Web, Sheet Or Filament Bases; Compositions Of Bandages; Or Dressings With Incorporated Medicaments Patents (Class 424/443)
  • Patent number: 11116443
    Abstract: Systems and methods for accurately and efficiently diagnosing, assessing, staging/grading/categorizing, and treating pressure ulcers, as well as preventing reverse staging of pressure ulcers, are disclosed. The system, in one embodiment, ensures that the rationale for the stage assigned to the patient will be in the patients' medical record. The system, in various embodiments, further suggests the pressure ulcer classification and allows the user to choose which classification terms should be used. In various embodiments, the system also allows for the different classification/staging system guidelines to be used, including the National Pressure Ulcer Advisory Panel (NPUAP) guidelines, the European Pressure Ulcer Advisory Panel Guidelines (EPUAP), the Pan Pacific Pressure Injury Alliance, CMS, WHO, and the MDS Guidelines.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: September 14, 2021
    Assignee: Universal Care Solutions, LLC
    Inventor: Candice Ganey Curtin
  • Patent number: 11116769
    Abstract: The present disclosure relates to a film formulation for oral administration, containing tadalafil free base and a method of preparing the same, and a film may be provided with maximized dispersion stability of tadalafil free base in the film by the addition of a dispersion stabilizing agent in small amounts without unique fragrance or favor that may appear when other dispersion stabilizing agents known in the art are used, and an extremely low likelihood that a reagglomeration phenomenon of tadalafil free base particles will occur, and an amount of bubbles generated may be significantly reduced during a production process.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: September 14, 2021
    Assignee: CTC BIO, INC.
    Inventors: Hong Ryeol Jeon, Do-Woo Kwon, Bong-Sang Lee, Su-Jun Park, Bong-Geun Cha, Jun-Ki Kim, Jiyeong Han, Myeongcheol Kil
  • Patent number: 11109975
    Abstract: A scaffold is provided which facilitates integration of both bone and cartilage at an osteochondral lesion, thereby acting as a tissue engineered interface or tissue engineered junction between the two different tissues. The method and systems for engineering this interface may be acellular or may be loaded with cells prior to use.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: September 7, 2021
    Assignee: Cytex Therapeutics, Inc.
    Inventors: Bradley T. Estes, Franklin Thomas Moutos, Farshid Guilak
  • Patent number: 11102979
    Abstract: An antimicrobial article that includes: an antimicrobial composite region that includes a matrix comprising a polymeric material, and a first plurality of particles within the matrix. The particles include a phase-separable glass with a copper-containing antimicrobial agent. The antimicrobial composite region can be a film containing the first plurality of particles that is subsequently laminated to a bulk element. The first plurality of particles can also be pressed into the film or a bulk element to define an antimicrobial composite region. An exposed surface portion of the antimicrobial composite region can exhibit at least a log 2 reduction in a concentration of at least one of Staphylococcus aureus, Enterobacter aerogenes, and Pseudomonas aeruginosa bacteria under a Modified EPA Copper Test Protocol.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: August 31, 2021
    Assignee: Corning Incorporated
    Inventors: Dayue Jiang, Kevin Andrew Vasilakos, Frederic Christian Wagner, Carlo Anthony Kosik Williams
  • Patent number: 11101463
    Abstract: A copolymer for binders, which is capable of reducing the internal resistance of a battery, while ensuring sufficient binding properties between active materials and between an active material and a collector in a nonaqueous battery electrode; a composition for binders; a slurry for nonaqueous battery electrodes; a nonaqueous battery electrode; and a nonaqueous battery. This copolymer for binders is a copolymer for binders (P) of a monomer mixture (M) that contains at least a monomer (A) represented by general formula (1) and a (meth)acrylate salt monomer (B); and an amount of structure derived from the monomer (A) based on the copolymer for binders (P) is set to 0.5 to 20.0% by mass. (In the formula, each of R1 and R2 independently represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: August 24, 2021
    Assignee: SHOWA DENKO K.K.
