Derived From Musculoskeletal System, Other Than Cardiac Muscle (e.g., Cartilage, Muscle, Etc.) Patents (Class 424/548)
  • Patent number: 10376566
    Abstract: An intervention for sleep disorders comprises: collagen, a gelatin peptide, or the amino acid glycine; L-theanine; lactucopicrin, deoxylactucopicrin, or another lactucopicrin derivative; hyaluronic acid; epigallocatechin gallate; and quinic acid. The intervention helps regulate pro-inflammatory biomarkers that are often associated with insomnia development and progression. These biomarkers include cytokines and enzymes associated with tryptophan degradation. Inhibition of these enzymes and cytokines improves tryptophan availability and sleep quality, and allows individuals to sleep better with fewer side effects. The composition promotes high-quality, deep sleep.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: August 13, 2019
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Jack N. Losso, Jose Daniel Estrada Andino
  • Patent number: 10357590
    Abstract: The present disclosure is directed to a bioresorbable ceramic composition having a plurality of biocompatible ceramic granules, each of the granules having a coating of a plurality of calcium containing particles, where at least a portion of the particles are bound to at least a portion of an outer surface of each of the granules, and further where the composition is flowable in a dry state. The present disclosure is also directed to a three dimensional scaffold for bone repair that includes the bioresorbable composition, which upon implantation to a locus of repair defines an interconnected pore network between outer walls of the coated granules of the composition. Finally, the present disclosure is directed to methods of forming both the bioresorbable ceramic composition and the three-dimensional ceramic scaffold.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: July 23, 2019
    Assignee: DEPUY SYNTHES PRODUCTS, INC.
    Inventors: Xinyin Liu, Mark Fulmer, Peter Schaut, Kevin Joye
  • Patent number: 9675733
    Abstract: Disclosed herein, in certain instances, are methods of inhibiting osteoclast differentiation, bone resorption, bone formation, and bone remodeling in an individual in need thereof, comprising administering to the individual a composition comprising substantially fetal support tissue product including amniotic membrane and umbilical cord or an extract thereof, or a composition comprising substantially isolated HC-HA complex.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: June 13, 2017
    Assignee: TISSUETECH, INC.
    Inventors: Scheffer Tseng, Ek Kia Tan, Hua He
  • Patent number: 9549943
    Abstract: The present disclosure provides an A3 adenosine receptor (A3AR) ligand for the treatment of sexual dysfunction. In some embodiments the A3AR ligand is selected from an A3AR agonist and A3AR allosteric enhancer. The present disclosure also provides a method a method and pharmaceutical composition for treating a sexual dysfunction, the method comprises administering to a subject having the sexual dysfunction an amount of an A3 adenosine receptor (A3AR) ligand. In some embodiments, the A3AR ligand is an A3AR agonist and more specifically, IB-MECA.
    Type: Grant
    Filed: August 8, 2013
    Date of Patent: January 24, 2017
    Assignee: CAN-FITE BIOPHARMA LTD.
    Inventor: Pnina Fishman
  • Patent number: 9499791
    Abstract: The present invention provides muscle-derived progenitor cells (MDCs) that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction into a site of soft tissue. Also provided are methods of isolating MDCs. The invention further provides methods of using compositions comprising MDCs for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. The invention also relates to uses of MDCs for the treatment of cosmetic or functional conditions, including, but not limited to skeletal muscle weakness, muscular dystrophy, muscle atrophy, spasticity, myoclonus and myalgia. The invention also relates to the use of MDCs for the increase of skeletal muscle.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: November 22, 2016
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Thomas Payne, Ronald Jankowski, Ryan Pruchnic, Michael Chancellor
  • Patent number: 9402881
    Abstract: This invention provides methods for extracting platelets, compositions obtained therefore, and methods for using the same.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: August 2, 2016
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventor: Mark T. Roedersheimer
  • Patent number: 9347081
    Abstract: The present invention relates to a method for preparing a cartilage product comprising a protein hydrolysate with a degree of hydrolysis comprised between 0.5% and 3.0%, at least one glycosaminoglycan and at least one growth factor. The present invention also relates to the cartilage product obtainable through said method. Said cartilage product is useful in the treatment or prevention of wounds, ulcers, burns, psoriasis, osteoarthritis, synovitis, osteoporosis, osteopenia, diseases of the tendons and ligaments, periodontal diseases, signs of skin aging, the harmful effects of ultraviolet radiation exposure or stretch marks.
