Matrices Patents (Class 424/484)
  • Patent number: 11459427
    Abstract: Provided are synthesis methods of polymerizing aniline or derivatives thereof. The production of polyaniline or polyaniline derivatives is controlled by the type of oxidant added in the reaction medium. The methods include the step of using a safe and environmentally friendly carbomethyl cellulose (CMC) or modified CMC as an oxidant in the polymerization reaction to produce polyaniline or aniline derivatives. Synthesis methods of producing O-CMC and O-CMC-S oxidants are also provided herein.
    Type: Grant
    Filed: October 7, 2021
    Date of Patent: October 4, 2022
    Assignee: KING ABDULAZIZ UNIVERSITY
    Inventors: Khalid A. Alamry, Ajahar Khan, Abdullah Mohamed Asiri
  • Patent number: 11459493
    Abstract: This invention relates to a curable composition comprising: I. Component (I) comprising at least one resin having at least one functional group selected from the group consisting of ?-ketoester and malonate functional groups, II. Component (II) comprising at least one curing agent having at least one aldehyde functional group, and III. Component (III) comprising at least one compound having amine functionality, salts thereof, or combinations thereof; IV. Component (IV) which is at least one additive comprising at least one adhesion promoter, at least one green strength enhancer, or combinations thereof, or wherein said at least one additive is both an adhesion promoter and a green strength enhancer.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: October 4, 2022
    Assignee: Eastman Chemical Company
    Inventors: Terri Roxanne Carvagno, Monika Karin Wiedmann Boggs, Shawn Marie Dougherty
  • Patent number: 11447738
    Abstract: The disclosure provides compositions comprising a disaccharide, a nutrient, and a buffer, which may be used for the preservation of bacteria, such as during lyophilization and/or extended storage. Provided herein are methods for preserving bacteria, involving adding bacteria to the compositions and subjecting the compositions to a lyophilization cycle. Also provided herein are methods for generating compositions that may be used, for example for the preservation of bacteria.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: September 20, 2022
    Assignee: Vedanta Biosciences, Inc.
    Inventors: Daniel E. Couto, Shilpa Reddy, Jil Ulrich, Scott Michonski
  • Patent number: 11434400
    Abstract: This invention relates to an assembly component comprising at least one substrate coated with at least one curable composition comprising: I. a first component (I) comprising a resin having at least one functional group selected from the group consisting of ?-ketoester and malonate functional groups, II. a second component (II) comprising at least one curing agent having at least one aldehyde functional group, and III. a third component (III) comprising at least one compound having amine functionality, salts thereof, or combinations thereof.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: September 6, 2022
    Assignee: Eastman Chemical Company
    Inventors: Shawn Marie Dougherty, Terri Roxanne Carvagno, Monika Karin Wiedmann Boggs, Christopher Harlan Burk, Nick Allen Collins, Thauming Kuo
  • Patent number: 11422468
    Abstract: An effervescent developer precursor for preparing a developing solution for developing a lithographic printing plate precursor including an effervescence generating compound.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: August 23, 2022
    Assignee: AGFA NV
    Inventors: Thomas Billiet, Sam Verbrugghe
  • Patent number: 11420986
    Abstract: Nitric oxide-releasing mesoporous silica nanoparticles (MSNs) were prepared using an aminosilane-template surfactant ion exchange reaction. Initially, bare silica particles were synthesized under basic conditions in the presence of cetyltrimethylammonium bromide (CTAB). These particles were functionalized with nitric oxide (NO) donor precursors via the addition of aminosilane directly to the particle sol, and a commensurate ion exchange reaction between the cationic aminosilanes and CTAB. N-diazeniumdiolate NO donors were formed at the secondary amines to yield NO-releasing silica MSNs. Tuning of the ion exchange-based MSN modification approach allowed for the preparation of monodisperse particles ranging from 30 to 1100 nm. Regardless of size, the MSNs stored appreciable levels of NO (0.4-1.5 ?mol/mg) with tunable NO-release durations (1-33 h) dependent on the aminosilane modification. The range of MSN sizes and NO release demonstrate the versatility of this strategy.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: August 23, 2022
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Mark H. Schoenfisch, Robert J. Soto
  • Patent number: 11406669
    Abstract: The present disclosure relates to stem cells which express high levels of Angeopoetin-1 (Ang1) and uses thereof in inhibiting M1-type macrophage production and treating inflammatory disease such as diabetes.
