Adipose Or Epithelium Patents (Class 424/574)
  • Patent number: 10821206
    Abstract: Method of the osteoreparative processes' correction and/or bone defect restoration by means of human cell-based products (cell and/or tissue transplants) and the method of its manufacturing. The invention a creates and establishes conditions for osteoreparative processes restoration in destroyed bone tissue by osteoreparation cell sources restoration as the result of use cell technologies and bone tissue engineering methods, e.g. scaffold-guided regeneration, particularly by means of cell transplantation by injection and/or transplantation of original three-dimensional osteoreparative prevascularized graft (3D-OPG). Manufacturing of medical products and preparations of the product based on human cells (cell and/or tissue transplants) is dedicated for impaired osteoreparative processes correction and/or bone defect restoration.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: November 3, 2020
    Assignee: ILAYA USA CORPORATION
    Inventors: Volodymyr Mykhaylovych Oksymets, Dmytro Oleksandrovych Zubov, Roman Hennadiyovych Vasyliev
  • Patent number: 10801009
    Abstract: The present invention relates to: a cosmetic composition for improving the condition of the skin, containing, as active ingredients, a cell culture medium, an epidermal growth factor and a bovine serum albumin; a method for improving the condition of the skin by using the same; and a method for preventing or treating skin diseases. According to the present invention, the cosmetic composition can exhibit excellent wrinkle-reducing and wound-healing effects even when only a small amount of EGF is used, and thus can be useful in improving the condition of the skin or in preventing or treating skin diseases.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: October 13, 2020
    Assignee: BIOCOZ GLOBAL KOREA CORP.
    Inventors: Chan Wha Kim, Young Joon Kim, Hyun Jung Kim
  • Patent number: 10564114
    Abstract: Alternatives described herein relate to methods for detecting, identifying, and/or diagnosing eating disorders, nutritional deficiencies, and/or malnutrition, including conditions such as bulimia nervosa and/or anorexia nervosa, by using X-ray diffraction on a sample of a tested subject's hair. In some alternatives, once an eating disorder, nutritional deficiency, or malnutrition is detected, identified, or diagnosed using the X-ray diffraction approaches set forth herein, a subject identified as having an eating disorder, nutritional deficiency, or malnutrition is provided counseling for the disorder and/or a medicament to treat, inhibit, or ameliorate said eating disorder or malnutrition, including Prozac, ami trip tyline, fluoxe tine, imipramine, Nardil, Tofranil, desipramine, Sarafem, Norpramin, and/or phenelzine.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: February 18, 2020
    Assignee: STRUCTURE-ASE INCORPORATED
    Inventors: Steven Richard Herron, Kent Hatch, Savannah Marriott, Diane Spangler
  • Patent number: 10426802
    Abstract: A sheet-shaped cell culture and method for producing a sheet-shaped cell culture are disclosed having a high activity such as high cytokine productivity and a production method thereof. The method for producing a sheet-shaped cell culture can include freezing cells, thawing the frozen cells and forming a sheet-shaped cell culture. A sheet-shaped cell culture which is produced by the production method and which has a high activity and a method for treating a disease associated with an abnormality of a tissue with the sheet-shaped cell culture.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: October 1, 2019
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Kenta Sakamoto, Kouichirou Yori
  • Patent number: 10091983
    Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for cryopreserving viable skin substitutes.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: October 9, 2018
    Assignee: Stratatech Corporation
    Inventors: B. Lynn Allen-Hoffmann, John C. Pirnstill, Kenneth R. Gratz, Allen R. Comer
  • Patent number: 9907745
    Abstract: The present invention generally relates to cosmetic compositions comprising serum derived from cultured keratinocyte and fibroblast cells. The invention also relates to methods of producing serum for use in the cosmetic compositions through novel cell culture techniques.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: March 6, 2018
    Assignee: SERUCELL CORPORATION
    Inventor: Walter De Paula Neto
  • Patent number: 9446189
    Abstract: Devices and methods for tissue transfer are described where a cannula may be inserted into the breast of a subject at one of several points of entry. Insertion of the cannula into the breast may be accomplished by using a guidance system to distinguish between tissue types. Once desirably positioned, the cannula may be withdrawn from the breast while automatically (or manually) injecting the fat in multiple deposits of adipose tissue or fat such that the deposited fat remains within the tract formed by the withdrawn cannula. Multiple tracts of the deposited fat may be injected within the breast until the breast has been desirably remodeled and/or augmented.
