Synthetic Polymer Patents (Class 424/486)
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Patent number: 9937104Abstract: The present invention provides dental bonding agents and dental bonding systems comprising the dental bonding agents. The dental bonding agents of the invention are characterized by having antibacterial properties, and in some aspects of the invention, remineralizing properties.Type: GrantFiled: January 6, 2017Date of Patent: April 10, 2018Assignee: UNIVERSITY OF MARYLAND, BALTIMOREInventors: Huakun Xu, Michael Weir
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Patent number: 9925137Abstract: A skin defense system and a skin rejuvenation and defense system. The skin rejuvenation and defense system includes a skin rejuvenation application and a skin defense application that work together synergistically to rejuvenate and defend the skin from environmental insults that can accelerate the aging process and deprive the skin of its vitality. The skin rejuvenation application invigorates, oxygenates, and detoxifies the skin. After the skin has been opened up and made receptive by the skin rejuvenation application, the skin defense application absorbs into the skin to deeply moisturize and revitalize the skin. In addition to moisturizers, emollients, and similar ingredients that improve health and appearance of the skin, the skin defense application includes ingredients that can reverse and protect the skin from damage caused by pollutants (e.g., pollutants up to 2.5 micrometers) and pre- and pro-biotics that promote the growth and development of beneficial skin flora.Type: GrantFiled: August 18, 2016Date of Patent: March 27, 2018Assignee: Maple Mountain Group, Inc.Inventors: Holly Stone Stout, Keith Alan Murphy
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Patent number: 9919006Abstract: The present invention is directed to compositions and methods of removing potassium or treating hyperkalemia by administering pharmaceutical compositions of cation exchange polymers with low crosslinking for improved potassium excretion and for beneficial physical properties to increase patient compliance.Type: GrantFiled: July 29, 2016Date of Patent: March 20, 2018Assignee: Ardelyx, Inc.Inventors: Dominique Charmot, James P. Davidson, Fangling Lin, Jeffrey W. Jacobs, Natalia Blinova, Eric Labonte, Ingrid Langsetmo, Robert C. Blanks
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Patent number: 9901545Abstract: A method of making an oral soluble film, containing at least one active agent, includes providing a well of a predetermined size; depositing a film forming composition in the well; depositing an active agent composition in the well, the active agent composition being different than the film forming composition, the film forming composition and the active agent composition forming an admixture in the well; and drying the admixture in the well. Alternatively, the method includes providing a well of a predetermined size; depositing a film forming composition including at least one active agent in the well, the film forming composition having a viscosity below 2000 centipoise; and drying the film forming composition in the well.Type: GrantFiled: April 13, 2017Date of Patent: February 27, 2018Inventors: Richard C. Fuisz, Joseph M. Fuisz
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Patent number: 9884016Abstract: The present disclosure provides ready-to-use, oil/water emulsion compositions with mean droplet size (intensity-average, nm) of 100-500 nm, where the oil phase comprises clopidogrel free base dispersed in pharmaceutical acceptable oil(s). The emulsion uses clopidogrel free base or premix of clopidogrel free base in oil(s) as the starting materials and may also contain one or more excipients such as surfactant and or co-surfactant, osmotic agent, pH adjustment agent, antioxidant, preservative, sweetener, and/or suspending agent, etc.Type: GrantFiled: September 29, 2016Date of Patent: February 6, 2018Inventor: Jingjun Huang
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Patent number: 9877922Abstract: Disclosed is a process of preparing sustained release microspheres, containing a biodegradable polymer as a carrier and a drug, using spray drying. The process comprises preparing a solution, suspension or emulsion containing a biodegradable polymer, a drug and a solvent; spray drying the solution, suspension or emulsion; and suspending spray-dried microspheres in an aqueous solution containing polyvinyl alcohol to remove the residual solvent and increase the hydrophilicity of the microsphere surface. The process enables the preparation of microspheres having high drug encapsulation efficiency, almost not having a toxicity problem due to the residual solvent, and having good syringeability. The microspheres prepared according to the present invention release an effective concentration of a drug in a sustained manner for a predetermined period when administered to the body, and are thus useful in the treatment of diseases.Type: GrantFiled: April 24, 2009Date of Patent: January 30, 2018Assignees: Peptron Co., Ltd., Daewoong Pharmaceutical Co., Ltd.Inventors: Hee-Yong Lee, Jung-Soo Kim, Eun-Ho Shin, Seong-Kyu Kim, Eun-Young Seol, Mi-Jin Baek, Mi-Young Baek, Yeon-Jin Chae, Ho-Il Choi, Juhan Lee
