Ammonia, Amine, Or Derivative Thereof (e.g., Urea, Etc.) Patents (Class 424/54)
  • Patent number: 12059465
    Abstract: Edible compositions are provided and comprise a soluble mineral component and/or a phosphate component in amounts effective for use as an oral medicament. The soluble mineral component comprises one or more minerals selected from the group consisting of zinc, manganese, tin, copper, and mixtures thereof. The edible compositions are advantageously companion animal chews, treats or supplements. Further disclosed are methods of making the chews, treats or supplements as are methods of treating conditions of the oral cavity.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: August 13, 2024
    Assignee: Mars, Incorporated
    Inventors: Edward Russell Cox, Douglas Joseph Dobrozsi, Thomas Edward Huetter, Allan John Lepine, Susan Ruth Beyer
  • Patent number: 11826452
    Abstract: A mouth rinse composition with a cationic antimicrobial agent and an anti-stain agent, which is a functionalized polyethylene glycol. A dentifrice composition with a cationic antimicrobial agent and an anti-stain agent, which is a functionalized polyethylene glycol. The cationic antimicrobial agent is a quaternary ammonium salt, such as cetyl pyridinium chloride, or a metal ion source, such as stannous fluoride.
    Type: Grant
    Filed: November 1, 2021
    Date of Patent: November 28, 2023
    Assignee: The Procter & Gamble Company
    Inventors: Niranjan Ramji, Douglas Craig Scott
  • Patent number: 11752083
    Abstract: An aqueous composition with a higher-than-neutral pH includes a significant amount of one or more surfactants and large amounts of osmotically active solutes. This composition, as well as an acidic counterpart and solid materials, can be used in a variety of applications such as wound care, oral care, medical equipment reprocessing, healthcare acquired infection and implant treatment.
    Type: Grant
    Filed: September 2, 2018
    Date of Patent: September 12, 2023
    Assignee: Next Science IP Holdings Pty Ltd
    Inventor: Matthew Franco Myntti
  • Patent number: 11554157
    Abstract: The present disclosure provides pharmaceutical compositions for treating fungal and bacterial infections. The pharmaceutical compositions of the disclosure comprise a cationic surfactant, a chelating agent, and at least one solvent. The pharmaceutical compositions of the disclosure can be used to treat drug-sensitive or multi drug-resistant bacterial or fungal infections.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: January 17, 2023
    Assignee: NEW MEXICO TECH UNIVERSITY RESEARCH PARK CORPORATION
    Inventors: Snezna Rogelj, Danielle Nicole Turner
  • Patent number: 11547702
    Abstract: Disclosed is use of amlexanox or a salt thereof or a solvate thereof in preparation of a drug having an inhibitory action on the smooth muscle cells, in particular a drug for preventing and treating vascular restenosis. Further disclosed is a medical device, particularly a drug stent, the surface of which is distributed with amlexanox or the salt thereof or the pharmaceutical composition thereof. Amlexanox has an activity in inhibition of the proliferation of smooth muscle cells, has a low inhibitory property of the endothelial cell growth, is particularly suitable for applying on a medical device to prevent the incidence of vascular restenosis, while not delaying the repair of endothelium.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: January 10, 2023
    Assignee: MICROPORT SINICA CO., LTD.
    Inventors: Lu Chen, Junfei Li, Fei Chen, Xiao Cheng
  • Patent number: 11413228
    Abstract: Provided herein is a method for removing a chemical stain from a dental surface or inhibiting chemical staining of a dental surface, comprising contacting the dental surface with an oral care composition comprising zinc phosphate and an orally acceptable carrier.
