Dressings Patents (Class 424/445)
  • Patent number: 11911448
    Abstract: The present invention provides methods for large scale preparation of sterile stable liquid thrombin composition comprised of glycerol; stable liquid thrombin compositions; and hemostatic composition and kits. The present invention further provides hemostatic compositions comprised of liquid thrombin, glycerol and gelatin. Further provided herein is a method for the large-scale production of a sterile liquid thrombin composition comprised of glycerol.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: February 27, 2024
    Assignee: Omrix Biopharmaceuticals Ltd.
    Inventors: Erez Ilan, Omri Faingold, Sivan Doron
  • Patent number: 11903961
    Abstract: A composition and method of preparing the composition for rapid and effective hemostasis is provided. The composition includes a first agent to induce platelet plug formation, a second to induce vasoconstriction and a third agent for activation of coagulation cascade. The composition comprises of 0.01% to 5% of chitosan; 0.01% to 0.25% of potassium aluminum sulphate; and 0.01% to 0.25% calcium salt. The clotting time of the composition is in the range of 30s to 140s. A method of preparing the hemostatic composition is further disclosed. The composition is configured to control hemorrhage from oozing and pressured bleeding injury any site in human/animal body.
    Type: Grant
    Filed: August 17, 2021
    Date of Patent: February 20, 2024
    Assignee: Amrita Vishwa Vidyapeetham
    Inventors: Jayakumar Rangasamy, Nivedhitha Muthiahpillai Sundaram, Ullas Mony, Praveen Kerala Varma
  • Patent number: 11885735
    Abstract: The present is directed to systems for ex vivo testing performance of a hemostatic or sealing product attached to an animal organ and fully covering a cored channel in said organ, comprising: a pressure sensor positioned proximate to said hemostatic or sealing product in said cored channel; a monitoring or recording device configured to receive pressure readings from said pressure sensor; and a pressurized fluid source connected to said cored channel and configured to supply said pressurized fluid into said cored channel under constant or variable pressure. The present invention is also directed to methods of use for such systems.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: January 30, 2024
    Assignee: Ethicon, Inc.
    Inventors: John Matonick, Kevin Hengst, Matthew Pfefferkorn, Robert J. Tannhauser, Leo B. Kriksunov
  • Patent number: 11624151
    Abstract: A textile includes a substrate and a coating applied to a surface of the substrate. The coating includes a plurality of bilayers positioned one on top of the other. Each bilayer includes a first layer including a cationic polymer and a second layer comprising an anionic polymer. The cationic polymer in the first layer includes a polyethyleneimine (PEI), a poly(vinyl amine) (PVAm), a poly(allyl amine) (PAAm), a polydiallyldimethylammonium chloride (PDDA), or a chitosan (CH). The anionic polymer in the second layer includes a poly(acrylic acid) (PAA), a poly(styrene sulfonate) (PSS), a poly(methacrylic acid) (PMAA), a poly(sodium phosphate) (PSP), or a poly(vinyl sulfate) (PVS).
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: April 11, 2023
    Inventors: Jaime Christopher Grunlan, Ryan J. Smith
  • Patent number: 11504033
    Abstract: Polyurethane material for indicating pH at a locus, preferably as indication of presence of microbes, comprising a polyurethane network having immobilised therein one or more hydrophilic copolymers, the or each said copolymer comprising: hydrophilic monomer; and indicating monomer, which provides an indication in response to a change in hydrophilic state of said hydrophilic monomer and/or copolymer; characterised in that the or each copolymer further comprises one or a plurality of ionisable groups or moieties or polymerisable monomers having one or more characteristic pKa values in the range 5 to 10 and which are responsive to pH at the locus in the range pH 5 to pH 10 and in that hydrophilic state of hydrophilic copolymer is dependent on ionisation of said ionisable groups, moieties or monomers; kit and device comprising the material and process for preparation thereof; and use in detecting or sensing microbes or pH.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: November 22, 2022
    Assignees: Smith & Nephew PLC, University of Sheffield
    Inventors: John Kenneth Hicks, Richard Hoskins, Stephen Rimmer, Dorothy McCulloch
  • Patent number: 11484623
    Abstract: The present invention is directed to a dry pad comprising pectin, a divalent cation and thrombin and to its preparation. Preferably, the density of pectin in the dry pad of the invention ranges from about equal to or higher than 1% to lower than 7% (w/v). The pad according to the invention comprises pectin having a low methoxyl content.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: November 1, 2022
    Assignee: Omrix Biopharmaceuticals Ltd.
