Web, Sheet Or Filament Bases; Compositions Of Bandages; Or Dressings With Incorporated Medicaments Patents (Class 424/443)
  • Patent number: 11672646
    Abstract: A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.
    Type: Grant
    Filed: September 13, 2021
    Date of Patent: June 13, 2023
    Assignee: Biorez, Inc.
    Inventors: Kevin A. Rocco, Bhavana Mohanraj, Jeffrey Ott, Justin Bendigo, Jacob Edward Komenda, Mark Theodore Aronson, Andrew James Carter
  • Patent number: 11672778
    Abstract: There is provided a plastic material comprising at least one cannabinoid embedded within a structural polymer, wherein the plastic material is formulated to exude the at least one cannabinoid through an outer surface of the plastic material at a therapeutically effective rate for a period of at least a week or at least a month. The plastic material may comprise a liquid-absorbent material embedded within the structural polymer and a carrier oil absorbed into the liquid-absorbent material, wherein at least one cannabinoid is dissolved in the carrier oil.
    Type: Grant
    Filed: July 13, 2022
    Date of Patent: June 13, 2023
    Inventors: Amnon Vardi, Nimrod Vardi, Omer Vardi
  • Patent number: 11654089
    Abstract: Water-soluble cleansing wipes or pads comprising a water-soluble support and their uses in the cosmetic field for cleansing of the skin are disclosed.
    Type: Grant
    Filed: August 5, 2020
    Date of Patent: May 23, 2023
    Assignee: L'OREAL
    Inventors: Michael Robinson, Jean-Pascal Hirt, William Bickford
  • Patent number: 11642506
    Abstract: Provided is a microneedle patch comprising a substrate part and multiple needle parts protruding from the substrate part. The substrate part consists of a diffusion-proof layer and a base, and each needle part consists of a needle tip, a diffusion-proof layer and a base. The diffusion-proof layer of each needle part is formed between the needle tip and the base of the corresponding needle part. The diffusion-proof layer of the substrate part and the diffusion-proof layer of needle part are one-piece structures, and so are the base of the substrate part and the base of the needle part. The diffusion-proof layer of the microneedle patch can prevent the active ingredients from diffusing to the base, limit the active ingredients to the needle tip and control the carrying quantity thereof.
    Type: Grant
    Filed: January 11, 2022
    Date of Patent: May 9, 2023
    Assignee: Win Coat Corporation
    Inventors: Ta-Jo Liu, Wan-Hua Li, Han-Yin Cheng, Yi-Jyun Liao, Wen-Hsu Lien, Shin-Yi Yin, Ying-Hua Hsu, Hsiu-Feng Yeh
  • Patent number: 11638720
    Abstract: The present invention pertains to quantum-scale biocidal particles and chemical reactions that disrupt and eviscerate microbial matter by combining aqueous and dry components. As halo-fullerene activation requires volatile excitation to mix, contact and collide so as to rupture microbial matter, atomic scale chemical reactions impart the requisite movement of engineered halo-fullerenes to destroy bacterial, fungal and viral matter upon contact. The present invention includes two primary mechanisms: an excitation chemistry and biocidal, hydrophobic halo-fullerenes. Upon aqueous exposure, the dry composition initiates a chemical reaction that activates biocidal halo-fullerenes to disrupt biologic surfaces in topical applications. The object of the present invention is a shelf stable, pre-packaged wiping material or dry packet for rehydration with broad spectrum antimicrobial activity.
    Type: Grant
    Filed: October 26, 2022
    Date of Patent: May 2, 2023
    Inventors: Terry Earl Brady, Anthony Lee Dellinger, Lowell Hughes, Melinda K. M. Goddard, Julie Catherine-Elise Hakim
  • Patent number: 11633477
    Abstract: The present invention provides a technique for treating the cornea. More specifically, the present invention is an agent for the treatment or prevention of a state of corneal endothelial disease, the agent including at least one factor selected from the group consisting of laminin and fragments thereof, wherein the problem is solved by also providing a technique characterized in that this agent is administered together with corneal endothelial cells. Specifically, the present invention can include laminin 511 (?5?1?1), laminin 521 (?5?2?1), or a fragment of these.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: April 25, 2023
    Assignees: KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, THE DOSHISHA, SENJU PHARMACEUTICAL CO., LTD.
