Ammonia, Amine, Or Derivative Thereof (e.g., Urea, Etc.) Patents (Class 424/54)
  • Patent number: 10441517
    Abstract: An oral care composition comprising: (a) arginine, in free or salt form; and (b) zinc oxide and zinc citrate. The oral care composition can reduce or inhibit biofilm formation in an oral cavity.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: October 15, 2019
    Assignee: Colgate-Palmolive Company
    Inventors: Michael Prencipe, Yun Xu, Xiao Yi Huang
  • Patent number: 10434037
    Abstract: The present invention relates to a kit and a probe for detecting porous dental hydroxyapatite that includes a protein capable of binding porous dental hydroxyapatite or a detector thereof. The invention also relates to a method for detecting a condition involving porous dental hydroxyapatite that includes detecting in or on a tooth or a sample of the tooth of a subject a protein bound to porous dental hydroxyapatite. The invention also relates to methods for detecting a hypomineralization developmental dental defect or detecting intact and/or broken MIH enamel, and to a kit and method for removing a protein bound to porous dental hydroxyapatite.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: October 8, 2019
    Assignee: INCISIVE TECHNOLOGIES PTY LTD
    Inventors: Michael James Hubbard, Jonathan Edward Mangum
  • Patent number: 10413516
    Abstract: A method of preparing a thin film, the method comprising: (a) mixing a lipid, emulsifier, and solvent to provide a uniform first mixture; (b) contacting an active ingredient with the uniform first mixture to provide a thickened second mixture; (c) contacting a binder with the thickened second mixture to provide a slurry; and (d) hot extruding, casting, and condensing the slurry to provide the thin film; or cooling, shearing, mixing, casting, and condensing the slurry to provide the thin film.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: September 17, 2019
    Assignee: CURE Pharmaceutical Corporation
    Inventors: Eric Allen, Robert Steven Davidson, Jose Bernardo
  • Patent number: 10398645
    Abstract: A method for blocking, neutralizing, or killing microorganisms that cause infectious disease in a mammal prior to or during the mammal encountering a contaminated environment or item includes: identifying a contaminated environment or item, wherein the contaminated environment or item is known or expected to be contaminated with harmful viral, fungal, or bacterial microorganisms; and administering a therapeutically effective amount of a barrier-forming composition to a mucosa of the mammal prior to or during the mammal encountering the contaminated environment or item. The barrier-forming composition provides a barrier on the mucosa that inhibits the microorganisms from contacting the mucosa. Other related methods are also included.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: September 3, 2019
    Assignee: ARMS PHARMACEUTICAL, LLC
    Inventors: Brian Vincent Sokol, Afif Mahmoud Ghannoum
  • Patent number: 10278906
    Abstract: An oral care composition comprising zinc phosphate, stannous fluoride and an organic acid buffer system, as well as methods of using the same.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: May 7, 2019
    Assignee: Colgate-Palmolive Company
    Inventors: Aarti Rege, Michael Prencipe, Madhuleena Bhadra
  • Patent number: 10258551
    Abstract: An oral care composition comprising zinc phosphate and stannous fluoride.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: April 16, 2019
    Assignee: Colgate-Palmolive Company
    Inventors: Aarti Rege, Richard Sullivan, David Suriano, Nihal Dogu, Mary Colligan, Steven Fisher, Andre Morgan
  • Patent number: 10196482
    Abstract: A polyether dendrimer of formula (I), wherein the symbols and indices have the following meanings: each Y is independently [R1—(O—CH2—CH2)p—O—]; each Z is independently [R2—(O—CH2—CH2)q(O—CH(CH3)—CH2)r—O—]; each R1 is independently H, CH3 or C2-C4-alkyl; each R2 is independently linear or branched C8-C22-alkyl; X is H or C1-C4-alkyl; m is 1, 2, 3, 4, 5 or 6; n, o are rational positive numbers >0, with the proviso that the sum of n and o is 2m; p is a natural number from 5 to 50; q is a natural number from 1 to 50; r is 0 or is a natural number from 1 to 30, with the proviso that 5?q+r?50, and ˜ denotes the bonding of the respective group to the dendron scaffold, is useful for solubilizing sparingly-water soluble active ingredients, in particular pesticides.