    Type: Grant
    Filed: March 24, 2020
    Date of Patent: August 9, 2022
    Assignees: MESOBLAST INTERNATIONAL SARL, OAKTREE FUND ADMINISTRATION, LLC
    Inventors: Silviu Itescu, Paul Simmons
  • Patent number: 11395842
    Abstract: A method for producing a purified cannabis extract includes providing a first extract with an organic hydrophilic solvent, at least one cannabinoid, and water at concentration W1 by weight, and at least one impurity at impurity to cannabinoid weight/weight ratio R1; adding water to the first extract to reach water concentration W2 by weight, whereby a solid matter and a second extract are formed; separating the solid matter from the second extract, whereby separated solid matter and separated second extract are formed. The separated second extract includes the organic hydrophilic solvent, the at least one cannabinoid, and water to cannabinoid weight/weight ratio R2.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: July 26, 2022
    Assignee: BUZZELET DEVELOPMENT AND TECHNOLOGIES LTD
    Inventors: Aharon M. Eyal, Dana Berneman Zeitouni
  • Patent number: 11389569
    Abstract: An injectable hydrogel composition that forms a porous gel rapidly after injection fro tissue engineering. The composition comprises a biodegradable, biocompatible, gelling polymer, that is optionally reverse-gelling; an Extra cellular matrix (ECM) material and a biocompatible porogen. Methods of making and using the composition are provided. A kit also is provided comprising the ingredients for making the hydrogel.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: July 19, 2022
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Stephen F. Badylak, Hong Jiang, Hideyoshi Sato, William R. Wagner, Yang Zhu
  • Patent number: 11389428
    Abstract: An oral melatonin pharmaceutical dosage form that contains a sustained release dose of melatonin includes melatonin and an acid dispersed in a hydrogel-forming polymer matrix that combine after ingestion to form an acidic hydrogel containing the melatonin.
    Type: Grant
    Filed: August 25, 2020
    Date of Patent: July 19, 2022
    Assignee: Société des Produits Nestlé S.A.
    Inventors: Syed M. Shah, Daniel Hassan
  • Patent number: 11389470
    Abstract: The present invention relates to a composition comprising at least one poloxamer compound for use in the treatment of a fistula in an individual.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: July 19, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ PARIS CITÉ, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS
    Inventors: Olivier Clement, Christophe Cellier, Claire Wilhelm, Florence Gazeau, Amanda Brun, Gabriel Rahmi
  • Patent number: 11389565
    Abstract: Described herein are molded dehydrated placental tissue compositions, and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the molded dehydrated placental tissue compositions are also described herein.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: July 19, 2022
    Assignee: MiMedx Group, Inc.
    Inventors: Thomas J. Koob, Guilhem Denoziere, Rebeccah J. C. Brown
  • Patent number: 11389794
    Abstract: A method for providing a solution of a substance in a microfluidic device includes providing a dispersion of a first medium and of a lyophilizate of the substance, the lyophilizate being insoluble in the first medium, and adding a second medium to the dispersion, the lyophilizate being soluble in the second medium. The method further includes dissolving the lyophilizate in the second medium such that the solution of the substance in the second medium is obtained, and separating the solution obtained by the dissolving of the lyophilizate from the first medium.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: July 19, 2022
    Assignee: Robert Bosch GmbH
    Inventor: Tino Frank
  • Patent number: 11344629
    Abstract: In one aspect, the disclosure provides mesoporous silica nanoparticles (MSNPs), monodisperse populations of MSNPs and related protocells which exhibit cell binding specificity. For example, MSNPs and protocells of the disclosure may be used to target specific delivery of therapeutic agents to CD19 or EGFR expressing cancer cells, or target specific delivery of therapeutic agents to other cell types. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: May 31, 2022
    Inventors: Charles Jeffrey Brinker, Kimberly Butler, Paul N. Durfee
  • Patent number: 11318096
    Abstract: The present disclosure provides methods and systems for forming stable droplets as part of an emulsion. The emulsion may be, for example, formed by bringing an aqueous phase in contact with an oil phase at a droplet generation junction of a droplet generator. Droplets of the present disclosure may be used for holding compositions for various uses.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: May 3, 2022
    Assignee: Ojai Energetics PBC
    Inventors: William Kleidon, Justin Kirkland
  • Patent number: 11305035
    Abstract: The disclosure provides implants containing a plurality of particles containing at least one population of viable cells adherent to and resident in soft tissue matrix or at least one viable population of cells caused to be in contact with the soft tissue matrix; methods of fabricating the implants; and use of the implants in tissue repair.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: April 19, 2022