    Inventors: Noriko Koizumi, Naoki Okumura, Shigeru Kinoshita
  • Patent number: 11633938
    Abstract: The invention relates to a multi-layered fabric comprising an absorption layer between two liquid-permeable layers, which multi-layered fabric has a surface with: 1) one or more connection areas wherein a connection is present between both layers; and 2) one or more absorption areas wherein both layers are not connected to each other. The absorption areas are capable of absorbing a liquid whereby the liquid is absorbed by the absorption layer. The connection between the layer L1 and the layer L2 comprises a fusion of the layer L1 and the layer L2, which fusion optionally also includes the absorption layer.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: April 25, 2023
    Assignee: TIESNITSCH BEHEER B.V.
    Inventors: Johannes Ijsbrand Tienitsch, Lieven Valeer Karel Bekaert
  • Patent number: 11633367
    Abstract: A transdermal therapeutic system containing rotigotine base in a self-adhesive layer structure. The system includes a backing layer, and a rotigotine-containing biphasic layer. The biphasic layer has an outer phase having a composition including 75% to 100% of a polymer or a polymer mixture, and an inner phase that forms dispersed deposits in the outer phase. The inner phase includes rotigotine base and a polymer mixture of at least two hydrophilic polymers. The hydrophilic polymers are selected from the group of polyvinylpyrrolidones having a K-Value of at least 80, polyvinylpyrrolidones having a K-Value of less than 80, copolymers of vinyl caprolactam, vinylacetate and ethylene glycol, copolymers of vinylpyrrolidone and vinylacetate, copolymers of ethylene and vinylacetate, polyethylene glycols, polypropylene glycols, acrylic polymers, and modified celluloses. The polymer mixture in the inner phase is present in an amount sufficient so that it forms a solid solution with the rotigotine base.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: April 25, 2023
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Marco Emgenbroich, Elke Klein, Heike Kluth
  • Patent number: 11602504
    Abstract: Disclosed is a description and methods for formulating oral films containing lipophilic active ingredient(s), more particularly lipophilic active having a positive log P. The method involves dispersing the lipophilic active(s) in a carrier oil and uniformly distributing them as emulsified oil droplets into a polymer matrix. The methods reported here produce oral films containing a stable emulsion with up to 40% oil phase. The oil phase consists of the carrier oil and lipophilic active(s). This offers the possibility to enhance the amount of lipophilic actives to be included in the film formulation while preserving the film characteristics. The resulting oral films offer a standardized dosage form for lipophilic actives as well as easier and more convenient administration, transportation, handling, and storage.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: March 14, 2023
    Assignee: INTELGENX CORP.
    Inventors: Carolin Madwar, Nadine Paiement, Rodolphe Obeid, Justin Conway, Erick Gonzalez-Labrada
  • Patent number: 11596708
    Abstract: A medical polymer device comprising a biodegradable polymer is provided, wherein the biodegradable polymer has a crystallinity of about 10% to about 80%, and preferably from about 20% to about 60%, wherein the medical polymer device comprises a small molecule organic compound which diffuses into the biodegradable polymer, the small molecule organic compound has a molecular weight of from about 100 to about 1000 Daltons, preferably from about 150 to about 500 Daltons, and more preferably from about 150 to about 250 Daltons, and the small molecule organic compound is non-evaporating or low-evaporating. The present invention also provides a method for preparing a medical polymer device according to the present invention as well as a method for modifying a medical polymer device made from a biodegradable polymer.
    Type: Grant
    Filed: February 3, 2021
    Date of Patent: March 7, 2023
    Assignee: Beijing Advanced Medical Technologies, Ltd. Inc.