    Inventors: Mitsuru Hanasaki, Yasuhiro Nakagawa
  • Patent number: 11098441
    Abstract: A method is provided for producing a fiber fabric by preparing a finishing agent treatment liquid having a mixture of first and second particles of titanium oxide having a particle diameter of 150 to 200 nm and 1 to 5 ?m respectively, a silver zeolite and a binder resin, immersing a fiber fabric in the finishing agent, thermal drying the fiber fabric and subjecting the fiber fabric to heat treatment to allow the finishing agent to adhere to the fiber fabric.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: August 24, 2021
    Assignee: AS CORPORATION
    Inventor: Shigeru Nohara
  • Patent number: 11078521
    Abstract: The present invention and embodiments thereof relates to compositions and methods for storage, stabilization and preservation of biological samples and/or nucleic acids on a solid matrix. Methods for extracting, collecting, and recovering the biological samples and/or nucleic acids from the solid matrix are also described.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: August 3, 2021
    Assignee: BIOMATRICA, INC.
    Inventors: Joel Desharnais, Daniela Roth, Vasco Liberal
  • Patent number: 11071745
    Abstract: The present disclosure provides compositions and methods for the prevention of HSV infection in an HSV seronegative individual.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: July 27, 2021
    Assignee: ELIAN LLC
    Inventors: Emidio A. Checcone, Christina Ramirez
  • Patent number: 11065295
    Abstract: Compositions and methods are presented in which a plurality of chemically distinct polyphenols inhibit multiple enzymes in pathways associated with health and healthy ageing. Preferred compositions are derived from colored plant materials that are commonly found in the Mediterranean diet and provide the biochemical basis for the health benefits of the Mediterranean diet. Notably, the enzyme inhibition observed with the combined polyphenols was synergistic with respect to not one but a significant number of enzymes in the pathways associated with health and healthy ageing, thus providing an amplified desirable effect.
    Type: Grant
    Filed: February 4, 2021
    Date of Patent: July 20, 2021
    Assignee: DAILYCOLORS HEALTH INC.
    Inventor: Hartley Pond
  • Patent number: 11045518
    Abstract: Compositions and methods are presented in which a plurality of chemically distinct polyphenols inhibit multiple enzymes in pathways associated with health and healthy ageing. Preferred compositions are derived from colored plant materials that are commonly found in the Mediterranean diet and provide the biochemical basis for the health benefits of the Mediterranean diet. Notably, the enzyme inhibition observed with the combined polyphenols was synergistic with respect to not one but a significant number of enzymes in the pathways associated with health and healthy ageing, thus providing an amplified desirable effect.
    Type: Grant
    Filed: February 4, 2021
    Date of Patent: June 29, 2021
    Assignee: DAILYCOLORS HEALTH INC.
    Inventor: Hartley Pond
  • Patent number: 11040043
    Abstract: The present invention provides compositions and methods for providing sustained release of an active agent through the skin of a subject, wherein a pharmaceutical percutaneous composition comprises at least one fatty acid ester and a therapeutically effective amount of active agent.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: June 22, 2021
    Assignee: BESINS HEALTHCARE LUXEMBOURG SARL
    Inventors: Valerie Masini-Eteve, Denis Canet
  • Patent number: 11033512
    Abstract: The present invention relates to transdermal therapeutic systems (TTS) for the transdermal administration of asenapine comprising an asenapine-containing layer structure, said asenapine-containing layer structure comprising A) a backing layer and B) an asenapine-containing layer, wherein the transdermal therapeutic system comprises a silicone acrylic hybrid polymer.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: June 15, 2021
    Assignee: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventors: Patrick Mohr, René Rietscher, René Eifler, Olga Bourquain
  • Patent number: 11020509
    Abstract: A biopolymer fiber containing collagen. The biopolymer fiber has excellent ultimate tensile strength, modulus of elasticity, and strain at break comparable to native human tendons and ligaments. The fiber may substantially circular, ovoid, square, rectangular, ribbon-like, triangular, or irregularly shaped. The fiber exhibits an ordered, longitudinally-oriented structure, and the fiber allows infiltration of cellular growth. Implantable biopolymer scaffolds and sutures containing the fibers are provided as well as microfluidic and extrusion methods for producing the biopolymer fibers.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: June 1, 2021
    Assignee: Embody, Inc.