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Patent number: 9867848Abstract: The present invention is directed to compositions and methods of removing potassium or treating hyperkalemia by administering pharmaceutical compositions of cation exchange polymers with low crosslinking for improved potassium excretion and for beneficial physical properties to increase patient compliance.Type: GrantFiled: March 29, 2017Date of Patent: January 16, 2018Assignee: ARDELYX, INC.Inventors: Dominique Charmot, James P. Davidson, Fangling Lin, Jeffrey W. Jacobs, Natalia Blinova, Eric Labonte, Ingrid Langsetmo, Robert C. Blanks
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Patent number: 9849089Abstract: The present invention relates to hydrogel particles coated with lipid, which are made from dispersing hydrogel particles in an organic solvent in which lipids are dissolved, and to a method for manufacturing same. Unlike the existing method for manufacturing hydrogel core vesicles, the present invention can effectively manufacture same by using an emulsification method, without involving the steps of chemical treatment of the surface of hydrogels or dilution, thereby facilitating mass production and preventing the decrease of drug encapsulation efficiency.Type: GrantFiled: October 12, 2011Date of Patent: December 26, 2017Assignee: AMOREPACIFIC CORPORATIONInventors: Eun Jung An, Do Hoon Kim, Hyung Jun Lim, Jong Won Shim, Choon Bok Jeong, Lee Kyoung Kwon, Jun Oh Kim
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Patent number: 9850543Abstract: The invention provides methods of detecting cancer biomarkers, such as one or more SWI/SNF complex mutations, in order to determine a cancer subject's amenability to therapeutic treatment with a BRM inhibitor. Kits, methods of screening for candidate BRM inhibitors, and associated methods of treatment are also provided.Type: GrantFiled: March 12, 2014Date of Patent: December 26, 2017Assignee: Novartis AGInventors: Zainab Jagani, Gregory Hoffman, Frank Peter Stegmeier, Craig Stephen Mickanin
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Patent number: 9849125Abstract: Described herein are abuse deterrent oral pharmaceutical compositions, methods for making the same, and methods of treatment using such compositions. In particular, oral pharmaceutical compositions that mitigate the risk of overingestion of one or more active pharmaceutical ingredients are described.Type: GrantFiled: November 2, 2016Date of Patent: December 26, 2017Assignee: Banner Lifie Sciences LLCInventors: Chue Hue Yang, Tatyana Dyakonov, Nashwa El-Gendy, Jason M Vaughn, Justin R Hughey
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Patent number: 9790284Abstract: In certain aspects, the present invention provides compositions and methods for increasing thermogenic adipocytes (e.g., brown adipocytes or other UCP-1 expressing adipocytes) by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-myostatin antibodies, anti-GDF3 antibodies, anti-Noda1, anti-activin, and anti-GDF11 antibodies. A variety of metabolic and other disorders may be treated by causing an increase in thermogenic adipocytes.Type: GrantFiled: April 1, 2014Date of Patent: October 17, 2017Assignee: Acceleron Pharma Inc.Inventors: John Knopf, Jasbir Seehra, Ravindra Kumar
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Patent number: 9789201Abstract: The present invention relates to a complex that can be injected into the body to hone in on target cells to deliver molecules. In one embodiment, the invention provides a drug delivery system that includes components that self-assemble into one targeted conjugate. In another embodiment, the invention includes a targeted carrier protein and a nucleic acid sequence non-covalently linked to one or more drugs.Type: GrantFiled: July 10, 2015Date of Patent: October 17, 2017Assignee: CEDARS-SINAI MEDICAL CENTERInventor: Lali K. Medina-Kauwe
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Patent number: 9763873Abstract: Disclosed is a cosmetic or dermatological preparation which comprises one or more extracts of Saxifraga oppositifolia (purple saxifrage) and/or one or more extracts of Soldanella alpina (alpine snowbell). The use of these extracts to combat extrinsic and intrinsic skin aging is likewise described.Type: GrantFiled: August 7, 2014Date of Patent: September 19, 2017Assignee: LA PRAIRIE GROUP AGInventors: Daniel Stangl, Bernhard Dudler