    Type: Grant
    Filed: April 16, 2012
    Date of Patent: May 24, 2016
    Assignee: BIOIBERICA, S.A.
    Inventors: Josep Escaich Ferrer, Pere Dalmau Castanares, Ana Maria Torrent Gibert, Ramon Ruhi Roura, Carlos Raul Alaez Verson
  • Patent number: 9284359
    Abstract: An object of the present invention is to efficiently extract proteoglycan from aquatic animal tissues. The method of the present invention is a method for extracting proteoglycan from fish cartilage, comprising the step of (A) heating small pieces of frozen fish cartilage in water. This method of the present invention enables easy extraction of proteoglycan from fish cartilage with very high efficiency. In particular, the method of the present invention enables extraction of high-molecular-weight proteoglycan. Further, since in the method of the present invention, extraction is performed using only water, it ensures safety in the extraction and safety of the resulting proteoglycan product, compared with hitherto known extraction methods using organic solvents or acids/alkali. Furthermore, the cumbersome step of removing organic solvents is not necessary in the method of the present invention.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: March 15, 2016
    Assignee: Hirosaki University
    Inventor: Yoji Kato
  • Publication number: 20150147407
    Abstract: An object of the present invention is to provide a means for preventing or treating osteoarthritis. The present invention provides a composition for preventing or treating osteoarthritis, comprising a fish cartilage water extract containing proteoglycans having molecular weights of not less than 1,800,000.
    Type: Application
    Filed: July 25, 2013
    Publication date: May 28, 2015
    Inventors: Yoji Kato, Shigeyuki Wakitani, Yukako Hanada, Kazushi Yamamoto
  • Publication number: 20150140057
    Abstract: This invention provides porated cartilage products, methods of producing porated cartilage products, and methods of treating subjects by administering cartilage products. Optionally, the cartilage products are sized, porated, and digested to provide a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.
    Type: Application
    Filed: August 20, 2014
    Publication date: May 21, 2015
    Inventors: Dana Sue Yoo, Jin-Qiang Kuang, Jaime Paden, Scott A. Maxson, Alla Danilkovitch, Erasmo Lopez, Samson Tom
  • Patent number: 9017711
    Abstract: Compositions and methods for treating and healing injured soft tissues such as tendons and ligaments are provided. The composition may be a wrap comprising human collagen in the form of a sheet. The human collagen has been processed so that is retains proteins that are associated with it in its natural state. The sheet may optionally be coated on one or more sides with one or more of additional human collagen, therapeutic agents, additional soft tissue growth factors or hydroxyapatite.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: April 28, 2015
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Nels J. Lauritzen, Abdulhafez A. Selem, Lawrence A. Shimp, Hsiu Ying Sherry Wang
  • Publication number: 20150072018
    Abstract: Products, processes, compositions, kits, and methods are provided for cartilage-derived implants. The implants can exhibit resistance to enzyme (e.g., collagenase, protease, etc.) digestion compared to the source tissue from which they were derived while still having one or more mechanical properties comparable to the source tissue from which they were derived. The implants can also have a plurality of molecular bridges between molecules of the cartilaginous material. The molecular bridges can connect one or more collagen fibrils and/or/with one or more glycosaminoglycans. The implants can also be treated with cationic detergent, packaged and sterilized with or without additional components, and surgically implanted into subjects.
    Type: Application
    Filed: September 4, 2014
    Publication date: March 12, 2015
    Inventor: Eran Rosines
  • Publication number: 20150010643
    Abstract: This invention relates to a method of treating B cell malignancies, which involves administering to a subject a compound having a structure of formula (I) to cause cell death of a B cell malignancy, thereby treating the B cell malignancy in the subject. Also disclosed are a method of causing cell death of malignant B cells, pharmaceutical compositions and therapeutic systems comprising a compound having a structure of formula (I), and a compound having a structure of formula (I).