    Type: Grant
    Filed: January 16, 2013
    Date of Patent: September 20, 2016
    Assignee: LifeCell Corporation
    Inventors: Joseph Rimsa, Brian J. Domecus, Christopher S. Jones, Paul James Lingane
  • Publication number: 20150147409
    Abstract: A combination of therapeutic factors derived from non-adherent or poorly adherent stromal vascular fraction (SVF) cells exposed to protein-free basal medium are disclosed.
    Type: Application
    Filed: November 21, 2014
    Publication date: May 28, 2015
    Inventors: Keith L. March, Brian H. Johnstone
  • Patent number: 9005605
    Abstract: The specification discloses compositions and methods for treating a soft tissue defect of an individual.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: April 14, 2015
    Assignee: Allergan, Inc.
    Inventors: Dennis E. Van Epps, Guang-Liang Jiang, Wha Bin Im
  • Publication number: 20150064147
    Abstract: Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a collagen component.
    Type: Application
    Filed: November 6, 2014
    Publication date: March 5, 2015
    Applicant: Allergan, Inc.
    Inventors: Jacob F. Pollock, Lauren E. Kokai, CUNQI Cui, Xiaojie Yu, Dennis E. Van Epps, Darin J. Messina
  • Publication number: 20150064273
    Abstract: Mesenchymal stem cell conditioned medium and methods for preparing the conditioned medium are provided. The methods comprise culturing MSCs in a medium comprising nicotinamide or nicotinamide and fibroblast growth factor 4 (FGF4) and collecting the conditioned medium. Compositions comprising the mesenchymal stem cell conditioned medium and uses thereof are also provided.
    Type: Application
    Filed: February 13, 2013
    Publication date: March 5, 2015
    Inventors: Tony Peled, Yair Steinhardt
  • Patent number: 8962035
    Abstract: Disclosed are tissue graft compositions made of materials having different densities, methods of making, and methods of treatment for restoring tissues in a patient.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: February 24, 2015
    Assignee: ACell, Inc.
    Inventors: Rodney W. Bosley, Jr., Clay Fette
  • Publication number: 20150037436
    Abstract: An acellular soft tissue-derived matrix includes a collagenous tissue that has been delipidated and decellularized. Adipose tissue is among the soft tissues suitable for manufacturing an acellular soft tissue-derived matrix. Exogenous tissuegenic cells and other biologically-active factors may be added to the acellular matrix. The acellular matrix may be provided as particles, a slurry, a paste, a gel, or in some other form. The acellular matrix may be provided as a three-dimensional scaffold that has been reconstituted from particles of the three-dimensional tissue. The three-dimensional scaffold may have the shape of an anatomical feature and serve as a template for tissue repair or replacement. A method of making an acellular soft tissue-derived matrix includes steps of removing lipid from the soft tissue by solvent extraction and chemical decellularization of the soft tissue.
    Type: Application
    Filed: July 30, 2014
    Publication date: February 5, 2015
    Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATION
    Inventors: Yen-Chen Huang, Asia Ivery, Bryan Choi, Benjamin Schilling, Manh-Dan Ngo
  • Publication number: 20150037435
    Abstract: Provided are a culture medium of an adipose-derived stem cell, a method for preparing the same, and a composition for promoting hair growth, in which the composition includes the culture medium. The adipose-derived stem cell (ADSC-T) according to the present invention exhibits long lifespan, improved cell proliferation rate, and extended proliferation period, as compared with a primary adipose-derived stem cell (ADSC), and thus, the adipose-derived stem cell (ADSC-T) can be usefully used for the study about the adipose-derived stem cell and the mass production of the culture medium of the adipose-derived stem cell. In addition, according to the present invention, the culture medium of the adipose-derived stem cell (ADSC-T) that expresses a T antigen of SV40 exhibits excellent hair growth effectiveness and can be usefully used as a raw material for the hair loss prevention and hair growing agents.