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: February 5, 2019
    Assignee: BASF SE
    Inventors: Murat Mertoglu, Jean-Pierre Berkan Lindner, Ann-Kathrin Marguerre, Rainer Berghaus
  • Patent number: 10179159
    Abstract: The topical medicament gel formulation of the present invention includes an anesthetic, an anti-microbial, an oxidant, a nutrient, a diuretic, an opioid, an anti-emetic, an anti-seizure drug, and a non-steroidal anti-inflammatory drug (NSAID), USP in a molecular, as opposed to a salt form, as the active ingredient. Additional constituents illustratively include a skin penetration enhancer and a gelling agent. This invention deals with problems commonly associated with topical application of local medicaments such as: slow onset of action; need for occlusion; and rapid loss of effect due to rapid systemic dispersion. The invention permits enhanced penetration of the medicament and thereby allows for a lesser total dosage of pharmaceutically active ingredient. The use of a lesser total dosage also decreases systemic toxicity.
    Type: Grant
    Filed: August 8, 2007
    Date of Patent: January 15, 2019
    Inventor: Scott Wepfer
  • Patent number: 10166206
    Abstract: The present invention relates to improved topical gel compositions comprising an active agent, and uses thereof.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: January 1, 2019
    Assignee: SEBELA INTERNATIONAL BERMUDA LIMITED
    Inventors: Bhushan Hardas, Donna Dalton, Petra Scheppler, Anja Buch, Peter Boderke
  • Patent number: 10166205
    Abstract: A gel composition for topical administration that includes: naftifine or a pharmaceutically acceptable salt thereof; a solvent; a non-carbomer rheology modifier; a polysorbate solubilizing agent; and an amine pH adjuster.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: January 1, 2019
    Assignee: SEBELA INTERNATIONAL BERMUDA LIMITED
    Inventors: Bhushan Hardas, Donna Dalton
  • Patent number: 10137178
    Abstract: A papain dental gel composition is disclosed for the atraumatic treatment of caries which comprises papain with a final activity of at least 3,000 U/mg, wherein the papain is bio-encapsulated in a mixture of pH=7 buffer-C3-6 polyol-pectin-C2-6 alkanolamine-nonionic emulsifier, together with pharmaceutically acceptable coloring agents, preservatives and solvents. A method of preparing said papain composition is also disclosed.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: November 27, 2018
    Assignee: BRIX USA, LLC
    Inventor: Mauricio Dobboletta
  • Patent number: 10131744
    Abstract: The present invention relates to veterinary compositions and methods of treating and/or preventing mastitis in non-human mammals. More particularly, the present invention relates to the treatment of mastitis in cows. The veterinary composition comprises a water soluble, locally-acting, antimicrobial amine functional polyamide polymer.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: November 20, 2018
    Assignees: MERIAL INC., Genzyme Corporation
    Inventors: Susan Mancini Cady, Izabela Galeska, Pradeep K. Dhal
  • Patent number: 10117823
    Abstract: Non-toxic consumable compositions and formulations having chelator and base are disclosed with synergistic effects on microbial metabolism and/or growth and/or pathogenic effectors and their use to promote and maintain health in mammals. The non-toxic consumable compositions have more than one chelator and/or more than one base. Methods for selecting said chelator and base composition and methods for detecting conditions in which selected compositions may be used are also disclosed. The synergistic compositions and methods can be used for maintaining health, promoting health and treating diseases.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: November 6, 2018
    Assignee: Primal Therapies, Inc.
    Inventor: Emily A. Stein
  • Patent number: 10030155
    Abstract: An ionic liquid can disperse graphene at a high concentration. The ionic liquid can be represented by general formula (1): in which R1 and R5 may be the same or different and each independently represents a substituted or unsubstituted C1-7 linear or branched alkyl group; R2 is represented by formula (2): in which R6 and R7 may be the same or different and each independently represents a C1-4 linear or branched alkylene group, and m represents an integer of 1-5; R3 and R4 may be the same or different and each independently represent a hydrogen atom, substituted or unsubstituted C1-4 linear or branched alkyl group; X? represents a counter ion; and n represents 0-30.
