Web, Sheet Or Filament Bases; Compositions Of Bandages; Or Dressings With Incorporated Medicaments Patents (Class 424/443)
  • Patent number: 10695364
    Abstract: Compositions comprising a citrate salt and a calcium carbonate-containing material, articles-of-manufacturing and kits comprising same and uses thereof for inducing blood coagulation and/or for reducing or arresting hemorrhaging, particularly internal hemorrhaging, are disclosed.
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: June 30, 2020
    Assignee: Ariel-University Research and Development Company Ltd.
    Inventors: Danny Baranes, Ayala Gancz, Yekaterina Zuev, Liat Hammer
  • Patent number: 10688125
    Abstract: The present invention provides a nanoparticle comprising a core comprising a metal; and a corona comprising a plurality of ligands covalently linked to the core, the plurality of ligands including at least a first species of ligand comprising an ethylene glycol portion and an amine group and at least a second species of ligand comprising a carbohydrate group, for use in a method of treating a cancer, particularly skin cancer, in a mammalian subject. Also disclosed are methods of treatment by administering the nanoparticles alone or in combination with radiotherapy.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: June 23, 2020
    Assignee: Midatech Ltd.
    Inventors: Jon Golding, Phillip Williams, Meike Roskamp
  • Patent number: 10682370
    Abstract: The present invention provides a novel pharmaceutical composition and method of making the same. The composition comprises an effective amount of an antiviral agent and a local anesthetic. The antiviral drug can be sorivudine. The local anesthetic can be lidocaine or its pharmaceutically acceptable salt. Herpes virus infections in humans can be caused by different human herpes viruses, the most common being herpes simplex virus types 1 and 2 (HSV1 and HSV2) and varicella-zoster virus (VZV).
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: June 16, 2020
    Assignee: NAL PHARMACEUTICAL GROUP LIMITED
    Inventors: Je Phil Ryoo, Chun Kwong Chu
  • Patent number: 10683434
    Abstract: Aqueous dispersions of copolymers of ethylenically unsaturated monomers and silicone resins bearing functional groups which are free radically polymerizable are prepared by forming an aqueous miniemulsion of the silicone resin dissolved in an ethylenically unsaturated monomer, the miniemulsion having a D50 droplet size <350 nm, and polymerizing using a free radical polymerization initiator.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: June 16, 2020
    Assignee: WACKER CHEMIE AG
    Inventors: Frank Sandmeyer, Amanda Andrews, James Greene
  • Patent number: 10681912
    Abstract: A dispersion solution containing ultrafine metal particles, comprising a low-boiling solvent and, contained therein, ultrafine metal particles of any one of Ag, Cu or Zn having a fatty acid and a glyceride coordinated on the surfaces thereof. The dispersion solution contains, dispersed therein, ultrafine metal particles that have excellent antibacterial power at a high concentration without being aggregated. The dispersion solution maintains excellent dispersion property even after the passage of long periods of time and also exhibits very high degree of transparency even when it is mixed into a resin composition.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: June 16, 2020
    Assignee: TOYO SEIKAN GROUP HOLDINGS, LTD.
