Skeleton (e.g., Bone, Teeth, Etc.) Patents (Class 424/549)
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Patent number: 12232964Abstract: A bioabsorbable textile for the restoration of the joint function whereas the joint is affected by partial thickness tears, small to medium full-thickness tears, large to massive full-thickness tears, acute and chronic/degenerative tears. The bioabsorbable textile may comprise polymeric yarns interconnected to form a weave or knitted configuration, wherein said bioabsorbable textile provides a combined mechanical and biological augmentation in the target joint tissue. The bioabsorbable textile may be implanted in combination with fixation tools during open, mini-open or arthroscopic repair/augmentation procedures of joint tissue tears.Type: GrantFiled: November 30, 2021Date of Patent: February 25, 2025Assignee: Anika Therapeutics, Inc.Inventors: Stefano Agnello, Edward Ahn, Matteo Centola, Steven W. Ek, Stephen J. Kennedy, Matthew M. Mannarino, Elvira Marchetto, Sonali Puri, Robert Richard, Sara Simoncioni
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Patent number: 12220499Abstract: A method for producing non-resorbable bone allografts having improved osteoconductivity and biocompatibility in regenerative dental and medical applications as compared with non-resorbable xenografts. The method comprises excising one or more bone allografts from a donor's body; freeze-drying the bone allografts; demineralizing the freeze-dried bone allografts; preserving and sterilizing the bone allografts; and thermal processing of the bone allografts at a temperature greater than about 300 degrees Celsius.Type: GrantFiled: October 22, 2019Date of Patent: February 11, 2025Assignee: Miron Research and Development in Dentistry, LLCInventor: Richard John Miron
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Patent number: 12144909Abstract: A biocompatible material for bone repair is described. The bone repair composition includes a mixture of a type I collagen, a type I collagen-glycosaminoglycan coprecipitate, tricalcium phosphate; and bioactive glass. Methods of using the composition for bone repair, and a kit for the bone repair composition are also described.Type: GrantFiled: December 29, 2020Date of Patent: November 19, 2024Assignee: ZAVATION MEDICAL PRODUCTS, LLCInventors: Jeffrey Johnson, Nels J Lauritzen, Brent Mitchell
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Patent number: 12137952Abstract: A device used in conjunction with fixation hardware to provide a two-stage process to address the competing needs of immobilization and re-establishment of normal stress-strain trajectories in grafted bone. A method of determining a patient-specific stress/strain pattern that utilizes a model based on 3D CT data of the relevant structures and cross-sectional data of the three major chewing muscles. The forces on each of the chewing muscles are determined based on the model using predetermined bite forces such that a stiffness of cortical bone in the patient's mandible is determined. Based on the stiffness data, suitable implantation hardware can be designed for the patient by adjusting external topological and internal porous geometries that reduce the stiffness of biocompatible metals to thereby restore normal bite forces of the patient. A method of 3D printing nitinol to create a patient-specific device to facilitate the establishment of a normal stress-strain trajectory in grafted bone.Type: GrantFiled: January 18, 2023Date of Patent: November 12, 2024Assignees: OHIO STATE INNOVATION FOUNDATION, THE UNIVERSITY OF TOLEDOInventors: Howard David Dean, Mohammad H. Elahinia, Christoph Haberland, Michael J. Miller, Alok Sutradhar, Narges Shayesteh Moghaddam, Jason M. Walker, Roman Skoracki
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Patent number: 12076459Abstract: The present disclosure relates to a bone graft composition, and more particularly, to a bone graft composition containing hydroxypropyl methylcellulose and a preparation method therefor. Moreover, the present disclosure relates to a bone graft composition that has an optimal composition ratio at which the dissolution rate of hydroxypropyl methylcellulose is excellent.Type: GrantFiled: July 10, 2020Date of Patent: September 3, 2024Assignee: MedPark Co., LtdInventor: JungBok Park
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Patent number: 12023417Abstract: A method is provided for pre-stretching implantable biocompatible materials, such as material to be incorporated into an implantable device. A sheet of implantable biocompatible material is attached to one or more tensioning members, where tension is applied along one or more axes. Tension is applied for a period of time, and at an appropriate force, to produce a desired degree of thinning or pre-stretching of the implantable biocompatible material. During the tensioning, the implantable biocompatible material is maintained at an elevated temperature, such as a temperature that is at least substantially a temperature of an environment into which the material will be implanted.Type: GrantFiled: July 20, 2020Date of Patent: July 2, 2024Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: David Maimon, Tamir S. Levi, Elena Sherman
