than 300% and is particularly suitable for the production of medical dressings.

Abstract: The cutaneous atrophy associated with the use of steroids topically can be ameliorated using salts of certain .alpha.-hydroxyacids.

Abstract: An in vivo method is described for treating a subject for periodontal disease by placing a mixture of a glyceride composition and a therapeutic agent in the periodontal pocket of subject such that the therapeutic agent is released in a sustained manner. The glyceride composition is selected such that the mixture of the glyceride composition and the therapeutic agent is capable of forming a gel in the environment of the periodontal pocket. Also described is a sustained release delivery system comprising the mixture of the glyceride composition and therapeutic agent.

Abstract: An antimicrobial wound dressing and method of wound treatment, the wound dressing having a layer of a collagen dressing material impregnated with lyophilized, stabilized chlorine-containing compounds which generate on activation chlorine dioxide, like a mixture of sodium chlorate and sodium chlorite, and an adjacent layer secured thereto containing a dry, activating amount of an acidic compound, such as citric acid, whereby moisture from the wound activates the dry chlorine moiety to treat the wound.

Abstract: Provided by the invention are methods and compositions for increasing the growth rate and feed efficiency of turkeys by administration of an effective amount of the intermediate synthesis compound 19-nortestosterone. It has also been found that the invention provides increased muscle mass in the resulting turkey carcasses with a decreased percentage of fat mass and substantially no increase in skeletal growth over that of control turkeys.

Abstract: A patch for visceral surgery is made from a biomaterial consisting of two layers of collagen superimposed and closely combined, namely a porous adhesive layer of fibrous collagen and a film of collagen and/or gelatin.

Abstract: A laminated composite for administering fentanyl transdermally that consists of a fentanyl-impermeable occlusive backing layer and an adhesive fentanyl reservoir layer comprising fentanyl dissolved in an amine-resistant polydimethylsiloxane that has a high diffusivity and poor solubility for fentanyl which enables the fentanyl to be released rapidly from the composite over a one day period with little residual fentanyl left in the reservoir thereafter.

Abstract: Disclosed is a method of treating a skin lesion comprising applying to the lesion a dry bandage comprising a gas- and moisture-permeable, flexible, thermoplastic film impregnated with a pharmaceutical.

Abstract: The present invention relates to a plaster used as therapeutic system for the administration of active substances to the skin exhibiting an graduated active substance release, to the process for the production of such a plaster, and to the use for the local or systemic dermal adminstration of active substances in the human or veterinary medicine, or in cosmetics.

Abstract: The invention relates to a wound secretion absorbing hydrogel of the following composition:a) 20 to 70%-wt of at least one multivalent alcoholb) 10 to 35%-wt of at least one natural thickener (biopolymer)c) 0.05 to 12%-wt of at least one uncross-linked copolymer of one or more vinylcarboxylic acids and their salts (synthetic polymer)d) 0.05 to 10%-wt of a cross-linking agente) 0 to 50%-wt of water or physiological salineas well as to the use of this hydrogel as wound dressing.

Abstract: Oxidized cellulose material is neutralized, by contacting an acidic oxidized cellulose material with a water and alcohol solution of a basic salt of a weak organic acid, e.g. sodium acetate, to elevate the pH of the cellulosic material to between 5 and 8. The resulting neutralized product is storage stable and has therapeutic applications, including hemostasis and adhesion prevention. Furthermore, the neutralized product may be impregnated with acid-sensitive hemostatic agents, such as thrombin, to enhance its hemostatic properties, or with acid-sensitive adhesion-preventive agents, such as t-PA, to enhace its adhesion-prevention properties.

Abstract: A chemically crosslinked hydrogel includes an active ingredient for transdermal transport selected from the group of lidocainehydrochloride, hydrocortisone, menthol, and methyl salicylate and utilizes as a crosslinking agent an aluminum acetate, which is a polyvalent salt, which renders the resulting hydrogel electrically conductive with a resistance of less than 10,000 ohms per linear centimeter.

Abstract: An antimicrobial wound dressing and method of wound treatment, the wound dressing having a layer of a collagen dressing material impregnated with lyophilized, stabilized chlorine-containing compounds which generate on activation chlorine dioxide, like a mixture of sodium chlorate and sodium chlorite, and an adjacent layer secured thereto containing a dry, activating amount of an acidic compound, such as citric acid, whereby moisture from the wound activates the dry chlorine moiety to treat the wound.

Abstract: An antimicrobial wound dressing and method of wound treatment, the wound dressing having a layer of a collagen dressing material impregnated with lyophilized, stabilized chlorine-containing compounds which generate on activation chlorine dioxide, like a mixture of sodium chlorate and sodium chlorite, and an adjacent layer secured thereto containing a dry, activating amount of an acidic compound, such as citric acid, whereby moisture from the wound activates the dry chlorine moiety to treat the wound.

