Abstract: A dressing for promoting healing and pain relief of the body of a living organism having a pathologic condition has at least one layer of conductive material having a resistance no greater than 1000 ?/cm2. When placed proximate a portion of the body of the living organism suffering from the pathologic condition, the dressing alters the electrodynamic processes occurring in conjunction with said pathologic condition to promote healing and pain relief in the living organism. When used as a wound dressing, the conductive material is placed in contact with tissue around the periphery of the wound and with the wound, lowering the electrical potential and resistance of the wound and increasing the wound current.

Abstract: A thin aqueous cataplasm prepared by laminating an adhesive layer (base) having specified constituents on a support which consists of a fiber film prepared by heat-fusing a soft plastic resin on a composite fiber prepared by entangling a natural fiber and a soft plastic fiber, or consists of a fiber film prepared by heat-fusing a plastic resin having a soft part and a hard part in common on a fiber consisting of a plastic having a soft part and hard part in common. The thin aqueous cataplasm retains a moisture-protecting effect on the skin and provides comfortable feeling in its use.

Abstract: The present disclosure relates to nitric oxide sensors and systems.

Abstract: A bandage and method for vital bleaching of human skin discolored as a result of bruising (ecchymosis) provides transdermal delivery of hydrogen peroxide as a bleaching agent in gel or other form. The bandages provide delivery and application by waterproof and light-proof strips and pads carrying hydrogen peroxide in sufficient concentration for safe oxidation of bruised tissue with resultant eradication of visible discoloration, and amelioration of associated tenderness.

Abstract: The present invention relates to a composition containing at least one nutritive, at least one disinfecting or decontaminating and/or at least one protease-inhibiting active compound and/or active compound complex for the external care and/or treatment of wounds of the human or animal body.

Abstract: A wound care dressing comprising one or more nonwoven blankets, where each nonwoven blanket comprises a plurality of fibers, where each of the plurality of fibers are formed from one or more saccharides in optional combination with one or more medicaments.

Abstract: The present invention relates to a composition and wound dressing for delivering a composition comprising povidone-iodine and sucrose mixture. The composition is gelled and, in one embodiment, is impregnated on a gauze or other like material for application to an exuding or non-exuding wound.

Abstract: A bandage and method for vital bleaching of human skin discolored as a result of bruising (ecchymosis) provides transdermal delivery of hydrogen peroxide as a bleaching agent in gel or other form. The bandages provide delivery and application by waterproof and light-proof strips and pads carrying hydrogen peroxide in sufficient concentration for safe oxidation of bruised tissue with resultant eradication of visible discoloration, and amelioration of associated tenderness.

Abstract: A method for treating a wound, and a dressing for wound care management comprising a three-dimensional body of glass-based fibers comprising one or more glass-formers selected from the group consisting of P2O5, SiO2, and B2O3; at least about 25 wt % of the fibers have a diameter between about 200 nm and about 4000 nm, and a length:width aspect ratio of at least about 10. In another form, the glasses are in the form of particles in an ointment or cream applied to a wound. In yet other forms the glasses are employed as fibers formed into sutures for closing a wound, or as particles in a surgical glue for closing a wound.

Abstract: A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.

Abstract: Disclosed are optimized keratin preparations for use in medical applications. Methods to produce optimized keratin preparations are provided for use in biomedical applications, particularly for the treatment of bleeding, and for the treatment of wounds. Also disclosed are surgical or paramedic aids comprising a substrate with keratin preparations provided thereon, and kits comprising keratin derivatives packaged in sterile form.

Abstract: The present invention provides a multilayer bandage, having a webbing for contacting a wound and a first membrane that has at least one water-insoluble polymer and is water-impervious. The present invention further provides methods for making the multilayer bandage, methods of using the multilayer bandage for accelerated wound healing, and kits having compositions of the present invention.

