Liver Patents (Class 424/553)
  • Patent number: 10329553
    Abstract: The present invention provides a method for isolating RNA including small RNA having a size of 200 nt or less from a sample, comprising the following steps: a) providing a composition comprising RNA and a chaotropic agent; b) adding alcohol; c) incubating the mixture for at least 2 min; d) adding additional alcohol to the mixture to adjust the overall alcohol concentration in the mixture to ?50%; e) binding RNA contained in the mixture to a nucleic acid binding solid phase; f) optionally washing the bound RNA; g) optionally eluting RNA from the solid phase. Due to the step-wise addition of alcohol, the overall RNA yield and the yield of small RNA is improved.
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: June 25, 2019
    Assignee: QIAGEN GmbH
    Inventors: Martin Schlumpberger, Stefanie Schröer, Vera Holländer
  • Publication number: 20150135344
    Abstract: The application provides methods of modulating platelet uptake by liver sinusoidal endothelial cells and of modulating thrombocytopenia. Transgenic pigs modified to bind fewer platelets are provided.
    Type: Application
    Filed: September 19, 2014
    Publication date: May 14, 2015
    Inventors: Alfred Joseph Tector, III, Christopher Burlak
  • Publication number: 20150110754
    Abstract: Provided herein are methods for accurately determining the alleles present at a locus that is broadly applicable to any locus, including highly polymorphic loci such as HLA loci, BGA loci and HV loci. Embodiments of the disclosed methods are useful in a wide range of applications, including, for example, organ transplantation, personalized medicine, diagnostics, forensics and anthropology.
    Type: Application
    Filed: October 14, 2014
    Publication date: April 23, 2015
    Inventors: Yu Bai, Wen Fury
  • Publication number: 20150079062
    Abstract: The invention provides a method of harvesting, processing and storing a plurality of proteins from a mammalian feto-placental unit. The method includes dissecting a mammalian uterus to harvest at least one component of the mammalian feto-placental unit; blast freezing the component; and storing the blast frozen component; wherein the blast frozen component includes the proteins. In one embodiment, the method includes lyophilizing the blast frozen component to remove at least some water from the blast frozen component thereby creating a freeze-dried form; and storing the lyophilized component; wherein the lyophilized component includes the proteins. The invention also provides a composition including proteins from at least one lyophilized, blast frozen component of a harvested mammalian feto-placental unit reconstituted with a fluid.
    Type: Application
    Filed: November 24, 2014
    Publication date: March 19, 2015
    Inventors: Patrick J. Casey, Murray Hoare
  • Publication number: 20150079061
    Abstract: The invention provides a method of harvesting, processing and storing a plurality of proteins from a mammalian feto-placental unit. The method includes dissecting a mammalian uterus to harvest at least one component of the mammalian feto-placental unit; blast freezing the component; and storing the blast frozen component; wherein the blast frozen component includes the proteins. In one embodiment, the method includes lyophilizing the blast frozen component to remove at least some water from the blast frozen component thereby creating a freeze-dried form; and storing the lyophilized component; wherein the lyophilized component includes the proteins. The invention also provides a composition including proteins from at least one lyophilized, blast frozen component of a harvested mammalian feto-placental unit reconstituted with a fluid.
    Type: Application
    Filed: July 14, 2014
    Publication date: March 19, 2015
    Inventors: Patrick J. Casey, Murray Hoare
  • Patent number: 8951572
    Abstract: A method of treating a renal, hepatic or enzyme-deficiency disorder in a subject in need thereof is disclosed. The method is effected by transplanting into the subject tissue derived from a human or porcine, kidney or liver, the kidney or liver being at a selected gestational stage.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: February 10, 2015
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Yair Reisner, Benjamin Dekel, Smadar Eventov-Friedman, Helena Katchman, Elias Shezen, Anna Aronovich, Dalit Tchorsh
  • Publication number: 20150030663
    Abstract: A wound dressing composition comprising a non-viable cell lysate or releasate derived from a hepatocyte cell or an inflammatory cell such as a macrophage. Also provided are wound dressings comprising such compositions, methods of making such compositions, and the use of such compositions for the treatment of wounds.
