Contains Proteins Or Derivative Or Polysaccharides Or Derivative Patents (Class 424/499)
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Patent number: 7790765Abstract: The present invention provides sodium 6-hydroxy-2,2-dimethyl-5-oxo-3,4,5,6-tetrahydro-2H-benzo(h)chromene-6-sulfonate, and its synthesis and uses in the treatment of cancer.Type: GrantFiled: April 30, 2008Date of Patent: September 7, 2010Assignee: ArQule, Inc.Inventors: Judit Bartis, Erika Volckova, Manish Tandon, Deirdre Lowe, Martin P. Redmon
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Publication number: 20100221356Abstract: A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum (Cmin) and maximum (Cmax) blood levels of about 0.5-2.5 ng/ml and about 2.0-6.0 ng/ml, respectively.Type: ApplicationFiled: May 12, 2010Publication date: September 2, 2010Applicant: SUPERNUS PHARMACEUTICALS, INC.Inventors: Argaw KIDANE, Henry H. Flanner, Padmanabh Bhatt, Arash Raoufinia
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Publication number: 20100221352Abstract: A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum (Cmin) and maximum (Cmax) blood levels of about 0.5-2.5 ng/ml and about 2.0-6.0 ng/ml, respectively.Type: ApplicationFiled: May 12, 2010Publication date: September 2, 2010Applicant: Supernus Pharmaceuticals, Inc.Inventors: Argaw KIDANE, Henry H. Flanner, Padmanabh Bhatt, Arash Raoufinia
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Publication number: 20100221354Abstract: A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum (Cmin) and maximum (Cmax) blood levels of about 0.5-2.5 ng/ml and about 2.0-6.0 ng/ml, respectively.Type: ApplicationFiled: May 12, 2010Publication date: September 2, 2010Applicant: Supernus Pharmaceuticals, Inc.Inventors: Argaw Kidane, Henry H. Flanner, Padmanabh Bhatt, Arash Raoufinia
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Publication number: 20100221355Abstract: A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum (Cmin) and maximum (Cmax) blood levels of about 0.5-2.5 ng/ml and about 2.0-6.0 ng/ml, respectively.Type: ApplicationFiled: May 12, 2010Publication date: September 2, 2010Applicant: SUPERNUS PHARMACEUTICALS, INC.Inventors: Argaw KIDANE, Henry H. FLANNER, Padmanabh BHATT, Arash RAOUFINIA
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Publication number: 20100221357Abstract: The present invention provides a particulate delivery system comprising an extracted yeast cell wall comprising beta-glucan, a payload molecule and a payload trapping molecule. The invention further provides methods of making and methods of using the particulate delivery system.Type: ApplicationFiled: May 17, 2010Publication date: September 2, 2010Applicant: UNIVERSITY OF MASSACHUSETTSInventor: Gary R. OSTROFF
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Publication number: 20100221353Abstract: A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum (Cmin) and maximum (Cmax) blood levels of about 0.5-2.5 ng/ml and about 2.0-6.0 ng/ml, respectively.Type: ApplicationFiled: May 12, 2010Publication date: September 2, 2010Applicant: Supernus Pharmaceuticals, Inc.Inventors: Argaw KIDANE, Henry H. Flanner, Padmanabh Bhatt, Arash Raoufinia
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Patent number: 7785629Abstract: The present invention relates to an adsorbate, comprising an adsorbent and bicalutamide adsorbed on said adsorbent, a process for preparing same, and a pharmaceutical composition thereof.Type: GrantFiled: June 21, 2005Date of Patent: August 31, 2010Assignee: Helm AGInventor: Klaus Glänzer
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Patent number: 7785853Abstract: The present invention relates to polypeptides having cellobiohydrolase I activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides.Type: GrantFiled: June 26, 2002Date of Patent: August 31, 2010Assignee: Novozymes A/SInventors: Lene Lange, Wenping Wu, Dominique Aubert, Sara Landvik, Kirk Matthew Schnorr, Ib Groth Clausen
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Patent number: 7785631Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.Type: GrantFiled: May 20, 2005Date of Patent: August 31, 2010Assignee: Quadrant Drug Delivery LimitedInventors: Bruce J. Roser, Jaap Kampinga, Camilo Colaco, Julian Blair
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Patent number: 7785625Abstract: A solid lipophilic microparticle having an average particle size ranging from 0.1 to 200 ?m, comprising a lipophilic substance, hyaluronic acid or an inorganic salt thereof and an active ingredient selected from the group consisting of a protein or peptide drug, retains the full activity of the active ingredient, and when formulated in the form of an oil dispersion or oil-in-water emulsion, it releases in an in vivo environment the active ingredient in a controlled manner over a long period.Type: GrantFiled: December 28, 2004Date of Patent: August 31, 2010Assignee: LG Life Sciences, LimitedInventors: Myung-Jin Kim, Sun-Jin Kim, Kyu-Chan Kwon, Joon Kim
