Skeleton (e.g., Bone, Teeth, Etc.) Patents (Class 424/549)
  • Patent number: 10286104
    Abstract: A carbonate apatite prepared from natural bone. The carbonate apatite has a protein content of 2000-8000 parts per million and a surface area of 15 to 70 m2/g. Also provided is a method for preparing the carbonate apatite from cancellous bone particles.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: May 14, 2019
    Assignee: Collagen Matrix, Inc.
    Inventors: Shu-Tung Li, Hui-Chen Chen, Debbie Yuen
  • Patent number: 10201635
    Abstract: Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth. The compression resistant implant comprises a biodegradable polymer in an amount of about 0.1 wt % to about 20 wt % of the implant and a freeze-dried oxysterol in an amount of about 5 wt % to about 90 wt % of the implant. Methods of making and use are further provided.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: February 12, 2019
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Benjamin T. Reves, David S. Scher, Roger E. Harrington, Jerbrena C. Jacobs
  • Patent number: 10130736
    Abstract: The disclosure provides implants containing a plurality of particles containing at least one population of viable osteogenic cells adherent to and resident in an osteoconductive matrix or at least one viable population of osteogenic cells caused to be in contact with the osteoconductive matrix; methods of fabricating the implants; and use of the implants in bone repair. The implant further contains an osteoinductive component. An example of an osteoinductive component is a demineralized bone matrix in the form of particles or fibers.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: November 20, 2018
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Eric Semler, Alex Callahan, Joed Canales, Katrina Carroll, Anouska Dasgupta, Roman Shikhanovich
  • Patent number: 9968704
    Abstract: A method for regenerating alveolar bone in which bone tissue is regenerated in the gap between an implant or dental root and alveolar bone, which comprises a procedure consisting of making an incision in the gingiva surrounding an implant or dental root embedded in alveolar bone, blowing a first air into the gap between the implant or dental root and the alveolar bone to remove a portion of infected granulation tissue present in the gap, and irradiating the gap with laser light to degenerate the infected granulation tissue remaining in the gap, followed by blowing a second air containing microparticles having calcium as a constituent thereof and water into the gap to remove the degenerated infected granulation tissue and fill in the gap with the wet microparticles.
    Type: Grant
    Filed: April 19, 2012
    Date of Patent: May 15, 2018
    Assignee: BIO MAP CO., LTD.
    Inventors: Naoko Kajimoto, Kyousuke Kajimoto, Tadamori Kajimoto
  • Patent number: 9789190
    Abstract: Enamel Matrix Derivative (EMD) proteins and enamel matrix proteins are widely used in clinical dentistry because of their ability to promote regeneration of soft and hard tissues and to reduce inflammation and infections. The present invention relates to the surprising finding that a pharmaceutical, dental and/or cosmetic formulation, which comprises purified Enamel Matrix Derivative (EMD) proteins and/or enamel matrix proteins and sterilized Propylene Glycol Alginate (PGA), wherein the sterilized PGA is obtained from non-sterilized PGA having a weight average molecular weight (Mwo) of between 250-500 kDa, is more stable over time, especially, the pH is more stable over time.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: October 17, 2017
    Assignee: STRAUMANN HOLDING AG
    Inventors: Laszlo Garamszegi, Andri Vital
  • Patent number: 9687511
    Abstract: A biological composition has a mixture of mechanically selected allogeneic biologic material derived from bone marrow. The mixture has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components. The mixture including non-whole cell fractions including one or more of exosomes, transcriptosomes, proteasomes, membrane rafts, lipid rafts. The mixture is compatible with biologic function.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: June 27, 2017
    Assignee: Vivex Biomedical, Inc.