Abstract: Assemblies for the adhesive attachment to the skin or mucosa of a host are disclosed. The assembly or transdermal patch includes an outer backing layer, a first layer of adhesive on the inner surface of the outer backing layer, an inner backing layer, and an intermediate release liner between the first layer of adhesive and the inner backing layer. The intermediate release liner includes a releasable surface on both its inner and outer surfaces.

Abstract: Transition metal (e.g., silver and copper) derivatized phosphorylated polysaccharides (cellulose, starch, gauze) provide antimicrobial and elastase sequestration properties to wound dressings, and the wound dressing have enhanced water sorption and elastase sequestration when used with alginates. Wound dressings with alginates (e.g., silver alginate, crosslinked alginates, etc.) provide enhanced wound fluid absorption as well as elastase sequestration.

Abstract: Processes for preparing polyurethane hydrogels which include free-radically cross-linking: A) hydrophilic polyurethanes having one or more olefinically unsaturated groups selected from the group consisting of acrylate and methacrylate groups; in the presence of B) water; and C) a redox system including a water-soluble oxidizing agent and a water-soluble reducing agent, the oxidizing agent being capable in terms of redox potential of reacting with the water-soluble reducing agent by free-radical formation, wherein the hydrophilic polyurethanes are based on hydroxyl-functional polyalkylene oxides.

Abstract: The present invention relates to a multilayered wound dressing particularly for wound treatment in the granulation and epithelization phase. The wound dressing comprises a) a first layer having a first side and a second side and comprising a water-containing hydrogel matrix, and b) at least one second layer having a first side and a second side and comprising a hydrophilic polymer foam, wherein the polymer foam comprises a water fraction of at least 10% by weight of water.

Abstract: Compositions are provided that contain a TRPV1 agonist, such as capsaicin, and a solvent system. Topical application of the composition results in rapid delivery of agonist to the dermis and epidermis. Method of using the compositions for reducing nociceptive nerve fiber function in subjects, and for treatment of capsaicin-responsive conditions are also provided.

Abstract: There is provided an anti-microbial composition comprising a cationic peptide and a glycineglycine endopeptidase. The composition has been found to be synergistic against bacteria, especially Gram positive bacteria such as Staphylococcus aureus MSSA or MRSA. In one embodiment the composition comprises ranalexin, dermaseptin, magainin or mixtures thereof together with lysostaphin. The composition is useful for treating surfaces, including a wound surface in a patient or surfaces of an object (e.g. surgical instrument) or room.

Abstract: Wound dressing assemblies and methods of producing the wound dressing assemblies. The wound dressing assemblies various comprise individual layers of nanomaterials that have been formed according to an electrospinning process. Each of the layers can have different characteristics and qualities. The invention also provides guidance in selecting materials to form a wound dressing assembly, as well as possible adaptations to the electrospinning process to provide different characteristics for particular materials.

Abstract: Apparatus suitable for use in the prevention and treatment of burn induced compartment syndrome facilitates the rapid and efficient deployment of enzymatic compositions to the affected limb or limbs of a burn victim suffering from a circumferential burn. The apparatus includes a flexible, water-impermeable generally cylindrical covering layer. The covering layer has an inner surface facing the limb and an outer surface. The covering layer has a proximal sealable open end through which the burned limb is inserted and a distal closed end. An enzymatic escharotomy agent is contained within the covering layer. The covering layer retains the enzymatic escharotomy agent in close proximity to the burned limb, and the apparatus is enclosed within a sterile sealed package evacuated from moisture.

Abstract: Composite structures composed of a device as a core structure, being a medical device or article, and a porous polymeric coat and designed capable of encapsulating bioactive agents while retaining the activity of these agents are disclosed. Further disclosed are processes of preparing such composite structures.

Abstract: The present invention provides a method of treating a leg ulcer comprising contacting the leg ulcer with a collagen biofabric. The leg ulcer may be a venous, arterial, diabetic or decubitus (pressure) ulcer. The invention further provides kits comprising one or more pieces of collagen biofabric for the treatment of a leg ulcer.