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Patent number: 11622979Abstract: A composition for the treatment of wounds includes demineralized bone fibers (DBF) derived from allogeneic or xenogenic cortical bone and/or polymeric fibers made from resorbable and/or non-resorbable polymer, and the composition may also include an oxygen-generating material and/or an oxygen carrier.Type: GrantFiled: May 21, 2021Date of Patent: April 11, 2023Assignee: TETROUS, INC.Inventors: Andrew J. Carter, Bradley E. Patt, Nelson L. Scarborough
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Patent number: 11576999Abstract: The present disclosure relates to compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of preparing compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of using the bone compositions, bone implants and variants thereof.Type: GrantFiled: August 7, 2020Date of Patent: February 14, 2023Assignee: LifeNet HealthInventors: Michael Francis, Rudy Rodriquez, Nathan Kemper, Silvia Chen
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Patent number: 11452796Abstract: The disclosure provides bone graft materials, methods for their use and manufacture. Exemplary bone graft materials comprise combining a radiopaque component with a cancellous bone component to produce a bone graft material, wherein the cancellous bone component comprises native osteoreparative cells. Methods for treating a subject with the bone graft material are also provided.Type: GrantFiled: June 29, 2018Date of Patent: September 27, 2022Assignee: AlloSourceInventors: Reginald Stilwell, Ramasamy Sakthivel, William Maslanik
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Patent number: 11406734Abstract: A malleable demineralized bone composition consists of cortical bone made from a first portion and a second portion. The first portion and second portion of cortical bone is made from cut pieces freeze dried then ground into particles and demineralized then freeze-dried. A volume of the second portion is placed in a solution of sterile water to create a mixture, the water volume being seven times the volume of the second portion, the mixture is autoclaved under heat and pressure to form a gelatin, and the first portion is mixed with the gelatin to form a malleable putty or paste.Type: GrantFiled: October 15, 2020Date of Patent: August 9, 2022Assignee: Vivex Biologics Group, Inc.Inventors: Silvia Daniela Gonzales, Shabnam Namin, Timothy Ganey
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Patent number: 11364094Abstract: The invention relates to the application of a composition containing recombinant amelogenin and propylene glycol alginate (“PGA”) on to cut dentin tubules followed by installation of a definitive restorative in a single visit.Type: GrantFiled: August 23, 2021Date of Patent: June 21, 2022Assignee: King Abdulaziz UniversityInventors: Laila Ahmed Salim Bahammam, Maha M. F. Mounir
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Patent number: 11337777Abstract: The invention relates to the application of a composition containing recombinant amelogenin and propylene glycol alginate (“PGA”) on to cut dentin tubules followed by installation of a definitive restorative in a single visit.Type: GrantFiled: August 27, 2021Date of Patent: May 24, 2022Assignee: King Abdulaziz UniversityInventors: Maha M. F. Mounir, Laila Ahmed Salim Bahammam
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Patent number: 11324568Abstract: The invention relates to the application of a composition containing recombinant amelogenin and propylene glycol alginate (“PGA”) on to cut dentin tubules followed by installation of a definitive restorative in a single visit.Type: GrantFiled: July 30, 2021Date of Patent: May 10, 2022Assignee: King Abdulaziz UniversityInventors: Laila Ahmed Salim Bahammam, Maha M. F. Mounir
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Patent number: 11207155Abstract: The invention relates to the application of a composition containing recombinant amelogenin and propylene glycol alginate (“PGA”) on to cut dentin tubules followed by installation of a definitive restorative in a single visit.Type: GrantFiled: June 21, 2021Date of Patent: December 28, 2021Assignee: King Abdulaziz UniversityInventors: Laila Ahmed Salim Bahammam, Maha M. F. Mounir
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Patent number: 11077148Abstract: A biological composition has a mixture of mechanically selected allogeneic biologic material derived from placental tissue. The mixture has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components. The mixture including non-whole cell fractions including one or more of exosomes, transcriptosomes, proteasomes, membrane rafts, lipid rafts. The mixture is compatible with biologic function.Type: GrantFiled: April 11, 2018Date of Patent: August 3, 2021Assignee: Vivex Biologics Group, Inc.Inventors: Timothy Ganey, Wendy W. Weston, Gaëtan Jean-Robert Delcroix