    Inventors: Kazuaki Ohashi, Yasuhiro Kosaka, Akiko Ogata, Hiroshi Shimomura, Akira Ishiko
  • Patent number: 10653815
    Abstract: Methods of forming a composition for treatment, compositions for treatment, and methods of treatment with the compositions are provided. The methods can include coating a synthetic material substrate with a biologic material. A portion of the biologic material can be acid-swelled.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: May 19, 2020
    Assignee: LifeCell Corporation
    Inventors: Hui Xu, Sean Collins, Li Ting Huang, Hua Wan, Yi Chen
  • Patent number: 10646413
    Abstract: A web material containing one or more active agents and methods for making same are provided.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: May 12, 2020
    Assignee: The Procter & Gamble Company
    Inventors: Mark Robert Sivik, Gregory Charles Gordon, Frank William Denome, Alyssandrea Hope Hamad-Ebrahimpour, Stephen Joseph Hodson, Brian Patrick Croll, John Gerhard Michael, Andreas Josef Dreher, Paul Dennis Trokhan
  • Patent number: 10638749
    Abstract: A disinfestation article includes a base, external voids and internal voids formed in the base, pesticidal compound disposed in the external and internal voids. The pesticidal compound disposed in the external void being exposed to a surface of the base. The article may further comprise channels connecting one of the internal voids to one of the external voids. The pesticidal compound contains pesticidal particles selected from pyrethroid family or the like. Also claimed is a method of manufacturing which includes mixing pesticidal particles into a molten polymer material to form a mixture, injecting the mixture into a mold to form a molded part, and cooling the molded part to form said disinfestation article.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: May 5, 2020
    Inventor: Dong Lin Eugene Tan
  • Patent number: 10629648
    Abstract: A production method for a semiconductor epitaxial wafer includes: irradiating a surface of a semiconductor wafer with cluster ions to form a modified layer in a surface portion of the semiconductor wafer, in which the modified layer includes a constituent element of the cluster ions in solid solution. The production method further includes forming an epitaxial layer on the modified layer of the semiconductor wafer. The irradiating is performed such that a portion of the modified layer in a thickness direction becomes an amorphous layer and an average depth of an amorphous layer surface from a semiconductor wafer surface-side of the amorphous layer is at least 20 nm from the surface of the semiconductor wafer.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: April 21, 2020
    Assignee: SUMCO CORPORATION
    Inventor: Ryosuke Okuyama
  • Patent number: 10617120
    Abstract: A bio control surface (100) comprising a substrate (5) and a first plurality of discrete, spaced-apart particles (1) disposed on the substrate (5) and a second plurality of discrete, spaced-apart particles (6) disposed on the substrate (5), wherein the first (1) and second (6) pluralities of discrete, spaced-apart particles are formed from species having different chemical and/or electrical properties. An intermediate layer (4) may be interposed between the particles (1, 6) and the substrate (5). The bio control surface (100) can be activated by exposure to particular conditions, which cause the first (1) and second (6) pluralities of particles to adopt different potentials (+, ?), such that flow of charge, heat, ions etc. can be used to neutralise or kill bacteria or microorganisms resident on the surface (100).
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: April 14, 2020
    Assignee: Gencoa Ltd.
    Inventors: Victor Bellido-Gonzalez, Dermot Patrick Monaghan
  • Patent number: 10617894
    Abstract: The present invention relates to a composition, textile, and mask for reducing the inhalation of pollutants. The composition includes an aqueous solution of an inorganic iodide compound, a metal phthalocyanine, and a polymeric binder. The inorganic iodide can be cuprous iodide, the metal phthalocyanine can be iron phthalocyanine, and the polymeric binder can be polyvinylpyrrolidone or polyvinyl alcohol. This pollutant-inactivating composition neutralizes pollutants such as nitrogen dioxide, sulfur dioxide, ozone, volatile organic compounds and other unpleasant airborne agents, without requiring elevated temperatures or bulky canisters containing adsorbents. Optionally, a humectant can also be incorporated into the coating solution to retain moisture in the active filter matrix, which enhances the activity of the composition to inactivate oxidizing gases and other toxic constituents of air pollution.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: April 14, 2020
    Assignee: Innonix Technologies, Incorporated
    Inventors: Wylie Wing Nien O, Neal George Stewart, Reid Warren von Borstel
  • Patent number: 10603293
    Abstract: Solid-forming local anesthetic formulations for pain control can include a lidocaine base and tetracaine base, polyvinyl alcohol, water, and an emulsifier. The formulation can be prepared to be in a semi-solid state prior to application to a skin surface, can form a soft solidified layer after application, and can provide pain relief when applied to a skin surface proximate a pain site.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: March 31, 2020
    Assignee: Crescita Therapeutics Inc.