    Inventors: Wendy W. Weston, Miguel Quevedo, Stuart Oglesby, Gaëtan Jean-Robert Delcroix, Paul C. Schiller, Gianluca D'Ippolito, Timothy Ganey
  • Patent number: 9585764
    Abstract: An osteoimplant device is provided. The osteoimplant device includes a body of nondemineralized cortical bone and an outer surface having at least one region including demineralized bone. The osteoimplant device is formable into a shape and size configured for implantation at a surgical site. A disc shaped osteoimplant can be used for a facet joint fusion. A method of treating a patient having a bone defect in a host bone is also provided, the method including inserting the osteoimplant into the bone defect, for example, one associated with a facet joint.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: March 7, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Patent number: 9339589
    Abstract: The invention is directed to an apparatus for producing demineralized osteoinductive bone. The apparatus demineralizes bone by subjecting bone, including, for example, ground bone, bone cubes, chips, strips, or essentially intact bone, to either a rapid high volume pulsatile acidification wave process or to a rapid continuous acid demineralization process. The pulsatile acidification wave process includes subjecting bone to two or more rapid pulse/drain cycles in which one or more demineralizing acids is rapidly pulsed into a vessel containing bone, and after a desired period of time, is rapidly drained from the vessel. The continuous acid demineralization process includes subjecting bone to a continuous exchange of demineralizing acid solution in which the demineralizing acid solution is recirculated from the container holding the bone through an ion exchange media.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: May 17, 2016
    Assignee: LifeNet Health
    Inventors: Debra Moore-Smith, Robert K. O'Leary, Anne Wilson
  • Patent number: 9198884
    Abstract: Carboxymethylcellulose, notably sodium carboxymethylcellulose or other alkali metal or alkaline earth metal salts of carboxymethylcellulose, are employed to control solidification time of compositions comprising one or more bioresorbable ceramics, notably a hydratable calcium sulphate, in order to facilitate preparation of a ready-to-use composition for inserting into the body by injection.
    Type: Grant
    Filed: November 27, 2009
    Date of Patent: December 1, 2015
    Assignee: LIDDS AB
    Inventors: Lars Åke Malmsten, Niklas Axén, Hans Lennernäs, Anders Carlsson
  • Publication number: 20150147397
    Abstract: This invention is directed to aragonite and calcite hydrogel biomatrices, optionally seeded with precursor cells and uses thereof in tissue engineering, regeneration and repair, including in inducing or enhancing bone formation, cartilage formation or a combination thereof in a subject, and kits related thereto.
    Type: Application
    Filed: April 29, 2013
    Publication date: May 28, 2015
    Inventor: Nir Altschuler
  • Publication number: 20150147408
    Abstract: A Method Validation Unit (MVU) for the evaluation of the level of sterilisation in a sterilisation method involving the use of a fluid at or near the supercritical pressure and temperature for that fluid, wherein the MVU comprises a sterilisation indicator housed within a gas-permeable container, wherein the sterilisation indicator comprises an indicator medium and a population of one or more colony forming units (CFUs), and wherein the indicator medium comprises one or more structural features representative of the internal structure of a material to be sterilised in the sterilisation method.
    Type: Application
    Filed: May 30, 2013
    Publication date: May 28, 2015
    Applicant: Austrialian Biotechnologies PTY. Limited
    Inventors: Simon Jonothan Berry, Sharon Bryce, Jerome Alon Goldberg
  • Publication number: 20150140115
    Abstract: The present invention relates to oriental medicine compositions marked as SEC 22 and SEC 33 for improving digestive functions and respiratory functions for improving children's underweight, low growth and depressed respiratory organ, an oriental medicine derived therefrom, and methods of preparing them. According to an example of the present invention, the oriental medicine composition containing broiled fruit of Crataegus pinnatifida, broiled root of Atractylodes japonica, dried peel of Citrus unshiu, broiled sprout of Hordeum vulgare, broiled fruit of Amomum xanthioides, root of Zingiber officinale, dried fruit of Zizyphi, and horn of Cervus elaphus.
    Type: Application
    Filed: November 19, 2014
    Publication date: May 21, 2015
    Inventor: Ki Joon Kim
  • Publication number: 20150140116
    Abstract: The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices. The intrinsic bioactivity of the hydrogel matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implanted device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissue bulking.