    Inventors: Erez Ilan, Yotam Gurman, Ronen Eavri, Elya Dekel
  • Patent number: 11485772
    Abstract: The present invention provides a modified collagen comprising S-nitroso groups and a method of manufacture of such a modified collagen. Also provided is a wound dressing comprising such a modified collagen, particularly a wound dressing comprising a formulated composition comprising such a modified collagen.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: November 1, 2022
    Inventor: Andrew Mearns Spragg
  • Patent number: 11452795
    Abstract: Provided are a medical lubricating member including a silicone base material, and a lubricating coated film which is laminated on at least one surface of the silicone base material, in which the silicone base material contains a reactive functional group in the surface on which the lubricating coated film is laminated, and the lubricating coated film is a film formed of a composition containing a hydrophilic polymer and polyisocyanate; a medical device using the medical lubricating member; and a method of producing the medical lubricating member.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: September 27, 2022
    Assignee: FUJIFILM Corporation
    Inventors: Toshihide Yoshitani, Nobuharu Takahashi
  • Patent number: 11426483
    Abstract: The invention provides a wound dressing made by an ex vivo formed combination of fibrinogen and/or fibrin containing-liquid formulation and an oxidized cellulose (OC) backing; and use thereof.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: August 30, 2022
    Assignee: Omrix Biopharmaceuticals Ltd.
    Inventors: Erez Ilan, Omri Faingold
  • Patent number: 11389421
    Abstract: The present invention relates to a transdermal therapeutic system (TTS) for the transdermal administration of rivastigmine comprising a rivastigmine-containing layer structure, said rivastigmine-containing layer structure comprising: A) a backing layer; and B) a rivastigmine-containing layer.
    Type: Grant
    Filed: September 4, 2018
    Date of Patent: July 19, 2022
    Inventors: Marco Emgenbroich, Nico Reum, Jessica Verstraelen, Regine Kaufmann
  • Patent number: 11389561
    Abstract: The inventive subject matter provides kits, compositions and methods for treating or covering skin using a polymerizable formulation. The polymerizable formulation can include a first component including a siloxane polymer and a catalyst, and a second component including a siloxane polymer and a cross-linker. The first and second components, when combined, can form a film or seal having an elasticity that at least one of decreases the formation of fibroblasts, presses down blisters, decreases a biochemical cascade that promotes scar formation, compresses skin, and holds skin in a desired configuration.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: July 19, 2022
    Inventor: Shien-Lin Saber
  • Patent number: 11383484
    Abstract: A composite material (and its manufacture) is described that has (i) a first layer comprising an absorbent fiber material that is in contact with the area of use on its first side, (ii) a second layer comprising an absorbent material, said second layer being arranged on the second side of said first layer, wherein a plurality of channels extends through the entire first layer, from said first side to said second side thereof, and further extends into at least a portion of said second layer. This composite is of particular use in wound treatment.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: July 12, 2022
    Assignee: Mölnlycke Health Care AB
    Inventor: Erik Carlsson
  • Patent number: 11304852
    Abstract: The present invention is directed to a hemostatic textile, comprising: a material comprising a combination of glass fibers and one or more secondary fibers selected from the group consisting of silk fibers; ceramic fibers; raw or regenerated bamboo fibers; cotton fibers; rayon fibers; linen fibers; ramie fibers; jute fibers; sisal fibers; flax fibers; soybean fibers; corn fibers; hemp fibers; lyocel fibers; wool; lactide and/or glycolide polymers; lactide/glycolide copolymers; silicate fibers; polyimide fibers; feldspar fibers; zeolite fibers, zeolite-containing fibers, acetate fibers; and combinations thereof; the hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. Additional cofactors such as thrombin and hemostatic agents such as RL platelets, RL blood cells; fibrin, fibrinogen, and combinations thereof may also be incorporated into the textile. The invention is also directed to methods of producing the textile, and methods of using the textile to stop bleeding.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: April 19, 2022
    Inventors: Thomas H. Fischer, E. Stan Eskridge, William M. Malloy, Malloy Evans
  • Patent number: 11299630
    Abstract: The present invention relates to a biomaterial fabrication process for the manufacture of a collagen based fabric for an aligned collagen fiber network.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: April 12, 2022
    Assignee: 3DBIOFIBR INC.
