Web, Sheet Or Filament Bases; Compositions Of Bandages; Or Dressings With Incorporated Medicaments Patents (Class 424/443)
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Patent number: 11672646Abstract: A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.Type: GrantFiled: September 13, 2021Date of Patent: June 13, 2023Assignee: Biorez, Inc.Inventors: Kevin A. Rocco, Bhavana Mohanraj, Jeffrey Ott, Justin Bendigo, Jacob Edward Komenda, Mark Theodore Aronson, Andrew James Carter
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Patent number: 11672778Abstract: There is provided a plastic material comprising at least one cannabinoid embedded within a structural polymer, wherein the plastic material is formulated to exude the at least one cannabinoid through an outer surface of the plastic material at a therapeutically effective rate for a period of at least a week or at least a month. The plastic material may comprise a liquid-absorbent material embedded within the structural polymer and a carrier oil absorbed into the liquid-absorbent material, wherein at least one cannabinoid is dissolved in the carrier oil.Type: GrantFiled: July 13, 2022Date of Patent: June 13, 2023Inventors: Amnon Vardi, Nimrod Vardi, Omer Vardi
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Patent number: 11654089Abstract: Water-soluble cleansing wipes or pads comprising a water-soluble support and their uses in the cosmetic field for cleansing of the skin are disclosed.Type: GrantFiled: August 5, 2020Date of Patent: May 23, 2023Assignee: L'OREALInventors: Michael Robinson, Jean-Pascal Hirt, William Bickford
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Patent number: 11642506Abstract: Provided is a microneedle patch comprising a substrate part and multiple needle parts protruding from the substrate part. The substrate part consists of a diffusion-proof layer and a base, and each needle part consists of a needle tip, a diffusion-proof layer and a base. The diffusion-proof layer of each needle part is formed between the needle tip and the base of the corresponding needle part. The diffusion-proof layer of the substrate part and the diffusion-proof layer of needle part are one-piece structures, and so are the base of the substrate part and the base of the needle part. The diffusion-proof layer of the microneedle patch can prevent the active ingredients from diffusing to the base, limit the active ingredients to the needle tip and control the carrying quantity thereof.Type: GrantFiled: January 11, 2022Date of Patent: May 9, 2023Assignee: Win Coat CorporationInventors: Ta-Jo Liu, Wan-Hua Li, Han-Yin Cheng, Yi-Jyun Liao, Wen-Hsu Lien, Shin-Yi Yin, Ying-Hua Hsu, Hsiu-Feng Yeh
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Patent number: 11638720Abstract: The present invention pertains to quantum-scale biocidal particles and chemical reactions that disrupt and eviscerate microbial matter by combining aqueous and dry components. As halo-fullerene activation requires volatile excitation to mix, contact and collide so as to rupture microbial matter, atomic scale chemical reactions impart the requisite movement of engineered halo-fullerenes to destroy bacterial, fungal and viral matter upon contact. The present invention includes two primary mechanisms: an excitation chemistry and biocidal, hydrophobic halo-fullerenes. Upon aqueous exposure, the dry composition initiates a chemical reaction that activates biocidal halo-fullerenes to disrupt biologic surfaces in topical applications. The object of the present invention is a shelf stable, pre-packaged wiping material or dry packet for rehydration with broad spectrum antimicrobial activity.Type: GrantFiled: October 26, 2022Date of Patent: May 2, 2023Inventors: Terry Earl Brady, Anthony Lee Dellinger, Lowell Hughes, Melinda K. M. Goddard, Julie Catherine-Elise Hakim
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Patent number: 11633477Abstract: The present invention provides a technique for treating the cornea. More specifically, the present invention is an agent for the treatment or prevention of a state of corneal endothelial disease, the agent including at least one factor selected from the group consisting of laminin and fragments thereof, wherein the problem is solved by also providing a technique characterized in that this agent is administered together with corneal endothelial cells. Specifically, the present invention can include laminin 511 (?5?1?1), laminin 521 (?5?2?1), or a fragment of these.Type: GrantFiled: October 30, 2015Date of Patent: April 25, 2023Assignees: KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, THE DOSHISHA, SENJU PHARMACEUTICAL CO., LTD.Inventors: Noriko Koizumi, Naoki Okumura, Shigeru Kinoshita