    Inventors: Hugh Qinghong Zhao, Qing Liu, Hanqing Feng, Guixin Shi, Dengqiang Jia
  • Patent number: 11590106
    Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent sustained-release properties while enhancing skin permeability by using a silicone-based pressure-sensitive adhesive base. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, a silicone-based pressure-sensitive adhesive base and a release control agent, and the ratio of the maximum skin permeation rate of asenapine to the minimum skin permeation rate from the time when the maximum skin permeation rate is reached to 24 hours is less than 1.62.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: February 28, 2023
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Masaki Yukuhiro, Yuka Takagi, Yasunari Michinaka
  • Patent number: 11571494
    Abstract: A method, material, and kit for promoting neutrophils and monocytes to localize at a chronic ulcer site, promoting formation of a multi-layered cell structure in the ulcer site, promoting conversion of monocytes to macrophages, promoting secretion of the patient's own growth factors, promoting tissue proliferation and cell migration, promoting production and cross-linking of collagen at the chronic ulcer site, promoting growth of endothelial cells, promoting angiogenesis that was stalled at the chronic ulcer site, promoting formation of a vascular network and granulation, promoting oxygenation of the chronic ulcer site, and reducing one or more of purulent drainage, erythema, pain, warming, tenderness, induration, and bleeding at the chronic ulcer site.
    Type: Grant
    Filed: December 16, 2020
    Date of Patent: February 7, 2023
    Assignees: Geistlich Pharma AG, University of Southern California
    Inventors: Charles Zelen, David G. Armstrong, Paul Glat, Jarrod Kaufman, Marco Mehr, Lothar Schloesser, Mark Spilker
  • Patent number: 11565027
    Abstract: A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: January 31, 2023
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Christine E. Schmidt, Scott A. Zawko, Sarah M. Mayes
  • Patent number: 11547568
    Abstract: An implant for treating a bone defect wherein the implant comprises osteoconductive supporting bodies and an insertion aid. The insertion aid is designed for insertion of the osteoconductive supporting bodies into a bone defect and for holding together the osteoconductive supporting bodies. Also disclosed is a kit comprised of an implant for treating a bone defect.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: January 10, 2023
    Assignee: AESCULAP AG
    Inventors: Wolfgang Abele, Georg Hettich, Silke Koenig
  • Patent number: 11511018
    Abstract: A method for preparing a conductive biomimetic skin scaffold material with self-repairing function includes the following steps: adding 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride to a homogeneous dispersion of acidified carbon nanotubes, poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), and gelatin to cross-link to obtain a conductive composite colloid; and injecting the conductive composite colloid into a mold, aging at ?4-4° C. for 12-24 hours, and then soaking in a phosphate-buffered saline (PBS) solution with a pH of 7.0-7.4 for 12-24 hours to obtain the conductive biomimetic skin scaffold material.
    Type: Grant
    Filed: March 16, 2021
    Date of Patent: November 29, 2022
    Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Xuechuan Wang, Manhui Zheng, Xinhua Liu, Ouyang Yue, Mengdi Hou, Youyou Wang
  • Patent number: 11492380
    Abstract: Described are methods, compositions, and devices for a concatemeric protein standard that behaves as a protein but transforms into single peptides upon digestion, which is optimized to function as a non-obtrusive process control for mass spectrometry analysis.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: November 8, 2022
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Mathew Gerald Lyman, Deon S. Anex, Bonnee Rubinfeld
  • Patent number: 11486058
    Abstract: Thermally stable absorbable fiber populations, i.e. fiber populations that do not undergo thermally induced crystallization, can be intermixed with thermally unstable fibers to yield a stabilizing effect without altering morphological properties of a fiber system. Via this, one may minimize thermally induced shrinkage and maintain physical properties of electrospun materials in the as-formed state.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: November 1, 2022
    Assignee: Poly-Med, Inc.
    Inventors: Michael Scott Taylor, Seth Dylan McCullen
  • Patent number: 11478439
    Abstract: Improved methods and compositions are disclosed for treating dry eye by administering intranasally a therapeutically effective amount of a capsaicinoid compound embedded in multiple layers of solid lamellar crystals of monoglycerides to patients with deficient tear production. The lipophilic capsaicinoid drug is embedded in multiple layers of solid lamellar crystals of monoglycerides, and these crystals are incorporated into pharmaceutically acceptable vehicles comprised of solutions, suspensions, foams, creams, ointments, and gels. The resulting formulations of the capsaicinoid are suitable for application to the nasal mucosa or skin and are more stable, less irritating to skin and mucous membranes, and provide increased and more controlled release of the capsaicinoid compound.