    Type: Application
    Filed: August 13, 2014
    Publication date: January 29, 2015
    Inventors: Rachel Louise Clark, Breda Mary Cullen, Lindsay Matheson
  • Patent number: 8884096
    Abstract: The current invention is related to a method for the production of a human monoclonal antibody from a immunodeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently contacting said reconstituted animal with a antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: November 11, 2014
    Assignees: Bernd Mueller-Beckmann
    Inventors: Alexander Lifke, Valeria Lifke, Bernd Mueller-Beckmann, Tobias Schnitzer
  • Patent number: 8877224
    Abstract: Disclosed herein are compositions and methods for treating or preventing a cardiac arrhythmia in a subject.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: November 4, 2014
    Assignee: CorMatrix Cardiovascular, Inc
    Inventors: Robert G. Matheny, Beecher C. Lewis
  • Publication number: 20140242184
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Application
    Filed: May 5, 2014
    Publication date: August 28, 2014
    Inventor: Robert G Matheny
  • Publication number: 20140242183
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Application
    Filed: May 5, 2014
    Publication date: August 28, 2014
    Inventor: Robert G. Matheny
  • Publication number: 20140227364
    Abstract: The present invention is directed to methods of manufacturing bioactive gels from ECM material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. The manufacturing methods take advantage of a new recognition that bioactive gels from ECM material can be created by digesting particularized ECM material in an alkaline environment and neutralizing to provide bioactive gels.
    Type: Application
    Filed: February 7, 2014
    Publication date: August 14, 2014
    Inventors: Kimberly A. Kentner, Katherine A. Stuart, Abram D. Janis
  • Patent number: 8802436
    Abstract: The present invention is directed to methods of manufacturing bioactive gels from ECM material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. The manufacturing methods take advantage of a new recognition that bioactive gels from ECM material can be created by digesting particularized ECM material in an alkaline environment and neutralizing to provide bioactive gels.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: August 12, 2014
    Assignee: ACell, Inc.
    Inventors: Kimberly A. Kentner, Katherine A. Stuart, Abram D. Janis
  • Publication number: 20140147830
    Abstract: Embodiments include methods for decellularizing an organ or tissue comprising conditioning the organ or tissue to be decellularized by exposing the organ or tissue to an electric current, as well as methods of using such decellularized organs or tissues.
    Type: Application
    Filed: November 29, 2012
    Publication date: May 29, 2014
    Inventor: Omar Barakat
  • Publication number: 20140134264
    Abstract: The invention relates to the use of microvesicles (MVs) derived from stem cells for preparing a medicament for the endo/epithelial regeneration of damaged tissues or organs and/or for inhibiting the apoptosis induced by cytostatic agents. The stem cell from which the microvesicles are obtained is preferably selected from the group consisting of endothelial progenitor cells (EPCs), mesenchimal stem cells (MSCs), renal progenitors CD133+, adult human liver stem cells (HLSC) and any combination thereof. The microvesicles may be used in both in vitro and in vivo applications, such as for example the regeneration of damaged tissues or organs and the treatment of renal injury and hepatic injury, particularly acute renal failure (ARF) and acute hepatic failure (AHF).
    Type: Application
    Filed: December 2, 2013
    Publication date: May 15, 2014
    Applicant: Fresenius Medical Care Deutschland GmbH
    Inventors: Vincenzo CANTALUPPI, Maria Deregibus, Giovanni Camussi
  • Publication number: 20140112890
    Abstract: The invention features the production of an amine-reactive proteoglycan, specifically chondroitin sulfate or hyaluronic acid. This material can be provided in powder (solid) or liquid form and combined with blood derivatives including serum, platelets, platelet rich plasma, bone marrow, or with other tissue products to form hydrogels. The properties (physical and biological) are different for each of these hydrogels and can be further manipulated by controlling the conditions under which the hydrogels are formed. Such properties include the biodegradability of the hydrogel, the compressibility, the adhesive strength, the presence of pharmaceutical agents or therapeutic cells, and resiliency.
    Type: Application
    Filed: April 2, 2012
    Publication date: April 24, 2014
    Applicant: The John Hopkins University
    Inventors: Jennifer H. Elisseeff, Iossif Strehin
  • Publication number: 20140115728
    Abstract: The invention provides double knockout transgenic pigs (GT/CMAH-KO pigs) lacking expression of any functional ?GAL and CMAH. Double knockout GT/CMAH-KO transgenic organs, tissues and cells are also provided. Methods of making and using the GT/CMAH-KO pigs and tissue are also provided.
    Type: Application
    Filed: March 14, 2013
    Publication date: April 24, 2014
    Inventor: A. Joseph Tector
  • Patent number: 8691276
    Abstract: Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.
