Gastrointestinal System (e.g., Intestine, Stomach, Gall Bladder, Etc.) Patents (Class 424/551)
  • Patent number: 5445833
    Abstract: Surgical repair of diseased or damaged endogenous connective tissue can be accomplished using a tissue graft formed from a delaminated segment of intestinal tissue. The tissue graft comprises the intestinal tunica submucosa, and basilar mucosa tissue delaminated from the tunica muscularis and the luminal portion of the tunica mucosa. The graft can be conditioned by stretching and formed as a multilayer composition for high tensile strength and resistance to tearing at its points of attachment to existing physiological structures.
    Type: Grant
    Filed: December 15, 1993
    Date of Patent: August 29, 1995
    Assignees: Purdue Research Foundation, Methodist Hospital of Indiana, Inc.
    Inventors: Stephen F. Badylak, Leslie A. Geddes, K. Donald Shelbourne, Gary C. Lantz, Arthur C. Coffey
  • Patent number: 5436003
    Abstract: This invention relates to a beta-fructofuranosidase enzyme food supplement composition, which alleviates gastrointestinal distress caused by ingested food containing oligosaccharides, comprising a beta-fructofuranosidase enzyme, a cellulase enzyme and a hemicellulase enzyme. More particularly, the enzyme food supplement composition of this invention comprises a beta-fructofuranosidase enzyme, a cellulase enzyme, a hemicellulase enzyme, a lipase enzyme and an acid protease enzyme. This invention also relates to a method of alleviating gastrointestinal distress in the gastrointestinal system of a human being, which distress is caused by ingested food containing oligosaccharides, the method comprising the step of ingesting a beta-fructofuranosidase enzyme food supplement composition comprising a beta-fructofuranosidase enzyme, a cellulase enzyme and a hemicellulase enzyme, to convert oligosaccharides contained in the ingested food to reducing sugars.
    Type: Grant
    Filed: December 5, 1994
    Date of Patent: July 25, 1995
    Assignee: Triarco Industries, Inc.
    Inventors: Rodger R. Rohde, Jr., Edward F. Schuler, Richard A. Handel
  • Patent number: 5372821
    Abstract: Surgical repair of diseased or damaged endogenous connective tissue can be accomplished using a tissue graft formed from a delaminated segment of intestinal tissue. The tissue graft comprises the intestinal tunica submucosa and basilar mucosa tissue delaminated from the tunica muscularis and the luminal portion of the tunica mucosa. The graft can be conditioned by stretching and formed as a multilayer composition for high tensile strength and resistance to tearing at its points of attachment to existing physiological structures.
    Type: Grant
    Filed: December 15, 1993
    Date of Patent: December 13, 1994
    Assignee: Purdue Research Foundation
    Inventors: Stephen F. Badylak, Leslie A. Geddes, K. Donald Shelbourne, Gary C. Lantz, Arthur C. Coffey
  • Patent number: 5352463
    Abstract: A fluidized, injectable tissue graft composition is described. The composition comprises comminuted intestinal submucosa or protease-digested intestinal submucosa. Methods for the preparation and use of injectable tissue graft compositions are described. In preferred embodiments the tissue graft material is prepared from the intestinal submucosa comprising the tunica submucosa, the muscularis mucosa and the stratum compactum of a segment of intestinal tissue of a warm-blooded vertebrate. Effective amounts of the fluidized graft compositions can be injected to promote repair tissue defects by inducing formation of endogenous tissues.
    Type: Grant
    Filed: November 13, 1992
    Date of Patent: October 4, 1994
    Inventors: Steven F. Badylak, Robert J. Demeter, Michael Hiles, Sherry Voytik, Peter M. Knapp, Jr.
  • Patent number: 5314698
    Abstract: The present invention relates to an improved method for isolating brush border membranes from insects. The method can be used to isolate brush border membranes from small insects.
    Type: Grant
    Filed: February 7, 1992
    Date of Patent: May 24, 1994
    Assignee: Novo Nordisk A/S
    Inventor: Susan C. MacIntosh
  • Patent number: 5281422
    Abstract: Surgical repair of diseased or damaged endogenous connective tissue can be accomplished using a tissue graft formed from a delaminated segment of intestinal tissue. The tissue graft comprises the intestinal tunica submucosa, muscularis mucosa and stratum compactum delaminated from the tunica muscularis and the luminal portion of the tunica mucosa. The graft can be conditioned by stretching and formed as a multilayer composition for high tensile strength and resistance to tearing at its points of attachment to existing physiological structures.