    Type: Grant
    Filed: May 14, 2013
    Date of Patent: July 24, 2018
    Assignee: THE UNIVERSITY OF TOKYO
    Inventors: Takuzo Aida, Chiyoung Park, Saisuwan Ravi, Michio Matsumoto
  • Patent number: 9968528
    Abstract: Disclosed herein are oral care compositions comprising: a) one or more pyrophosphate compounds, wherein the total concentration of pyrophosphate compounds in the composition is 0.5 wt % to 1.5 wt %, based on the weight of the oral care composition; b) one or more thickening gums, wherein the total concentration of thickening gums in the composition is 1.25 wt % to 1.6 wt %, based on the weight of the oral care composition; and c) a metal ion source.
    Type: Grant
    Filed: December 18, 2012
    Date of Patent: May 15, 2018
    Assignee: Colgate-Palmolive Company
    Inventors: Yun Xu, Xiaoyi Huang, Yuanhui Xie, Xiongfei Qin
  • Patent number: 9901092
    Abstract: Provided is a pest control agent in the form of a suspension, which exhibits excellent dispersion stability for a long time without forming a hard cake due to settling and separation of solid particles or without losing fluidity due to gelation even when a cationic pest control active ingredient and/or an acid is used. Specifically provided is a pest control agent in the form of a suspension, which contains (a) a cationic pest control active ingredient and/or an acid, (b) a nonionic thickening agent, (c) a nonionic surface active agent, (d) a solid active ingredient and (e) water.
    Type: Grant
    Filed: September 10, 2007
    Date of Patent: February 27, 2018
    Assignee: Nippon Soda Co., Ltd.
    Inventors: Hiroshi Dairiki, Eriko Okada
  • Patent number: 9854831
    Abstract: An oral product includes a body that is wholly receivable in an oral cavity. The body includes a mouth-stable polymer matrix, cellulosic fibers embedded in the mouth-stable polymer matrix, and nicotine or a derivative thereof dispersed in the mouth-stable polymer matrix. The oral product is adapted to release the nicotine or derivative thereof from the body when the body is received within the oral cavity and exposed to saliva.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: January 2, 2018
    Assignee: ALTRIA CLIENT SERVICES LLC
    Inventors: Feng Gao, Frank Scott Atchley, Gregory Griscik, Christopher Joseph DiNovi, Phillip M. Hulan, Diane Gee, Jason Flora, Shuzhong Zhuang
  • Patent number: 9795554
    Abstract: Disclosed herein are oral care compositions comprising an orally acceptable vehicle, calcium carbonate and a preservative system comprising benzyl alcohol, benzoic acid or a salt of benzoic acid; and an alkylene glycol.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: October 24, 2017
    Assignee: Colgate-Palmolive Company
    Inventors: Jason Nesta, Melissa Martinetti, Aileen Cabelly, James R. Brown, Suman Chopra
  • Patent number: 9757315
    Abstract: Provided is a tooth whitener that is excellent in immediate effectivity of a gloss imparting effect on teeth and a tooth whitening effect. The tooth whitener is provided with a composition (A) and a composition (B) in a separate state, and which is to be used by applying the composition (A) and the composition (B) alternately to teeth.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: September 12, 2017
    Assignee: Kao Corporation
    Inventors: Gen Nakauchi, Yoshiyuki Eshita, Keizo Takahashi
  • Patent number: 9675542
    Abstract: Described herein are oral compositions comprising an extract obtained from Arialaceae, Zingiberaceae, Lamiaceae, Fabaceae, Solanaceae, Punicaceae. Asteraceae or mixtures thereof; Their uses for alleviating dry mouth is also described.
