Containing Polysaccharide (e.g., Sugar, Etc.) Patents (Class 424/479)
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Patent number: 12059397Abstract: The invention relates to pharmaceutical compositions comprising calcium lactate as an active agent and a polysaccharide, polymer, lipid, or a combination thereof. The pharmaceutical compositions are useful treating cancer. The invention also relates to foods and nutrient compositions comprising calcium lactate.Type: GrantFiled: February 24, 2022Date of Patent: August 13, 2024Assignee: METIMEDI PHARMACEUTICALS CO., LTD.Inventors: Chong Hwan Chang, Keun-Yeong Jeong
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Patent number: 12016955Abstract: A free-flowing solid pharmaceutical formulation comprising one or more active ingredients and a blend comprising sorbitol and liquid paraffin, a package containing the formulation, a process for the manufacture of the formulation and the use of the blend in the formulation.Type: GrantFiled: March 30, 2023Date of Patent: June 25, 2024Assignee: Ferring B.V.Inventors: Ganeshchandra Sonavane, Parag Lokhande, Pradeep Sethi, Tushar Wagh
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Patent number: 11998639Abstract: The present invention relates to immediate release formulations of (R)-2-amino-3-phenylpropyl carbamate and methods of using the same to treat disorders.Type: GrantFiled: September 2, 2022Date of Patent: June 4, 2024Assignee: AXSOME MALTA LTD.Inventors: Clark Patrick Allphin, Edwin Gerard Walsh
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Patent number: 11696900Abstract: The invention discloses a composition exhibiting enhanced bioavailability comprising tri-molecular complex of a natural compound or a natural compound containing component, a divalent or tri-valent metal ion and a phospholipid embedded in natural matrix. The composition of the invention further exhibits a sustained release profile for the natural compound or natural compound containing component. The invention further discloses a process for manufacturing the tri-molecular complex containing composition.Type: GrantFiled: December 16, 2016Date of Patent: July 11, 2023Assignee: OLENE LIFE SCIENCES PRIVATE LIMITEDInventors: Vivek Anand Parachur, Somashekara Nirvanashetty
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Patent number: 11439597Abstract: The present invention relates to immediate release formulations of (R)-2-amino-3-phenylpropyl carbamate and methods of using the same to treat disorders.Type: GrantFiled: January 21, 2021Date of Patent: September 13, 2022Assignee: Axsome Malta Ltd.Inventors: Clark Patrick Allphin, Edwin Gerard Walsh
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Patent number: 11400065Abstract: Oral pharmaceutical compositions of sodium oxybate having improved pharmacokinetic properties when administered less than two hours after eating are provided, and therapeutic uses thereof.Type: GrantFiled: February 28, 2020Date of Patent: August 2, 2022Assignee: Flamel Ireland LimitedInventors: Julien Grassot, Cendrine Grangeon, Jordan Dubow
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Patent number: 11331287Abstract: An orally deliverable dosage system comprises (a) iron in a form of one or more physiologically acceptable iron grades, compounds and/or complexes; and (b) an agent to mitigate one or more gastrointestinal adverse effects of unabsorbed iron, said agent comprising one or both of a zinc component and a chelator component, said zinc component if present comprising one or more physiologically acceptable zinc compounds and/or complexes, and said chelator component if present comprising an ion-chelating compound formulated for release distal to the primary site of iron absorption in the duodenum.Type: GrantFiled: May 28, 2014Date of Patent: May 17, 2022Assignee: Balchem CorporationInventor: Jonathan David Bortz
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Patent number: 11208247Abstract: Melatonin tablets with a high concentration of citric acid are packaged in a blister package that enhances storage stability. Such a packaging material includes a blister film forming a cavity holding the tablet therein. The blister film includes a polyvinyl chloride (PVC) film having a thickness of 180 ?m to 270 ?m coated with a polyvinylidene chloride (PVDC) coating having a coating weight of 110 g/m2 to 130 g/m2. An aluminum foil lid closes the cavity and encapsulates the tablet within the blister film and lid. The lid has a thickness of 20 ?m to 30 ?m.Type: GrantFiled: July 26, 2018Date of Patent: December 28, 2021Assignee: Société des Produits Nestlé S.A.Inventors: Syed M. Shah, Daniel Hassan, Fred Hassan
