Transdermal Or Percutaneous Patents (Class 424/449)
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Patent number: 8034374Abstract: An adhesive patch containing a non-steroidal anti-inflammatory agent, comprising a support and an adhesive layer laminated on this support, wherein the adhesive layer contains a non-steroidal anti-inflammatory agent having a carboxyl group or its salt, and polyethylene glycol having an average molecular weight of 1000 or more.Type: GrantFiled: March 18, 2004Date of Patent: October 11, 2011Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Yasunori Takada, Koji Tanaka, Kiyomi Tsuruda
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Publication number: 20110244022Abstract: A composition suitable for use in a transdermal delivery patch for administration of an opioid, the composition comprising a phosphate compound of tocopherol and a polymer carrier.Type: ApplicationFiled: May 18, 2010Publication date: October 6, 2011Applicant: PHOSPHAGENICS LIMITEDInventors: Jeremy Cottrell, Giacinto Gaetano, Mahmoud El-Tamimy, Nicholas Kennedy, Paul David Gavin
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Publication number: 20110244023Abstract: A composition suitable for use in a transdermal delivery patch for administration of a biologically active compound, the composition comprising a phosphate compound of tocopherol and a polymer carrier.Type: ApplicationFiled: May 18, 2010Publication date: October 6, 2011Applicant: PHOSPHAGENICS LIMITEDInventors: Jeremy Cottrell, Giacinto Gaetano, Mahmoud El-Tamimy, Nicholas Kennedy, Paul David Gavin
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Patent number: 8029820Abstract: A patch containing tulobuterol in the low concentration and having the stable release-controllability, prepared by laminating an adhesive layer consisting of a rubber, an adhesive resin and a plasticizer on a backing, wherein 1 to 4 w/w % of tulobuterol in the lower concentration as an active ingredient and 0.1 to 3 w/w % of a higher fatty acid as a drug-releasing controlling agent are contained in the adhesive layer.Type: GrantFiled: June 16, 2004Date of Patent: October 4, 2011Assignee: Teikoku Seiyaku Co., Ltd.Inventors: Sadanobu Shirai, Masahiro Yamaji, Osamu Yoshimoto, Mamoru Naruse, Kenichi Hattori, Takako Sueda
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Patent number: 8025898Abstract: A composition for transdermal administration resulting from an admixture includes: a therapeutically effective amount of a drug that includes a parent drug and a prodrug; and a pharmaceutically acceptable carrier, wherein the parent drug and prodrug are individually present in an amount sufficient for a pharmacological effect. In a preferred embodiment, the admixture includes: a therapeutically effective amount of a pharmaceutically active agent that includes a corresponding steroid and a steroid derivative; and a carrier for the pharmaceutically active agent. The steroid and the corresponding steroid derivative are present in a weight ratio of 10:1 to 1:10 steroid: corresponding steroid derivative. In a preferred embodiment ratio is 6:1 to 1:6. In a preferred embodiment, the corresponding steroid derivative is a steroid ester. In another preferred embodiment, the carrier is a polymer that includes a pressure-sensitive adhesive.Type: GrantFiled: October 31, 2007Date of Patent: September 27, 2011Assignee: Noven Pharmaceuticals, Inc.Inventors: David Houze, Viet Nguyen
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Patent number: 8025886Abstract: The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.Type: GrantFiled: August 15, 2006Date of Patent: September 27, 2011Assignee: Vegenics Pty LtdInventors: Kari Alitalo, Tuomas Tammela, Salla Keskitalo, Katri Pajusola, Markku M. Jeltsch, Seppo Yla-Herttuala, Terhi Karpanen, Ulf Eriksson, Marko J. T. Uutela
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Patent number: 8022266Abstract: A therapeutic device for promoting the healing of a wound in a mammal is disclosed. An exemplary device comprises a permeable structure having a plurality of depressions formed in a surface thereof. In use, the surface having the depressions is disposed adjacent a surface of the wound. A method of treating a wound comprises the steps of providing a permeable structure comprising a plurality of randomly disposed fibers and having i) a plurality of wound surface contact elements disposed between end portions of the structure, and ii) a plurality of voids defined by the contact elements; and applying the permeable structure to at least one surface of the wound.Type: GrantFiled: May 20, 2009Date of Patent: September 20, 2011Assignee: Boehringer Technologies, L.P.Inventors: John R. Boehringer, John Karpowicz, Amitabha Mitra, Christopher L. Radl