    Type: Grant
    Filed: October 8, 2021
    Date of Patent: October 25, 2022
    Assignee: Elorac, Inc.
    Inventor: Joel E. Bernstein
  • Patent number: 11478422
    Abstract: Disclosed herein is a self-supporting, dissolvable, film containing dexmedetomidine or a pharmaceutically acceptable salt thereof. The film is administered orally to treat various conditions, particularly agitation, by transmucosal delivery of the active agent.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: October 25, 2022
    Assignees: BioXcel Therapeutics, Inc., ARx, LLC
    Inventors: Vasukumar Kakumanu, David Christian Hanley, Frank Yocca, Chetan Dalpatbhai Lathia, Scott David Barnhart
  • Patent number: 11471406
    Abstract: An oral film dosage form includes a high viscosity polymer in an amount of from 1% to 5% by dry weight to reduce, modulate and/or control Cmax of an active agent. The high viscosity polymer has a viscosity of from 100 cps to 500 cps as determined at 2% concentration in water by weight at 25° C. using a Brookfield LVF viscometer with spindle no. 2 at 60 rpm.
    Type: Grant
    Filed: October 5, 2020
    Date of Patent: October 18, 2022
    Assignee: INTELGENX CORP.
    Inventors: Nadine Paiement, Rodolphe Obeid, Justin Conway, Billal Tir
  • Patent number: 11471555
    Abstract: Absorbent materials configured to sequester trimethylamine (TMA), absorbent articles made therefrom, related methods of use, methods of measuring a reduction of free TMA, and related methods of making absorbent articles are described.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: October 18, 2022
    Assignee: INTERNATIONAL PAPER COMPANY
    Inventors: Mary Virginia Schoolfield, Hugh West
  • Patent number: 11471332
    Abstract: A dressing for treating a tissue site with negative pressure includes a manifold having a first surface and a second surface opposite the first surface. The dressing also includes a first layer adjacent to the first surface and a second layer adjacent to the second surface. The first layer and the second layer each include a polymer film. The dressing also includes a plurality of fluid restrictions in the polymer film adjacent to at least the first surface, and a plurality of bonds between the first layer and the second layer. The plurality of bonds defines separable sections of the manifold.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: October 18, 2022
    Assignee: KCI Licensing, Inc.
    Inventors: Christopher Brian Locke, Timothy Mark Robinson, David George Whyte
  • Patent number: 11464736
    Abstract: Orodispersible films (ODFs) and methods for making the same.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: October 11, 2022
    Assignee: UNM Rainforest Innovations
    Inventor: Jason Thomas McConville
  • Patent number: 11459699
    Abstract: An antibacterial leather uses the organic silica gel as the main component, uses the carboxymethyl chitosan silver as the antibacterial factor, and uses the modified nano-silica and the modified layered double oxide as the flame retardant factor. The synergistic effects between the components, such as the good binding between carboxymethyl chitosan silver and the substrate, the synergistic flame retardant effect between flame retardant factors, the bonding effect between modified nano-silica and dimethicone, and the synergistic effect between the high-viscosity dimethicone and the low-viscosity dimethicone are utilized to improve the process, thereby obtaining a good antibacterial, flame retardant and other properties, meanwhile meeting the requirement for the material mechanical properties and environmental protection.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: October 4, 2022
    Assignee: XIAMEN XIN DE LI INVESTMENT & DEVELOPMENT CO., LTD.
    Inventors: Liguo Yang, Ziqiao Liu, Siyong Chen
  • Patent number: 11441261
    Abstract: The invention provides fabrics that incorporate protease enzymes that inactivate viruses and bacteria. The fabrics of the invention may be used in the production of various items of self-sterilizing protective equipment including protective facemasks.