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Patent number: 10849930Abstract: In particular, a composition for breast augmentation that includes a composition promoting an increase in subcutaneous tissue, wherein the promoting composition aims at accumulating and increasing adipose tissue under the skin of a breast by generating and increasing the adipose tissue around a mammary gland and enables recovery of autologous tissue and recovery of appearance by a safe and natural process, and a method for breast augmentation are provided. A composition promoting an increase in subcutaneous tissue that contains autologous plasma and a basic fibroblast growth factor (b-FGF), in particular, a composition for breast augmentation is provided. A composition for breast augmentation that includes the above-described composition promoting an increase in subcutaneous tissue that further contains fat is provided.Type: GrantFiled: February 21, 2013Date of Patent: December 1, 2020Inventor: Kensuke Yamakawa
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Patent number: 10780196Abstract: The present disclosure relates to compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of preparing compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of using the bone compositions, bone implants and variants thereof.Type: GrantFiled: October 9, 2014Date of Patent: September 22, 2020Assignee: LifeNet HealthInventors: Michael Francis, Rudy Rodriguez, Nathan Kemper, Silvia Chen
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Patent number: 10760058Abstract: A biological composition has a mixture of mechanically selected allogeneic biologic material derived from bone marrow. The mixture has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components. The mixture including non-whole cell fractions including one or more of exosomes, transcriptosomes, proteasomes, membrane rafts, lipid rafts. The mixture is compatible with biologic function.Type: GrantFiled: May 9, 2017Date of Patent: September 1, 2020Assignee: Vivex Biologics Group, Inc.Inventors: Timothy Ganey, Wendy W. Weston, Miguel Quevedo, Stuart Oglesby, Gaetan Jean-Robert Delcroix, Paul C. Schiller, Gianluca D'Ippolito
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Patent number: 10736993Abstract: Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth. The compression resistant implant comprises a biodegradable polymer in an amount of about 0.1 wt % to about 20 wt % of the implant and a freeze-dried oxysterol in an amount of about 5 wt % to about 90 wt % of the implant. Methods of making and use are further provided.Type: GrantFiled: February 8, 2019Date of Patent: August 11, 2020Assignee: Warsaw Orthopedic, Inc.Inventors: Benjamin T. Reves, David S. Scher, Roger E. Harrington, Jerbrena C. Jacobs
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Patent number: 10730918Abstract: The present invention for the first time discloses a novel small molecular weight enamel matrix polypeptide which is at least 80%, such as 90% identical to the amino acid sequence as shown in SEQ ID NO: 1 (MPLPPHPGHP GYINFSYEVL TPLKWYQNMI RHPYTSYGYE PMGGWLHHQI IPWSQQTPQ SHA) (TRAP63), a homologue, analogue, or a pharmaceutically acceptable salt thereof. The present invention further discloses a pharmaceutical composition consisting of an enamel matrix polypeptide which is at least 80%, such as 90% identical to the amino acid sequence as shown in SEQ ID NO: 1, a homologue, analogue, or a pharmaceutically acceptable salt thereof, and a suitable pharmaceutical carrier, which further can consist of one or more enamel matrix polypeptides selected from the group of enamel matrix polypeptides which correspond to: a. SEQ ID NO: 2, b. SEQ ID NO: 3 and c. SEQ ID NO: 4.Type: GrantFiled: April 30, 2014Date of Patent: August 4, 2020Assignee: STRAUMANN HOLDING AGInventors: Anja C. Gemperli, Oleh Andrukhov
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Patent number: 10531957Abstract: Surgical implants (or grafts) for the repair of bone defects, more particularly, surgical implants that include demineralized bone fibers, are disclosed. The surgical implants have a wettability time of less than 5 minutes and a residual moisture content of less than 6% by weight, and they remain cohesive and retain their shape upon complete rehydration. Methods for making such implants and for increasing their wettability and ensuring uniform density are also disclosed.Type: GrantFiled: May 19, 2016Date of Patent: January 14, 2020Assignee: Musculoskeletal Transplant FoundationInventors: Michele McAllister, David Wang, Michelle Bubear, Joed Canales, Amy Chang, Roman Shikhanovich, Mark Spilker, Eric Semler
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Patent number: 10532131Abstract: The invention relates to a porous osteoinductive calcium phosphate material having an average grain size in a range of 0.1-1.50 ?m, having a porosity consisting essentially only of micropores in a size range of 0.1-1.50 ?m, and having a surface area percentage of micropores in a range of 10-40%.Type: GrantFiled: July 6, 2015Date of Patent: January 14, 2020Assignee: NuVasive Netherlands B.V.Inventors: Huipin Yuan, Joost Dick de Bruijn