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: June 13, 2017
    Assignee: Colgate-Palmolive Company
    Inventors: Wei Wang, Harsh M. Trivedi, Mahmoud Hassan
  • Patent number: 9675540
    Abstract: Methods of preparing a dentifrice comprising polymer matrix film with menthol therein are disclosed. The methods comprise combining a polymer matrix film that comprises hydrophobic additives and is free of a low solubility flavorant such as menthol with a dentifrice base comprising a low solubility flavorant such as menthol and maintaining the combined polymer matrix film with the dentifrice base comprising low solubility flavorant for an amount of time sufficient for an amount of a low solubility flavorant to transfer from the dentifrice base comprising low solubility flavorant to the polymer matrix film and establish an equilibrium of menthol concentration between the polymer matrix film and the dentifrice base. Products comprising low solubility flavorant-free polymer matrix film in a dentifrice base comprising low solubility flavorant are also disclosed.
    Type: Grant
    Filed: December 13, 2010
    Date of Patent: June 13, 2017
    Assignee: Colgate-Palmolive Company
    Inventors: Ben Gu, Mahmoud Hassan
  • Patent number: 9597276
    Abstract: The invention solves the problem of the practical realization of an effective prophylactic composition which uses available and safe components and which can be recommended for preventing the growth of candidiasis of the skin and/or mucous membranes in humans in the following risk group: sufferers of diabetes mellitus, people with blood diseases, immune deficiency and other serious pathologies, patents after a course of hormone therapy, antibiotic treatment or chemotherapy, as well as for babies and pregnant women; and for people using tooth implants. The composition for the prophylaxis of candidiasis comprises active components, with the active components used being xylitol in a quantity of 0.3-20.0% by mass and sodium or potassium alginate or a mixture thereof in a quantity of 0.01-2.0% by mass, as well as inert components.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: March 21, 2017
    Assignee: OBSHCHESTVO S OGRANICHENNOJ OTVETSTVENNOST'YU “WDS”
    Inventors: Tamaz Omarovich Manasherov, Svetlana Konstantinovna Matelo, Tat'yana Vladimirovna Kupets
  • Patent number: 9527849
    Abstract: The present invention relates to new salts of pyrazolopyrimidinone represented by formula (I), and pharmaceutically acceptable polymorph, solvate, hydrate, dehydrate, co-crystallization, anhydrous, or amorphous form thereof, the pharmaceutical compositions, and a pharmaceutical unit dosage form containing the same, wherein x represents organic or inorganic acids, preferable maleic acid, succinic acid, methanesulfonic acid, hydrochloric acid, etc. The invention further relates to co-crystals or complexes of compounds of pyrazolopyrimidinone and pharmaceutical compositions containing the same. The present invention also relates to a process for the preparation, use thereof and pharmaceutical preparation containing the salts or crystalline forms.
    Type: Grant
    Filed: August 14, 2012
    Date of Patent: December 27, 2016
    Assignees: TOPHARMAN SHANGHAI CO., LTD., SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES TOPHARMAN SHANDONG CO., LTD
    Inventors: Jianfeng Li, Guanghui Tian, Zhen Wang, Jin Suo, Xiangrui Jiang, Zheng Liu, Xiaojun Yang, Zhu Xie, Xianguo Zhao, Weiliang Zhu, Hualiang Jiang, Jingshan Shen
  • Patent number: 9504736
    Abstract: The inventors have unexpectedly discovered that shock and/or potential multi-organ failure due to shock can be effectively treated by administration of liquid high-dose protease inhibitor formulations to a location upstream of where pancreatic proteases are introduced into the gastrointestinal tract. Most preferably, administration is directly to the stomach, for example, via nasogastric tube under a protocol effective to treat shock by such administration without the need of providing significant quantities of the protease inhibitor to the jejunum and/or ileum.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: November 29, 2016
    Assignees: The Regents of the University of California, Inflammagen, LLC