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Publication number: 20100215760Abstract: The present invention provides solution to the problem involved in delivery of active molecules to nucleus. More particularly, the invention provides intrinsically fluorescent and inherently surface functionalized carbon nanospheres which are non-toxic. Also, these carbon nanospheres [CSP] were adsorbed with CTPB [CSP-CTPB] and the adsorbed CSP-CTPB are permeable to cells with nuclear targeting ability. In addition, the present invention provides a composition, a process to prepare the composition comprising CSP with adsorbed active/therapeutic molecules. Further, the instant invention provides a method for delivering active molecules inside a cell nucleus.Type: ApplicationFiled: September 30, 2008Publication date: August 26, 2010Applicant: JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCHInventors: Tapas Kumar Kundu, Eswaramoorthy Muthusamy, Ruthrotha Selvi Bharatha Vikru, Dinesh Jagadeesan
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Publication number: 20100215747Abstract: A pharmaceutical composition comprises nanoparticles comprising ionizable, poorly water soluble cellulosic polymers.Type: ApplicationFiled: June 30, 2008Publication date: August 26, 2010Inventors: Corey Jay Bloom, Marshall David Crew, Dwayne T. Friesen, Warren Kenyon Miller, Michael Mark Morgen, Daniel Tod Smithey
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Patent number: 7780991Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.Type: GrantFiled: May 20, 2005Date of Patent: August 24, 2010Assignee: Quadrant Drug Delivery LimitedInventors: Bruce J. Roser, Jaap Kampinga, Camilo Colaco, Julian Blair
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Publication number: 20100209353Abstract: The present invention relates to a protein conjugate having excellent tumor targeting capacity and a method for preparing the same, more precisely albumin-bile acid conjugate forming 30-500 nm nano-particles and forming self-aggregates in water system and a method for preparing the same. The albumin-bile acid conjugate of the present invention has excellent tumor targeting capacity and facilitates inclusion of a hydrophobic anticancer agent and can be combined with fore infrared ray fluorescent material. Therefore, this conjugate can be effectively used for the production of a novel nano-particle contrast agent or a nano-particle drug delivery system for the diagnosis and treatment of cancer.Type: ApplicationFiled: March 23, 2009Publication date: August 19, 2010Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Ick Chan KWON, Kwang Meyung KIM, Kuiwon CHOI
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Patent number: 7771751Abstract: The present invention provides compositions comprising a poorly water soluble pharmaceutical agent, a carrier protein, and an antimicrobial agent, wherein significant microbial growth is inhibited in the composition. The amount of the antimicrobial agent in the composition may be below the level that induces a toxicological effect or at a level where a potential side effect can be controlled or tolerated. Also provided are compositions comprising a poorly water soluble pharmaceutical agent, a carrier protein, a sugar, and optionally an antimicrobial agent. Methods of using the compositions are also provided.Type: GrantFiled: August 30, 2006Date of Patent: August 10, 2010Assignee: Abraxis Bioscience, LLCInventors: Neil P. Desai, Raj Selvaraj, Andrew Yang, Patrick Soon-Shiong
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Patent number: 7771755Abstract: Osteogenic proteins are delivered via an injectable solid rod or hardenable paste. The formulation comprises a calcium phosphate material, an osteogenic protein, and optional additives and active ingredients such as a bone resorption inhibitor. Methods of making injectable pharmaceutical compositions and methods of using the osteogenic compositions to treat bone defects are also disclosed.Type: GrantFiled: September 10, 2004Date of Patent: August 10, 2010Assignees: Wyeth, Etex CorporationInventors: Rebecca Li, Howard Seeherman, Hyun Kim
