Abstract: Controlled release verapamil tablets are disclosed. The tablets include an excipient having a hydrophilic material, preferably containing a mixture of xanthan gum/locust bean gum, and an inert diluent.

Abstract: Palatable cholestyramine granules, tablets and method for preparation thereof are disclosed.

Abstract: An oral composition which is adapted to be dispersed in an aqueous carrier substantially immediately prior to administration comprises a multiplicity of particles comprising an active substance, the particles being combined with one or more gelling or swelling agents capable of forming a viscous medium around the particles in an aqueous carrier as well as being provided with a masking surface layer when dispersed in the aqueous carrier. This serves to mask uneven surfaces on the particles and prevent them from adhering to oral mucosa when the composition is ingested and thus makes it easier to administer large dosages of an active substance. The masking surface layer is preferably provided by an increased viscosity of the viscous medium in the immediate vicinity of the particles relative to the viscosity of the surrounding aqueous carrier. A ready-to-use composition is prepared by mixing the composition with an aqueous carrier substantially immediately prior to administration of the composition.

Abstract: A free-flowing directly compressible granulation useful as a slow release pharmaceutical excipient is disclosed. The excipient includes a hydrodrophilic matrix which includes heteropolysaccharide and a polysaccharide material capable of cross-linking the heteropolysaccharide, and an inert diluent.

Abstract: A slow release pharmaceutical excipient of an inert diluent and a hydrodrophilic material including xanthan gum and a galactomannan gum capable of cross-linking the xanthan gum in the presence of aqueous solutions.

Abstract: Preparation of an effervescent aqueous solution which has an emollient action on the cuticles of the nails, by dissolving the following anhydrous solid compounds substantially simultaneously in water: urea, pyrrolidonecarboxylic acid and an alkali metal and/or ammonium bicarbonate, and additional ingredients, the different compounds being introduced in the form of a mixture or of several separate mixtures prepared in advance. These mixtures are in pulverulent or tablet form.Composition for the preparation of the effervescent aqueous solution.Cosmetic treatment of the cuticle of the nails using the effervescent aqueous solution.

Abstract: An antifouling coating composition useful for coating fish netting, boat hulls, lumber, roof shingles and the like to prevent the growth of algae or fungi. The composition comprises a vinyl polymer or copolymer emulsion containing a dialkyldimethyl ammonium compound with or without an alkylbenzyldimethyl ammonium compound. The preparation of the composition must be done with care in order to prevent the added quaternary ammonium compound from destabilizing the emulsion polymer. The invention also relates to articles coated with the composition to prevent the formation of algae and fungi thereon.

Abstract: A shampoo composition contains surfactant together with a cationic derivative of guar gum and an insoluble non-volatile silicone present as emulsified particles having average particle size below 2.mu.m. The silicone is preferably incorporated as a pre-formed emulsion.

Abstract: The oral administration to an animal of sulglycotide `(a sulfoglycopeptide)` together with methylcellulose, pectin or tragacanth gum protects the animal against gastric ulcer.

Abstract: An ion exchange resin composition which is readily dispersible in water is provided. This resin composition comprises a granulated ion exchange resin, a pharmacologically active ingredient bound thereto with a sugar or sugar alcohol, and a sufficient amount of water, alcohol or aqueous alcohol to facilitate granulation. The invention further comprises a method for the preparation of such ion exchange resin composition.

Abstract: Slow release drug delviery granules comprising porous granules of a calcium phosphate compound having an atomic ratio of Ca to P of 1.3 to 1.8, a porosity of 0.1 to 70%, a specific surface area of 0.1 to 50 m.sup.2 /g and a pore size of 1 nm to 10 .mu.m, fired at a temperature of 200.degree. to 1400.degree. C., and a drug component impregnated in pores of the granules, and a process for producing the same. The drug delivery granules of the present invention have a controllable, prolonged effect of drug release and a good imaging property to an X-ray or ultrasonic wave, and therefore can be advantageously utilized in the field of chemotherapy.