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Patent number: 9765022Abstract: A compound of formula the following formula: (I). In this formula, moieties A, B, X, R1, R2, and R3 are defined herein. Also disclosed are a nanocomplex that is formed of such a compound and a pharmaceutical agent, and a nanocomplex that is formed of a protein and a bioreducible compound.Type: GrantFiled: February 28, 2014Date of Patent: September 19, 2017Assignee: Tufts UniversityInventors: Qiaobing Xu, Ming Wang
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Patent number: 9758465Abstract: Disclosed herein are drug release polymer compounds and compositions comprising prostacyclin compounds of Formula (I), and methods of preparing the same.Type: GrantFiled: April 29, 2014Date of Patent: September 12, 2017Assignee: United Therapeutics CorporationInventor: Peter Laing
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Patent number: 9757376Abstract: A composition of an antitussive, a decongestant, or an antihistamine to treat upper respiratory and oral pharyngeal congestion and related symptoms in a patient.Type: GrantFiled: October 6, 2016Date of Patent: September 12, 2017Assignee: GM Pharmaceuticals, Inc.Inventor: Odes W. Mitchell
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Patent number: 9724397Abstract: The present invention relates to a parenteral, sustained and controlled release, semisolid formulation comprising an end-capped oligomer and at least one active substance without any supplementary viscosity reducing agent or excipient.Type: GrantFiled: October 26, 2007Date of Patent: August 8, 2017Assignee: IPSEN PHARMA S.A.S.Inventors: Roland Cherif-Cheikh, Anne-Paula De Sousa Delgado, Frédéric Lacombe, Laurence Lachamp, Didier Bourissou
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Patent number: 9713793Abstract: A microporous membrane may be manufactured using a polymer binder and a filler material using a liquid pore forming agent having a surface free energy that is lower than that of the filler and higher than that of the polymer. The repulsion of the pore forming agent to the polymer may form the pores of the membrane, while the attraction of the polymer to the filler may encapsulate the filler into the structure of the membrane. The filler may be particles that are on the order of or smaller than the wall thickness of the microporous structure.Type: GrantFiled: March 13, 2012Date of Patent: July 25, 2017Assignee: SAMSUNG ELECTRONICS CO., LTDInventors: Kirby W. Beard, Ann M. Edwards
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Patent number: 9713642Abstract: The disclosure relates to, among other things, pharmaceutical compositions, such as solid oral dosage forms, comprising itraconazole, methods of making the compositions, and methods of using the same for treating disorders including, but not limited to, fungal infections.Type: GrantFiled: October 14, 2015Date of Patent: July 25, 2017Assignee: MAYNE PHARMA INTERNATIONAL PTY. LTD.Inventors: Stuart James Mudge, David Hayes, Stefan Lukas
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Patent number: 9694112Abstract: The present invention relates to systems for and corresponding methods of delivering a therapeutic agent to a vessel wall of a body lumen by providing a compound capable of being crosslinked after intraluminal release onto a vessel wall so that the therapeutic agent is temporarily retained at the site of delivery by the crosslinked compound.Type: GrantFiled: December 10, 2015Date of Patent: July 4, 2017Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC.Inventors: John Stankus, Mikael Trollsas, Syed Hossainy
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Patent number: 9675521Abstract: [Problem] There has been a requirement for a process for producing a pharmaceutical preparation that is obtained by encapsulating a uniform poorly water-soluble drug in a block copolymer, and dissolves immediately with an addition of water, and does not contain residues of organic solvents. [Solution] Provided is a method for producing a drug-block copolymer composite, the method comprising: mixing a poorly water-soluble drug and a block copolymer including a hydrophilic segment and a hydrophobic segment bonded together, in one or more non-aqueous solvents; optionally heating the mixture as necessary; and spray-drying the resulting mixture liquid.Type: GrantFiled: August 31, 2011Date of Patent: June 13, 2017Assignee: Nippon Kayaku Kabushiki KaishaInventor: Jun Motoyama
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Patent number: 9655970Abstract: A PLG copolymer material, termed a PLG(p) copolymer material, adapted for use in a controlled release formulation for a bioactive material is provided, wherein the formulation exhibits a reduced “initial burst” effect when introduced into the tissue of a patient in need thereof. A method of preparation of the PLG copolymer material is also provided, as are methods of use.Type: GrantFiled: December 19, 2016Date of Patent: May 23, 2017Assignee: Tolmar Therapeutics, Inc.Inventors: Eric Dadey, John Middleton, Richard L. Norton