    Assignee: Musculoskeletal Transplant Foundatiaon
    Inventors: Eric Semler, Alex Callahan, Joed Canales, Katrina Carroll, Anouska Dasgupta, Roman Shikanovich
  • Patent number: 11273164
    Abstract: Provides herein are compositions for the treatment of chronic vulval or perineal pain, and of symptoms or conditions associated therewith, comprising an estrogen, optionally estriol, and a tricyclic antidepressant, optionally amitriptyline, formulated for topical, transdermal or transmucosal administration. Also provided are methods for the production of said compositions and to uses thereof in the treatment of chronic vulval or perineal pain, and of symptoms or conditions associated therewith.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: March 15, 2022
    Assignee: TA Pharma Pty Limited
    Inventors: Thierry Vancaillie, Alan Hewitt
  • Patent number: 11266630
    Abstract: Disclosed is a solid dispersion and a preparation method therefor. The solid dispersion contains a glucokinase activator, an isotopic label thereof, or a medicinal salt thereof and a polymer support. Further disclosed is a solid dispersion composition containing the solid dispersion and an excipient. Also disclosed is an oral preparation of the glucokinase activator, containing the solid dispersion or the solid dispersion composition. Also disclosed is a tablet and a capsule of the glucokinase activator and a preparation method therefor. In addition, also disclosed is the uses of the solid dispersion, the solid dispersion composition and the oral preparations comprising the tablet and the capsule, which can be used for treating and/or preventing selected diseases or medical conditions and especially one or more diseases selected from type I diabetes mellitus, type II diabetes mellitus, impaired glucose tolerance, impaired fasting glucose and hyperglycemia.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: March 8, 2022
    Assignee: Hua Medicine (Shanghai) Ltd.
    Inventors: Li Chen, Yongguo Li, Gaosen Wang
  • Patent number: 11253504
    Abstract: Delivery systems and compositions comprised of a biodegradable polyorthoester polymer, an aprotic solvent, and a drug are described. The solvent is selected to modulate release of drug from the composition, where, in some embodiments, the solvent is rapidly released after administration and provides a corresponding rapid rate of drug release. Alternatively, in other embodiments, the solvent is slowly released from the composition after its administration, and provides a correspondingly slow rate of drug release.
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: February 22, 2022
    Assignee: Heron Therapeutics, Inc.
    Inventors: Thomas B. Ottoboni, Lee Ann Lynn Girotti
  • Patent number: 11253634
    Abstract: This disclosure relates to dermal treatment compositions, such as dermal fillers and tissue glues, and injectable compositions that incorporate one or more cationic steroidal antimicrobials (CSAs). The CSAs are incorporated into the dermal treatment compositions to provide effective antimicrobial, anti-inflammatory, analgesic, anti-swelling and/or tissue-healing properties. A treatment composition includes a component formed from a biologically compatible material suitable for injection into and/or application onto tissue at a treatment site. One or more CSA compounds are mixed with the biologically compatible material so that the one or more CSA compounds are incorporated within the composition, forming a reservoir of CSA compounds within the resulting bolus of the treatment composition after injection and/or application.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: February 22, 2022
    Assignee: BRIGHAM YOUNG UNIVERSITY
    Inventors: Paul B. Savage, Carl Genberg, Ronald Bracken
  • Patent number: 11202848
    Abstract: Compositions and methods for sealing tissue of a patient in a wet environment are disclosed.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: December 21, 2021
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Yves A. Delmotte, Jonathan Payssan
  • Patent number: 11202788
    Abstract: The present invention relates to an aqueous hydrogel composition for topical application to skin or a wound, comprising doxycycline with carboxy-methyl-cellulose, glycerol, citric acid, and at least one pH stabilizer, wherein the composition includes a suspension or dispersion of particles of doxycycline chelated with calcium, said particles have an average diameter less than or equal to about 100 microns, wherein the doxycycline chelated with calcium is present in an amount ranging from greater than about 0.1 weight % to about 3 weight %, wherein the composition includes less than 0.5 weight % 4-epidoxycycline. The present invention also describes methods for making a composition for topical applications as well as methods of treating skin or a wound with an aqueous hydrogel composition comprising doxycycline with carboxy-methyl-cellulose, glycerol, citric acid, and at least one pH stabilizer.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: December 21, 2021
    Assignee: Nanopharmaceutics, Inc.