    Inventor: John Paul Frampton, IV
  • Patent number: 11241484
    Abstract: The present invention relates to pharmaceutical compositions comprising collagen and hyaluronic acid, and optionally containing silver. Said compositions may be in the form of a hydrogel, pad or dry spray. The invention also relates to the preparation process of said compositions in pad form. Finally, the invention relates to the use of the compositions for the treatment of skin lesions.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: February 8, 2022
    Inventors: Giovanni Gennari, Susi Panfilo, Juan Francisco Scalesciani
  • Patent number: 11174460
    Abstract: Efficient stem cell delivery into biomaterials using capillary driven encapsulation are disclosed herein where stem/progenitor and/or tissue specific cells are rapidly and efficiently seeded via capillary driven encapsulation into a porous scaffold for cell delivery in the skin or any other organ. The rapid capillary force approach maximizes both seeding time and efficiency by combining hydrophobic, entropic and capillary forces to promote active, ‘bottom-up’ cell engraftment. This methodology uses micro domain patterned biopolymers in a porous dry gel to generate capillary pressure to move a viscous stem cell mix from a hydrophobic reservoir into the polymer matrix to promote active cell seeding within the entire gel volume.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: November 16, 2021
    Inventors: Geoffrey C. Gurtner, Jayakumar Rajadas, Robert C. Rennert
  • Patent number: 11173071
    Abstract: A periocular dressing includes a base layer composed of a nonwoven material; a top layer having a composition bound to a polyurethane film, the composition including a hydrogel with a percentage by weight of bacitracin, the top layer to come into contact with a user's skin; and a removable membrane secured over the top layer and to be removed; the polyurethane film of the top layer is adhesively secured to the base layer; and the top layer promotes vasoconstriction and antibacterial properties.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: November 16, 2021
    Inventors: Ahmad H. Tawil, Ronald Mancini
  • Patent number: 11167058
    Abstract: Compositions comprising clay minerals and methods for their use in promoting hemostasis are provided. The compositions comprise clay minerals such as bentonite, and facilitate blood clotting when applied to a hemorrhaging wound. Electrospun or electrosprayed materials (e.g. bandages, micron beads, etc.) which include clay minerals, and methods for the treatment of acute hemorrhage, are also provided.
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: November 9, 2021
    Inventors: Robert F. Diegelmann, Kevin R. Ward, Marcus E. Carr, Gary Lee Bowlin
  • Patent number: 11083824
    Abstract: The present invention discloses a compound heparin anticoagulant coating liquid, a microsphere for coating and its preparation methods and applications. In the present invention, the combination of curcumin and heparin can enhance the anticoagulation functions of heparin coating, and further enhance the stability using the properties of PLA-PEG-PLA drug-loaded sustained-release microspheres, achieving the functions of anti-tissue proliferation and anti-inflammatory reactions that cannot be achieved by coatings alone such as heparin or protein, which is very important for implanted devices such as artificial blood vessels, vascular stents and vascular patches to reduce thrombosis in the human body, lower postoperative complications and improve product lifespan.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: August 10, 2021
    Inventors: Tuo Yan, Chenxi Ouyang, Yawen Liu, Sishi Liu, Yuan Liu
  • Patent number: 11083822
    Abstract: Combination cellulose materials and methods of making and using these materials. The combination material includes a first cellulosic material and a second cellulosic material.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: August 10, 2021
    Assignee: Ethicon, Inc.