    Type: Grant
    Filed: September 6, 2021
    Date of Patent: September 13, 2022
    Assignee: WABESO Enhanced Enzymatics, Inc.
    Inventor: Mandy Jane Ward
  • Patent number: 11426442
    Abstract: Compositions and methods for skincare treatment are provided. The invention relates more generally to skin care treatment and more particularly, to compositions and methods for promoting healthy skin, skin regeneration, skin repair, skin bed preparation, and enhanced wound healing.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: August 30, 2022
    Assignee: ALASTIN SKINCARE, INC.
    Inventors: John A. Garruto, Alan David Widgerow
  • Patent number: 11414574
    Abstract: A compostable biopolymer adhesive may include a starch, a hydroxylic liquid, a preservative mixture, a crystallization inhibitor, and a carbonate, wherein the compostable biopolymer may be free of synthetic materials yet has a long shelf life, is stable at room temperature, and which can be used to make slime for play. The preservative mixture may include a mixture of saccharides and salt, and the salt may make up about 10 to about 90 wt. % of the dry materials used to make the compostable biopolymer adhesive.
    Type: Grant
    Filed: November 9, 2020
    Date of Patent: August 16, 2022
    Inventor: Ana Maria Visinoni-Davidov
  • Patent number: 11406607
    Abstract: Compositions for treatment of cystinosis, products for administering eye drops, and products for storing contact lenses are provided. Compositions include solutions that can contain an effective amount of cysteamine to treat cystinosis, and an oil with a lower density than the solution. Also provided is a product including a bottle for containing a solution, the bottle being substantially free of O2. Also provided is a contact lens holder for storing one or more contact lenses in a solution, the holder including barrier layers reducing the amount of O2 entering the contact lens holder.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: August 9, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Anuj Chauhan, Phillip J. Dixon
  • Patent number: 11406945
    Abstract: A device or system includes a mixer comprising a three-dimensional lattice defining a plurality of tortuous, interconnecting passages therethrough. The mixer is in communication with sources or streams of at least two separate components which, when mixed, form a combined fluid stream. The sources or streams may be, at least initially, on opposite sides of the mixer, or the sources or streams may be on the upstream side of the mixer with an outlet disposed downstream of the mixer. A related method may include providing a mixer comprising a three-dimensional lattice defining a plurality of tortuous, interconnecting passages therethrough, and selecting a material for the mixer based on physical characteristics of said material, said characteristics including a selected one or more of mean flow pore size, thickness and porosity volume.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: August 9, 2022
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventor: Yves A. Delmotte
  • Patent number: 11396148
    Abstract: A method for making an improved contact lens with the steps of providing a mold with a space between the top surface and a bottom surface, and positioning a mat in the space of the mold, providing a bead of liquid polymer of predetermined size at a predetermined location on the surface of the mat, pressing the bead of liquid polymer into the mat between the top surface and the bottom surface of the mold to form an optical zone framed by a mat peripheral zone, exposing the optical zone and the peripheral zone with U-V radiation to harden the optical zone into a composite improved contact lens, removing the cross-linked improved contact lens from the mold, processing the peripheral zone surrounding the optical zone to have a fenestration surface having holes, the holes being through holes with predetermined diameters selected to pass larger proteins, lipids, metabolites.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: July 26, 2022
    Inventor: Randall F. Fuerst
  • Patent number: 11389409
    Abstract: The present invention relates to transdermal devices comprising prodrugs of anti-pyretic, analgesic, or anti-inflammatory molecules, methods of making such devices, and methods of use thereof for treating, preventing, minimizing, and/or diminishing fever or pain.