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Publication number: 20100189801Abstract: The invention provides a microsphere formulation for the sustained delivery of an aptamer, for example, an anti-Vascular Endothelial Growth Factor aptamer, to a preselected locus in a mammal, such as the eye. In addition, the invention provides methods for making such formulations, and methods of using such formulations to deliver an aptamer to a preselected locus in a mammal. In particular, the invention provides a method for delivering the aptamer to an eye for the treatment of an ocular disorder, for example, age-related macular degeneration.Type: ApplicationFiled: April 2, 2010Publication date: July 29, 2010Inventors: Karen G. Carrasquillo, Anthony P. Adamis, Joan W. Miller, Evangelos S. Gragoudas
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Patent number: 7763280Abstract: The invention relates to powdered preparations containing tiotropium for inhalation, processes for preparing them as well as their use in preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.Type: GrantFiled: November 20, 2003Date of Patent: July 27, 2010Assignee: Boehringer Ingelheim Pharma GmbH & Co. KGInventors: Mareke Hartig, Michael Trunk, Michael Walz
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Patent number: 7763278Abstract: The present invention is directed to nanoparticulate compositions comprising one or more polycosanols. The polycosanol particles of the composition have an effective average particle size of less than about 2000 nm. In another aspect of this invention, novel combinations of polycosanols and other cholesterol lowering agents are described and methods of using same are taught.Type: GrantFiled: June 10, 2003Date of Patent: July 27, 2010Assignee: Elan Pharma International Ltd.Inventors: Eugene R. Cooper, Laura Kline, Gary G. Liversidge, Niels P. Ryde
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Publication number: 20100183731Abstract: A pharmaceutical composition comprises nanoparticles comprising a poorly water soluble drug, a non-ionizable cellulosic polymer, and TPGS.Type: ApplicationFiled: May 26, 2008Publication date: July 22, 2010Inventor: Warren Kenyon Miller
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Publication number: 20100178337Abstract: The present invention relates to a composition comprising at least one active ingredient with low aqueous solubility, said active ingredient being present therein in a form noncovalently associated with nanoparticles formed by at least one POM polymer of formula (I), and in which said active ingredient is present in a proportion of at least 5 ?mol/g of POM. It is also directed towards the use of such nanoparticles, noncovalently associated with an active ingredient, with a view to increasing the aqueous solubilization of said active ingredient.Type: ApplicationFiled: December 18, 2009Publication date: July 15, 2010Applicant: Flamel TechnologiesInventors: Rémi MEYRUEIX, Rafael Jorda, Gauthier Pouliquen, You-Ping Chan, Olivier Breyne
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Publication number: 20100178354Abstract: It is intended to provide a remedy for diseases caused by macrophages with dysfunction or mediated by macrophages. Namely, a remedy which activates the phagocytic capacity of macrophages and thus is efficiently incorporated into the macrophages due to the vigorous phagocytosis. As a result, the macrophages with dysfunction are normalized, macrophages infected with a pathogen are exterminated or a pathogen in the infected macrophages is exterminated.Type: ApplicationFiled: March 22, 2010Publication date: July 15, 2010Applicant: TERADA, HiroshiInventors: Hiroshi Terada, Kimiko Makino, Gen-Ichiro Soma
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Publication number: 20100178331Abstract: Disclosed is a preparation for transnasal application, which has improved fluidability. Specifically disclosed is a preparation for transnasal application, which comprises at least a complex comprising: a fluidability-improving component comprising a first crystalline cellulose (A) having specified powder properties, tricalcium phosphate (B) having specified powder properties, and a second crystalline cellulose (C) having specified powder properties or a starch (D) having specified powder properties; and a physiologically active substance.Type: ApplicationFiled: December 25, 2007Publication date: July 15, 2010Inventors: Ryoichi Nagata, Shunji Haruta
