Abstract: Oral care composition for increasing deposition efficacy of a cooling sensate agent in the oral cavity. The oral care composition is made up of water and a calcium-containing abrasive to form a calcium-containing abrasive based carrier, and a cooling sensate agent comprising a N-substituted p-menthanecarboxamide containing compound.

Abstract: An agent for protection of tooth surfaces, in conjunction with conventional bleaching methods, by biomimetic deposition of fluorapatite, containing A at least one preformulated 50-1000 ?m thick gel film A, containing A1 at least one gel former, A2 water or a mixture of water and an organic solvent, A3 phosphate or hydrogen phosphate ions, A4 optionally fluoride, A5 optionally at least one amino acid, A6 optionally one carboxylic acid or a buffer system for a pH value from 4 to 7. B at least one 50 ?m to 5 mm thick gel film B, containing B1 at least one gel former, B2 water, B3 calcium ions Ca2+.

Abstract: The present invention recognizes that there exists a need for the treatment diseases, disorders and conditions that cause or are related to bad breath in general. The present invention provides devices and methods to address this need. A first aspect of the present invention is an oral device for a subject. A second aspect of the present invention is a method of treating a subject for a disease, disorder, condition, or a combination thereof, of the oral cavity with a device of the present invention. A third aspect of the present invention is a method of treating a subject for a disease, disorder, condition, or a combination thereof, of the oral cavity.

Abstract: A system for delivering molecular iodine or other substance into a pet's drinking water on a daily basis without exceeding the safe amount allowed for the pet. The system delivers a particular amount of molecular iodine into the pet water supply to achieve maximum benefit of I2 to reduce or eliminate bad pet breath and minimize total iodine in the pet diet so that 20-40 ?g/mL/Kg/day iodine is consumed for optimum thyroid health. The preferred method is to use a solution created by dissolving iodine crystals in absolute ethanol. The iodine will only be in solution as I2 for a short time as it undergoes out gassing and hydrolysis at neutral pH. The present invention removes the iodine from the drinking water after the pet drinks. Therefore, during the day, pets will get no additional iodine—only fresh water. Each enrolled pet is electronically recognized by the system.

Abstract: The present invention is related to a foamable composition of matter comprising iodine, water, a foam adjuvant, a surface-active agent and a gelling agent. This foamable composition, which may be provided in a propellant free foaming device, or alternatively may further comprise a propellant, evolves into foam, which is effective in the topical treatment and prevention of various skin disorders.

Abstract: A system and method for delivering molecular iodine or any other substance into a pet's drinking water on a daily basis without exceeding the safe amount allowed for the pet. The present invention delivers a particular amount of molecular iodine into the pet water supply to achieve maximum benefit of I2 to reduce or eliminate bad pet breath and minimize total iodine in the pet diet so that 20-40 ?g/mL/Kg/day iodine is consumed for optimum thyroid health. The preferred method is to use a solution created by dissolving iodine crystals in absolute ethanol. The iodine will only be in solution as I2 for a short time as it undergoes out gassing and hydrolysis at neutral pH. The present invention removes the iodine from the drinking water after the pet drinks. Therefore, during the day, pets will get no additional iodine—only fresh water from the water reservoir. Each enrolled pet is recognized by the system using an ID tag such as an RFID tag.

Abstract: A method for killing or substantially eradicating a pathogen in the upper respiratory tract of a mammal is disclosed. The method comprises generating molecular iodine (I2) in situ using an oxidant-reductant reaction with a minimum concentration of at least about 25 ppm of I2 and I2 comprises at least 40% of the total iodine atoms. A method for inhibiting superantigens using molecular iodine is also disclosed.

Abstract: Oral care compositions having improved taste, said compositions comprising: a carrier material; from about 0.001 to about 10%, by weight of the composition, of an oral care component selected from metal salts, antimicrobial agents, bad breath reduction agents, bleaching agents, surfactants, or a combination thereof; and from about 0.

Abstract: An abrasive dentifrice composition which effects enhanced antiplaque and breath freshening properties which comprises an orally acceptable vehicle containing a combination of a safe and effective amount of an antibacterial agent and at least two enzyme ingredients.