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: July 19, 2022
    Assignee: REMEDY DIAGNOSTICS LLC
    Inventors: Lori Ramirez, Reza Amirzadeh, Opinya Ekabo
  • Patent number: 11389410
    Abstract: The present invention relates to a transdermal therapeutic system, comprising (a) a backing layer, (b) a solvent-based self-adhesive matrix layer containing rotigotine as active ingredient, and (c) a release liner, wherein the self-adhesive matrix layer has a coating weight of about 75-400 g/m2 and comprises a reservoir layer containing about 9-25 wt.-% rotigotine based on the weight of the reservoir layer, a kit comprising two transdermal therapeutic systems of the present invention as well as a method for the preparation of the transdermal therapeutic system of the present invention.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: July 19, 2022
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Willi Cawello, Aurelia Lappert, Kristina Kassner, Hans-Michael Wolff, Walter Müller, Johannes Josef Leonhard, Marco Emgenbroich
  • Patent number: 11389319
    Abstract: An ostomy barrier includes an inlet opening for receiving a stoma and a barrier adhesive including a plurality of thicker portions and a plurality of thinner portions. The plurality of thinner portions are configured and arranged to improve the flexibility of the ostomy barrier.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: July 19, 2022
    Assignee: Hollister Incorporated
    Inventors: Ronald S. Botten, Christina Augustyn, Russell J. Todd, Peter L. Visconti, Heather M. Budorick, Lynn Sacramento
  • Patent number: 11369615
    Abstract: A means for substantially improving mitochondrial dysfunction is provided. An aspect of the present invention relates to an agent for improving mitochondrial dysfunction, having a compound represented by the following formula, a stereoisomer or a salt thereof, or a solvate thereof, as an active ingredient. Another aspect of the present invention relates to a medicament or a pharmaceutical composition having the aforementioned compound, a stereoisomer or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, as an active ingredient, for use in preventing or treating a disease or symptom caused by mitochondrial dysfunction.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: June 28, 2022
    Assignees: JICHI MEDICAL UNIVERSITY, TOHOKU UNIVERSITY
    Inventors: Hitoshi Osaka, Takanori Yamagata, Eriko Jimbo, Akihiko Miyauchi, Takaaki Abe
  • Patent number: 11371014
    Abstract: The present disclosure provides compositions and methods for producing hydrogel matrix constructs. Methods of using hydrogel matrix constructs for tissue repair and regeneration and for the oxygenation of red blood cells are also disclosed.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: June 28, 2022
    Assignee: William Marsh Rice University
    Inventors: Jordan Miller, Anderson Ta, Bagrat Grigoryan
  • Patent number: 11364656
    Abstract: A method of forming particles for controlled guest agent release includes coextruding first and second polymer materials to form a multilayer polymer composite sheet comprising alternating first and second polymer layers, dividing the multilayer sheet into particles, immersing the particles in a solvent containing the guest agent such that the first layers swell and the guest agent is loaded into the swollen first layers.
    Type: Grant
    Filed: July 5, 2019
    Date of Patent: June 21, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Rigoberto Advincula, Pengfei Chao, Eric Baer
  • Patent number: 11338057
    Abstract: Implantable scaffolds made from biopolymer fibers. Biopolymer is dissolved in acid in a closed container made of materials inert to the acid and to the collagen to form a biopolymer solution. The solution is stirred, then centrifuged to degas it. The degassed solution is put into syringes on a holder. The number of syringes equals the number of fibers in the bundle. The syringes are mounted in a rotatable holder. Essentially equal quantities of degassed solution are extruded from the syringes to produce fibers, which are gathered and fed into a formation buffer bath. The fibers are kept taught after extrusion and dehydrated in a dehydrating solution in a dehydrating bath. The fibers are wound a collector to collect the bundle. Scaffolds then are made.
    Type: Grant
    Filed: May 24, 2021
    Date of Patent: May 24, 2022
    Assignee: Embody, LLC
    Inventors: Michael P. Francis, Stella Petrova, Nicholas Thayer
  • Patent number: 11338056
    Abstract: A method for supporting repair of soft tissue with biopolymer fibers. Biopolymer is dissolved in acid in a closed container made of materials inert to the acid and to the collagen to form a biopolymer solution. The solution is stirred, then centrifuged to degas it. The degassed solution is put into syringes on a holder. The number of syringes equals the number of fibers in the bundle. The syringes are mounted in a rotatable holder. Essentially equal quantities of degassed solution are extruded from the syringes to produce fibers, which are gathered and fed into a formation buffer bath. The fibers are kept taught after extrusion and dehydrated in a dehydrating solution in a dehydrating bath. The fibers are wound a collector to collect the bundle. The fibers are used to support repair of soft tissue.