    Inventors: Geert W. Schmid-Schonbein, Yung-Tsai (Andrew) Lee, Jeng Wei
  • Patent number: 9481848
    Abstract: The present invention provides a compound comprising the reaction product of a hydrcarbyl substituted amine with an itaconate, such as an N-substituted 4-carboxypyrrolidin-2-one, and methods of employing the same in lubricating compositions. The lubricating compositions containing the N-substituted 4-carboxypyrrolidin-2-one are preferably intended to be employed in a method for lubricating a mechanical device, such as an automatic or manual transmission. However, it is envisioned that the compound can be employed in engine oil lubricants and any other type of functional fluid.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: November 1, 2016
    Assignee: The Lubrizol Corporation
    Inventors: Daniel J. Saccomando, Richard J. Vickerman, Yanshi Zhang
  • Patent number: 9474295
    Abstract: A method of purifying a Luo Han Guo extract includes contacting the Luo Han Guo extract with activated carbon and a macroporous polymeric adsorbent resin, an ion exchange resin, or both.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: October 25, 2016
    Assignee: Tate & Lyle Ingredients Americas LLC
    Inventors: Brian Timothy Pohrte, Timothy C. Schunk, Elber F. Tejada
  • Patent number: 9468592
    Abstract: Described herein are toothpaste compositions comprising an orally acceptable vehicle; calcium carbonate; and a binder system comprising guar gum and at least one cellulose polymer.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: October 18, 2016
    Assignee: Colgate-Palmolive Company
    Inventors: Rolando Plata, Xiaojing Lu, Yuyan Zeng, Chengkang Tan
  • Patent number: 9452982
    Abstract: A method of providing a cooling effect to a product includes the incorporation into the product of at least one compound of the formula I in which m is a number between 0 and 2, X, Y and Z are selected independently from the group consisting of H, halogen, OH, Me, Et, MeO and EtO, and R1, R2 and R3together comprise at least 6 carbons, selected such that (a) (i) R1 is selected from the group consisting of H, Me, Et, isopropyl and C4-C5 branched alkyl; and (ii) R2 and R3 are independently selected from the group consisting of Me, Et, isopropyl and C4-branched alkyl; or (b) any two or all of R1, R2 and R3 together form a monocyclic, bicyclic or tricyclic radical having up to 10 carbons. The compounds confer substantial cooling effects on compositions applied to the skin or taken orally, such as toothpastes, mouthwashes, foodstuffs, beverages, confectionery, tobacco products, skin creams and ointments.
    Type: Grant
    Filed: August 14, 2006
    Date of Patent: September 27, 2016
    Assignee: Givaudan, S.A.
    Inventors: Karen Ann Bell, Christophe C. Galopin, Jay Patrick Slack, Lori W. Tigani
  • Patent number: 9345655
    Abstract: Aqueous oral compositions containing a cationic steroidal compound and a quaternary ammonium compound are suitable for treating conditions of the oral cavity.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: May 24, 2016
    Assignee: BRIGHAM YOUNG UNIVERSITY
    Inventors: Joe Vazquez, Dandan Chen, Harsh M. Trivedi, Ammanuel Mehreteab, Laurence Du-Thumm, Gregory Szewzyk, Zhigang Hao
  • Patent number: 9320696
    Abstract: Described herein are compositions comprising a MMP-13 inhibitor, and methods of using the same.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: April 26, 2016
    Assignee: Colgate-Palmolive Company
    Inventors: Wei Wang, Virginia Barnes, Harsh M. Trivedi, Tao Xu
  • Patent number: 9265712
    Abstract: A dental bleaching composition comprises a dental bleaching agent, polyvinylpyrrolidone, and at least 0.1% water. The bleaching composition may include a liquid component, flavoring agent, basic substance, and/or desensitizing agent as desired. Polyvinylpyrrolidone avoids acid etching and chelation of teeth that were problematic in bleaches using carbomer as a thickener. A delivery system for delivering the bleaching composition comprises the aforementioned dental bleaching composition in combination with a moisture-resistant barrier layer such as a dental tray or a flexible strip of material.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: February 23, 2016
    Assignee: Ultradent Products, Inc.