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Patent number: 10507265Abstract: A bone implant comprising cancellous bone that is essentially free of blood cells, and which has been treated with at least a loosening agent, such as collagenase and/or a digestive enzyme, for a time and at a concentration to loosen the osteogenic cells in the cancellous bone matrix. The osteogenic cells in the matrix are viable cells. The treatment of the cancellous bone with at least one loosening agent enables the osteogenic cells to be more available for carrying out their osteogenic function and to provide for an increased rate of bone formation.Type: GrantFiled: May 16, 2017Date of Patent: December 17, 2019Assignee: NuVasive, Inc.Inventors: Michelle LeRoux Williams, Charles Randal Mills, Rodney Monroy
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Patent number: 10286104Abstract: A carbonate apatite prepared from natural bone. The carbonate apatite has a protein content of 2000-8000 parts per million and a surface area of 15 to 70 m2/g. Also provided is a method for preparing the carbonate apatite from cancellous bone particles.Type: GrantFiled: March 6, 2017Date of Patent: May 14, 2019Assignee: Collagen Matrix, Inc.Inventors: Shu-Tung Li, Hui-Chen Chen, Debbie Yuen
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Patent number: 10201635Abstract: Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth. The compression resistant implant comprises a biodegradable polymer in an amount of about 0.1 wt % to about 20 wt % of the implant and a freeze-dried oxysterol in an amount of about 5 wt % to about 90 wt % of the implant. Methods of making and use are further provided.Type: GrantFiled: October 27, 2015Date of Patent: February 12, 2019Assignee: Warsaw Orthopedic, Inc.Inventors: Benjamin T. Reves, David S. Scher, Roger E. Harrington, Jerbrena C. Jacobs
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Patent number: 10130736Abstract: The disclosure provides implants containing a plurality of particles containing at least one population of viable osteogenic cells adherent to and resident in an osteoconductive matrix or at least one viable population of osteogenic cells caused to be in contact with the osteoconductive matrix; methods of fabricating the implants; and use of the implants in bone repair. The implant further contains an osteoinductive component. An example of an osteoinductive component is a demineralized bone matrix in the form of particles or fibers.Type: GrantFiled: November 5, 2015Date of Patent: November 20, 2018Assignee: Musculoskeletal Transplant FoundationInventors: Eric Semler, Alex Callahan, Joed Canales, Katrina Carroll, Anouska Dasgupta, Roman Shikhanovich
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Patent number: 9968704Abstract: A method for regenerating alveolar bone in which bone tissue is regenerated in the gap between an implant or dental root and alveolar bone, which comprises a procedure consisting of making an incision in the gingiva surrounding an implant or dental root embedded in alveolar bone, blowing a first air into the gap between the implant or dental root and the alveolar bone to remove a portion of infected granulation tissue present in the gap, and irradiating the gap with laser light to degenerate the infected granulation tissue remaining in the gap, followed by blowing a second air containing microparticles having calcium as a constituent thereof and water into the gap to remove the degenerated infected granulation tissue and fill in the gap with the wet microparticles.Type: GrantFiled: April 19, 2012Date of Patent: May 15, 2018Assignee: BIO MAP CO., LTD.Inventors: Naoko Kajimoto, Kyousuke Kajimoto, Tadamori Kajimoto
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Patent number: 9789190Abstract: Enamel Matrix Derivative (EMD) proteins and enamel matrix proteins are widely used in clinical dentistry because of their ability to promote regeneration of soft and hard tissues and to reduce inflammation and infections. The present invention relates to the surprising finding that a pharmaceutical, dental and/or cosmetic formulation, which comprises purified Enamel Matrix Derivative (EMD) proteins and/or enamel matrix proteins and sterilized Propylene Glycol Alginate (PGA), wherein the sterilized PGA is obtained from non-sterilized PGA having a weight average molecular weight (Mwo) of between 250-500 kDa, is more stable over time, especially, the pH is more stable over time.Type: GrantFiled: October 17, 2011Date of Patent: October 17, 2017Assignee: STRAUMANN HOLDING AGInventors: Laszlo Garamszegi, Andri Vital