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Patent number: 11166917Abstract: The present invention relates to a novel directly compressible matrix for the production of tablets which disintegrate rapidly in the presence of moisture, in particular in the mouth.Type: GrantFiled: May 25, 2009Date of Patent: November 9, 2021Assignee: Merck Patent GmbHInventors: Daniela Kleinwaechter, Guenter Moddelmog, Roberto Ognibene
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Patent number: 11116711Abstract: A solid cosmetic composition contains cationic surfactant, a polyhydric C2-C6 alcohol, C8-C30 alcohol or C8-C30 carboxylic acid or salt and a starch fraction, a modified starch or a starch derivative and is used for hair care.Type: GrantFiled: May 29, 2020Date of Patent: September 14, 2021Assignee: HENKEL IP & HOLDING GMBHInventors: Soeren Scheele, Manuela Mette, Petra Westphal, Thomas Schroeder
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Patent number: 10646533Abstract: An absorption enhancer for polyphenol containing at least one kind of extract selected from the group consisting of an extract from Kochia scoparia (L.) Schrad., an extract from Acacia concinna, an extract from Sanicula europaea, an extract from Bupleurum rotundifolium, and a seed extract from Camellia sinensis, as an active ingredient.Type: GrantFiled: November 11, 2016Date of Patent: May 12, 2020Assignee: Kao CorporationInventors: Shintaro Onishi, Shunsuke Ishii, Kojiro Hashizume
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Patent number: 10596120Abstract: The present invention relates to pharmaceutical compositions comprising fixed dose combinations of a DPP-4 inhibitor drug and/or a SGLT-2 inhibitor drug, and metformin XR, processes for the preparation thereof, and their use to treat certain diseases.Type: GrantFiled: February 27, 2018Date of Patent: March 24, 2020Assignee: Boehringer Ingelheim International GmbHInventors: Masanori Ito, Kenji Egusa, Roman Messerschmid, Peter Schneider
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Patent number: 10512656Abstract: The present invention relates to compositions and methods of treating lysosomal storage diseases and methods of using trehalose.Type: GrantFiled: April 21, 2017Date of Patent: December 24, 2019Assignee: Baylor College of MedicineInventor: Marco Sardiello
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Patent number: 10512609Abstract: The present invention relates to immediate release formulations of (R)-2-amino-3-phenylpropyl carbamate and methods of using the same to treat disorders.Type: GrantFiled: December 19, 2018Date of Patent: December 24, 2019Assignee: Jazz Pharmaceuticals Ireland LimitedInventors: Clark Patrick Allphin, Edwin Gerard Walsh
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Patent number: 10398654Abstract: The present invention relates to pharmaceutical compositions comprising fixed dose combinations of a DPP-4 inhibitor drug and/or a SGLT-2 inhibitor drug, and metformin XR, processes for the preparation thereof, and their use to treat certain diseases.Type: GrantFiled: February 27, 2018Date of Patent: September 3, 2019Assignee: Boehringer Ingelheim International GmbHInventors: Masanori Ito, Kenji Egusa, Roman Messerschmid, Peter Schneider
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Patent number: 10226417Abstract: Certain embodiments of the invention include medical materials and methods comprising a biodegradable hydrophilic hydrogel comprising dispersed lipophilic particles that comprise a therapeutic agent, wherein the lipophilic particles have a low water solubility in physiological saline at physiological temperature.Type: GrantFiled: September 16, 2011Date of Patent: March 12, 2019Inventors: Peter Jarrett, Rami El-Hayek, Amarpreet S. Sawhney, Sarah Guedez
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Patent number: 10195151Abstract: The present invention relates to immediate release formulations of (R)-2-amino-3-phenylpropyl carbamate and methods of using the same to treat disorders.Type: GrantFiled: September 5, 2017Date of Patent: February 5, 2019Assignee: Jazz Pharmaceuticals International III LimitedInventors: Clark Patrick Allphin, Edwin Gerard Walsh
