Embryonic Structure (e.g., Embryo Or Fetus, Etc.) Patents (Class 424/582)
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Patent number: 11491096Abstract: The inventive subject is directed towards ready-to-use topical cosmetic formulations that include at least one defensin present in sub-antimicrobially effective concentrations. Surprisingly, even at such low concentrations, defensins recruit LGR6+ stem cells from hair follicles to the interfollicular space. Including defensins in the inventive topical cosmetic formulations may reduce one or more of wrinkle depth, wrinkle length, wrinkle width, pore size, irregularity in texture of a skin surface, oiliness, brown spots, and red spots in non-injured skin, thus reducing apparent age.Type: GrantFiled: December 19, 2016Date of Patent: November 8, 2022Assignee: MEDICELL TECHNOLOGIES, LLCInventors: Nikolay Turovets, William B. Adams
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Patent number: 11382859Abstract: A cosmetic composition for the repair and remodeling of the human skin is provided. The cosmetic composition includes a therapeutically effective amount of human birth tissue material and a suitable carrier composition. Methods of treating human skin with the cosmetic composition, methods of reducing the appearance of a skin condition arising from aging and a corresponding kit are also provided.Type: GrantFiled: February 11, 2020Date of Patent: July 12, 2022Assignee: Brahm Holdings, LLCInventor: Timothy R. Brahm
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Patent number: 11116800Abstract: The invention relates generally to the fields of biology and life sciences. More particularly, the invention relates to compositions and methods for modulating cellular physiology and pathological processing using a combination of compounds that can be found in morselized amniotic membrane tissue and morselized umbilical cord tissue preparations.Type: GrantFiled: October 6, 2017Date of Patent: September 14, 2021Assignee: TISSUETECH, INC.Inventors: Scheffer Tseng, Lorraine Chua
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Patent number: 11033587Abstract: The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. In some embodiments, the invention relates to compositions of cells, eggs, cell extracts, egg extracts, and extract components such as purified nucleic acids, polypeptides, lipids, carbohydrates or other natural products.Type: GrantFiled: June 23, 2015Date of Patent: June 15, 2021Assignee: REGENICS ASInventors: Runhild Gammelsaeter, Jan Remmereit
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Patent number: 10905800Abstract: An ocular covering fabricated from at least one amniotic membrane, at least one chorionic membrane, or at least one amniotic membrane and at least one chorionic membrane obtained from human birth tissue is provided. Methods of preparing the one or more membranes to form an ocular covering are provided. Methods of treating a disease, condition, or surgical site of the eye and surrounding tissue are also provided.Type: GrantFiled: January 29, 2014Date of Patent: February 2, 2021Assignee: BioDlogics, LLCInventor: Timothy R. Brahm
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Patent number: 10821137Abstract: A composition for use in wound healing and therefor is disclosed. The multiple components of fish fertilized roe are extracted. By virtue of its ability as an anti-oxidant to eliminate free radicals, inhibition of tyrosinase activity and facilitate the mass secretion of collagen from skin fibroblasts in order to promote skin whitening, anti-aging and wound healing. Accordingly, skin all-round repair is achieved, which is used as a cosmetic raw material and a wound dressing.Type: GrantFiled: June 7, 2019Date of Patent: November 3, 2020Assignee: Tekho Marine Biotech Co., Ltd.Inventors: Tai-Lai Wang, Chih-Mou Wu
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Patent number: 10765705Abstract: Visco-supplement compositions derived from a transcellular fluid, such as human amniotic fluid, human aqueous humor fluid, or human vitreous fluid are described. Also described are methods for treating inflammatory conditions of the musculoskeletal system, such as joint inflammation, and methods of lubricating a joint using the described visco-supplement compositions.Type: GrantFiled: November 24, 2015Date of Patent: September 8, 2020Assignee: Prime Merger Sub, LLCInventor: Robin R. Young
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Patent number: 10555897Abstract: A cosmetic composition for the repair and remodeling of the human skin is provided. The cosmetic composition includes a therapeutically effective amount of human birth tissue material and a suitable carrier composition. Methods of treating human skin with the cosmetic composition, methods of reducing the appearance of a skin condition arising from aging and a corresponding kit are also provided.Type: GrantFiled: November 19, 2015Date of Patent: February 11, 2020Assignee: Brahm Holdings LLCInventor: Timothy R. Brahm
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Patent number: 10517994Abstract: Disclosed are tissue graft compositions made of materials having different densities, methods of making, and methods of treatment for restoring tissues in a patient.Type: GrantFiled: February 3, 2017Date of Patent: December 31, 2019Assignee: ACell, Inc.Inventors: Rodney W. Bosley, Jr., Clay Fette