    Type: Grant
    Filed: July 7, 2020
    Date of Patent: August 16, 2022
    Assignee: Colgate-Palmolive Company
    Inventors: Aarti Rege, David Suriano, Richard Sullivan
  • Patent number: 11344486
    Abstract: A soluble zinc polyphosphate complex made by combining ingredients which include an organic zinc salt and a plurality of long chain polyphosphates having 6 or more phosphate polymer units, the organic zinc salt and long chain polyphosphates being mixed in amounts that provide a phosphorus to zinc mole ratio of 15:1 to about 55:1. Further provided is a method of making this soluble zinc polyphosphate.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: May 31, 2022
    Assignee: Colgate-Palmolive Company
    Inventors: Baohua Qiao, Long Pan, Gregory Szewczyk, Ravi Subramanyam, Shiri Nawrocki, Viktor Dubovoy
  • Patent number: 11337902
    Abstract: An aqueous oral care fluoride treatment composition, a method of providing fluoride to a patient's tooth surface, and a method of reducing the incidence of dental caries, wherein the composition includes: 0.1 wt-% to 3.0 wt-% of a crosslinked poly acid having carboxylic acid side groups; a pharmaceutically acceptable buffer; 1.0 wt-% to 2.5 wt-% of sodium fluoride; 0.025 wt-% to 1.75 wt-% of a multivalent cation salt; and at least 60 wt-% water; wherein the weight percentages are based on the total weight of the aqueous composition.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: May 24, 2022
    Assignee: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Yizhong Wang, Tiffany T. Ton, Melinda B. Gustafson, Jennifer Post, Paul R. Klaiber, Carola A. Carrera Vidal, Joel D. Oxman
  • Patent number: 11229620
    Abstract: The present invention relates to purified 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt thereof, and a method for preparing such compound. The compound has at least 90% (w/w) purity. The present invention is also directed to a pharmaceutical composition comprises the purified compound and a pharmaceutically acceptable carrier. The present invention is further directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: January 25, 2022
    Assignee: Olatec Therapeutics LLC
    Inventor: Joseph St. Laurent
  • Patent number: 11229591
    Abstract: Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc oxide and amino acid hydrochloride with a slight molar excess of amino acid hydrohalide, as well as oral care compositions comprising said complexes made according to said method.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: January 25, 2022
    Assignee: Colgate-Palmolive Company
    Inventors: Stanislav Jaracz, Long Pan
  • Patent number: 11160894
    Abstract: The present invention relates to the field of perfumery. It relates more particularly to perfume dispensing device. The device of the present invention comprises dispensing means and a liquid composition including a perfume and selected compounds which impacts the fragrance perception diffused in the surrounding air during use.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: November 2, 2021
    Assignee: Firmenich SA
    Inventors: Nicholas O'Leary, Simon Hurry, Aude Daugeron-Jouault, James Blumire
  • Patent number: 11117906
    Abstract: Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc oxide and amino acid hydrochloride in a solvent comprising a polyol, as well as oral care compositions comprising said complexes made according to said method.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: September 14, 2021
    Assignee: Colgate-Palmolive Company
    Inventors: Zhigang Hao, Chi-Yuan Cheng, Tatiana Brinzari, Long Pan, Ravi Subramanyam, Lauren Evans, Sergio Leite
  • Patent number: 11091502
    Abstract: Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc halide and amino acid free base in a solvent comprising a polyol, as well as oral care compositions comprising said complexes made according to said method.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: August 17, 2021
    Assignee: Colgate-Palmolive Company
    Inventors: Zhigang Hao, Chi-Yuan Cheng, Tatiana Brinzari, Long Pan, Ravi Subramanyam
  • Patent number: 11000810
    Abstract: Membranes, methods of making the membranes, and methods of using the membranes are described herein. The membranes can comprise a support layer, and a selective polymer layer disposed on the support layer. The selective polymer layer can comprise an oxidatively stable carrier and a borate additive dispersed within a hydrophilic polymer matrix. The oxidatively stable carrier can comprise a quaternaryammonium hydroxide carrier (e.g., a mobile carrier such as a small molecule quaternaryammonium hydroxide, or a fixed carrier such as a quaternaryammonium hydroxide-containing polymer), a quaternaryammonium fluoride carrier (e.g., a mobile carrier such as a small molecule quaternaryammonium fluoride, or a fixed carrier such as a quaternaryammonium fluoride-containing polymer), or a combination thereof. The borate additive can comprise a borate salt, a boric acid, or a combination thereof. The membranes can exhibit selective permeability to gases.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: May 11, 2021