    Type: Grant
    Filed: November 26, 2012
    Date of Patent: April 8, 2014
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Stephen F. Badylak, Donald Freytes
  • Publication number: 20130236453
    Abstract: Methods and compositions for treating or preventing acute graft-versus-host disease (aGVHD) in a subject using miR-155 specific inhibitors are described.
    Type: Application
    Filed: March 12, 2013
    Publication date: September 12, 2013
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, Ramiro Garzon
  • Publication number: 20130129833
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Application
    Filed: January 2, 2013
    Publication date: May 23, 2013
    Inventor: Robert G. Matheny
  • Publication number: 20130078314
    Abstract: The present invention is about a transdermal method that deliveries nutrients from fresh animal organs to the systemic circulation of the human body by applying the juice or chopped pieces of the fresh animal organs on the skin of the human body and allowing the nutrients to absorb through the layers of the exposed skin. The present invention aims to preserve the Yin and Yang energies naturally present in fresh organs and other foods that are lost in cooking and processing of foods. The present invention uses the full skin area transdermal delivery method by soaking the whole body in the juice of the fresh animal organs as well as the partial skin area transdermal delivery method by exposing certain parts of the human skin area to the fresh juices or chopped fresh animal organs and allowing the nutrients to enter the systemic circulation of the human body.
    Type: Application
    Filed: March 16, 2012
    Publication date: March 28, 2013
    Inventor: Peter Chan
  • Patent number: 8361503
    Abstract: Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: January 29, 2013
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Stephen F. Badylak, Donald O. Freytes
  • Publication number: 20120321723
    Abstract: The invention is in the field of therapeutic treatment of tumours. The inventors have found that microvesicles derived from adult stem cells exert a remarkable anti-tumour effect when administered to a patient affected by a tumour disease. Preferred microvesicles are derived from a bone marrow-mesenchymal stem cell, a glomerular mesenchymal stem cell or a non-oval liver stem cell.
    Type: Application
    Filed: February 28, 2011
    Publication date: December 20, 2012
    Applicant: FRESENIUS MEDICAL CARE DEUTSCHLAND G.M.B.H.
    Inventors: Stefania Bruno, Maria Herrera Sanchez, Valentina Fonsato, Giovanni Camussi, Ciro Tetta
  • Publication number: 20120251507
    Abstract: Disclosed herein are compositions and methods for treating or preventing a cardiac arrhythmia in a subject.
    Type: Application
    Filed: May 24, 2012
    Publication date: October 4, 2012
    Applicant: CORMATRIX CARDIOVASCULAR, INC.
    Inventors: ROBERT G. MATHENY, Beecher C. Lewis
  • Publication number: 20120225056
    Abstract: The present disclosure relates to, inter alia, compositions containing an inhibitor of human complement and use of the compositions in methods for treating or preventing complement-associated disorders. In some embodiments, the inhibitor is chronically administered to patients. In some embodiments, the inhibitor is administered to a patient in an amount and with a frequency to maintain systemic complement inhibition and prevent breakthrough. In some embodiments, the compositions contain an antibody, or antigen-binding fragment thereof, that binds to a human complement component C5 protein or a fragment of the protein such as C5a or C5b.
    Type: Application
    Filed: November 10, 2009
    Publication date: September 6, 2012
    Applicant: Alexion Pharmaceuticals, Inc.
    Inventors: Russell P. Rother, Camille Bedrosian, Stephen P. Squinto, Leonard Bell
  • Publication number: 20120225018
    Abstract: The present invention relates to compositions including a homeopathic aqueous substance active (HASA) and at least one hydrophilic gelling agent, the HASA comprises a homeopathic compound at a potency of 30 C or higher and an uninhibited aqueous composition. The present invention also relates to methods of preparing a hydrophilic HASA-gel matrix. The method includes combining a homeopathic compound and an uninhibited aqueous composition to produce a HASA; combining the HASA with at least one hydrophilic gelling agent; and thereafter, forming the hydrophilic HASA-gel matrix by use of at least one of a thickening agent, a crosslinking agent, or a polymerization agent.
