Abstract: There is disclosed a composition useful for medicated treatment of hooves of live animals. The composition comprises a major portion of a carrier and hoof penetrant, a minor amount of a filler comprising chiefly polyolefin fibers, and an oil-in-water emulsifier to form a staple composition. The composition can include optional quantities of a medicinal compound. A specific example of the compound comprises approximately 12 weight percent of chopped fibers of a polyolefin such as polyethylene or polypropylene, about 69 percent of a carrier comprising pine tar, paraffin wax and coconut oil, and an oil-in-water emulsifier such as an aliphatic alcohol or alkyl glucose fatty acid ester. Preferably, the composition also includes a medicinal compound such as alcohol, iodine or a soluble iodide. The method comprises packing the hooves of live animals such as horses with the composition.

Abstract: An insecticidal composition in the form of a hydrated macrogel containing at least one species of entomopathogen and a hydrated water retentive compound which acts as a water-reservoir for the entomopathogen. Optionally, the macrogel contains attractants, in particular raffinose and gamma-irradiated, fungal-decayed wood.

Abstract: The invention relates to a wound secretion absorbing hydrogel of the following composition:a) 20 to 70%-wt of at least one multivalent alcoholb) 10 to 35%-wt of at least one natural thickener (biopolymer)c) 0.05 to 12%-wt of at least one uncross-linked copolymer of one or more vinylcarboxylic acids and their salts (synthetic polymer)d) 0.05 to 10%-wt of a cross-linking agente) 0 to 50%-wt of water or physiological salineas well as to the use of this hydrogel as wound dressing.

Abstract: The Process according to the invention comprises:(1) the preparation of a liquid phase consisting essentially of a solution of the substance in a solvent or in a mixture of solvents to which may be added one or more surfactants,(2) the preparation of a second liquid phase consisting essentially of a non-solvent of a mixture of non-solvents for the substance and to which may be added one or more surfactants, the non-solvent or the mixture of non-solvents for the substance being miscible in all proportions with the solvent or the mixture of solvents for the substance,(3) the addition of one of the liquid phases prepared in (1) or (2) to the other with moderate stirring so as to produce a colloidal suspension of nanoparticles of the substance and,(4) if desired, the removal of all or part of the solvent or the mixture of solvents for the substance and of the non-solvent or the mixture of non-solvents for the substance so as to produce a colloidal suspension of nanoparticles of the desired concentration or to pro

Abstract: Balanced pH, thermo-irreversible gels are ideal vehicles for drug injection into the body of a mammal.

Abstract: The process according to the invention comprises: (1) the preparation of a liquid phase consisting essentially of a solution of the substance in a solvent or in a mixture of solvents to which may be added one or more surfactants, (2) the preparation of a second liquid phase consisting essentially of a non-solvent or a mixture of non-solvents for the substance and to which may be added one or more surfactants, the non-solvent or the mixture of non-solvents for the substance being miscible in all proportions with the solvent or the mixture of solvents for the substance, (3) the addition of one of the liquid phases prepared in (1) or (2) to the other with moderate stirring so as to produce a colloidal suspension of nanoparticles of the substance, and (4) is desired, the removal of all or part of the solvent or the mixture of solvents for the substance and of the non-solvent or the mixture of non-solvents for the substance so as to produce a colloidal suspension of nanoparticles of the desired concentration or to

Abstract: An aqueous or pulverulent, water-dispersible pharmaceutical preparation which contains an emulsifier, a protective colloid and, in microdisperse form, an edible oil or fat, a sparingly water-soluble active compound being dissolved in the oil or fat, and a process for its preparation.

Abstract: A system for stabilizing fibroblast-derived growth factors, maintaining their bioactivity over a prolonged period of time and controllably releasing them for use is disclosed. The system uses growth factors bound to biocompatible substrates via heparin or heparin derived compounds to maintain the bioactivity of the growth factors. A growth factor bound to a heparin coated substrate can be used independently as a controlled release device, or can be incorporated into a reservoir or matrix type controlled release devices to further enhance the controlled release properties. The stabilized growth factors can be implanted into a patient, thereby providing a means for producing an in vivo controlled release of a growth factor to the patient.

Abstract: Preparation of an effervescent aqueous solution which has an emollient action on the cuticles of the nails, by dissolving the following anhydrous solid compounds substantially simultaneously in water: urea, pyrrolidonecarboxylic acid and an alkali metal and/or ammonium bicarbonate, and additional ingredients, the different compounds being introduced in the form of a mixture or of several separate mixtures prepared in advance. These mixtures are in pulverulent or tablet form.Composition for the preparation of the effervescent aqueous solution.Cosmetic treatment of the cuticle of the nails using the effervescent aqueous solution.