    Inventors: Daniel J. Smith, Christophe Vailhe
  • Patent number: 11033580
    Abstract: Disclosed are antimicrobial silicone substances, which are obtained by using multifunctional cellulose/silver and silicon matrix nanocomposites. Using environmentally friendly, simple deposition techniques, Ag particles were deposited on cellulose. Silicone was filled with the obtained composites of cellulose and silver particles. The created modified cellulose/silver and silicone composite is characterized by good physical and chemical properties, as well as strong antimicrobial effect on both Gram- positive and Gram-negative bacteria.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: June 15, 2021
    Assignee: Kauno Technologijos Universitetas
    Inventors: Virginija Jankauskaite, Aisté Lisauskaite
  • Patent number: 11001735
    Abstract: A water-based dispersion adhesive composition and use thereof for bonding floor coverings or for bonding wood floors to substrates. The water-based dispersion adhesive composition includes an aqueous polymer dispersion including water and at least one water-dispersible polymer, at least one calcium ion complexing agent, at least one calcium ion precipitating agent, and at least one calcium-containing filler.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: May 11, 2021
    Inventors: Yvonne Giesing, Bernd Overkamp, Tobias Benighaus
  • Patent number: 10987447
    Abstract: The present invention relates to an antibacterial dressing and a method for preparing the same. According to the present invention, there are provided an antibacterial dressing containing a rapid cell membrane-penetrating component that exhibits excellent bactericidal and antibacterial activities by disrupting the structure and synthesis of protein and nucleic acid, and a method for preparing the same.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: April 27, 2021
    Assignee: Genewel Co., Ltd.
    Inventors: Hyun Jung Kim, Il Kyu Park, Seung Moon Lee, Yong Soo Kim
  • Patent number: 10953130
    Abstract: A solid hemostatic composition for use within a biological tissue at an internal treatment site includes a biopolymer configured to cross-link with red blood cells at the site to facilitate clot formation at the site, a first thickener that includes (hydroxypropyl)methyl cellulose (HPMC), a second thickener that includes animal-derived gelatin, and a bioadhesive that includes a low molecular weight poly(lactide).
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: March 23, 2021
    Inventor: Victor Matthew Phillips
  • Patent number: 10905712
    Abstract: The present invention relates to a liquid nitric oxide releasing solution (NORS) comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of nitric oxide gas (gNO). The present invention also relates to a liquid NORS comprised of at least one nitrite compound having a concentration of no greater than about 0.5% w/v and at least one acidifying agent, wherein the NORS releases a therapeutically effective amount of gNO. The present invention also relates to a method for the treatment of a wound in a human, the method comprising administering to the human a liquid NORS comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of gNO.
    Type: Grant
    Filed: August 13, 2017
    Date of Patent: February 2, 2021
    Assignee: SaNOtize Research and Development Corp.
    Inventors: Alex Stenzler, Christopher C. Miller, Gilly Regev-Shoshani
  • Patent number: 10806819
    Abstract: A wound covering is provided that comprises a substrate and vitamin D, or analogues or metabolites thereof, embedded in the substrate. Methods of making a wound covering are also provided and include the steps of providing a solution that includes a polymer; adding vitamin D, or analogues or metabolites thereof, to the solution to form a mixture; and forming one or more fibers from the mixture that are then embedded with the vitamin D, or analogues or metabolites thereof. Methods of treating a subject are further provided and include the step of applying a wound covering including one or more fibers embedded with vitamin D, or analogues or metabolites thereof, to a site on a subject.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: October 20, 2020
    Inventor: Franklin D. Shuler
  • Patent number: 10772767
    Abstract: A fibrin-coated wound dressing article having a flexible film layer, a pressure-sensitive adhesive layer disposed on the flexible film layer, and a fibrin powder layer disposed on a surface of the pressure-sensitive adhesive layer opposite the flexible film layer. Methods of making and using fibrin-coated wound dressing articles are included.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: September 15, 2020
    Assignee: 3M Innovative Properties Company
    Inventors: Jason W. Bjork, Kurt J. Halverson, Alexi J. Young, Stephanie J. Moeller