    Type: Application
    Filed: March 2, 2012
    Publication date: September 6, 2012
    Inventor: Nancy Josephine Polich
  • Patent number: 8236354
    Abstract: A method for treating a cancer, by determining a patient to have an ECOG (Eastern Cooperative Oncology Group) score of 0 or 1 and selecting that patient for treatment, and administering to the patient an effective amount of an immunomodulating composition comprising small molecular weight components of less than 3000 daltons, and having the following properties: (i) is extracted from bile of animals; (ii) is capable of stimulating monocytes and/or macrophages; (iii) is capable of modulating tumor necrosis factor production and/or release; (iv) contains no measurable level of IL-1?, IL-1?, TNF, IL-6, IL-8, IL-4, GM-CSF or IFN-?; (v) is not cytotoxic to human peripheral blood mononuclear cells; and (vi) is not an endotoxin.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: August 7, 2012
    Assignee: ZOR Pharmaceuticals, LLC
    Inventors: Daniel Tyree Gregory, Jr., Stephan Dale Glenn, Asher Nathan
  • Publication number: 20120121680
    Abstract: Deicing products designed to deter ungulates are provided, along with methods of using those products to treat iced surfaces. The deicing product comprises a mixture of a deicer along with an ungulate repellent. The repellent can repel based on conditioned avoidance, fear, chemical irritation, and/or bad taste. The deicer can be a salt or a deicer solution. The invention is useful for deterring any ungulate that might be attracted to a component of the deicing product (e.g., the salt), but it is particularly useful for deterring deer.
    Type: Application
    Filed: October 18, 2011
    Publication date: May 17, 2012
    Applicant: NORTH AMERICAN SALT COMPANY
    Inventors: Neil Alexander Rosenburgh, Michelle Lee Daum, Jason Louis Bagley, Dan Pannell, Kristopher Shelite
  • Publication number: 20120070507
    Abstract: Provided herein are compositions and methods for the treatment of soft tissue injury, sports-related injury, physical overuse of muscles, ligaments or joints, and trauma, traumatic stress or sudden jolts on bones and tissues in an individual. Described herein are pharmaceutical compositions comprising a vasoconstrictor and, optionally, a topical analgesic and methods of using said compositions for the treatment of a variety of soft tissue injuries.
    Type: Application
    Filed: September 17, 2010
    Publication date: March 22, 2012
    Applicant: MATRILINEX LLC
    Inventors: Corinna HOWELL, Neil HOWELL
  • Publication number: 20110305772
    Abstract: The invention provides compositions and methods for delivery of nucleic acids to the liver ex vivo. The method includes slow, low pressure infusion of the nucleic acid into the liver to efficiently transduce cells with minimal cell damage.
    Type: Application
    Filed: February 26, 2010
    Publication date: December 15, 2011
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventor: Andrew M. Cameron
  • Patent number: 8003131
    Abstract: A tissue graft composition comprising liver basement membrane is described. The graft composition can be implanted to replace or induce the repair of damaged or diseased tissues.
    Type: Grant
    Filed: January 6, 2009
    Date of Patent: August 23, 2011
    Assignee: Purdue Research Foundation
    Inventor: Stephen F. Badylak
  • Publication number: 20110117191
    Abstract: The invention relates to a substance mixture on the basis of a mixture of essential oils, wherein the oil mixture contains juniper oil and turpentine oil, in particular turpentine oil of the duster pine type or substantially comprises them, and wherein the substance mixture preferably furthermore contains a liquid and/or dissolved active ingredient or a mixture of a plurality thereof and/or an active ingredient in powder form or a mixture of a plurality thereof.
    Type: Application
    Filed: October 13, 2010
    Publication date: May 19, 2011
    Inventor: Marianne Brøndlund
  • Publication number: 20110083201
    Abstract: The present invention is related to the discovery that serpina3n, a secreted protein, binds to and inhibits granzyme B activity. The invention thus provides cells that include a polynucleotide encoding a granzyme B inhibitory serpin, pharmaceutical compositions including a granzyme B inhibitory serpin or a polynucleotide encoding a granzyme B inhibitory serpin, methods for treating a patient in need of immunosuppression by administration of a granzyme B inhibitory serpin, and methods of transplanting cells (e.g., islet cells) expressing a granzyme B inhibitory serpin.
    Type: Application
    Filed: September 7, 2010
    Publication date: April 7, 2011
    Inventors: Ray V. Rajotte, R. Chris Bleackley, Greg Korbutt, Sarah J. Lord, Simonetta Sipione, Katia Carmine-Simmen, Fabrizio Giuliani
  • Patent number: 7919121
    Abstract: A tissue graft composition comprising liver basement membrane and a method of preparation of this tissue graft composition are described. The graft composition can be implanted to replace or induce the repair of damaged or diseased tissues.