Abstract: A coating material for medical care having anti-bacterial action against Psuedomonas aeruginosa, Staphylococcus aureus, Escherichia coli and fungus is disclosed.Powdered zeolite, wherein one or the whole of metals contained in said zeolite is substituted by at least one kind of ion exchangeable metal selected from the group consisting of Ag, Cu and Zn, is coated onto the coating material made of silicone rubber etc or kneaded thereinto.

Abstract: A method for treating alcoholism by extinguishing the alcohol-drinking response in which an opiate antagonist is transdermally administered to a subject and a device for transdermally administering the antagonist. The device is a package containing a fixed dose of opiate antagonist, a vehicle and a permeation enhancer.

Abstract: A method for preventing adhesion between vital tissues includes the step of placing between the tissues a material made up of biodegradable derivatives of chitin which are soluble in aqueous solutions containing dilute acids such as acetic acid. This material has the advantage of requiring no reoperation for its removal since it would be degraded and absorbed after completing its function in vivo. These materials may be in the form of a visco-elastic fluid, a gel, a film or a membrane.

Abstract: An ibuprofen containing hydroalcoholic gel of pH 3.5 to 6.0 for topically treating inflammation or pain comprising an effective amount of ibuprofen; 40 to 60% alcohol, e.g. ethanol or isopropyl alcohol; 0-20% of a non-volatile solvent, e.g. propylene glycol; 2.0 to 5.0% gelling agents, e.g. 2.5% hydroxypropyl cellulose or 4.0% polyacrylic acid polymer; sufficient base, e.g. triethanolamine, to adjust the pH to between 3.5 and 6.0; and water; methods for delivering ibuprofen through the skin to treat inflammation or pain using the hydroalcoholic gel; and use of substantially pure S-ibuprofen to topically treat such inflammation or pain.

Abstract: The invention relates to biodegradable poly((hydroxyalkyl)amino dicarboxylic acid) derivatives of the formula I ##STR1## in which n, m, x, y, z, R and R' have the indicated meanings, and to a process for their preparation and to the use thereof for depot formulations with controlled delivery of active ingredient.

Abstract: The invention relates to a transdermal therapeutic system in the form of a multilayer plaster for the administration of active substances which are able to permeate, in the form of a matrix system containing at least three layers:(a) a covering layer which is impermeable for the constituents of the reservoir b);(b) a reservoir layer which is able to deliver active substance and which consists of optionally crosslinked block copolymer based on styrene, alkadienes and optionally alkenes mixed with adhesive polymers and is optionally provided with an additional adhesive membrane layer and contains at least one active substance capable of skin permeation, at least one agent promoting the skin permeability of active substances and optionally further pharmaceutical auxiliaries, and(c) a protective film which can be pulled off the reservoir layer.

Abstract: Floss spun from a mixture of a saccharide and an oleaginous substance which includes a medicament distributed on or through the fibers is compacted and chopped by passing through a conventional "food grinder" or equivalent having an auger feed to a cutter and orifice plate outlet. The enclosed volume of the end product is less than 30% and preferably less than 15% of the as-spun volume of the floss. This volume reduction is accomplished without distroying the colloidal-like behavior of the product. The compressed particles are readily metered for producing dosage units within required tolerances.

Abstract: A sustained release pharmaceutical preparation for percutaenous administration use mainly composed of a drug layer which is a layer made to contain drugs, to have no adhesiveness to the skin, but to be used in contact with the skin.

Abstract: Collagen implants that are useful as wound healing matrices are characterized by being formed of collagen fibrils that are not chemically cross-linked, and having a bulk density of 0.01 to 0.3 g/cm.sup.3 and a pore population in which at least about 80% of the pores have an average pore size of 35 to 250 microns. The implants are capable of promoting connective tissue deposition, angiogenesis, reepithelialization, and fibroplasia. The wound healing matrix also serves an an effective sustained delivery system for synergistic combinations of FGF and TGF-B.

Abstract: A percutaneous absorption accelerator and a percutaneous absorbent preparation containing the same and, more particularly, a percutaneous absorption accelerator containing either derivatives of specific glycerols or polyglycerols and alcohols as effective components and a percutaneous absorbent preparation containing the percutaneous absorption accelerators and pharmaceutically effective components.

Abstract: Delivery systems containing at least one aminopolysaccharide derivative are provided for the delivery of pharmaceutical or therapeutic actives to a desired topical or mucous membrane site in a subject, and wherein upon delivery, the systems provides a biocompatible, substantive, gas permeable, film from which actives are available at the designated site.

Abstract: Heterogeneous acid decrystallization of aminopolysaccharides, especially chitosen, using diluent, organic acid and water, provides novel salts and covalent derivatives useful in diverse applications including biomedicine, personal care and fluid separation.

Abstract: The invention relates to biodegradable poly((hydroxyalkyl)amino dicarboxylic acid) derivatives of the formula I ##STR1## in which n, m, x, y, z, R and R' have the indicated meanings, and to a process for their preparation and to the use thereof for depot formulations with controlled delivery of active ingredient.