    Assignee: Ohio State Innovation Foundation
    Inventors: W. S. Winston Ho, Varun Vakharia, Witopo Salim
  • Patent number: 10993894
    Abstract: The invention relates generally to liquids such as mouth rinses for the prevention and elimination of bad breath as well as for the reduction of oral microorganisms responsible for the development of dental plaque and tooth decay. In particular, the present invention relates to a method of preparing non-alcohol or reduced alcohol mouth rinses effective at preventing the above-mentioned problems.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: May 4, 2021
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Robert Gambogi, Carolyn J. Mordas
  • Patent number: 10912731
    Abstract: This application provides, among other things, novel aqueous biphasic oral care compositions comprising two distinct aqueous phases, useful for combining and delivering poorly compatible ingredients, for example to deliver effective levels of cationic antibacterial agents in combination with anionic polymers, e.g. that protect against erosion and staining, by addition of a stabilizing amount of a polyamine, e.g. lysine, and methods for making and using the same.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: February 9, 2021
    Assignee: Colgate-Palmolive Company
    Inventors: Carl Myers, Rehana Begum-Gafur, Jeffrey Merl Miller, Ekta Makwana
  • Patent number: 10736828
    Abstract: Provided herein is a method for removing a chemical stain from a dental surface or inhibiting chemical staining of a dental surface, comprising contacting the dental surface with an oral care composition comprising zinc phosphate and an orally acceptable carrier.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: August 11, 2020
    Assignee: Colgate-Palmolive Company
    Inventors: Aarti Rege, David Suriano, Richard Sullivan
  • Patent number: 10729667
    Abstract: The present invention relates to improved topical gel compositions comprising an active agent, and uses thereof.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: August 4, 2020
    Inventors: Bhushan Hardas, Donna Dalton, Petra Scheppler, Anja Buch, Peter Boderke
  • Patent number: 10709648
    Abstract: An oral care composition comprising zinc phosphate, stannous fluoride and an organic acid buffer system, as well as methods of using the same.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: July 14, 2020
    Assignee: Colgate-Palmolive Company
    Inventors: Aarti Rege, Michael Prencipe, Madhuleena Bhadra
  • Patent number: 10695303
    Abstract: The present invention relates to improved topical gel compositions comprising an active agent, and uses thereof.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: June 30, 2020
    Assignee: Sebela Ireland Limited
    Inventors: Bhushan Hardas, Donna Dalton
  • Patent number: 10640463
    Abstract: The present invention provides a crystalline salt of chlorhexidine chloride having a spherical morphology under Scanning Electron Microscopy (SEM) comprising a chloride anion and a cation selected from the group consisting of calcium, sodium, potassium, magnesium, zinc, strontium or iron, processes for the preparation of the salt, compositions, pharmaceutical compositions and uses thereof in medicine. Also provided are crystalline forms of the salt and fibres comprising the same.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: May 5, 2020
    Assignee: Queen Mary University of London
    Inventors: Michael Cattel, Gleb Sukhorukov, Saroash Shahid, Dong Luo
  • Patent number: 10568829
    Abstract: Disclosed is a fiber elasticity conserving hair relaxer composition having an alkalinity of at least pH 12 comprising a fiber elasticity conserving amount of at least one hair fiber elasticity conserving agent selected from the group consisting of poly-organosiloxanes containing, per molecule, at least one siloxyl unit substituted with at least one group having one or more of a sterically hindered piperidinyl functional group. The composition substantially ameliorates the loss of hair fiber elasticity that frequently occurs during the hair relaxing step of a process for relaxing the natural curl of hair under such strongly alkaline conditions.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: February 25, 2020
    Assignee: Avlon Industries, Inc.