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Publication number: 20110223237Abstract: The present invention provides an adhesive preparation, which includes a backing and a pressure-sensitive adhesive layer formed on at least one side of the backing, the pressure-sensitive adhesive layer containing (?)-(R)—N,?-dimethyl-N-2-propynylphenethylamine and/or a pharmaceutically acceptable salt thereof, a pressure-sensitive adhesive, an antioxidant and a metal hydroxide.Type: ApplicationFiled: March 11, 2011Publication date: September 15, 2011Applicants: NITTO DENKO CORPORATION, FUJIMOTO CO., LTD.Inventors: Eri NISHIURA, Satoshi AMEYAMA, Koji NAKAMURA, Keigo INOSAKA, Mitsuhiko HORI
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Patent number: 8017146Abstract: A device for the transdermal delivery of a pharmacologically active substance has first and second superimposed mutually contacting adhesive layers (2, 3). The first layer (3) is in use brought into contact with the skin. The active substance is dissolved in both layers, the affinity of the first layer for the active substance being between about 1.15 and about 10 times lower than that of the second layer. The percent saturation of the active substance in both the layers is the same and is less than 100%. The first layer has a greater thickness than the second layer. The device is simple and can provide stable delivery over a long period.Type: GrantFiled: May 15, 2003Date of Patent: September 13, 2011Assignee: Amarin Technologies S.A.Inventors: Francisco Jose Evaristo Stefano, Alejandro Fabio Scasso
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Patent number: 8016810Abstract: An intradermal or transdermal delivery system for topical administration of cosmetic agents, particularly water-soluble, poorly water-soluble, or water-insoluble cosmetic agents, in conjunction with an apparatus that generates micro-channels in the skin of a subject, is useful in treating skin conditions such as cellulite, hyper-pigmentation, skin aging, and acne.Type: GrantFiled: June 23, 2004Date of Patent: September 13, 2011Assignee: TransPharma Medical Ltd.Inventors: Galit Levin, Hagit Sacks, Sergey Rudaev
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Publication number: 20110200663Abstract: Provided is a methylphenidate patch preparation superior in the stability of a drug (methylphenidate and/or a salt thereof) in the patch preparation, skin permeability of a drug during use of the patch preparation, and methylphenidate availability. A patch preparation having a support and an adhesive layer formed on at least one surface of the support, wherein the adhesive layer contains methylphenidate and/or a salt thereof, polyisobutylene and a liquid plasticizer. The liquid plasticizer preferably has an HLB value of 1.0-3.3.Type: ApplicationFiled: February 12, 2010Publication date: August 18, 2011Inventors: Takumi Hara, Kei Tamura, Keigo Inosaka, Yuji Saeki
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Patent number: 7993654Abstract: A self-adhesive polymer matrix which comprises a polymer that forms a gel in water, water, a sea algae extract, and a monohydric or polyhydric alcohol.Type: GrantFiled: September 22, 2010Date of Patent: August 9, 2011Assignee: Beiersdorf AGInventors: Karl-Heinz Woeller, Thorsten Berg, Inge Kruse, Rainer Wolber
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Patent number: 7994382Abstract: The present invention relates to an application system for an active ingredient release system, comprising a film-form application strip, which is in each case bonded detachably to an active ingredient-containing plaster and a separate active ingredient release regulator separate there from.Type: GrantFiled: August 25, 2006Date of Patent: August 9, 2011Assignee: Gruenenthal GmbHInventors: Johannes Bartholomaeus, Heinrich Kugelmann
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Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures
Patent number: 7993671Abstract: A transdermal composition is disclosed which contains a blend of one or more polymers, one or more drugs, at least one of which has a low molecular weight and is liquid at or about room temperatures. The composition is substantially free of water and liquids which have a normal boiling point (a) optionally below processing temperatures and (b) greater than or equal to the temperature of the low molecular weight drugs. The composition does not suffer from the substantial loss of the lower molecular weight drug during production of the transdermal system. A transdermal composition is also disclosed which has one or more drugs, at least one of which has a low molecular weight and is liquid at or about room temperatures, and a polymer matrix including one or more high shear resistant polymers. The high shear resistant polymer(s) reduce the plasticizing effect of the low molecular weight drug, and has sufficient tack and shear for application to a human being.Type: GrantFiled: November 13, 2001Date of Patent: August 9, 2011Assignee: Noven Pharmaceuticals, Inc.Inventors: Juan Mantelle, David Houze -