    Type: Application
    Filed: January 30, 2015
    Publication date: May 21, 2015
    Inventors: Francis Vincent Lamberti, Richard Chris Klann, Ronald Stewart Hill
  • Publication number: 20150118160
    Abstract: A composition of a bone repair mixture has a quantity of allograft particulate bone having a bone particle distribution of particle sizes less than 700 micron and a quantity of biologic carrier material intermixed with the particulate bone. The biologic carrier material is one of fascia, deep fascia or a fascia mixture. Preferably, the carrier material is exclusively fascia lata.
    Type: Application
    Filed: January 6, 2015
    Publication date: April 30, 2015
    Applicant: VIVEX BIOMEDICAL INC.
    Inventors: Tracy Scott Anderson, Timothy E. Taylor
  • Patent number: 9017711
    Abstract: Compositions and methods for treating and healing injured soft tissues such as tendons and ligaments are provided. The composition may be a wrap comprising human collagen in the form of a sheet. The human collagen has been processed so that is retains proteins that are associated with it in its natural state. The sheet may optionally be coated on one or more sides with one or more of additional human collagen, therapeutic agents, additional soft tissue growth factors or hydroxyapatite.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: April 28, 2015
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Nels J. Lauritzen, Abdulhafez A. Selem, Lawrence A. Shimp, Hsiu Ying Sherry Wang
  • Publication number: 20150110890
    Abstract: A method of preparing a bone graft. Mixing bone marrow aspirate with an effective amount of a binding reagent that is capable of binding with red blood cells in the bone marrow aspirate. The bound red blood cells are aggregated. The aggregated bound red blood cells are separated from the bone marrow aspirate to provide a supernatant. At least a portion of the supernatant is associated with an osteoconductive matrix to form the bone graft.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Inventor: Robert Assell
  • Publication number: 20150110891
    Abstract: The subject of the present invention is a bioactive cell homogenate produced from cells belonging to the MIC-1 stem cell line derived from growing deer antlers (Cervidae) deposited at the DSMZ under the accession DSM ACC2854, a method of producing and using it. The present invention also encompasses a pharmaceutical or cosmetic composition containing the above-mentioned homogenate.
    Type: Application
    Filed: October 29, 2014
    Publication date: April 23, 2015
    Applicant: STEM CELLS SPIN S.A.
    Inventors: Wojciech DZIEWISZEK, Marek CEGIELSKI, Marek BOCHNIA
  • Patent number: 9011930
    Abstract: Nutritional supplements and methods for maintaining and/or improving the condition of bones or cartilage in a mammal, particularly a human. One such supplement comprises demineralized bone matrix (DBM) wherein the DBM comprises a bone growth improving amount of at least one osteoinductive growth factor. A preferred supplement composition further comprises at least one vitamin, such as vitamin E. One method comprises orally administering to the mammal on a periodic basis a supplement comprising DBM. In a preferred method the DBM composition is periodically administered and there is a further periodic administration of a therapeutically effective amount of a calcium-containing composition; the calcium-containing composition is administered temporally spaced apart from said DBM composition for maximum effectiveness.
    Type: Grant
    Filed: May 1, 2006
    Date of Patent: April 21, 2015
    Assignee: ZyCal Bioceuticals Healthcare Company, Inc.
    Inventor: James Scaffidi
  • Publication number: 20150093429
    Abstract: A bone repair composition and methods thereof include elongated bone fibers made from cortical bone in which a plurality of approximately uniform bone fibers is made into various implant shapes conducive for various applications. The bone fiber compositions may be in the form of a cavity, ball, pellet, wrap, strip, cylinder, cone, putty, gel, or injectable slurry.
    Type: Application
    Filed: December 11, 2014
    Publication date: April 2, 2015
    Applicant: THERACELL, INC.
    Inventors: Andrew J. Carter, Nelson L. Scarborough, Bradley Patt
  • Patent number: 8992965
    Abstract: An osteoinductive composition, corresponding osteoimplants, and methods for making the osteoinductive composition are disclosed. The osteoinductive composition comprises osteoinductive factors, such as may be extracted from demineralized bone, and a carrier. The osteoinductive composition is prepared by providing demineralized bone, extracting osteoinductive factors from the demineralized bone, and adding the extracted osteoinductive factors to a carrier. Further additives such as bioactive agents may be added to the osteoinductive composition. The carrier and osteoinductive factors may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, can induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. Also, in some embodiments, the osteoinductive composition can be used as a delivery device to administer bioactive agents.
