Organic Pressurized Fluid Patents (Class 424/45)
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Patent number: 11213501Abstract: A compounded transdermal cream for the topical administration of a compounded therapy includes a first active agent selected from the group consisting of nabumetone in an amount between approximately 5.0% and approximately 25% by weight of the transdermal cream and amitriptyline in an amount between approximately 0.5% and approximately 4.0% by weight of the transdermal cream; a second active agent comprising a nerve depressant in an amount between approximately 5.0% and 15.0% by weight of the transdermal cream, wherein the nerve depressant is gabapentin; a third active agent comprising a local anesthetic in an amount between approximately 1.0% and approximately 7.0% by weight of the transdermal cream, wherein the local anesthetic comprises lidocaine and prilocaine; and dimethyl sulfoxide (DMSO).Type: GrantFiled: August 26, 2015Date of Patent: January 4, 2022Assignee: CMPD LICENSING, LLCInventor: Jay Richard Ray, II
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Patent number: 11213500Abstract: A compounded transdermal cream for topical administration of a compounded therapy includes a nerve depressant such as gabapentin in an amount between approximately 5% and 15% by weight of the transdermal cream, an NSAID (Non-Steroidal Anti-Inflammatory Drug) such as nabumetone in an amount between approximately 5% and approximately 25% by weight of the transdermal cream, a tricyclic antidepressant such as amitriptyline in an amount between approximately 0.5% and approximately 4% by weight of the transdermal cream, a local anesthetic such as lidocaine and prilocaine in an amount between approximately 1% and approximately 7% by weight of the transdermal cream, and dimethyl sulfoxide (DMSO).Type: GrantFiled: August 26, 2015Date of Patent: January 4, 2022Assignee: CMPD LICENSING, LLCInventor: Jay Richard Ray, II
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Patent number: 11209411Abstract: The invention generally relates to methods for analyzing stability of an active pharmaceutical agent. In certain aspects, the methods involve obtaining an active pharmaceutical agent, and distributing the active pharmaceutical agent into one or more microdroplets. The one or more microdroplets including the active pharmaceutical agent are then subjected to one or more conditions that force degradation of the active pharmaceutical agent in each of the one or more microdroplets. The one or more microdroplets are then analyzed to determine a ratio of the active pharmaceutical agent to that of a degradation product of the active pharmaceutical agent, thereby analyzing stability of an active pharmaceutical agent.Type: GrantFiled: January 11, 2019Date of Patent: December 28, 2021Assignee: Purdue Research FoundationInventors: Robert Graham Cooks, Roy Helmy, Yangjie Li, Yong Liu
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Patent number: 11179366Abstract: A pharmaceutical composition is described. The composition may include: (i) a drug component including at least one pharmaceutically acceptable salt of glycopyrrolate; and (ii) a propellant component including 1,1-difluoroethane (HFA-152a).Type: GrantFiled: September 25, 2019Date of Patent: November 23, 2021Assignee: MEXICHEM FLUOR S.A. DE C.V.Inventors: Stuart Corr, Timothy James Noakes
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Patent number: 11154466Abstract: The invention relates to an aerosol device which contains a composition comprising: (i) one or more water-insoluble calcium salts, (ii) one or more fixing polymers, (iii) one or more surfactants, (iv) water, and (v) less than 20% by weight, relative to the total weight of the composition, of one or more propellants. It also relates to a process for shaping the hair and/or retaining the hairstyle, using the aerosol device of the invention.Type: GrantFiled: June 30, 2015Date of Patent: October 26, 2021Assignee: L'OREALInventors: Jonathan Gawtrey, Dorothée Pasquet
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Patent number: 11141441Abstract: Bacterial hyperswarmers are disclosed for treatment, prevention and diagnosis of conditions such as intestinal inflammation.Type: GrantFiled: September 10, 2020Date of Patent: October 12, 2021Assignee: Albert Einstein College of MedicineInventors: Sridhar Mani, Libusha Kelly, Hao Li