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Patent number: 9655921Abstract: The present invention is directed to compositions and methods of removing potassium or treating hyperkalemia by administering pharmaceutical compositions of cation exchange polymers with low crosslinking for improved potassium excretion and for beneficial physical properties to increase patient compliance.Type: GrantFiled: December 22, 2015Date of Patent: May 23, 2017Assignee: Ardelyx, Inc.Inventors: Dominique Charmot, James P. Davidson, Fangling Lin, Jeffrey W. Jacobs, Natalia Blinova, Eric Labonte, Ingrid Langsetmo, Robert C. Blanks
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Patent number: 9655920Abstract: The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.Type: GrantFiled: February 24, 2011Date of Patent: May 23, 2017Assignee: Relypsa, Inc.Inventors: Eric Connor, Kalpesh Biyani, Scott Hecker, Inez Lees, Paul Mansky, YongQi Mu, Faleh Salaymeh, Hongmin Zhang, David Bergbreiter, Grace Huynh, Michael James Cope, Elizabeth Goka, Angela Lee, Deidre Madsen, Jun Shao, Xinnan Zhang
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Patent number: 9642931Abstract: A system for applying a treatment to a defect in one bone of two bones forming a joint that comprises a bladder for delivering a reduced pressure to the defect and for providing a positive pressure as bracing between the two bones of the joint is disclosed. A method for applying such treatment is also disclosed. A bladder for applying such treatment that comprises a reduced-pressure chamber and a bracing chamber is also disclosed.Type: GrantFiled: March 21, 2014Date of Patent: May 9, 2017Assignee: KCI Licensing, Inc.Inventors: Edward S. Griffey, Christopher Guy Coward, Colin John Hall
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Patent number: 9603975Abstract: The present disclosure pertains to compositions that comprise (a) a bioerodible polyester network formed by reaction between reactive species that comprise a polyol and a polycarboxylate, wherein at least one of the polyol and polycarboxylate has a functionality of three or more, and (b) a bioerodible thermoplastic polymer. The present disclosure further pertains to methods of using such compositions and to medical devices that comprise such compositions.Type: GrantFiled: December 16, 2015Date of Patent: March 28, 2017Assignee: Boston Scientific Scimed, Inc.Inventors: Gerald Fredrickson, Michael David Sinisi
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Patent number: 9592299Abstract: Fragmented polysaccharide based hydrogel compositions and methods of making and using the same are provided. The subject polysaccharide based hydrogel compositions are prepared by combining a polysaccharide component with a hydrophilic polymer and a cross-linking agent. Also provided are kits and systems for use in preparing the subject compositions.Type: GrantFiled: March 14, 2016Date of Patent: March 14, 2017Assignee: SpotLight Technology Partners LLCInventors: Scott Robert Sershen, Suresh Subraya Pai, Glen Gong
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Patent number: 9585387Abstract: PEHAM dendrimers of the formula: Specific PEHAM dendrimers are used in a formulation with an active agent for agricultural purposes. In particular, the PEHAM dendrimers may be used for increasing the efficacy of the active agent in various ways, such as by improving solubility of the active agent in the formulation, by improving adhesion and penetration of the active agent to plant surfaces, or by improving the water-fastness of the active agent to the plant or seed. The PEHAM dendrimers may also increase the efficacy of the active agent by increasing soil penetration of the active agent to reach the plant roots or under soil parts, by reducing soil adhesion of the active agent to reach the plant roots or under soil parts, or by reducing enzymatic degradation of the active agent by the plant or seed or microorganisms in the soil.Type: GrantFiled: February 16, 2015Date of Patent: March 7, 2017Assignee: STARPHARMA PTY LTDInventors: Ryan T. Hayes, David James Owen, Abhay Singh Chauhan, Veera Reddy Pulgam, Harsh Vardhan
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Patent number: 9585671Abstract: A hemostatic tablet preferably including potassium ferrate and a cation ion exchange resin pressure formed into a tablet for delivery to a bleeding wound. The tablet improves the rate of adhesion to a bleeding wound surface, and allows a significantly greater and more uniform pressure to be exerted by manual compression of the tablet on the wound site, as compared to that of a thin layer of scattered hemostatic powder. After the seal is formed from the interaction of blood or exudates with the immediate contacting surface of the tablet, the bulk of the unused tablet easily delaminates from the seal making clean up facile. If the unused portion of the tablet is not removed from the wound site, a reservoir of hemostatic dressing stops further bleeding and to provide antimicrobial protection and healing. The tablet may be applied to any surface orientation and take any shape and thickness possible.Type: GrantFiled: May 21, 2015Date of Patent: March 7, 2017Assignee: Biolife, L.L.C.Inventors: John Hen, Talmadge Kelly Keene, Mark Travi