  • Patent number: 10731145
    Abstract: Device, and methods of using or making the device, for engineering cells in vitro are disclosed. In some aspects, a cell culture device comprises at least one glass or polymer surface configured for incubating cells in a culture medium; a charged molecule electrostatically bound to the surface; and a polyelectrolyte multilayer (PEM) electrostatically bound to the charged molecule, the PEM comprising one or more bi-layers of oppositely charged polyelectrolytes, and the PEM having a sufficient thickness to permit release of the charged molecule into the culture medium in a controlled released manner.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: August 4, 2020
    Assignee: Worcester Polytechnic Institute
    Inventors: Amy Peterson, Marsha Rolle, Ivan Ding
  • Patent number: 10722493
    Abstract: Methods of treating fibroproliferative disorders mediated by ?-catenin in mammals, including aggressive fibromatoses, also called desmoid tumour.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: July 28, 2020
    Assignee: The Hospital for Special Children
    Inventors: Benjamin A. Alman, Raymond Poon, Helen Hong, Gene Gauzer
  • Patent number: 10703942
    Abstract: Low cytotoxicity compositions are disclosed, most particularly for use in adhesive medical products such as wound dressings (100) and medical skin coverings including surgical incision drapes, bacterial barriers without a wound pad for covering wounds and skin closure products. Methods of treatment are also disclosed that use the adhesive medical products, for example on patients with an injury or a long-term medical condition requiring repeated application of dressings, on patients undergoing surgery, on patients after surgery and/or injury requiring a skin covering, and skin closure methods.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: July 7, 2020
    Inventor: Mats Tunius
  • Patent number: 10703853
    Abstract: A cross-linker composition, a resin composition, a curable composition, a method of making thereof, and articles produced therefrom are provided. The cross-linker composition can be formed from by contacting a diethanolamine with a dialkylsquarate to form the cross-linker composition. The resin composition can be formed by contacting the cross-linker composition with an isocyanate. The curable composition can be formed by contacting the resin composition with an amine.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: July 7, 2020
    Inventors: Igor Pochorovski, Alan Ekin
  • Patent number: 10624919
    Abstract: A dietary supplement composition is formulated in a therapeutic amount to treat and alleviate symptoms of joint pain. The composition includes pro-inflammatory low molecular weight microbial fermented sodium hyaluronate fragments having a molecular weight of 0.5 to 300 kilodaltons (kDa) in an oral dosage form.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: April 21, 2020
    Inventors: John A. Minatelli, W. Stephen Hill, Rudi E. Moerck
  • Patent number: 10603401
    Abstract: The present invention relates to skin dressings that are useful in the treatment of conditions associated with tissue ischaemia and skin lesions including those that are infected, such as burns and surgical wounds and chronic wounds such as but not limited5 to diabetic foot ulcers and venous leg ulcers. The skin dressings are also useful to effect transdermal delivery of pharmaceutically active agents.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: March 31, 2020
    Assignees: Edixomed Limited, First Water Limited
    Inventors: Hugh Munro, Nicholas Boote
  • Patent number: 10570390
    Abstract: Compositions, devices, and methods for treating infections.
    Type: Grant
    Filed: August 20, 2012
    Date of Patent: February 25, 2020
    Inventors: Rodney J. Y. Ho, Brenda Newman
  • Patent number: 10568771
    Abstract: A wound dressing system that includes a conformal cover and an infusion pump is provided. The cover includes a fluid port and an oxygen catalyst. The infusion pump is configured to deliver a bioactive liquid to the cover via the fluid port. The liquid includes an oxygen precursor. Upon combination, the oxygen catalyst and precursor react to form oxygen. A method of applying a wound dressing system including a bioactive powder, a bioactive liquid, and a conformal cover to a wound site is also provided. The method includes applying the powder to the wound site; securing the cover around the wound site, where the cover includes an oxygen catalyst and a fluid port; and delivering the bioactive liquid to at least an inner layer of the cover via the fluid port, where the bioactive liquid includes an oxygen precursor.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: February 25, 2020
    Assignee: Avent, Inc.