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Patent number: 9956310Abstract: A tampon comprising an absorbent pledget and a time-lapse indicator associated therewith is provided. The time-lapse indicator includes a sensory material surrounded by, embedded in, covered by, or coated with a release-retarding material that protects the sensory material and prevents its release, until after a predetermined period of time has elapsed. The time-lapse indicator is located on or in the tampon or tampon removal string, or, optionally, the tampon packaging. After the time-lapse indicator is activated and a predetermined period of time has elapsed, the sensory material is released and alerts the user that it is time to change the tampon.Type: GrantFiled: July 18, 2013Date of Patent: May 1, 2018Inventor: Jeannette Martello
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Patent number: 9795567Abstract: The present invention provides a solid immediate release dosage form adapted for oral administration of GHB. The solid immediate release dosage form includes an immediate release formulation comprising a relatively high weight-percentage of GHB with a bioavailability similar to that of a liquid GHB dosage form.Type: GrantFiled: June 3, 2014Date of Patent: October 24, 2017Assignee: JAZZ PHARMACEUTICALS, INC.Inventors: Andrea Marie Rourke, Maura Patricia Murphy, James Frederick Pfeiffer, Clark Patrick Allphin, Alya Kahn McGinlay
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Patent number: 9376569Abstract: The present disclosure provides colorant compounds and methods of isolation of the colorant compounds derived from a reaction of genipin and an amine. The colorant compositions comprise purified compounds (e.g., a purified polymer or a purified dimer) obtained from multiple fractioning by chromatography of the reaction resulting material. The purified polymer or dimer can be used as a colorant by itself or in combination with another colorant for imparting color to a food, a drug, a cosmetic, a medical device, and textile products.Type: GrantFiled: May 22, 2014Date of Patent: June 28, 2016Assignee: ECOFLORA S.A.S.Inventors: Esteban Vargas Cano, Luis Fernando Echeverri Lopez, Juan Fernando Gil Romero, Edwin Andrés Correa Garcés, Sandra Patricia Zapata Porras
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Patent number: 9157060Abstract: A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.Type: GrantFiled: March 4, 2013Date of Patent: October 13, 2015Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Frances S. Ligler, André A. Adams, Michael Daniele
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Publication number: 20150118307Abstract: Embodiments relate to Rifaximin polymorphic, salt, and hydrate forms, methods of producing polymorphic forms and to their use in medicinal preparations and to therapeutic methods using them.Type: ApplicationFiled: May 27, 2014Publication date: April 30, 2015Applicant: SALIX PHARMACEUTICALS, LTDInventors: Stephan D. Parent, Lisa Lynn McQueen, Patricia Andres, Paul Schields, Yiduo Wu, Fei Ding, Jared Peters Smit
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Patent number: 9012521Abstract: An object of the present invention is to provide a gel containing pyrroloquinoline quinone that is capable of easily forming a gel near room temperature and is useful even in the food sector, and a method for producing the gel. According to the present invention, there is provided a gel containing pyrroloquinoline quinone that uses pyrroloquinoline quinone itself as a gelling agent and a method for producing the gel by adding a salt of pyrroloquinoline quinone to water and subsequently adjusting the temperature or the pH to reduce solubility.Type: GrantFiled: August 9, 2011Date of Patent: April 21, 2015Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Tsuyoshi Mikekado, Kazuto Ikemoto, Hajime Shimizu
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Patent number: 8975228Abstract: Disclosed are methods and compositions related to the use of boswellic acids (such as acetyl-11-keto-?-boswellic acid, 11-keto-?-boswellic acid, ?-boswellic acid, acetyl-?-boswellic acid, 9,11-dehydro-?-boswellic acid, acetyl-9,11-dehydro-?-boswellic acid, ?-boswellic acid, acetyl-?-boswellic acid, 11-dehydro-?-boswellic acid, acetyl-9,11-dehydro-?-boswellic acid, lupeolic acid, acetyl lupeolic acid, 12-ursene-2-diketone, incensole, incensole acetate, a derivative, in particular an ester thereof, a pharmaceutically acceptable salt thereof, a combination thereof, or a preparation containing one or more of these compounds) for the human medical or veterinary prophylaxis and/or treatment of: a) damage to and/or inflammation of the islets of Langerhans and/or b) damage to the B-cells of the islets of Langerhans.Type: GrantFiled: September 22, 2011Date of Patent: March 10, 2015Assignee: Fraunhofer-Gesellschaft zur Forderung der Angewandten Forschung E.V.Inventor: Hermann P. T. Ammon