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Patent number: 11129775Abstract: A method of treating hair or skin with a creamy foam. The method comprises dispensing a personal care composition from a mechanical foam dispenser as a dosage of foam, applying the dosage of foam to hair or skin, and rinsing the dosage of foam from hair or skin. The personal hair composition contains a surfactant system that is substantially free of sulfate-based surfactants. The personal hair composition has a viscosity of less than 60 cP and a lather volume greater than 77 cm3.Type: GrantFiled: August 6, 2019Date of Patent: September 28, 2021Assignee: The Procter and Gamble CompanyInventors: Brian Xiaoqing Song, Ioannis Constantine Constantinides
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Patent number: 11112145Abstract: Artificial dense granules composed of a sterically stabilized liposome shell encapsulating a polyphosphate nanoparticle core are provided as are methods for their production and use in the treatment of a severe hemorrhagic event.Type: GrantFiled: September 24, 2015Date of Patent: September 7, 2021Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Ying Liu, Alexander Donovan
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Patent number: 11110077Abstract: The present invention relates to topical pharmaceutical compositions of apremilast used for the treatment of psoriasis and/or psoriatic arthritis. It further relates to processes of preparation of the compositions and the method of use for these compositions.Type: GrantFiled: September 30, 2016Date of Patent: September 7, 2021Assignee: SARUDBHAVA FORMULATIONS PRIVATE LIMITEDInventor: Venkata Nookaraju Sreedharala
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Patent number: 11110043Abstract: The use of long-chain alkenones to impart desired characteristics in personal care compositions for topical applications is described. The preparation of mixtures long-chain alkenones and synthetic derivatives thereof is presented. Examples of compositions include abrasive soaps, with alkenones serving as natural exfoliating agents. Alkenones and their derivatives can serve as emollients, occlusive agents, encapsulating agents, stabilizing agents, binding agents, thickening agents, surfactants, and antimicrobials.Type: GrantFiled: November 16, 2016Date of Patent: September 7, 2021Assignees: WWU, Woods Hole Oceanographic InstitutionInventors: Gregory W. O'Neil, Christopher M. Reddy
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Patent number: 11103480Abstract: A pharmaceutical composition is described. The composition may include: (i) a drug component including at least one pharmaceutically acceptable salt of glycopyrrolate; and (ii) a propellant component including 1,1-difluoroethane (HFA-152a).Type: GrantFiled: September 25, 2019Date of Patent: August 31, 2021Assignee: MEXICHEM FLUOR S.A. DE C.V.Inventors: Stuart Corr, Timothy James Noakes
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Patent number: 11103448Abstract: The present invention relates to particles and to methods of making particles. In particular, the invention relates to methods of making composite active particles comprising a pharmaceutically active material for pulmonary inhalation, the method comprising a jet milling process.Type: GrantFiled: February 23, 2018Date of Patent: August 31, 2021Assignee: VECTURA LIMITEDInventors: David Morton, John Staniforth
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Patent number: 11077076Abstract: A pharmaceutical composition is described. The composition comprises: (i) a drug component comprising at least one salmeterol compound selected from salmeterol and the pharmaceutically acceptable derivatives thereof; and (ii) a propellant component comprising 1,1-difluoroethane (HFA-152a).Type: GrantFiled: May 26, 2020Date of Patent: August 3, 2021Assignee: MEXICHEM FLUOR S.A. DE C.V.Inventors: Stuart Corr, Timothy James Noakes
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Patent number: 11046641Abstract: The present disclosure is directed in part to methods of treating fibrosis, e.g., hepatic fibrosis and/or intestinal fibrosis, comprising administering to a patient in need thereof an effective amount of a disclosed compound.Type: GrantFiled: May 12, 2017Date of Patent: June 29, 2021Assignee: Nogra Pharma LimitedInventors: Sergio Baroni, Salvatore Bellinvia, Francesca Viti
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Patent number: 11033494Abstract: A method for preparing a card containing at least one sequestered compound is provided. The method includes preparing a first waxy phase, preparing a first volatile phase comprising a first sequestered compound, creating a first emulsion from the first waxy phase and the first volatile phase, depositing the first emulsion on the card, and cooling the first emulsion.Type: GrantFiled: September 30, 2015Date of Patent: June 15, 2021Assignee: Recursion Pharmaceuticals, Inc.Inventors: Jonathan Noble Betts-Lacroix, Daniel Ford, Laura Schaevitz