Abstract: The invention concerns a process for making a toothpaste containing an abrasive agent and a binder consisting wholly or partly of guar gum or other plant gum. The plant gum is hydrated by a liquid hydration medium consisting of water and 0 to 33% by weight of the hydration medium of sorbitol. To hydrate the plant gum it is mixed with the hydration medium in the presence of sufficient of the abrasive agent to produce enough shear to give a smooth cream. Other conventional ingredients are then mixed in.

Abstract: The present invention pertains to spray dried spheroidal microcapsules under about 150 microns in diameter which comprise in percentages by weight of the microcapsule composition (a) sucralfate present in an amount from about 1% to about 70%, and (b) a polymer soluble in the gastric fluids present in an amount from about 30% to about 99%. In another embodiment, the invention is directed at a taste masking composition which comprises a therapeutically effective amount of a spray dried spheroidal microcapsule core under about 150 microns in diameter and a matrix over the core wherein the taste masking composition comprises (A) a microcapsule core comprising in percentages by weight of the core composition (a) sucralfate present in an amount from about 1% to about 70%, and (b) a polymer soluble in the gastric fluids present in an amount from about 30% to about 99%; and (B) a matrix over the core comprising in percentages by weight of the matrix composition (a) a bulking agent present in an amount up to about 99.

Abstract: The instant invention relates to guar flour formulations, to be ingested, wherein the formulations contain natural guar flour having a particle size diameter or 50 .mu.m to 1500 .mu.m and neither containing nor having been treated with any additive which substantially affects its form or consistency or which substantially delays or reduces the swelling ability of the flour.

Abstract: A free-flowing directly compressible granulation useful as a slow release pharmaceutical excipient is disclosed. The excipient includes a hydrodrophilic matrix which includes a heteropolysaccharide and a polysaccharide material capable of cross-linking the heteropolysaccharide, and an inert diluent.

Abstract: An antifouling coating composition useful for coating fish netting, boat hulls, lumber, roof shingles and the like to prevent the growth of algae or fungi. The composition comprises a vinyl polymer or copolymer emulsion containing a dialkyldimethyl ammonium compound with or without an alkylbenzyldimethyl ammonium compound. The preparation of the composition must be done with care in order to prevent the added quaternary ammonium compound from destabilizing the emulsition polymer. The invention also relates to articles coated with the composition to prevent the formation of algae or fungi thereon.

Abstract: An aqueous or pulverulent, water-dispersible pharmaceutical preparation which contains an emulsifier, a protective colloid and, in microdisperse form, an edible oil or fat, a sparingly water-soluble active compound being dissolved in the oil or fat, and a process for its preparation.

Abstract: An oral composition which is adapted to be dispersed in an aqueous carrier substantially immediately prior to administration comprises a multiplicity of particles comprising an active substance, the particles being combined with one or more gelling or swelling agents capable of forming a viscous medium around the particles in an aqueous carrier as well as being provided with a masking surface layer when dispersed in the aqueous carrier. This serves to mask uneven surfaces on the particles and prevent them from adhering to oral mucosa when the composition is ingested and thus makes it easier to administer large dosages of an active substance. The masking surface layer is preferably provided by an increased viscosity of the viscous medium in the immediate vicinity of the particles relative to the viscosity of the surrounding aqueous carrier. A ready-to-use composition is prepared by mixing the composition with an aqueous carrier substantially immediately prior to administration of the composition.

Abstract: Pullulan forms an association complex with PEG in a hydrous system. The assocation complex, as well as its pullulan and PEG components, exerts a decreased solubility in water. The association reduces or even eliminates the excessively high water-solubility, threading and stickiness of pullulan so that this extends the uses of pullulan and PEG such as those in gradually disintegrable- and sustained release-shaped articles for consumer's products, toiletries, cosmetics, pharmaceuticals and feeds.

Abstract: A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not lower than about 5000 centiposes and finally subjecting the resulting emulsion to in water drying gives prolonged release of water-soluble drug.