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Publication number: 20100172829Abstract: Improved compositions for tissue augmentation are provided. These compositions comprise an amount of crosslinked material sufficient to provide a melt temperature (Tm) greater than 37 C, wherein microparticles can be substantially uniformly dispersed and maintained at ambient room temperature as well as body temperature. Said compositions also provide high shear moduli, sufficient to effectively deliver microparticles into dense tissue and narrow intersticial spaces without significant disruption to the homogeneous distribution of microparticles within the solution. The provided compositions can be stored and shipped at room temperature without significant detriment to the material composition. Additional embodiments include a system for delivery of tissue augmentation materials and methods of manufacture thereof.Type: ApplicationFiled: January 3, 2009Publication date: July 8, 2010Inventor: Russell J. Anderson
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Publication number: 20100173006Abstract: A method for ameliorating erectile dysfunction (ED) in a subject, by injecting a population of cells capable of increasing nitric oxide production in corporal tissue, and maintaining the cells in vivo to increase local tissue concentrations of nitric oxide, whereby intracavernous pressure can be improved upon stimulation.Type: ApplicationFiled: June 13, 2008Publication date: July 8, 2010Applicant: Wake Forest University Health SciencesInventors: James Yoo, Anthony Atala
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Publication number: 20100166875Abstract: The present invention relates to a colouring composition to be used in the manufacture of food and pharmaceutical products.Type: ApplicationFiled: July 1, 2008Publication date: July 1, 2010Applicant: Chr. Hansen A/SInventors: Klaus Koehler, Soeren Jan Jacobsen
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Publication number: 20100166872Abstract: The present invention relates to novel and improved compositions of anticancer drugs, preferably taxanes, such as paclitaxel and docetaxel, their derivatives or their analogues, methods of manufacturing these compositions and methods of fractionating the particles in particular size range and methods of treating cancer patients with these compositions, which provide reduced chemotherapy-induced side-effects especially reduced chemotherapy-induced-alopecia. The composition is such that there is substantially no free drug in the said composition.Type: ApplicationFiled: October 19, 2006Publication date: July 1, 2010Inventors: Amarjit Singh, Singh Sarabjit, Ajay K. Gupta, Mangesh M. Kulkarni
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Publication number: 20100166874Abstract: Microspheres are produced by contacting an aqueous solution of a protein or other macromolecule with an organic solvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals of defined dimensions.Type: ApplicationFiled: December 8, 2009Publication date: July 1, 2010Inventors: Michael P. Malakhov, Fang Fang
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Publication number: 20100166873Abstract: A eutectic-based self-nanoemulsified drug delivery system (SNEDDS) is formulated from polyoxyl 35 castor oil (Cremophor), medium chain mono- and diglycerides (capmul), essential oils, and a pharmacologically effective drug. The preferred pharmacologically effective drug is a poorly water soluble drug, such as ubiquinone (CoQ10). The SNEDDS can be further incorporated into a powder to produce a solid dosage form. The solid dosage form contains the SNEDDS, a copolymer of vinylpyrrolidone and vinyl acetate (Kollidon VA 64), maltodextrin, and microcrystalline cellulose (MCC).Type: ApplicationFiled: June 29, 2009Publication date: July 1, 2010Inventors: Mansoor A. Khan, Sami Nazzal
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Patent number: 7744851Abstract: The present invention is directed to a method for preparing an anhydrous 18F-radiolabeled fluorinating agent by a nucleophilic reaction of a hydrated 18F-radiolabeled fluoride ion source with an unsaturated carrier compound; treating the 18F-radiolabeled carrier compound to produce a non-aqueous mixture of the 18F-radiolabeled carrier compound in a solvent; and reacting the 18F-radiolabeled carrier compound with a nucleophilic composition in a nucleophilic reaction to produce an anhydrous 18F-radiolabeled fluorinating agent. The present invention is also directed to an anhydrous 18F-radiolabeled fluorinating agent comprising the formula [QnM]x+(18F?)x. Additionally, the present invention is directed to an 18F-radiolabeled fluorinated radiopharmaceutical or an 18F-radiolabeled fluorinated radiotracer prepared by reacting the anhydrous 18F-radiolabeled fluorinating agent with a drug intermediate.Type: GrantFiled: July 16, 2007Date of Patent: June 29, 2010Assignee: Board Of Regents Of The University Of NebraskaInventors: Stephen Gregory DiMagno, Haoran Sun