    Inventors: Michael P. Francis, Stella Petrova, Nicholas Thayer
  • Patent number: 11013827
    Abstract: The invention relates to the field of tissue engineering and regenerative medicine, and particularly to a three-dimensional biomimetic tissue scaffold that exploits the use of three-dimensional print technology. Surface energy is controlled by precisely placing polymers with differing surface chemistry, and using surface texture and bulk composition to pattern absorbable and non-absorbable polymers for the purpose of promoting functional healing in a mammalian body.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: May 25, 2021
    Assignee: BVW Holding AG
    Inventors: Lukas Bluecher, Michael Milbocker
  • Patent number: 11013602
    Abstract: An alloprosthetic composite implant comprising includes a structural porous scaffold having a pore density profile corresponding to a density profile of bone to be replaced. A plurality of cells are seeded within pores of the porous scaffold and grown by incubation. The cells may include osteoblasts and/or stem cells to form the structure of the implant, and one or more cartilage layers may be grown on top of the scaffold. The pore density profile of the scaffold may be formed based on one or both of the bone density profile of the bone to be removed, and the bone density profile of the native bone that will be in contact with the alloprosthetic implant. A robot may be employed reo resect the native bone and also to shape the alloprosthetic implant to fit into place in the native bone.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: May 25, 2021
    Assignee: Mako Surgical Corp.
    Inventor: Peter M. Bonutti
  • Patent number: 11007482
    Abstract: A draw solute for forward osmosis comprising a semi-interpenetrating (semi-IPN) hydrogel which comprises a thermally responsive polymer and a hydrophilic polymer, such that the semi-IPN hydrogel is capable of switching between a hydrophilic and hydrophobic state in response to changes in temperature is provided. Also provided is a draw solute comprising a hydrogel of a polyionic thermally responsive polymer, wherein the hydrogel switches between a hydrophilic state to allow absorption of water osmosed from a feed solution and a hydrophobic state to allow release of the absorbed water in response to changes in temperature. There is also provided a forward osmosis method comprising: contacting a feed solution and the draw solute via a semi-permeable membrane, such that feed water in the feed solution passes through the membrane by osmotic pressure and moves into the draw solute; and separating the water from the draw solute to form a purified water product.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: May 18, 2021
    Assignee: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Xiao Hu, Yufeng Cai, Rong Wang
  • Patent number: 11001751
    Abstract: The invention provides polymers comprising repeating units derived from at least one monomer comprising at least one functionalized or unfunctionalized acryloyl moiety and at least one lactam moiety; at least one monomer comprising at least one sulfonic acid moiety or a salt thereof; and at least one crosslinker. The invention further provides various compositions comprising the polymers. The invention furthermore provides applications of these compositions in various industrial arts, particularly in oilfield operations such as drilling and cementing.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: May 11, 2021
    Assignee: HERCULES LLC
    Inventors: Ryan Vincent Blazewicz, Janice Jianzhao Wang, Brent R. Gonska
  • Patent number: 11000473
    Abstract: Disclosed is a dissolvable film adapted to adhere to an oral mucosal tissue of a subject, wherein the film comprises at least three indigestible hydrophilic polymers constituting from 35% to 55% of the film dry weight and wherein the at least three polymers comprise xanthan gum and carboxymethyl cellulose (CMC) in a weight ratio of between 1:0.8-1.6, and at least one other cellulose based polymer. Optionally, the film may further include an active agent in an amount of 0.01% to 35% of the film dry weight. Disclosed also is a method for preparing the film and a method for treating or preventing oral conditions comprising implementing the film. Particularly, the film may be applied between dentures and the gums of the user.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: May 11, 2021
    Assignee: PHARMEDICA LTD.