    Type: Grant
    Filed: May 24, 2021
    Date of Patent: May 24, 2022
    Assignee: EMBODY, INC.
    Inventors: Michael P. Francis, Stella Petrova, Nicholas Thayer
  • Patent number: 11324851
    Abstract: Absorbent materials configured to sequester trimethylamine (TMA), absorbent articles made therefrom, related methods of use, methods of measuring a reduction of free TMA, and related methods of making absorbent articles are described.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: May 10, 2022
    Assignee: INTERNATIONAL PAPER COMPANY
    Inventors: Mary Virginia Schoolfield, Hugh West
  • Patent number: 11318095
    Abstract: The present invention provides a micelle comprising an anionic micelle and a protecting agent surrounding the anionic micelle, the anionic micelle being formed from, as a structural unit, an ingredient that has a functional group capable of being anionized under basic conditions and has anionic micelle-forming ability, the protecting agent protecting the anionic micelle. The present invention also provides a micelle comprising a cationic micelle and a protecting agent surrounding the cationic micelle, the cationic micelle being formed from, as a structural unit, an ingredient that has a functional group capable of being cationized under acidic conditions and has cationic micelle-forming ability, the protecting agent protecting the cationic micelle.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: May 3, 2022
    Assignee: TEIKA PHARMACEUTICAL CO., LTD.
    Inventor: Toru Okaki
  • Patent number: 11311494
    Abstract: A formulation of a discrete liquid patch for the treatment of cold sores or viral lesions, including a combination of the adhesive layer and an active compound/ingredient such as antiviral agents, and/or amino acids, and/or minerals/vitamins. The adhesive layer of the discrete patch is substantially free of hydrocolloid particles. The adhesive layer does not include any backing layer to maintain the compliance of the patch with a thickness ranging from 5 microns to 1,300 microns. Wherein, the discrete patch of the invention is configured to apply to a viral lesion to maintain in contact therewith for a time effective to substantially complete re-epithelialization of the lesion.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: April 26, 2022
    Inventor: Adam Mark Murday
  • Patent number: 11311495
    Abstract: A transdermal therapeutic system which is free of fibrous constituents, and a method for the production of such a transdermal therapeutic system A preparation containing active substance is applied by a printing method onto the pressure-sensitive adhesive layer of the transdermal therapeutic system.
    Type: Grant
    Filed: February 28, 2006
    Date of Patent: April 26, 2022
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Reinhold Meconi, Klaus Schumann
  • Patent number: 11286372
    Abstract: The disclosed concept relates to compositions and methods for the manufacture of electrically resistive, thermally conductive electrical switching apparatus. The composition includes a polymer component and a nanofiber component. The thermal conductivity of the nanofiber component is higher than the thermal conductivity of the polymer component such that the electrical switching apparatus which includes the composition of the disclosed concept has improved heat dissipation as compared to an electrical switching apparatus constructed of the polymer component in the absence of the nanofiber component. Further, the disclosed concept relates to methods of towering the internal temperature of an electrically resistive, thermally conductive electrical switching apparatus by forming the internals of the apparatus, e.g., circuit breakers, and/or the enclosure from the composition of the disclosed concept.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: March 29, 2022
    Assignee: EATON INTELLIGENT POWER LIMITED
    Inventors: James Gerard Maloney, Edward Ethber Lias, Jeffrey Scott Gibson
  • Patent number: 11278098
    Abstract: Encapsulated hair bands and methods for use are disclosed. An encapsulated hair band includes an encapsulated hair band, including: a horseshoe shaped hair band, having a proximal and distal end, the hair band including, flexible material capable of flexing outwardly whereby the proximal and distal ends may be displaced from an unbiased position to a biased position to fit about the wearer's head; a soft gel; and a cover, including two or more pieces, cooperating to form a cover, the two or more pieces fastened together so as to encapsulate said horseshoe shaped hair band and said soft gel, said soft gel encapsulated so that when the encapsulated hair band is placed upon the wearer's head, the soft gel is between the horseshoe shaped hair band and the cover.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: March 22, 2022
