Dressings Patents (Class 424/445)
  • Patent number: 10722493
    Abstract: Methods of treating fibroproliferative disorders mediated by ?-catenin in mammals, including aggressive fibromatoses, also called desmoid tumour.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: July 28, 2020
    Assignee: The Hospital for Special Children
    Inventors: Benjamin A. Alman, Raymond Poon, Helen Hong, Gene Gauzer
  • Patent number: 10703942
    Abstract: Low cytotoxicity compositions are disclosed, most particularly for use in adhesive medical products such as wound dressings (100) and medical skin coverings including surgical incision drapes, bacterial barriers without a wound pad for covering wounds and skin closure products. Methods of treatment are also disclosed that use the adhesive medical products, for example on patients with an injury or a long-term medical condition requiring repeated application of dressings, on patients undergoing surgery, on patients after surgery and/or injury requiring a skin covering, and skin closure methods.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: July 7, 2020
    Assignee: LUMINA ADHESIVES AB
    Inventor: Mats Tunius
  • Patent number: 10703853
    Abstract: A cross-linker composition, a resin composition, a curable composition, a method of making thereof, and articles produced therefrom are provided. The cross-linker composition can be formed from by contacting a diethanolamine with a dialkylsquarate to form the cross-linker composition. The resin composition can be formed by contacting the cross-linker composition with an isocyanate. The curable composition can be formed by contacting the resin composition with an amine.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: July 7, 2020
    Assignees: COVESTRO DEUTSCHLAND AG, COVESTRO LLC
    Inventors: Igor Pochorovski, Alan Ekin
  • Patent number: 10624919
    Abstract: A dietary supplement composition is formulated in a therapeutic amount to treat and alleviate symptoms of joint pain. The composition includes pro-inflammatory low molecular weight microbial fermented sodium hyaluronate fragments having a molecular weight of 0.5 to 300 kilodaltons (kDa) in an oral dosage form.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: April 21, 2020
    Assignee: U.S. NUTRACEUTICALS, LLC
    Inventors: John A. Minatelli, W. Stephen Hill, Rudi E. Moerck
  • Patent number: 10603401
    Abstract: The present invention relates to skin dressings that are useful in the treatment of conditions associated with tissue ischaemia and skin lesions including those that are infected, such as burns and surgical wounds and chronic wounds such as but not limited5 to diabetic foot ulcers and venous leg ulcers. The skin dressings are also useful to effect transdermal delivery of pharmaceutically active agents.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: March 31, 2020
    Assignees: Edixomed Limited, First Water Limited
    Inventors: Hugh Munro, Nicholas Boote
  • Patent number: 10568771
    Abstract: A wound dressing system that includes a conformal cover and an infusion pump is provided. The cover includes a fluid port and an oxygen catalyst. The infusion pump is configured to deliver a bioactive liquid to the cover via the fluid port. The liquid includes an oxygen precursor. Upon combination, the oxygen catalyst and precursor react to form oxygen. A method of applying a wound dressing system including a bioactive powder, a bioactive liquid, and a conformal cover to a wound site is also provided. The method includes applying the powder to the wound site; securing the cover around the wound site, where the cover includes an oxygen catalyst and a fluid port; and delivering the bioactive liquid to at least an inner layer of the cover via the fluid port, where the bioactive liquid includes an oxygen precursor.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: February 25, 2020
    Assignee: Avent, Inc.
    Inventors: John Gavin MacDonald, Ramanathan S. Lalgudi, Karien J. Rodriguez, Reade Harpham, Stephanie Kute, Alison Salyer Bagwell, Brian Joseph Cuevas
  • Patent number: 10570390
    Abstract: Compositions, devices, and methods for treating infections.