    Inventors: Yoram Rubin, David Tavor, Hock Tan, Odeya Tairy
  • Patent number: 11000554
    Abstract: Cells derived from postpartum placenta and methods for their isolation are provided by the invention. The invention further provides cultures and compositions of the placenta-derived cells. The placenta-derived cells of the invention have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: May 11, 2021
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Anthony J. Kihm, Ian R. Harris, Sanjay Mistry, Alexander M. Harmon, Darin J. Messina, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
  • Patent number: 11001969
    Abstract: The present invention relates to a new process for creating foam in a process for manufacturing a paper or board product. According to the present invention, certain types of antimicrobial starch is used in the creation of the foam.
    Type: Grant
    Filed: July 3, 2017
    Date of Patent: May 11, 2021
    Assignee: Stora Enso OYJ
    Inventors: Kaj Backfolk, Isto Heiskanen, Esa Saukkonen, Kirsi Partti-Pellinen, Simo Siitonen
  • Patent number: 10994303
    Abstract: Methods for producing a transparent conductive film and transparent conductive pattern having superior in-plane uniformity of resistance, by a printing method of slit coating or roll coating of metal nanowire ink. The methods include applying a metal nanowire ink containing metal nanowires, a binder resin containing more than 50 mol % monomer units derived from N-vinylacetamide, and a solvent, to at least one surface of a transparent resin film and drying to form a transparent conductive layer, the application of the metal nanowire ink to the transparent resin film being application by slit coating or roll coating performed using a transparent resin film and metal nanowire ink with which the advancing angle (?a) of the dynamic contact angle of the metal nanowire ink relative to the transparent resin film satisfies 10.0°<?a?25.0°, and the difference (?a??r) between the advancing angle (?a) and the receding angle (?r) is 10.0° or higher.
    Type: Grant
    Filed: January 15, 2018
    Date of Patent: May 4, 2021
    Assignee: SHOWA DENKO K.K.
    Inventor: Shigeru Yamaki
  • Patent number: 10988600
    Abstract: A hyaluronic acid product is comprising a cross-linked hyaluronic acid and one or more cyclodextrin molecules, and further comprising a guest molecule capable of forming a guest-host complex with the aminocyclodextrin molecule acting as a host, wherein the guest molecule is a retinoid, preferably adapalene, or a RAM BA. The hyaluronic acid is cross-linked by ether bonds, and the one or more cyclodextrin molecules are grafted onto the cross-linked hyaluronic acid by amide bonds, preferably using a triazine-based coupling reagent.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: April 27, 2021
    Assignee: GALDERMA HOLDING SA
    Inventors: Katarina Edsman, Jean-Guy Boiteau
  • Patent number: 10986857
    Abstract: The present invention provides compositions and methods for the dietary management of nephrolithiasis and hypocitraturia through the oral administration of multiple alkali salts including sodium bicarbonate, potassium citrate and/or magnesium citrate. Also provided are kits including compositions for the dietary management of nephrolithiasis and hypocitraturia.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: April 27, 2021
    Assignee: LithoLyte Corporation
    Inventor: Ryan Holland
  • Patent number: 10988900
    Abstract: A soft tissue having a soothing feel and method of making the same is disclosed which contains an aqueous softening composition comprising from about 10 to about 20 weight percent of a cationic softening compound, such as quaternary ammonium compounds and imidazolinium compounds; from about 10 to about 20 weight percent of a polyhydroxy compound having a molecular weight of at least about 1,000 g/mol, and optionally a silicone or glycerin. Examples of the cationic softening compound include tallow- and ester-substituted quaternary ammonium compounds having chloride or methyl sulfate as the anion, and examples of the polyhydroxy compound include polyethylene glycols (PEG) or polypropylene glycols (PPG) having a molecular weight of at least about 1,000 g/mol, such as PEG-1000 and PEG-8000.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: April 27, 2021
    Assignee: KIMBERLY-CLARK WORLDWIDE, INC.
