Abstract: A method for the treatment and prevention of dental caries and periodontal diseases using bacteriophages and phage-encoded anti-bacterial enzymes to inhibit establishment of bacteria in the oral cavity is provided. Also provided are methods for studying the cell wall of an oral bacterium, a method for preventing spoilage of perishable items and a method for removing dextrans from surfaces utilized in sugar manufacture. Purified enzymes and the isolated DNA fragments encoding them are also provided.

Abstract: Systems for delivering cosmetic and therapeutic actives to the oral cavity employ a strip comprising a first layer of material, a second layer comprising polybutene with a molecular weight of about 300 to about 3000, and a cosmetic or therapeutic active included within the second layer. Therapeutic and cosmetic actives in compositions comprising polybutene inhibit or prevent gingivitis, caries, staining, fungi, bacteria and plaque build-up in the oral cavity by means of the delivery system.

Abstract: The present invention provides a culture of isolated adult human dental pulp stem cells that can differentiate into dentin/pulp tissue that can be used to produce a tooth in a human being. The present invention further provides a method of regenerating human dentin/pulp tissue.

Abstract: A confectionery composition comprising: (i) an effective amount of a natural plant extract selected from tea, gold thread, honeysuckle, magnolia extracts and mixtures thereof; (ii) an oral care active selected from the group consisting of anti-calculus agents; anti-plaque agents; fluoride ion source; desensitising agents; oral malodour control agents; H2 antagonists; and mixtures thereof; (iii) less than about 10% water; and (iv) a suitable confectionery carrier material.

Abstract: A two component desensitizing dentifrice composition is disclosed which comprises a first dentifrice component containing an enzyme such as papain and a second dentifrice component containing an ionic surfactant such as sodium lauryl sulfate, the first and second dentifrice components being maintained separate from the other until dispensed for application to teeth whereby enzyme activity is maintained with improved dentifrice foaming characteristics.

Abstract: According to the present invention, an isolated and purified DNA sequence which encodes a lantibiotic, mutacin I, is disclosed. The nucleic acid sequence is set forth in SEQ ID No: 1 and the amino acid sequence is set forth in SEQ ID No: 2.

Abstract: The invention features articles for delivery of a biologically active substance, methods for making such articles, and methods for treating an animal using the articles.

Abstract: Hydro-activated and/or oxygen activated aqueous, enzymatic, antimicrobials denture adhesive compositions are stabilized against enzymatic action prior to oral application of the adhesive by incorporating a thickener into the adhesive formulation so as to provide the forrmulation with an enzyme immobilizing viscosity which inhibits enzymatic action during processing and in the adhesive package. An illustrative, thickened, enzymatic adhesive with this enhancement contains glucose oxidase, glucose, lactoperoxidase and potassium thiocyanate together with a mixture of polyacrylic acid and polyvinylpyrrolidone in an amount to provide the adhesive with a viscosity of at least about 300,000 centipoises.

Abstract: An oral care composition having enhanced oral hygiene and antiplaque properties which comprises an orally acceptable vehicle containing a combination of an enzyme, cetylpyridinium chloride and a reducing agent.

Abstract: Use of at least a substance selected from the group comprising: glutathione, pharmaceutically acceptable esters and salts of glutathione, WR-2721, sodium mercaptoethansulfonate (MESNA), diethyldithiocarbonate, sodium thiosulfate, N-acetylcystene, cytochrome P450 and cysteamine as the active substance in the preparation of pharmaceutical compositions suitable for the removal of plaque, dental calculus (tartar) and dental stain from the tooth surface, also having an anti-halitosis function, and compositions thereof.

Abstract: Protease-resistant analogues of biologically active derivatives of human PTH are described. These analogs are intended for use in therapeutic preparations for the treatment of various medical conditions in which bone loss is encountered or is susceptible of being encountered. The analogs specified are hPTH(1-34) and hPTH(1-31). More particularly, protease-resistant analogs of PTH adapted for transdermal administration are described.

Abstract: An oral care composition having enhanced oral hygiene and lipophylic properties which comprises an orally acceptable vehicle containing a combination of an enzyme and a cyclodextrin.

Abstract: An orally consumable film composition for delivering breath freshening agents to the oral cavity which is rapidly dissolvable or dispersible in the oral cavity, the composition being comprised of a homogeneous mixture of a water dispersible film forming polymer and an enzyme.

Abstract: The present invention relates to an oral composition and an immunogenic composition for the suppression of the pathogenic effects of the intra-oral bacterium Porphyromonas gingivalis associated with periodontal disease.