Abstract: The present invention is related to a foamable composition of matter comprising iodine, water, a foam adjuvant, a surface-active agent and a gelling agent. This foamable composition, which may be provided in a propellant free foaming device, or alternatively may further comprise a propellant, evolves into foam, which is effective in the topical treatment and prevention of various skin disorders.

Abstract: A system and method for delivering molecular iodine or any other substance into a pet's drinking water on a daily basis without exceeding the safe amount allowed for the pet. The present invention delivers a particular amount of molecular iodine into the pet water supply to achieve maximum benefit of I2 to reduce or eliminate bad pet breath and minimize total iodine in the pet diet so that 20-40 ?g/mL/Kg/day iodine is consumed for optimum thyroid health. The preferred method is to use a solution created by dissolving iodine crystals in absolute ethanol. The iodine will only be in solution as I2 for a short time as it undergoes out gassing and hydrolysis at neutral pH. The present invention removes the iodine from the drinking water after the pet drinks. Therefore, during the day, pets will get no additional iodine—only fresh water from the water reservoir. Each enrolled pet is recognized by the system using an ID tag such as an RFID tag.

Abstract: A dental composition which, e.g., eliminates or substantially reduces the discomfort and pain associated with dentinal hypersensitivity and exhibits enhanced anticaries and remineralization benefits, which composition contains a first component containing a calcium source, a second component containing an anion source and at least one of the components containing a basic amino acid in free or salt form, and the first and second components being maintained separate from each other until dispensed and combined for application to teeth.

Abstract: The present application relates to the induced remineralization of human tooth enamel and in particular to the building up of apatite on tooth material.

Abstract: The horse liniment is a veterinary composition for topical application for the relief of muscle and joint pain in horses. The composition contains, by weight, about 49% alcohol, 20% olive oil, 10% arnica, 14% creosote, 1% iodine, 2% turpentine, 2% camphor, and 2% alum. The ingredients may be mixed at room temperature, the powdered ingredients being soluble in the alcohol-olive oil base. The composition is applied topically to the affected muscles or joints in conventional manner as needed. The composition has been found to be effective, often with a single application, with increased range of motion, an absence or reduction of limping, increased energy, and other signs of a healthy, active horse.

Abstract: Use of osteopontin for reducing plaque bacterial growth on tooth enamel and dental formulations containing osteopontin.

Abstract: An oral care composition comprising a fused silica abrasive and a stannous ion source.

Abstract: The present invention provides antiseptic compositions that contain DMSO or DMA, an alcohol (e.g., isopropanol), and/or an additional antiseptic agent such as iodine. In certain embodiments, the antiseptic compositions may be used for skin disinfection and/or skin antisepsis (e.g., as applied via a swab).

Abstract: An iodine-based oral antibacterial treatment methodology involves applying an effective amount of an iodine-based oral antibacterial treatment to the inside of a human or animal mouth in the gum area between the gum and a tooth wall. The delivered treatment includes available iodine, including molecular iodine, and an iodine free radical initiator selected from the group consisting of chloride ions, bromide ions and mixtures thereof. Animals include pets, such as dogs and cats, as well as farm animals having teeth, e.g., horses, cows, goats and the like, and zoo animals having teeth, such as chimps, baboons, tigers and the like.

Abstract: In toothpaste, the addition of the Iodide ion by way of iodide salts, such as sodium iodide and potassium iodide, to a peroxide such as hydrogen peroxide in a basic medium yields free radical oxygen and water; generating large amounts of heat and depleting the Hydrogen Peroxide in a matter of minutes. The free radical oxygen generated in this reaction can be utilized to oxidize organic molecules that produce offending stains on select items, including artificial teeth and other dental appliances. Once the free radical oxygen has oxidized the offending molecule the color is lost and the solubility changes allowing any loose fragments of the offending molecule to be washed away in the solvent. The iodide ion catalyzes the reaction allowing for precise control over the speed at which the stain is removed without the need for other expensive, cumbersome energy adding equipment such as lights, lasers, heat sources, etc.

Abstract: The present invention is generally related to alcohol free, liquid ranitidine formulations for oral administration. In particular, the present invention is related to stable, syrup formulations having ranitidine as an active ingredient for oral administration, processes for making the same, and methods of their use. The ranitidine of the present invention is stable in non-polar media or media having a relatively low polarity such that the dielectric constant is less than about 60, and is achieved by using certain saccharides, certain relatively high molecular weight starches, and/or certain celluloses instead of alcohol.