Abstract: A process for imparting enhanced antimicrobial properties to medical devices, and particularly surgical and examination gloves, and to such gloves produced by the process. The process involves partially forming the gloves by dipping glove molds into a latex composition, for example, and prior to curing or heating to final form, dipping the already coated forms into a second composition containing an antimicrobial agent, and thereafter curing or heat setting the finally produced glove prior to stripping from the form. Alternatively, the antimicrobial composition can be additionally or independently applied to a cured glove before stripping. The result is a glove which prevents, or decreases the potential of, cross-contamination between the glove users and patients because it will kill or reduce the susceptible microorganisms prior to or after penetration of the basic material forming the glove.

Abstract: The present invention relates to a transdermal therapeutical system for the administration of physostigmine to the skin via a cover layer which is impermeable to active substances, a pressure-sensitive adhesive reservoir layer, and optionally a removable protective layer, said reservoir layer consisting of 10-90% polymeric material selected from the groups consisting of block copolymers on the basis of styrene and 1,3-dienes, polyisobutylenes, polymers on the basis of acrylates and/or methacrylates and esters of hydrogenated colophonium, 0-30%-wt softeners on the basis of hydrocarbons and/or esters, and 0.1-20%-wt physostigmine.

Abstract: The oral administration to an animal of sulglycotide `(a sulfoglycopeptide)` together with methylcellulose, pectin or tragacanth gum protects the animal against gastric ulcer.

Abstract: An external adhesive preparation comprising a steroid for treatment of skin diseases in admixture with an adhesive gel base comprising as essential components a water-soluble high molecular weight compound, water and a water-retaining agent. The external adhesive preparation is useful for treatment of skin diseases by applying the preparation spread on a soft support directly to diseased parts on the skin, thereby administering the contained steroid to the skin.

Abstract: A controlled release preparation of an active material comprising a reaction product obtained by reacting (a) a copolymer consisting essentially of maleic anhydride and at least one polyalkylene glycol ether represented by formula (I): ##STR1## wherein B represents a residue of a compound having from 2 to 8 hydroxyl groups; R.sup.1 represents an alkenyl group having from 2 to 5 carbon atoms; AO represents an oxyalkylene group having from 2 to 18 carbon atoms or a combination thereof which may be linked together in blocks or at random; R.sup.2 represents a hydrocarbon group having from 1 to 24 carbon atoms; a represents a positive integer, b and c each represents 0 or a positive integer, and a+b+c=2 to 8; l.gtoreq.0, m.gtoreq.0, n.gtoreq.0, and e+m+n=1 to 1000; and (b) an active material. The preparation is soluble both in water and in an organic solvent and exhibits activity for a prolonged period of time.

Abstract: Cosmetic creams or lotions comprising emulsions of shark liver oil, squalane, and squalene along with numerous other ingredients with therapeutic and synergetic effects on the skin are disclosed.

Abstract: Bioadhesives microcapsules capable of sustained release comprise xanthan gum, locust bean gum, a bulking agent and an active agent. The microcapsules are particularly useful for delivering buffering agents to the oral cavity for anticaries purposes.

Abstract: Disclosed is a porous protein particle for delivering over a period of time an active ingredient impregnated therein, and methods of making and using the same. The protein particles have a median size less than about 50 microns. Active ingredient entrapped in the porous structure is gradually released from the protein particle.

Abstract: Pharmaceutical formulations are disclosed, adapted for preparing solid oral dosage forms (tablets, capsules, lozenges, etc.) having a regular and sustained release after administration. Said formulations comprise one or more active substances and a retarding base or matrix consisting of a polysaccharide of natural origin, alone or mixed with one or more natural or synthetic polymers which may be used to modify the release pattern so as to obtain a therapeutically effective formulation.

Abstract: The present invention relates to a wound covering comprising a sheet of biopolymeric material and a film of a polyurethane resin obtained by reacting a diisocyanate and a random copolymer of tetrahydrofuran and ethylene oxide to produce a urethane prepolymer, and extending the molecular chain of said prepolymer by using a chain extender, said random copolymer containing 20 to 80% by weight of the ethylene oxide unit in the molecular chain thereof and having a number-average molecular weight of 800 to 3000.The wound covering of the present invention is excellent in adhesion flexibility, durability, easy handling, preservation, sterile filtration, compatibility with cell, blood starching, water-vapor permeability. Therefore, it is quite suitable for practical use.