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Patent number: 11028398Abstract: A fusion protein having a non-immunoglobulin polypeptide having a cysteine residue proximal to the C terminal thereof, and an immunoglobulin component with a mutated hinge region is provided. The mutation comprises a point mutated site corresponding in position to the position in a native hinge region of the cysteine residue located nearest the cysteine residue of the non-Ig component. The distance from the cysteine residue of the non-immunoglobulin polypeptide and any remaining cysteine residues of the mutated hinge region is sufficient to prevent the formation of a disulphide bond therebetween.Type: GrantFiled: October 17, 2011Date of Patent: June 8, 2021Assignee: NOVAGEN HOLDING CORPORATIONInventors: Haitao Wang, Yong Du, Rui Zhang, Jing Xu, Longbin Liu
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Patent number: 11020542Abstract: A process and a nebulizer for dispensing a consecutively dose of medicament in the form of a mist, comprising: an energy source (ES), an air-conditioning volume, an air outlet fluidity connected to the air-containing volume, an air actuator adapted to release a flow of compressed air through the air outlet at such time as a predetermined ES pressure has been reached in the volume and at least two valve means in communication with the air actuator. The compressed air is released at a predetermined pressure of about 20 to about 100 psig. The valve means controls the actuation of the air actuator such that when a medication is nebulized, a mist distribution of a medication is formed having droplets size in the range of approximately 1? to approximately 7? which inhaled by a user at a set of predetermined intervals.Type: GrantFiled: July 3, 2014Date of Patent: June 1, 2021Assignee: Sanara Tech Ltd.Inventors: Eran Eilat, Joshua Altman
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Patent number: 11020384Abstract: Pharmaceutical compositions comprising an antiarrhythmic agent for treatment of a heart condition via inhalation. Methods of treating a heart condition include administering by inhalation an effective amount of at least one antiarrhythmic pharmaceutical agent to a patient in need thereof. Nebulized drug product and kits are also disclosed.Type: GrantFiled: June 15, 2020Date of Patent: June 1, 2021Assignee: InCarda Therapeutics, Inc.Inventors: Michael Laird Hurrey, Luiz Belardinelli, Prashanti Madhavapeddi, Carlos Schuler
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Patent number: 11007185Abstract: Pharmaceutical compositions comprising an antiarrhythmic agent for treatment of a heart condition via inhalation. Methods of treating a heart condition include administering by inhalation an effective amount of at least one antiarrhythmic pharmaceutical agent to a patient in need thereof. Nebulized drug product and kits are also disclosed.Type: GrantFiled: June 15, 2020Date of Patent: May 18, 2021Assignee: InCarda Therapeutics, Inc.Inventors: Michael Laird Hurrey, Luiz Belardinelli, Prashanti Madhavapeddi, Carlos Schuler
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Patent number: 11007150Abstract: The inventive subject matter relates to a pharmaceutical aerosol product suitable for administration by oral or nasal inhalation and its use in the treatment of respiratory diseases, in particular in the treatment of children.Type: GrantFiled: August 13, 2012Date of Patent: May 18, 2021Assignee: COVIS PHARMA GMBHInventors: Helgert Muller, Renate Engelstatter, Ulrich Bildmann, Andrea Bauer, Paul Mcglynn
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Patent number: 10987288Abstract: A deep-sea water concentrate skin application kit of deep-sea active concentrate and skincare formula is provided. The deep-sea water concentrate skin application kit has the following properties of micronizing the skincare formulas immediately, and decreasing the surface tension of the deep-sea active concentrate immediately; furthermore, the deep-sea active concentrate can become a driving force for the permeability of the micronized skincare formulas. Therefore, the deep-sea water concentrate skin application kit can be more easily absorbed into the skin (dermis). A manufacturing method of the deep-sea water concentrate skin application kit is also provided to improve skin appearance.Type: GrantFiled: December 7, 2018Date of Patent: April 27, 2021Inventors: Yin-Ming Lo, Jane-Yi Su