    Inventor: Tianming Chen
  • Patent number: 9254255
    Abstract: A dental care product comprises an orally acceptable carrier or excipient, and a bacterial resistance copolymer, which comprises a zwitterionic block and a charged anchoring block, wherein the anchoring block binds to tooth surfaces by electrostatic attraction, and the zwitterionic block extends outwardly to reduce the attachment of bacteria to tooth surfaces.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: February 9, 2016
    Assignee: CHUNG-YUAN CHRISTIAN UNIVERSITY
    Inventors: Yung Chang, Yu-Ju Shih, Bor-Shiunn Lee, Da-Ming Wang, Juin-Yih Lai
  • Patent number: 9241885
    Abstract: Disclosed are oral care compositions, including therapeutic rinses, especially mouthrinses and methods of use to provide significantly enhanced antimicrobial activity, thereby reducing oral bacteria and promoting overall oral health. The present compositions are formulated to deliver increased bioavailable levels of cationic antimicrobials, particularly quaternary ammonium compounds such as cetylpyridinium chloride (CPC) and are useful for preventing and treating diseases or conditions of the oral cavity including dental plaque, caries, gingivitis, periodontal disease and breath malodor. The present compositions are formulated to be essentially free of anionic, nonionic or amphoteric surfactants, which have been found to have a negative effect on bioavailability of the quaternary ammonium compounds and thus, their antimicrobial efficacy.
    Type: Grant
    Filed: January 18, 2005
    Date of Patent: January 26, 2016
    Assignee: THE PROCTER & GAMBLE COMPANY
    Inventors: Rebecca Lynn Roberge, Andrew Lee Wong
  • Patent number: 9144578
    Abstract: The invention relates to a fixed-dose association of phytate and zinc in synergic proportions for use in the treatment of crystallization of hydroxyapatite. Advantageously, said association is in a molar ratio between the phytate and the zinc exceeding 4:1. The invention also relates to the use of said association for manufacturing a drug for the treatment, prophylaxis and/or prevention crystallization of hydroxyapatite in humans.
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: September 29, 2015
    Assignee: Universitat de les Illes Balears
    Inventors: Felix Grases Freixedas, Joan Perello Bestard, Bernat Isern Amengual, Pilar Sanchis Cortes, Rafael M. Prieto Almirall, Antonia Costa Bauza
  • Patent number: 9125899
    Abstract: The present invention relates to molecules which function as modulators (i.e., inhibitors and agonists) of the Ras-homologous (Rho) family of small GTPases (e.g. Rac, Cdc42 and Rho GTPases) and their use to treat diseases, including cancers (including solid tumors-medulloblastoma, ovarian, breast, head and neck, testicular, prostate among others and hematologic malignancies-B cell lymphoma, where these GTPases are overexpressed or hyperactivated), sporadic and genetic diseases where activation of Rho GTPases plays a pivotal role (Menkes disease, rheumatoid arthritis, atherosclerosis, diabetes (type 1), Huntington's disease and Alzheimer's disease) which are mediated through these proteins. Compounds according to the present invention may also be used as a therapy for the treatment of Entamoeba spp. or Acanthamoeba spp, infections, especially including Entamoeba histolytica.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: September 8, 2015
    Assignee: STC.UNM
    Inventors: Angela-Wandinger Ness, Laurie Hudson, Larry Sklar, Zurab Surviladze, Tudor Oprea
  • Publication number: 20150147361
    Abstract: The invention relates to the use of sphingosine based compounds, in particular phytosphingosine compounds, in the protection of hydroxyapatite containing materials such as teeth and bone. Such compounds are especially useful in the treatment and prevention of dental caries, dental erosion, dentine hypersensitivity and tartar (dental calculus) formation. Methods and devices are also provided for preventing biofilm formation using sphingosine based compounds. Compositions comprising sphingosine based compounds are also provided.
    Type: Application
    Filed: April 26, 2013
    Publication date: May 28, 2015
    Applicant: Stichting VU-VUmc
    Inventors: Floris Jacob Bikker, Engelmundus Cornelis Ignatius Veerman, Marianne Valentijn-Benz, Willem Van'T Hof
  • Publication number: 20150132347
    Abstract: Oral formulations are provided for prevention and treatment of adverse oral conditions such as gingivitis, periodontal disease, removal of calculus to improve dental hygiene, and control of dental plaque and biofilm. Use of the formulations for prevention and treatment of other adverse oral conditions including inflammation and oxidative and/or free radical damage within the oral cavity are provided. Treatable conditions may relate to other conditions or diseases, including diabetes, AIDS and cancer. Oral formulations containing a biocompatible chelating agent, and a permeation enhancer such as methylsulfonylmethane (MSM) are disclosed. Components of the formulations are multifunctional and Generally Regarded As Safe.