    Inventor: Jie Zhang
  • Patent number: 10603253
    Abstract: A skin care fabric for medical, pharmaceutical or cosmetic use includes at least 80% by weight of microfibers that are a mixture of polyamide and polyester and have a diameter of less than 50 microns. Each microfiber is split to produce fine fibers closely packed in a parallel structure having a capillary effect and an abrasive effect. The fabric has a surface weight of less than 180 g/m2 and is loaded with medical, pharmaceutical or cosmetic active agents. The skin care fabric includes a warp-knitted fabric having a first surface and a second surface opposite the first surface, which is mechanically roughened and cut to become fluffy and yet short-haired and compact and resulting in a further surface enlargement of the fabric structure and a water absorbency of at least four times the surface weight of the fabric.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: March 31, 2020
    Assignee: Filag Medical Schweiz AG
    Inventor: Markus Lehmann
  • Patent number: 10603218
    Abstract: A chemically modified cellulose/alginate co-spun (seacell) fiber, a wound dressing made therefrom and a preparation method thereof. The seacell fiber is subject to a chemical modification through which a hydrophilic carboxymethyl group is introduced into the cellulose structure making the chemically modified seacell fiber more absorbent. The modified cellulose has a degree of substitution of 0.05-0.5; the seacell fiber has a linear density of 0.5-5 dtex and a fiber length of 5-180 mm. The seacell fiber has hygroscopic and gel-forming properties, while retaining its active ingredient of algae particles.
    Type: Grant
    Filed: September 2, 2013
    Date of Patent: March 31, 2020
    Assignee: FOSHAN UNITED MEDICAL TECHNOLOGIES, LTD.
    Inventors: Bingzhi Tao, Xiaodong Wang
  • Patent number: 10596139
    Abstract: Pharmaceutical compositions and combinations containing a muscarinic receptor antagonist, such as oxybutynin in a transdermal therapeutic system, and a muscarinic receptor agonist, optionally with an acetyl cholinesterase inhibitor, and methods of using the same for treatment of hypocholinergic disorders of the central nervous system such as Alzheimer type dementia. The respective pharmaceutical compositions and combinations of the present invention allow for safe administration of high doses of muscarinic receptor agonist, and improved efficacy of the muscarinic receptor agonist for treatment of hypocholinergic disorders of the central nervous system. The pharmaceutical compositions and combinations also allow for a maximum supply of acetylcholine to the central nervous system, when an acetyl cholinesterase inhibitor is used in combination with a muscarinic receptor antagonist and a muscarinic receptor agonist.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: March 24, 2020
    Assignee: Chase Pharmaceuticals Corporation
    Inventors: Thomas N. Chase, Kathleen E. Clarence-Smith
  • Patent number: 10588855
    Abstract: Devices, systems, and methods for delivery of an active agent from the lens capsule to a posterior segment of the eye of a subject can include an intraocular active agent delivery device including an active agent dispersed within a biodegradable active agent matrix. The active agent includes dexamethasone and the delivery device is adapted to fit within a lens capsule or ciliary sulcus of an eye. The delivery device can be inserted into the lens capsule or ciliary sulcus of an eye during cataract surgery or for treatment of uveitis.
    Type: Grant
    Filed: December 27, 2016
    Date of Patent: March 17, 2020
    Assignee: University of Utah Research Foundation
    Inventors: Balamurali K. Ambati, Bruce K. Gale, Srinivas Rao Chennamaneni
  • Patent number: 10555887
    Abstract: The subject matter of the present invention is a sterile liquid composition dedicated to administration into or through the skin and/or the lips, wherein said composition comprises, in a physiologically acceptable medium, at least one photo-crosslinkable compound, wherein said compound comprises at least one activated photo-dimerizable group having at least one activated double bond and selected from photo-dimerizable groups carrying a stilbazolium function of formula (Ia) or (Ib) and wherein the photo-dimerizable groups carry a styrylazolium function of formula (II), the photo-dimerizable group(s) being carried by a partially or totally hydrolysed poly(vinyl acetate) polymer, a polysaccharide or a polyvinyl alcohol.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: February 11, 2020
    Assignee: L'OREAL
    Inventors: Henri Samain, Jean-Thierry Simonnet
  • Patent number: 10548924
    Abstract: Provided herein are novel methods and compositions utilizing adipose tissue-derived stromal stem cells for treating fistulae.