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Patent number: 10980920Abstract: Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).Type: GrantFiled: March 16, 2018Date of Patent: April 20, 2021Assignee: Arsenal Medical, Inc.Inventors: Upma Sharma, Irina Gitlin, Gregory T. Zugates, Adam Rago, Parisa Zamiri, Rany Busold, Robert J. Caulkins, Toby Freyman, Quynh Pham, Changcheng You, Jeffrey Carbeck
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Patent number: 10973763Abstract: Inhalable pharmaceutical compositions can include an aqueous dispersion of particles including a hydrophobic bioactive agent (e.g., CoQ10) suitable for continuous aerosolization. Due to their chemical composition and methods of manufacture, the pharmaceutical compositions exhibit distinctive physicochemical properties that provide advantageous aerosol transmission and output.Type: GrantFiled: June 18, 2012Date of Patent: April 13, 2021Assignee: Berg LLCInventors: Niven Rajin Narain, John Patrick McCook
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Patent number: 10966925Abstract: The present invention is directed to epinephrine spray formulations. The present invention is further directed to methods of treating anaphylaxis by administering epinephrine spray formulations to subjects in need of such treatments.Type: GrantFiled: January 4, 2019Date of Patent: April 6, 2021Assignee: HIKMA PHARMACEUTICALS USA INC.Inventors: Thrimoorthy Potta, Craig Bastian, Ningxin Yan, Venkat Goskonda, Chandeshwari Chilampalli, Rachana Inavolu, Eshwaran Narayanan
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Patent number: 10945950Abstract: The present invention relates to a liquid pharmaceutical composition suitable for administration by inhalation which comprises a diluent and a suspension of particles of 9,10-dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one (RPL554) or a pharmaceutically acceptable salt thereof. Also described is a liquid pharmaceutical composition according to the invention for use in the treatment of the human or animal body.Type: GrantFiled: March 21, 2018Date of Patent: March 16, 2021Assignee: VERONA PHARMA PLCInventors: Peter Lionel Spargo, Edward James French, Phillip A. Haywood
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Patent number: 10933019Abstract: The present invention relates to liquid pharmaceutical compositions comprising daptomycin, methods of providing such compositions and the use thereof. Provided herein are formulations comprising daptomycin, one or more polar protic solvents, and mixtures thereof. Formulations according to the present invention can further comprise polar aprotic solvent and/or source of calcium.Type: GrantFiled: October 17, 2017Date of Patent: March 2, 2021Assignee: XELLIA PHARMACEUTICALS APSInventors: Tina Gjoni, Dubravka Strazic
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Patent number: 10933018Abstract: Provided herein are novel isotretinoin formulations that provide an enhanced targeted dermal delivery system for the drug isotretinoin with improved thermodynamic activity using no to a small level of ethanol relative to existing isotretinoin gel products, and methods for treatment of ichthyosis and other skin conditions using the same.Type: GrantFiled: October 26, 2016Date of Patent: March 2, 2021Assignee: Timber Pharmaceuticals LLCInventors: Zachary Rome, Charles Rodney Greenaway Evans, Marc Barry Brown, Francesco Caserta
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Patent number: 10925924Abstract: Disclosed is a dry-powder peptide medicament with a non-typical concentration of carbohydrate excipient, as well as said medicament for use in treatment or prevention of a disease or condition, as well as methods for manufacturing said medicament.Type: GrantFiled: March 17, 2015Date of Patent: February 23, 2021Assignee: APEPTICO FORSCHUNG UND ENTWICKLUNG GMBHInventor: Bernhard Fischer
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Patent number: 10925689Abstract: The present invention relates to nitric oxide (NO)-releasing nail coating compositions, NO-releasing coatings, and methods of using the same, for example, to treat fungal infections of a nail. It is noted that aspects described with respect to one embodiment may be incorporated in different embodiments although not specifically described relative thereto. Provided according to embodiments of the invention are nitric oxide (NO)-releasing nail coating compositions and/or coatings.Type: GrantFiled: July 14, 2015Date of Patent: February 23, 2021Assignee: Novan, Inc.Inventors: Ryan Doxey, Yong Zhang