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Patent number: 7744925Abstract: The present invention encompasses a therapeutic composition in solid dose form that is suitable for pulmonary administration. The therapeutic composition may comprise therapeutic particles in a glassy state. The therapeutic composition preferably comprises a bioactive material such as insulin, and a sugar alcohol. The components are optionally in solid solution. The therapeutic composition can preferably remain in a glassy state when stored at elevated temperatures, and/or extended periods.Type: GrantFiled: May 20, 2005Date of Patent: June 29, 2010Assignee: Quadrant Drug Delivery LimitedInventors: Bruce J. Roser, Jaap Kampinga, Camilo Colaco, Julian Blair
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Patent number: 7744904Abstract: A stable composition including botulinum neurotoxin and a cyclodextrin and a method of preserving botulinum neurotoxin and for producing a botulinum neurotoxin composition with improved stability properties in an efficient and economically advantageous manner. The invention seeks to alleviate the problems associated with rapid degradation or denaturation of botulinum neurotoxin by providing a novel composition that exhibits improved stability properties. The botulinum neurotoxin is preferably stabilized by forming a cyclodextrin inclusion complex.Type: GrantFiled: September 21, 2006Date of Patent: June 29, 2010Assignee: B.B. Scientific L.L.C.Inventors: Bal Ram Singh, Andrew M. Ress
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Publication number: 20100159021Abstract: Provided herein are compositions and methods for treating cancer by increasing the pro-apototic actions of small molecule ligands of integrin RGD recognition sites such as polyphenols by administering such compounds in conjunction with anti-angiogenic thyroid hormone analogs such as tetrac or triac.Type: ApplicationFiled: December 22, 2009Publication date: June 24, 2010Inventors: Paul Davis, Faith B. Davis, Shaker A. Mousa, Hung-Yun Lin
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Patent number: 7740883Abstract: Methods are disclosed for preparing crosslinked core and core-shell nanoparticle polymers from chitosan. The final products of the present invention may be used as detergents and as additives for pharmaceutical composition and for drug delivery, and DNA carrier system. The nanoparticles made from biopolymers of the present invention may also be used in controlled release, superabsorbent materials and biomaterials like enzyme immobilization.Type: GrantFiled: March 28, 2005Date of Patent: June 22, 2010Assignee: University of DebrecenInventors: Janos Borbely, Magdolna Bodnar
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Patent number: 7740775Abstract: A process for preparing particles of a substance comprising contacting a first formulation including a first substance with a first solvent stream and a second solvent stream, thereby causing formation of particles of the first substance, wherein both the first and second solvent streams are in a non-supercritical state, and subjecting the resultant mixture to a separation process which causes separation of the first substance from the first and second solvent streams.Type: GrantFiled: November 7, 2002Date of Patent: June 22, 2010Assignee: Glaxo Group LimitedInventors: Mazin Nicola, Neale Gray
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Patent number: 7740884Abstract: The invention relates to the field of pharmaceutical formulations of a mixture of follicle stimulating hormone (FSH) and luteinising hormone (LH), and to methods of producing such formulations.Type: GrantFiled: June 16, 2004Date of Patent: June 22, 2010Assignee: Ares Trading S.A.Inventors: Fabrizio Samaritani, Piergiorgio Donati
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Publication number: 20100151038Abstract: A granular material which has a mean particle diameter of 150 to 800 micrometers; and an unsettled bulk density of 0.1 to 0.35 g/cm3 and/or a compactibility which results in a compact with a tensile strength of at least 1.7 MPa when the granular material is subjected to a compaction pressure of 266 MPa; and wherein the main component of the granular material is a cellulose derivative or an alkylene oxide homo- or copolymer or a blend thereof is useful for preparing dosage forms with a controlled release profile.Type: ApplicationFiled: February 28, 2008Publication date: June 17, 2010Inventors: Tim D . Cabelka, Akshay Bellare, Ka Chun A. Chan, Tina P. Dasbach, Kacee B. Ender, Karl V. Jacob, Robert E. Scheid, JR.