    Type: Grant
    Filed: January 9, 2003
    Date of Patent: April 5, 2011
    Assignee: Purdue Research Foundation
    Inventors: Stephen Francis Badylak, Eric James Rodenberg
  • Publication number: 20100285147
    Abstract: Provided an acidic liquid preparation containing a herb and/or animal-origin extract at high concentration to suppress time-dependent occurrence of precipitation and/or opacity. A liquid preparation containing a herb-origin extract having pH of 3.0 to 5.5 and containing the herb-origin extract at a concentration of 5 to 50 w/v % (dry weight) to the total amount of the liquid preparation, containing a caramel at a concentration of 0.5 to 20 w/v % to the total amount of the liquid preparation, wherein the caramel has isoelectric point of 2.5 to 4.0 and 1.0 w/v % aqueous solution of the caramel has pH of 4.5 to 6.0. A liquid preparation containing an animal-origin extract having pH of 3.0 to 5.5 and containing the animal-origin extract at concentration of 5 to 50 w/v % (dry weight) to the total amount of the liquid preparation, containing a caramel at concentration of 0.5 to 20 w/v % to the total amount of the liquid preparation, wherein the caramel has isoelectric point of 0.5 to 4.0 and 1.
    Type: Application
    Filed: July 31, 2008
    Publication date: November 11, 2010
    Applicant: WAKUNAGA PHARMACEUTICAL CO. LTD
    Inventors: Soko Motoune, Mizuho Ono, Junichiro Wakamatsu, Shiho Kano, Yoichi Ikeda
  • Publication number: 20100209481
    Abstract: A wound dressing composition comprising a non-viable cell lysate or releasate derived from a hepatocyte cell or an inflammatory cell such as a macrophage. Also provided are wound dressings comprising such compositions, methods of making such compositions, and the use of such compositions for the treatment of wounds.
    Type: Application
    Filed: November 2, 2007
    Publication date: August 19, 2010
    Applicant: SYSTAGENIX WOUND MANAGEMENT (US) INC.
    Inventors: Rachael Louise Clark, Breda Mary Cullen, Lindsay Matheson
  • Publication number: 20090232784
    Abstract: Compositions and processes for promoting wound healing are provided by the present invention which increase the rate and completeness of wound healing. Broadly described, an inventive composition includes a degradable scaffold of biocompatible material and a cell involved in wound healing, or a predecessor of such a cell, disposed in contact with the scaffold. In one embodiment, an albumin scaffold is provided with an endothelial cell predecessor disposed therein. Optionally, a cell involved in wound healing or a predecessor of such a cell is administered by local or systemic injection in conjunction with application of an inventive composition. Processes for promoting wound healing are provided as well as processes for producing the described compositions for promoting healing.
    Type: Application
    Filed: March 10, 2006
    Publication date: September 17, 2009
    Inventors: Dale Feldman, Jennifer McCullars, Jerry Blackwell
  • Publication number: 20090180965
    Abstract: The invention is directed to a method for treating a tissue or organ in a subject by directly administering an effective amount of an exogenous, decellularized extracellular matrix or a mixture of extracellular matrix and mesenchymal stem cells into the intended site of activity, such as bone marrow cavity. In one embodiment, the invention provides methods of treating bone marrow to increase the number of circulating progenitor and stem cells. In some other embodiments of the invention, the decellularized extracellular matrix to be directly administered is configured to be a time released therapeutic.
    Type: Application
    Filed: January 2, 2009
    Publication date: July 16, 2009
    Applicant: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Toby M. Freyman, Wendy Naimark, Maria Palasis
  • Patent number: 7482025
    Abstract: A tissue graft composition comprising liver basement membrane is described. The graft composition can be implanted to replace or induce the repair of damaged or diseased tissues.
    Type: Grant
    Filed: February 10, 2004
    Date of Patent: January 27, 2009
    Assignee: Purdue Research Foundation
    Inventor: Stephen F. Badylak
  • Publication number: 20080260853
    Abstract: The invention an article or composition of mammalian extracellular matrix (ECM) for placement in a lumpectomy space of a breast after tumor removal. The extracellular matrix article or composition can regenerate lost breast tissue, reduce the formation of scar tissue at the site of excision, and reduce a likelihood of local tumor recurrence at the lumpectomy site. The article can be sheet ECM, and the composition can be particulate ECM or emulsion or gel ECM.