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Patent number: 10905697Abstract: The application provides formulations for the topical administration of an active agent comprising at least one steroid, in the form of topical sprays that are propellant-free, and/or substantially non-foaming, and/or alcohol-free. The present application also provides processes for preparing such compositions and methods of using them in management of skin diseases or disorders such as psoriasis, dermatoses, and other associated skin diseases or disorders.Type: GrantFiled: January 29, 2020Date of Patent: February 2, 2021Assignee: Encore Dermatology, Inc.Inventors: Udhumansha Ubaidulla, Sateesh Kandavilli, Ajay Sunil Vairale, Jeffrey A. Wayne, Vijendra Nalamothu, Mistry Meghal, Refika Isil Pakunlu
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Patent number: 10894775Abstract: In its many embodiments, the present invention provides certain piperidine compounds of the Formula (I): and pharmaceutically acceptable salts thereof, wherein X, Y, R1, R2, R3, L, R4, L1, Q, and R5 are as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-? receptor (LXR?) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.Type: GrantFiled: October 9, 2017Date of Patent: January 19, 2021Assignee: Merck Sharp & Dohme Corp.Inventors: Michael T. Rudd, Zhaoyang Meng, Jenny Wai, David Jonathan Bennett, Edward J. Brnardic, Nigel J. Liverton, Shawn J. Stachel, Yongxin Han, Paul Tempest, Jiuxiang Zhu, Xuewang Xu, Bin Zhu, Chuanman Huang
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Patent number: 10888546Abstract: A pharmaceutical composition is described. The composition comprises: (i) a drug component comprising at least one pharmaceutically acceptable salt of giycopyrrolate; and (ii) a propellant component comprising 1,1-difluoroethane (HFA-152a).Type: GrantFiled: September 18, 2017Date of Patent: January 12, 2021Assignee: MEXICHEM FLUOR S.A. DE C.V.Inventors: Stuart Corr, Timothy James Noakes
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Patent number: 10889736Abstract: A polymer that can be used as a release coating or a release agent in an LAB, either of which can be provided in VOC-free form and which exhibits excellent release even after aging under high humidity, includes mer that contain pendent groups that include carbamate functionalities.Type: GrantFiled: March 30, 2015Date of Patent: January 12, 2021Assignee: OMNOVA Solutions Inc.Inventor: Joel E. Goldstein
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Patent number: 10877024Abstract: The invention provides novel methods of determining or comparing potency of a test interferon relative to rSIFN-co (an interferon having therapeutic effects on solid tumors); methods of establishing substantial equivalence between a test interferon and rSIFN-co; as well as methods for determining potency of a test interferon, kits for determination of such methods, and an interferon or an interferon substitute having said activities.Type: GrantFiled: May 11, 2016Date of Patent: December 29, 2020Assignee: SUPERLAB FAR EAST LIMITEDInventor: Guangwen Wei
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Patent number: 10869913Abstract: A system for delivering a therapeutic agent to a nasopharyngeal mucosa target comprises a foam generating mechanism, a gas, a therapeutic agent in liquid form that inhibits mucus production, and a delivery device. Actuation of the foam generating mechanism entraps gaseous bubbles from the gas in the liquid thereby forming a foam. The therapeutic agent is dispersed in the foam which has an expanded configuration adapted to fill a nasopharyngeal space and deliver the therapeutic agent to the mucosa targets. The delivery device is for delivering the foam to the nasopharyngeal space. The foam may also have a collapsed configuration for removal from the nasopharyngeal space or for concentration of the therapeutic agent onto the mucosa.Type: GrantFiled: May 24, 2018Date of Patent: December 22, 2020Assignee: The Foundry, LLCInventors: John Morriss, Cary Reich, Hanson Gifford
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Patent number: 10857159Abstract: The present invention provides a composition and method for treating various skin diseases. The composition is formulated as a foamable composition and includes the corticosteroid halobetasol.Type: GrantFiled: November 30, 2016Date of Patent: December 8, 2020Assignee: MAYNE PHARMA LLCInventors: Robert T. Gauthier, James D. Hammer