Abstract: A silicone hydrogel formulation may contains random and/or block copolymers or oligomers or macromers. The silicone copolymer is copolymerized or blended with other polymers or monomers or macromers to obtain final formulation. The silicone hydrogel may contain crosslinking groups to provide a complete or partially crosslinked final structure. The silicone hydrogel formulation may be pre-formed as a film or other structure, or it may be polymerized during application as in the case of an adhesive formulation. A wound dressing comprising a silicone hydrogel formed as a film, either prior to application to a wound or in situ on a wound, which film has gas permeability, moisture permeability, and high water content, wherein said silicone hydrogel is formed from a polymerizable silicone such as a difunctional polydimethylsiloxane methacrylate and crosslinking agents such as N,N-dimethyllacrylamide (DMA), 2-hydroxyethyl methacrylate (HEMA), and trimethylsiloxy silane (TRIS).

Abstract: A wound care dressing is disclosed. The wound care dressing comprises one or more nonwoven blankets, where each nonwoven blanket comprises a plurality of fibers, where each of the plurality of fibers are formed from one or more saccharides in optional combination with one or more medicaments. The invention further comprises a method to treat wounds using the wound care dressing as a transcutaneous pulsatile drug delivery system that may be used externally (e.g. skin, bones, cartilage, and organs) or internally (e.g. internal surface of a blood vessel).

Abstract: Compositions containing biologically active peptides are disclosed. Active peptides are isolated fragments derived from human hair or sheep wool keratin proteins. Compositions may be prepared for pharmaceutical or topical administration or for use in cosmetic preparations.

Abstract: The present invention is directed to a hemostatic composite structure having a bioabsorbable fabric or non-woven substrate having at least two major oppositely facing surface areas and a continuous non-porous polymer-based film that is laminated on one major surface of said substrate. The bioabsorbable fabric substrate can be an oxidized polysaccharide and/or the non-woven substrate can be made from bioabsorbable, non-cellulosic derived polymers. The continuous non-porous polymer based film can be a bioabsorbable polymer. The present invention also relates to a method for providing hemostasis by applying a composite structure described herein onto a wound site in need of a hemostatic device wherein a major surface of the substrate without the film layer is applied onto the wound site.

Abstract: A wound care bandage for treating a wound is provided. The bandage includes an SIS layer to be placed on the wound surface and a cover to placed over the wound. Illustratively, the bandage further includes a structure to provide a vacuum space. A method for promoting wound healing is further provided. The method includes applying the above-mentioned wound care bandage to the wound and creating a vacuum in the vacuum space to draw blood controllably from the wound into the SIS layer.

Abstract: A method of treating a wound using a customized dressing. In the method, at least one wound characteristic is evaluated. A treatment need as a function of the at least one wound characteristic is determined. A dressing having a dressing characteristic responsive to the treatment need is fabricated and applied to the wound. A dressing for use therewith and an apparatus and system for fabricating the dressing are provided.

Abstract: Novel phosphate starch derivatives are useful in wound healing. Novel phosphorylated cottons are useful in wound healing. Silver-derivatized wound care products are provided which survive washing and remain part of the wound care product. Silver-derivatized wound care products are provided that have favorable elastase-sequestering activity while advantageously appearing white-colored, without needing to darken to grey or black as usually would occur when working with silver. Also, starch products with outstanding water uptake are provided.

Abstract: De-differentiation protocols are described herein for generating progenitor cells from adult connective tissue, in particular adult human fibroblasts. The de-differentiation protocols described herein comprise culturing the differentiated cells with an amount of FGF2 to de-differentiate the cells. These de-differentiated cells may then be cultured and used for experimentation, amplification and clinical applications. The clinical applications include the use of the cells for tissue and cell based therapies.

Abstract: The invention is directed to preparation of stem cell and physiologically acceptable matrix compositions. Compared with previous tissue engineering materials, the stem cell-matrix compositions of the present invention do not require long-term incubation or cultivation in vitro prior to use in vivo applications. The stem cells can be from numerous sources and may be homogeneous, heterogeneous, autologous, and/or allogeneic in the matrix material. The stem cell-matrix compositions provide point of service utility for the practitioner, wherein the stem cells and matrix can be combined not long before use, thereby alleviating costly and lengthy manufacturing procedures. In addition, the stem cells offer unique structural properties to the matrix composition which improves outcome and healing after use. Use of stem cells obtained from muscle affords contractility to the matrix composition.