    Type: Application
    Filed: October 23, 2007
    Publication date: October 23, 2008
    Inventor: LEIGH H. FIRESTONE
  • Publication number: 20080260831
    Abstract: Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.
    Type: Application
    Filed: February 29, 2008
    Publication date: October 23, 2008
    Inventors: Stephen F. Badylak, Donald O. Freytes
  • Publication number: 20080254139
    Abstract: The invention is a method of treating ovarian cancer by contacting a post-surgical site of an ovarian cancer patient with a composition or a sheet article comprising extracellular matrix to inhibit cancer cell attachment, promote wound healing after the surgery, reduce scar formation at the surgical site, regenerate lost tissue, and prevent tumor recurrence at the site or in the peritoneum generally.
    Type: Application
    Filed: October 27, 2007
    Publication date: October 16, 2008
    Inventor: LEIGH H. FIRESTONE
  • Publication number: 20080213388
    Abstract: Methods are described for using exogenous extracellular matrix (ECM) to fill a space created after cancerous tumor excision. The extracellular matrix promotes healing at the tumor excision site. Forms of ECM that can be used include exogenous mammalian ECM in sheets, particulate and emulsion.
    Type: Application
    Filed: May 11, 2008
    Publication date: September 4, 2008
    Inventor: Leigh H. Firestone
  • Patent number: 6911220
    Abstract: The invention provides methods for restoring or inducing immunocompetence, the methods including the step of introducing donor thymic tissue into the recipient. The invention also provides methods for inducing tolerance in a recipient including introducing donor thymic tissue into the recipient. The invention further provides methods of inducing tolerance including administering to the recipient a short course of help reducing treatment or administering a short course and methods of prolonging the acceptance of a graft by administering a short course of an immunosuppressant.
    Type: Grant
    Filed: November 9, 2000
    Date of Patent: June 28, 2005
    Assignee: The General Hospital Corporation
    Inventor: David H. Sachs
  • Publication number: 20040191226
    Abstract: A method for inducing the repair of damaged or diseased body wall tissues is provided. In one embodiment, damaged or diseased body wall tissue is replaced with basement membranes of a warm-blooded vertebrate to promote regrowth of body wall tissues to form a multilaminate structure.
    Type: Application
    Filed: December 4, 2003
    Publication date: September 30, 2004
    Inventor: Stephen F. Badylak
  • Patent number: 6793939
    Abstract: A tissue graft composition comprising liver basement membrane is described. The graft composition can be implanted to replace or induce the repair of damaged or diseased tissues.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: September 21, 2004
    Assignee: Purdue Research Foundation
    Inventor: Stephen F. Badylak
  • Patent number: 6696094
    Abstract: The present invention provides a pharmaceutical composition for treating patients with HIV infection. The pharmaceutical composition is in the form of an intravenous injection solution and optionally capsules. The pharmaceutical composition contains fourteen (14) ingredients, i.e., diffuse hedyotis, bistort rhizome, giant knotweed rhizome, Asiatic moonseed rhizome, baical skullcap root, bovine biliary powder, milkvetch root, barbary wolfberry fruit, sanqi, figwort root, Chinese magnoliavine fruit, turmeric root-tuber, hawthorn fruit, and Chinese angelica.
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: February 24, 2004
    Inventor: Tzu-Sheng Wu
  • Patent number: 6652846
    Abstract: The invention relates to attractants for use in yellow jacket traps. The attractants have improved overall effectiveness in attracting yellow jackets, in attracting a broader spectrum of yellow jacket species and in attracting yellow jackets in the several phases of their life cycles when their food requirements vary. The attractants are distinguished by the inclusion of a weak acid in the attractant formulation. The preferred weak acid is acetic acid and its preferred form is a vinegar.
    Type: Grant
    Filed: December 7, 2000
    Date of Patent: November 25, 2003
    Inventor: Roger H. Long
  • Publication number: 20030118663
    Abstract: A therapeutic composition for treating diabetes includes mixing of the following ingredients:
    Type: Application
    Filed: December 24, 2001
    Publication date: June 26, 2003
    Inventor: Ching-Ming Chang
  • Publication number: 20020160052
    Abstract: A tissue graft composition comprising liver basement membrane is described. The graft composition can be implanted to replace or induce the repair of damaged or diseased tissues.
    Type: Application
    Filed: April 29, 2002
    Publication date: October 31, 2002
    Inventor: Stephen F. Badylak