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Patent number: 10071122Abstract: Disclosed herein are compositions including an extract of mammalian omentum wherein the extract is a liquid portion of the mammalian omentum, such as an oil, extracted when the omentum is heated to a temperature of between 210 and 240 degrees Fahrenheit. Also disclosed are methods of making a composition including an extract of mammalian omentum wherein the method includes heating mammalian omentum to a temperature of between 212 degrees Fahrenheit and 225 degrees Fahrenheit, such as 215 degrees Fahrenheit and 220 degrees Fahrenheit. Methods of use of the disclosed extracts and compositions are provided including methods of inducing or enhancing angiogenesis, methods of improving skin quality and methods of promoting hair growth and/or inhibiting hair loss.Type: GrantFiled: March 25, 2011Date of Patent: September 11, 2018Assignee: COOPERLABS LIMITEDInventors: James A. Greene, Jerad Busch, George Wrape, Jr., Jonathan D. Klein
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Patent number: 9682044Abstract: Disclosed herein, are methods of preparing fetal support tissue powders. Further disclosed herein, are methods of using the fetal support tissue powder product.Type: GrantFiled: June 8, 2012Date of Patent: June 20, 2017Assignee: TISSUETECH, INC.Inventors: Scheffer Tseng, Ek Kia Tan, Lorraine Chua
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Patent number: 9662355Abstract: Described herein are compositions and methods of treating a cardiac condition using modified placental tissue or an extract of a placental tissue, capable of recruiting stem cells or promoting healing in vivo and in vitro.Type: GrantFiled: January 17, 2014Date of Patent: May 30, 2017Assignee: MiMedx Group, Inc.Inventors: Thomas J. Koob, Frank H. Burrows, III
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Patent number: 9592193Abstract: A canine sebum substitute utilizes plant derived raw components that contain essential fatty acids, triglycerides and sterols present in canine sebum applied directly to the coat or added to pet products such as shampoos, conditioners, shine sprays, and detanglers to re-fat the hair and skin of dogs and improve shine and condition.Type: GrantFiled: May 15, 2014Date of Patent: March 14, 2017Assignee: Pet Research Labs, LLCInventor: David Paul Jarvis
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Patent number: 9427450Abstract: Disclosed are methods, compositions of matter, and protocols useful for the induction of a therapeutic immune modulatory response through administration of exosomes derived from a stem cell source. In one embodiment, said stem cell source is endometrial regenerative cells. Specifically, in one embodiment stem cell derived exosomes are used as a method of treating an autoimmune condition such as rheumatoid arthritis, multiple sclerosis, or systemic lupus erythromatosis.Type: GrantFiled: January 31, 2013Date of Patent: August 30, 2016Assignee: XON Cells, Inc.Inventors: Thomas Ichim, Vladimir Bogin
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Publication number: 20150140114Abstract: A skin treatment method, including: performing a skin treatment procedure on the skin of a patient, wherein the skin treatment procedure includes one of a chemical peel procedure, a dermabrasion procedure, a micro-needling procedure, and a laser procedure; and subsequently, applying a preparation including one or more of amniotic fluid and amniotic membrane material to the treated skin of the patient to promote healing and collagen rejuvenation, wherein the preparation including the one or more of amniotic fluid and amniotic membrane material is prepared from one or more of amniotic fluid, a concentrated amniotic membrane solution, and an amniotic membrane powder. The preparation comprising the one or more of amniotic fluid and amniotic membrane material also includes sterile water or saline. The treated skin of the patent preferably includes one or more of the skin of the face and the skin of the neck.Type: ApplicationFiled: November 18, 2014Publication date: May 21, 2015Inventor: John R. SASKO
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Publication number: 20150110892Abstract: The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. In preferred embodiments, the methods and agents comprise active extracts produced from fish eggs. The invention further provides processes for making active fish egg extracts.Type: ApplicationFiled: December 22, 2014Publication date: April 23, 2015Inventors: Runhild Gammelsaeter, Jan Remmereit
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Publication number: 20150079061Abstract: The invention provides a method of harvesting, processing and storing a plurality of proteins from a mammalian feto-placental unit. The method includes dissecting a mammalian uterus to harvest at least one component of the mammalian feto-placental unit; blast freezing the component; and storing the blast frozen component; wherein the blast frozen component includes the proteins. In one embodiment, the method includes lyophilizing the blast frozen component to remove at least some water from the blast frozen component thereby creating a freeze-dried form; and storing the lyophilized component; wherein the lyophilized component includes the proteins. The invention also provides a composition including proteins from at least one lyophilized, blast frozen component of a harvested mammalian feto-placental unit reconstituted with a fluid.Type: ApplicationFiled: July 14, 2014Publication date: March 19, 2015Inventors: Patrick J. Casey, Murray Hoare