    Type: Grant
    Filed: September 24, 1991
    Date of Patent: January 25, 1994
    Assignee: Purdue Research Foundation
    Inventors: Stephen F. Badylak, Leslie A. Geddes, K. Donald Shelbourne, Gary C. Lantz, Arthur C. Coffey
  • Patent number: 5275826
    Abstract: A fluidized, injectable tissue graft composition is described. The composition comprises comminuted intestinal submucosa or protease-digested intestinal submucosa. Methods for the preparation and use of injectable tissue graft compositions are described. In preferred embodiments the tissue graft material is prepared from the intestinal submucosa comprising the tunica submucosa, the muscularis mucosa and the stratum compactum of a segment of intestinal tissue of a warm-blooded vertebrate. Effective amounts of the fluidized graft compositions can be injected to promote repair tissue defects by inducing formation of endogenous tissues.
    Type: Grant
    Filed: November 13, 1992
    Date of Patent: January 4, 1994
    Inventors: Stephen F. Badylak, Robert J. Demeter, Michael Hiles, Sherry Voytik, Peter M. Knapp, Jr.
  • Patent number: 5268175
    Abstract: Topical cosmetic and pharmaceutical compositions are provided for the external protection of human or animal tissues from contact with heavy metals, and the composition includes a metal sequestering component capable of binding metal ions and a physiologically inert carrier suitable for topical administration. The metal sequestering component one or more metal binding peptide having a high proportion of cysteine residues, for example a metallothionein.
    Type: Grant
    Filed: March 24, 1992
    Date of Patent: December 7, 1993
    Assignee: Indena SpA
    Inventors: Ezio Bombardelli, Cesare Ponzone, Pier P. Puglisi
  • Patent number: 5225203
    Abstract: A pharmaceutical liquid composition such as suspension, gel, or sol preparation, contains Bezoar bovis, Dioscoreae rhizoma, Glycyrrhizae radix, Ginseng radix, Typhae Pollen, Massa medicata fermentata, Sojae germinatum Semen, Cinnamomi cortex, Gelatin, Paeoniae radix liriopis Tuber, Scutellariae radix, Angelicae gigantis radix, Ledebouriellae radix, Atractylodis rhizoma alba, Bupleuri radix, Platycodi radix, Armeniacae Semen, Hoelen, Cnidii rhizoma, Antellopis cornu, Moschus, Borneol, Ampelopsis radix, and Zingiberis rhizoma for easy oral and parental administration thereof to critical patients.
    Type: Grant
    Filed: May 4, 1992
    Date of Patent: July 6, 1993
    Inventor: Young S. Kim
  • Patent number: 5198230
    Abstract: This invention provides a recipe for making a detoxification medicine named DTS (Deities) for curing drug addiction. This DTS (Deities) medicine comprises no narcotic but mainly is made up by several kinds of effective ingredients of biological substances refined from various natural herbs and bioproducts. Drug addicts can be weaned and cured safely from addiction induced by Heroin, Cocaine, Morphine, Amphetamines, Hemp or Opium, and other substances within 7-30 days, by means of DTS (Deities) which can get rid of drug poisons present in an addict's blood and marrow. Further, DTS (Deities) can also be used to clear away tobacco tar and nicotine deposits so that it serves to wean from cigarette smoking as well.
    Type: Grant
    Filed: January 8, 1991
    Date of Patent: March 30, 1993
    Inventor: Liu C. Wen
  • Patent number: 5190757
    Abstract: A pharmaceutical liquid composition prepared by combining a predetermined quantity of natural substances from the genera Glycyrrhizae Radix, Ginseng Radix, Typhae Pollen, Massa Medicata Fermentata, Sojae germinatum Semen, Cinnamomi Cortex, Gelatin, Paeoniae Radix, Liriope Tuber, Scutellariae Radix, Angelicae Gigantis Radix, Ledebouriellae Radix, Atractylodis Rhizoma Alba, Bupleuri Radix, Platycodi Radix, Armeniacae Semen, Hoelen, Cnidii Rhizoma, Antellopis Cornu, Ampelopsis Radix, Zingiberis Rhizoma, Dioscoreae Rhizoma, Cinnabaris, Realgar, Aurum, and Mel and cutting the natural substances into microparticle size or extracting the natural substances with water to form a first product; providing a predetermined quantity of natural substances from the genera Bezoar Bovis, Moschus, and Rhinocerotis; cutting the natural substances into a microparticle size and extracting with water or alcohol to form a second product; providing a genus Gelatin solution; providing a genus Borneol solution; mixing the first and sec
    Type: Grant
    Filed: October 11, 1990
    Date of Patent: March 2, 1993
    Inventor: Young S. Kim
  • Patent number: 5133964
    Abstract: A pharmaceutical liquid composition prepared by combining a predetermined quantity of natural substances from the genera Glycyrrhizae Radix, Ginseng Radix, Typhae Pollen, Massa Medicata Fermentata, Sojae germinatum Semen, Cinnamomi Cortex, Paeoniae Radix, Liriope Tuber, Scutellariae Radix, Angelicae Gigantis Radix, Ledebouriellae Radix, Atractylodis Rhizoma Alba, Bupleuri Radix, Platycodi Radix, Armeniacae Semen, Hoelen, Cnidii Rhizoma, Antellopis Cornu, Ampelopsis Radix, Zingiberis Rhizoma, and Dioscoreae Rhizoma and cutting the natural substances into microparticle size or extracting the natural substances with water or alcohol to form a first microparticle product or extracts; providing a predetermined quantity of natural substances from the genera Bezoar Bovis, Moschus, and Borneol and cutting the natural substances into microparticle size to form a second microparticle product; providing a Gelatin solution; mixing the first microparticle product or extract with the second microparticle product and Gelati
    Type: Grant
    Filed: October 11, 1990
    Date of Patent: July 28, 1992
    Inventor: Young S. Kim
  • Patent number: 5114722
    Abstract: The invention relates to a medicament in the form of a lyophilisate produced from a total extract from Peyer's patches, preferably in homoeopathic dilution. It can be used advantageously for the improvement of the humoral defence system.