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Publication number: 20100151037Abstract: The present application relates to a method for preparing nanoparticles containing a poorly water-soluble pharmaceutically acceptable compound and compositions containing such nanoparticulates.Type: ApplicationFiled: August 6, 2009Publication date: June 17, 2010Inventors: Yivan Jiang, Zhiwei Jiang
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Publication number: 20100151036Abstract: A two-phase drug delivery medium comprising a discontinuous phase and a solid continuous phase, the discontinuous phase comprising a plurality of droplets, each of which comprises a fluid and at least one drug dissolved or suspended within the fluid, and the continuous phase surrounding and encapsulating the discontinuous phase.Type: ApplicationFiled: December 16, 2008Publication date: June 17, 2010Inventors: Bin Wu, Yanbin Huang
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Publication number: 20100143487Abstract: The present invention relates to biocompatible protein-based particles and their methods of preparation and use. More specifically the present invention relates protein-based particles including protein matrix, spread matrix and/or biocoacervate materials derived from one or more biocompatible purified proteins combined with one or more biocompatible solvents that are used to replace or repair tissue and/or bone in treatments for spinal disc(s), joint(s) (e.g. knee, hip, finger, ankle, elbow, shoulder . . . ) and organ(s) (e.g. bladder, lips, vagina, penis, urethra . . . ). In various embodiments of the present invention the protein-based particles may also include one or more pharmacologically active agents and/or one or more additives.Type: ApplicationFiled: December 26, 2008Publication date: June 10, 2010Applicant: GEL-DEL TECHNOLOGIES, INC.Inventor: David B. Masters
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Patent number: 7731991Abstract: The present invention relates to the non-food and non-pharmaceutical use of a powder anhydrous dextrose composition, characterized by the fact that the composition has: a) a particle size such that: at most 4% of its particles (expressed as a volume) have a size at most equal to 40 microns, and at most 8% of its particles (expressed as a volume) have a size at most equal to 100 microns, b) a hygroscopic index less than 1%, and c) an apparent density larger than 0.7 kg/l.Type: GrantFiled: October 28, 2005Date of Patent: June 8, 2010Assignee: Roquette FreresInventor: Jean-Jacques Caboche
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Patent number: 7731990Abstract: A powdery composition for nasal administration, where (1) the composition contains (i) a drug, (ii) a water-absorbing and gel-forming base material such as hydroxypropyl cellulose or hydroxypropylmethyl cellulose and (iii) a water-absorbing and water-insoluble base material such as crystalline cellulose or ?-cellulose, (2) wherein the amount of the water-absorbing and gel-forming base material is about 5-40 wt % based on the total of the water-absorbing and gel-forming base material and the water-absorbing and water-insoluble base material, and (3) wherein the drug is unevenly dispersed more on/in the water-absorbing and water-insoluble base material than on/in the water-absorbing and gel-forming base material.Type: GrantFiled: June 4, 2004Date of Patent: June 8, 2010Assignee: Teijin LimitedInventors: Masahiko Dohi, Yoshihisa Nishibe, Yuji Makino, Tako Fujii
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Publication number: 20100136127Abstract: The present invention provides a solid preparation containing compound (I) [compound (I) is as defined in the specification] or a salt thereof, and metformin hydrochloride, which is useful as a therapeutic drug for diabetes and the like, and superior in the preservation stability. A solid preparation having a first part and a second part: a first part: a part containing compound (I) or a salt thereof and substantially free of metformin hydrochloride a second part: a part containing metformin hydrochloride and substantially free of compound (I) and a salt thereof.Type: ApplicationFiled: July 16, 2008Publication date: June 3, 2010Inventors: Kazumichi Yamamoto, Hiroyoshi Koyama