    Inventors: John Gavin MacDonald, Ramanathan S. Lalgudi, Karien J. Rodriguez, Reade Harpham, Stephanie Kute, Alison Salyer Bagwell, Brian Joseph Cuevas
  • Patent number: 10548978
    Abstract: A microcapsule encapsulates a payload agent, the microcapsule having a microcapsule shell material that is rupturable (e.g., to release the encapsulated payload agent) via a retro-dimerization reaction.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: February 4, 2020
    Assignee: International Business Machines Corporation
    Inventors: Scott B. King, Brandon M. Kobilka, Joseph Kuczynski, Jason T. Wertz
  • Patent number: 10543476
    Abstract: Disclosed herein is a porous material comprising a biopolymer functionalized with a carbon dioxide capturing moiety; where the biopolymer is in the form of a foam or an aerogel having a bulk density of 500 grams per cubic meter to 2500 grams per cubic meter. Disclosed herein too is a method comprising functionalizing a biopolymer with a carbon dioxide capturing moiety; dissolving the biopolymer in an aqueous solution to form a first solution; reducing the temperature of the first solution to below the freezing point of the aqueous solution; displacing the aqueous solution with a first solvent that has a lower surface tension than a surface tension of the aqueous solution; and drying the first solvent to produce a porous biopolymer having a bulk density of 500 grams per cubic meter to 2500 grams per cubic meter.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: January 28, 2020
    Inventors: Yinyong Li, Kenneth Raymond Carter, Kara Martin
  • Patent number: 10537659
    Abstract: A medical device comprising a structure formed of polyvinyl alcohol.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: January 21, 2020
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Jonathan Steven Alexander, Christen J. Boyer
  • Patent number: 10485891
    Abstract: Systems, methods, and apparatuses for forming a multi-function core for a dressing are described. The multi-function core includes a contact layer configured to be positioned adjacent to a tissue site, a wicking layer adjacent to the contact layer, an ion exchange layer adjacent to the wicking layer, an absorbing layer adjacent to the ion exchange layer, a blocking layer adjacent to the absorbing layer, and an odor-absorbing layer adjacent to the blocking layer. The contact layer, the wicking layer, the ion exchange layer, the absorbing layer, the blocking layer, and the odor-absorbing layer are coextensive and formed from a plurality of fibers disposed in a fibrous web. Methods of manufacturing the multi-function core are also described.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: November 26, 2019
    Assignee: KCI Licensing, Inc.
    Inventors: Brian Andrews, Timothy Mark Robinson, Christopher Brian Locke, David George Whyte
  • Patent number: 10470771
    Abstract: The present disclosure provides annular support structures for use in conjunction with stapling devices. These annular support structures may be suitable for reducing occurrences of leaking, bleeding and/or stricture, as well as anastomotic tension, when anastomosing various body structures.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: November 12, 2019
    Assignee: Covidien LP
    Inventors: William D'Agostino, Michael Bettuchi
  • Patent number: 10426670
    Abstract: The invention relates to a wound dressing which is particularly suited for therapeutically dressing wounds. Said wound dressing comprises at least one air permeable layer having a porous and/or foam-based structure, particularly in the form of a solid foam (“foam layer”), and at least one sorbent in the form of activated carbon.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: October 1, 2019
    Assignee: Blücher GmbH
    Inventors: Hasso von Blücher, Raik Schönfeld, Frank Pallaske
  • Patent number: 10350045
    Abstract: A repair material with multi-purpose for an abdominal wall hernia of the present invention relates to a technical field of medical consumables, which includes technical field of medical consumables. In the MPEG-PLLA copolymer, a molecular weight of MPEG is 2000-10000, and a molecular weight of PLLA is 3000-8000. Compared with PLCL, the repair material of the present invention is significantly improved in water absorption of the absorbable membrane to ameliorate healing effects, and a contact angle is greatly reduced. As a result, postoperative abdominal wall compliance is sufficient, which basically provides no discomfort. Therefore, compared with the PLCL, the present invention is more comfortable. In addition, the repair material of the present invention doesn't need to be heat-fitted, and polypropylene is completely fitted with the absorbable membrane, wherein no obvious boundary face is observed through a microscope, and separation never occurred.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: July 16, 2019
    Assignee: TransEasy Medical Tech.Co., Ltd
    Inventors: Jie Sun, Fan Chen, Hongying Qiao, Lingcui Ding, Kai Meng
  • Patent number: 10300182
    Abstract: A wound care device includes a flexible cover having a concave interior surface and a flange configured for sealing engagement with the skin of a patient so that the device can be affixed to the skin of the patient. An inlet tube is in fluid communication with the interior thereof and configured to deliver a fluid compound thereto. An outlet tube extends from the flexible cover and is in fluid communication with the interior thereof to allow aspiration of fluid from within the flexible cover. A programmable system delivers one or more of oxygen, saline, medicaments, UV light, and ultrasonic vibration on a schedule predetermined by a user of the device.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: May 28, 2019
    Inventor: Harjeet S Brar
  • Patent number: 10279072
    Abstract: Body tissue and structures in an airway may be treated with an artificial scab comprising an inhomogeneous, uncohesive, solid sheet-like body comprising a granular mixture of chitosan and polysaccharide particles. The artificial scab breaks apart into smaller pieces if peeled away from the surgical site or wound, thus reducing the risk of airway occlusion.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: May 7, 2019
    Assignee: Medtronic, Inc.