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Patent number: 11633938Abstract: The invention relates to a multi-layered fabric comprising an absorption layer between two liquid-permeable layers, which multi-layered fabric has a surface with: 1) one or more connection areas wherein a connection is present between both layers; and 2) one or more absorption areas wherein both layers are not connected to each other. The absorption areas are capable of absorbing a liquid whereby the liquid is absorbed by the absorption layer. The connection between the layer L1 and the layer L2 comprises a fusion of the layer L1 and the layer L2, which fusion optionally also includes the absorption layer.Type: GrantFiled: March 7, 2019Date of Patent: April 25, 2023Assignee: TIESNITSCH BEHEER B.V.Inventors: Johannes Ijsbrand Tienitsch, Lieven Valeer Karel Bekaert
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Patent number: 11633367Abstract: A transdermal therapeutic system containing rotigotine base in a self-adhesive layer structure. The system includes a backing layer, and a rotigotine-containing biphasic layer. The biphasic layer has an outer phase having a composition including 75% to 100% of a polymer or a polymer mixture, and an inner phase that forms dispersed deposits in the outer phase. The inner phase includes rotigotine base and a polymer mixture of at least two hydrophilic polymers. The hydrophilic polymers are selected from the group of polyvinylpyrrolidones having a K-Value of at least 80, polyvinylpyrrolidones having a K-Value of less than 80, copolymers of vinyl caprolactam, vinylacetate and ethylene glycol, copolymers of vinylpyrrolidone and vinylacetate, copolymers of ethylene and vinylacetate, polyethylene glycols, polypropylene glycols, acrylic polymers, and modified celluloses. The polymer mixture in the inner phase is present in an amount sufficient so that it forms a solid solution with the rotigotine base.Type: GrantFiled: May 20, 2015Date of Patent: April 25, 2023Assignee: LTS Lohmann Therapie-Systeme AGInventors: Marco Emgenbroich, Elke Klein, Heike Kluth
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Patent number: 11602504Abstract: Disclosed is a description and methods for formulating oral films containing lipophilic active ingredient(s), more particularly lipophilic active having a positive log P. The method involves dispersing the lipophilic active(s) in a carrier oil and uniformly distributing them as emulsified oil droplets into a polymer matrix. The methods reported here produce oral films containing a stable emulsion with up to 40% oil phase. The oil phase consists of the carrier oil and lipophilic active(s). This offers the possibility to enhance the amount of lipophilic actives to be included in the film formulation while preserving the film characteristics. The resulting oral films offer a standardized dosage form for lipophilic actives as well as easier and more convenient administration, transportation, handling, and storage.Type: GrantFiled: April 15, 2019Date of Patent: March 14, 2023Assignee: INTELGENX CORP.Inventors: Carolin Madwar, Nadine Paiement, Rodolphe Obeid, Justin Conway, Erick Gonzalez-Labrada
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Patent number: 11596708Abstract: A medical polymer device comprising a biodegradable polymer is provided, wherein the biodegradable polymer has a crystallinity of about 10% to about 80%, and preferably from about 20% to about 60%, wherein the medical polymer device comprises a small molecule organic compound which diffuses into the biodegradable polymer, the small molecule organic compound has a molecular weight of from about 100 to about 1000 Daltons, preferably from about 150 to about 500 Daltons, and more preferably from about 150 to about 250 Daltons, and the small molecule organic compound is non-evaporating or low-evaporating. The present invention also provides a method for preparing a medical polymer device according to the present invention as well as a method for modifying a medical polymer device made from a biodegradable polymer.Type: GrantFiled: February 3, 2021Date of Patent: March 7, 2023Assignee: Beijing Advanced Medical Technologies, Ltd. Inc.Inventors: Hugh Qinghong Zhao, Qing Liu, Hanqing Feng, Guixin Shi, Dengqiang Jia
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Patent number: 11590106Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent sustained-release properties while enhancing skin permeability by using a silicone-based pressure-sensitive adhesive base. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, a silicone-based pressure-sensitive adhesive base and a release control agent, and the ratio of the maximum skin permeation rate of asenapine to the minimum skin permeation rate from the time when the maximum skin permeation rate is reached to 24 hours is less than 1.62.Type: GrantFiled: September 25, 2019Date of Patent: February 28, 2023Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Masaki Yukuhiro, Yuka Takagi, Yasunari Michinaka