    Type: Grant
    Filed: August 20, 2012
    Date of Patent: February 25, 2020
    Inventors: Rodney J. Y. Ho, Brenda Newman
  • Patent number: 10548978
    Abstract: A microcapsule encapsulates a payload agent, the microcapsule having a microcapsule shell material that is rupturable (e.g., to release the encapsulated payload agent) via a retro-dimerization reaction.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: February 4, 2020
    Assignee: International Business Machines Corporation
    Inventors: Scott B. King, Brandon M. Kobilka, Joseph Kuczynski, Jason T. Wertz
  • Patent number: 10543476
    Abstract: Disclosed herein is a porous material comprising a biopolymer functionalized with a carbon dioxide capturing moiety; where the biopolymer is in the form of a foam or an aerogel having a bulk density of 500 grams per cubic meter to 2500 grams per cubic meter. Disclosed herein too is a method comprising functionalizing a biopolymer with a carbon dioxide capturing moiety; dissolving the biopolymer in an aqueous solution to form a first solution; reducing the temperature of the first solution to below the freezing point of the aqueous solution; displacing the aqueous solution with a first solvent that has a lower surface tension than a surface tension of the aqueous solution; and drying the first solvent to produce a porous biopolymer having a bulk density of 500 grams per cubic meter to 2500 grams per cubic meter.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: January 28, 2020
    Assignee: THE UNIVERSITY OF MASSACHUSETTS
    Inventors: Yinyong Li, Kenneth Raymond Carter, Kara Martin
  • Patent number: 10537659
    Abstract: A medical device comprising a structure formed of polyvinyl alcohol.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: January 21, 2020
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Jonathan Steven Alexander, Christen J. Boyer
  • Patent number: 10485891
    Abstract: Systems, methods, and apparatuses for forming a multi-function core for a dressing are described. The multi-function core includes a contact layer configured to be positioned adjacent to a tissue site, a wicking layer adjacent to the contact layer, an ion exchange layer adjacent to the wicking layer, an absorbing layer adjacent to the ion exchange layer, a blocking layer adjacent to the absorbing layer, and an odor-absorbing layer adjacent to the blocking layer. The contact layer, the wicking layer, the ion exchange layer, the absorbing layer, the blocking layer, and the odor-absorbing layer are coextensive and formed from a plurality of fibers disposed in a fibrous web. Methods of manufacturing the multi-function core are also described.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: November 26, 2019
    Assignee: KCI Licensing, Inc.
    Inventors: Brian Andrews, Timothy Mark Robinson, Christopher Brian Locke, David George Whyte
  • Patent number: 10470771
    Abstract: The present disclosure provides annular support structures for use in conjunction with stapling devices. These annular support structures may be suitable for reducing occurrences of leaking, bleeding and/or stricture, as well as anastomotic tension, when anastomosing various body structures.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: November 12, 2019
    Assignee: Covidien LP
    Inventors: William D'Agostino, Michael Bettuchi
  • Patent number: 10426670
    Abstract: The invention relates to a wound dressing which is particularly suited for therapeutically dressing wounds. Said wound dressing comprises at least one air permeable layer having a porous and/or foam-based structure, particularly in the form of a solid foam (“foam layer”), and at least one sorbent in the form of activated carbon.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: October 1, 2019
    Assignee: Blücher GmbH
    Inventors: Hasso von Blücher, Raik Schönfeld, Frank Pallaske
  • Patent number: 10350045
    Abstract: A repair material with multi-purpose for an abdominal wall hernia of the present invention relates to a technical field of medical consumables, which includes technical field of medical consumables. In the MPEG-PLLA copolymer, a molecular weight of MPEG is 2000-10000, and a molecular weight of PLLA is 3000-8000. Compared with PLCL, the repair material of the present invention is significantly improved in water absorption of the absorbable membrane to ameliorate healing effects, and a contact angle is greatly reduced. As a result, postoperative abdominal wall compliance is sufficient, which basically provides no discomfort. Therefore, compared with the PLCL, the present invention is more comfortable. In addition, the repair material of the present invention doesn't need to be heat-fitted, and polypropylene is completely fitted with the absorbable membrane, wherein no obvious boundary face is observed through a microscope, and separation never occurred.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: July 16, 2019
    Assignee: TransEasy Medical Tech.Co., Ltd
    Inventors: Jie Sun, Fan Chen, Hongying Qiao, Lingcui Ding, Kai Meng
  • Patent number: 10300182
    Abstract: A wound care device includes a flexible cover having a concave interior surface and a flange configured for sealing engagement with the skin of a patient so that the device can be affixed to the skin of the patient. An inlet tube is in fluid communication with the interior thereof and configured to deliver a fluid compound thereto. An outlet tube extends from the flexible cover and is in fluid communication with the interior thereof to allow aspiration of fluid from within the flexible cover. A programmable system delivers one or more of oxygen, saline, medicaments, UV light, and ultrasonic vibration on a schedule predetermined by a user of the device.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: May 28, 2019
    Inventor: Harjeet S Brar
  • Patent number: 10279072
    Abstract: Body tissue and structures in an airway may be treated with an artificial scab comprising an inhomogeneous, uncohesive, solid sheet-like body comprising a granular mixture of chitosan and polysaccharide particles. The artificial scab breaks apart into smaller pieces if peeled away from the surgical site or wound, thus reducing the risk of airway occlusion.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: May 7, 2019
    Assignee: Medtronic, Inc.