    Type: Application
    Filed: May 3, 2013
    Publication date: May 14, 2015
    Inventors: Rajiv Bhushan, Jerry Gin, Amit Goswamy
  • Publication number: 20150125503
    Abstract: The invention provides improvements of lantibiotics useful for reducing the numbers of microbes or the reproduction of microbes in or on subjects or objects. One embodiment of the invention provides variants of antibiotics wherein the amino acid at position (1) is changed to Ile or Gly, the amino acid at position (4) is changed to an Ala, the amino acid at position (4) is removed, the amino acid at position (5) is changed to an Ala, or wherein, as in the case of MU1140, the amino acid at position (13) is Arg, the Arg at position (13) is substituted with Asp, or combinations of two or more these changes or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 22, 2013
    Publication date: May 7, 2015
    Inventors: Jeffrey D. Hillman, James Leif Smith, Shawanda R. Wilson-Stanford
  • Publication number: 20150079009
    Abstract: The present invention relates to the use of a combination of glycine, proline, and optionally a natural or synthetic film-forming polymer, and/or lysine and/or leucine, to prepare a composition for the treatment of mucositis induced by radiation or chemotherapy.
    Type: Application
    Filed: November 25, 2014
    Publication date: March 19, 2015
    Inventors: Franco Conti, Francesco Saverio Dioguardi
  • Patent number: 8980233
    Abstract: Disclosed is a dentifrice composition comprising an orally acceptable vehicle, an abrasive particulate and a surfactant system comprising an anionic surfactant comprising a C8-C16 fatty acid glutamate salt and a nonionic surfactant comprising a C8-C16 alkyl glucoside.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: March 17, 2015
    Assignee: Tom's of Maine, Inc.
    Inventors: Tammy Swett, Julie Venell, Chantal Bergeron, Mark Dobrovolny, Stefan Gafner
  • Patent number: 8980229
    Abstract: The invention encompasses compositions and methods for treating and modifying surfaces of teeth, which compositions include calcium and magnesium containing silicates or silica, cationic polymer modified silica or combinations thereof. The composition when applied to the teeth or a tooth surface deposit on such surfaces to repair acid damaged enamel and prevent further erosion of a tooth surface.
    Type: Grant
    Filed: April 1, 2009
    Date of Patent: March 17, 2015
    Assignee: Colgate-Palmolive Company
    Inventors: Shira Pilch, James Gerard Masters
  • Patent number: 8980232
    Abstract: A dental care product comprises an orally acceptable carrier or excipient, and a bacterial resistance copolymer, which comprises a zwitterionic block and a charged anchoring block, wherein the anchoring block binds to tooth surfaces by electrostatic attraction, and the zwitterionic block extends outwardly to reduce the attachment of bacteria to tooth surfaces.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: March 17, 2015
    Assignee: Chung Yuan Christian University
    Inventors: Yung Chang, Yu-Ju Shih, Bor-Shiunn Lee, Ruoh-Chyu Ruaan, Da-Ming Wang, Juin-Yih Lai
  • Patent number: 8974805
    Abstract: The present invention relates to a dental cleanser composition for improving adhesion to teeth, and more particularly to, a dental cleanser composition which functions to remove not only a smear layer from the dentin surface of an exposed tooth root, but also oral bacteria, and thus is effective in improving adhesion to teeth in periodontal surgery. The present invention provides a dental cleanser composition containing sodium ethylene diaminotetraacetate and octyl phenol ethoxylate which is a surfactant. Sodium ethylene diaminotetraacetate in the composition functions to remove a smear layer on the tooth root surface and has antibacterial activity, and octyl phenol ethoxylate in the composition functions to lipopolysaccharide. Thus, the composition improves adhesion to teeth in periodontal surgery.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: March 10, 2015
    Assignee: Nano Intelligent Biomedical Engineering Corporation
    Inventors: Chong-Pyoung Chung, Yoon-Jeong Park, Jue-Yeon Lee
  • Patent number: 8968710
    Abstract: A topical anesthetic is provided containing about 3 wt % to 10 wt % tetracaine in a vehicle suitable for administration to the skin or mucosa. The vehicle for transporting the tetracaine includes a water soluble mucoadhesive or a combination of mucoadhesives such as a high molecular weight poly(ethylene oxide) homopolymer and a cellulose polymer. The vehicle also includes propylene glycol. The tetracaine is ground into a powder and is suspended in a plasticized hydrocarbon gel which completes the vehicle.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: March 3, 2015
    Inventors: Alan J. Wickenhauser, Stephen E. Peipert
  • Patent number: 8968709
    Abstract: Dental compositions are provided comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof: wherein n is an integer from about 2 to about 5.