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Patent number: 11571494Abstract: A method, material, and kit for promoting neutrophils and monocytes to localize at a chronic ulcer site, promoting formation of a multi-layered cell structure in the ulcer site, promoting conversion of monocytes to macrophages, promoting secretion of the patient's own growth factors, promoting tissue proliferation and cell migration, promoting production and cross-linking of collagen at the chronic ulcer site, promoting growth of endothelial cells, promoting angiogenesis that was stalled at the chronic ulcer site, promoting formation of a vascular network and granulation, promoting oxygenation of the chronic ulcer site, and reducing one or more of purulent drainage, erythema, pain, warming, tenderness, induration, and bleeding at the chronic ulcer site.Type: GrantFiled: December 16, 2020Date of Patent: February 7, 2023Assignees: Geistlich Pharma AG, University of Southern CaliforniaInventors: Charles Zelen, David G. Armstrong, Paul Glat, Jarrod Kaufman, Marco Mehr, Lothar Schloesser, Mark Spilker
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Patent number: 11565027Abstract: A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier.Type: GrantFiled: November 19, 2020Date of Patent: January 31, 2023Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Christine E. Schmidt, Scott A. Zawko, Sarah M. Mayes
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Patent number: 11547568Abstract: An implant for treating a bone defect wherein the implant comprises osteoconductive supporting bodies and an insertion aid. The insertion aid is designed for insertion of the osteoconductive supporting bodies into a bone defect and for holding together the osteoconductive supporting bodies. Also disclosed is a kit comprised of an implant for treating a bone defect.Type: GrantFiled: November 15, 2017Date of Patent: January 10, 2023Assignee: AESCULAP AGInventors: Wolfgang Abele, Georg Hettich, Silke Koenig
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Patent number: 11511018Abstract: A method for preparing a conductive biomimetic skin scaffold material with self-repairing function includes the following steps: adding 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride to a homogeneous dispersion of acidified carbon nanotubes, poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), and gelatin to cross-link to obtain a conductive composite colloid; and injecting the conductive composite colloid into a mold, aging at ?4-4° C. for 12-24 hours, and then soaking in a phosphate-buffered saline (PBS) solution with a pH of 7.0-7.4 for 12-24 hours to obtain the conductive biomimetic skin scaffold material.Type: GrantFiled: March 16, 2021Date of Patent: November 29, 2022Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Xuechuan Wang, Manhui Zheng, Xinhua Liu, Ouyang Yue, Mengdi Hou, Youyou Wang
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Patent number: 11492380Abstract: Described are methods, compositions, and devices for a concatemeric protein standard that behaves as a protein but transforms into single peptides upon digestion, which is optimized to function as a non-obtrusive process control for mass spectrometry analysis.Type: GrantFiled: June 22, 2020Date of Patent: November 8, 2022Assignee: Lawrence Livermore National Security, LLCInventors: Mathew Gerald Lyman, Deon S. Anex, Bonnee Rubinfeld
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Patent number: 11486058Abstract: Thermally stable absorbable fiber populations, i.e. fiber populations that do not undergo thermally induced crystallization, can be intermixed with thermally unstable fibers to yield a stabilizing effect without altering morphological properties of a fiber system. Via this, one may minimize thermally induced shrinkage and maintain physical properties of electrospun materials in the as-formed state.Type: GrantFiled: March 19, 2020Date of Patent: November 1, 2022Assignee: Poly-Med, Inc.Inventors: Michael Scott Taylor, Seth Dylan McCullen
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Patent number: 11478439Abstract: Improved methods and compositions are disclosed for treating dry eye by administering intranasally a therapeutically effective amount of a capsaicinoid compound embedded in multiple layers of solid lamellar crystals of monoglycerides to patients with deficient tear production. The lipophilic capsaicinoid drug is embedded in multiple layers of solid lamellar crystals of monoglycerides, and these crystals are incorporated into pharmaceutically acceptable vehicles comprised of solutions, suspensions, foams, creams, ointments, and gels. The resulting formulations of the capsaicinoid are suitable for application to the nasal mucosa or skin and are more stable, less irritating to skin and mucous membranes, and provide increased and more controlled release of the capsaicinoid compound.Type: GrantFiled: October 8, 2021Date of Patent: October 25, 2022Assignee: Elorac, Inc.Inventor: Joel E. Bernstein