Patent number: 7988673Abstract: A protective device having a substantially rigid casing for placement on a patient's skin, wherein the casing has a hollow interior facing the patient's skin and a lip. The casing can be spanned across its hollow interior by a membrane. The casing can have a first adhesive seal attached to a bottom surface of the lip of the casing, and a second adhesive seal attached to the top surface of the lip of the casing.Type: GrantFiled: July 14, 2005Date of Patent: August 2, 2011Assignee: Venetec International, Inc.Inventors: Clifford A. Wright, Gene Stewart
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Patent number: 7988991Abstract: A patch agent of the present invention comprises a support, and an adhesive layer laid on the support and containing an adhesive base and a drug, wherein the adhesive base contains an acrylic polymer substantially having no carboxyl and no hydroxyl in molecules thereof, and a rubber-based polymer, so as to achieve sufficiently high skin permeability of the drug and preparation properties. Accordingly, the present invention enables administration of the drug through skin to be implemented with drug administration effect at a sufficiently high level and on a stable basis.Type: GrantFiled: March 7, 2002Date of Patent: August 2, 2011Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Tetsuro Tateishi, Takaaki Terahara, Naruhito Higo
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Publication number: 20110182972Abstract: Described here are patches and methods for treating neuropathic pain. In some variations, the neuropathic pain-relieving patch comprises capsaicin or a capsaicin analog, wherein the concentration of the capsaicin or capsaicin analog is less than 1% by weight, and a penetration enhancer, wherein the patch is capable of relieving neuropathic pain over a sustained period of time. The penetration enhancer may be any suitable penetration enhancer. The patches may also include oils, viscosity increasing agents, and the like. In some variations, the pain-relieving patches comprise capsaicin, or an, wherein the concentration of the capsaicin or analog is less than 1%, and a penetration enhancer, whereby delivery of capsaicin from the patch continues for at least an hour, and whereby a single use of the patch provides a therapeutic benefit for at least one month, two months, or three months. Methods for treating neuropathic pain are also described.Type: ApplicationFiled: April 8, 2011Publication date: July 28, 2011Applicant: NeurogesX, Inc.Inventor: Keith R. Bley
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Patent number: 7979118Abstract: A low frequency generating poultice includes a poultice sheet; a contact fabric that is adhered to a non-medicated surface of the poultice sheet; a release sheet that is attached to a medicated surface of the poultice sheet; a low frequency oscillator; a pair of left and right first through holes; a pair of left and right second through holes that are formed in the poultice sheet, the contact fabric, and the release sheet; and a left clip portion and a right clip portion that have one end fixed to a bottom surface of the low frequency oscillator and the other end passing through the pair of left and right first through holes to be coupled to the poultice sheet through the pair of left and right second through holes and electrically connected to the low frequency oscillator.Type: GrantFiled: March 19, 2008Date of Patent: July 12, 2011Inventor: Hyunjik Yum
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Patent number: 7976867Abstract: A dermal, transdermal, mucosal or transmucosal delivery device is provided. The device includes a backing layer, defining an ingredient containing reservoir, a cover for the reservoir having at least one opening therethrough, an adhesive layer and a liner layer. Upon removal of the liner layer, the device may be placed over the desired area of the skin or mucosa and adhesively applied thereto allowing the ingredients to flow from the reservoir through the at least one opening to the dermis or mucosa.Type: GrantFiled: December 12, 2003Date of Patent: July 12, 2011Assignees: Schering-Plough Healthcare Products Inc., Corium InternationalInventors: Charles E. Lundy, Gary Wynn Cleary, Adrian Louis Faasse, Michael George Marcoux, Sreenivasu Mudumba
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Publication number: 20110150975Abstract: A method is disclosed for blocking or reducing physiological reaction in a mammal to the interaction of IgE antibodies present in said mammal upon contact with the corresponding antigen, by the administration to said mammal of a therapeutically effective amount of a neurotoxin (CnT) derived from Clostridia sp.Type: ApplicationFiled: December 22, 2010Publication date: June 23, 2011Inventor: Ira Sanders