Abstract: The present invention provides an antigenic composition, the composition comprising at least one recombinant protein. The recombinant protein comprises at least one epitope. The epitope is reactive with an antibody which is reactive with a polypeptide having the sequence set out in SEQ. ID. NO. 3 or SEQ. ID. NO. 5. The invention also provides methods and compositions for the production of the recombinant protein. Also provided are methods for the diagnosis, treatment and prevention of P. gingivalis infection.

Abstract: The present invention is based on the discovery that interspecies quorum sensing is related to biofilm formation. The present invention provides methods useful for treating or preventing biofilm formation and microbial infections associated with biofilm formation by using an agent that either increases LuxS-dependent pathway or interspecies quorum sensing signal. The present invention also provides compositions containing an anti-micorbial agent and an agent that either increases LuxS-dependent pathway or interspecies quorum sensing signal.

Abstract: The present invention relates to novel bacterial isolates identified by their 16S rRNA DNA, that cause periodontal disease in companion animals, polynucleotide sequences contained therein, polypeptides encoded by such polynucleotide sequences and vaccines comprising such bacteria, polynucleotides, or polypeptides. Also provided are methods for treating and preventing periodontal disease and kits for detecting and treating periodontal disease kits for detecting and preventing periodontal disease.

Abstract: A dental adhesive film that, when applied to dental material, assists in the remineralization of dental material that exhibit damage from caries, lesions in the enamel and open dentine channels. The active compound in the dental adhesive film is a finely divided, poorly soluble calcium salt of phosphates, fluorides, fluorophosphates and mixtures thereof. Optionally present may be hydroxyl, carbonate or chloride ions.

Abstract: A two component antiplaque dentifrice composition is disclosed which comprises first and second dentifrice components containing an enzyme such as papain and a metal salt such as stannous fluoride, the first and second dentifrice components being maintained separate from the other until dispensed for application to teeth.

Abstract: The present invention relates to soluble P. gingivalis polypeptides derived from PG32 and PG33 and to polynucleotides encoding these polypeptides. The P. gingivalis polypeptides and nucleotides can be used in compositions for use in raising an immune response in a subject against P. gingivalis and treating or preventing or reducing the severity of the condition known as periodontitis or in other conditions related to infection with P. gingivalis.

Abstract: A dual component antiplaque oral composition having antimalodor properties in which a first component contains an antibacterial agent and the second component contains a proteolytic enzyme, the first and second components are simultaneously combined for application to the teeth, the first and second components being physically segregated prior to use, the components when mixed upon application to teeth providing substantially antiplaque effect with superior antimalodor properties.

Abstract: A peroxidase-activating oral care composition, in accordance with an embodiment of the invention, includes a non-enzymatic, water-soluble hydrogen peroxide precursor and a pH-adjusting agent capable of producing a selected pH in an aqueous solution. The composition facilitates the rapid release of hydrogen peroxide and results in the activation of a peroxidase enzyme in an oral cavity. A process for manufacturing the oral care composition including obtaining the precursor, dispersing it in a non-hygroscopic material so as to coat or encapsulate it, obtaining and associating the coated or encapsulated particles with a pH-adjusting agent, and formulating the particles into an oral care composition is provided in another embodiment.

Abstract: An abrasive dentifrice composition which effects enhanced antiplaque and breath freshening properties which comprises an orally acceptable vehicle containing a combination of a safe and effective amount of an antibacterial agent and at least two enzyme ingredients.

Abstract: A two component composition comprises an anchor enzyme complex to degrade biofilm structures and a second anchor enzyme component having the capability to act directly upon the bacteria for a bactericidal effect.

Abstract: The present invention relates to promoting whole body health in humans and animals by using topical oral compositions comprising an antimicrobial agent, in particular stannous salts, such as stannous fluoride and stannous chloride in combination with a polymeric mineral surface active agent such as condensed polyphosphates or polyphosphonates. In addition to providing a spectrum of intraoral benefits, topical administration of the present compositions to the oral cavity surprisingly provides benefits to systemic health. In particular, the present invention relates to methods of using the present topical oral compositions to reduce the risk in development of cardiovascular disease, stroke, atherosclerosis, diabetes, severe respiratory infections, premature births and low birth weight, post-partum dysfunction in neurologic and developmental functions, and associated increased risk of mortality.

Abstract: A periodontal structure regeneration composition for treatment of periodontal disease is a mixture of particles of a bone growth material and free collagen. The periodontal regeneration composition is injected into the periodontal pocket through a needle. The composition may contain a thickener that increases the viscosity of the composition after the material has been injected into the periodontal pocket. The composition is available in pre-filled syringes offered in a kit that may also contain strips of surgical sponge or gauze that are sized to fit within a periodontal pocket, a tube of adhesive, a dental bur, a probe, a gauze placement tool, gauze counter and a brush for cleaning the dental bur.