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Patent number: 11478422Abstract: Disclosed herein is a self-supporting, dissolvable, film containing dexmedetomidine or a pharmaceutically acceptable salt thereof. The film is administered orally to treat various conditions, particularly agitation, by transmucosal delivery of the active agent.Type: GrantFiled: July 17, 2020Date of Patent: October 25, 2022Assignees: BioXcel Therapeutics, Inc., ARx, LLCInventors: Vasukumar Kakumanu, David Christian Hanley, Frank Yocca, Chetan Dalpatbhai Lathia, Scott David Barnhart
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Patent number: 11471406Abstract: An oral film dosage form includes a high viscosity polymer in an amount of from 1% to 5% by dry weight to reduce, modulate and/or control Cmax of an active agent. The high viscosity polymer has a viscosity of from 100 cps to 500 cps as determined at 2% concentration in water by weight at 25° C. using a Brookfield LVF viscometer with spindle no. 2 at 60 rpm.Type: GrantFiled: October 5, 2020Date of Patent: October 18, 2022Assignee: INTELGENX CORP.Inventors: Nadine Paiement, Rodolphe Obeid, Justin Conway, Billal Tir
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Patent number: 11471555Abstract: Absorbent materials configured to sequester trimethylamine (TMA), absorbent articles made therefrom, related methods of use, methods of measuring a reduction of free TMA, and related methods of making absorbent articles are described.Type: GrantFiled: May 25, 2018Date of Patent: October 18, 2022Assignee: INTERNATIONAL PAPER COMPANYInventors: Mary Virginia Schoolfield, Hugh West
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Patent number: 11471332Abstract: A dressing for treating a tissue site with negative pressure includes a manifold having a first surface and a second surface opposite the first surface. The dressing also includes a first layer adjacent to the first surface and a second layer adjacent to the second surface. The first layer and the second layer each include a polymer film. The dressing also includes a plurality of fluid restrictions in the polymer film adjacent to at least the first surface, and a plurality of bonds between the first layer and the second layer. The plurality of bonds defines separable sections of the manifold.Type: GrantFiled: June 5, 2018Date of Patent: October 18, 2022Assignee: KCI Licensing, Inc.Inventors: Christopher Brian Locke, Timothy Mark Robinson, David George Whyte
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Patent number: 11464736Abstract: Orodispersible films (ODFs) and methods for making the same.Type: GrantFiled: July 23, 2020Date of Patent: October 11, 2022Assignee: UNM Rainforest InnovationsInventor: Jason Thomas McConville
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Patent number: 11459699Abstract: An antibacterial leather uses the organic silica gel as the main component, uses the carboxymethyl chitosan silver as the antibacterial factor, and uses the modified nano-silica and the modified layered double oxide as the flame retardant factor. The synergistic effects between the components, such as the good binding between carboxymethyl chitosan silver and the substrate, the synergistic flame retardant effect between flame retardant factors, the bonding effect between modified nano-silica and dimethicone, and the synergistic effect between the high-viscosity dimethicone and the low-viscosity dimethicone are utilized to improve the process, thereby obtaining a good antibacterial, flame retardant and other properties, meanwhile meeting the requirement for the material mechanical properties and environmental protection.Type: GrantFiled: August 28, 2019Date of Patent: October 4, 2022Assignee: XIAMEN XIN DE LI INVESTMENT & DEVELOPMENT CO., LTD.Inventors: Liguo Yang, Ziqiao Liu, Siyong Chen
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Patent number: 11441261Abstract: The invention provides fabrics that incorporate protease enzymes that inactivate viruses and bacteria. The fabrics of the invention may be used in the production of various items of self-sterilizing protective equipment including protective facemasks.Type: GrantFiled: September 6, 2021Date of Patent: September 13, 2022Assignee: WABESO Enhanced Enzymatics, Inc.Inventor: Mandy Jane Ward