    Inventors: James B. Hissong, Matthew F. Myntti, Jennifer G. Medina
  • Patent number: 10265438
    Abstract: A biological construct for the repair and replacement of damaged connective tissue is provided. Methods of repairing or otherwise replacing connective tissue are also provided.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: April 23, 2019
    Assignee: BioDlogics, LLC
    Inventor: Timothy R. Brahm
  • Patent number: 10239856
    Abstract: Disclosed are macrocyclic compounds of formulae I, I?, II, II?, III, III?, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: March 26, 2019
    Assignee: UNIVERSITY DE STRASBOURG
    Inventors: Nicolas Winssinger, Sofia Barluenga, Martin Karplus
  • Patent number: 10213344
    Abstract: A medical dressing includes an adhesive, permeable layer, a fabric support, and a hydrochromatic layer. The adhesive, permeable layer is configured to adhere to skin near a wound, for example, an intravenous catheter or other percutaneous device insertion site. The fabric support is disposed on the adhesive, permeable layer. The hydrochromatic layer is disposed on the fabric support, and is configured to change a color appearance responsive to contact with moisture.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: February 26, 2019
    Assignee: Availtek LLC
    Inventors: Terri L. Bogue, Robert L. Bogue
  • Patent number: 10195556
    Abstract: A laminated nonwoven fabric includes a first nonwoven fabric containing first fibers, a second nonwoven fabric containing second fibers, a third nonwoven fabric containing third fibers, and an adhesive. The second nonwoven fabric is laminated on the first nonwoven fabric, and the third nonwoven fabric is laminated on the second nonwoven fabric on an opposite side with respect to the first nonwoven fabric. The adhesive is disposed between the first nonwoven fabric and the third nonwoven fabric. An average fiber diameter of the second fibers is equal to or less than 3 ?m, and is smaller than an average fiber diameter of the first fibers. The third nonwoven fabric has a protrusion including a part of the third fibers entangled with each other on a surface facing the second nonwoven fabric. At least a part of the adhesive is disposed between the protrusion and the first nonwoven fabric.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: February 5, 2019
    Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.
    Inventors: Koji Motomura, Takahiko Murata, Hiroto Sumida, Takatoshi Mitsushima, Keiji Fujiwara
  • Patent number: 10131794
    Abstract: The present invention provides for a household, agricultural, coating or personal care product composition containing the crosslinked reaction product of a network composition the reaction product of: (i) at least one anionic polymerizable ethylenically unsaturated monomer (I) selected from the group consisting of [CH2?C(R3)C(O)OXa(C2H4O)b(C3H6O)c(C4H8O)d]pP(O)(OY)q(OZ)r and CH2?C(R3)C(O)OXa?(C2H4O)b?(C3H6O)c?(C4H8O)d?—SO3—Y) where R3=H or alkyl of 1 to about 6 carbon atoms; X=alkyl, aryl, or alkaryl diradical connecting group of 0 to about 9 carbon atoms; a, a?, b, b?, c, c?, d and d? are 0 to about 100; q is 0 to about 2; r is 0 to about 2; p is 1 to about 3 subject to the limitation that p+q+r=3; and Y and Z is H, or metal ion; and (ii) one or more additional monomers (II) selected from the group consisting of acrylic acid/acrylate, methacrylic acid/methacrylate, acrylamides, vinyl acetate and styrene, which are copolymerizable with (I); and (iii) a cross-linking agent (III), capable of copolymerizin
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: November 20, 2018
    Assignee: Momentive Performance Materials Inc.