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Publication number: 20150079062Abstract: The invention provides a method of harvesting, processing and storing a plurality of proteins from a mammalian feto-placental unit. The method includes dissecting a mammalian uterus to harvest at least one component of the mammalian feto-placental unit; blast freezing the component; and storing the blast frozen component; wherein the blast frozen component includes the proteins. In one embodiment, the method includes lyophilizing the blast frozen component to remove at least some water from the blast frozen component thereby creating a freeze-dried form; and storing the lyophilized component; wherein the lyophilized component includes the proteins. The invention also provides a composition including proteins from at least one lyophilized, blast frozen component of a harvested mammalian feto-placental unit reconstituted with a fluid.Type: ApplicationFiled: November 24, 2014Publication date: March 19, 2015Inventors: Patrick J. Casey, Murray Hoare
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Patent number: 8951572Abstract: A method of treating a renal, hepatic or enzyme-deficiency disorder in a subject in need thereof is disclosed. The method is effected by transplanting into the subject tissue derived from a human or porcine, kidney or liver, the kidney or liver being at a selected gestational stage.Type: GrantFiled: May 11, 2010Date of Patent: February 10, 2015Assignee: Yeda Research and Development Co. Ltd.Inventors: Yair Reisner, Benjamin Dekel, Smadar Eventov-Friedman, Helena Katchman, Elias Shezen, Anna Aronovich, Dalit Tchorsh
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Publication number: 20140356451Abstract: Provided herein are biocompatible polymer conjugates comprising a biologically compatible polymer covalently bound to a biologically compatible chelator moiety, which in turn are optionally bound, reversibly, to pharmacologically active metal ions. The biologically compatible polymer may comprise of modified placental tissue grafts composed of at least one membrane, capable of recruiting stem cells in vivo and in vitro.Type: ApplicationFiled: May 28, 2013Publication date: December 4, 2014Applicant: MiMedx Group, Inc,Inventor: Thomas J. Koob
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Publication number: 20140348940Abstract: The present invention provides compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane of the placenta. In certain embodiments, the composition comprises amniotic membrane powder or solubilized amniotic membrane (SAM). In some aspects, the composition is cell-free and rich in cytokines, extracellular matrix proteins, and other components that improve tissue regeneration. In one aspect, the composition is a hydrogel scaffold that comprises amniotic membrane. The present invention reduces contraction and improves blood vessel development in regenerating tissue.Type: ApplicationFiled: August 1, 2014Publication date: November 27, 2014Inventors: Sean V. Murphy, Aleksander Skardal, Anthony Atala
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Publication number: 20140341860Abstract: The invention is directed to methods for treating cartilage disorders, diseases and injuries including, but not limited to, degenerative disc disease. The invention is also directed to methods for preventing cartilage disorders and diseases including, but not limited to, degenerative disc disease. The field of the invention is further directed to reducing inflammation associated with cartilage disorders, diseases and injuries including, but not limited to, degenerative disc disease.Type: ApplicationFiled: May 13, 2014Publication date: November 20, 2014Applicant: STEMNION, INC.Inventors: Donna M. Olejniczak, David L. Steed, Randall G. Rupp, George L. Sing
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Publication number: 20140342015Abstract: The present invention provides compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane of the placenta. In certain embodiments, the composition comprises amniotic membrane powder or solubilized amniotic membrane (SAM). In some aspects, the composition is cell-free and rich in cytokines, extracellular matrix proteins, and other components that improve tissue regeneration. In one aspect, the composition is a hydrogel scaffold that comprises amniotic membrane. The present invention reduces contraction and improves blood vessel development in regenerating tissue.Type: ApplicationFiled: August 1, 2014Publication date: November 20, 2014Inventors: Sean V. Murphy, Aleksander Skardal, Anthony Atala
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Patent number: 8884096Abstract: The current invention is related to a method for the production of a human monoclonal antibody from a immunodeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently contacting said reconstituted animal with a antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.Type: GrantFiled: March 13, 2013Date of Patent: November 11, 2014Assignees: Bernd Mueller-BeckmannInventors: Alexander Lifke, Valeria Lifke, Bernd Mueller-Beckmann, Tobias Schnitzer
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Publication number: 20140302162Abstract: Described herein are composition composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.Type: ApplicationFiled: May 23, 2014Publication date: October 9, 2014Applicant: MiMedx Group, Inc.Inventors: Brenda S. Morse, Somaly Sith, Randall Spencer, Steven Ray, John Daniel, Robert Tofe