    Inventors: SangGil Lee, EunSeok Yeom
  • Patent number: 10989867
    Abstract: A fiber-based sensor and a method of forming a fiber-based sensor using microsphere lithography techniques in which a microsphere array is applied to a surface of a tip of an optical fiber to provide for microsphere lithography fabrication of a desired pattern on the tip of the optical fiber. The characteristics of the pattern define sensing capabilities of the sensor to provide for chemical and/or biological sensing.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: April 27, 2021
    Assignee: The Curators of the University of Missouri
    Inventors: Edward C. Kinzel, Mahmoud Almasri, Chuang Qu, Ibrahem Jasim, Jiayu Liu
  • Patent number: 10973794
    Abstract: Use of a composition for the prevention, amelioration and/or treatment of conditions, disorders and/or diseases associated with senescence and/or inflammation of the teeth and/or associated structures and tissues in the mouth, the composition comprising a conjugate of quinic acid with at least one molecule of caffeic acid, or a derivative, isomer or salt thereof.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: April 13, 2021
    Assignee: CALSCIENCE INTERNATIONAL LTD.
    Inventors: Iain William George Forbes, William Forbes
  • Patent number: 10959454
    Abstract: An oral product includes a body that is wholly receivable in an oral cavity. The body includes a mouth-soluble polymer matrix, cellulosic fibers embedded in the mouth-soluble polymer matrix, and nicotine or a derivative thereof dispersed in the mouth-soluble polymer matrix. The oral product is adapted to release the nicotine or a derivative thereof from the body when the body is received within the oral cavity and exposed to saliva.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: March 30, 2021
    Assignee: Altria Client Services LLC
    Inventors: Feng Gao, Frank Scott Atchley, Gregory Griscik, Christopher Joseph DiNovi, Phillip M. Hulan
  • Patent number: 10954415
    Abstract: An aqueous noctilucent and allochroic glue that includes deionized water; a noctilucent material that includes long-afterglow phosphor powder and a transparent medium, wherein the noctilucent material includes particles formed by creating, curing, and then crushing a suspension, mixture, or sheet of the long-afterglow phosphor powder and transparent medium, and wherein the particles have been coated with allochroic material; adhesive; and suspension concentrate.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: March 23, 2021
    Inventor: Li Yeping
  • Patent number: 10945932
    Abstract: The present invention provides an oral care composition comprising a carboxylic acid of the formula (I) wherein: R1 is H, or is a substituted or unsubstituted alkyl group; and R2 is H, OH, or NH2; for use in: (a) selectively promoting, in an oral cavity: growth, metabolic activity or colonization of bacteria that have beneficial effects on oral health, relative to growth, metabolic activity or colonization of pathogenic oral bacteria; (b) selectively promoting, in an oral cavity, biofilm formation by bacteria that have beneficial effects on oral health, relative to biofilm formation by pathogenic oral bacteria; or (c) maintaining and/or re-establishing a healthy oral microflora.
    Type: Grant
    Filed: December 27, 2013
    Date of Patent: March 16, 2021
    Assignees: Colgate-Palmolive Company, Katholieke Universiteit Leuven
    Inventors: Hans Stettler, Wim Teughels, Marc Quirynen, Nico Boon
  • Patent number: 10941268
    Abstract: The present invention relates to a cosmetic-supporting structure, including a reticulated porous foam and a silicone coating layer, serving as an outer frame, on an outer surface of the foam, serving as an inner frame, a method of manufacturing the same, and a cosmetic product containing the same.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: March 9, 2021
    Assignee: Kolon Industries, Inc.