    Inventors: Ning Lu, Sigfredo Gonzalez, Ernie Silvestre, Geng Wang
  • Patent number: 10124064
    Abstract: Pharmaceutical compositions comprising an aminoglycosidic antibiotic and at least one zinc-chelating agent in a specified concentration, and methods of inhibiting bacterial colonization, biofilm formation and if treating bacterial infections utilizing the compositions are provided. Topical formulations suitable for wound care, and surface-applicable formulations suitable for medical, industrial and household disinfecting needs are also described.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: November 13, 2018
    Assignee: University of Cincinnati
    Inventors: Andrew B. Herr, Gary Young
  • Patent number: 10080816
    Abstract: This invention relates to a wound dressing, particularly to a stimuli responsive wound dressing comprising a lyophilized hyaluronic acid (HA) hydrogel, and a plurality of devices embedded within said lyophilized hyaluronic acid hydrogel. Each of the plurality of devices including chitosan and hypromellose and may be formed as biofilms and/or electrospun fiber mats.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: September 25, 2018
    Assignee: University of the Witwatersrand, Johannesburg
    Inventors: Viness Pillay, Yahya Essop Choonara, Pradeep Kumar, Lisa Claire Du Toit, Naeema Mayet
  • Patent number: 10080823
    Abstract: The present disclosure relates to substrates associated with nitric oxide.
    Type: Grant
    Filed: November 17, 2010
    Date of Patent: September 25, 2018
    Assignee: Gearbox LLC
    Inventors: Roderick A. Hyde, Muriel Y. Ishikawa, Leif T. Stordal, Lowell L. Wood, Jr.
  • Patent number: 10076586
    Abstract: A solid wound dressing material comprising: at least about 5 wt % collagen; from about 6 wt % to about 9 wt % polyvinylpyrrolidone triiodide (PVP-I); and from 0 wt % to about 20 wt % water; wherein the weight percentages are based on the dry weight of the composition. Also provided are methods of making such materials, and wound dressings comprising such materials. In another aspect the invention provides a solid wound dressing material comprising: at least about 5 wt % collagen; from about 10 wt % to about 90 wt % Cadexomer iodine; and from 0 wt % to about 20 wt % water, wherein the weight percentages are based on the dry weight of the composition. Also provided are wound dressings comprising the materials.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: September 18, 2018
    Assignee: KCI USA, INC.
    Inventor: Lorna McInroy
  • Patent number: 9994488
    Abstract: An ultrafine continuous fibrous ceramic filter, which comprises a filtering layer of a fibrous porous body, wherein the fibrous porous body comprises continuous ultrafine fibers of metal oxide which are randomly arranged and layered, and powdery nano-alumina incorporated into the ultrafine fibers or coated thereon, the ultrafine fibers being obtained by electrospinning a spinning solution comprising a metal oxide precursor sol-gel solution, and optionally, a polymer resin, and sintering the electrospun fibers, in which the ultrafine fibers have an average diameter of 10˜500 nm, and the fibrous porous body has a pore size of maximum frequency ranging from 0.05 to 2 ?m, exhibits high filtration efficiency at a high flow rate, and can be regenerated.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: June 12, 2018
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Seong Mu Jo, Dong Young Kim, Sung-Yeon Jang, Jeong Joo Choo
  • Patent number: 9956245
    Abstract: The present invention relates to a gel composition comprising a glucan and a gelling agent, said composition having a melting point (gel to sol) above 37° C., as well as to the uses of this composition in therapy, in particular in wound healing.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: May 1, 2018
    Assignee: BIOTECH PHARMACON ASA
    Inventors: Rolf Engstad, Dag-Eirik Ramsøy, Erik Steene
  • Patent number: 9925210
    Abstract: The present invention comprises chitosan materials and methods of using carbonic acid for aqueous solubilization of neutralized or pre-treated chitosan gels and provides, among other things, substantially acid salt free composition native final forms without requiring subsequent acid salt elution. The invention includes chitosan-based solid and semi-solid material forms, optionally reinforced with chitosan fibers, such as powders, fibers, films, matrices, sponges, implants, scaffolds, fillers, and hydrogels. Native final forms are produced from chitosan powder solubilized in an aqueous acidic solution, processed to form a high pH hydrated chitosan gel precipitate material that is then neutralized by water washing and re-solubilized substantially to chitosan solution using carbonic acid.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: March 27, 2018
    Assignee: Tricol Biomedical, Inc.