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Patent number: 8962018Abstract: The invention relates to a solid formulation for the oral administration of olanzapine that comprises a core of anhydrous olanzapine Form I or a pharmaceutically acceptable salt thereof and, optionally, pharmaceutically acceptable excipients, said core being coated with a functional polymer that acts as filmogenic agent. The method for obtaining it comprises: i) providing anhydrous olanzapine Form I or a salt thereof and, optionally, pharmaceutically acceptable excipients in solid form; ii) providing a functional polymer that acts as filmogenic agent; iii) preparing a dispersion of said functional polymer in an aqueous medium,—and applying the dispersion obtained in step iii) onto the solid form of step i).Type: GrantFiled: December 19, 2006Date of Patent: February 24, 2015Assignee: Laboratorios Lesvi, S.L.Inventors: Ignacio Diez Martin, Carmen Ubeda Perez, Pablo Pablo Alba
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Patent number: 8920840Abstract: The present invention relates to an enteric tablet with improved bioavailability, which is rapidly disintegrated after reaching the intestine to allow dissolution of the active ingredient, and which characteristically reduces the amount of talc to be used and is free of an alkali component.Type: GrantFiled: April 28, 2011Date of Patent: December 30, 2014Assignee: Takeda Pharmaceutical Company LimitedInventors: Masafumi Misaki, Yuki Tsushima, Masahiro Niwa
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Patent number: 8900575Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans. For example, the invention provides methods and compositions for the delivery of one or more oxalate-reducing enzymes embedded in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions including, but not limited to, hyperoxaluria, absorptive hyperoxaluria, enteric hyperoxaluria, primary hyperoxaluria, idiopathic calcium oxalate kidney stone disease (urolithiasis), vulvodynia, oxalosis associated with end-stage renal disease, cardiac conductance disorders, inflammatory bowel disease, Crohn's disease, ulcerative colitis, and patients who have undergone gastrointestinal surgery and bariatric surgery (surgery for obesity), and/or who have undergone antibiotic treatment.Type: GrantFiled: December 15, 2006Date of Patent: December 2, 2014Assignee: Oxthera Intellectual Property ABInventors: Qingshan Li, Harmeet Sidhu
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Publication number: 20140335174Abstract: The present invention provides a dry-coated tablet comprising: an inner core containing, as active ingredients, (a) tegafur, (b) gimeracil, and (c) oteracil potassium; and an outer shell.Type: ApplicationFiled: May 24, 2012Publication date: November 13, 2014Applicant: TAIHO PHARMACEUTICAL CO., LTD.Inventors: Takumi Okamoto, Takashi Yoshizawa, Yoshito Ohnishi
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Publication number: 20140335180Abstract: The invention relates to a product for oral administration intended for a pet, comprising extracts of punica granatum (pomegranate). The invention is characterised in that the invention further comprises at least two additional antioxidant compounds chosen from:— soya isoflavone extracts;— L-carnitine; and— taurine.Type: ApplicationFiled: November 8, 2012Publication date: November 13, 2014Applicant: VIRBAC SAInventors: Patricia Monginoux, Hugues Gatto, Christian Karst, Ferdinand Rudolf Waldenberger
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Publication number: 20140322324Abstract: Composition for use in treating bacterial infections, comprising a concentrate or an extract of origanum in combination with at least one concentrate or extract of another plant.Type: ApplicationFiled: December 14, 2012Publication date: October 30, 2014Inventor: Georgios PANDALIS
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Patent number: 8846089Abstract: A method is provided for producing a sugar-coated preparation including a solid composition containing a pharmacologically active ingredient and a sugar coating layer. The method comprises a step of forming the sugar coating layer with a sugar coating composition containing one or more sugar-alcohols selected from the group consisting of mannitol and erythritol and a polyvinyl alcohol-based resin. The sugar-coated preparation includes a solid composition containing a pharmacologically active ingredient and a sugar coating layer, wherein the sugar coating layer is made of a sugar coating composition containing one or more sugar-alcohols selected from the group consisting of mannitol and erythritol and a polyvinyl alcohol-based resin.Type: GrantFiled: May 30, 2012Date of Patent: September 30, 2014Assignee: Wakunaga Pharmaceutical Co., Ltd.Inventors: Yukoh Sakata, Masaharu Higuchi