    Inventor: James Talton
  • Patent number: 11198897
    Abstract: A method for rapid antibiotic susceptibility testing by tracking sub-micron scale motion of single bacterial cells including obtaining a biological sample from a subject including live bacteria. Different doses of antibiotic are added to a multi-well glass slide and adding portions of the biological sample to the wells. Bacterial cells are tethered onto the surface. The tethered bacterial cells are imaged and tracked. Bacterial sub-micron motion of tethered cells is measured at the different doses. A processor performs statistical analysis on a population of cells for each antibiotic dose to generate an antibiotic dose curve proportional to the motion changes, where the antibiotic dose curve plots data including a decrease in movement over time indicating a proportional effectiveness of an antibiotic applied to a well.
    Type: Grant
    Filed: October 16, 2020
    Date of Patent: December 14, 2021
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Nongjian Tao, Karan Syal
  • Patent number: 11197476
    Abstract: The compositions of the present invention comprise at least one medium polarity oil and at least one antibacterial agent, the combination of which produces a synergistic antibacterial effect against bacterial biofilms. Methods are disclosed for the reduction of bacteria in and/or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms.
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: December 14, 2021
    Assignee: SMITH & NEPHEW, INC.
    Inventors: Aleksa Jovanovic, Lei Shi, Eric Roche, Paul Renick
  • Patent number: 11191743
    Abstract: Various embodiments disclosed herein include methods of modulating the function of Zinc Activated Cation Channel (ZACN) in a subject comprising: administering to the subject a pharmaceutically effective dosage of ATP, a purinergic compound, red or blue dye, heparin or heparin analog, desipramine, reboxetine, and/or tomoxetine; and modulating the function of ZACN in the subject. Various embodiments disclosed herein also include methods of treating a disease in a subject comprising: administering to the subject a pharmaceutically effective dosage of a compound capable of modulating the function of the Zinc Activated Cation Channel (ZACN), and treating the disease.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: December 7, 2021
    Inventor: Yongchang Chang
  • Patent number: 11186489
    Abstract: Disclosed herein is zinc/amino acid functionalized silica, compositions comprising the same, and oral care methods and uses for such compositions.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: November 30, 2021
    Assignee: Colgate-Palmolive Company
    Inventors: Viktor Dubovoy, Tatiana Brinzari, Michael Stranick, Long Pan, Ravi Subramanyam
  • Patent number: 11178867
    Abstract: The present invention relates to anti-microbially active micro and nanoparticles, compositions comprising same, and use thereof for inhibiting bacterial growth and biofilm formation on surfaces or devices, e.g., dental surfaces or devices. The present invention further discloses methods of making such anti-microbially active micro or nanoparticles.
    Type: Grant
    Filed: February 26, 2017
    Date of Patent: November 23, 2021
    Assignee: NOBIO LTD.
    Inventors: Nathan Zaltsman, Ervin I. Weiss, Nurit Beyth
  • Patent number: 11160867
    Abstract: The present disclosure provides veterinary formulations comprising a therapeutically effective amount of an antiprotozoal compound and a polymer. The disclosure also provides methods of treating trichomoniasis in a bovine and methods of treating a Tritrichomonas foetus infection in a bovine utilizing the veterinary formulations.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: November 2, 2021
    Assignee: AUBURN UNIVERSITY
    Inventor: Sue H. Duran
  • Patent number: 11160866
    Abstract: The disclosure provides biomaterials including scaffolds that include blood products including blood fractions and products including platelets for administration to subjects in need thereof. More specifically, the scaffolds based on step growth polymers are enriched with blood extracts that contain platelet rich plasma (PRP) and/or extracts of platelets. Compositions comprising a biomaterial or precursor thereof and a blood extract are provided, as are methods of making and using the biopolymers or precursors thereof. Kits and articles of manufacture comprising the biopolymers or precursors thereof are also described.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: November 2, 2021
    Assignee: Mosaic Biosciences, Inc.