    Inventors: Tae-Hwan Ahn, Min-Ho Choi
  • Patent number: 10933090
    Abstract: Pharmaceutical compositions for oral administration, in particular administration as an oral delivery system to be swallowed directly or capable of disintegration in the oral cavity, comprising iron oxy-hydroxide in high loading.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: March 2, 2021
    Assignee: Vifor Fresenius Medical Care Renal Pharma Ltd
    Inventors: Ludwig Daniel Weibel, Erik Philipp
  • Patent number: 10925897
    Abstract: Pharmaceutical compositions for oral administration, in particular administration as an oral delivery system to be swallowed directly or capable of disintegration in the oral cavity, comprising iron oxy-hydroxide in high loading.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: February 23, 2021
    Assignee: Vifor Fresenius Medical Care Renal Pharma Ltd
    Inventors: Ludwig Daniel Weibel, Erik Philipp
  • Patent number: 10925896
    Abstract: Pharmaceutical compositions for oral administration, in particular administration as an oral delivery system to be swallowed directly or capable of disintegration in the oral cavity, comprising iron oxy-hydroxide in high loading.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: February 23, 2021
    Assignee: Vifor Fresenius Medical Care Renal Pharma Ltd
    Inventors: Ludwig Daniel Weibel, Erik Philipp
  • Patent number: 10912857
    Abstract: A lotion composition is provided. The lotion composition includes a) about 1% to about 90%, by weight, of a rheology structurant; and a b) carrier.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: February 9, 2021
    Assignee: The Procter & Gamble Company
    Inventors: Robert Ya-lin Pan, Debora Christine Ebert, Peter Christopher Ellingson, Raphael Warren
  • Patent number: 10897978
    Abstract: Disclosed are composition and methods for treating skin whereby a cosmetic composition is applied to a target area of skin. The cosmetic composition comprises an effective amount of a skin active agent. A barrier patch is also provided and has a backing layer and a pressure sensitive adhesive. The barrier patch has an adhesive release force of about 50 gms to about 400 gms; a WVTR from about 1 g/m2/24 h to about 500 g/m2/24 h; and a flexibility from about 8 grams to about 40 grams.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: January 26, 2021
    Assignee: The Procter & Gamble Company
    Inventors: Elizabeth Anne Wilder, Paul Jonathan Matts, Nicole Annette Mosby, Colin John Clarke
  • Patent number: 10897895
    Abstract: Methods of providing sustained sterilization of thermoplastics; providing thermoplastics that have the capacity to dispense sodium fluoride, and, a method of providing sustained sterilization of thermoplastics and providing thermoplastics that have the capacity to dispense sodium fluoride, both from the same thermoplastic article.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: January 26, 2021
    Assignee: QuadSil, Inc.
    Inventors: John D. Blizzard, Joan McMahon, Michael Silver
  • Patent number: 10898617
    Abstract: The disclosure concerns various medical devices implemented to provide a nitric oxide rich environment for anti-microbial or anti-thrombogenic benefits. The medical device generally includes a nitric oxide donor material that is contained within a sealed cavity, and a transport medium that defines and captivates the entirety of the cavity, wherein the transport medium is permeable to both water and nitric oxide. As the nitric oxide donor material becomes saturated with water from the surrounding tissue or fluids, nitric oxide is chemically released, and the resulting nitric oxide is communicated through the transport medium to a treatment site for anti-microbial and anti-thrombogenic benefits.
    Type: Grant
    Filed: January 21, 2018
    Date of Patent: January 26, 2021
    Assignee: BIOCREDE INC.
    Inventors: Hao Chen, Kevin Renehan, Kwun Yin Ho, Alexander Wolf
  • Patent number: 10888580
    Abstract: The present invention provides methods for alleviating pain and discomfort associated with a dry eye condition; methods for alleviating pain and discomfort while minimizing at least one skin imperfection; and methods for alleviating pain and discomfort while facilitating wound healing. The methods involve administering to a subject in need thereof a composition comprising hyaluronan with high elasticity.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: January 12, 2021
    Assignee: Matrix Biology Institute
    Inventors: Carlos Belmonte, Janet L. Denlinger
  • Patent number: 10881637
    Abstract: Methods of treating neuropsychiatric disorders including affective disorders and addiction involve intranasal or transdermal administration of a substantially selective kappa-opioid-receptor agonist that is also a partial D2 agonist, such as the compound salvinorin A. Also disclosed are intranasal, transdermal and/or inhalation systems for delivering the kappa-opioid-receptor agonist.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: January 5, 2021
    Inventor: Atlee Solomon
  • Patent number: 10874384
    Abstract: A sealant is provided for sealing a puncture through tissue that includes an elongate first section including a proximal end, a distal end, and a cross-section sized for delivery into a puncture through tissue, and a second section fused to and extending from the distal end of the first section. The first section may be formed from a freeze-dried hydrogel that expands when exposed to physiological fluid within a puncture. The second section may be formed from a solid mass of non-freeze-dried, non-crosslinked hydrogel precursors, the precursors remaining in an unreactive state until exposed to an aqueous physiological, whereupon the precursors undergo in-situ crosslinking with one another to provide an adhesive layer bonded to the first section. Apparatus and methods for delivering the sealant into a puncture through tissue are also provided.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: December 29, 2020
    Assignee: AccessClosure, Inc.