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Patent number: 9687511Abstract: A biological composition has a mixture of mechanically selected allogeneic biologic material derived from bone marrow. The mixture has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components. The mixture including non-whole cell fractions including one or more of exosomes, transcriptosomes, proteasomes, membrane rafts, lipid rafts. The mixture is compatible with biologic function.Type: GrantFiled: April 9, 2015Date of Patent: June 27, 2017Assignee: Vivex Biomedical, Inc.Inventors: Wendy W. Weston, Miguel Quevedo, Stuart Oglesby, Gaëtan Jean-Robert Delcroix, Paul C. Schiller, Gianluca D'Ippolito, Timothy Ganey
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Patent number: 9585764Abstract: An osteoimplant device is provided. The osteoimplant device includes a body of nondemineralized cortical bone and an outer surface having at least one region including demineralized bone. The osteoimplant device is formable into a shape and size configured for implantation at a surgical site. A disc shaped osteoimplant can be used for a facet joint fusion. A method of treating a patient having a bone defect in a host bone is also provided, the method including inserting the osteoimplant into the bone defect, for example, one associated with a facet joint.Type: GrantFiled: July 26, 2012Date of Patent: March 7, 2017Assignee: Warsaw Orthopedic, Inc.Inventor: William F. McKay
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Patent number: 9339589Abstract: The invention is directed to an apparatus for producing demineralized osteoinductive bone. The apparatus demineralizes bone by subjecting bone, including, for example, ground bone, bone cubes, chips, strips, or essentially intact bone, to either a rapid high volume pulsatile acidification wave process or to a rapid continuous acid demineralization process. The pulsatile acidification wave process includes subjecting bone to two or more rapid pulse/drain cycles in which one or more demineralizing acids is rapidly pulsed into a vessel containing bone, and after a desired period of time, is rapidly drained from the vessel. The continuous acid demineralization process includes subjecting bone to a continuous exchange of demineralizing acid solution in which the demineralizing acid solution is recirculated from the container holding the bone through an ion exchange media.Type: GrantFiled: December 6, 2012Date of Patent: May 17, 2016Assignee: LifeNet HealthInventors: Debra Moore-Smith, Robert K. O'Leary, Anne Wilson
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Patent number: 9198884Abstract: Carboxymethylcellulose, notably sodium carboxymethylcellulose or other alkali metal or alkaline earth metal salts of carboxymethylcellulose, are employed to control solidification time of compositions comprising one or more bioresorbable ceramics, notably a hydratable calcium sulphate, in order to facilitate preparation of a ready-to-use composition for inserting into the body by injection.Type: GrantFiled: November 27, 2009Date of Patent: December 1, 2015Assignee: LIDDS ABInventors: Lars Åke Malmsten, Niklas Axén, Hans Lennernäs, Anders Carlsson
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Publication number: 20150147397Abstract: This invention is directed to aragonite and calcite hydrogel biomatrices, optionally seeded with precursor cells and uses thereof in tissue engineering, regeneration and repair, including in inducing or enhancing bone formation, cartilage formation or a combination thereof in a subject, and kits related thereto.Type: ApplicationFiled: April 29, 2013Publication date: May 28, 2015Inventor: Nir Altschuler
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Publication number: 20150147408Abstract: A Method Validation Unit (MVU) for the evaluation of the level of sterilisation in a sterilisation method involving the use of a fluid at or near the supercritical pressure and temperature for that fluid, wherein the MVU comprises a sterilisation indicator housed within a gas-permeable container, wherein the sterilisation indicator comprises an indicator medium and a population of one or more colony forming units (CFUs), and wherein the indicator medium comprises one or more structural features representative of the internal structure of a material to be sterilised in the sterilisation method.Type: ApplicationFiled: May 30, 2013Publication date: May 28, 2015Applicant: Austrialian Biotechnologies PTY. LimitedInventors: Simon Jonothan Berry, Sharon Bryce, Jerome Alon Goldberg
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Publication number: 20150140116Abstract: The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices. The intrinsic bioactivity of the hydrogel matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implanted device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissue bulking.Type: ApplicationFiled: January 30, 2015Publication date: May 21, 2015Inventors: Francis Vincent Lamberti, Richard Chris Klann, Ronald Stewart Hill