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Publication number: 20110150976Abstract: The present invention relates to a system for facilitating transdermal delivery of oligosaccharides, The system includes an apparatus that generates micro-channels in the skin of a subject and a skin patch. The patch includes a pharmaceutical composition containing an active agent of an oligosaccharide. Particularly, the oligosaccharide has 5 to 20 monosaccharide units, such as a pentasaccharide, which exerts anticoagulant activity. The system is capable of delivering the oligosaccharides into the blood circulation for treating thromboembolic diseases.Type: ApplicationFiled: September 10, 2009Publication date: June 23, 2011Inventors: Galit Levin, Hagit Sacks, Meir Stern, Galit Mazooz
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Publication number: 20110150766Abstract: A transdermal patch having a top region containing an antagonist followed by a bottom region containing an agonist, whereby the bottommost end of the bottom region is secured to the skin of the patient for delivering a prescribed dosage of agonist to the patient over a predetermined period of time, the antagonist will be released by migrating or moving from the top region through the bottom region to the patient to prevent overdose. Visual indicators are provided in the patch for changing color to separately indicate the operation of the patch, delivery of prescribed dosage, and/or overdosage.Type: ApplicationFiled: February 23, 2011Publication date: June 23, 2011Inventor: Robert B. Royds
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Patent number: 7964213Abstract: The present invention relates to a patch containing a substrate, a non-crosslinked adhesive layer (A) containing a drug laminated on one surface of the substrate and a crosslinked adhesive layer (B) laminated on the adhesive layer (A). According to the present invention, the percutaneous absorbability of the drug can be improved, and a patch free of problems such as adhesive residue and adhesive bleed can be provided.Type: GrantFiled: April 11, 2003Date of Patent: June 21, 2011Assignee: Nitto Denko CorporationInventors: Mitsuhiko Hori, Keiji Yamamoto, Kensuke Matsuoka, Yoshihisa Nakano
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Patent number: 7955677Abstract: Assemblies for the adhesive attachment to the skin or mucosa of a host are disclosed. The assembly or transdermal patch includes an outer backing layer, a first layer of adhesive on the inner surface of the outer backing layer, an inner backing layer, and an intermediate release liner between the first layer of adhesive and the inner backing layer. The intermediate release liner includes a releasable surface on both its inner and outer surfaces.Type: GrantFiled: December 7, 2005Date of Patent: June 7, 2011Assignee: Mylan Technologies, Inc.Inventors: Brad L. Barnett, Martin Fletcher, Kenneth J. Miller, II
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Publication number: 20110129522Abstract: A transdermal patch formulation of a viscous liquid that includes an active agent of incretin or incretin mimetic peptide, a stabilizer, a buffer, a water soluble thickening agent, and a pharmaceutically acceptable carrier. Also, a patch adapted for transdermal delivery of the active agent and having a drug reservoir compartment of the transdermal patch formulation and a system for facilitating transdermal delivery of the active agent through the skin of a subject. The system includes the patch and an apparatus capable of generating a plurality of micro-channels in an area on the subject's skin. The patch and apparatus are used in methods of treatment for reducing blood glucose level, lowering plasma glucagon levels, reducing food intake, or reducing gastric motility in a subject in need of the same by extending the release of the incretin or incretin mimetic peptide in the subject.Type: ApplicationFiled: July 21, 2009Publication date: June 2, 2011Applicant: Transpharma Medical Ltd.Inventors: Keren Mevorat-Kaplan, Galit Levin, Hagit Sacks, Meir Stern
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Publication number: 20110129521Abstract: A pharmaceutical composition for induction therapy which has a hypomethylating agent and a histone deacetylase inhibitor (“HDAC inhibitor”); wherein the hypomethylating agent is a DNA and histone methylation inhibitor such as cladribine and the HDAC inhibitor is, for example, entinostat, panobinostat, vorinostat, and/or romedepsin; further wherein the hypomethylating agent and the HDAC inhibitor are combined in formulations for various administrations including e.g., a continuous delivery system such as a transdermal patch of at least one reservoir or a plurality of reservoirs, oral, a fixed-dose oral combination, intravenous, and combinations thereof. This pharmaceutical composition for induction therapy is used with a monoclonal antibody in the treatment of various cancers, sarcomas, and other malignancies.Type: ApplicationFiled: April 29, 2010Publication date: June 2, 2011Applicant: NIMBLE EPITECH, LLCInventors: Elliot M. Epner, Luke M. Vaughan