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: February 4, 2020
    Assignees: TIGENIX, S.A.U., UNIVERSIDAD AUTONOMA DE MADRID
    Inventors: Maria Gema Fernandez Miguel, Manuel Angel Gonzalez De La Pena, Rosa Ana Garcia Castro, Mariano Garcia Arranz, Damian Garcia-Olmo
  • Patent number: 10538662
    Abstract: A polylactic acid resin composition of the present invention is constructed by dynamically cross-linking a resin mixture containing a polylactic acid-based resin, trans-polyisoprene, and a cross-linking agent. The resin composition can be used for a wide variety of applications such as automobile molded articles, molded articles for electric products, molded articles for agricultural materials, molded articles for business use, and molded articles for daily use.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: January 21, 2020
    Assignee: HITACHI ZOSEN CORPORATION
    Inventors: Shuhei Yamaguchi, Shinya Takeno
  • Patent number: 10537532
    Abstract: Disclosed herein is a transdermal delivery system comprising methylphenidate or its salt as an active ingredient. Also provided are methods of delivering a therapeutically effective amount of methylphenidate to a subject for the treatment of a disease condition. The disease condition includes a neurological condition such as Attention Deficit Disorder (ADD) and/or Attention Deficit/Hyperactivity Disorder (ADHD). Kits including the transdermal delivery system and methods of making and using the transdermal delivery system are also provided.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: January 21, 2020
    Assignee: TAHO PHARMACEUTICALS LTD.
    Inventors: Shen-Yung Kao, Taijung Wu, Catherine Lee
  • Patent number: 10537509
    Abstract: A nail glue composition contains Beta-methoxyethyl cyanoacrylate, octyl cyanoacrylate, and polymethyl methacrylate. The nail glue composition is substantially odorless and has increased softness.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: January 21, 2020
    Inventor: Chin Hao Chang
  • Patent number: 10517946
    Abstract: Immune-polyelectrolyte multilayers (iPEMs) that can be made entirely from immune signal compounds are provided. The iPEMs are formed from first layer of a first immune signal compound, and a second layer of the first immune signal compound or a second immune signal compound disposed on the first layer of the first immune signal compound. The immune signal compounds are peptides, polypeptides, nucleic acids, charged derivatives thereof. Combinations of the immune signal compounds may be in adjacent layers. The first immune signal compound and the second immune signal compound have oppositely charged domains. iPEMs can be formed on or include a substrate, such as a sacrificial substrate, which allows for the formation of a three-dimensional void which can hold various other compounds for use in modulating immune responses. The iPEMs are for use in either stimulating an immune response to one or more antigens, or inducing tolerance to one or more antigens.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: December 31, 2019
    Assignee: University of Maryland, College Park
    Inventors: Christopher M. Jewell, Lisa H. Tostanoski, Yu-Chieh Chiu
  • Patent number: 10501868
    Abstract: An electrospinning device 1 includes an electrode 10 having a concave curved surface 11 and a needle-shaped spinning nozzle 20 surrounded by the concave curved surface 11 of the electrode 10. With an electric field applied between the electrode 10 and the nozzle 20, a spinning solution is jetted from the tip of the nozzle 20 to form a nanofiber. The nozzle 20 is located such that the direction in which the nozzle 20 extends passes through or near the center of a circle defined by the open end of the concave curved surface 11 of the electrode 10 and that the tip 20a of the nozzle 20 is positioned in or near the plane including the circle defined by the open end.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: December 10, 2019
    Assignee: KAO CORPORATION
    Inventor: Shinji Kodama
  • Patent number: 10500147
    Abstract: The present invention provides oral care compositions, and in particular toothpaste compositions comprising a calcium salt abrasive and a novel alginate-based binder and rheology modifier, together with methods of use and manufacture thereof.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: December 10, 2019
    Assignee: Colgate-Palmolive Company
    Inventors: Xiaojing Lv, Manying Shi, Zhuoxing Zhang
  • Patent number: 10495382
    Abstract: A self-contained heated wax treatment apparatus can include an outer shell and a rack disposed inside the outer shell. The rack can include a receptacle holder and at least one heater holder. A receptacle can be connected to the rack. A heater can be connected to the heater holder of the rack. Activation of the heater causes heat to flow to the receptacle.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: December 3, 2019
    Assignee: Forever Young International, Inc.