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Patent number: 11426442Abstract: Compositions and methods for skincare treatment are provided. The invention relates more generally to skin care treatment and more particularly, to compositions and methods for promoting healthy skin, skin regeneration, skin repair, skin bed preparation, and enhanced wound healing.Type: GrantFiled: May 8, 2020Date of Patent: August 30, 2022Assignee: ALASTIN SKINCARE, INC.Inventors: John A. Garruto, Alan David Widgerow
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Patent number: 11414574Abstract: A compostable biopolymer adhesive may include a starch, a hydroxylic liquid, a preservative mixture, a crystallization inhibitor, and a carbonate, wherein the compostable biopolymer may be free of synthetic materials yet has a long shelf life, is stable at room temperature, and which can be used to make slime for play. The preservative mixture may include a mixture of saccharides and salt, and the salt may make up about 10 to about 90 wt. % of the dry materials used to make the compostable biopolymer adhesive.Type: GrantFiled: November 9, 2020Date of Patent: August 16, 2022Inventor: Ana Maria Visinoni-Davidov
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Patent number: 11406607Abstract: Compositions for treatment of cystinosis, products for administering eye drops, and products for storing contact lenses are provided. Compositions include solutions that can contain an effective amount of cysteamine to treat cystinosis, and an oil with a lower density than the solution. Also provided is a product including a bottle for containing a solution, the bottle being substantially free of O2. Also provided is a contact lens holder for storing one or more contact lenses in a solution, the holder including barrier layers reducing the amount of O2 entering the contact lens holder.Type: GrantFiled: May 21, 2019Date of Patent: August 9, 2022Assignee: University of Florida Research Foundation, Inc.Inventors: Anuj Chauhan, Phillip J. Dixon
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Patent number: 11406945Abstract: A device or system includes a mixer comprising a three-dimensional lattice defining a plurality of tortuous, interconnecting passages therethrough. The mixer is in communication with sources or streams of at least two separate components which, when mixed, form a combined fluid stream. The sources or streams may be, at least initially, on opposite sides of the mixer, or the sources or streams may be on the upstream side of the mixer with an outlet disposed downstream of the mixer. A related method may include providing a mixer comprising a three-dimensional lattice defining a plurality of tortuous, interconnecting passages therethrough, and selecting a material for the mixer based on physical characteristics of said material, said characteristics including a selected one or more of mean flow pore size, thickness and porosity volume.Type: GrantFiled: March 13, 2017Date of Patent: August 9, 2022Assignees: Baxter International Inc., Baxter Healthcare SAInventor: Yves A. Delmotte
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Patent number: 11396148Abstract: A method for making an improved contact lens with the steps of providing a mold with a space between the top surface and a bottom surface, and positioning a mat in the space of the mold, providing a bead of liquid polymer of predetermined size at a predetermined location on the surface of the mat, pressing the bead of liquid polymer into the mat between the top surface and the bottom surface of the mold to form an optical zone framed by a mat peripheral zone, exposing the optical zone and the peripheral zone with U-V radiation to harden the optical zone into a composite improved contact lens, removing the cross-linked improved contact lens from the mold, processing the peripheral zone surrounding the optical zone to have a fenestration surface having holes, the holes being through holes with predetermined diameters selected to pass larger proteins, lipids, metabolites.Type: GrantFiled: March 9, 2020Date of Patent: July 26, 2022Inventor: Randall F. Fuerst
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Patent number: 11389409Abstract: The present invention relates to transdermal devices comprising prodrugs of anti-pyretic, analgesic, or anti-inflammatory molecules, methods of making such devices, and methods of use thereof for treating, preventing, minimizing, and/or diminishing fever or pain.Type: GrantFiled: August 28, 2020Date of Patent: July 19, 2022Assignee: REMEDY DIAGNOSTICS LLCInventors: Lori Ramirez, Reza Amirzadeh, Opinya Ekabo