Abstract: Dental bleaching compositions, for example in the form of liquids, gels, creams, pastes and ointments, comprising a peroxide releasing compound and from 1% to 35% by weight of a potassium-containing compound such as potassium nitrate, wherein the potassium nitrate is present in a safe and effective amount to prevent tooth hypersensitivity in the patient during the bleaching process. The potassium nitrate contemplated by the invention is compatible with peroxide yielding bleaching compounds such as peroxide, carbamide peroxide, calcium peroxide, zinc peroxide, magnesium peroxide and sodium perborate. Potassium nitrate is complimentary and synergistic with the peroxide bleaching agents contemplated by the invention and enhances the release of oxygen to the tooth enamel. Also contemplated are methods of bleaching teeth comprising application of the dental bleaching compositions of the invention.

Abstract: The invention relates to oral care compositions such as toothpaste, gels, tooth powders, mouthwashes, mouth rinses, gums, mouth sprays and lozenges comprising diglycerol. The diglycerol is used as a humectant in the compositions. The compositions may further comprise water, flavoring agents, active compounds, emulsifier, alcohol, sweeteners, thickening agents, surfactants, suspending agents, astringent and toning drug extracts, flavor correctants, abrasives or polishes, deodorizing agents, preservatives, flavoring buffers, whitening agents, wound-healing and inflammation inhibiting substances, colorants, dyes, pigments, abrasives, polishes, antimicrobial agents, pH buffers and other additives and fillers.

Abstract: Systems for delivering cosmetic and therapeutic actives to the oral cavity employ a strip comprising a first layer of material, a second layer comprising polybutene with a molecular weight of about 300 to about 3000, and a cosmetic or therapeutic active included within the second layer. Therapeutic and cosmetic actives in compositions comprising polybutene inhibit or prevent gingivitis, caries, staining, fungi, bacteria and plaque build-up in the oral cavity by means of the delivery system.

Abstract: A confectionery composition comprising: (i) an effective amount of a natural plant extract selected from tea, gold thread, honeysuckle, magnolia extracts and mixtures thereof; (ii) an oral care active selected from the group consisting of anti-calculus agents; anti-plaque agents; fluoride ion source; desensitising agents; oral malodour control agents; H2 antagonists; and mixtures thereof; (iii) less than about 10% water; and (iv) a suitable confectionery carrier material.

Abstract: A therapeutic composition for use as a nasal spray the aids in decongesting of the nasal passages by osmotic effect, thinning of mucus and stimulation of ciliary function. Preferred embodiments of the composition contain a sugar solution, a sodium bicarbonate solution, saline, glycerin, water, and a preservative.

Abstract: Disclosed is a color changing toothpaste which contains color reagents for interacting to provide a color change indicative of tooth brushing time. The color reagents comprise two separate color components which may be an FD&C dye, and FD&C lake or a natural food color, the two separate color components being adapted to interact after a predetermined brushing time to produce a third color. Optionally, the toothpaste may contain up to approximately 0.05% by weight of a foaming agent and other components such as a fluoride and a flavoring agent or flavor burst component.

Abstract: Parboiled rice flour is used in lieu of other grain flour in medical foods to minimize antigenicity of the medical food product.

Abstract: A new and improved formulation of a dual chain quaternary ammonium chloride compound and iodine/potassium iodide complex to serve as a disinfectant and sanitizer on surfaces and tissue as well as being utilized as an immersion solution in health care areas. The dual-quat with iodine formulation of the present invention is more useful over a wide range of areas and uses and is also more stable over a wide variety of water combinations. It improves efficacy, reduces toxicity, increases the spectrum of the antimicrobial effectiveness and broadens the effective usage of the complex into new areas of application.

Abstract: Disclosed are toothpaste compositions and a process for preparing such compositions comprising dental abrasive, humectant, fluidized polymer suspension and a suitable vehicle for the humectant, wherein the fluidized polymer suspension comprises: polyethylene glycol, carboxymethyl cellulose and hydrated thickening silica.