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Patent number: 8846087Abstract: The present invention relates to an enteric coating formulation, as well as methods for preparing and using said enteric coating formulation. In particular, the invention relates to an enteric coating formulation that is made up of foodeous approved materials.Type: GrantFiled: August 25, 2004Date of Patent: September 30, 2014Assignee: Sensient Colors LLCInventor: Vic Young
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Patent number: 8846088Abstract: A novel method for the preparation of a tablet comprising a calcium-containing compound, the method involves a melt granulation process by which a sugar alcohol is melted and embeds the calcium-containing compound so that a sufficient taste masking of the chalkiness is substantially achieved and an unpleasant mouth feel of the calcium-containing compound is substantially avoided, while at the same time obtaining a low tablet volume. The method of the invention is especially suitable for the manufacturing of tablets having a high load of a calcium-containing compound.Type: GrantFiled: February 2, 2006Date of Patent: September 30, 2014Assignee: Takeda Nycomed ASInventors: Poul Egon Bertelsen, Peder Mohr Olsen, Carsten Martini Nielsen, Magnus Wilhelm Tolleshaug
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Publication number: 20140255485Abstract: The present invention relates to collagen hydrolysate and the use thereof for treating and/or preventing cellulite.Type: ApplicationFiled: May 20, 2014Publication date: September 11, 2014Applicant: GELITA AGInventors: Hans-Ulrich FRECH, Steffen OESSER, Stephan HAUSMANNS
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Publication number: 20140248351Abstract: The present invention relates to a granulate and a pharmaceutical composition comprising fesoterodine or a salt or a solvate thereof and stabilizer, in particular to a pharmaceutical composition comprising fesoterodine or a salt or a solvate thereof and sucrose, polyethylene glycol, cyclodextrin, and combinations thereof and to a process for its preparation. The granulate and the pharmaceutical composition are particularly useful as a medicament, especially for the treatment of urinary incontinence. The present invention relates to use of sucrose, polyethylene glycol, cyclodextrin, and combinations thereof for stabilizing fesoterodine or a salt or a solvate thereof in a pharmaceutical composition.Type: ApplicationFiled: April 10, 2012Publication date: September 4, 2014Applicant: LEK PHARMACEUTICALS D.D.Inventors: Sara Cesar, Klemen Naversnik, Tijana Stanic-Ljubin
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Patent number: 8815290Abstract: The present invention relates to an improved gelatinous coated dosage form having two end regions coated with gelatinous materials and an exposed circumferential band. Openings are provided in at least the exposed band to reveal the core material. The invention also relates to methods for manufacturing such gelatinous coated dosage forms.Type: GrantFiled: December 16, 2010Date of Patent: August 26, 2014Assignee: McNeil-PPC, Inc.Inventors: Roger A. Rinker, Nicholas J. Casale, James H. Comly, Brenda Pollock, Atul Ayer, Johan Geerke, Martin Costello, Dennis Wieand, Kishor Parekh
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Patent number: 8796196Abstract: A process for producing anionic, nonionic, amphoteric or cationic derivatized polysaccharide products which demonstrate high clarity in surfactant-based compositions. The polysaccharide polymer is reacted for a sufficient time and at a sufficient temperature in the presence of water, caustic, and at least one surfactant. The polysaccharide polymer may optionally be reacted with an oxidizing agent, hydrolytic or proteolytic enzymes, molecular weight reducing agents and a cationizing agent and nonionic agent. The formed derivatized polysaccharide has a lower clarity in water than in an aqueous surfactant system. The derivatized polysaccharide product can be used in personal care and or household care products.Type: GrantFiled: February 22, 2011Date of Patent: August 5, 2014Assignee: Hercules IncorporatedInventors: Anita N. Chan, Louis Patrick Dziuk, Jr., Paquita Erazo-Majewicz, Jashawant J. Modi, M. Olaf Michelson