    Inventor: Ali N. Syed
  • Patent number: 10555883
    Abstract: This invention relates to oral care compositions comprising a basic amino acid in free or salt from (e.g., free form arginine); zinc oxide and zinc citrate; and a fluoride source comprising stannous fluoride.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: February 11, 2020
    Assignee: Colgate-Palmolive Company
    Inventors: Paul Thomson, Nihal Dogu, Michael Prencipe, Amy Russo, Hans Stettler, Andre Michelle Morgan
  • Patent number: 10441517
    Abstract: An oral care composition comprising: (a) arginine, in free or salt form; and (b) zinc oxide and zinc citrate. The oral care composition can reduce or inhibit biofilm formation in an oral cavity.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: October 15, 2019
    Assignee: Colgate-Palmolive Company
    Inventors: Michael Prencipe, Yun Xu, Xiao Yi Huang
  • Patent number: 10434037
    Abstract: The present invention relates to a kit and a probe for detecting porous dental hydroxyapatite that includes a protein capable of binding porous dental hydroxyapatite or a detector thereof. The invention also relates to a method for detecting a condition involving porous dental hydroxyapatite that includes detecting in or on a tooth or a sample of the tooth of a subject a protein bound to porous dental hydroxyapatite. The invention also relates to methods for detecting a hypomineralization developmental dental defect or detecting intact and/or broken MIH enamel, and to a kit and method for removing a protein bound to porous dental hydroxyapatite.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: October 8, 2019
    Assignee: INCISIVE TECHNOLOGIES PTY LTD
    Inventors: Michael James Hubbard, Jonathan Edward Mangum
  • Patent number: 10413516
    Abstract: A method of preparing a thin film, the method comprising: (a) mixing a lipid, emulsifier, and solvent to provide a uniform first mixture; (b) contacting an active ingredient with the uniform first mixture to provide a thickened second mixture; (c) contacting a binder with the thickened second mixture to provide a slurry; and (d) hot extruding, casting, and condensing the slurry to provide the thin film; or cooling, shearing, mixing, casting, and condensing the slurry to provide the thin film.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: September 17, 2019
    Assignee: CURE Pharmaceutical Corporation
    Inventors: Eric Allen, Robert Steven Davidson, Jose Bernardo
  • Patent number: 10398645
    Abstract: A method for blocking, neutralizing, or killing microorganisms that cause infectious disease in a mammal prior to or during the mammal encountering a contaminated environment or item includes: identifying a contaminated environment or item, wherein the contaminated environment or item is known or expected to be contaminated with harmful viral, fungal, or bacterial microorganisms; and administering a therapeutically effective amount of a barrier-forming composition to a mucosa of the mammal prior to or during the mammal encountering the contaminated environment or item. The barrier-forming composition provides a barrier on the mucosa that inhibits the microorganisms from contacting the mucosa. Other related methods are also included.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: September 3, 2019
    Assignee: ARMS PHARMACEUTICAL, LLC
    Inventors: Brian Vincent Sokol, Afif Mahmoud Ghannoum
  • Patent number: 10278906
    Abstract: An oral care composition comprising zinc phosphate, stannous fluoride and an organic acid buffer system, as well as methods of using the same.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: May 7, 2019
    Assignee: Colgate-Palmolive Company
    Inventors: Aarti Rege, Michael Prencipe, Madhuleena Bhadra
  • Patent number: 10258551
    Abstract: An oral care composition comprising zinc phosphate and stannous fluoride.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: April 16, 2019
    Assignee: Colgate-Palmolive Company
    Inventors: Aarti Rege, Richard Sullivan, David Suriano, Nihal Dogu, Mary Colligan, Steven Fisher, Andre Morgan
  • Patent number: 10196482
    Abstract: A polyether dendrimer of formula (I), wherein the symbols and indices have the following meanings: each Y is independently [R1—(O—CH2—CH2)p—O—]; each Z is independently [R2—(O—CH2—CH2)q(O—CH(CH3)—CH2)r—O—]; each R1 is independently H, CH3 or C2-C4-alkyl; each R2 is independently linear or branched C8-C22-alkyl; X is H or C1-C4-alkyl; m is 1, 2, 3, 4, 5 or 6; n, o are rational positive numbers >0, with the proviso that the sum of n and o is 2m; p is a natural number from 5 to 50; q is a natural number from 1 to 50; r is 0 or is a natural number from 1 to 30, with the proviso that 5?q+r?50, and ˜ denotes the bonding of the respective group to the dendron scaffold, is useful for solubilizing sparingly-water soluble active ingredients, in particular pesticides.
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: February 5, 2019
    Assignee: BASF SE
    Inventors: Murat Mertoglu, Jean-Pierre Berkan Lindner, Ann-Kathrin Marguerre, Rainer Berghaus
  • Patent number: 10179159
    Abstract: The topical medicament gel formulation of the present invention includes an anesthetic, an anti-microbial, an oxidant, a nutrient, a diuretic, an opioid, an anti-emetic, an anti-seizure drug, and a non-steroidal anti-inflammatory drug (NSAID), USP in a molecular, as opposed to a salt form, as the active ingredient. Additional constituents illustratively include a skin penetration enhancer and a gelling agent. This invention deals with problems commonly associated with topical application of local medicaments such as: slow onset of action; need for occlusion; and rapid loss of effect due to rapid systemic dispersion. The invention permits enhanced penetration of the medicament and thereby allows for a lesser total dosage of pharmaceutically active ingredient. The use of a lesser total dosage also decreases systemic toxicity.