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Patent number: 9579419Abstract: A hydrogel material for use in three-dimensional scaffold printing is disclosed. The material is formed from a first triblock polymer having a formula ABA and a second triblock polymer having a formula AmaBAma, wherein A is a first polymer, B is a second polymer, and Ama is a methacrylate of the first polymer. The material is thermosensitive and photocrosslinkable. A method of manufacturing the material is also disclosed.Type: GrantFiled: October 18, 2015Date of Patent: February 28, 2017Assignee: Drexel UniversityInventors: Gongyao Zhou, Christopher Geisler
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Patent number: 9579297Abstract: Since treatment effects of conventional external preparations were not satisfactory, it is aimed to provide a novel external preparation that is excellent in drug permeability to nail, capable of fully exhibiting effects of an antifungal drug, and effective for treatments of diseases such as nail mycosis and nail candidiasis, particularly, treatments for nail tinea. The external preparation of this invention is a pharmaceutical composition for nail characterized by containing an antifungal drug, alkylpyrrolidone or a derivative thereof, and a crosslinking hydrogel.Type: GrantFiled: December 26, 2006Date of Patent: February 28, 2017Assignee: TEIKOKU SEIYAKU CO., LTD.Inventors: Tomohiro Ishima, Mamoru Naruse, Hideo Kaneda, Kazuo Kanai, Takashi Sekine, Shinichi Ota, Tomonari Yoshimura
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Patent number: 9580519Abstract: The purpose of the present invention is to provide a method for producing a water absorbent resin in which a water absorbent resin having excellent properties can be obtained effectively.Type: GrantFiled: April 20, 2012Date of Patent: February 28, 2017Assignee: Nippon Shokubai Co., Ltd.Inventors: Kozo Nogi, Syuji Kanzaki, Kunihiko Ishizaki, Shinichi Fujino, Satoshi Matsumoto
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Patent number: 9566372Abstract: A polymeric composition includes a polymer matrix having a lipophilic discrete nitric oxide adduct and/or a polymeric nitric oxide adduct associated therewith, by covalent attachment to the polymer matrix and/or by dispersion within the polymer matrix, with the discrete nitric oxide adduct and/or the polymeric nitric oxide adduct being capable of releasing nitric oxide (NO). The polymeric composition further includes an ester capped poly(lactide-co-glycolide) (PLGA) additive to at least one of increase, prolong, and control NO release rates from the lipophilic discrete nitric oxide adduct and/or the polymeric nitric oxide adduct.Type: GrantFiled: September 25, 2013Date of Patent: February 14, 2017Assignee: The Regents of the University of MichiganInventors: Hitesh Handa, Mark E. Meyerhoff, Robert H. Bartlett, Elizabeth J. Brisbois, Lahdan Refahiyat
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Patent number: 9555026Abstract: The present invention relates to a solid dispersion comprising cilostazol, and methacrylic acid copolymer S and/or methacrylic acid copolymer L, which is characterized in that cilostazol is retained in an amorphous state in a gastrointestinal tract for a certain period after oral administration.Type: GrantFiled: February 5, 2014Date of Patent: January 31, 2017Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Junichi Kawasaki, Atsuya Nakamura, Naoki Kamada
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Patent number: 9555002Abstract: The invention relates to dosage forms which contain preparations of poorly water-soluble substances in a polymer matrix of polyether copolymers, said polyether copolymers being obtained by the radically initiated polymerization of a mixture from 30 to 80% by weight of N-vinyl lactam, 10 to 50% by weight of vinyl acetate and 10 to 50% by weight of a polyether, and at least one poorly water-soluble polymer, the poorly water-soluble substance being present in the polymer matrix as an amorphous substance.Type: GrantFiled: May 11, 2010Date of Patent: January 31, 2017Assignee: BASF SEInventors: Karl Kolter, Dejan Djuric, Stefan Fischer
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Patent number: 9555120Abstract: This invention provides a composition comprising: (i) a chitosan hydrogel comprising cross-linked chitosan and water; and (ii) a liquid dispersed in the hydrogel.Type: GrantFiled: April 15, 2011Date of Patent: January 31, 2017Assignee: VISCOGEL ABInventor: Mats Andersson