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Patent number: 8778398Abstract: The present invention provides a solid immediate release dosage form adapted for oral administration of GHB. The solid immediate release dosage form includes an immediate release formulation comprising a relatively high weight-percentage of GHB with a bioavailability similar to that of a liquid GHB dosage form.Type: GrantFiled: May 4, 2010Date of Patent: July 15, 2014Assignee: Jazz Pharmaceuticals, Inc.Inventors: Andrea Marie Rourke, Maura Patricia Murphy, James Frederick Pfeiffer, Clark Patrick Allphin, Alya Khan McGinlay
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Patent number: 8771735Abstract: The present invention provides a pharmaceutical composition, presented as a solid unit dosage form adapted for oral administration of sodium oxybate. The preferred unit dosage form is a tablet comprising a relatively high weight-percentage of sodium oxybate, in combination with a relatively small weight-percentage of total excipients. This permits the tablets to contain/deliver a pharmaceutically effective amount, e.g., about 0.5-1.5 g of sodium oxybate in each tablet with a delivery profile similar to that of the liquid form. The tablets are bioequivalent to the liquid form.Type: GrantFiled: November 4, 2008Date of Patent: July 8, 2014Assignee: Jazz Pharmaceuticals, Inc.Inventors: Andrea Rourke, Clark Allphin, Maura Murphy
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Patent number: 8765180Abstract: A white coloring composition comprising calcium carbonate as a white pigment. It may be used in the manufacture of food and pharmaceutical products.Type: GrantFiled: December 28, 2009Date of Patent: July 1, 2014Assignee: Chr. Hansen A/SInventor: Klaus Koehler
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Patent number: 8741051Abstract: Composition (C) for coating ingestible solid forms, comprising, per 100% of its mass—from 10% to 90% of a graft copolymer of polyvinyl alcohol and of polyethers (Pi), and—from 10% to 90% by mass of an auxiliary coating agent, characterized in that a non-zero mass proportion of said auxiliary agent is polydextrose. Processes for the preparation and use thereof.Type: GrantFiled: October 1, 2008Date of Patent: June 3, 2014Assignee: Société d'Exploitation de Produits pour les Industries Chimiques SEPPICInventors: Sandra Lefebvre, Gérard Trouve, Michel Malandain
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Publication number: 20140147501Abstract: Controlled release, discrete, solid particles which contain an encapsulated and/or embedded component such as a heat sensitive or readily oxidizable pharmaceutically, biologically, or nutritionally active component are continuously produced without substantial destruction of the matrix material or encapsulant. A release-rate controlling component is incorporated into the matrix to control the rate of release of the encapsulant from the particles. The additional component may be a hydrophobic component or a high water binding capacity component for extending the release time. The plasticizable matrix material, such as starch, is admixed with at least one plasticizer, such as water, and at least one release-rate controlling component under low shear mixing conditions to plasticize the plasticizable material without substantially destroying the at least one plasticizable material and to obtain a substantially homogeneous plasticized mass.Type: ApplicationFiled: January 29, 2014Publication date: May 29, 2014Applicant: GENERAL MILLS, INC.Inventor: Bernhard H. VAN LENGERICH
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Publication number: 20140147500Abstract: Pharmaceutical compositions comprising one or more digestive enzymes and one or more gastrointestinal modulators of acid are provided. The one or more digestive enzymes may be coated, e.g., with a lipid. Also disclosed are methods for their use and controlled delivery in treating individuals with neurological, behavioral, infectious, or genetic diseases or conditions susceptible to treatment with digestive enzymes.Type: ApplicationFiled: November 19, 2010Publication date: May 29, 2014Inventors: Joan M. Fallon, Matthew Heil, James F. Szigethy, James Fallon
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Publication number: 20140147502Abstract: The present invention relates to an antibacterial agent and a hydrolysate made of at least one extract that has been produced by extraction using ethanol/water from dried plant material of: a) at least one of the plants selected from the group consisting of: Verbena officinalis L., Sambucus nigra L., Primula veris L., Primula elatior (L.) Hill, and Gentiana lutea L.; and a mixture thereof; or b) a mixture of: Verbena officinalis L., Sambucus nigra L., Primula veris L., Gentiana lutea L., and Rumicis herba; and subsequent removal of the ethanol/water extraction agent, wherein the hydrolysate can be obtained from the extract via hydrolytic treatment using a mineral acid. The hydrolyzates according to the invention show a pronounced antibacterial effect against germs relevant to the skin, ears, nose, and throat and respiratory systems.Type: ApplicationFiled: January 31, 2014Publication date: May 29, 2014Applicant: Bionorica AGInventors: Guenther Bonn, Guenther Stecher, Michael A. Popp, Robert Mayer