    Type: Grant
    Filed: August 8, 2007
    Date of Patent: January 15, 2019
    Inventor: Scott Wepfer
  • Patent number: 10166205
    Abstract: A gel composition for topical administration that includes: naftifine or a pharmaceutically acceptable salt thereof; a solvent; a non-carbomer rheology modifier; a polysorbate solubilizing agent; and an amine pH adjuster.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: January 1, 2019
    Assignee: SEBELA INTERNATIONAL BERMUDA LIMITED
    Inventors: Bhushan Hardas, Donna Dalton
  • Patent number: 10166206
    Abstract: The present invention relates to improved topical gel compositions comprising an active agent, and uses thereof.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: January 1, 2019
    Assignee: SEBELA INTERNATIONAL BERMUDA LIMITED
    Inventors: Bhushan Hardas, Donna Dalton, Petra Scheppler, Anja Buch, Peter Boderke
  • Patent number: 10137178
    Abstract: A papain dental gel composition is disclosed for the atraumatic treatment of caries which comprises papain with a final activity of at least 3,000 U/mg, wherein the papain is bio-encapsulated in a mixture of pH=7 buffer-C3-6 polyol-pectin-C2-6 alkanolamine-nonionic emulsifier, together with pharmaceutically acceptable coloring agents, preservatives and solvents. A method of preparing said papain composition is also disclosed.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: November 27, 2018
    Assignee: BRIX USA, LLC
    Inventor: Mauricio Dobboletta
  • Patent number: 10131744
    Abstract: The present invention relates to veterinary compositions and methods of treating and/or preventing mastitis in non-human mammals. More particularly, the present invention relates to the treatment of mastitis in cows. The veterinary composition comprises a water soluble, locally-acting, antimicrobial amine functional polyamide polymer.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: November 20, 2018
    Assignees: MERIAL INC., Genzyme Corporation
    Inventors: Susan Mancini Cady, Izabela Galeska, Pradeep K. Dhal
  • Patent number: 10117823
    Abstract: Non-toxic consumable compositions and formulations having chelator and base are disclosed with synergistic effects on microbial metabolism and/or growth and/or pathogenic effectors and their use to promote and maintain health in mammals. The non-toxic consumable compositions have more than one chelator and/or more than one base. Methods for selecting said chelator and base composition and methods for detecting conditions in which selected compositions may be used are also disclosed. The synergistic compositions and methods can be used for maintaining health, promoting health and treating diseases.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: November 6, 2018
    Assignee: Primal Therapies, Inc.
    Inventor: Emily A. Stein
  • Patent number: 10030155
    Abstract: An ionic liquid can disperse graphene at a high concentration. The ionic liquid can be represented by general formula (1): in which R1 and R5 may be the same or different and each independently represents a substituted or unsubstituted C1-7 linear or branched alkyl group; R2 is represented by formula (2): in which R6 and R7 may be the same or different and each independently represents a C1-4 linear or branched alkylene group, and m represents an integer of 1-5; R3 and R4 may be the same or different and each independently represent a hydrogen atom, substituted or unsubstituted C1-4 linear or branched alkyl group; X? represents a counter ion; and n represents 0-30.
    Type: Grant
    Filed: May 14, 2013
    Date of Patent: July 24, 2018
    Assignee: THE UNIVERSITY OF TOKYO
    Inventors: Takuzo Aida, Chiyoung Park, Saisuwan Ravi, Michio Matsumoto
  • Patent number: 9968528
    Abstract: Disclosed herein are oral care compositions comprising: a) one or more pyrophosphate compounds, wherein the total concentration of pyrophosphate compounds in the composition is 0.5 wt % to 1.5 wt %, based on the weight of the oral care composition; b) one or more thickening gums, wherein the total concentration of thickening gums in the composition is 1.25 wt % to 1.6 wt %, based on the weight of the oral care composition; and c) a metal ion source.