    Type: Application
    Filed: February 15, 2013
    Publication date: January 8, 2015
    Applicant: UNIVERSITY OF ROCHESTER
    Inventor: Jiyong Zhao
  • Publication number: 20140356449
    Abstract: A method for treating a sore throat involves administering to a human subject in need of treatment of at least one of cartilage and a material derived from cartilage in a vehicle or composition that promotes or facilitates prolonged or extended contact of a sore throat with at least one of cartilage and a material derived from cartilage to reduce or eliminate the symptoms of a sore throat, typically within hours. The cartilage or materials derived from cartilage can be administered in a powdered form that is dispersed in a beverage, a syrup or a lozenge.
    Type: Application
    Filed: May 30, 2014
    Publication date: December 4, 2014
    Inventor: Edward Babinski
  • Publication number: 20140350677
    Abstract: One aspect of the present invention is a method of producing a decellularized composite tissue bioscaffold for musculoskeletal tissue interface reconstruction by physicochemically treating a musculoskeletal tissue interface isolated from allogeneic sources. In certain embodiments, such musculoskeletal tissue interfaces can also be isolated from xenogeneic sources. The method comprises treatment of the interface with detergents, chemical oxidants and ultrasonic energy, and wash steps in between to remove residual detergents as well as oxidants. The resulting bioscaffold may be freeze-dried or lyophilized, sterilized and aseptically packaged for subsequent use.
    Type: Application
    Filed: December 7, 2012
    Publication date: November 27, 2014
    Inventors: James Chang, Colin Woon, Hung Pham
  • Patent number: 8852580
    Abstract: An implant for repair of a cartilaginous defect in a subject includes a collagen matrix charged with synovial cells. A method preparing an implant for repair of a cartilaginous defect in a subject includes obtaining a fluid containing synovial cells and charging the synovial cells to the matrix. A device for preparing a cell-charged implant includes a first chamber and a second chamber, the first and second chambers being separated by a membrane and a perforated filter. The membrane is adapted to collect cells from a cell-containing fluid introduced into the first chamber and the perforated filter is adapted to permit passage or diffusion of the fluid through the second chamber. A method for preparing a cell-charged implant utilizes the device.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: October 7, 2014
    Assignee: Geistlich Pharma AG
    Inventors: Birgit Schaefer, Lothar Schloesser
  • Publication number: 20140294911
    Abstract: Cartilage materials such as cartilage fluff and a cartilage composition comprising a particulate material are disclosed. These are suitable for stimulating chondrogenesis and/or producing cartilage regeneration. Also disclosed are processes for their preparation. Methods for regenerating articular cartilage are also disclosed, which involve, for example, placing the cartilage fluff or cartilage composition into a cartilage defect.
    Type: Application
    Filed: June 5, 2014
    Publication date: October 2, 2014
    Applicant: Vivex Biomedical Inc.
    Inventor: Theodore I. Malinin
  • Publication number: 20140242125
    Abstract: The invention is directed to methods and compositions for obtaining uniform sized muscle fiber fragments for transplantation. These muscle fiber fragments are able to reconstitute into long fibers that are oriented along native muscle. The implanted muscle cells integrate with native vascular and neural network, as confirmed by histology and immunohistochemistry. This invention is particularly advantageous because autologous muscle can be harvested from a donor site, processed and injected into target sites in the operating room. The fragmented muscle fibers can be readily integrated within the host.
    Type: Application
    Filed: August 15, 2012
    Publication date: August 28, 2014
    Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
    Inventors: Anthony Atala, James Yoo, In Kap Ko
  • Publication number: 20140220096
    Abstract: Cartilage materials such as cartilage fluff and a cartilage composition comprising a particulate material are disclosed. These are suitable for stimulating chondrogenesis and/or producing cartilage regeneration. Also disclosed are processes for their preparation. Methods for regenerating articular cartilage are also disclosed, which involve, for example, placing the cartilage fluff or cartilage composition into a cartilage defect.