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Patent number: 7951853Abstract: The present invention relates to antimicrobial agents, methods for the production of these agents, and the use of these agents. The antimicrobial agent of the present invention includes a water-soluble polymer and oligodynamic metal ions which interact with counter-ions of the polymer such that the metal ions are bound to corresponding counter-ions. The water-soluble polymer controls a sustained release of the metal ions. The oligodynamic metal ions preferably include small size metal particles (e.g., nano-sized silver particles) that interact to the water-soluble polymer as well as metal ions derived from one or more water-soluble oligodynamic metal compositions (e.g., metal sulfates and/or metal nitrates). The agent may also include one or more acids, including organic acids (such as sulfates, carboxylic acids, amines, hydroxyls, nitrates, and phosphates) and/or non-organic acids (such as boric acid and dioctylborate).Type: GrantFiled: November 9, 2006Date of Patent: May 31, 2011Assignee: Smart Anti-Microbial Solutions, LLCInventors: Ashraf A. Ismail, Leonard Pinchuk, Orley R. Pinchuk, David Pinchuk
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Patent number: 7951395Abstract: The invention relates to a dermal for aminolaevulinic acid, wherein a self-adhesive matrix system is used containing crystalline aminolaevulinic acids.Type: GrantFiled: July 13, 2001Date of Patent: May 31, 2011Assignee: Photonamic GmbH & Co. KGInventors: Geoffrey Lee, Rolf-Markus Szeimies
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Patent number: 7947304Abstract: The invention encompasses a transdermal patch formulation comprising hGH, at least one sugar, one amino acid or polyol, and a buffer, wherein the buffer maintains the pH of the formulation in the range of about 5 to about 9 and the formulation does not contain both glycine and mannitol.Type: GrantFiled: November 2, 2006Date of Patent: May 24, 2011Assignee: TransPharma Medical Ltd.Inventors: Hagit Sacks, Meir Stern
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Publication number: 20110111013Abstract: What is disclosed is a transdermal therapeutic system for administration of an active ingredient through the skin, comprising: (a) a back layer, (b) a reservoir present on the back layer, comprising the active ingredient, polyisobutylene, a gel former and a plasticizer, a portion of the active ingredient in the reservoir being present in the form of undissolved particles and the content of gel formers in the reservoir being at most 4% by weight (based in the total weight of the reservoir), the active ingredient being Fentanyl or an analogue thereof.Type: ApplicationFiled: April 24, 2009Publication date: May 12, 2011Applicant: ACINO AGInventors: Nouha Salman, Ingo Teutsch
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Patent number: 7939100Abstract: The present invention provides a tulobuterol adhesive patch comprising (a) a support, (b) an acrylic pressure-sensitive adhesive layer containing the percutaneously absorbing drug tulobuterol and if necessary a lipophilic oily plasticizer, and (c) a release liner, laminated in that order, wherein the acrylic pressure-sensitive adhesive is a copolymer obtained by copolymerizing an acrylic monomer which is acetoacetoxyalkyl (meth) acrylate with one or more other vinyl monomers, to yield a tulobuterol adhesive patch with excellent release and skin permeability of tulobuterol from the pressure-sensitive adhesive layer, low skin irritation and excellent safety.Type: GrantFiled: December 21, 2004Date of Patent: May 10, 2011Assignee: Saitama Daiichi Pharmaceutical Co., Ltd.Inventors: Naohisa Kawamura, Hidenori Sawada, Yoshiki Sugizaki, Takashi Saitoh
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Publication number: 20110104246Abstract: A pharmaceutical composition and method for topical wound treatment by topical treatment with gallium salts, preferably gallium nitrate. In a preferred embodiment, the gallium nitrate is in an aqueous form without coagulation inhibitors such as citrate. The aqueous gallium salt formulation may be administered by a variety of methods including spraying, topical lotions, topical foams, and/or bandages containing or packaged with breakable ampoules of aqueous gallium salt formulations, and liquid bandage formulations. The aqueous gallium salt formulation may additionally contain other active and inactive ingredients, such as viscosity modifying agents, foaming agents, antiseptics, antibiotics, enzymes, fibrinogen, fibrin, polymers and growth factors.Type: ApplicationFiled: October 24, 2010Publication date: May 5, 2011Inventor: Moshe Rogosnitzky