    Type: Application
    Filed: August 29, 2012
    Publication date: February 5, 2015
    Inventors: Dong Wan Kim, Mi Jung Seo, Gwang Lee, Woo Hong Joo, Sun Hee Kim
  • Publication number: 20150017254
    Abstract: Methods for treating a cardiovascular disorder comprising concomitant administration of one or more extracellular matrix (ECM) based compositions directly to damaged or diseased cardiovascular tissue associated with the cardiovascular disorder, and provision of ventricular assistance. In a preferred embodiment, the ECM based compositions include an ECM material derived from a mammalian source.
    Type: Application
    Filed: June 11, 2013
    Publication date: January 15, 2015
    Inventors: Robert G. Matheny, Anna Fallon
  • Publication number: 20140255507
    Abstract: The synthesis of collagen and proteoglycan in chondrocytes, such as intervertebral disc cells, articular chondrocytes and meniscal cells is promoted by administration of an extract from inflamed tissue inoculated with vaccinia virus.
    Type: Application
    Filed: October 11, 2011
    Publication date: September 11, 2014
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NIPPON ZOKI PHARMACEUTICAL CO., LTD.
    Inventors: Koichi Masuda, Mitsuru Naiki
  • Publication number: 20140234272
    Abstract: The invention relates to compositions comprising (i) adipose tissue-derived cell secretions or (ii) an adipose tissue-derived cell suspension, optionally comprising adipocytes, or (iii) a combination of adipose tissue-derived cell secretions and an adipose tissue-derived cell suspension, optionally comprising adipocytes, and to their use in pharmaceutical compositions and methods for treatment of various conditions. The invention also relates to improved methods, agents and compositions for cryopreservation of cells.
    Type: Application
    Filed: September 21, 2012
    Publication date: August 21, 2014
    Applicant: Cell Ideas Pty Ltd.
    Inventors: Graham Vesey, Rebecca Anne Webster, Richard Lilischkis
  • Publication number: 20140170234
    Abstract: The present specification discloses compositions and methods of transplanting tissue, for example, in breast augmentation procedures. The compositions include adipose tissue and compounds that reduce tissue volume loss and increase survival rate of the adipose tissue when the composition is introduced into breast tissue.
    Type: Application
    Filed: February 25, 2014
    Publication date: June 19, 2014
    Applicant: Allergan, Inc.
    Inventors: Dennis E. Van Epps, Guan-Liang Jiang, Wha Bin Im
  • Publication number: 20140170233
    Abstract: The invention relates to a natural feed mixture for breeding domesticated water birds, comprising a high carbohydrate containing basic component poor in methyl-donors, a component rich in carbohydrates, having hepatic insulin-sensitizing properties, hypothalamic appetite-stimulating plant parts, natural substances blocking cholesterol synthesis in the liver, and an additive for protecting the formation of non-cholesterol- mevalonate products.
    Type: Application
    Filed: December 17, 2013
    Publication date: June 19, 2014
    Applicant: LIBAFOOD TECH Kft.
    Inventors: Zoltán SZILVÁSSY, Péter TÓTH, Enikö FÖLDI, Zsolt Tibor LAMPÉ, József MÉSZÁROS, Pál ANTON
  • Patent number: 8753690
    Abstract: Methods and compositions generating and using an interleukin-1 receptor antagonist (IL-1ra)-rich solution. Methods for generating and isolating interleukin-1 receptor antagonist include incubating adipose tissue and/or adipocytes with polyacrylamide beads to produce interleukin-1 receptor antagonist. The interleukin-1 receptor antagonist is isolated from the polyacrylamide beads to obtain the solution rich in interleukin-1 receptor antagonist. Methods for treating a site of inflammation in a patient include administering to the site of inflammation the solution rich in interleukin-1 receptor antagonist.
    Type: Grant
    Filed: August 27, 2009
    Date of Patent: June 17, 2014
    Assignee: Biomet Biologics, LLC
    Inventors: Joel C. Higgins, Jennifer E. Woodell-May, Jacy Hoeppner
  • Patent number: 8741281
    Abstract: The specification discloses compositions and methods for treating a soft tissue defect of an individual.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: June 3, 2014
    Assignee: Allergan, Inc.