    Type: Application
    Filed: April 7, 2014
    Publication date: August 7, 2014
    Applicant: VIVEX BIOMEDICAL INC.
    Inventor: Theodore I. Malinin
  • Patent number: 8784800
    Abstract: A method of delivering therapy to a target site. The method includes (a) obtaining a base image of the target site, (b) injecting a dose of a mix of a therapeutic agent and a contrast agent into a first injection location at the target site via a needle passing through a catheter, (c) collecting sequential fluoroscopic images of a contrast agent dispersion cloud at the first injection location, (d) determining a contrast agent dispersion area from the sequential fluoroscopic images, (e) determining a therapeutic agent dispersion area from the contrast agent dispersion area, (f) marking the therapeutic agent dispersion area on the base image of the target site, and (g) repeating (b) through (f) until the target site is substantially covered with overlapping therapeutic agent dispersion areas corresponding to a plurality of injections at a plurality of injection locations at the target site.
    Type: Grant
    Filed: March 9, 2009
    Date of Patent: July 22, 2014
    Assignee: Medtronic, Inc.
    Inventors: Mary M. Morris, Kenneth Gardeski, Laurent Verard, Kevin Thomas Wu, Michael R. Neidert
  • Publication number: 20140199408
    Abstract: The present invention relates to a composition and uses thereof for treatment of damaged tissue comprising at least one essential amino acid in L form and at least one essential lipid; wherein the composition is administered to a mammal suffering from severe tissue damage. The invention further relates to a composition and uses thereof comprising the mixture of one or more free L-amino acids in which the molar ratio of the free L-amino acids corresponds to the molar ratio of amino components in a mammalian tissue protein; and at least one essential lipid.
    Type: Application
    Filed: March 17, 2014
    Publication date: July 17, 2014
    Applicant: Immunopath Profile, Inc.
    Inventor: LEONARD S. GIRSH
  • Publication number: 20140193368
    Abstract: Synthetic Stem Cell-like Tissue Healing and Regeneration Medication with Anti-inflammatory, Protein Synthesis, Enzyme Deficiency Activation and Genetic Therapy, and Anti-cancer Agent derived from a series of inventions that include these products of Biomolecular Engineering, Drug Discovery from a Biologic Periodic Table of Applied Biochemistry and Biophysics. Tissue has a self healing effect promoting tissue healing and tissue regeneration. Not only does it maintain good health but also it has been observed that the patient's blood is withdrawn from the patient and applied to the ulcer has healing qualities. Cartilage placed in a wound promotes and accelerates wound healing. The anabolic biochemical and biophysical equivalent of tissue has been found in these embodiments to have the same pharmacologic qualities, when devoid of genetic DNA mismatch and other catabolic factors including the catabolic effects of microorganism overgrowth that lacks pro-biotic qualities.
    Type: Application
    Filed: July 10, 2013
    Publication date: July 10, 2014
    Applicant: Immunopath Profile, Inc.
    Inventor: LEONARD S. GIRSH
  • Publication number: 20140178450
    Abstract: Described herein are compositions comprising decellularized extracellular matrix derived from skeletal muscle or other suitable tissue, and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, damage, ischemic, ulcer cells, tissues or organs in a subject preferably a human, with diseases, such as PAD and CLI, using a decellularized extracellular matrix of the invention are provided. Methods of preparing culture surfaces and culturing cells with absorbed decellularized extracellular matrix are provided.
    Type: Application
    Filed: February 28, 2014
    Publication date: June 26, 2014
    Applicant: The Regents of the University of California
    Inventors: Karen Christman, Jessica DeQuach
  • Publication number: 20140178343
    Abstract: The present disclosure provides tissue supports and methods for preparing a cartilage composition for repairing cartilage defects, which is prepared by expanding and integrating small cartilage tissue pieces derived from donor or engineered tissue. The methods and supports described herein promote cell migration and integration of neighboring tissue pieces in culture to form the cartilage composition. Methods of cartilage repair using the cartilage composition are also described.