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Publication number: 20150140115Abstract: The present invention relates to oriental medicine compositions marked as SEC 22 and SEC 33 for improving digestive functions and respiratory functions for improving children's underweight, low growth and depressed respiratory organ, an oriental medicine derived therefrom, and methods of preparing them. According to an example of the present invention, the oriental medicine composition containing broiled fruit of Crataegus pinnatifida, broiled root of Atractylodes japonica, dried peel of Citrus unshiu, broiled sprout of Hordeum vulgare, broiled fruit of Amomum xanthioides, root of Zingiber officinale, dried fruit of Zizyphi, and horn of Cervus elaphus.Type: ApplicationFiled: November 19, 2014Publication date: May 21, 2015Inventor: Ki Joon Kim
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Publication number: 20150118160Abstract: A composition of a bone repair mixture has a quantity of allograft particulate bone having a bone particle distribution of particle sizes less than 700 micron and a quantity of biologic carrier material intermixed with the particulate bone. The biologic carrier material is one of fascia, deep fascia or a fascia mixture. Preferably, the carrier material is exclusively fascia lata.Type: ApplicationFiled: January 6, 2015Publication date: April 30, 2015Applicant: VIVEX BIOMEDICAL INC.Inventors: Tracy Scott Anderson, Timothy E. Taylor
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Patent number: 9017711Abstract: Compositions and methods for treating and healing injured soft tissues such as tendons and ligaments are provided. The composition may be a wrap comprising human collagen in the form of a sheet. The human collagen has been processed so that is retains proteins that are associated with it in its natural state. The sheet may optionally be coated on one or more sides with one or more of additional human collagen, therapeutic agents, additional soft tissue growth factors or hydroxyapatite.Type: GrantFiled: April 28, 2011Date of Patent: April 28, 2015Assignee: Warsaw Orthopedic, Inc.Inventors: Nels J. Lauritzen, Abdulhafez A. Selem, Lawrence A. Shimp, Hsiu Ying Sherry Wang
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Publication number: 20150110891Abstract: The subject of the present invention is a bioactive cell homogenate produced from cells belonging to the MIC-1 stem cell line derived from growing deer antlers (Cervidae) deposited at the DSMZ under the accession DSM ACC2854, a method of producing and using it. The present invention also encompasses a pharmaceutical or cosmetic composition containing the above-mentioned homogenate.Type: ApplicationFiled: October 29, 2014Publication date: April 23, 2015Applicant: STEM CELLS SPIN S.A.Inventors: Wojciech DZIEWISZEK, Marek CEGIELSKI, Marek BOCHNIA
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Publication number: 20150110890Abstract: A method of preparing a bone graft. Mixing bone marrow aspirate with an effective amount of a binding reagent that is capable of binding with red blood cells in the bone marrow aspirate. The bound red blood cells are aggregated. The aggregated bound red blood cells are separated from the bone marrow aspirate to provide a supernatant. At least a portion of the supernatant is associated with an osteoconductive matrix to form the bone graft.Type: ApplicationFiled: October 17, 2014Publication date: April 23, 2015Inventor: Robert Assell
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Patent number: 9011930Abstract: Nutritional supplements and methods for maintaining and/or improving the condition of bones or cartilage in a mammal, particularly a human. One such supplement comprises demineralized bone matrix (DBM) wherein the DBM comprises a bone growth improving amount of at least one osteoinductive growth factor. A preferred supplement composition further comprises at least one vitamin, such as vitamin E. One method comprises orally administering to the mammal on a periodic basis a supplement comprising DBM. In a preferred method the DBM composition is periodically administered and there is a further periodic administration of a therapeutically effective amount of a calcium-containing composition; the calcium-containing composition is administered temporally spaced apart from said DBM composition for maximum effectiveness.Type: GrantFiled: May 1, 2006Date of Patent: April 21, 2015Assignee: ZyCal Bioceuticals Healthcare Company, Inc.Inventor: James Scaffidi
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Publication number: 20150093429Abstract: A bone repair composition and methods thereof include elongated bone fibers made from cortical bone in which a plurality of approximately uniform bone fibers is made into various implant shapes conducive for various applications. The bone fiber compositions may be in the form of a cavity, ball, pellet, wrap, strip, cylinder, cone, putty, gel, or injectable slurry.Type: ApplicationFiled: December 11, 2014Publication date: April 2, 2015Applicant: THERACELL, INC.Inventors: Andrew J. Carter, Nelson L. Scarborough, Bradley Patt