    Inventors: Peter D. Mariner, Martin Stanton, Alexei Kazantsev, Jeanne Callan
  • Patent number: 11141458
    Abstract: The present disclosure provides compositions comprising Ganoderma immunomodulatory protein or a recombinant thereof and a gel-forming agent. Also provided are methods for the treatment of chronic wounds, ulcers or sores, and methods using the compositions.
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: October 12, 2021
    Assignee: MYCOMAGIC BIOTECHNOLOGY CO., LTD.
    Inventors: Hsu-Yuan Fu, Yu-Che Cheng
  • Patent number: 11141508
    Abstract: Described are macro-capsules, barriers, and devices that can be used to prepare therapeutic cell implants, methods of encapsulating therapeutic cells, and methods of using the encapsulated cells in the treatment of disease.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: October 12, 2021
    Assignee: Seraxis, Inc.
    Inventor: William L Rust
  • Patent number: 11142723
    Abstract: The present invention relates to liquid fabric softener compositions comprising a quaternary ammonium ester softening active, cellulose fibers, and benefit agent capsules comprising a core and a shell encapsulating said core, wherein said shell comprises polyacrylate polymer, as well as methods of treating fabric and using same. Such liquid fabric softener compositions provide similar deposition of different types of fabric material.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: October 12, 2021
    Assignee: The Procter & Gamble Company
    Inventors: Susana Fernandez Prieto, Johan Smets, Pieter Jan Maria Saveyn, Laura Orlandini
  • Patent number: 11135174
    Abstract: Provided are methods for producing mesoporous nanoparticles that can, once loaded, retain small or large molecules (e.g., molecules having a molecular weight that is less or greater than about 900 Da) until release is desired, upon which time the mesoporous nanoparticles can release the loaded molecule in a controlled manner for a desired period of time, including an extended period of time. Also disclosed are methods for treating a subject comprising administering to the subject a mesoporous nanoparticle according to the present disclosure.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: October 5, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Paul Ducheyne, Sanjib Bhattacharyya
  • Patent number: 11130890
    Abstract: An adhesive composition that exhibits excellent adhesive performance such as curved surface adhesiveness to low-polarity adherends and constant load peeling properties in high-temperature environments, and also an adhesive sheet and a method for producing the same.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: September 28, 2021
    Assignees: TOYO INK SC HOLDINGS CO., LTD., TOYOCHEM CO., LTD.
    Inventors: Yoshitaka Tone, Toru Oya, Tetsuya Natsumoto, Hiroyuki Hayashi, Naoki Takeuchi, Yutaro Kato
  • Patent number: 11116728
    Abstract: A pharmaceutical composition comprises multiparticulates comprising a melt-congeal core and a solid amorphous dispersion layer of a poorly water soluble drug and polymer. The multiparticulates are suitable for improving bioavailability of poorly water soluble drugs. The melt-congeal cores facilitate application of the solid amorphous dispersion layer, and allow incorporation of additional optional components to the core so as to adjust the release of drug from the multiparticulate.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: September 14, 2021
    Assignee: Bend Research, Inc.
    Inventors: Dwayne Thomas Friesen, Leah E. Appel, Joshua Richard Shockey, Sanjay Konagurthu, Edward Dennis LaChapelle
  • Patent number: 11096963
    Abstract: Provided herein are compositions and kits including a pathogen-inactivated cryoprecipitate suitable for infusion into a subject at least 1 day after thawing. The methods are useful in the efficient preparation of cryoprecipitates with desirable characteristics, including pathogen-inactivated cryoprecipitates that are suitable for infusion into a subject at least 1 day after thawing.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: August 24, 2021
    Assignee: Cerus Corporation
    Inventors: Laurence Corash, Elan Weiner, Melody Holtan, Richard Benjamin
  • Patent number: 11083734
    Abstract: The present invention relates to an oral film consisting essentially of dexamethasone and hydroxypropyl methylcellulose, wherein the concentration of dexamethasone is 30% w/w or more and the concentration of hydroxypropyl methylcellulose is between 35 and 70% w/w based on total dry matter.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: August 10, 2021
    Assignees: ACUCORT AB, LTS LOHMANN THERAPIE-SYSTEME AG
    Inventor: Bengt Arvid Westrin
  • Patent number: 11072661
    Abstract: Disclosed are agents inhibiting the interaction between CFH and CD11b/18, as well as the use of such agents, in particular for treating inflammatory disorders, such as age-related macular degeneration.