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Publication number: 20110104247Abstract: The present invention relates to a transdermally absorbable composition which is capable of retaining a ?-blocker stably for a long period. More specifically, the present invention relates to a transdermally absorbable composition for stabilizing a ?-blocker, which comprises a polymer compound having an amino group, a polyvalent carboxylic acid ester, a fatty acid ester and an acrylic polymer compound.Type: ApplicationFiled: March 25, 2009Publication date: May 5, 2011Inventors: Takeshi Ito, Miho Ishigure
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Patent number: 7935093Abstract: A disinfectant delivery system and method of providing alcohol-free disinfection to a body to be disinfected, as well as a method of infection reduction by preparation of a patient before an invasive procedure. A blended cloth comprising first fibers and second fibers is provided with the first fibers generally being greater in quantity by weight than the second fibers. A disinfectant solution impregnates the blended cloth, with the disinfectant solution having chlorhexidine gluconate as an active ingredient and having no alcohol. In the method according to the invention, at least one impregnated blended cloth is used to disinfect at least a portion of a body. A plurality of blended cloths can be provided for disinfecting discrete portions of the body.Type: GrantFiled: October 3, 2008Date of Patent: May 3, 2011Assignee: Sage Products, Inc.Inventors: Paul H. Hanifl, Thomas Keaty, Barbara T. Skiba
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Publication number: 20110097393Abstract: This invention relates to a sustained release oral and transdermal pharmaceutical formulations and delivery systems comprising lofexidine. The invention is also directed to methods of treatment comprising administering lofexidine in a sustained release manner. Such methods can involve administration of the lofexidine containing compositions described herein. Compositions of lofexidine formulated for sustained release delivery are provided. Also provided are methods for the treatment of opiate addicts, migraine, neuropathic pain, and other therapeutic indications related to lofexidine. The methods may provide treatment for a variety of conditions amenable to amelioration by lofexidine administration. The methods utilize lofexidine compositions formulated for transdermal and sustained release oral delivery for administration of lofexidine in an amount effective for the treatment of the drug indications.Type: ApplicationFiled: June 25, 2009Publication date: April 28, 2011Applicant: US WorldMeade, LLCInventor: Abeer M. Al-Ghananeem
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Publication number: 20110086086Abstract: The invention provides transdermal compositions comprising varenicline or its pharmaceutically acceptable salt or prodrug form.Type: ApplicationFiled: June 13, 2006Publication date: April 14, 2011Inventors: Barbara Alice Johnson, Carl Bernard Ziegler
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Patent number: 7923042Abstract: The present invention relates to a medicated gauze containing as active ingredient, aliantoin, a Centella asiatica extract and, optionally, an Urtica dioica extract.Type: GrantFiled: July 20, 2006Date of Patent: April 12, 2011Assignee: Svas Biosana S.R.L.Inventor: Guglielmo Cozzolino
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Patent number: 7914813Abstract: It is intended to provide an interface for a transdermal drug administration device that can supply a drug almost evenly and favorably from a plurality of projections through skin. This interface for a transdermal drug administration device has a flat plate 8. The flat plate 8 comprises a plurality of two-dimensionally arranged conical or pyramidal projections 6 capable of piercing skin and a plurality of openings 7 capable of delivering a drug which are respectively arranged in correspondence with the projections. The openings 7 are respectively arranged in proximity to their corresponding projections 6. The flat plate 8 can be made of a metal or ceramics. The ratio between the number of the openings and the number of the projections can be 1:1 to 1:2.Type: GrantFiled: February 2, 2005Date of Patent: March 29, 2011Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Hirotoshi Adachi, Seiji Tokumoto, Naruhito Higo