    Type: Application
    Filed: March 13, 2013
    Publication date: June 26, 2014
    Inventors: Jian Q. Yao, Hali Wang
  • Patent number: 8753689
    Abstract: Demineralized bone particles are obtained by demineralizing whole bone and thereafter subdividing the demineralized bone to provide the demineralized bone particles.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: June 17, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: John W. Morris, Lawrence A. Shimp, Kenneth C. Petersen, Albert Manrique, David Kaes, Nelson Scarborough, Michael Dowd
  • Publication number: 20140134212
    Abstract: Compositions comprising a plurality of cartilage particles from a human adult cadaveric donor, wherein the cartilage particles comprise viable chondrocytes, and a biocompatible carrier are provided. Methods of manufacturing cartilage compositions comprising a plurality of cartilage particles from a human adult cadaveric donor are also provided.
    Type: Application
    Filed: November 15, 2013
    Publication date: May 15, 2014
    Applicant: AlloSource
    Inventors: Yaling Shi, Carolyn Barrett, Peter Stevens
  • Publication number: 20140112890
    Abstract: The invention features the production of an amine-reactive proteoglycan, specifically chondroitin sulfate or hyaluronic acid. This material can be provided in powder (solid) or liquid form and combined with blood derivatives including serum, platelets, platelet rich plasma, bone marrow, or with other tissue products to form hydrogels. The properties (physical and biological) are different for each of these hydrogels and can be further manipulated by controlling the conditions under which the hydrogels are formed. Such properties include the biodegradability of the hydrogel, the compressibility, the adhesive strength, the presence of pharmaceutical agents or therapeutic cells, and resiliency.
    Type: Application
    Filed: April 2, 2012
    Publication date: April 24, 2014
    Applicant: The John Hopkins University
    Inventors: Jennifer H. Elisseeff, Iossif Strehin
  • Patent number: 8673362
    Abstract: The present invention relates to a composition and uses thereof for treatment of damaged tissue comprising at least one essential amino acid in L form and at least one essential lipid; wherein the composition is administered to a mammal suffering from severe tissue damage. The invention further relates to a composition and uses thereof comprising the mixture of one or more free L-amino acids in which the molar ratio of the free L-amino acids corresponds to the molar ratio of amino components in a mammalian tissue protein; and at least one essential lipid.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: March 18, 2014
    Assignee: Immunopath Profile, Inc.
    Inventor: Leonard S. Girsh
  • Publication number: 20140065238
    Abstract: The invention provides methodologies and apparatus for producing acellular soft-tissue implants, both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. An acellular graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, followed by inducing a pressure mediated flow of a treating solution, then washing the treated tissue to produce the acellular graft. The acellular grafts produced are uniform and nonimmunogenic. The inventive method allows for the production of multiple decellularized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes. In clinical use, the decellularized grafts produced exhibit significantly improved in long-tem durability and function.
    Type: Application
    Filed: October 31, 2013
    Publication date: March 6, 2014
    Applicant: LifeNet Health
    Inventors: Lloyd Wolfinbarger, JR., Peny Lange, Alyce Linthurst-Jones, Eric Moore, Barry Naif
  • Patent number: 8658218
    Abstract: A composition for treating damaged tissue and promoting healthy tissue growth, healing and tissue regeneration, wherein the composition comprises an extracellular matrix compound, a surface-active lipid, one or more enantiomericaily pure L-amino acids or glycine, a hydrophilic surfactant with a high HLB, as well as vitamins, minerals or trace elements. Not only does it maintain good health, but the components are non-intrusive, bio-safe, non-coalescent and can mimic normally occurring stem-cells within a body. When applied to diseased tissues, the subject compositions can stimulate, facilitate, and accelerate protein synthesis for the regeneration of diseased organs and tissues. The healing efficacy of these tissue components gives us further appreciation of the protective action of human tissue over and above and other than the immune protective system or perhaps an integral component part of the immune system.
    Type: Grant
    Filed: February 8, 2012
    Date of Patent: February 25, 2014
    Assignee: Immunopath Profile, Inc.