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Publication number: 20100136128Abstract: An odor control fragrant additive comprises compacted pellets or granules infiltrated with fragrant oil. Cellulosic material, activated carbon and binder are mixed together and compacted to produce compacted pellets or granules. The cellulosic material preferably is peat moss, which swells up during absorption of fragrant oil and acts as fragrant oil storage. Fragrant oil is delivered to activated carbon that has large surface area, which evaporates the fragrance oil to release steady fragrance output. Thus, the activated carbon, which evaporates fragrance provides steady release of fragrance in the surrounding environment of fragrant compacted pellets or granules for a period of several months without overpowering the environment with excess fragrance. The fragrant compacted pellets or granules may be used to suppress malodor from trashcans or litter boxes and may provide stand-alone additions to drawers and cabinets, emitting pleasant fragrance.Type: ApplicationFiled: November 6, 2009Publication date: June 3, 2010Inventors: Marni Markell Hurwitz, Ernest D. Buff
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Publication number: 20100136129Abstract: The invention relates to nanoparticles comprising a biodegradable polymer, a cyclodextrin or a derivative thereof, and a biologically active molecule. Said nanoparticles can associate large amounts of biologically active molecules, especially of a hydrophobic nature, and release the biologically active molecule providing sustained and constant plasma levels thereof when they are administered orally or through any other mucosa of the organism.Type: ApplicationFiled: April 18, 2008Publication date: June 3, 2010Applicant: INSTITUTO CIENTÍFICO Y TECNOLÓGICO DE NAVARRA, S.AInventors: Maite Agüeros Bazo, Hesham H.A. Salman, Juan Manuel Irache Garreta, Miguel Angel Campanero Martínez
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Patent number: 7727954Abstract: The present invention relates to novel drug depot implant designs for optimal delivery of therapeutic agents to subjects. The invention provides a method for alleviating pain associated with neuromuscular or skeletal injury or inflammation by targeted delivery of one or more therapeutic agents to inhibit the inflammatory response which ultimately causes acute or chronic pain. Controlled and directed delivery can be provided by drug depot implants, comprising therapeutic agents, specifically designed to deliver the therapeutic agent to the desired location by facilitating their implantation, minimizing their migration from the desired tissue location, and without disrupting normal joint and soft tissue movement.Type: GrantFiled: April 12, 2007Date of Patent: June 1, 2010Inventor: William F. McKay
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Publication number: 20100129447Abstract: A pharmaceutical composition comprises nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a poorly aqueous soluble non-ionizable polymer.Type: ApplicationFiled: April 23, 2008Publication date: May 27, 2010Inventors: Corey Jay Bloom, Marshall David Crew, Daniel Tod Smithey, Warren Kenyon Miller, Michael Mark Morgen
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Publication number: 20100129461Abstract: A coated proteinaceous material can be produced by contacting the proteinaceous material with de-oiled phospholipids or mixtures thereof containing less than 20% triglycerides. The coating has between 0.1 and 1.5% by weight of the total proteinaceous material, of de-oiled lecithin. The proteinaceous material is hydrophobic, especially amino acids having a hydrophobicity of higher than 1.0 kJ/mol. In particular, the amino acids are leucine, isoleucine, valine, phenylalanine, tryptophan and/or methionine. The coated amino acids can be incorporated into food product and medicaments.Type: ApplicationFiled: April 21, 2008Publication date: May 27, 2010Applicant: N.V. NUTRICIAInventors: Natalie Elizabeth Hotrum, Carla Angèle Paula Buijsse, Robert Johan Joseph Hageman, Adrianus Lambertus Bertholdus Van Helvoort
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Publication number: 20100129460Abstract: Compounds comprising condensed particles having diameters less than 1000 nm, wherein the particles comprise one or more double stranded ribonucleic acids (dsKNAs) and one or more peptides. The compounds, compositions and methods are useful for modulating gene expression by RNA Interference.Type: ApplicationFiled: October 13, 2006Publication date: May 27, 2010Applicant: Nastech Pharmaceutical Company Inc.Inventors: Roger C. Adami, Tianying Zhu, Kunyuan Cui, Michael E. Houston, JR., Lishan Chen, Yuching Chen