    Inventors: Simon McCarthy, Barbara McGrath, Sam Kuhn, Jess Kimball, Michael Stolten, Amanda Bennett
  • Patent number: 9867900
    Abstract: The present invention relates to a fibrous haemostat composition that is able to safely gradually and fully degrade in a human or animal body within about 30 days and so can be utilized by physicians to stem a flow of blood and promote healing both after as well as during surgical procedures.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: January 16, 2018
    Assignee: Medtrade Products Limited
    Inventors: Craig Hardy, Andrew Hoggarth, June Gladman
  • Patent number: 9855313
    Abstract: Provided herein are compositions and methods for use in promoting wound healing and tissue regeneration following tissue injury in a subject.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: January 2, 2018
    Assignee: MUSC Foundation for Research Development
    Inventors: Gautam Ghatnekar, Robert Gourdie, Jane Jourdan
  • Patent number: 9821084
    Abstract: Compositions comprising clay minerals and methods for their use in promoting hemostasis are provided. The compositions comprise clay minerals such as bentonite, and facilitate blood clotting when applied to a hemorrhaging wound. Electrospun or electrosprayed materials (e.g. bandages, micron beads, etc.) which include clay minerals, and methods for the treatment of acute hemorrhage, are also provided.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: November 21, 2017
    Assignee: Virginia Commonwealth University
    Inventors: Robert F. Diegelmann, Kevin R. Ward, Marcus E. Carr, Gary Lee Bowlin
  • Patent number: 9821063
    Abstract: Pharmaceutical compositions comprising an aminoglycosidic antibiotic and at least one zinc-chelating agent in a specified concentration, and methods of inhibiting bacterial colonization, biofilm formation and if treating bacterial infections utilizing the compositions are provided. Topical formulations suitable for wound care, and surface-applicable formulations suitable for medical, industrial and household disinfecting needs are also described.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: November 21, 2017
    Assignee: University of Cincinnati
    Inventors: Andrew B. Herr, Gary Young
  • Patent number: 9808553
    Abstract: Haemostatic wound dressings are described. The dressings comprise a non-colloidal porous dressing material, and a plurality of fibrinogen-binding peptides immobilised to the non-colloidal porous dressing material, wherein each fibrinogen-binding peptide comprises: an amino acid sequence Gly-Pro-Arg-Xaa (SEQ ID NO: 1) at an amino-terminal end of the peptide, wherein Xaa is any amino acid other than Val, preferably Pro, Sar, or Leu; or an amino acid sequence Gly-His-Arg-Xaa (SEQ ID NO: 2) at an amino-terminal end of the peptide, wherein Xaa is any amino acid other than Pro. The dressings are able to accelerate haemostasis without requiring enzymatic activity. In particular, the dressings to do not rely on the action of exogenous thrombin, and can be stored long-term at room temperature in solution. Methods of making the dressings, and use of the dressings to control bleeding are also described.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: November 7, 2017
    Assignee: HAEMOSTATIX LIMITED
    Inventors: Greg Walker, Sarah Margaret Middleton
  • Patent number: 9795706
    Abstract: Disclosed is 1) a method for greatly increasing the solubility of useful actives in siloxane matrix-forming preparations, and 2) the associated preparations, themselves. Volatilizing coagents are utilized to give novel gels containing heretofore siloxane-insoluble additives.
    Type: Grant
    Filed: April 4, 2016
    Date of Patent: October 24, 2017
    Assignee: Advanced Bio-Technologies, Inc.