    Inventors: Dennis E. Van Epps, Guang-Liang Jiang, Adam L. Collette, Rebecca L. Horan, Jingsong Chen, Gregory H. Altman, Wha Bin Im
  • Publication number: 20140140950
    Abstract: Business methods, processes and systems for collection, storage and distribution of a biological sample material for producing a cosmetic formulation product.
    Type: Application
    Filed: March 27, 2012
    Publication date: May 22, 2014
    Inventors: John S. Arnone, Ensley Burt
  • Publication number: 20140134264
    Abstract: The invention relates to the use of microvesicles (MVs) derived from stem cells for preparing a medicament for the endo/epithelial regeneration of damaged tissues or organs and/or for inhibiting the apoptosis induced by cytostatic agents. The stem cell from which the microvesicles are obtained is preferably selected from the group consisting of endothelial progenitor cells (EPCs), mesenchimal stem cells (MSCs), renal progenitors CD133+, adult human liver stem cells (HLSC) and any combination thereof. The microvesicles may be used in both in vitro and in vivo applications, such as for example the regeneration of damaged tissues or organs and the treatment of renal injury and hepatic injury, particularly acute renal failure (ARF) and acute hepatic failure (AHF).
    Type: Application
    Filed: December 2, 2013
    Publication date: May 15, 2014
    Applicant: Fresenius Medical Care Deutschland GmbH
    Inventors: Vincenzo CANTALUPPI, Maria Deregibus, Giovanni Camussi
  • Publication number: 20140112890
    Abstract: The invention features the production of an amine-reactive proteoglycan, specifically chondroitin sulfate or hyaluronic acid. This material can be provided in powder (solid) or liquid form and combined with blood derivatives including serum, platelets, platelet rich plasma, bone marrow, or with other tissue products to form hydrogels. The properties (physical and biological) are different for each of these hydrogels and can be further manipulated by controlling the conditions under which the hydrogels are formed. Such properties include the biodegradability of the hydrogel, the compressibility, the adhesive strength, the presence of pharmaceutical agents or therapeutic cells, and resiliency.
    Type: Application
    Filed: April 2, 2012
    Publication date: April 24, 2014
    Applicant: The John Hopkins University
    Inventors: Jennifer H. Elisseeff, Iossif Strehin
  • Patent number: 8697056
    Abstract: The present specification discloses compositions and methods of transplanting tissue useful for treating a soft tissue condition of an individual.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: April 15, 2014
    Assignee: Allergan, Inc.
    Inventors: Dennis E. Van Epps, Guang-Liang Jiang, Wha Bin Im
  • Patent number: 8697057
    Abstract: The specification discloses compositions and methods for treating a soft tissue defect of an individual.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: April 15, 2014
    Assignee: Allergan, Inc.
    Inventors: Dennis E. Van Epps, Guang-Liang Jiang, Wha Bin Im
  • Patent number: 8697059
    Abstract: The present specification discloses compositions and methods for use in breast augmentation procedures. The compositions include adipose tissue and compounds that upregulate both FGF-2 and VEGF, promote new blood vessel formation thereby reducing tissue volume loss and increasing survival rate of the adipose tissue when the composition is introduced into breast tissue.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: April 15, 2014
    Assignee: Allergan, Inc.
    Inventors: Dennis Van Epps, Guang-Liang Jiang, Wha Bin Im
  • Publication number: 20140088339
    Abstract: Methods for treating a cardiovascular disorder comprising concomitant administration of one or more extracellular matrix (ECM) based compositions directly to damaged or diseased cardiovascular tissue associated with the cardiovascular disorder, and provision of ventricular assistance. In a preferred embodiment, the ECM based compositions include an ECM material derived from a mammalian source.
    Type: Application
    Filed: March 1, 2013
    Publication date: March 27, 2014
    Applicant: Francis Law Group
    Inventor: Robert Matheny
  • Publication number: 20140087001
    Abstract: The present invention relates to methods for the preparation of compositions comprising adipose tissue-derived secretions, for example those derived from bovine adipose tissue, and the use of such compositions in the preparation of a pharmaceutical composition for topical use. The invention also relates to the use of adipose tissue-derived secretions and pharmaceutical compositions thereof for the topical treatment of a non-inflammatory condition, for example the treatment of a skin condition, and for the stimulation of hair growth in a subject by topical application. The invention also relates to the use of adipose tissue-derived secretions and pharmaceutical compositions thereof for the topical treatment of acne.