Abstract: A pharmaceutical composition in the form of a multiphase (especially a bilayered, optionally coated) tablet. The tablet has a narcotic analgesic phase containing a therapeutically effective quantity of a narcotic analgesic or an analgesically effective salt thereof (e.g. codeine phosphate) and a non-steroidal anti-inflammatory phase containing a therapeutically effective quantity of a non-steroidal anti-inflammatory carboxylic acid or an anti-inflammatory salt or ester thereof (e.g. ibuprofen). The narcotic analgesic phase is free from a non-steroidal anti-inflammatory carboxylic acid or salt or ester thereof, stearic acid and stearate salt, and the non-steroidal anti-inflammatory phase is free from a narcotic analgesic or salt thereof, stearic acid and a stearate salt. Further, both the narcotic analgesic phase and the non-steroidal anti-inflammatory phase contain a self-lubricating, compression aid, especially a self-lubricating, direct compression aid, such as microcrystalline cellulose.

Abstract: A controlled, slow release, solid pharmaceutical preparation includes at least one active ingredient and a blend of sodium alginate and sodium-calcium alginate.

Abstract: The invention is a microsphere composition of fat or wax or mixture thereof and a biologically active protein, peptide or polypeptide suitable for parenteral administration. The invention is also a slow release composition of fat or wax or mixture thereof and a biologically active protein, peptide or polypeptide suitable for parenteral administration. The invention also relates to methods for increasing and maintaining increased levels of growth hormone in the blood of treated animals for extended periods of time, increasing weight gains in animals, and increasing milk production of lactating animals by the administration of compositions of the invention.

Abstract: Pharmaceutical compositions comprising spherical granules including thereon or therein a 7- or 9-akylamino-6-deoxy-6-demethyltetracycline or an acid-addition salt thereof blended with at least one excipient are adapted to control the rate of drug release in the stomach and in the intenstine in order not to produce nausea or dizziness upon oral administration during antibacterial therapy.

Abstract: There is disclosed an improved complex coacervation process for microencapsulation of core ingredients that are partially soluble in the microcapsule walls wherein the core ingredient is first mixed with a coacervation adjacent prior to forming a first colloidal emulsion of core ingredient, and, after combining the first emulsion with a second colloidal solution and cooling to cause gelation, a water-soluble wax derivative is added. No pH adjustment or dilution is necessary, and very high yields of non-agglomerated microcapsules are obtained, both in terms of quantity of microcapsules and content of core ingredient. When deet is the core ingredient there is obtained a long-lasting mosquito repellent.

Abstract: Novel beta-1,3-glucan polysaccharide gels characterized by (a) coherent, uniform, non-particulate structure, and (b) substantially uniform pH throughout. The gels are prepared by dissolving a beta-1,3-glucan polysaccharide in an aqueous alkaline medium at a temperature of about 55.degree. C. or below and while maintaining the solution at a temperature of at least 50.degree. C., adjusting the pH to 10.5 or lower, followed by cooling below about 40.degree. C. or heating above 50.degree. C. The gels formed by cooling are reversible whereas the gels formed by heating are thermally irreversible. The gels are useful for supporting, separating, transforming or treating biological materials, as carriers for pharmaceuticals, as coatings for biological materials, in food products, and can be shaped to form disposable contact lenses.

Abstract: A pharmaceutical preparation containing ibuprofen is disclosed. In the preparation, the ibuprofen particles are enveloped by a coating of a hydro-colloid and fumaric acid. Preferably, the hydro-colloid comprises xanthan gum and/or maltodextrin. This preparation reduces the tendency of ibuprofen to irritate the esophagus and the gastrointestinal tract when taken orally. An effervescent mixture of the ibuprofen containing preparation can be prepared by incorporating citric acid and calcium carbonate into the mixture. A process for the manufacture of the ibuprofen containing preparation is also disclosed. In this process, ibuprofen particles are coated with the hydro-colloid and fumaric acid under vacuum conditions in a vacuum mixing machine and the resulting preparation is thereafter vacuum-dried.

Abstract: A particulate coprocessed microcrystalline cellulose and calcium carbonate composition having the respective components present in a weight ratio of from about 75:25 to 35:65. The composition is useful as a pharmaceutical excipient.The coprocessed composition is prepared by forming a well-dispersed aqueous slurry of microcrystalline cellulose and calcium carbonate and then drying the slurry, preferably by spray drying, to yield a particulate product.