    Inventor: Paul Guilbaud
  • Patent number: 9782381
    Abstract: Molecular target for healing or treating wounds and, in particular chronic, human wounds, are described. The molecular target is PTPRK, or a protein 50% homologous therewith, and which retains the same activity as PTPRK protein. Further, methods and novel therapeutics are described for treating said wounds.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: October 10, 2017
    Assignee: University College Cardiff Consultants Limited
    Inventors: Wenguo Jiang, Keith Harding
  • Patent number: 9771904
    Abstract: Provided are a self-cleaning air filtering material and a preparation method therefor. The air filtering material comprises: a submicron fiber layer (2) at an inflow surface for surface filtration, a supporting area (3) for supporting and a mixed area (5) between the submicron fiber layer (2) and the supporting area (3), wherein the mixed area (5) is formed by contacting and mixing part of the fibers in the submicron fiber layer (2) and the supporting area (3) with each other during the one-step formation of the submicron fiber layer (2) and the supporting area (3) by passing through a double-layer headbox.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: September 26, 2017
    Assignee: Fibrway Materials Science & Technology Development Co., Ltd.
    Inventors: Jian Hu, Yun Liang, Yi Wang, Jingshan Zeng
  • Patent number: 9744262
    Abstract: The invention provides engineered biomaterials derived from plant products. The engineered biomaterials are useful for biomedical applications. The engineered biomaterials are able to support the growth of animal calls.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: August 29, 2017
    Assignee: DREXEL UNIVERSITY
    Inventors: Peter I. Lelkes, Dara L. Woerdeman, Leko Lin, Anat Katsir
  • Patent number: 9730956
    Abstract: The present invention relates to a liquid nitric oxide releasing solution (NORS) comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of nitric oxide gas (gNO). The present invention also relates to a liquid NORS comprised of at least one nitrite compound having a concentration of no greater than about 0.5% w/v and at least one acidifying agent, wherein the NORS releases a therapeutically effective amount of gNO. The present invention also relates to a method for the treatment of a wound in a human, the method comprising administering to the human a liquid NORS comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of gNO.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: August 15, 2017
    Assignee: Nitric Solutions, Inc.
    Inventors: Alex Stenzler, Christopher C. Miller, Gilly Regev-Shoshani
  • Patent number: 9725574
    Abstract: The present disclosure provides a polyester-based plasticizer for resin, which is represented by Formula 1.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: August 8, 2017
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Young Lyeol Yang, Ji Ho Hwang, Do Yong Shim
  • Patent number: 9662374
    Abstract: The invention relates to a hemostatic composition in powder form comprising collagen of the fibrillar type comprising a content of fibrous collagen and/or fibrillar collagen of at least 70% by weight relative to the total weight of the collagen, and at least one monosaccharide, and optionally, at least one compound selected from coagulation factors and glycosaminoglycans. The invention further relates to a method for preparing such composition, and to a unit comprising such composition and a spraying device.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: May 30, 2017
    Assignee: BIOM'UP
    Inventors: Christian Gagnieu, Patricia Forest, Sylvain Picot
  • Patent number: 9655967
    Abstract: The formation of scars at a wound site is reduced by contacting the wound site with an effective dose of an inhibitor of focal adhesion kinase (FAK) activity or expression. Blockade of FAK is sufficient to prevent mechanical and inflammatory stimuli from activating MCP-1 pathways. In addition to these chemokine-mediated mechanisms, inhibition of FAK may control fibrosis by blocking fibroblast collagen production. Pharmacologic blockade of FAK significantly reduces scar formation in vivo.
    Type: Grant
    Filed: December 5, 2012
    Date of Patent: May 23, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Geoffrey C. Gurtner, Michael T. Longaker, Victor W. Wong
  • Patent number: 9572907
    Abstract: The present disclosure relates to implantable medical devices containing a polymeric film layer containing glycerol and at least one biopolymer.
    Type: Grant
    Filed: October 1, 2010
    Date of Patent: February 21, 2017
    Assignee: Covidien LP
    Inventors: Joshua Stopek, Amin Elachchabi
  • Patent number: 9555157
    Abstract: A method of inducing hemostasis in a wound. A hemostatic product is applied to a wound. The hemostatic product includes at least one hemostasis component. The hemostatic product is retained with respect to the wound by positioning a hydrogel material at least partially over the hemostatic product. At least a portion of the hemostatic product is dissolved. Hemostasis is induced in the wound with the at least one hemostasis component. The hydrogel material is separated from the wound. Substantially all of the hemostatic product remains on the wound.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: January 31, 2017
    Assignee: St. Teresa Medical, Inc.