    Inventor: Leonard S. Girsh
  • Patent number: 8652530
    Abstract: The instant invention is the storage of Type II collagen containing tissue in carbonated water. Such Type II collagen is useful for alleviating the symptoms of arthritis in mammals as well as the treatment of arthritis in mammals. Such Type II collagen is also useful for the prevention of arthritis in mammals. The instant invention is also a method for the preparation of a nutritional supplement that includes the steps of: (a) separating water-insoluble undenatured Type II collagen containing animal tissue from animal tissue not containing Type II collagen; (b) subdividing and sterilizing said tissue under conditions which do not change the original structure of the Type II collagen to produce a subdivided and sterilized product; (c) packaging the subdivided and sterilized product in carbonated water.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: February 18, 2014
    Assignee: Cartilast Corp.
    Inventor: Eugene R. Moore
  • Publication number: 20140023687
    Abstract: A medical device, said medical device, comprises: a first component having a non-biological material; a second component having a cloned biological material, said second component being attached to said first component, wherein said first component and said second component are operatively associated in a non-living medical device for at least one of treatment, diagnosis, cure, mitigation and prevention of disease, injury, handicap or condition in a living organism. In another aspect, a method comprises: preparing a cloned biological material from a tissue or an organ; attaching said biological material to a medical device; interfacing said biological material with the non-biological material; providing treatment, diagnosis, cure, mitigation and prevention of disease, injury, handicap or condition in a living organism.
    Type: Application
    Filed: September 24, 2013
    Publication date: January 23, 2014
    Applicant: First Principles, Inc.
    Inventor: Keith A Raniere
  • Publication number: 20140017283
    Abstract: This invention provides porated cartilage products, methods of producing porated cartilage products, and methods of treating subjects by administering cartilage products. Optionally, the cartilage products are sized, porated, and digested to provide a flexible cartilage product. Optionally, the cartilage products comprise viable chondrocytes, bioactive factors such as chondrogenic factors, and a collagen type II matrix. Optionally, the cartilage products are non-immunogenic.
    Type: Application
    Filed: July 11, 2013
    Publication date: January 16, 2014
    Inventors: Dana Sue Yoo, Jin-Qiang Kuang, Jaime Paden, Scott A. Maxson, Alla Danilkovitch, Erasmo Lopez, Samson Tom
  • Publication number: 20130330391
    Abstract: Cartilage materials such as cartilage fluff and a cartilage composition comprising a particulate material are disclosed. These are suitable for stimulating chondrogenesis and/or producing cartilage regeneration. Also disclosed are processes for their preparation. Methods for regenerating articular cartilage are also disclosed, which involve, for example, placing the cartilage fluff or cartilage composition into a cartilage defect.
    Type: Application
    Filed: August 14, 2013
    Publication date: December 12, 2013
    Applicant: VIVEX BIOMEDICAL INC.
    Inventor: Theodore I. Malinin
  • Publication number: 20130302435
    Abstract: The present application is directed to the field of implants comprising soft tissue for use in implantation in humans. The soft tissue implants of the present application are preferably obtained from xenograft sources. The present application provides a chemical process that neutralizes, removes or substantially reduces antigens from and sterilizes and/or strengthens xenograft implants. The present techniques yield soft tissue implants having superior structural, mechanical, and/or biochemical integrity. The present application is also directed to processes for treating xenograft implants comprising soft tissues such as tendons and ligaments, and to implants produced by such processes.
    Type: Application
    Filed: March 14, 2013
    Publication date: November 14, 2013
    Inventors: Pedro Daniel Pedroso, Amanda Michele Ely
  • Publication number: 20130287859
    Abstract: Disclosed herein is a method of treating psoriatic pruritus by topical administration of a cartilage extract to the affected areas of a patient's skin and a topical composition for use in practicing the method.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 31, 2013
    Applicant: LESCARDEN INC.
    Inventors: Xavier Gras Balaguer, William Luther
  • Publication number: 20130287741
    Abstract: Flowable matrix compositions and methods of their use and manufacture are provided. Exemplary compositions may include a flowable, syringeable, putty-like form of acellular human dermal matrix. In some cases, compositions may include a moldable acellular collagen extracellular matrix. In use, the matrix compositions can be used to fill or treat skin voids, channel wounds, and other soft tissue deficiencies.