Abstract: A striped and/or speckled dentifrice stable to color bleeding, wherein at least one dentifrice component contains a colorant entrained in a high density polyethylene matrix having a melting point range as measured by DSC is between about 110.degree. C. and about 145.degree. C., whereby on storage substantially no visually observable colorant bleeding is present in any other dentifrice component.

Abstract: The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain agents useful are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

Abstract: A semi-paste oral preparation comprises, as effective ingredients, at least 0.1 to 20% by weight of povidone-iodine based on the total weight of the preparation, and 0 to 50 parts by weight of potassium iodide and 1 to 300 parts by weight of a sugar alcohol of an oligosaccharide as a base and stabilizer, the parts by weight being based on one part by weight of the povidone-iodine. This semi-paste oral preparation has a modest viscosity, good taste and good stability upon storage for a long time.

Abstract: A radiopaque composition for use in visualizing and cleaning root canal system anatomy, pathologies, anomalies, and iatrogenic conditions. The composition comprises a radiopaque iodine solution and a sodium hypochlorite solution. The iodine solution comprises diatrizoate meglumine and sodium iodine. The iodine solution and sodium hypochlorite solution are mixed in a ratio of between 5:95 to 95:5, by volume. Preferably, the iodine solution and sodium hypochlorite solution are mixed in a ratio of between 30:70 to 70:30, by volume. And more preferably, the iodine solution and sodium hypochlorite solution are mixed in a ratio of between 45:55 to 55:45, by volume. In use, the root canal system anatomy, anomaly, pathology, or iatrogenic condition to be visualized and addressed or treated is liberally flushed with the composition, preferably after the root canal system has been exposed.

Abstract: The object of the invention is a process for preparing a clodronate preparation. The process is characterized in that clodronate is crystallized as disodium clodronate tetrahydrate from an aqueous solution of disodium clodronate; the resulting disodium clodronate tetrahydrate is dry granulated by compressing in such a way that the crystal structure of the disodium clodronate tetrahydrate is preserved and by crumbling and screening the mass to granules of a sutiable size, the dry granulated disodium clodronate tetrahydrate is optionally mixed with suitable excipients, such as filling agents and gliding agents and, if necessary, disintegrants.

Abstract: Shaving compositions for use in the personal shaving process with a razor blade assembly include insoluble solid particulate additives. The shaving compositions may include one or more of the following: wetting agents, cleansing agents, lather producing compositions, emollients and mixtures thereof; and further includes at least one solid, insoluble particulate additive in a well dispersed suspension throughout said shaving composition. The solid additives are present in an effective amount to produce physical microscopic support for the blade of a razor blade assembly during the personal shaving process. By providing micro-support of the razor blade parallel to skin surface and above surface irregularities, the solid particulate additives provide improved razor blade glide, thereby preventing nicks and cuts, and also enhancing exfoliation of dead skin and removal of grease and oils, as well as improving hair extraction prior to cutting, thereby improving overall smoothness of the post-shaven skin.

Abstract: The present invention relates to oral hygiene and specifically to an improved method for adding chemotherapeutic agents to dental floss containing several multi-fiber bundles, to methods of treating the oral cavity with the improved dental floss and to the improved dental flosses per se.

Abstract: The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a thiazolium compound capable of inhibiting, and to some extent reversing, the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

Abstract: Shaving compositions for use in the personal shaving process with a razor blade assembly include insoluble solid particulate additives. The shaving compositions include a mixture of at least one wetting agent, at least one cleansing agent, at least one lather producing composition, and at least one emollient; and further include at least one solid, insoluble particulate additive in a well dispersed suspension throughout said shaving composition. The solid additives are present in an effective amount to produce physical microscopic support for the blade of a razor blade assembly during the personal shaving process. By providing micro-support of the razor blade parallel to skin surface and above surface irregularities, the solid particulate additives provide improved razor blade glide, thereby preventing nicks and cuts, and also enhancing exfoliation of dead skin and removal of grease and oils, as well as improving hair extraction prior to cutting, thereby improving overall smoothness of the post-shaven skin.

Abstract: A method for suppressing a bitter taste of material to be placed in mouth or in contact with mouth, such as foods, drinks, pharmaceuticals, comprises adding an acidic phospholipid or an acidic lysophospholipid to the material.