    Type: Grant
    Filed: November 1, 2006
    Date of Patent: March 31, 2015
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: Keyvan Behnam
  • Patent number: 8992964
    Abstract: A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: March 31, 2015
    Assignee: Bacterin International, Inc.
    Inventors: Nancy J. Shelby, Steven M. Scott, Benjamin P. Luchsinger, Gregory A. Juda, Kelly R. Kirker, Jesus Hernandez, Darrel L. Holmes
  • Patent number: 8980328
    Abstract: A method for preparing carbonate apatite from natural bones. The method includes obtaining cancellous bone particles; treating the bone particles with hot water and an organic solvent; repeating the treating step at least once; drying the bone particles; and heating the bone particles at 500° C. to 620° C. for 10 to 50 hours.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: March 17, 2015
    Assignee: Collagen Matrix, Inc.
    Inventors: Shu-Tung Li, Hui-Chen Chen, Debbie Yuen
  • Publication number: 20150050358
    Abstract: This disclosure describes an implant support composition and methods of using the implant support composition. Generally, the implant support composition includes a filler, an osteoconductive material, an osteoinductive material, and an antimicrobial agent.
    Type: Application
    Filed: August 14, 2014
    Publication date: February 19, 2015
    Inventors: Wook-Jin Seong, James Edward Hinrichs, Robert Joseph Schumacher
  • Publication number: 20150037432
    Abstract: The present invention is a composition of a self-assembly of collagen fibers made from a plurality of sized pieces of a source material. The source material made from animal or human tissue selected from one of dermis, tendon, fascia or dura mater. The self-assembly occurring by induction of a magnetic field in a liquid medium.
    Type: Application
    Filed: July 31, 2013
    Publication date: February 5, 2015
    Applicant: VIVEX BIOMEDICAL INC.
    Inventor: Theodore I. Malinin
  • Publication number: 20150030660
    Abstract: A structure of, and a method of producing, a biocompatible structure for bone and tissue regeneration are disclosed. The method includes dissolving a polyurethane polymer in methanol, adding hydroxyapatite (HAP) nanoparticles to form a uniformly distributed mixture, applying the mixture to a polytetrafluoroethylene (PTFE) surface to form a polymer film, cutting the polymer film into strips, stacking the strips with layers of bone particles disposed therebetween, coating the stacked strips and layers by the mixture and allowing it to dry, adding bone particles to the coating, and plasma treating the structure to form the biocompatible structure. A weight percentage of the HAP nanoparticles to the polymer is about 5-50% such that a resorption rate of the biocompatible structure substantially matches a rate of tissue generation in the biocompatible structure.
    Type: Application
    Filed: October 3, 2014
    Publication date: January 29, 2015
    Inventor: Alexandru S. Biris
  • Publication number: 20150010510
    Abstract: Methods of manufacturing a bone-derived extracellular matrix (bECM) product are provided. Also provided are bECM products and methods of using those products.
    Type: Application
    Filed: July 3, 2014
    Publication date: January 8, 2015
    Inventors: Stephen F. Badylak, Michael J. Sawkins, Kevin M. Shakesheff, Lisa J. White
  • Publication number: 20150010642
    Abstract: A composition of a bone repair mixture has a quantity of allograft particulate bone having a bone particle distribution of particle sizes less than 700 micron and a quantity of biologic carrier material intermixed with the particulate bone. The biologic carrier material is one of collagen, porous collagen or a collagen mixture. Preferably, the carrier material is exclusively collagen.
    Type: Application
    Filed: June 10, 2014
    Publication date: January 8, 2015
    Applicant: Vivex Biomedical, Inc.
    Inventors: Tracy Scott Anderson, Timothy E. Taylor
  • Publication number: 20150011947
    Abstract: A composition of a bone repair mixture has a quantity of allograft particulate bone having a bone particle distribution of particle sizes less than 700 micron and a quantity of biologic carrier material intermixed with the particulate bone. The biologic carrier material is one of fascia, deep fascia or a fascia mixture. Preferably, the carrier material is exclusively fascia lata.