    Inventors: James B. Hissong, Matthew F. Myntti, Jennifer G. Medina
  • Patent number: 10265438
    Abstract: A biological construct for the repair and replacement of damaged connective tissue is provided. Methods of repairing or otherwise replacing connective tissue are also provided.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: April 23, 2019
    Assignee: BioDlogics, LLC
    Inventor: Timothy R. Brahm
  • Patent number: 10239856
    Abstract: Disclosed are macrocyclic compounds of formulae I, I?, II, II?, III, III?, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: March 26, 2019
    Inventors: Nicolas Winssinger, Sofia Barluenga, Martin Karplus
  • Patent number: 10213344
    Abstract: A medical dressing includes an adhesive, permeable layer, a fabric support, and a hydrochromatic layer. The adhesive, permeable layer is configured to adhere to skin near a wound, for example, an intravenous catheter or other percutaneous device insertion site. The fabric support is disposed on the adhesive, permeable layer. The hydrochromatic layer is disposed on the fabric support, and is configured to change a color appearance responsive to contact with moisture.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: February 26, 2019
    Assignee: Availtek LLC
    Inventors: Terri L. Bogue, Robert L. Bogue
  • Patent number: 10195556
    Abstract: A laminated nonwoven fabric includes a first nonwoven fabric containing first fibers, a second nonwoven fabric containing second fibers, a third nonwoven fabric containing third fibers, and an adhesive. The second nonwoven fabric is laminated on the first nonwoven fabric, and the third nonwoven fabric is laminated on the second nonwoven fabric on an opposite side with respect to the first nonwoven fabric. The adhesive is disposed between the first nonwoven fabric and the third nonwoven fabric. An average fiber diameter of the second fibers is equal to or less than 3 ?m, and is smaller than an average fiber diameter of the first fibers. The third nonwoven fabric has a protrusion including a part of the third fibers entangled with each other on a surface facing the second nonwoven fabric. At least a part of the adhesive is disposed between the protrusion and the first nonwoven fabric.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: February 5, 2019
    Inventors: Koji Motomura, Takahiko Murata, Hiroto Sumida, Takatoshi Mitsushima, Keiji Fujiwara
  • Patent number: 10131794
    Abstract: The present invention provides for a household, agricultural, coating or personal care product composition containing the crosslinked reaction product of a network composition the reaction product of: (i) at least one anionic polymerizable ethylenically unsaturated monomer (I) selected from the group consisting of [CH2?C(R3)C(O)OXa(C2H4O)b(C3H6O)c(C4H8O)d]pP(O)(OY)q(OZ)r and CH2?C(R3)C(O)OXa?(C2H4O)b?(C3H6O)c?(C4H8O)d?—SO3—Y) where R3=H or alkyl of 1 to about 6 carbon atoms; X=alkyl, aryl, or alkaryl diradical connecting group of 0 to about 9 carbon atoms; a, a?, b, b?, c, c?, d and d? are 0 to about 100; q is 0 to about 2; r is 0 to about 2; p is 1 to about 3 subject to the limitation that p+q+r=3; and Y and Z is H, or metal ion; and (ii) one or more additional monomers (II) selected from the group consisting of acrylic acid/acrylate, methacrylic acid/methacrylate, acrylamides, vinyl acetate and styrene, which are copolymerizable with (I); and (iii) a cross-linking agent (III), capable of copolymerizin
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: November 20, 2018
    Assignee: Momentive Performance Materials Inc.
    Inventors: Ning Lu, Sigfredo Gonzalez, Ernie Silvestre, Geng Wang
  • Patent number: 10124064
    Abstract: Pharmaceutical compositions comprising an aminoglycosidic antibiotic and at least one zinc-chelating agent in a specified concentration, and methods of inhibiting bacterial colonization, biofilm formation and if treating bacterial infections utilizing the compositions are provided. Topical formulations suitable for wound care, and surface-applicable formulations suitable for medical, industrial and household disinfecting needs are also described.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: November 13, 2018
    Assignee: University of Cincinnati
    Inventors: Andrew B. Herr, Gary Young