    Inventor: Daniel L. Young
  • Patent number: 10493094
    Abstract: A hemostatic putty for treatment of a variety of wounds topographies, including but not limited to highly three dimensional wounds, for example gunshot wounds and impalements, is disclosed. The putty is comprised of a matrix polymer weakly crosslinked or not crosslinked such that a viscoelastic matrix is formed. The viscoelastic nature of the putty is tunable by the composition and enables the putty to conform to a variety of wound topographies. Likewise, a hemostatic polymer, for example chitosan or hydrophobically modified chitosan, is included in this matrix to impart hemostatic properties and tissue adhesive on the putty. The hemostatic polymers disclosed prevent microbial infection and are suitable for oxygen transfer required during normal wound metabolism.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: December 3, 2019
    Assignees: GEL-E, Inc., University of Maryland, College Park, The General Hospital Corporation
    Inventors: Kevin Diehn, Matthew Dowling, Srinivasa R. Raghavan, David R. King
  • Patent number: 10478463
    Abstract: An external-use agent for cleaning and caring ovaries, vagina and vulva, which is produced by medical raw materials consisting of propolis extract, zedoary oil, and mint leaf filtrate is provided. On the basis of different properties of each natural Chinese herbal material, using supercritical CO2 technology, separation and extraction, and low-temperature centrifugation are carried out respectively, and they are processed for preparation in a proportion, and then the membrane separation is performed, so that a spraying agent or a caring product is manufactured. It may be used alone in a female reproductive system for preventing the repeated infection and for achieving vulval bacteriostatic or antibacterial purposes and cleaning and deodorizing the vagina, eliminating vulval pruritus, and refreshing and moisturizing vulva and vagina etc., with good cleaning and caring functions and achieving a significant effect.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: November 19, 2019
    Inventor: Jianxue Wei
  • Patent number: 10441614
    Abstract: The present disclosure relates, in part, to pharmaceutical compositions comprising one or more polynucleotides suitable for enhancing, increasing, augmenting, and/or supplementing the levels of Collagen alpha-1 (VII) chain polypeptide and/or Lysyl hydroxylase 3 polypeptide and/or Keratin type I cytoskeletal 17 polypeptide in a subject. The present disclosure also relates, in part, to pharmaceutical compositions and methods of use for providing prophylactic, palliative, or therapeutic relief of a wound, disorder, or disease of the skin in a subject, including a subject having, or at risk of developing, one or more symptoms of epidermolysis bullosa.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: October 15, 2019
    Assignee: Krystal Biotech, Inc.
    Inventors: Suma Krishnan, Pooja Agarwal
  • Patent number: 10420733
    Abstract: Disclosed herein is a transdermal delivery system comprising methylphenidate or its salt as an active ingredient. Also provided are methods of delivering a therapeutically effective amount of methylphenidate to a subject for the treatment of a disease condition. The disease condition includes a neurological condition such as Attention Deficit Disorder (ADD) and/or Attention Deficit/Hyperactivity Disorder (ADHD). Kits including the transdermal delivery system and methods of making and using the transdermal delivery system are also provided.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: September 24, 2019
    Assignee: TAHO PHARMACEUTICALS LTD.