    Type: Grant
    Filed: October 31, 1990
    Date of Patent: May 19, 1992
    Inventors: Eugen Zoubek, Heinrich Kehlbeck
  • Patent number: 5104662
    Abstract: The invention relates to a method of encapsulating biologically active substances by gelling them with intestinal mucus (mucin). The invention is also concerned with a capsule produced by the method, its use as a fodder admixture, and a fodder containing such capsules.
    Type: Grant
    Filed: October 16, 1990
    Date of Patent: April 14, 1992
    Assignee: Valio Meijerien Keskusosuusliike
    Inventors: Hannu Kalsta, Eeva-Liisa Syvaoja, Juha Nousiainen, Jouko Setala
  • Patent number: 4990333
    Abstract: Factors isolated from omental extracts are used to promote bone healing, for example in fractures in mammals.
    Type: Grant
    Filed: December 20, 1985
    Date of Patent: February 5, 1991
    Assignees: Angio Medical Corporation, Trustees of Boston University
    Inventors: Joseph Lane, Nicholas Catsimpoolas, Robert S. Sinn
  • Patent number: 4963358
    Abstract: An agent for inhibiting proliferation of human malignant tumor cells is obtained by culturing the human malignant tumor cells in a medium and removing the malignant tumor cells from the cultured medium.
    Type: Grant
    Filed: December 9, 1988
    Date of Patent: October 16, 1990
    Assignees: Koken Ltd., Tadakatsu Oishi, Youichiro Nagasu, Hisao Yamaguchi
    Inventor: Tomoyuki Tajima
  • Patent number: 4962187
    Abstract: A purified common antigen for colorectal and mucinous ovarian cancer (COTA) is provided which is antigenically distinct from CSAp, CEA and Ca 19-9. The COTA antigen is useful for producing a COTA antibody which is nonreactive with CSAp, CEA or Ca 19-9.
    Type: Grant
    Filed: November 21, 1986
    Date of Patent: October 9, 1990
    Assignee: Cota Biotech
    Inventor: Keshab D. Pant
  • Patent number: 4957741
    Abstract: Lipid material or ganglioside from mammalian sources e.g. bovine and porcine brain or omentum is used to treat peptic ulcers.
    Type: Grant
    Filed: August 2, 1988
    Date of Patent: September 18, 1990
    Assignee: Angio-Medical Corp.
    Inventors: Ahmad R. Kamarei, Nicholas Catsimpoolas, Robert McCluer, Takashi Mise, Robert S. Sinn
  • Patent number: 4956178
    Abstract: This invention relates to a method for preparation of a tissue graft composition from a segment of small intestine. A tissue graft composition is described which comprises the tunica submucosa of a segment of small intestine of a warm-blooded vertebrate wherein the tunica submucosa is deliminated from the tunica muscularis and at least the luminal portion of the tunica mucosa. The tissue graft composition has been shown to have excellent mechanical characteristics, as well as non-allergenicity and non-thrombogenicity in applications as vascular autografts, vascular allografts, and vascular heterografts.
    Type: Grant
    Filed: November 6, 1989
    Date of Patent: September 11, 1990
    Assignee: Purdue Research Foundation
    Inventors: Stephen F. Badylak, Leslie A. Geddes, Gary Lantz, Arthur C. Coffey