    Type: Application
    Filed: March 15, 2012
    Publication date: March 27, 2014
    Inventors: Graham Vesey, Rebecca Anne Webster
  • Publication number: 20140079802
    Abstract: Methods to treat nervous system conditions. In at least one embodiment of a method of treating a mammalian patient having a neuronal injury or insult of the present disclosure, the method comprises the step of administering a therapeutically-effective dose of a stem cell conditioned medium to a mammalian patient, the stem cell conditioned medium comprising a cell culture supernatant containing at least one factor capable of exerting effective neuroprotection to treat a mammalian neural injury or insult.
    Type: Application
    Filed: September 5, 2013
    Publication date: March 20, 2014
    Inventors: Keith Leonard March, Brian H. Johnstone, Yansheng Du
  • Publication number: 20140072650
    Abstract: Disclosed is an antihypertensive composition containing as an active ingredient a gelatin extract made from the skins of a skate ray and a peptide isolated from the extract. The present invention is directed to a pharmaceutical composition for a hypertension prevention and therapy containing as an active ingredient a hydrolysate of a gelatin extract isolated from the skins of a skate ray, a method for preparing a hydrolysate of a gelatin extract made from the skins of a skate ray, and the use of a new peptide having an antihypertensive activity isolated and purified from the hydrolysate.
    Type: Application
    Filed: October 31, 2012
    Publication date: March 13, 2014
    Applicant: Pukyong National University Industry-University Cooperation Foundation
    Inventors: Se-Kwon KIM, Bo-Mi RYU
  • Publication number: 20140065238
    Abstract: The invention provides methodologies and apparatus for producing acellular soft-tissue implants, both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. An acellular graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, followed by inducing a pressure mediated flow of a treating solution, then washing the treated tissue to produce the acellular graft. The acellular grafts produced are uniform and nonimmunogenic. The inventive method allows for the production of multiple decellularized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes. In clinical use, the decellularized grafts produced exhibit significantly improved in long-tem durability and function.
    Type: Application
    Filed: October 31, 2013
    Publication date: March 6, 2014
    Applicant: LifeNet Health
    Inventors: Lloyd Wolfinbarger, JR., Peny Lange, Alyce Linthurst-Jones, Eric Moore, Barry Naif
  • Publication number: 20140023622
    Abstract: Methods of developing and using cell lines, such as stem cell lines, for therapeutic or cosmetic use. In one embodiment the cell lines are used to treat a wide range of degenerative and metabolic disorders including, but not limited to, obesity, diabetes, hypertension, and cardiac deficiency. Also described are methods of using such cell lines to screen for compounds that play a role in regulating a variety of processes.
    Type: Application
    Filed: July 1, 2013
    Publication date: January 23, 2014
    Inventors: Francisco Javier Silva, Mark Weinreb, Amit N. Patel, David A. Bull
  • Publication number: 20140017311
    Abstract: A dried product of an extract from inflammatory rabbit skin inoculated with vaccinia virus having an inhibitory activity for the production of a kallikrein-like substance is produced by admixing the extract with a saccharide, sugar alcohol or ascorbic acid before reaching dryness, and then drying the admixture to a solid form such as granules. The dried product may be employed to produce a solid preparation for oral administration, such as tablets, having an inhibitory activity for the production of a kallikrein-like substance.
    Type: Application
    Filed: September 19, 2013
    Publication date: January 16, 2014
    Applicant: NIPPON ZOKI PHARMACEUTICAL CO., LTD.
    Inventors: Masaharu KUROHASHI, Yoji SHIBAYAMA
  • Publication number: 20140004206
    Abstract: Compositions and methods useful in the reduction of localized fat deposits and tightening of loose skin in subjects in need thereof using pharmacologically active detergents are disclosed. The pharmacologically active detergent compositions can additionally include anti-inflammatory agents, analgesics, dispersion or anti-dispersion agents and pharmaceutically acceptable excipients. The pharmacologically active detergent compositions are useful for treating localized accumulations of fat including, for example, lower eyelid fat herniation, lipodystrophy and fat deposits associated with cellulite and do not require surgical procedures such as liposuction.