Abstract: The present invention pertains to biodegradable sustained-release composins capable of achieving the sustained release of a pharmaceutical or other agent. The compositions can be formed into implant devices which may be used to treat a wide variety of diseases and conditions. The implants are especially useful in treating diseases such as periodontal disease which require prolonged drug release.

Abstract: Disclosed is a porous protein particle for delivering over a period of time an active ingredient impregnated therein, and methods of making and using the same. The protein particles have a median size less than about 50 microns. Active ingredient entrapped in the porous structure is gradually released from the protein particle.

Abstract: The invention relates to sustained pulsewise release pharmaceutical preparation which comprices drug-containing polymeric material layers (layers A) and polymeric material layers containing the drug in question only in a slight amount or free of the drug (layers B) disposed alternatingly, with the whole surface extending in the direction perpendicular to the layer plane being coated with a polymeric material which is insoluble in water or scarcely soluble in water (polymeric material C).This pharmaceutical preparation of this invention is designed so that active ingredients which should desirably be released pulsewise can be released therefrom in a pulse-like and clinically significant manner and thereby the pharmacological effects of said active ingredients can be maintained for a prolonged period of time.

Abstract: The present invention relates to a process of stabilizing micellular particles such as vesicles and increasing the shelf life by suspending the particles in a polymeric gel matrix. The invention also relates to such particles suspended in the gel matrix with a protective gel surface thereabout which is capable of becoming fluid and converting the protective surface of an aqueous suspension.

Abstract: A dermal composition comprising a drug, a multipolymer of ethylene-vinyl acetate, an acrylic polymer, and optionally one or more monomers, a natural or synthetic rubber and a tackifying agent. The ratio of the multipolymer to the rubber is, respectively, about 1:1 to about 10:1 and more preferably, 1:1 to 5:1 and more preferably 3:1. The dermal composition can optionally contain a crosslinking agent, tackifiers, penetration enhancers and other ingredients known for use in adhesives for the transdermal delivery of drugs. The dermal compositions can be produced by a variety of methods known in the preparation of drug containing adhesive preparations including the homogenous mixing of the multipolymer, drug and optional crosslinking agent and additional ingredients in solution or suspension or emulsion followed by removal of excess solvent.

Abstract: Solid nasal inserts of calcitonin and other peptides have particularly interesting drug absorption profiles.

Abstract: Anti-smoking oral preparations are provided containing a silver compound as the anti-smoking agent and a sweetener in which the silver compound is present in amounts of from 0.1 mg. to 2.5 mg. and the ratio of sweetness intensity based on sucrose to silver compound content is from 100:1 to 2500:1.

Abstract: This invention relates to a biodegradable collagen matrix having a pore size and morphology which enhances the healing of a wound. It further relates to a process for preparing the matrix. One embodiment of the invention comprises a biodegradable matrix which comprises collagen, hyaluronic acid and fibronectin. Other embodiments include a process which comprises freeze drying a dispersion containing collagen, crosslinking the collagen via two crosslinking steps and freeze drying the crosslinked matrix.

Abstract: Drug delivery compositions yeild new and unexpected degrees of stabilization, solubilization and delivery of incorporated medicaments, drugs, or other physiologically-active compounds. The compositions enable administration of drugs and other medically useful compounds via a variety of routes. More particularly, a drug delivery system or composition including one or more monomeric or polymerized surface active agents allows for rapid dissolution and smooth liberation of any desired incorporated drug or combinations, and the method of preparing the drug composition. In one embodiment, the physiologically-active compound is encapsulated by a coacervate-derived film, and the finished product is suitable for transmucosal administration. Other formulations of this invention may be administered via inhalation, oral, parenteral and by transdermal and transmucosal routes.

Abstract: A preparation for the once-daily, percutaneous administration of nicotine comprises nicotine uniformly distributed in a solid, semi-solid or mucilaginous medium which can be placed in intimate contact with the skin, the solid, semi-solid or mucilaginous medium is formed by adding a given amount of nicotine to a solution of a solidifying or gel-forming agent or mixture thereon in a suitable solvent or mixture of solvents and mixing or heating the mixture thereby obtained so as to form the solid, semi-solid or mucilaginous medium.The preparation can be used in a method of treating withdrawal symptoms associated with smoking cessation and for combating the psychological dependence that occurs through frequency smoking.