    Type: Grant
    Filed: December 23, 2016
    Date of Patent: July 27, 2021
    Assignees: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
    Inventors: Florian Sennlaub, Bertrand Callippe, Xavier Guillonneau, José-Alain Sahel
  • Patent number: 11065195
    Abstract: A composition suitable for topical application comprising a continuous phase and at least one discontinuous phase, said composition comprising at least one polyaphron dispersion, at least one vitamin D or vitamin D analogue and at least one corticosteroid.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: July 20, 2021
    Assignee: MC2 Therapeutics Limited
    Inventors: Derek Wheeler, David F. Steele, Michelle Georgiou, Steen Sindet-Pedersen
  • Patent number: 11065262
    Abstract: Provided herein are compositions, systems, and methods for treating wounds with the combination of statins and cholesterol to help prevent and reduce scar formation.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: July 20, 2021
    Assignee: Northwestern University
    Inventors: Thomas A. Mustoe, Robert D. Galiano, Seok Jong Hong, Ping Xie, Shengxian Jia
  • Patent number: 11021409
    Abstract: Fertilizers with urease inhibitors and/or nitrification inhibitors are described. The fertilizer can include an extruded granule containing urea, a polymeric binder, and a nitrification inhibitor and/or an urease inhibitor.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: June 1, 2021
    Assignee: SABIC GLOBAL TECHNOLOGIES B.V.
    Inventors: Yoganand Gurumallappa, Ravi Hegde, Satish Burla, Rajamalleswaramma Koripelly, Samik Gupta
  • Patent number: 10994248
    Abstract: Disclosed is a hollow fiber membrane module including a case and a hollow fiber membrane built in the case, wherein the hollow fiber membrane contains a polysulfone-based polymer and a hydrophilic polymer, and satisfies the following (A) and (B), and an amount of an eluted substance contained in a liquid obtained by circulating ultrapure water heated at 37° C. through a passage of an inner surface side of the hollow fiber membrane for 4 hours at 200 mL/min is 1.0 mg/m2 or less: (A) an insoluble component accounts for less than 3% by mass of the total mass of the hollow fiber membrane when the hollow fiber membrane is dissolved in N,N-dimethylacetamide; and (B) a flexible layer exists on a surface of a functional layer in a wet state and the flexible layer has a thickness of 7 nm or more.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: May 4, 2021
    Assignee: TORAY INDUSTRIES
    Inventors: Akihiro Hayashi, Yoshiyuki Ueno
  • Patent number: 10982899
    Abstract: Botanical materials are dehydrated, ruptured and comminuted into particles by blades or whips in a fluidized bed. Particles separated from a drying gas are transferred to reduced pressure insulated vessels. Solvents dissolve components of the particles under precise temperature control. Solvents are recirculated and distilled to recover distillates. Distillates are refined by thermal and pressure changes to remove fats, waxes and contaminants and are fractionated to specific essential oils. The essential oils are tested, winterized, filtered, decarboxilated, polished, diluted and discharged into collection vessels. The collected essential oils are pumped through needles into sealed cartridges. The cartridges are tamper-proofed, printed and labeled with batch, botanical source, process, tracking and tracing information and codes.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: April 20, 2021
    Inventor: Paul Joseph Gelardi
  • Patent number: 10973767
    Abstract: The present disclosure provides a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: April 13, 2021
    Assignee: Triastek, Inc.