    Type: Application
    Filed: December 19, 2013
    Publication date: January 8, 2015
    Applicant: VIVEX BIOMEDICAL INC.
    Inventors: Tracy Scott Anderson, Timothy E. Taylor
  • Publication number: 20150010607
    Abstract: The invention relates to methods of preparing a bone matrix solution, a bone matrix implant, and variants thereof. The invention also relates to methods of cell culture using the same. The invention further relates to bone matrix scaffolds comprising one or more bone matrix nanofibers, methods of preparing, and methods of use thereof. The invention also relates to methods of culturing cells and promoting differentiation of stem cells using the same.
    Type: Application
    Filed: February 7, 2013
    Publication date: January 8, 2015
    Inventors: Michael Francis, Roy Ogle
  • Patent number: 8926710
    Abstract: Osteoconductive bone graft materials are provided. These compositions contain injectable cements and demineralized bone matrix fibers. The combination of these materials enables the filling of a bone void while balancing strength and resorption.
    Type: Grant
    Filed: October 25, 2010
    Date of Patent: January 6, 2015
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Publication number: 20150004247
    Abstract: An improved composition for inducing bone growth is provided that is a mixture of DBM and a perfluorocarbon oxygen carrier. Injection/implantation of a composition of DBM and a perfluorocarbon results in enhancement of bone formation.
    Type: Application
    Filed: September 12, 2014
    Publication date: January 1, 2015
    Inventors: Andrew J. Carter, Nelson L. Scarborough, Richard K. Grant, Frank M. Phillips, Stephen H. Hochschuler
  • Publication number: 20140342013
    Abstract: Calcium phosphate cement compositions are provided. Aspects of the cement compositions include a dry reactant component comprising a reactive ?-tricalcium phosphate component, a multi-size pore forming calcium sulphate dihydrate component and a demineralized bone matrix component. During use, the dry reactant is combined with a setting fluid to produce a sellable composition that sets into a high strength porous product. Aspects of the invention further include the settable compositions themselves as well as kits for preparing the same. Methods and compositions as described herein find use in a variety of applications, including hard tissue repair applications.
    Type: Application
    Filed: March 14, 2014
    Publication date: November 20, 2014
    Inventors: Jiawei He, David C. Delaney
  • Publication number: 20140335197
    Abstract: The invention relates to a synthetic bone material and a process for making the same. The synthetic bone material may comprise multiple phases of calcium phosphate. Another aspect of the invention is a porous filter, and the method of making the same, and wherein the porous filter is substantially similar to the process for forming the synthetic bone material.
    Type: Application
    Filed: May 12, 2014
    Publication date: November 13, 2014
    Inventors: Reed A. Ayers, Nina L. Vollmer
  • Publication number: 20140314822
    Abstract: A bone repair composition and methods thereof include elongated bone fibers made from cortical bone in which a plurality of approximately uniform bone fibers is made into various implant shapes conducive for various applications. The bone fiber compositions may be in the form of a cavity, ball, pellet, wrap, strip, cylinder, cone, putty, gel, or injectable slurry.
    Type: Application
    Filed: April 18, 2014
    Publication date: October 23, 2014
    Inventors: Andrew J. Carter, Nelson L. Scarborough, Bradley Patt
  • Patent number: 8859007
    Abstract: An improved composition for inducing bone growth is provided that is a mixture of DBM and a perfluorocarbon oxygen carrier. Injection/implantation of a composition of DBM and a perfluorocarbon results in enhancement of bone formation.
    Type: Grant
    Filed: January 13, 2013
    Date of Patent: October 14, 2014
    Assignee: Theracell, Inc.
    Inventors: Andrew J. Carter, Nelson L. Scarborough, Richard K. Grant, Frank M. Phillips, Stephen H. Hochschuler
  • Publication number: 20140302112
    Abstract: Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.