    Inventors: Andy H. Uchida, Anthony P. Spizuoco, Kevin To, Florencia Lim, Scott R. Sershen
  • Patent number: 10869949
    Abstract: A method, material, and kit for promoting neutrophils and monocytes to localize at a chronic ulcer site, promoting formation of a multi-layered cell structure in the ulcer site, promoting conversion of monocytes to macrophages, promoting secretion of the patient's own growth factors, promoting tissue proliferation and cell migration, promoting production and cross-linking of collagen at the chronic ulcer site, promoting growth of endothelial cells, promoting angiogenesis that was stalled at the chronic ulcer site, promoting formation of a vascular network and granulation, promoting oxygenation of the chronic ulcer site, and reducing one or more of purulent drainage, erythema, pain, warming, tenderness, induration, and bleeding at the chronic ulcer site.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: December 22, 2020
    Assignees: Geistlich Pharma AG, University of Southern California
    Inventors: Charles Zelen, David Armstrong, Paul Glat, Jarrod Kaufman, Marco Mehr, Lothar Schloesser, Mark Spilker
  • Patent number: 10849733
    Abstract: The present invention relates to a glucose-reactive artificial muscle, and more particularly, to a carbon nanotube, a hydrogel-based glucose-reactive artificial muscle which has a reversible volume change due to variations in glucose concentration, a method of forming the same, a rotary artificial muscle using the same, and a method of detecting glucose. The glucose-reactive artificial muscle according to the present invention may sense variations in glucose concentration with high sensitivity within a short time by providing reversible twisting using the swelling and shrinkage of hydrogels, which occur due to a change in internal anionic charges, caused by the bonding between a boronic acid introduced to the hydrogels and glucose.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: December 1, 2020
    Assignee: Industry-University Cooperation Foundation Hanyang University
    Inventors: Seon Jeong Kim, Sachan Ko
  • Patent number: 10851472
    Abstract: A method of producing an apatite crystal includes the steps of preparing an apatite single crystal expressed by the general formula M25(PO4)3X (M2 being at least atomic element selected from the group consisting of divalent alkaline-earth metals and Eu, and X is at least one atomic selected from the group consisting of halogens); placing the apatite single crystal into a space controllable to a predetermined atmosphere; supplying water vapor into the space; and heating such that the atmosphere in the space is within a 1000° C. to 1400° C. range.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: December 1, 2020
    Assignee: KOITO MANUFACTURING CO., LTD.