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Patent number: 8992965Abstract: An osteoinductive composition, corresponding osteoimplants, and methods for making the osteoinductive composition are disclosed. The osteoinductive composition comprises osteoinductive factors, such as may be extracted from demineralized bone, and a carrier. The osteoinductive composition is prepared by providing demineralized bone, extracting osteoinductive factors from the demineralized bone, and adding the extracted osteoinductive factors to a carrier. Further additives such as bioactive agents may be added to the osteoinductive composition. The carrier and osteoinductive factors may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, can induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. Also, in some embodiments, the osteoinductive composition can be used as a delivery device to administer bioactive agents.Type: GrantFiled: November 1, 2006Date of Patent: March 31, 2015Assignee: Warsaw Orthopedic, Inc.Inventor: Keyvan Behnam
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Patent number: 8992964Abstract: A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.Type: GrantFiled: April 23, 2012Date of Patent: March 31, 2015Assignee: Bacterin International, Inc.Inventors: Nancy J. Shelby, Steven M. Scott, Benjamin P. Luchsinger, Gregory A. Juda, Kelly R. Kirker, Jesus Hernandez, Darrel L. Holmes
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Patent number: 8980328Abstract: A method for preparing carbonate apatite from natural bones. The method includes obtaining cancellous bone particles; treating the bone particles with hot water and an organic solvent; repeating the treating step at least once; drying the bone particles; and heating the bone particles at 500° C. to 620° C. for 10 to 50 hours.Type: GrantFiled: September 29, 2011Date of Patent: March 17, 2015Assignee: Collagen Matrix, Inc.Inventors: Shu-Tung Li, Hui-Chen Chen, Debbie Yuen
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Publication number: 20150050358Abstract: This disclosure describes an implant support composition and methods of using the implant support composition. Generally, the implant support composition includes a filler, an osteoconductive material, an osteoinductive material, and an antimicrobial agent.Type: ApplicationFiled: August 14, 2014Publication date: February 19, 2015Inventors: Wook-Jin Seong, James Edward Hinrichs, Robert Joseph Schumacher
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Publication number: 20150037432Abstract: The present invention is a composition of a self-assembly of collagen fibers made from a plurality of sized pieces of a source material. The source material made from animal or human tissue selected from one of dermis, tendon, fascia or dura mater. The self-assembly occurring by induction of a magnetic field in a liquid medium.Type: ApplicationFiled: July 31, 2013Publication date: February 5, 2015Applicant: VIVEX BIOMEDICAL INC.Inventor: Theodore I. Malinin
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BONE REGENERATION USING BIODEGRADABLE POLYMERIC NANOCOMPOSITE MATERIALS AND APPLICATIONS OF THE SAME
Publication number: 20150030660Abstract: A structure of, and a method of producing, a biocompatible structure for bone and tissue regeneration are disclosed. The method includes dissolving a polyurethane polymer in methanol, adding hydroxyapatite (HAP) nanoparticles to form a uniformly distributed mixture, applying the mixture to a polytetrafluoroethylene (PTFE) surface to form a polymer film, cutting the polymer film into strips, stacking the strips with layers of bone particles disposed therebetween, coating the stacked strips and layers by the mixture and allowing it to dry, adding bone particles to the coating, and plasma treating the structure to form the biocompatible structure. A weight percentage of the HAP nanoparticles to the polymer is about 5-50% such that a resorption rate of the biocompatible structure substantially matches a rate of tissue generation in the biocompatible structure.Type: ApplicationFiled: October 3, 2014Publication date: January 29, 2015Inventor: Alexandru S. Biris -
Publication number: 20150010607Abstract: The invention relates to methods of preparing a bone matrix solution, a bone matrix implant, and variants thereof. The invention also relates to methods of cell culture using the same. The invention further relates to bone matrix scaffolds comprising one or more bone matrix nanofibers, methods of preparing, and methods of use thereof. The invention also relates to methods of culturing cells and promoting differentiation of stem cells using the same.Type: ApplicationFiled: February 7, 2013Publication date: January 8, 2015Inventors: Michael Francis, Roy Ogle
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Publication number: 20150010510Abstract: Methods of manufacturing a bone-derived extracellular matrix (bECM) product are provided. Also provided are bECM products and methods of using those products.Type: ApplicationFiled: July 3, 2014Publication date: January 8, 2015Inventors: Stephen F. Badylak, Michael J. Sawkins, Kevin M. Shakesheff, Lisa J. White