    Type: Application
    Filed: June 20, 2014
    Publication date: October 9, 2014
    Inventors: Kevyan Benham, Guobao Wei, Nanette Forsyth
  • Publication number: 20140287055
    Abstract: Disclosed are phospholipid based compositions and implant devices, as well as methods and kits that include such compositions or components thereof. In particular, the present compositions include a polymer component such as a poloxamer or PEG component and a phospholipid component, such as a Phosal. The present compositions may include at least one additional component, such as granules, powder and/or particulates. The present compositions may further include one or more bone graft materials and/or active ingredients. The compositions may be used on their own or incorporated on or in a surgical implant.
    Type: Application
    Filed: March 18, 2014
    Publication date: September 25, 2014
    Applicant: GLOBUS MEDICAL, INC
    Inventor: Vipin Kunjachan
  • Publication number: 20140262006
    Abstract: A method for producing a polymer film includes: obtaining a load graph representing a functional relationship between a weight percentage of tissue forming nanoparticles in a polymer film and a maximum load of that polymer film; obtaining a stress graph representing a functional relationship between the weight percentage of tissue forming nanoparticles in a polymer film and maximum stress of that polymer film; determining a first weight percentage corresponding to a peak of the load graph and determining a second weight percentage corresponding to a peak of the stress graph; determining an optimal weight percentage based on the first and second weight percentage values; and producing a polymer film having tissue forming nanoparticles at the optimal weight percentage.
    Type: Application
    Filed: July 22, 2013
    Publication date: September 18, 2014
    Applicant: Board of Trustees of the University of Arkansas
    Inventor: Alexandru S. Biris
  • Publication number: 20140277570
    Abstract: This disclosure describes systems and methods for providing a novel delivery system for implantation in a patient. Further, this disclosure describes a delivery system including a carrier that is made of at least one monolithic bone tissue for retaining one or more substances.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Applicant: LANX, INC.
    Inventors: Keyvan Behnam, Jeffrey Thramann, Elizabeth Perez
  • Publication number: 20140255489
    Abstract: Embodiments of the present invention provides bone graft compositions, and methods for their use and manufacture. A bone graft composition may include a first amount of non-demineralized cancellous bone. The composition may further include a second amount of demineralized cancellous bone. The composition may also include a third amount of demineralized cortical bone. The non-demineralized cancellous bone, the demineralized cancellous bone, and the demineralized cortical bone may be obtained from the same cadaveric donor.
    Type: Application
    Filed: March 7, 2014
    Publication date: September 11, 2014
    Applicant: AlloSource
    Inventor: Yaling Shi
  • Publication number: 20140255506
    Abstract: An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation.
    Type: Application
    Filed: May 23, 2014
    Publication date: September 11, 2014
    Applicant: WARSAW ORTHOPEDIC, INC.
    Inventors: Keyvan Behnam, Nanette Forsyth, James Russell, John Winterbottom, Todd Boyce
  • Patent number: 8829166
    Abstract: A method for purifying bone-derived osteoinductive proteins including a demineralization process, a protein extraction process, a high molecular weight ultrafiltration process, a low molecular weight ultrafiltration process, and a recover process. The high and low ultrafiltration processes preferably select proteins having a nominal molecular weight between approximately 8 kilodaltons and approximately 100 kilodaltons. Processes of the present invention may be used to recover osteoinductive proteins from bone demineralization waste streams.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: September 9, 2014
    Assignee: Zimmer Orthobiologics, Inc.
    Inventors: Kevin Thorne, Rama Akella
  • Publication number: 20140242044
    Abstract: An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. Additionally, the implant may include, or have blended in, an additive, such as an osteoinductive factor, for example biocompatible ceramics and glass.
    Type: Application
    Filed: May 6, 2014
    Publication date: August 28, 2014
    Applicant: Kensey Nash BVF Technology LLC
    Inventors: Douglas G. EVANS, Scott M. Goldman, Russell T. Kronengold
  • Publication number: 20140220142
    Abstract: The present invention provides a composition for bone regeneration comprising: particulate demineralized bone matrix; fibrous demineralized bone matrix; and a hydrate. In addition, it is preferable that the present invention comprises a demineralized solution-derived isolated product obtained by neutralizing a demineralized solution, separated from a demineralization process, and separating the precipitate generated.