    Inventors: Yu Shinomiya, Kazumichi Yanagisawa, Masoud Sakaki
  • Patent number: 10842928
    Abstract: A medicine-holding body is disposed in a flow path of a nozzle portion of an adapter for blood dispensing. The medicine-holding body is formed of a plurality of fibers which is made of polyester and is bundled by aligning a longitudinal direction thereof in a flowing direction which is a direction in which blood flows. The medicine-holding body holds an anticoagulant for suppressing coagulation of blood, as a medicine to be mixed into blood. The surface area of the medicine-holding body is greater than or equal to 10 mm2 and less than 600 mm2. In a case where the surface area of the medicine-holding body is greater than or equal to 10 mm2, the concentration of the anticoagulant becomes greater than or equal to a lower limit value of 10 U/mL even under most severe conditions such as a dispensing speed of 500 ?L/second. In a case where the surface area of the medicine-holding body is less than 600 mm2, it is possible to maintain the occurrence rate of hemolysis to be less than or equal to 10%.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: November 24, 2020
    Assignee: FUJIFILM Corporation
    Inventors: Toshihito Kimura, Toshiaki Kuniyasu, Hirotaka Watano, Akira Wakabayashi, Hiroshi Makino
  • Patent number: 10835569
    Abstract: The present invention includes compositions and methods for cleaning, treating, protection and resolution of decubitus ulcers comprising: a first composition comprising a wound cleaning solution comprising aloe vera gel comprising at least 5,000 MPS, a balanced salt solution; and a second composition comprising a wound healing gel comprising aloe vera gel comprising at least 10,000 MPS, a thickening agent, and one or more preservatives and, optionally, a third composition comprising a moisture barrier cream comprising a vegetable-based emulsifier, a cosmetic ester for dry skin that has low occlusivity, an ester-based emollient that is oxidation stable and has low occlusivity; a beeswax; a hydrogenated oil, glycerin, a buffering agent, aloe vera gel comprising at least 2,000 MPS and water.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: November 17, 2020
    Assignee: Aloe Bioscience, LLC
    Inventor: Ivan E. Danhof
  • Patent number: 10828910
    Abstract: The present teachings include a process, system and article for forming a printed image on a textile. In some embodiments, the process includes coating the textile with a layer of polydiallyldimethyl ammonium chloride cationic polymer and coating the textile with the layer of polydiallyldimethyl ammonium chloride cationic polymer with a layer of poly-4-styrene sulfonate anionic polymer. The process can further include applying an ink composition to the textile having the layer of polydiallyldimethyl ammonium chloride cationic polymer layer and the layer of poly-4-styrene sulfonate anionic polymer, forming an image.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: November 10, 2020
    Assignees: Xerox Corporation, Palo Alto Research Center
    Inventors: Naveen Chopra, Paul J. McConville, Jennifer L. Belelie, Anthony S. Condello, Robert A. Street, Warren Jackson
  • Patent number: 10829621
    Abstract: Disclosed herein are water-soluble films and resulting packets including a water soluble film, wherein the water-soluble film includes a water-soluble mixture of polyvinyl alcohol, a compatibilizing agent, and a sugar alcohol plasticizer that is a solid at room temperature, wherein the water-soluble film is substantially transparent.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: November 10, 2020
    Assignee: MONOSOL, LLC
    Inventors: David M. Lee, Jennifer L. Childers
  • Patent number: 10828254
    Abstract: An oral film dosage form includes a high viscosity polymer in an amount of from 1% to 5% by dry weight to reduce, modulate and/or control Cmax of an active agent. The high viscosity polymer has a viscosity of from 100 cps to 500 cps as determined at 2% concentration in water by weight at 25° C. using a Brookfield LVF viscometer with spindle no. 2 at 60 rpm.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: November 10, 2020
    Assignee: INTELGENX CORP.
    Inventors: Nadine Paiement, Rodolphe Obeid, Justin W. Conway, Billal Tir
  • Patent number: 10821211
    Abstract: Methods are provided to produce optimal fractionations of charged keratins that have superior biomedical activity. Also provided are medical implants coated with these keratin preparations. Further provided are methods of treating blood coagulation in a patient in need thereof.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: November 3, 2020
    Assignee: Wake Forest University Health Sciences
    Inventor: Mark E. Van Dyke
  • Patent number: 10821203
    Abstract: A dressing composition for use as a skin dressing comprises an elastomeric-adhesive composition, and a zeolite comprising releasably adsorbed nitric oxide. The zeolite may comprise a transition metal cation such as Co, Fe, Mn, Ni, Cu, Zn, Ag or a mixture thereof as an extra-framework metal cation, preferably Zn. The elastomeric adhesive composition may be a hydro-colloid-adhesive composition comprising, hydrocolloid and elastomer. The dressing composition releases nitric oxide, which may have beneficial effects, when used on wounds or moist skin, with a substantially constant release rate over a long period of time. A dressing including a layer of the dressing composition has a backing layer and may have a release liner removably attached to the skin-contacting surface of the dressing layer.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: November 3, 2020
    Assignee: PQ Silicas UK Limited
    Inventors: Abraham Araya, Alan Reginald Minihan, Paul Matthew Robbins, Sonya Theresa Broderick, Michael J. Waring