    Inventor: Virginia Claire Malkin
  • Patent number: 11266535
    Abstract: The present invention generally relates to dressings such as bandages or tapes having improved extensibility and conformability to human skin and joints.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: March 8, 2022
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Marisha Gogolowski, Carmine Rizzo
  • Patent number: 11266534
    Abstract: The present invention generally relates to dressings such as bandages or tapes having improved extensibility and conformability to human skin and joints.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: March 8, 2022
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Marisha Gogolowski, Carmine Rizzo
  • Patent number: 11266361
    Abstract: A method of in vivo monitoring the condition of an internal body repair in which an imageable, non-absorbable repair device having non-absorbable, particulate imaging material substantially uniformly dispersed therein has been surgically inserted, including: in vivo sensing of dimensional deformation of said repair device during the post-surgical healing process; comparing the sensed values with a previously developed correlation between said sensed values and the values at which failure occurs of comparable repair devices; wherein said sensed values relative to the repair device's failure values, considered in conjunction with the anticipated time for complete healing of said repair, provides information as to the condition of the repair.
    Type: Grant
    Filed: May 9, 2019
    Date of Patent: March 8, 2022
    Assignee: S. JACKSON, INC.
    Inventors: Janko Jackson, Stephen L. Jackson, Crayton G. Toney
  • Patent number: 11246756
    Abstract: Single layered nonwoven wound dressings containing (1) about 5% by weight to about 95% by weight (e.g., 5% to 95%) non-scoured, non-bleached greige cotton fibers, (2) about 5% by weight to about 95% by weight (e.g., 5% to 95%) bleached cotton fibers, and (3) about 5% by weight to about 60% by weight (e.g., 5% to 60%) hydrophobic fibers (e.g., polypropylene, nylon); all percentages adding up to 100 wt %. Also, multi-layered nonwoven wound dressings, containing (1) at least one inner layer containing (a) about 50% by weight to about 95% by weight (e.g., 50% to 95) non-scoured, non-bleached greige cotton fibers and (b) about 5% by weight to about 50% by weight (e.g., 5% to 50%) hydrophobic fibers, all percentages adding up to 100 wt %, and (2) at least one outer layer containing (a) about 5% by weight to about 95% by weight (e.g., 5% to 95%) non-scoured, non-bleached greige cotton fibers, (b) about 5% by weight to about 95% by weight (e.g.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: February 15, 2022
    Assignees: The United States of America, as represented by the Secretary of Agriculture, H & H Medical Corporation, T.J. Beall Company
    Inventors: Judson V. Edwards, Joseph Dacorta, Gary Lawson
  • Patent number: 11229726
    Abstract: In some embodiments, the present invention provides methods for making resorbable ear tubes including the steps of providing a silk fibroin solution, and forming a silk ear tube from the silk fibroin solution, wherein the silk ear tube is less than 2 mm in length and has an outer diameter of less than 1.5 mm, and wherein the silk ear tube is resorbable. In some embodiments, the present invention also provides methods for treating otitis media including the step of introducing a silk ear tube into the ear canal of a subject, wherein the silk ear tube is less than 2 mm in length and has an outer diameter of less than 1.5 mm, and wherein the silk ear tube is resorbed by the subject.
    Type: Grant
    Filed: April 1, 2021
    Date of Patent: January 25, 2022
    Assignees: Tufts University, Massachusetts Eye and Ear Infirmary, The General Hospital Corporation
    Inventors: David Kaplan, Michael Whalen, Christopher Hartnick
  • Patent number: 11225582
    Abstract: A water soluble polymer composition includes a water soluble polymer and a sugar and may be used as a support in additive manufacturing processes.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: January 18, 2022
    Assignee: Infinite Material Solutions, LLC
    Inventors: Philip Brunner, Gavriel DePrenger-Gottfried, Nathan Ockwig