Abstract: A pharmaceutical dosage form is provided which disintegrates rapidly in water having an open matrix network structure comprised of mannitol and a natural gum and which can be used particularly for oral administration to pediatric and geriatric patients.

Abstract: The combination of a hydrophilic polymer with sulglycotide in pharmaceutical compositions for orally use enhances the anti-ulcer activity of sulglycotide.

Abstract: A heterogeneous interpenetrating polymer network is provided for use in the controlled release of drugs. The network is a heterogeneous matrix that is formed from a hydrophilic component such as polyethylene oxide or poly(N,N'-dimethyl acrylamide-co-styrene) and a hydrophobic component such as styrene, an alkyl methacrylate, or polytetramethylene ether glycol. The relative amounts of the two components, or "domains", can be varied, as can the diffusivities and solubilities of the drug combinations to be loaded therein, to control and change as desired the timed release profile of incorporated drug. Prolonged pseudo-zero order release can be obtained where one domain acts as a diffusion barrier layer to the release of drug from the other domain.

Abstract: Pullulan forms an association complex with PEG in a hydrous system. The assocation complex, as well as its pullulan and PEG components, exerts a decreased solubility in water. The association reduces or even eliminates the excessively high water-solubility, threading and stickiness of pullulan so that this extends the uses of pullulan and PEG such as those in gradually disintegrable- and sustained release-shaped articles for consumer's products, toiletries, cosmetics, pharmaceuticals and feeds.

Abstract: A system for controlled release both in vivo and in vitro of entrapped substances, either at a constant rate over a period of time or in discrete pulses, is disclosed. Biologically active substances, such as drugs, hormones, enzymes, genetic material, antigens including viruses, vaccines, or inorganic material such as dyes and nutrients, are entrapped in liposomes which are protected from the biological environment by encapsulation within semi-permeable microcapsules or a permeable polymeric matrix. Release of the entrapped substance into the surrounding environment is governed by the permeability of both the liposome and surrounding matrix to the substance.

Abstract: A liquid coacervate composition and a method of introducing heme, hemoproteins and/or heme-hemoprotein complexes into the body. The liquid composition, comprising an oxygen-carrying molecule containing iron and a two-phase aqueous coacervate system, can be administered orally or intraveneously. The liquid composition is utilized to augment the oxygen transport capability of the body, to treat for several of the anemias and/or to act as an oxygen-carrying plasma volume extender.

Abstract: A base for mucosal and denture adhesive pastes, a process for the preparation thereof, and pastes having this base.A base for mucosal and denture adhesive pastes, pastes having this base, and a process for the preparation thereof, are described.

Abstract: A pharmaceutical which is for nasal administration and contains a high molecular weight active compound and a gel-forming agent and, where appropriate, auxiliaries is described. High molecular weight active compounds of this type are, in particular, immunogens or other pharmacologically effective substances. In addition, a process for the preparation of a pharmaceutical of this type and its use are described.

Abstract: The invention relates to a therapeutic system for peroral administration and having systemic action, which system is in the form of a coated and/or laminated monocompartment system for administering carbamazepine. The therapeutic system comprises(a) a wall made of a material which is permeable to water and impermeable to the components of the drug-containing core,(b) a core containing finely particulate carbamazepine as drug and, as auxiliaries, a protective colloid that inhibits the crystal growth of carbamazepine in the presence of water, a swellable hydrophilic polymer and, optionally, a water-soluble compound for inducing osmosis and/or further pharmaceutically acceptable excipients, and(c) a passageway through the wall (a) for delivering the core components to the environmental body fluid. The therapeutic system can be used as an anticonvulsive for the treatment of convulsive states, especially epileptic states.

Abstract: A sugarless ingestible gel confectionary delivery system which includes a pectin gel component, an algin gel component and a polymer network gel component in amounts sufficient to form a gel confectionery unit. The inventive gel confectionery unit has reduced intrinsic viscosity prior to gelation which permits the inclusion of an edible insoluble solid in an amount sufficient to strengthen the internal combination pectin-algin gel network and to bind internal moisture sufficiently to enhance mold removal capabilities. The delivery system also includes hydrogenated starch hydrolysates. The delivery system may also include a further active ingredient such as a drug, medicament, or nutritional supplement. The product and method of the present invention also includes a composition in which the gel delivery system can be molded directly in the receptacle which is used to dispense the confectionery unit to the consumer.

Abstract: A delivery system is disclosed for delivering an agent to a selected environment of use having a pH of greater than 3.5.