    Inventors: Shen-Yung Kao, Taijung Wu, Catherine Lee
  • Patent number: 10420837
    Abstract: The present invention provides a vaccine pharmaceutical composition for transdermal administration which is safe, usable as a prophylactic or therapeutic agent for cancer or infectious diseases, and capable of safely and effectively inducing a systemic immune response.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: September 24, 2019
    Assignee: NITTO DENKO CORPORATION
    Inventors: Takuya Shishido, Daisuke Asari, Kyohei Matsushita, Katsuyuki Okubo, Mitsuhiko Hori
  • Patent number: 10420780
    Abstract: This invention provides a 25-OH Vitamin D3 complex, this complex is made of ?-cyclodextrin and/or its derivatives and 25-Hydroxy Vitamin D3. This invention also relates to a method of manufacturing this complex of ?-cyclodextrin and 25-Hydroxy Vitamin D3, as well as its applications. Due to there being many hydroxy groups at the outside of ?-cyclodextrin and/or its derivatives, the complex increases the solubility of entrapped 25-HO Vitamin D3, thus increasing its bioavailability greatly. In addition, the ring structure of ?-cyclodextrin protects the unstable unsaturated double bonds of 25-HO Vitamin D3, shield it from oxygen and other harmful chemicals and make it much more stable.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: September 24, 2019
    Assignee: RCC CORPORATION LIMITED
    Inventor: Haiyan Fan
  • Patent number: 10413595
    Abstract: Methods, compositions, and treatment protocols for treating ischemic wounds and inflammatory conditions in a patient. The treatment protocols comprise or consist of using a modified collagen gel (MCG) to promote healing of ischemic wounds and reduce inflammation at the wound site and in other inflammatory conditions. The modified collagen gel comprises generally a dispersion of collagens in an aqueous matrix comprising water and glycerine, where the amount of Type I collagen is greater than the amount of Type II and Type III collagens in the gel.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: September 17, 2019
    Assignee: Southwest Technologies, Inc.
    Inventors: Edward I. Stout, Chandan Sen
  • Patent number: 10406266
    Abstract: A system suitable for treating a tissue site may include an interface manifold, an interface sealing member, an absorbent layer, and a storage sealing member. The interface manifold may be positioned in fluid communication at the tissue site. The interface sealing member may be adapted to provide a sealed treatment space relative to the tissue site, and the interface manifold may be positioned in the sealed treatment space. The absorbent layer may be for positioning on an exterior facing side of the interface sealing member. The storage sealing member may be adapted to provide a sealed storage space between the storage sealing member and the exterior facing side of the interface sealing member. The absorbent layer may be positioned in the sealed storage space. Other systems, apparatuses, and methods are disclosed.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: September 10, 2019
    Assignee: KCI LICENSING, INC.
    Inventors: Christopher Brian Locke, Timothy Mark Robinson
  • Patent number: 10398644
    Abstract: A medicant composition is provided. The composition includes a film layer and a powder matrix layer. The powder matrix layer includes a medicant. The powder matrix layer is applied to the film layer by admixing particulate to form a powder matrix and by then applying the powder matrix to the film layer by any desired method. The composition of the powder matrix is varied to alter the dissolution rate of the medicant, the adhesion of the medicant composition, and other physical properties of the powder matrix. The powder matrix layer can be cured.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: September 3, 2019
    Assignee: CURE PHARMACEUTICAL CORPORATION
    Inventors: Robert Steven Davidson, Gary S. Kehoe
  • Patent number: 10398640
    Abstract: Beneficial topical compositions for treating scar or aging skin are provided. In one embodiment, the compositions include Bulbine frutescens, Centella asiatica and a phenol derived from olives, such as oleuropein. The composition may be used in the treatment of scars formed during surgery. The composition may also be used cosmeceutically in the treatment of aged skin, and may include phosphatidylserine, vitamins, and other beneficial anti-aging ingredients.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: September 3, 2019
    Inventor: Alan David Widgerow
  • Patent number: 10398603
    Abstract: A wound-closing dressing, which is suitable for use as part of a reduced-pressure, wound-treatment system, may include a sealing drape, one or more contracting elements, and a gripping member. The contracting element may be coupled to the sealing drape and is configured to contract when activated and to generate a closing force. A gripping member is coupled to the sealing drape and is configured to transmit the closing force to a patient's epidermis. Other dressings, systems, and methods are also disclosed.
    Type: Grant
    Filed: May 14, 2013
    Date of Patent: September 3, 2019
    Assignee: KCI Licensing, Inc.
    Inventors: Christopher Brian Locke, Timothy Mark Robinson
  • Patent number: 10391346
    Abstract: The potential for substance abuse involving residual amounts of abusable substances remaining in used skin-worn patches is reduced by the provision of a system and method for combining the abusable substance with a separate anti-abuse substance agent as part of a removal or disposal procedure.