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Patent number: 11389410Abstract: The present invention relates to a transdermal therapeutic system, comprising (a) a backing layer, (b) a solvent-based self-adhesive matrix layer containing rotigotine as active ingredient, and (c) a release liner, wherein the self-adhesive matrix layer has a coating weight of about 75-400 g/m2 and comprises a reservoir layer containing about 9-25 wt.-% rotigotine based on the weight of the reservoir layer, a kit comprising two transdermal therapeutic systems of the present invention as well as a method for the preparation of the transdermal therapeutic system of the present invention.Type: GrantFiled: November 21, 2013Date of Patent: July 19, 2022Assignee: LTS Lohmann Therapie-Systeme AGInventors: Willi Cawello, Aurelia Lappert, Kristina Kassner, Hans-Michael Wolff, Walter Müller, Johannes Josef Leonhard, Marco Emgenbroich
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Patent number: 11389319Abstract: An ostomy barrier includes an inlet opening for receiving a stoma and a barrier adhesive including a plurality of thicker portions and a plurality of thinner portions. The plurality of thinner portions are configured and arranged to improve the flexibility of the ostomy barrier.Type: GrantFiled: November 15, 2017Date of Patent: July 19, 2022Assignee: Hollister IncorporatedInventors: Ronald S. Botten, Christina Augustyn, Russell J. Todd, Peter L. Visconti, Heather M. Budorick, Lynn Sacramento
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Patent number: 11369615Abstract: A means for substantially improving mitochondrial dysfunction is provided. An aspect of the present invention relates to an agent for improving mitochondrial dysfunction, having a compound represented by the following formula, a stereoisomer or a salt thereof, or a solvate thereof, as an active ingredient. Another aspect of the present invention relates to a medicament or a pharmaceutical composition having the aforementioned compound, a stereoisomer or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, as an active ingredient, for use in preventing or treating a disease or symptom caused by mitochondrial dysfunction.Type: GrantFiled: November 7, 2018Date of Patent: June 28, 2022Assignees: JICHI MEDICAL UNIVERSITY, TOHOKU UNIVERSITYInventors: Hitoshi Osaka, Takanori Yamagata, Eriko Jimbo, Akihiko Miyauchi, Takaaki Abe
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Patent number: 11371014Abstract: The present disclosure provides compositions and methods for producing hydrogel matrix constructs. Methods of using hydrogel matrix constructs for tissue repair and regeneration and for the oxygenation of red blood cells are also disclosed.Type: GrantFiled: October 15, 2020Date of Patent: June 28, 2022Assignee: William Marsh Rice UniversityInventors: Jordan Miller, Anderson Ta, Bagrat Grigoryan
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Patent number: 11364656Abstract: A method of forming particles for controlled guest agent release includes coextruding first and second polymer materials to form a multilayer polymer composite sheet comprising alternating first and second polymer layers, dividing the multilayer sheet into particles, immersing the particles in a solvent containing the guest agent such that the first layers swell and the guest agent is loaded into the swollen first layers.Type: GrantFiled: July 5, 2019Date of Patent: June 21, 2022Assignee: CASE WESTERN RESERVE UNIVERSITYInventors: Rigoberto Advincula, Pengfei Chao, Eric Baer
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Patent number: 11338057Abstract: Implantable scaffolds made from biopolymer fibers. Biopolymer is dissolved in acid in a closed container made of materials inert to the acid and to the collagen to form a biopolymer solution. The solution is stirred, then centrifuged to degas it. The degassed solution is put into syringes on a holder. The number of syringes equals the number of fibers in the bundle. The syringes are mounted in a rotatable holder. Essentially equal quantities of degassed solution are extruded from the syringes to produce fibers, which are gathered and fed into a formation buffer bath. The fibers are kept taught after extrusion and dehydrated in a dehydrating solution in a dehydrating bath. The fibers are wound a collector to collect the bundle. Scaffolds then are made.Type: GrantFiled: May 24, 2021Date of Patent: May 24, 2022Assignee: Embody, LLCInventors: Michael P. Francis, Stella Petrova, Nicholas Thayer
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Patent number: 11338056Abstract: A method for supporting repair of soft tissue with biopolymer fibers. Biopolymer is dissolved in acid in a closed container made of materials inert to the acid and to the collagen to form a biopolymer solution. The solution is stirred, then centrifuged to degas it. The degassed solution is put into syringes on a holder. The number of syringes equals the number of fibers in the bundle. The syringes are mounted in a rotatable holder. Essentially equal quantities of degassed solution are extruded from the syringes to produce fibers, which are gathered and fed into a formation buffer bath. The fibers are kept taught after extrusion and dehydrated in a dehydrating solution in a dehydrating bath. The fibers are wound a collector to collect the bundle. The fibers are used to support repair of soft tissue.Type: GrantFiled: May 24, 2021Date of Patent: May 24, 2022Assignee: EMBODY, INC.Inventors: Michael P. Francis, Stella Petrova, Nicholas Thayer