Abstract: A method for the treatment and prevention of dental caries and periodontal diseases using bacteriophages and phage-encoded anti-bacterial enzymes to inhibit establishment of bacteria in the oral cavity is provided. Also provided are methods for studying the cell wall of an oral bacterium, a method for preventing spoilage of perishable items and a method for removing dextrans from surfaces utilized in sugar manufacture. Purified enzymes and the isolated DNA fragments encoding them are also provided.

Abstract: A periodontal structure regeneration composition for treatment of periodontal disease is a mixture of particles of a bone growth material and free collagen. All particles are sized to be less than 1 mm in diameter. The periodontal regeneration composition is injected into the periodontal pocket through an 18 gauge needle. The composition may contain a thickener that increases the viscosity of the composition after the material has been injected into the periodontal pocket. The composition is available in pre-filled syringes offered in a kit that may also contain strips of surgical sponge or gauze that are sized to fit within a periodontal pocket, a tube of adhesive, a dental bur, a probe, a gauze placement tool, gauze counter and a brush for cleaning the dental bur.

Abstract: The invention relates to the use of one or more compounds selected from compounds of formulae Ia and Ib, the physiologically compatible salts of compounds of formula Ia and Ib and the stereoisomer forms of compounds of formula La and Ib, wherein R1, R2, R3, R4 and n have the meaning cited in claim 1. Said compounds can be used advantageously in a preparation suitable for oral care.

Abstract: Dental compositions to inhibit the adherence and plaque and/or stains on teeth comprise one or more water-soluble block copolymers of polyoxyethylene/polyoxypropylene which have a structure with the polyoxypropylene block being sandwiched between two polyoxyethylene blocks together with an acidic poly-amino acid or an alkali metal salt thereof.

Abstract: This invention relates to novel and improved bleach-stable compositions and processes and methods of making such compositions. More particularly, the invention relates to providing improved dental compositions comprising an effective amount of a discontinuous phase consisting of one or more hydrophobic, inert, bleach-stable abrasive agents that are polymers, copolymers and crosspolymers of granular nature of about between 2 microns and 150 microns particle size, present in the operative range of about 10% and 75% with respect to the total weight of the composition, said abrasive agents are dispersed or otherwise distributed in a continuous phase comprising one or more bleaching actives emulsed in an inclusion complex polymer (ICP) of delayed water and saliva solubility said emulsified bleaching active being capable of forming a long lasting bleaching film on tooth surfaces and being present in the operative range of about 0.

Abstract: A lactic bacteria strain that is exogenous to the oral microflora is selected for its ability to adhere the pellicle of the teeth and to produce a growth inhibition factor. This strain is used for the preparation of a composition intended for reducing dental plaque and for treating or preventing root caries and other diseases related to Actinomyces naeslundii in mammals.

Abstract: The invention relates to compositions for treating tooth and/or bone tissue that contain calcium phosphates, calcium fluorides or calcium fluorophosphates, all of which being poorly soluble in water, and polyelectrolytes. The compositions can be cured and are suited for the smoothing, the reconstruction, and the remineralizing treatment of tooth and bone tissue, especially for eliminating microroughnesses.

Abstract: The invention provides methods, oral care products and kits for treating mouth tissues. In particular, the invention provides methods, oral care products and kits which comprise certain metal-binding peptides, peptide derivatives and peptide dimers that can reduce inflammation of tissues of the mouth and can reduce the damage done by reactive oxygen species (ROS) to such tissues.

Abstract: The present invention relates to oral care compositions, especially toothpastes, comprising: a safe and effective amount of phosphopeptide-amorphous calcium phosphate complex (“PP-ACP”); a safe and effective amount of a fluoride ion source; a safe and effective amount of a phosphate buffer; a pharmaceutically-acceptable topical, oral carrier; wherein the pH of the final composition is greater than 8 to about 12 and the composition has improved fluoride stability.

Abstract: An oral composition comprises water and a cyclic carbonate compound in a certain ratio. In this case, the ratio of the water and the cyclic carbonate compound is such that when the water and the cyclic carbonate compound are mixed together the mixture goes into a 2-phase state. Moreover, the oral composition may further comprise a polyol, and in this case the ratio of the water, the cyclic carbonate compound and the polyol is such that when the water, the cyclic carbonate compound and the polyol are mixed together the mixture goes into a 2-phase state. The oral composition has an excellent effect of removing accumulations on dental surfaces or between teeth through a physico-chemical action, rather than relying purely on a mechanical action.