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Patent number: 9549907Abstract: Disclosed is an immediate release solution for oral administration of guaifenesin and at least one additional drug. In addition to water the solution comprises as solvents propylene glycol and glycerol in a concentration which significantly increases the bioavailability of guaifenesin in the human body.Type: GrantFiled: November 13, 2015Date of Patent: January 24, 2017Assignee: SOVEREIGN PHARMACEUTICALS, LLCInventor: Paul Hafey
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Patent number: 9549947Abstract: The present invention is directed to compositions and methods of removing potassium or treating hyperkalemia by administering pharmaceutical compositions of cation exchange polymers with low crosslinking for improved potassium excretion and for beneficial physical properties to increase patient compliance.Type: GrantFiled: February 24, 2016Date of Patent: January 24, 2017Assignee: Ardelyx, Inc.Inventors: Dominique Charmot, James P. Davidson, Fangling Lin, Jeffrey W. Jacobs, Natalia Blinova, Eric Labonte, Ingrid Langsetmo, Robert C. Blanks
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Patent number: 9545425Abstract: The present invention is directed to compositions and methods of removing potassium or treating hyperkalemia by administering pharmaceutical compositions of cation exchange polymers with low crosslinking for improved potassium excretion and for beneficial physical properties to increase patient compliance.Type: GrantFiled: February 24, 2016Date of Patent: January 17, 2017Assignee: Ardelyx, Inc.Inventors: Dominique Charmot, James P. Davidson, Fangling Lin, Jeffrey W. Jacobs, Natalia Blinova, Eric Labonte, Ingrid Langsetmo, Robert C. Blanks
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Patent number: 9539358Abstract: The present invention is directed to hemostatic material containing compacted ORC powder comprising particles having an average aspect ratio from about 1 to about 18, wherein said compacted ORC powder have preferably been processed in a compaction device, such as a ball milled ORC powder. The present invention further relates to methods of making the hemostatic material and a method of treating a wound by applying the hemostatic powder onto and/or into the wound of a patient.Type: GrantFiled: July 17, 2014Date of Patent: January 10, 2017Assignee: Ethicon, Inc.Inventors: Yi-Lan Wang, Guanghui Zhang
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Patent number: 9535062Abstract: Dual-functional nonfouling surfaces and materials, methods for making dual-functional nonfouling surfaces and materials, and devices that include dual-functional nonfouling surfaces and materials. The dual-functional surfaces are nonfouling surfaces that resist non-specific protein adsorption and cell adhesion. The dual-functional surfaces and materials include covalently coupled biomolecules (e.g., target binding partners) that impart specific biological activity thereto. The surfaces and materials are useful in medical diagnostics, biomaterials and bioprocessing, tissue engineering, and drug delivery.Type: GrantFiled: August 27, 2014Date of Patent: January 3, 2017Assignee: University of WashingtonInventors: Shaoyi Jiang, Zheng Zhang, Shengfu Chen, Hana Vaisocherova
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Patent number: 9533469Abstract: A self-healing product having a shape memory component and a healing component interpenetrating the shape memory component to form a fibrous microstructure. The healing component is selected so as to diffuse into a defect when the area of the product with the defect is subject to a treatment. The components may be selected so that applying heat at a temperature at or above a melting temperature (Tm) and/or a glass transition temperature (Tg) for one or both of the shape memory component and the healing component causes shape memory transition and diffusion by the healing component. The self-healing product can form a coating or material layer to protect a substrate while also providing the healing properties responsive to the treatment.Type: GrantFiled: December 22, 2009Date of Patent: January 3, 2017Assignee: Syracuse UniversityInventors: Patrick Mather, Xiaofan Luo
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Patent number: 9526794Abstract: The invention discloses injectable hydrogels which are in the form of crosslinked nano beads or particle in the size range 5 nm to 10 ?m, comprising PAMAM dendrimer with asymmetrical peripheral end groups such that one of the terminal groups is involved in formation of hydrogel and the other in involved in the conjugation of drugs or imaging agents and their methods of preparation. The said gel is formed by reaction of the PAMAM dendrimer with asymmetrical end groups with other polymer wherein the other polymer is selected from the group of linear, branched, hyperbranched or star shaped polymers with functionalized terminal groups. The PAMAM dendrimer with asymmetrical terminal groups consists of a Generation 2 and above PAMAM dendrimer with symmetrical end groups modified using the amino acids or their modified forms.Type: GrantFiled: March 31, 2011Date of Patent: December 27, 2016Assignees: Wayne State University, National Institutes of HealthInventors: Kannan Rangaramanujam, Sujatha Kannan, Roberto Romero, Raghavendra Navath, Anupa Menjoge