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Patent number: 10842845Abstract: The present disclosure provides methods for treating obstructive sleep apnea (OSA) and OSA induced cardiorespiratory diseases. The disclosure provides, inter alia, methods for treating or alleviating: OSA or OSA induced hypertension, cardiac arrhythmias, myocardial ischemia, sudden cardiac death or stroke, by administering oxytocin. The disclosure further provides methods for improving sleep satisfaction in OSA patients by administering oxytocin.Type: GrantFiled: November 8, 2018Date of Patent: November 24, 2020Assignee: THE GEORGE WASHINGTON UNIVERSITYInventors: David Mendelowitz, Vivek Jain, Heather Jameson, Jay Shawn Kimbro
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Patent number: 10835738Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.Type: GrantFiled: August 10, 2017Date of Patent: November 17, 2020Assignee: Oculeve, Inc.Inventors: Douglas Michael Ackermann, James Donald Loudin, John Wardle, Janusz Kuzma
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Patent number: 10829543Abstract: The presently-disclosed subject matter relates to antibodies, compositions, and methods for inhibiting and treating virus infection in the respiratory tract and virus transmission through the respiratory tract. In particular, the presently-disclosed subject matter relates to inhibiting and treating virus infection in a subject using compositions and antibodies that trap viruses in mucus of the respiratory tract, thereby inhibiting transport of virus across or through mucus secretions.Type: GrantFiled: September 21, 2018Date of Patent: November 10, 2020Assignees: The University of North Carolina at Chapel Hill, The Johns Hopkins UniversityInventors: Samuel Lai, Ying-Ying Wang, Arthi Kannan, Kenetta Nunn, Durai Babu Subramani, Richard Cone, Bing Yang, Justin Mccallen
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Patent number: 10806769Abstract: A topical cleansing composition for stimulating the production of antimicrobial peptides on the skin is disclosed. The topical cleansing composition includes an active ingredient comprising one or more of a natural extract and a polypeptide; one or more surfactants; and water. The topical cleansing composition increases the concentration of antimicrobial peptides on skin, as compared to an otherwise identical topical composition without the active ingredient.Type: GrantFiled: March 31, 2017Date of Patent: October 20, 2020Assignee: GOJO Industries, Inc.Inventors: Kegui Tian, Jessica Rae Tittl, Venkatesan V. Padyachi
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Patent number: 10806701Abstract: Stable aerosol solution formulations comprising glycopyrronium bromide are useful for administration to patients with COPD and other respiratory conditions.Type: GrantFiled: July 6, 2015Date of Patent: October 20, 2020Assignee: CHIESI FARMACEUTICI S.p.A.Inventors: Sauro Bonelli, Francesca Usberti, Enrico Zambelli
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Patent number: 10792256Abstract: A pharmaceutical composition is described. The composition comprises: (i) a drug component comprising at least one salmeterol compound selected from salmeterol and the pharmaceutically acceptable derivatives thereof; and (ii) a propellant component comprising 1,1-difluoroethane (HFA-152a).Type: GrantFiled: September 18, 2017Date of Patent: October 6, 2020Assignee: MEXICHEM FLUOR S.A. DE C.V.Inventors: Stuart Corr, Timothy James Noakes
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Patent number: 10785998Abstract: A combination of a method using a composition utilized together to disinfect and/or lubricate a fluid encompassing system. A single composition comprising a disinfectant and a lubricant comprises water-alcohol-glycerin-chlorhexidine gluconate. This composition is used together with a method of purging this fluid encompassing system, adding said composition into said system, and flushing/rinsing said system. This method ensures that this composition is not diluted and that this composition directly contacts the microbial contamination and biofilm in this system. This method using this composition maintains and controls this system's encompassing fluid chemical and physical properties by disinfecting and/or lubricating said fluid encompassing system and said system's fluid system components comprising of fluid conduit(s), and/or fluid reservoir(s), and/or valve(s), and/or device(s) that connect to this system's fluid system.Type: GrantFiled: October 25, 2017Date of Patent: September 29, 2020Inventors: Thad J. Overmyer, Michael Overmyer