    Type: Grant
    Filed: April 22, 2013
    Date of Patent: August 27, 2019
    Assignee: Verde Environmental Technologies, Inc.
    Inventors: Carter R. Anderson, Russell L. Morris
  • Patent number: 10383855
    Abstract: Solid dosage formulations of nitazoxanide or a nitazoxanide analog are provided that comprise a controlled release portion and an immediate release portion. The pharmaceutical composition is typically in the form of a bilayer solid oral dosage form comprising (a) a first layer comprising a first quantity of nitazoxanide or analog thereof in a controlled release formulation; and (b) a second layer comprising a second quantity of nitazoxanide or analog thereof in an immediate release formulation. Method of using the formulations in the treatment of hepatitis C are also provided.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: August 20, 2019
    Assignee: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, Marc Ayers
  • Patent number: 10376226
    Abstract: A method of in vivo monitoring the condition of an internal body repair in which an imageable, non-absorbable repair device having non-absorbable, particulate imaging material substantially uniformly dispersed therein has been surgically inserted, including: in vivo sensing of dimensional deformation of or imaging material concentration changes in said repair device during the post-surgical healing process; comparing the sensed values with a previously developed correlation between said sensed values and the values at which failure occurs of comparable repair devices; wherein said sensed values relative to the repair device's failure values, considered in conjunction with the anticipated time for complete healing of said repair, provides information as to the condition of the repair.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: August 13, 2019
    Assignee: S. Jackson, Inc.
    Inventors: Janko Jackson, Stephen L. Jackson, Crayton G. Toney
  • Patent number: 10376546
    Abstract: Described herein are compositions composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: August 13, 2019
    Assignee: MiMedx Group, Inc.
    Inventors: Brenda S. Morse, Somaly Sith, Randall Spencer, Steven Ray, John Daniel, Robert Tofe
  • Patent number: 10376418
    Abstract: A bandage includes a body and an adhesive layer. An attachment portion is defined by exposing the adhesive layer. The bandage includes a first removable dressing component having a predetermined length and width carried by the adhesive layer disposed over the central axis of the body. A second removable dressing component having a predetermined length and width is also carried by the adhesive layer. The respective widths of the first and second removable dressing components being less than the width of the body enabling a side edge attachment portion to be defined proximate the side edges of the body and wherein the removal of the first removable dressing component exposes the adhesive layer defining an end attachment portion of the bandage.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: August 13, 2019
    Inventor: Daniel E Selton
  • Patent number: 10369142
    Abstract: The invention provides a solid composition of the peripheral mu opioid antagonist axelopran and a combination dosage form of the mu opioid antagonist axelopran sulfate in an immediate release form and an opioid analgesic agent which may be in an extended release, sustained release, modified release, or controlled release form and methods of preparing such a combination dosage form.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: August 6, 2019
    Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Shaoling Li, Manshiu Leung, Hao Zhang, Venkat R. Thalladi, Yun Mo
  • Patent number: 10357592
    Abstract: The present invention provides a process or preparing an extracellular matrix composition which comprises: (a) mixing an aqueous solution of fibrinogen with a coagulating agent and a bulking agent and a foaming agent; (b) causing the mixture to foam and coagulate; (c) incubating the mixture obtained in step (b) with a cross-linking agent; and (d) washing the cross-linked composition obtained in step (c) to remove the cross-linking agent. Wherein the foaming agent consists of or comprises one or more surfactant agent(s) from the class of sugar-surfactants. The invention also relates to the formulation mixture as such, and to the products of the process.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: July 23, 2019
    Assignee: SMART MATRIX INTELLECTUAL PROPERTY LIMITED
    Inventors: Julian F. Dye, Vaibhav Sharma, Elena Garcia-Gareta, Keith Alan Blackwood
  • Patent number: 10350180
    Abstract: Solid-forming local anesthetic formulations for pain control can include a lidocaine base and tetracaine base, polyvinyl alcohol, water, and an emulsifier. The formulation can be prepared to be in a semi-solid state prior to application to a skin surface, can form a soft solidified layer after application, and can provide pain relief when applied to a skin surface proximate a pain site.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: July 16, 2019
    Assignee: Crescita Therapeutics Inc.