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Patent number: 9511146Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The vitamin-bearing subunits comprise a carbonate backbone portion and a side chain comprising a covalently bound form of a vitamin. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions can be suitable for depot injections. Synergistic enhancement of toxicity to microbes was observed with compositions comprising an antimicrobial cationic polymer and an antimicrobial compound.Type: GrantFiled: April 28, 2015Date of Patent: December 6, 2016Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: James L. Hedrick, Ashlynn L. Z. Lee, Victor W. L. Ng, Yi Yan Yang
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Patent number: 9498533Abstract: The present invention provides compositions and methods for the delivery of therapeutics to a cell or subject.Type: GrantFiled: April 4, 2012Date of Patent: November 22, 2016Assignee: Board of Regents of the University of NebraskaInventors: Tatiana K. Bronich, Alexander V. Kabanov, Jong Oh Kim
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Patent number: 9492444Abstract: The present disclosure relates to an oral, extended release, abuse deterrent pill containing at least one active pharmaceutical ingredient susceptible to abuse which is homogenously spread throughout a matrix used to deter abuse. The pill can be prepared using a hot melt extrusion process and a forming unit. The formed pill meets regulatory guidelines for extended release formulations and is abuse deterrent to parenteral administration due at least to particle size, viscosity, or purity limitations.Type: GrantFiled: December 17, 2014Date of Patent: November 15, 2016Assignee: Pharmaceutical Manufacturing Research Services, Inc.Inventors: Edwin R. Thompson, Eric R. Thompson, Nicholas R. Myslinski, Steven F. Kemeny
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Patent number: 9486404Abstract: Provided are methods of treating cardiac infarction by using an injectable material to influence cardiac structure and remodeling after infarction. Also provided are kits that comprise an injectable material to influence cardiac structure.Type: GrantFiled: March 27, 2012Date of Patent: November 8, 2016Assignee: The Trustees Of The University Of PennsylvaniaInventors: Jason A. Burdick, Robert C. Gorman, Joseph H. Gorman, III, Jamie L. Ifkovits
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Patent number: 9480250Abstract: The present invention relates to a method for the production of solid solutions of sparingly soluble pesticides, pulverulent products that are obtained by said method and their use for pesticide formulations.Type: GrantFiled: November 23, 2007Date of Patent: November 1, 2016Assignee: BASF SEInventors: Karl Kolter, Michael Schönherr, Hermann Ascherl, Cedric Dieleman, Torsten Knieriem, Sebastian Koltzenburg, Holger Türk
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Patent number: 9474911Abstract: The invention relates generally to intradermal, transdermal, and/or transmembrane delivery of biologically active substances in the epidermis and/or through the skin, sub-dermal tissues, blood vessels and cellular membranes without causing damage to the cellular surface, tissue or membrane. The biologically active substances may have a molecular weight no less than about 5.8 kDa to about 2,500 kDa, such as Hyaluronic Acid (HA). The biologically active substances may be deposited in a dermal patch containing a red algae polysaccharide-based matrix, wherein the red algae polysaccharide is an extract of Chondrus crispus at 2% by weight of the dermal patch. The invention provides systems and methods for enhanced intradermal, transdermal, and/or transmembrane delivery of such biologically active substances using pulsed incoherent light. The invention further provides a device for the application of the pulsed incoherent light to cellular surfaces and membranes using those compositions and methods.Type: GrantFiled: May 20, 2011Date of Patent: October 25, 2016Assignee: PhotoKinetix Holdings Inc.Inventors: Edward R. Kraft, Gabriela Kulp
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Patent number: 9463191Abstract: A composition of an antitussive, a decongestant, or an antihistamine to treat upper respiratory and oral pharyngeal congestion and related symptoms in a patient.Type: GrantFiled: June 8, 2015Date of Patent: October 11, 2016Assignee: GM Pharmaceuticals, Inc.Inventor: Odes W. Mitchell