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Publication number: 20140271910Abstract: The invention is directed to methods for treating urushiol-induced contact dermatitis. Specifically, the invention is directed to treating and reducing inflammation associated with poison ivy, poison sumac and poison oak by administering to a subject suffering from such conditions novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions).Type: ApplicationFiled: March 10, 2014Publication date: September 18, 2014Applicant: Stemnion, Inc.Inventors: Larry R. Brown, Linda O. Palladino
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Publication number: 20140255508Abstract: Described herein are composition composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.Type: ApplicationFiled: May 23, 2014Publication date: September 11, 2014Applicant: MiMedx Group, Inc.Inventors: Brenda S. Morse, Somaly Sith, Randall Spencer, Steven Ray, John Daniel, Robert Tofe
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Patent number: 8808753Abstract: The invention is directed to methods for treating pustular conditions of the skin, for example, acne. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), cell lysates derived therefrom, and cell products derived therefrom, each alone or in combination.Type: GrantFiled: March 6, 2013Date of Patent: August 19, 2014Assignee: Stemnion, Inc.Inventors: Linda O Palladino, Vivienne S Marshall, Charlotte A Emig
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Publication number: 20140186461Abstract: Described herein are human amniotic membrane tissue grafts derived from the placenta. The grafts are composed of three layers as seen in the amniotic membrane in utero. These grafts are processed using physiologic solutions, lyophilized and terminal sterilized (via gamma irradiation in a frozen state) that thereby preserves the graft in such a manner as to retain the naturally occurring biological properties of the amniotic membrane and offer a sterile graft for transplantation. By dehydration via lyophilization and terminal sterilization, the graft has the advantage of storage at ambient temperatures for prolonged periods of time prior to transplantation.Type: ApplicationFiled: September 10, 2012Publication date: July 3, 2014Applicant: ALPHA TISSUE, INC.Inventor: Terry W. Broussard
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Patent number: 8759288Abstract: Means for improving the success rate of pregnancy on the basis of blastocyst transfer is disclosed. The means comprises an agent for promoting pregnancy in blastocyst transfer comprising the supernatant of the culture which is obtained by culturing a human embryo in a medium until the embryo develops into a blastocyst. Also disclosed are a method for production of the agent, as well as a method for promoting pregnancy comprising; culturing a human embryo in a medium until the human embryo develops into a blastocyst, injecting a composition comprising the supernatant of the culture into the uterine cavity of a patient who is to undergo blastocyst transfer, and then transferring the blastocyst to the recipient.Type: GrantFiled: September 25, 2012Date of Patent: June 24, 2014Assignee: JCR Pharmaceuticals Co., Ltd.Inventors: Masahide Shiotani, Sakae Goto
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Patent number: 8747294Abstract: The present invention relates, e.g., to a method for predicting the embryonic progression of a preimplantation embryo, comprising measuring in the insemination medium (IM) in which an oocyte was fertilized and subsequently incubated in vitro, thereby generating a pre-implantation embryo, at 18-24 hrs post fertilization, the levels of nitric oxide metabolites (NOx) in the insemination medium (IM), wherein a level of NOx of at least about 1.3 ?M indicates that the preimplantation embryo is likely to progress to the blastocyst stage by culture day (CD) 5.Type: GrantFiled: October 31, 2008Date of Patent: June 10, 2014Assignee: The Johns Hopkins UniversityInventors: Christopher William Lipari, Annabelle Rodriguez
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Publication number: 20140147511Abstract: Disclosed herein, are methods of preparing fetal support tissue powders. Further disclosed herein, are methods of using the fetal support tissue powder product.Type: ApplicationFiled: June 8, 2012Publication date: May 29, 2014Applicant: TISSUE TECH, INC.Inventors: Scheffer Tseng, Ek Kia Tan, Lorraine Chua
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Publication number: 20140112998Abstract: Disclosed herein, in certain instances, are methods of inhibiting osteoclast differentiation, bone resorption, bone formation, and bone remodeling in an individual in need thereof, comprising administering to the individual a composition comprising substantially fetal support tissue product including amniotic membrane and umbilical cord or an extract thereof, or a composition comprising substantially isolated HC-HA complex.Type: ApplicationFiled: April 27, 2012Publication date: April 24, 2014Applicant: TISSUETECH, INC.Inventors: Scheffer Tseng, Ek Kia Tan, Hua He
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Publication number: 20140037752Abstract: The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. In preferred embodiments, the methods and agents comprise active extracts produced from fish eggs. The invention further provides processes for making active fish egg extracts.Type: ApplicationFiled: October 8, 2013Publication date: February 6, 2014Applicant: REGENICS ASInventors: Runhild Gammelsaeter, Jan Remmereit