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Patent number: 8722089Abstract: The present invention features a method of making a coated tablet by dipping a core comprising an active agent into a coating liquid and drying said dipped core to form a outer-coating on the core, wherein the coating liquid contains at least one a starch having an amylose content of at least about 50 percent by weight of said starch.Type: GrantFiled: February 17, 2009Date of Patent: May 13, 2014Assignee: McNeil-PPC, Inc.Inventor: Jen-Chi Chen
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Publication number: 20140127294Abstract: Provided is an oral solid preparation of a compound anti-tubercular drug, wherein the active ingredients are rifampicin, isoniazid, pyrazinamide and ethambutol hydrochloride. The compound oral solid preparation is a coated tablet with coated core or a coated three-layer tablet, wherein the two active ingredients rifampicin and isoniazid do not contact directly. The compound oral solid preparation not only improves the stability of the compound preparation, but also improves the bioavailability of rifampicin.Type: ApplicationFiled: April 10, 2012Publication date: May 8, 2014Applicant: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.Inventors: Maojian Gu, Qilan Zheng, Chao Xu, Ning Li, Guixian Chen, Lan Zheng, Min Wang, Lintao Jiang
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Patent number: 8715731Abstract: A process for reducing the intensity of the intrinsic bitter taste of a water soluble active which comprises dry mixing of said active with ?-cyclodextrin.Type: GrantFiled: March 21, 2007Date of Patent: May 6, 2014Assignee: ISP Investments Inc.Inventors: Rama Haldar, Dipan Ray, Deborah Tobia, Donald Koelmel, Sidney Etienne
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Publication number: 20140099368Abstract: The invention provides novel hydroxystilbene-containing dosage forms, processes for producing these dosage forms and the use thereof for the treatment of menopausal symptoms in women, juvenile oligomenorrhea and dysmenorrhea, primary and secondary amenorrhea or endometritis.Type: ApplicationFiled: July 24, 2013Publication date: April 10, 2014Inventors: Peter Heger, Reinhard Rettenberger, Carl-Friedrich Spaich
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Patent number: 8679534Abstract: Controlled release oral solid dosage form for the reduction of serum cholesterol levels in humans include a drug comprising an alkyl ester of hydroxy substituted naphthalenes (e.g., lovastatin) and a controlled release carrier, such that the dosage form provides a mean time to maximum plasma concentration (Tmax) of the drug which occurs at about 10 to about 32 hours after oral administration on a once-a-day basis to human patients. The dosage form provides a therapeutically effective reduction in serum cholesterol levels. Methods of reducing serum cholesterol levels in humans are also disclosed.Type: GrantFiled: February 16, 2006Date of Patent: March 25, 2014Assignee: Andrx Labs, LLCInventors: Chih-Ming Chen, Joseph Chou, David Wong
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Publication number: 20130295179Abstract: The present application relates to compositions for use in a method of treating and/or preventing mental and behavioral disorders and/or improving mental health and cognitive functions in a subject, comprising: a) Docosahexaenoic acid (DHA) and/or the pharmaceutically acceptable derivatives and/or precursors thereof; b) Eicosapentaenoic acid (EPA) and/or the pharmaceutically acceptable derivatives and/or precursors thereof; c) ?-linolenic acid (GLA) and/or the pharmaceutically acceptable derivatives and/or precursors thereof; and at least a psychostimulant compound selected among methylphenidate HCl, atomoxetine, amphetamine, gamma-hydroxybutyrate, dextroamphetamine, sibutramine, methylenedioxymethamphetamine, and/or an anxiolytic compound selected among fluoxatine, sertraline, paroxetine, fluoroxamine, citralopram, venlafaxine, bupropion, nefazodone, and mirtazapine.Type: ApplicationFiled: April 12, 2013Publication date: November 7, 2013Inventors: Christian TERREAUX, Eleonora HOMBERGER, Burkhard KRIWET, Eduardo BARRAGAN PEREZ