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Patent number: 10751483Abstract: A medicament delivery device has a syringe, a housing, a needle shield, a biasing member and one or more blocking members. The needle shield is biased axially forwardly by the biasing member so as to selectively cover a needle of the syringe. However, the biasing member is prevented from biasing the needle shield axially forwardly until a radial movement of the blocking members has occurred, which is precipitated by a forward axial movement of the syringe. Consequently, the forward movement of the syringe releases the needle shield to automatically make safe the device.Type: GrantFiled: April 21, 2016Date of Patent: August 25, 2020Assignee: Consort Medical PLCInventors: Steven Hatch, Alastair Willoughby, Guy Moseley, Dan Garson
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Patent number: 10736343Abstract: An antimicrobial composition for extending the shelf-life of water, feed or feed ingredients, comprising: water, a mixture of CrC18 organic acids, a mixture of CrC24 aldehydes, 5-25 wt. % pelargonic acid, and 5-30 wt. % trans-2-hexenal.Type: GrantFiled: October 8, 2012Date of Patent: August 11, 2020Assignee: ANITOX CORPORATIONInventors: Julio Pimentel, Kurt Richardson
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Patent number: 10682343Abstract: The present invention features compositions and methods for treatment of snoring. We describe compositions comprising an antihistamine or a pharmaceutically acceptable salt thereof and one or more dietary supplements or pharmaceutically acceptable salts thereof. The compositions can be administered to a subject suffering from snoring.Type: GrantFiled: February 10, 2017Date of Patent: June 16, 2020Inventors: James M. Hand, Linda M. Hand
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Patent number: 10682414Abstract: Drug products adapted for nasal delivery comprising formulations with epinephrine and devices comprising such formulations are provided. Methods of treating anaphylaxis with epinephrine products are also provided.Type: GrantFiled: May 22, 2019Date of Patent: June 16, 2020Assignee: AEGIS THERAPEUTICS, LLCInventors: Richard Lowenthal, Edward T. Maggio, Robert G. Bell, Pratik Shah
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Patent number: 10677782Abstract: The invention provides novel methods of determining or comparing potency of a test interferon relative to rSIFN-co (an interferon having therapeutic effects on solid tumors); methods of establishing substantial equivalence between a test interferon and rSIFN-co; methods for down-regulation of expression of Wnt-related receptors or co-receptors, such as LRP6/FZD6; down-regulation of expression of Wnt-related target genes, such as, Axin2, CD24, Survivin and/or ID2; inhibition of beta-catenin/TCF transcriptional activities; suppression of expression of beta-catenin; up-regulation of tumor suppressor genes, such as DKK-3, BATF2 and/or KLF4; inhibition of tumor cell viability in vitro; inhibition of tumor growth and metastases in vivo; inhibition of tumor cell migration, pseudopod formation, and colony formation in vitro; as well as methods for determining potency of a test interferon, kits for determination of such methods, and an interferon or an interferon substitute having said activities.Type: GrantFiled: November 12, 2014Date of Patent: June 9, 2020Assignee: SUPERLAB FAR EAST LIMITEDInventor: Guangwen Wei
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Patent number: 10674722Abstract: Antimicrobial and foamable alcoholic compositions, where the compositions include at least about 40 wt. % of a C1-4 alcohol and one or more silane surfactants selected from (1) zwitterionic silane surfactants, (2) polyalkoxylated silane surfactants that contain at least one silane group and at least one polyalkylene oxide chain.Type: GrantFiled: November 1, 2018Date of Patent: June 9, 2020Assignee: GOJO Industries, Inc.Inventors: Evan D. Hillman, Daniel J. Lacks, Mitchell J. Cohen
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Patent number: 10668018Abstract: A pharmaceutical solution for a medication delivery apparatus, especially a metered dose inhaler, is described. The pharmaceutical solution comprises: (a) a liquefied propellant component consisting essentially of and preferably consisting entirely of 1,1-difluoroethane (R-152a); (b) ethanol; and (c) a drug component dissolved in the propellant/ethanol mixture consisting of at least one drug selected from the group consisting of beclomethasone dipropionate (BDP) and fluticasone propionate (FP).Type: GrantFiled: January 16, 2019Date of Patent: June 2, 2020Assignee: MEXICHEM AMANCO HOLDING S.A. DE C.V.Inventors: Stuart Corr, Timothy James Noakes