    Type: Application
    Filed: June 13, 2013
    Publication date: January 2, 2014
    Applicants: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Michael S. Kolodney, Adam M. Rotunda
  • Patent number: 8613957
    Abstract: A scaffold material for wound care and/or other tissue healing applications and methods for making the same is described. The scaffold material is constituted of a decellularized extracellular matrix from fish skin. The scaffold material may also include lipids from the lipid layer of the fish skin. Methods for making and using the scaffold material are also described.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: December 24, 2013
    Assignee: Kerecis EHF
    Inventors: Gudmundur Fertram Sigurjonsson, Dora Hlin Gisladottir, Gudmundur Gudmundsson
  • Patent number: 8591930
    Abstract: Described are tissue graft constructs that include submucosa and other extracellular matrix materials that incorporate a number of exogenous proteins. Further described are methods for making tissue graft constructs that include stripping endogenous heparin binding proteins from a porcine graft material and thereafter binding one or more human growth factors to the native heparin molecules that are retained within the graft material. Such graft materials may be used in methods for the treatment of wounds in patients.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: November 26, 2013
    Assignee: Cook Biotech Incorporated
    Inventors: Michael C. Hiles, Andrew Brightman, Abram D. Janis
  • Publication number: 20130302436
    Abstract: The present application is directed to the field of implants comprising soft tissue for use in implantation in humans. The soft tissue implants of the present application are preferably obtained from xenograft sources. The present application provides a chemical process that sterilizes, removes antigens from and/or strengthens xenograft implants. The present techniques yield soft tissue implants having superior structural, mechanical, and/or biochemical integrity. The present application is also directed to processes for treating xenograft implants comprising soft tissues such as dermis, and to implants produced by such processes.
    Type: Application
    Filed: March 14, 2013
    Publication date: November 14, 2013
    Inventors: Arnd WILHELMI, Silke Schreiner
  • Publication number: 20130287741
    Abstract: Flowable matrix compositions and methods of their use and manufacture are provided. Exemplary compositions may include a flowable, syringeable, putty-like form of acellular human dermal matrix. In some cases, compositions may include a moldable acellular collagen extracellular matrix. In use, the matrix compositions can be used to fill or treat skin voids, channel wounds, and other soft tissue deficiencies.
    Type: Application
    Filed: December 12, 2012
    Publication date: October 31, 2013
    Inventor: AlloSource
  • Patent number: 8568789
    Abstract: A dried product of an extract from inflammatory rabbit skin inoculated with vaccinia virus having an inhibitory activity for the production of a kallikrein-like substance is produced by admixing the extract with a saccharide, sugar alcohol or ascorbic acid before reaching dryness, and then drying the admixture to a solid form such as granules. The dried product may be employed to produce a solid preparation for oral administration, such as tablets, having an inhibitory activity for the production of a kallikrein-like substance.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: October 29, 2013
    Assignee: Nippon Zoki Pharmaceutical Co., Ltd.
    Inventors: Masaharu Kurohashi, Yoji Shibayama
  • Patent number: 8557581
    Abstract: The present invention is a process for preparing soft tissue such as tendons, ligaments, cartilage, fascia, dermis, human valves and human veins for implant in a human and removes cellular components and forms an decellular matrix having as major components collagens and elastins while sterilizing the tissue. The process comprises the following steps: (1) isolating from a suitable donor a desired soft tissue sample of the biological material; (2) processing and decellularizing the soft tissue including inspection for visual defects, trimming and soaking the tissue in a detergent depending on whether the tissue is fascia or dermis and rinsing same with sterile water; (3) sterilizing the soft tissue in a vacuum and soaking the tissue in an antibiotic composition or peracetic acid depending on whether the soft tissue is fascia or dermis and rinsing same; (4) processing the tissue by cutting the tissue to size and perforating the tissue; and (5) dipping the tissue in 70% ethanol and packaging the tissue.