    Inventors: Curtis Olson, Tim Floyd, Phil Messina
  • Patent number: 9433682
    Abstract: Provided herein is a hydrogel composition comprising a graphene, a chitosan, and a polyethylene (glycol) diacrylate (PEGDA) (PCG hydrogel). In some embodiments, the hydrogel further comprises a N-isopropylacrylamide (NIPAM) (TPCG hydrogel). Also provided is a method for differentiating a mesenchymal stem cell comprising contacting the cell with the PCG hydrogel. Further provided herein is a method for delivering a pharmaceutical composition to a cell comprising administering to the cell a TPCG hydrogel and the pharmaceutical composition.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: September 6, 2016
    Assignees: University South Florida, National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS)
    Inventors: Subhra Mohapatra, Chunyan Wang
  • Patent number: 9433664
    Abstract: The present invention relates to normalizing impaired haemostasis comprising administering a clotting factor treatment selected from the group consisting of (1) FII; (2) PCC; and (3) a three factor combination of FH, FX and FVIIa. The clotting factor treatment can be administered in combination with fibrinogen. The clotting factor(s) can be recombinant human clotting factor(s).
    Type: Grant
    Filed: September 19, 2011
    Date of Patent: September 6, 2016
    Assignee: MEDIMMUNE LIMITED
    Inventors: Ann Lovgren, Kenny Hansson
  • Patent number: 9399068
    Abstract: A viscoelastic hydrogel based on a protein hetero-assembled with a polymer is provided. The protein cannot self-assemble with itself and the polymer cannot self-assemble with itself. The protein has a first association sequence (1stA) and a first spacer (1stSp). The polymer has a second association sequence (2ndA) and a second spacer (2ndSp). The first association sequence and the second association sequence are physically cross-linked to interact with each other with a 1:1 known and specific stoichiometry to form a three dimensional scaffold. The protein is represented by {1stA(1stSp)}x1stA, where x is ?2, and the polymer is represented by {2ndA(2ndSp)}y2ndA, where y?2.
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: July 26, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Sarah C. Heilshorn, Widya Mulyasasmita, Lei Cai
  • Patent number: 9393341
    Abstract: A stiffening layer for facilitating application of a plastic film to skin, the plastic film being a component in a wound dressing or other medical device and having the stiffening layer removably attached to one side thereof, at least a part of the other side of the film being provided with a layer of self-adhering adhesive. The stiffening layer is made of a stretchable material having a thickness of between 0.5-10 mm. The stiffening layer covers the whole area of the film and is divided into two or more portions by cutting line or lines.
    Type: Grant
    Filed: February 6, 2009
    Date of Patent: July 19, 2016
    Assignee: Mölnlycke Health Care AB
    Inventors: Tomas Fabo, Anna Svensby
  • Patent number: 9393347
    Abstract: A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold comprised of collagen and a secondary scaffold comprising a soluble collagen solution in combination with a surfactant generated and positioned within the primary scaffold. A process for preparation of the double-structured implant or the stand alone secondary scaffold comprising lyophilization and dehydrothermal treatment.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: July 19, 2016
    Assignee: Histogenics Corporation
    Inventors: Hans P. i. Claesson, Laurence J. B. Tarrant, R. Lane Smith, Sonya Shortkroff
  • Patent number: 9387227
    Abstract: A composition for the topical treatment of sores, lesions, ulcers, and other disorders of the skin, said composition includes a combination of a bee product and caffeine. The bee product may comprise bee pollen, bee propolis, honey, or royal jelly. Variations of the composition may also contain a tannin. The composition may be in the form of an ointment or cream that is applied topically to an affected area of the body. The composition may also be used in other forms, such as a spray, shampoo, soap, lipstick, or adhesive bandage. The invention may also be useful as a health beverage.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: July 12, 2016
    Inventor: Gilbert Clinton Gee
  • Patent number: 9345803
    Abstract: An absorbent product intended particularly for use as a wound dressing comprises an admixture of carboxymethyl chitosan and chitosan wherein the chitosan incorporates at least one antimicrobial agent. Absorbency is provided by the carboxymethyl chitosan and antimicrobial properties by the antimicrobial agent incorporated in the chitosan.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: May 24, 2016
    Assignee: ADVANCED MEDICAL SOLUTIONS LIMITED
    Inventor: Colin Bradford