    Inventor: Xiaoling Li
  • Patent number: 10898477
    Abstract: The present disclosure describes economical processes to improve the bioavailability of nutraceuticals by formulations that induce micronization and sustained release. The inventive process can be used to increase the solubility and bioavailability of lipophilic and moderately water-soluble nutraceuticals by combining excipients that increase the solubility and induce sustained release of the active compounds. The inventive process also can be used to increase the residence time of highly water-soluble nutraceuticals that are metabolized and eliminated quickly from the body, consequently increasing the therapeutic potential. The disclosed formulations advantageously are freely flowing powders that can be used to formulate with other ingredients into tablets, capsules, or the like; or used as bulk powders.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: January 26, 2021
    Assignee: BIOACTIVES LLC
    Inventors: Doddabele L. Madhavi, Daniel I. Kagan
  • Patent number: 10888538
    Abstract: The present patent application relates to novel polyunsaturated fatty acid salt (PUFA salts) solid formulations.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: January 12, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventors: Elger Funda, Denis Hug, Odile Krainz, Sean McDonnell, Shakuntala Ramnarain, Casey Sumner, Qiong Tang
  • Patent number: 10882019
    Abstract: The present disclosure is directed to compositions including a microemulsion comprising lecithin, a polysorbate, an alkyl polyglycoside, and optionally a solvent. Uses of the microemulsions are also disclosed.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: January 5, 2021
    Assignee: ARCHER DANIELS MIDLAND COMPANY
    Inventor: Shireen S. Baseeth
  • Patent number: 10869835
    Abstract: The present invention provides compositions, methods for lyophilizing compounds and making pharmaceutical compositions, and kits providing solutions and lyophilized formulations of compounds. The compositions, methods, and kits are particularly useful in pharmaceutical applications involving therapeutic agents that have low solubility at low and medium pH values. Certain embodiments provide methods for lyophilizing compounds in liquid solutions, which include the steps of: a) preparing aqueous solutions of a compound of interest in the absence of buffer; b) adjusting the pH to high values of pH in order to increase the solubility of the compound of interest; and c) freeze-drying the solution to provide a lyophilized solid composition. Aqueous solutions including buffer are also disclosed. Lyophilized formulations, including micronized and non-micronized powders, are provided.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: December 22, 2020
    Assignee: Biogen Chesapeake LLC
    Inventor: Sven Martin Jacobson
  • Patent number: 10864302
    Abstract: The present invention provides a method for preparing an injectable thermosensitive hydrogel for preventing adhesion including mixing methyl cellulose, polyethylene glycol, oxidized cellulose nanofibers and carboxymethyl cellulose. The injectable thermosensitive hydrogel for preventing adhesion is a sol at a low temperature and induces rapid gelation upon in vivo implantation due to thermosensitivity. In addition, the hydrogel can be rapidly changed into physical hydrogel without separate additives or chemical reaction during in vivo condition. In addition, the injectable thermosensitive hydrogel for preventing adhesion exhibits excellent biodegradability and biocompatibility, has no cytotoxicity, inhibits in vitro migration of rat bone marrow mesenchymal stem cells (rBMSCs), and exhibits anti-adhesion efficacy in a rat model of sidewall defect-cecum abrasion in vivo, thus being useful as an effective anti-adhesive agent.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: December 15, 2020
    Assignees: SOONCHUNHYANG UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION, NATIONAL INSTITUTE OF FOREST SCIENCE
    Inventors: Byong Taek Lee, Sun-Young Lee, Tamanna Sultana, Celine Abueva
  • Patent number: RE48536
    Abstract: A resilient resorbable chemically crosslinked collagen sponge for promoting soft tissue volume augmentation in the oral region, comprising 60-96% (w/w) collagen and 4-40% (w/w) elastin, which shows by mercury intrusion porosimetry interconnected pores with a median pore diameter between 50 and 90 ?m and at least 80% porosity with a pore diameter more than 10 ?m, an onset temperature of 45 to 57° C. and a density in dry state from 50 to 65 mg/cm3. A process for preparing a resilient resorbable chemically crosslinked collagen sponge. A method of using a resilient resorbable chemically crosslinked collagen sponge as an implant in the oral cavity for soft tissue volume augmentation.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: April 27, 2021
    Assignee: Geistlich Pharma
    Inventors: Cornel Imhof, Lothar Schloesser, Niklaus Stiefel, Martin Wuest