Abstract: The present invention relates to a novel growth factor from bovine milk, milk products or milk product extracts. The present invention also relates to the use of recombinant DNA technology to isolate, clone and sequence nucleic acids encoding the mature and precursor forms of the growth factor and, in addition, to the use of these nucleic acids in the recombinant production of the growth factor.

Abstract: Hydro-activated and/or oxygen activated aqueous, enzymatic, antimicrobials denture adhesive compositions are stabilized against enzymatic action prior to oral application of the adhesive by incorporating a thickener into the adhesive formulation so as to provide the forrmulation with an enzyme immobilizing viscosity which inhibits enzymatic action during processing and in the adhesive package. An illustrative, thickened, enzymatic adhesive with this enhancement contains glucose oxidase, glucose, lactoperoxidase and potassium thiocyanate together with a mixture of polyacrylic acid and polyvinylpyrrolidone in an amount to provide the adhesive with a viscosity of at least about 300,000 centipoises.

Abstract: A composition and method for treating bacterial dental caries by the use of an effective amount of at least one lytic specific for the bacteria causing caries. The lytic enzyme is genetically coded for by a bacteriophage which may be specific for said bacteria.

Abstract: A composition and method for treating bacterial dental caries by the use of an effective amount of at least one lytic specific for the bacteria causing dental caries. The lytic enzyme is genetically coded for by a bacteriophage which may be specific for said bacteria.

Abstract: The present invention relates to oral care compositions, especially toothpastes, comprising: a safe and effective amount of phosphopeptide-amorphous calcium phosphate complex (“PP-ACP”); a safe and effective amount of a fluoride ion source; a pharmaceutically-acceptable topical, oral carrier, and a safe and effective amount of a calcium chelator, wherein the composition has improved fluoride stability.

Abstract: A dental bleaching gel composition having a long shelf life for use with an activator system to cause accelerated bleaching action over a shortened time period of a peroxide bleaching agent in the bleaching gel composition when applied upon a tooth surface for cosmetically whitening the tooth and/or for the treatment of stains or discolorations.

Abstract: The present invention discloses methods and test kits which are useful tools for the dentist and provide means for evaluating the periapical disease activity or inflammation and monitoring the need of continued or alternative medical treatment before finalizing the root treatment in teeth by measuring the presence or absence of MMPs in root canal exudates. The test kit is preferably constructed for chair-side use.

Abstract: A peroxidase-activating oral care composition, in accordance with an embodiment of the invention, includes a non-enzymatic, water-soluble hydrogen peroxide precursor and a pH-adjusting agent capable of producing a selected pH in an aqueous solution. The composition facilitates the rapid release of hydrogen peroxide and results in the activation of a peroxidase enzyme in an oral cavity. A process for manufacturing the oral care composition including obtaining the precursor, dispersing it in a non-hygroscopic material so as to coat or encapsulate it, obtaining and associating the coated or encapsulated particles with a pH-adjusting agent, and formulating the particles into an oral care composition is provided in another embodiment.

Abstract: A composition and method for treating bacterial dental caries by the use of an effective amount of at least one lytic specific for the bacteria causing dental caries. The lytic enzyme is genetically coded for by a bacteriophage which may be specific for said bacteria.

Abstract: Active enamel substances may be used for the preparation of a pharmaceutical or cosmetic composition for healing of a wound, improving healing of a wound, soft tissue regeneration or repair, or for preventing or treating infection or inflammation.

Abstract: A therapeutic or preventive agent for dental diseases which comprises, as an active ingredient, a substance inhibiting the binding between parathyroid hormone related peptide and a receptor thereof.

Abstract: Orthodontic remedies containing parathyroid hormone (PTH) or one or more PTH derivatives as the active ingredient(s).

Abstract: The patent disclosure describes advantageous compositions and methods for whitening and remineralizing teeth, for desensitizing teeth, and for treating dental caries.

Abstract: A periodontal structure regeneration composition for treatment of periodontal disease is a mixture of particles of a bone growth material and collagen. All particles are sized to be less than 1 mm in diameter. The periodontal regeneration composition is injected into the periodontal pocket through an 18 gauge needle. The composition is available in pre-filled syringes offered in a kit that may also contain strips of surgical sponge or gauze that are sized to fit within a periodontal pocket, a tube of adhesive, a dental bur, a probe, a gauze placement tool, gauze counter and a brush for cleaning the dental bur.