    Type: Grant
    Filed: December 18, 2012
    Date of Patent: May 15, 2018
    Assignee: Colgate-Palmolive Company
    Inventors: Yun Xu, Xiaoyi Huang, Yuanhui Xie, Xiongfei Qin
  • Patent number: 9901092
    Abstract: Provided is a pest control agent in the form of a suspension, which exhibits excellent dispersion stability for a long time without forming a hard cake due to settling and separation of solid particles or without losing fluidity due to gelation even when a cationic pest control active ingredient and/or an acid is used. Specifically provided is a pest control agent in the form of a suspension, which contains (a) a cationic pest control active ingredient and/or an acid, (b) a nonionic thickening agent, (c) a nonionic surface active agent, (d) a solid active ingredient and (e) water.
    Type: Grant
    Filed: September 10, 2007
    Date of Patent: February 27, 2018
    Assignee: Nippon Soda Co., Ltd.
    Inventors: Hiroshi Dairiki, Eriko Okada
  • Patent number: 9854831
    Abstract: An oral product includes a body that is wholly receivable in an oral cavity. The body includes a mouth-stable polymer matrix, cellulosic fibers embedded in the mouth-stable polymer matrix, and nicotine or a derivative thereof dispersed in the mouth-stable polymer matrix. The oral product is adapted to release the nicotine or derivative thereof from the body when the body is received within the oral cavity and exposed to saliva.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: January 2, 2018
    Assignee: ALTRIA CLIENT SERVICES LLC
    Inventors: Feng Gao, Frank Scott Atchley, Gregory Griscik, Christopher Joseph DiNovi, Phillip M. Hulan, Diane Gee, Jason Flora, Shuzhong Zhuang
  • Patent number: 9795554
    Abstract: Disclosed herein are oral care compositions comprising an orally acceptable vehicle, calcium carbonate and a preservative system comprising benzyl alcohol, benzoic acid or a salt of benzoic acid; and an alkylene glycol.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: October 24, 2017
    Assignee: Colgate-Palmolive Company
    Inventors: Jason Nesta, Melissa Martinetti, Aileen Cabelly, James R. Brown, Suman Chopra
  • Patent number: 9757315
    Abstract: Provided is a tooth whitener that is excellent in immediate effectivity of a gloss imparting effect on teeth and a tooth whitening effect. The tooth whitener is provided with a composition (A) and a composition (B) in a separate state, and which is to be used by applying the composition (A) and the composition (B) alternately to teeth.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: September 12, 2017
    Assignee: Kao Corporation
    Inventors: Gen Nakauchi, Yoshiyuki Eshita, Keizo Takahashi
  • Patent number: 9675542
    Abstract: Described herein are oral compositions comprising an extract obtained from Arialaceae, Zingiberaceae, Lamiaceae, Fabaceae, Solanaceae, Punicaceae. Asteraceae or mixtures thereof; Their uses for alleviating dry mouth is also described.
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: June 13, 2017
    Assignee: Colgate-Palmolive Company
    Inventors: Wei Wang, Harsh M. Trivedi, Mahmoud Hassan
  • Patent number: 9675540
    Abstract: Methods of preparing a dentifrice comprising polymer matrix film with menthol therein are disclosed. The methods comprise combining a polymer matrix film that comprises hydrophobic additives and is free of a low solubility flavorant such as menthol with a dentifrice base comprising a low solubility flavorant such as menthol and maintaining the combined polymer matrix film with the dentifrice base comprising low solubility flavorant for an amount of time sufficient for an amount of a low solubility flavorant to transfer from the dentifrice base comprising low solubility flavorant to the polymer matrix film and establish an equilibrium of menthol concentration between the polymer matrix film and the dentifrice base. Products comprising low solubility flavorant-free polymer matrix film in a dentifrice base comprising low solubility flavorant are also disclosed.