    Type: Application
    Filed: October 11, 2011
    Publication date: August 7, 2014
    Applicant: CG BIO CO., LTD.
    Inventors: Seok-Beom Song, Soo-Yong Kim, Jung-Won So, Han-Sol Seo, Hyun-Seung Ryu, Giue-Nam Kim, Byoung-Suck Kim
  • Publication number: 20140212471
    Abstract: An osteoinductive implantable composition comprising a mixture of demineralized bone fibers and mineralized bone fibers is provided. The mixture is visible under X ray and remodels more easily than comparable mixtures of demineralized bone matrix and surface demineralized cortical bone chips. The osteoinductive implantable compositions comprises demineralized bone fibers in an amount from about 30 vol % to about 45 vol % and mineralized bone fibers in an amount from about 55 vol % to about 70 vol %. The osteoinductive implantable compositions can be delivered in delivery systems including mesh coverings for administration at surgical sites. A method of treating a bone defect caused by injury, disease, wounds, or surgery utilizing the osteoinductive implantable composition comprising a mixture of demineralized bone fibers and mineralized bone fibers is also provided.
    Type: Application
    Filed: January 28, 2013
    Publication date: July 31, 2014
    Applicant: Warsaw Orthopedic, Inc.
    Inventors: Susan J. Drapeau, Guobao Wei
  • Publication number: 20140205674
    Abstract: Methods for increasing osteoinductivity and/or surface area of bone material are provided. The methods include providing bone material and dehydrating the bone material with a solvent at its critical point. A useful solvent for critical point dehydrating is carbon dioxide. Critical point dehydration resulting in increased osteoinductivity and/or surface area can be applied to many types of bone material including bone particles, bone chips, bone fibers, bone matrices, both demineralized and non-demineralized. An implantable composition having an enhanced osteoinductivity and/or osteoconductivity is also provided. The implantable composition contains demineralized bone matrix dried at critical point of carbon dioxide. Critical point dried fibers of a demineralized bone matrix have a BET value from about 40 m2/gm to about 100 m2/gm, a value that is 100 times higher than corresponding vacuum dried or lyophilized DBM fibers.
    Type: Application
    Filed: January 22, 2013
    Publication date: July 24, 2014
    Applicant: Warsaw Orthopedic, Inc.
    Inventor: Guobao Wei
  • Publication number: 20140199409
    Abstract: An improved composition for inducing bone growth is provided that is a mixture of DBM and a perfluorocarbon oxygen carrier. Injection/implantation of a composition of DBM and a perfluorocarbon results in enhancement of bone formation.
    Type: Application
    Filed: January 13, 2013
    Publication date: July 17, 2014
    Applicant: THERACELL, INC.
    Inventors: Andrew J. Carter, Nelson L. Scarborough, Richard K. Grant, Frank M. Phillips, Stephen H. Hochschuler
  • Publication number: 20140193379
    Abstract: Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.
    Type: Application
    Filed: January 8, 2014
    Publication date: July 10, 2014
    Applicant: United Therapeutics Corporation
    Inventors: Roger Jeffs, Thomas Petersen, Roger M. Ilagan, Michael Wade
  • Publication number: 20140193477
    Abstract: This disclosure relates to materials fabricated from collagen and uses relates thereto. Typically, layers of collagen are stretched during a curing period and optionally coated or impregnated with an elastin like protein. In certain embodiments, these materials can be used in tissue repair or arranged into cylinders and utilized as a prosthetic vascular graft.
    Type: Application
    Filed: October 11, 2013
    Publication date: July 10, 2014
    Applicants: Emory University, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Elliot Chaikof, Jeffrey Caves, Vivek Ashok Kumar, Adam W. Martinez
  • Patent number: 8771719
    Abstract: A method of producing a bone-polymer composite. The method comprises the steps of providing a plurality of bone particles, combining the bone particles with a polymer precursor, and polymerizing the polymer precursor.
    Type: Grant
    Filed: August 12, 2003
    Date of Patent: July 8, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Lawrence A. Shimp, John M. Winterbottom, Todd M. Boyce, David Knaack