    Type: Application
    Filed: December 12, 2012
    Publication date: October 31, 2013
    Inventor: AlloSource
  • Publication number: 20130287695
    Abstract: Disclosed is a cell which enables the reproduction of a cartilage tissue and has a proliferative ability. Also disclosed is a technique for providing a cell supply source which can be used in a definitive treatment of osteochondrosis deformans. A chondrocyte-like cell which has the same properties as those of a chondrocyte and can proliferate can be produced by selecting a combination of an Myc family gene and/or a Klf family gene and a SOX9 gene and introducing the combination into a somatic cell. The chondrocyte-like cell can be used for a medical purpose of cartilage regeneration.
    Type: Application
    Filed: June 25, 2013
    Publication date: October 31, 2013
    Inventor: Noriyuki TSUMAKI
  • Publication number: 20130280343
    Abstract: A process, wherein food-producing livestock are administered cannabinoid receptor agonists, is used to induce physiological and/or behavioral effects in the livestock. Food products are then derived from the livestock.
    Type: Application
    Filed: April 20, 2012
    Publication date: October 24, 2013
    Inventor: Justin Lee Roettger
  • Patent number: 8563045
    Abstract: Hydrolyzed collagen type II powder compositions for inducing cartilage formation in an individual, method of preparing the compositions and use of the compositions in treating connective tissue disorder, replenishing skin viscoelasticity. The compositions are administered through an orally ingestible delivery medium for absorption into the gastrointestinal tract. The compositions are administered through a topical delivery medium for absorption into a dermis of the individual.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: October 22, 2013
    Assignee: Biocell Technology, LLC
    Inventor: Suhail Ishaq
  • Publication number: 20130251687
    Abstract: Described herein are compositions comprising decellularized cardiac extracellular matrix and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, damaged or ischemic cells, tissues or organs in a subject, preferably a human, using a decellularized cardiac extracellular matrix of the invention are provided. Methods of preparing cardiomyocyte culture surfaces and culturing cells with absorbed decellularized cardiac extracellular matrix are provided.
    Type: Application
    Filed: May 10, 2013
    Publication date: September 26, 2013
    Applicant: The Regents of the University of California
    Inventors: Karen Christman, Jennifer Singelyn, Jessica DeQuach
  • Publication number: 20130243738
    Abstract: The present invention relates to methods for removing antigens from tissues by sequentially destabilizing and/or depolymerizing cytoskeletal components and removing and/or reducing water-soluble antigens and lipid-soluble antigens. The invention further relates to tissue scaffolding and decellularized extracellular matrix produced by such methods.
    Type: Application
    Filed: March 11, 2013
    Publication date: September 19, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Leigh G. GRIFFITHS, Angeliki PAPALAMPROU, Maelene L. WONG
  • Publication number: 20130236453
    Abstract: Methods and compositions for treating or preventing acute graft-versus-host disease (aGVHD) in a subject using miR-155 specific inhibitors are described.
    Type: Application
    Filed: March 12, 2013
    Publication date: September 12, 2013
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, Ramiro Garzon
  • Patent number: 8529962
    Abstract: Demineralized bone particles are obtained by demineralizing whole bone and thereafter subdividing the demineralized bone to provide the demineralized bone particles.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: September 10, 2013
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: John W. Morris, Lawrence A. Shimp, Kenneth C. Petersen, Albert Manrique, David Kaes, Nelson Scarborough, Michael Dowd
  • Publication number: 20130203664
    Abstract: Nutritional compositions having reduced amounts of calories and high amounts of protein and methods of making and using the nutritional compositions are provided. The nutritional compositions may include a processed whole food component, a high amount of protein, and a reduced amount of calories in order to provide a patient with a pH-balanced formulation that includes the benefits of food bioactives beyond essential macro- and micronutrients without providing excessive energy. Methods of administering such nutritional compositions to patients in need of improved bone, muscle, neurological, immune, and/or overall health are also provided.