    Inventor: Jie Zhang
  • Patent number: 10316470
    Abstract: To provide tissue paper with an excellent “moist texture” and high “smooth texture.” 2-ply tissue paper is characterized by the basis weight per ply being 15 to 18 g/m2, the 2-ply paper thickness being 135 to 160 ?m, and containing 2.9 g/m2 or more and 8.0 g/m2 or less of chemical agent which contains glycerin and 1,3-propanediol in a total amount of 83.7 mass % or more, wherein the mass ratio of glycerin and 1,3-propanediol is 1:0.04 or more and 1:5.58 or less.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: June 11, 2019
    Assignee: Daio Paper Corporation
    Inventor: Shuta Yasui
  • Patent number: 10316228
    Abstract: A multi-phase silicone acrylic hybrid visco-elastic composition prepared by polymerizing an ethylenically unsaturated monomer and a silicon-containing pressure sensitive adhesive composition comprising acrylate or methacrylate functionality in a first solvent in the presence of an initiator, removing the first solvent, and adding a second solvent to form the multi-phase silicone acrylic hybrid visco-elastic composition. Alternatively, a multi-phase silicone acrylic hybrid visco-elastic composition prepared by polymerizing an ethylenically unsaturated monomer and a silicon-containing pressure sensitive adhesive composition comprising acrylate or methacrylate functionality in a first solvent in the presence of an initiator, adding a processing solvent having a higher boiling point than the first solvent, applying heat to selectively remove a majority of the first solvent, removing the processing solvent, and adding a second solvent to form the multi-phase silicone acrylic hybrid visco-elastic composition.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: June 11, 2019
    Assignee: DOW SILICONES CORPORATION
    Inventors: Chana Wilson Evans, Robert O. Huber, Linda S. Nartker, Gerald K. Schalau, II, Xavier Thomas, Simon Toth
  • Patent number: 10300136
    Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: May 28, 2019
    Assignees: Massachusetts Institute of Technology, Tokitae LLC
    Inventors: Ana Jaklenec, William Gates, Philip A. Welkhoff, Boris Nikolic, Lowell L. Wood, Robert S. Langer, Thanh Duc Nguyen, Stephany Yi Tzeng, James J. Norman, Kevin McHugh
  • Patent number: 10285794
    Abstract: An improved abdominal hernia repair system is presented comprised of a silicone layer backed up with a knitted or woven polypropylene fabric layer, the silicone layer possessing a regular pattern of slits that permit equilibration of fluid pressure across the device. A variety of therapeutic substances can be applied to the hernia repair device to promote healing, including aloe and other medicinal preparations. A layer of water soluble or water insoluble anti-scar compound is also present, the preferred compound being Salinomycin. An improved inguinal hernia repair system is presented that is identical to the above except it does not contain the hydrophobic silicone component.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: May 14, 2019
    Inventors: E. Aubrey Woodroof, Richard P. Phipps, Collyn F. Woeller, Lipton Laverne Martin
  • Patent number: 10258610
    Abstract: The invention relates generally to pharmaceutical compositions comprising rifaximin effective at treating vaginal infections, and in particular bacterial vaginosis. The pharmaceutical compositions comprising rifaximin granules are characterized in that they release rifaximin in the vagina in a controlled way. The present invention also relates to processes for preparation of the rifaximin pharmaceutical compositions and their use in the treatment of vaginal infections. Effective dosages and courses of treatment useful and effective at recovering from the disease and preventing any possible relapse are also provided.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: April 16, 2019
    Assignee: ALFASIGMA S.P.A.
    Inventors: Giuseppe Claudio Viscomi, Paola Maffei, Vittoria Lauro, Fiorella Calanni, Beatrice Vitali, Federica Cruciani
  • Patent number: 10253213
    Abstract: The present invention relates to a method for coating an inert or naturally occurring material with a silk polypeptide. It further relates to a coated inert or naturally occurring material obtainable by said method and to uses thereof. It also relates to products comprising said coated material.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: April 9, 2019
    Assignee: Amsilk GmbH
    Inventors: Axel H. Leimer, Lin Romer