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Publication number: 20110064788Abstract: The invention provides transdermal patches comprising an adhesive and a composition comprising naltrexone and either methyl oleate or isopropyl myristate, a kit comprising a plurality of such transdermal patches, a composition comprising naltrexone and methyl oleate, such a composition for use as a medicament, and compositions comprising naltrexone and methyl oleate or isopropyl myristate for use in the treatment of alcoholism or opiate addiction.Type: ApplicationFiled: February 26, 2009Publication date: March 17, 2011Applicant: Syntropharma LimitedInventor: Ludwig Jan Weimann
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Patent number: 7904146Abstract: A transdermal system for the delivery of an anesthetic or other active therapeutic agent directly to a selected site of injured skin tissue by iontophoresis is disclosed, which utilizes a transdermal skin-worn patch including a donor electrode chamber containing a donor electrode and an amount of an active agent in a form suitable for transdermal delivery in electrical communication with the donor electrode and a return electrode. The patch also contains a source of electric current connected in a circuit with the donor and return electrode, a current regulating device is optionally provided in the circuit for controlling the electrical output of the patch and at least the donor electrode chamber includes a provision for absorbing a quantity of fluid associated with weepage from adjacent injured skin tissue.Type: GrantFiled: November 9, 2007Date of Patent: March 8, 2011Assignee: Travanti Pharma Inc.Inventors: Carter R. Anderson, Russell L. Morris, Robert Cohen
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Patent number: 7899681Abstract: A system for electronic management of information relating to sterilization and high level disinfection process monitoring generates electronic sterilization record for sterilized and high level disinfected loads, and optically scans sterilization monitors associated with the sterilized loads. The system stores a digital representation of each scanned sterilization monitor, and associates the digital representation with the electronic sterilization record. The electronic sterilization record also may contain a variety of information including a sterilization status data entered by a user. The system permits a user to review both the sterilization status information and the digitized representation of the sterilization monitor online to verify accuracy. In this manner, a representation of the actual sterilization monitor can be stored and retrieved when desired for verification of result, audits and other quality review activity.Type: GrantFiled: March 29, 2002Date of Patent: March 1, 2011Assignee: 3M Innovative Properties CompanyInventors: Kevin R. Katzenmaier, Janet M. Prust, Andrew C. Daus
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Patent number: 7892574Abstract: Disclosed is a method of treating a non-topical infection selected from the group consisting of ear infections, skin and soft tissue infections, acne, infected wounds, bacteremia, in a useful warm blooded mammal who is in need of such treatment which comprises topical administration of a pharmaceutical formulation containing a transdermally effective amount of an Oxazolidinone.Type: GrantFiled: September 16, 2003Date of Patent: February 22, 2011Assignee: Pharmacia & Upjohn Company, LLCInventors: Charles W. Ford, Jeffrey L. Watts
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Patent number: 7883504Abstract: The invention provides a device for a percutaneous absorption preparation, provided with a solution storage container which can exhibit good solution migration independently of the level of force. The device for a percutaneous absorption preparation comprises an electrode film comprising a base member (1) and an electrode layer (2) and having a dissolution liquid passage hole (9), a drug impregnation member (3) mounted on the electrode layer (2) side of the electrode film, and a dissolution liquid storage container (5) bonded to the base member (1) side of the electrode film via a lid member (7) covering the solution passage hole (9). The dissolution liquid storage container (5) comprises a bottom and a sidewall. A protrusion (5b) which faces the dissolution liquid passage hole (9) is provided at the center of the bottom, and the sidewall is provided with a vertically folded part (5c).Type: GrantFiled: August 31, 2007Date of Patent: February 8, 2011Assignees: Hisamitsu Pharmaceutical Co., Inc., Kyodo Printing Co., Ltd.Inventors: Seiji Tokumoto, Hirotoshi Adachi, Yasushi Fuchita, Tatsuya Ogawa, Hitoshi Otomo