    Type: Grant
    Filed: December 13, 2010
    Date of Patent: June 13, 2017
    Assignee: Colgate-Palmolive Company
    Inventors: Ben Gu, Mahmoud Hassan
  • Patent number: 9597276
    Abstract: The invention solves the problem of the practical realization of an effective prophylactic composition which uses available and safe components and which can be recommended for preventing the growth of candidiasis of the skin and/or mucous membranes in humans in the following risk group: sufferers of diabetes mellitus, people with blood diseases, immune deficiency and other serious pathologies, patents after a course of hormone therapy, antibiotic treatment or chemotherapy, as well as for babies and pregnant women; and for people using tooth implants. The composition for the prophylaxis of candidiasis comprises active components, with the active components used being xylitol in a quantity of 0.3-20.0% by mass and sodium or potassium alginate or a mixture thereof in a quantity of 0.01-2.0% by mass, as well as inert components.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: March 21, 2017
    Assignee: OBSHCHESTVO S OGRANICHENNOJ OTVETSTVENNOST'YU “WDS”
    Inventors: Tamaz Omarovich Manasherov, Svetlana Konstantinovna Matelo, Tat'yana Vladimirovna Kupets
  • Patent number: 9527849
    Abstract: The present invention relates to new salts of pyrazolopyrimidinone represented by formula (I), and pharmaceutically acceptable polymorph, solvate, hydrate, dehydrate, co-crystallization, anhydrous, or amorphous form thereof, the pharmaceutical compositions, and a pharmaceutical unit dosage form containing the same, wherein x represents organic or inorganic acids, preferable maleic acid, succinic acid, methanesulfonic acid, hydrochloric acid, etc. The invention further relates to co-crystals or complexes of compounds of pyrazolopyrimidinone and pharmaceutical compositions containing the same. The present invention also relates to a process for the preparation, use thereof and pharmaceutical preparation containing the salts or crystalline forms.
    Type: Grant
    Filed: August 14, 2012
    Date of Patent: December 27, 2016
    Assignees: TOPHARMAN SHANGHAI CO., LTD., SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES TOPHARMAN SHANDONG CO., LTD
    Inventors: Jianfeng Li, Guanghui Tian, Zhen Wang, Jin Suo, Xiangrui Jiang, Zheng Liu, Xiaojun Yang, Zhu Xie, Xianguo Zhao, Weiliang Zhu, Hualiang Jiang, Jingshan Shen
  • Patent number: 9504736
    Abstract: The inventors have unexpectedly discovered that shock and/or potential multi-organ failure due to shock can be effectively treated by administration of liquid high-dose protease inhibitor formulations to a location upstream of where pancreatic proteases are introduced into the gastrointestinal tract. Most preferably, administration is directly to the stomach, for example, via nasogastric tube under a protocol effective to treat shock by such administration without the need of providing significant quantities of the protease inhibitor to the jejunum and/or ileum.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: November 29, 2016
    Assignees: The Regents of the University of California, Inflammagen, LLC
    Inventors: Geert W. Schmid-Schonbein, Yung-Tsai (Andrew) Lee, Jeng Wei
  • Patent number: 9481848
    Abstract: The present invention provides a compound comprising the reaction product of a hydrcarbyl substituted amine with an itaconate, such as an N-substituted 4-carboxypyrrolidin-2-one, and methods of employing the same in lubricating compositions. The lubricating compositions containing the N-substituted 4-carboxypyrrolidin-2-one are preferably intended to be employed in a method for lubricating a mechanical device, such as an automatic or manual transmission. However, it is envisioned that the compound can be employed in engine oil lubricants and any other type of functional fluid.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: November 1, 2016
    Assignee: The Lubrizol Corporation
    Inventors: Daniel J. Saccomando, Richard J. Vickerman, Yanshi Zhang
  • Patent number: 9474295
    Abstract: A method of purifying a Luo Han Guo extract includes contacting the Luo Han Guo extract with activated carbon and a macroporous polymeric adsorbent resin, an ion exchange resin, or both.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: October 25, 2016
    Assignee: Tate & Lyle Ingredients Americas LLC
    Inventors: Brian Timothy Pohrte, Timothy C. Schunk, Elber F. Tejada
  • Patent number: 9468592
    Abstract: Described herein are toothpaste compositions comprising an orally acceptable vehicle; calcium carbonate; and a binder system comprising guar gum and at least one cellulose polymer.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: October 18, 2016
    Assignee: Colgate-Palmolive Company
    Inventors: Rolando Plata, Xiaojing Lu, Yuyan Zeng, Chengkang Tan