Abstract: An oral composition comprising (i) at least one fluoride compound and (ii) at least one 5- or 6-membered, substituted heterocyclic compound which contains 1 to 3 nitrogen atoms as ring hetero atoms, which may contain an oxygen or sulfur atom as a ring hetero atom, and which may be condensed with one or two 6-membered carbocyclic or heterocyclic rings, or a salt thereof. This oral composition is very effective for preventing carries of the teeth.

Abstract: The present invention relates to methods and agents for preventing the staining of teeth caused by the nonenzymatic browning of proteins in the oral cavity. Both oral and parenteral administration ft the agents are disclosed. Suitable agents for the inhibition of nonenzymatic browning may be formulated as rinses and toothpastes, and include compounds capable of reacting with the carbonyl moiety of the early glycosylation product resulting from the initial reaction of a target protein in the nonenzymatic browning reaction. Preferred agents are those having an active nitrogen-containing substituent, as well as amino acids, their esters and amides. These preparations may further include known anti-plaque agents such as chlorhexidine.

Abstract: A new delivery system for zinc compounds and the process for its preparation is disclosed, which has use in a variety of products including comestibles such as chewing gum compositions, confections, pharmaceuticals, food products such as vitamin preparations, dentifrice compositions and throat lozenges. More particularly, this invention relates to a process for preparing a zinc compound delivery system comprised of a zinc core material coated with a first hydrophilic coating comprising a hydrocolloid material and a second hydrophobic coating selected from the group consisting of fats, waxes and mixtures thereof. The delivery system provides enhanced masking of the bitter flavor characteristic of zinc compounds, as well as reduced grittiness with retained stability at the elevated temperatures of product formulation.

Abstract: In the technology of applying, spraying, or sponging antimicrobially effective amounts of aqueous iodophor peroxide solutions to the udder surfaces of cows, or other animals to be milked prior to milking, the present invention comprises the improvement which avoids iodides and staining which consists essentially of the step of shampooing said udders with a non-staining shampoo containing (a) from about 0.5% to 2% of iodine in a povidone-iodine complex and (b) about 0.5% to 5% of hydrogen peroxide as a nascent oxygen source, said individual components (a) and (b) being combined, with water, at the time of use and having been maintained dry and out of contact with one another in a container or receptacle.

Abstract: Methods for reproducibly labelling viable cells with cyanine dyes that do not significantly affect cell viability. Applications for labelled cells include using labelled red blood cells to distinguish post-transfusional bleeding from immunologic reaction and using dilution to measure growth rate of cultured cells.

Abstract: Pre- and post-operative dental and surgical procedures in and on structures and areas of the oral cavity are maintained sterile by the application thereto of an antimicrobially enhanced aqueous solution of an iodophor constituting a source of iodine and a peroxide as a source of oxygen, the aqueous solution ensuring sterility of the structures and areas in the oral cavity before, during and after the operating procedures therein and retarding or inhibiting microbial regrowth on and in the structures and areas in a dental or surgical environment. The iodophor is preferably a povidone iodine complex soluble in water and the peroxide is preferably hydrogen peroxide, the oxygen from the peroxide acting to enhance the antimicrobial activity of the iodine derived from the povidone iodine complex.

Abstract: Plaque is inhibited and oral hygiene promoted including reduction in caries formation by dispersing emulsan in water and contacting the aqueous dispersion with dental surfaces. Emulsan may be dispersed in dental preparation toothpaste or mouthwash.

Abstract: Dentifrices comprising two components each of which comprises ingredients usually present in toothpastes or toothpowders, one component containing an iodophor as a source of derived iodine and the other component containing a source of active or nascent oxygen. The two components are kept out of contact with one another and separately filled into a suitable package so arranged and constructed that the components can be admixed and dispensed together to form an antimicrobial, antiplaque non-toxic dentifrice ready for use.

Abstract: A method is described for controlling and treating periodontal diseases by applying to the teeth and periodontium an oral lavage comprised of an aqueous solution of hydrogen peroxide and a povidone-iodine complex.

Abstract: A method is described for controlling and treating microorganisms implicated in diseases of the teeth and periodontium by applying to the teeth and periodontium an oral lavage comprised of an admixture of selected antimicrobial agents and selected oxygenating agents in predetermined proportions, and compositions therefor and use thereof.

Abstract: The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a thiazolium compound capable of inhibiting, and to some extent reversing, the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.