    Type: Grant
    Filed: May 3, 2010
    Date of Patent: October 15, 2013
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Manh-Dan Ngo, Katherine Gomes Truncale, Jeffrey S. Cartmell, Carina Syring, Rudiger Von Versen
  • Publication number: 20130251670
    Abstract: Described are methods of treating macular edema, as well as other complications of ocular inflammation, through the administration of various stem cell populations and conditioned media thereof. In one embodiment a patient suffering from macular edema is administered an intramuscular dose of media conditioned by placental mesenchymal stem cells at a sufficient concentration and frequency to elicit a reduction in ocular inflammation. Other embodiments of the invention teach intra-ocular, intravenous, sublingual, and oral means of delivery conditioned media from various stem cell populations that has been optimized for anti-inflammatory, regenerative, and immune modulatory properties.
    Type: Application
    Filed: September 13, 2012
    Publication date: September 26, 2013
    Applicant: Aidan Products, Inc
    Inventors: Neil H. Riordan, Jorge Paz Rodriguez
  • Patent number: 8541032
    Abstract: Disclosed are tissue graft compositions made of materials having different densities, methods of making, and methods of treatment for restoring tissues in a patient.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: September 24, 2013
    Assignee: ACell, Inc.
    Inventor: Miles Grody
  • Patent number: 8535719
    Abstract: Provided herein is a biohybrid elastomeric scaffold comprising a synthetic polymeric component and a biological polymeric component. The scaffold can be fabricated to have many different forms, non-limiting examples of which include a non-woven fibrous mesh or in a porous composite. Methods of use of the biohybrid elastomeric scaffolds in wound healing and tissue regeneration are also provided.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: September 17, 2013
    Assignee: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Stephen F. Badylak, Donald O. Freytes, Thomas W. Gilbert, Jianjun Guan, John Stankus, William R. Wagner
  • Publication number: 20130236453
    Abstract: Methods and compositions for treating or preventing acute graft-versus-host disease (aGVHD) in a subject using miR-155 specific inhibitors are described.
    Type: Application
    Filed: March 12, 2013
    Publication date: September 12, 2013
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, Ramiro Garzon
  • Patent number: 8518396
    Abstract: The present invention is directed to compositions and methods of transplanting tissue, for example, in breast augmentation procedures. The compositions include adipose tissue and compounds that reduce tissue volume loss and increase survival rate of the adipose tissue when the composition is introduced into breast tissue.
    Type: Grant
    Filed: June 25, 2012
    Date of Patent: August 27, 2013
    Assignee: Allergan, Inc.
    Inventors: Dennis E. Van Epps, Guang-Liang Jiang, Wha Bin Im
  • Publication number: 20130202563
    Abstract: Provided herein are methods of making a cell growth scaffold from adipose tissue, cell growth scaffolds having low lipid content and methods of using the cell growth scaffold.
    Type: Application
    Filed: December 20, 2010
    Publication date: August 8, 2013
    Applicant: UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Stephen F. Badylak, Bryan N. Brown, John M. Freund, J. Peter Rubin
  • Publication number: 20130164383
    Abstract: The synthesis of collagen and proteoglycan in chondrocytes, such as intervertebral disc cells, articular chondrocytes and meniscal cells is promoted by administration of an extract from inflamed tissue inoculated with vaccinia virus.
    Type: Application
    Filed: October 11, 2011
    Publication date: June 27, 2013
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NIPPON ZOKI PHARMACEUTICAL CO., LTD.
    Inventors: Koichi Masuda, Mitsuru Naiki
  • Patent number: 8460714
    Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.
    Type: Grant
    Filed: April 3, 2012
    Date of Patent: June 11, 2013
    Assignee: TissueTech, Inc.
    Inventors: Scheffer Tseng, Hua He, Wei Li
  • Publication number: 20130142844
    Abstract: A method is provided for preparing a tissue implant for implantation. The method includes harvesting a tissue material from a human or an animal donor, treating the tissue material in a nuclease-containing solution, and thereafter treating the tissue material with an alkaline alcohol solution. The nuclease-containing solution includes an antimicrobial. The alkaline alcohol solution comprises sodium hydroxide and ethanol.
    Type: Application
    Filed: January 30, 2013
    Publication date: June 6, 2013
    Applicant: CRYOLIFE, INC.
    Inventor: CRYOLIFE, INC.