    Type: Application
    Filed: June 28, 2011
    Publication date: August 8, 2013
    Applicant: NESTEC S.A.
    Inventors: Doug Bolster, Zamzam Fariba Roughead, Norman Alan Greenberg, Jennifer Mager
  • Patent number: 8470522
    Abstract: Disclosed herein is a three-dimensional culture containing human articular chondrocytes with induced terminal differentiation changes, as well as a process for preparing the same. The three-dimensional culture, which was found to mimic the biological characteristics of articular chondrocytes that undergo terminal differentiation in vivo, can be used as a tool in the studies of the molecular and cellular mechanisms of osteoarthritis, and in the screening of candidate drugs for use in treatment of a disorder associated with articular chondrocytes.
    Type: Grant
    Filed: July 20, 2006
    Date of Patent: June 25, 2013
    Assignee: Kaohsiung Medical University
    Inventors: Mei-Ling Ho, Gwo-Jaw Wang, Je-Ken Chang
  • Patent number: 8455448
    Abstract: The present invention provides splice variants of myostatin that promote muscle growth, and include polynucleotides and polypeptide sequences, constructs comprising the sequences and compositions for regulating muscle growth and treating diseases associated with muscle tissue. The splice variants include the consensus sequence X1 I F L E X2 X3 X4 Q X5 C S I L X6 X7 X8 X9 X10 wherein X1 is I or L, X2 is V or L, X3 is Y, C, G or S, X4 is I or F, X5 is F or L, X6 is G or E, X7 is E or V, X8 is A or T, X9 is A or V and X10 is absent, F or L. The present invention also provides for the use of the present sequences in identifying animals with altered muscle mass, and for use in selective breeding programs to produce animals with altered muscle mass.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: June 4, 2013
    Assignee: Myostin Therapeutics Pty Ltd
    Inventors: Ferenc Jeanplong, Christopher David McMahon
  • Patent number: 8440618
    Abstract: The present invention relates to a novel composition comprising an implant, scaffold or construct bound to a biological or chemical moiety. The bound moiety has the ability to bind to a component of the extracellular matrix of biological tissue, allowing the implant to be bound to the biological tissue in a short period of time after implantation. The invention also relates to the use and manufacture of this novel composition, as well as a novel use for the protein CNA.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: May 14, 2013
    Assignees: New York Society for the Ruptured and Crippled Maintaining the Hospital for Special Surgery, The Trustees of Princeton University, The Texas A&M University System
    Inventors: Suzanne A. Maher, Jeffrey Schwartz, Axel Oscar Magnus Hook, Brooke Hageman Russell, Casey Marie Jones
  • Patent number: 8414928
    Abstract: A cartilage-like biomaterial is bioengineered by using a self-aggregating suspension cell culture with hydrostatic mechanical force without the use of a scaffold or foreign matrix for cell attachment during culture. The cells in suspension culture may be preconditioned prior to application of the hydrostatic mechanical force, such as hydrostatic pressure, for a period of time in the range of about 1 week to about 10 weeks. The cartilage-like biomaterial shares critical structural, phenotype, and functional characteristics with native, intact cartilage tissue.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: April 9, 2013
    Inventor: George R. Dodge
  • Publication number: 20130028981
    Abstract: A method for producing sterile, decellurized bioprosthetic tissue comprising: (a) contacting a human tissue with a hypotonic solution to produce a lysed tissue, (b) contacting the lysed tissue with a first surfactant to produce a surfactant-treated tissue, (c) contacting the surfactant-treated tissue with a nuclease enzyme solution to produce an enzyme-treated tissue, (d) contacting the enzyme-treated tissue with a cleaning solution comprising a second surfactant, a chaotropic agent or a mixture thereof to produce a decellurized tissue and (e) contacting the decellurized tissue with a bioburden reducing agent to produce the final bioprosthetic tissue. Kits to be used in conjunction with said method, as well as, the bioprosthetic tissue produced via said method are also provided.
    Type: Application
    Filed: February 25, 2011
    Publication date: January 31, 2013
    Applicant: DECELL TECHNOLOGIES INC.
    Inventor: Paul F. Gratzer