    Type: Grant
    Filed: July 10, 2008
    Date of Patent: March 3, 2015
    Assignee: 3M Innovative Properties Company
    Inventors: Jie Yang, Bhaskar V. Velamakanni, Sumita B Mitra, Alphonsus V. Pocius, John J. Stofko, Jr., Jeremy M. Yarwood
  • Patent number: 8955528
    Abstract: The instant application is an all-natural denture cream designed to remove stains, clean, disinfect, and shine the denture with minimal effort within seconds There is also an added double headed brush that can be used with the cream, with a curved easy grip feature that will allow for easy cleaning experience. The brush is designed to reach those hard to access spots of the denture that could not be otherwise accessed by the fingers alone.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: February 17, 2015
    Inventors: Guillermo Escobar, Jorge Leonardo Valderrama
  • Publication number: 20150044147
    Abstract: The composition for management of periodontal diseases includes a gel matrix having a polymer system and a plurality of microspheres dispersed in the polymer system. The polymer system contains about one-half a dose of medicament, while the microspheres contain the remainder. Upon administration of the composition into the periodontal cavity, the medicament in the polymer system provides an initial therapeutic benefit, while the remainder of the medication is released over time via degradation of the microspheres. This biphasic pattern of medicament delivery provides increased efficacy of the medicament through sustained delivery of the same.
    Type: Application
    Filed: October 22, 2014
    Publication date: February 12, 2015
    Inventors: NOHA MOHAMED ZAKI RAYAD, IBRAHIM MAGHRABI, MOHAMED MOSTAFA HAFEZ MAHMOUD
  • Patent number: 8951509
    Abstract: The invention relates to novel optionally quaternized or protonated condensation polymers having at least one heterocyclic end-group connected to the polymer backbone through a unit derived from an alkylamide, the connection comprising an optionally substituted ethylene group and to the use thereof in body care products and household products.
    Type: Grant
    Filed: February 23, 2007
    Date of Patent: February 10, 2015
    Assignee: DSM IP Assets B.V.
    Inventors: Raphael Beumer, Franciscus Derks, Christine Mendrok
  • Publication number: 20150004105
    Abstract: Oral care compositions comprising one or more active agents and hydroxypropyl cellulose, and that are liquid at or below room temperature and which form a two-phase cloudy system at body temperature. In certain embodiments the active agent is a mineralizing agent, an anti-caries agent, an anti-inflammatory agent, an antibacterial agent, an antifungal agent, an anti-malodour agent or a mixture thereof.
    Type: Application
    Filed: December 11, 2012
    Publication date: January 1, 2015
    Inventors: Mark Ieuan Edwards, Simon King, Nisha Patel
  • Publication number: 20140369941
    Abstract: Described herein are aqueous oral compositions comprising cationic steroidal compound and a quaternary ammonium compound; and methods for making and using the same.
    Type: Application
    Filed: December 21, 2011
    Publication date: December 18, 2014
    Applicant: BRIGHAM YOUNG UNIVERSITY
    Inventors: Joe Vazquez, Dandan Chen, Harsh M. Trivedi, Ammanuel Mehreteab, Laurence Du-Thumm, Gregory Szewczyk, Zhigang Hao