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Patent number: 11324851Abstract: Absorbent materials configured to sequester trimethylamine (TMA), absorbent articles made therefrom, related methods of use, methods of measuring a reduction of free TMA, and related methods of making absorbent articles are described.Type: GrantFiled: May 25, 2018Date of Patent: May 10, 2022Assignee: INTERNATIONAL PAPER COMPANYInventors: Mary Virginia Schoolfield, Hugh West
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Patent number: 11318095Abstract: The present invention provides a micelle comprising an anionic micelle and a protecting agent surrounding the anionic micelle, the anionic micelle being formed from, as a structural unit, an ingredient that has a functional group capable of being anionized under basic conditions and has anionic micelle-forming ability, the protecting agent protecting the anionic micelle. The present invention also provides a micelle comprising a cationic micelle and a protecting agent surrounding the cationic micelle, the cationic micelle being formed from, as a structural unit, an ingredient that has a functional group capable of being cationized under acidic conditions and has cationic micelle-forming ability, the protecting agent protecting the cationic micelle.Type: GrantFiled: June 1, 2018Date of Patent: May 3, 2022Assignee: TEIKA PHARMACEUTICAL CO., LTD.Inventor: Toru Okaki
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Patent number: 11311494Abstract: A formulation of a discrete liquid patch for the treatment of cold sores or viral lesions, including a combination of the adhesive layer and an active compound/ingredient such as antiviral agents, and/or amino acids, and/or minerals/vitamins. The adhesive layer of the discrete patch is substantially free of hydrocolloid particles. The adhesive layer does not include any backing layer to maintain the compliance of the patch with a thickness ranging from 5 microns to 1,300 microns. Wherein, the discrete patch of the invention is configured to apply to a viral lesion to maintain in contact therewith for a time effective to substantially complete re-epithelialization of the lesion.Type: GrantFiled: May 11, 2020Date of Patent: April 26, 2022Inventor: Adam Mark Murday
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Patent number: 11311495Abstract: A transdermal therapeutic system which is free of fibrous constituents, and a method for the production of such a transdermal therapeutic system A preparation containing active substance is applied by a printing method onto the pressure-sensitive adhesive layer of the transdermal therapeutic system.Type: GrantFiled: February 28, 2006Date of Patent: April 26, 2022Assignee: LTS Lohmann Therapie-Systeme AGInventors: Reinhold Meconi, Klaus Schumann
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Patent number: 11286372Abstract: The disclosed concept relates to compositions and methods for the manufacture of electrically resistive, thermally conductive electrical switching apparatus. The composition includes a polymer component and a nanofiber component. The thermal conductivity of the nanofiber component is higher than the thermal conductivity of the polymer component such that the electrical switching apparatus which includes the composition of the disclosed concept has improved heat dissipation as compared to an electrical switching apparatus constructed of the polymer component in the absence of the nanofiber component. Further, the disclosed concept relates to methods of towering the internal temperature of an electrically resistive, thermally conductive electrical switching apparatus by forming the internals of the apparatus, e.g., circuit breakers, and/or the enclosure from the composition of the disclosed concept.Type: GrantFiled: August 28, 2013Date of Patent: March 29, 2022Assignee: EATON INTELLIGENT POWER LIMITEDInventors: James Gerard Maloney, Edward Ethber Lias, Jeffrey Scott Gibson
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Patent number: 11278098Abstract: Encapsulated hair bands and methods for use are disclosed. An encapsulated hair band includes an encapsulated hair band, including: a horseshoe shaped hair band, having a proximal and distal end, the hair band including, flexible material capable of flexing outwardly whereby the proximal and distal ends may be displaced from an unbiased position to a biased position to fit about the wearer's head; a soft gel; and a cover, including two or more pieces, cooperating to form a cover, the two or more pieces fastened together so as to encapsulate said horseshoe shaped hair band and said soft gel, said soft gel encapsulated so that when the encapsulated hair band is placed upon the wearer's head, the soft gel is between the horseshoe shaped hair band and the cover.Type: GrantFiled: April 25, 2019Date of Patent: March 22, 2022Inventor: Virginia Claire Malkin