Abstract: The present invention relates to a haemostatic material comprising a carrier layer and a material for wound contact comprising at least one haemostat in particulate, granular, powder, flake or short fibrous form. Such a haemostatic material is useful, for example, in reducing or stopping bleeding of a physiological target site in a person or animal, and can also be used to stem bleeding during medical procedures.

Abstract: An antimicrobial medical dressing provides a combination of antimicrobial agents in various concentrations that protect against microorganisms, absorb exudates, and promote healing. The antimicrobial agents may include compositions of ethanol, hydrogen peroxide, and/or ethylenediaminetetraacetic acid.

Abstract: In one embodiment, a method of making a wound dressing comprises dissolving at least one hemostatic agent in at least one solvent to form a solution. The method continues by freeze drying the solution to form a sponge. The method further comprises including an enzyme in the sponge that enables a human body to readily degrade the hemostatic agent.

Abstract: The present invention provides a hydrogel composition, preferably for the treatment of wounds, comprising a hydrophilic co-polymer carrying multiple pendant anionic groups, wherein the polymer is derived from a first monomer and a second monomer, wherein both monomers have an octanohwater partition coefficient Log P value of less than 0, and, the Log P value of the first monomer is greater (more positive) than the second monomer. Preferably the difference between the Log P value for the two monomers is at least 0.1, preferably at least 0.2. The difference between the Log P value for the two monomers is preferably less than 2. The weight ratio (w/w) of the first monomer/second monomer in the hydrogel composition is preferably equal to or more than about 1. The pendant anionic groups may be sulphonyl groups, e.g. sulphonic acid groups or salts thereof. The anionic group in both first and second monomers may be in salt form and the counterion for both monomers is preferably the same.

Abstract: Methods and compositions comprising an anti-ostepontin agent and/or a PDGF receptor blocker or antagonist, alone or in combination with one or more anti-connexin agents, for example, one or more anti-connexin polynucleotides and/or one or more anti-connexin peptides or peptidomimetics, are provided for the promotion and/or improvement of wound healing and/or tissue repair, and for anti-scarring, anti-inflammatory, anti-fibrosis and anti-adhesion indications.

Abstract: The present invention provides methods and compositions for sequentially and separately reducing infection and/or inflammation and regenerating tissue at a lesion site, by contacting the lesion site with a biodegradable scaffold that first delivers one or more agents at the lesion site to reduce infection and/or inflammation and then delivers one or more agents to regenerate tissue at the lesion site after inflammation is reduced.

Abstract: Apparatus and process to create, expand, and localize the population of stem cells in adult tissues by placing a foreign body either in omentum or in the subcutaneous tissue. The apparatus 1) traps the granulation fluid, cells a fluid rich in a myriad of growth factors, 2) mobilizes and concentrates free-floating stem cells in the granulation fluid, and 3) stimulates the growth of a new tissue around the apparatus, which provides another source of stem cells. Stem cells obtained by this process can be used as freshly isolated or after culturing, which can be used for wound healing, treating diseases, and regenerating organs in animals and humans. The granulation fluid could substitute the stem cells in many of their applications and offers the convenience of an injectable medicine for treating animal and human diseases.

Abstract: A compressive dressing and method allow quick, simple and effective treatment of head trauma by cinching and, optionally, an elastomeric layer.

Abstract: An adhesive device used as a wound dressing, ingredient delivery device or IV hold-down in which inadvertent edge release of these devices along the periphery of the polymeric film layer is minimized when the handling layer, which is adhered to the polymeric film layer, is removed after application of the polymeric film layer to the patient.