Abstract: Therapeutic agent delivery devices and methods for using them in treatment of dental disease are disclosed. In the treatment of periodontal disease, a therapeutic agent such as tetracycline mixed in a polymeric matrix such as ethylene vinyl acetate copolymer is packed into the area to be treated and kept in place for a suitable time, during which the therapeutic agent diffuses out of the polymeric matrix, providing continuous therapy for the treatment site.

Abstract: An artificial skin or bandage is formed from an elastomeric layer which is surfaced by a fibrous wound contacting layer which is first formed into a fabric and subsequently degraded by heat hydrolysis or other degradative treatment into a form which could no longer be formed into a fabric but which forms an ideal bioabsorbable wound contact surface in which damage to the newly formed, fragile epidermus is minimized.

Abstract: The healing of a surface wound is promoted by contacting the wound surfaces with a suspension of particles of collagen and a glycosaminoglycan that is chemotactic of fibroblasts and/or endothelial cells. Typical glycosaminoglycans that exhibit the desired chemotaxis are heparin, heparan sulfate, and alginate. Two or more glycosaminoglycans can be present in the suspensions. Collagen and glycosaminoglycan are present as a dry powdered suspension of particles. Preferably, collagen is present in the suspension in the order of 7-10 mg/ml; while the glycosaminoglycan is present in much lower concentrations, e.g., 250-350 .mu.g/ml. Application of the collagen/glycosaminoglycan suspension to open wounds greatly increases the rate of healing.The invention includes, an article, useful in the therapy for surface wounds, comprising the suspension of particles on a gauze, bandage tape or the like.

Abstract: The instant invention is directed to a drug delivery device for the controlled release of beneficial agents and drugs into an environment of use comprising:(A) a core composition comprising(a) a water insoluble, non-diffusible charged resin entity, and(b) a diffusible, water soluble ionizable therapeutically active ingredient carrying the same charge as said resin entity; and(B) a substantially imperforate water-insoluble wall surrounding said core composition, prepared from a semipermeable material substantially impermeable to the core composition and permeable to the passage of an external fluid in the environment of use, with said wall having a hole(s) for release of the therapeutic agent through the water insoluble wall.

Abstract: A composition for the transmembranal, including transdermal administration of a pharmaceutical preparation comprising medical grade dimethylsiloxane, a catalyst capable of forming an elastomer, a permeation enhancer and a biologically active material, as well as a device for administering the aforementioned compositions and also a method for administering transdermally to a mammal an effective amount of the aforementioned compositions is herein described.

Abstract: An automatic drug tape dispensing and metering device and a roll of drug tape housed in a small portable dispenser unit. The dispenser contains a measurement device for carefully measuring the length of tape as it is dispensed from the dispenser. A counter monitors the remaining doses of drug tape remaining within the dispenser. A timer device may be provided to alert the patient that it is time for the medicament to be dispensed. As the lid of the dispenser unit is opened, the measured length of drug tape is severed from the roll by a cutter blade incorporated into the lid. The device permits a physician to accurately customize the dosage and administration of the medicament to be given a patient by adjusting the tape length released for each single dose and selecting the time intervals between dosages.

Abstract: A device for the controlled release and delivery of a pharmacologically active agent, comprising a vinyl gel layer and a pharmacologically active agent uniformly dispersed in the layer in a pharmacologically effective amount, the vinyl layer comprising a polyvinyl chloride resin, a primary plasticizer for the polyvinyl chloride resin, and an organic, nonvolatile gel forming additive in an amount sufficient to form a gel.

Abstract: The administration of a bronchodilator to a subject can be carried out using a new transdermal delivery system, a multilayer laminate where the drug is mixed in a gel which must pass through a barrier membrane prior to administration on the skin.

Abstract: Therapeutic agent delivery devices and methods for using them in treatment of dental disease are disclosed. In the treatment of periodontal disease, a therapeutic agent such as tetracycline mixed in a polymeric matrix such as ethylene vinyl acetate copolymer is packed into the area to be treated and kept in place for a suitable time, during which the therapeutic agent diffuses out of the polymeric matrix, providing continuous therapy for the treatment site.

Abstract: The invention relates to a process for preparing antispasmatic products which are to be attached to the skin. One or more kinds of metal or metallic substances and/or deficiency and/or trace elements and in a given case the active ingredients of some known pharmaceutical agent is applied to a carrier. The deficiency and/or trace element and in a given case the active ingredient of the known pharmaceutical agent medicament, which are present, are applied in form of a powder, a liquid or in gaseous form. The powdered, liquid and gaseous substances are placed into a recipient, e.g. bag with a permeable wall onto the carrier. Preferably, adhesive strips are provided on the margins of the carrier, while the substances on the carrier are covered with a removable protective layer. If required, the carrier is pretreated with a weak base or acid prior to the application thereof.