Abstract: The invention provides an immunizing agent or preparation e.g. a vaccine for parenteral administration comprising particles of coalesced and covalently interlinked physiologically compatible proteinaceous molecules and, entrapped in these particles, an immunogen adapted to be released by the gradual proteolysis of the particles and, when so released, being of sufficient size to elicit an immuno response to characteristic immunogenic determinants of the immunogen. The proteinaceous molecules are preferably homotypic for the animal to be immunized. Preferably, the particles or molecules carrying the immunogenic determinants are crosslinked to the proteinaceous molecules.

Abstract: A controlled, slow release, solid pharmaceutical preparation includes at least one active ingredient and a blend of sodium alginate and sodium-calcium alginate.

Abstract: Laundering compositions containing particulate olfactory polymers which provide for the controlled release of olfactory compositions such as perfumes, the particulate olfactory polymers comprising a water-soluble normally solid polymer, a water-insoluble normally solid polymer, and at least one olfactory composition which is in each polymer, one polymer being in the form of discrete entitles in a matrix of the other polymer, together with laundering articles such as packets containing such compositions; methods for laundering using such compositions; the particulate olfactory polymers; and methods for preparing the particulate olfactory polymers.

Abstract: A gel formation for oral administration having improved palatability comprising an effective hypocholesterolaemic amount of a uniform gelled dispersion of(a) between about 8 and about 20 percent by weight of a particulate, pharmaceutically acceptable, sparingly crosslinked non-digestible quaternary ammonium substituted polysytrene anion exchange resin having an average particle size below about 100 microns;(b) between about 4 and about 16 percent by weight of a pharmaceutically acceptable gelatin;(c) between about 0.015 and about 10 percent by weight of a natural or synthetic pharmaceutically acceptable sweetener;(d) between about 0.05 and about 2 percent by weight of a pharmaceutically acceptable organic acidulent;(e) between about 0.05 and about 5 percent by weight of one or more pharmaceutically acceptable flavoring or coloring agents or mixtures thereof; and(f) the remainder water.

Abstract: Anti-smoking oral preparations are provided containing a silver compound as the anti-smoking agent and a sweetener in which the silver compound is present in amounts of from 0.1 mg. to 2.5 mg. and the ratio of sweetness intensity based on sucrose to silver compound content is from 100:1 to 2500:1.

Abstract: The invention provides an ointment composition for treating skin irritations such as diaper rash and decubitus. The composition includes zinc oxide, boric acid, karaya gum, peruvian balsam, cod liver oil and an appropriate solvent and pharmaceutical carrier.

Abstract: Non-compressed sustained release tablets which will float on gastric fulid are described. The tablets comprise a hydrocolloid gelling agent, the selected therapeutic agent and water.

Abstract: The instant invention is directed to a drug delivery device for the controlled release of beneficial agents and drugs into an environment of use comprising:(A) a core composition comprising(a) a water insoluble, non-diffusible charged resin entity, and(b) a diffusible, water soluble ionizable therapeutically active ingredient carrying the same charge as said resin entity; and(B) a substantially imperforate water-insoluble wall surrounding said core composition, prepared from a semipermeable material substantially impermeable to the core composition and permeable to the passage of an external fluid in the environment of use, with said wall having a hole(s) for release of the therapeutic agent through the water insoluble wall.

Abstract: A dermal compositon comprising a drug, a multi-polymer of vinyl acetate, polyethylene and optionally one or more monomers, a natural or synthetic rubber and a tackifying agent. The ratio of the multipolymer to the rubber is, respectively, about 1:1 to about 10:1 and more preferably 1:1 to 5:1 and more preferably 3:1. The dermal composition can optionally contain a crosslinking agent, tackifiers, penetration enhancers and other ingredients known for use in adhesives for the transdermal delivery of drugs. The dermal compositions can be produced by a variety of methods known in the preparation of drug containing adhesive preparations including the homogenous mixing of the multi-polymer, drug and optional crosslinking agent and additional ingredients in aqueous solution followed by removal of excess water.

Abstract: Virtually any material may be encapsulated in a starch matrix by combining the material with a high temperature-stabilized dispersion of starch, optionally in the presence of salt. The temperature-stabilized starch dispersion acts as a protective colloid, encasing the material to be encapsulated. Upon subsequent rapid cooling of this mixture on a chilled surface the starch polymer chains collapse upon themselves, forming a firm sheet or the like and encapsulating the core material. The sheet can then be cut, chopped or sliced in the wet state, then dried and ground to yield particles.