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Patent number: 7883494Abstract: An apparatus for cleansing wounds in which irrigant fluid from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are moved by a device (which may be a single pump or two pumps) for moving fluid through a flow path which passes through the dressing and over a biodegradable scaffold in contact with the wound bed (which encourages healing tissue growth from the wound bed). The apparatus has means (which includes the device(s)) for providing simultaneous aspiration and irrigation of the wound. A dressing assembly including the dressing and the scaffold, and the dressing and a method of treatment using the apparatus.Type: GrantFiled: October 28, 2005Date of Patent: February 8, 2011Assignee: Smith & Nephew PLCInventor: Robin Paul Martin
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Patent number: 7883719Abstract: A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with an adhesive agent and oxybutynin and/or a pharmaceutically acceptable salt thereof, wherein the adhesive agent comprises an acrylic polymer substantially free of both carboxyl group and hydroxyl group and a rubber polymer, in which weight ratio of content of the acrylic polymer to content of the rubber polymer is from 1:4 to 1:19.Type: GrantFiled: August 7, 2003Date of Patent: February 8, 2011Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Takeshi Ito, Tetsuro Tateishi, Naruhito Higo
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Patent number: 7884258Abstract: A therapeutic device for promoting the healing of a wound in a mammal is disclosed. An exemplary device comprises a permeable structure having a plurality of depressions formed in a surface thereof. In use, the surface having the depressions is disposed adjacent a surface of the wound. A method of treating a wound comprises the steps of providing a permeable structure comprising a plurality of randomly disposed fibers and having i) a plurality of wound surface contact elements disposed between end portions of the structure, and ii) a plurality of voids defined by the contact elements; and applying the permeable structure to at least one surface of the wound.Type: GrantFiled: November 5, 2004Date of Patent: February 8, 2011Assignee: Boehringer Technologies, L.P.Inventors: John R. Boehringer, John Karpowicz, Amitabha Mitra, Christopher L. Radl
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Patent number: 7879344Abstract: The present disclosure generally relates to compositions for reducing inflammation, and more particularly, to compositions comprising oleocanthal. The oleocanthal-containing compositions are particularly suitable for transdermal delivery. The compositions may also be used in combination with personal care products, such as wipes and absorbent articles, and may be incorporated into transdermal patches.Type: GrantFiled: June 29, 2006Date of Patent: February 1, 2011Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Joseph R. Feldkamp, David William Koenig, Scott W. Wenzel, Wael Joseph
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Publication number: 20110020426Abstract: The present invention is directed to a process for manufacturing a transdermal delivery device comprising a backing layer, a release liner, and an adhesive layer between the backing layer and release liner. More specifically, the invention is directed to a process of preparing an adhesive layer, wherein the adhesive layer is comprised of polyisobutylene and an active pharmaceutical ingredient.Type: ApplicationFiled: July 19, 2010Publication date: January 27, 2011Applicant: MYLAN, INC.Inventors: Russell Adam Baird, Brad L. Barnett, Russell D. Beste
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Patent number: 7872167Abstract: An adhesive for medical patches or for transdermal therapeutic systems which contains a component or a combination of at least two components, such as (a) polyvinyl alcohols, (b) cellulose derivatives, (c) polyethers, (d) acid anhydrides and their acids and salts, as well as (e) non-pressure-sensitive adhesive polyacrylates. The adhesive has a tackiness which is activated and/or increased by contact with moisture or by absorption of moisture.Type: GrantFiled: October 31, 2003Date of Patent: January 18, 2011Assignee: LTS Lohmann Therapie-Systeme AGInventor: Marc Riemenschnitter
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Publication number: 20110008413Abstract: The present invention generally relates to transdermal drug delivery systems. More particularly, the present invention provides compositions and transdermal drug delivery systems for the treatment and/or relief of symptoms associated with carpal tunnel syndrome or tendonitis.Type: ApplicationFiled: July 7, 2010Publication date: January 13, 2011Applicant: MSK PHARMA, LLCInventors: Yong Qiu, James S. Kuo, Geraldine P. Kuo, Chin-Chih Chiang, Paul R. Chen