Abstract: In one embodiment, an article incorporating a selectively-releasable adhesive includes a substrate having a surface and a layer of selectively-releasable adhesive provided on the surface of the substrate, the selectively-releasable adhesive comprising a copolymer formed from a multifunctional alcohol and a multifunctional carboxylic acid that has been cured.

Abstract: In one embodiment, a method for preparing a selectively releasable adhesive includes condensing a multifunctional alcohol and a multifunctional carboxylic acid to form a prepolymer and curing the prepolymer at an elevated temperature and a vacuum to produce a cured polymer.

Abstract: Robust polymeric hydrogels and a method to fabricate antimicrobial non-woven fibrous wound dressing with controlled silver release that may be used for anti-infective medical implants and anti-infective coating for implantable medical device. The hydrogels may be provided in non-woven fibrous wound dressing and anti-infective implantable medical devices, especially for reconstructive oral and bone surgery.

Abstract: A therapeutic device for promoting the healing of a wound in a mammal is disclosed. An exemplary device comprises a permeable structure having a plurality of depressions formed in a surface thereof. In use, the surface having the depressions is disposed adjacent a surface of the wound. A method of treating a wound comprises the steps of providing a permeable structure comprising a plurality of randomly disposed fibers and having i) a plurality of wound surface contact elements disposed between end portions of the structure, and ii) a plurality of voids defined by the contact elements; and applying the permeable structure to at least one surface of the wound.

Abstract: Disclosed herein is a wound dressing. The wound dressing includes a first fiber layer and a second fiber layer stacked on and bound to the first fiber layer. The first fiber layer consists of a plurality of a first fiber that are made of an alginate wherein the first fibers are respectively bound with one another, and are substantially extended in parallel along a first direction. The second fiber layer consists of a plurality of a second fiber that are made of an alginate, wherein the second fibers are respectively bound with one another, and extend in parallel along a second direction that is not parallel to the first direction. The second layer is stacked on the first layer with the second fibers being bound with the first fibers. The first fibers and the second fibers respectively have a length such that the wound dressing has a breaking strength for at least 1.5 kg.

Abstract: A composition for burn treatment containing, in % by weight: Almond oil (sweet): ?9-10 Almond oil (bitter): 7-8 Lavender oil: 4-5 Beeswax: 8-9 Bee Pollen: 3-4 Purified honey: 50-60 Propolis: 0.2-1?? Water: ??8-12.

Abstract: Superabsorbent polymer particles with improved surface cross-linking and their use in absorbent articles. The superabsorbent polymer particles comprise polymer chain segments, wherein at least a part of the polymer chain segments are covalently cross-linked to each other and wherein at least a part of the cross-links include the reaction product of cross-linking molecules having at least two C?C double bonds and further include the reaction product of radical former molecules. These cross-links are present at surfaces of the superabsorbent polymer particles.

Abstract: A product for absorption purposes comprises a water insoluble support matrix substituted with a hydrophobic entity and a positively charged entity. The hydrophobic entity comprises di-alkyl carbamoyl chloride (DACC) and the positively charged entity comprises polyethyleneimine (PEI). The product is capable of removing microorganisms, including viruses, from air and liquid. Methods for manufacturing the product and uses and applications of the product are also presented.

Abstract: A biodegradable microfiber absorbent comprises a substantially homogeneous mixture of at least one hydrophilic polymer and at least one biodegradable polymer. The absorbent can be prepared by an electro hydrodynamic spinning of a substantially homogeneous polymer mixture. Medical dressings for burns and wounds, cavity dressings, drug delivery patches, face masks, implants, drug carriers that comprises at least one microfiber electrospun from a polymer mixture are provided. The dressings can have variable water vapor penetration characteristics and variable biodegradation times.

Abstract: A chitinosanase obtainable from the fungus Alternaria alternate. The chitinosanase specifically cleaves a GlcNAc-GlcN glycosidic bond in a chitosan, possesses a relative molecular weight as determined by SDS-PAGE of about 18 kDa, has an optimum pH of about 4 and has an optimum temperature of about 70° C.