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Patent number: 11266535Abstract: The present invention generally relates to dressings such as bandages or tapes having improved extensibility and conformability to human skin and joints.Type: GrantFiled: April 11, 2018Date of Patent: March 8, 2022Assignee: Johnson & Johnson Consumer Inc.Inventors: Marisha Gogolowski, Carmine Rizzo
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Patent number: 11266534Abstract: The present invention generally relates to dressings such as bandages or tapes having improved extensibility and conformability to human skin and joints.Type: GrantFiled: April 11, 2018Date of Patent: March 8, 2022Assignee: Johnson & Johnson Consumer Inc.Inventors: Marisha Gogolowski, Carmine Rizzo
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Patent number: 11266361Abstract: A method of in vivo monitoring the condition of an internal body repair in which an imageable, non-absorbable repair device having non-absorbable, particulate imaging material substantially uniformly dispersed therein has been surgically inserted, including: in vivo sensing of dimensional deformation of said repair device during the post-surgical healing process; comparing the sensed values with a previously developed correlation between said sensed values and the values at which failure occurs of comparable repair devices; wherein said sensed values relative to the repair device's failure values, considered in conjunction with the anticipated time for complete healing of said repair, provides information as to the condition of the repair.Type: GrantFiled: May 9, 2019Date of Patent: March 8, 2022Assignee: S. JACKSON, INC.Inventors: Janko Jackson, Stephen L. Jackson, Crayton G. Toney
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Patent number: 11246756Abstract: Single layered nonwoven wound dressings containing (1) about 5% by weight to about 95% by weight (e.g., 5% to 95%) non-scoured, non-bleached greige cotton fibers, (2) about 5% by weight to about 95% by weight (e.g., 5% to 95%) bleached cotton fibers, and (3) about 5% by weight to about 60% by weight (e.g., 5% to 60%) hydrophobic fibers (e.g., polypropylene, nylon); all percentages adding up to 100 wt %. Also, multi-layered nonwoven wound dressings, containing (1) at least one inner layer containing (a) about 50% by weight to about 95% by weight (e.g., 50% to 95) non-scoured, non-bleached greige cotton fibers and (b) about 5% by weight to about 50% by weight (e.g., 5% to 50%) hydrophobic fibers, all percentages adding up to 100 wt %, and (2) at least one outer layer containing (a) about 5% by weight to about 95% by weight (e.g., 5% to 95%) non-scoured, non-bleached greige cotton fibers, (b) about 5% by weight to about 95% by weight (e.g.Type: GrantFiled: August 23, 2018Date of Patent: February 15, 2022Assignees: The United States of America, as represented by the Secretary of Agriculture, H & H Medical Corporation, T.J. Beall CompanyInventors: Judson V. Edwards, Joseph Dacorta, Gary Lawson
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Patent number: 11229726Abstract: In some embodiments, the present invention provides methods for making resorbable ear tubes including the steps of providing a silk fibroin solution, and forming a silk ear tube from the silk fibroin solution, wherein the silk ear tube is less than 2 mm in length and has an outer diameter of less than 1.5 mm, and wherein the silk ear tube is resorbable. In some embodiments, the present invention also provides methods for treating otitis media including the step of introducing a silk ear tube into the ear canal of a subject, wherein the silk ear tube is less than 2 mm in length and has an outer diameter of less than 1.5 mm, and wherein the silk ear tube is resorbed by the subject.Type: GrantFiled: April 1, 2021Date of Patent: January 25, 2022Assignees: Tufts University, Massachusetts Eye and Ear Infirmary, The General Hospital CorporationInventors: David Kaplan, Michael Whalen, Christopher Hartnick
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Patent number: 11225582Abstract: A water soluble polymer composition includes a water soluble polymer and a sugar and may be used as a support in additive manufacturing processes.Type: GrantFiled: July 30, 2019Date of Patent: January 18, 2022Assignee: Infinite Material Solutions, LLCInventors: Philip Brunner, Gavriel DePrenger-Gottfried, Nathan Ockwig