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Publication number: 20130344162Abstract: Described herein are composition composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.Type: ApplicationFiled: March 6, 2013Publication date: December 26, 2013Inventors: Brenda S. MORSE, Somaly SITH, Randall SPENCER, Steven RAY, John DANIEL, Robert Tofe
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Publication number: 20130287741Abstract: Flowable matrix compositions and methods of their use and manufacture are provided. Exemplary compositions may include a flowable, syringeable, putty-like form of acellular human dermal matrix. In some cases, compositions may include a moldable acellular collagen extracellular matrix. In use, the matrix compositions can be used to fill or treat skin voids, channel wounds, and other soft tissue deficiencies.Type: ApplicationFiled: December 12, 2012Publication date: October 31, 2013Inventor: AlloSource
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Publication number: 20130251670Abstract: Described are methods of treating macular edema, as well as other complications of ocular inflammation, through the administration of various stem cell populations and conditioned media thereof. In one embodiment a patient suffering from macular edema is administered an intramuscular dose of media conditioned by placental mesenchymal stem cells at a sufficient concentration and frequency to elicit a reduction in ocular inflammation. Other embodiments of the invention teach intra-ocular, intravenous, sublingual, and oral means of delivery conditioned media from various stem cell populations that has been optimized for anti-inflammatory, regenerative, and immune modulatory properties.Type: ApplicationFiled: September 13, 2012Publication date: September 26, 2013Applicant: Aidan Products, IncInventors: Neil H. Riordan, Jorge Paz Rodriguez
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Publication number: 20130251675Abstract: The invention is directed to novel methods for modulating inflammatory and/or immune responses. Such methods utilize compositions comprising extraembryonic cells (herein referred to as EE cells) including but not limited to extraembryonic HLA-G positive cells (herein referred to as EHP cells) and amnion-derived multipotent progenitor cells (herein referred to as AMP cells); compositions comprising expanded EE cell populations, and/or cell lysates and/or conditioned media derived therefrom, alone or in combination with each other and/or in combination with various extracellular matrices and/or devices and/or other suitable active agents.Type: ApplicationFiled: February 23, 2013Publication date: September 26, 2013Applicant: STEMNION, INC.Inventors: Richard A Banas, Catherine J. Trumpower
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Publication number: 20130236506Abstract: A construct for use in an OB/GYN surgery is described. The construct contains an allograft having at least one layer of human amnion and chorion tissues, and has a size and shape appropriate for covering an incision or a surgical site resulting from the surgery. Methods of preparing the construct and using it in an OB/GYN surgery are also described. The products and methods improve the performance of the OB/GYN surgery, e.g., by reducing adhesions, scar formation while also reducing inflammation and risk of post-operative infection.Type: ApplicationFiled: March 8, 2013Publication date: September 12, 2013Applicant: AFCELL MEDICALInventor: Robin R. YOUNG
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Publication number: 20130183387Abstract: The invention is directed to methods for treating pustular conditions of the skin, for example, acne. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), cell lysates derived therefrom, and cell products derived therefrom, each alone or in combination.Type: ApplicationFiled: March 6, 2013Publication date: July 18, 2013Applicant: STEMNION, INC.Inventor: STEMNION, INC.
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Publication number: 20130183285Abstract: The invention is directed to methods for accelerating the healing of connective tissue injuries and disorders. In particular, the invention is directed to accelerating the healing of injuries and disorders of tendons and ligaments. Such methods utilize novel compositions including, but not limited to, extraembryonic cytokine-secreting cells (herein referred to as ECS cells), including, but not limited to, Amnion-derived Multipotent Progenitor cells (herein referred to as AMP cells) and conditioned media derived therefrom (herein referred to as Amnion-derived Cellular Cytokine Solution or ACCS), including pooled ACCS, and Physiologic Cytokine Solution (PCS).Type: ApplicationFiled: March 5, 2013Publication date: July 18, 2013Applicant: Stemnion, Inc.Inventor: Stemnion, Inc.
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Patent number: 8460713Abstract: The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. In some embodiments, the invention relates to compositions of cells, eggs, cell extracts, egg extracts, and extract components such as purified nucleic acids, polypeptides, lipids, carbohydrates or other natural products.Type: GrantFiled: October 6, 2011Date of Patent: June 11, 2013Assignee: Regenics ASInventors: Runhild Gammelsaeter, Jan Remmereit
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Patent number: 8435788Abstract: A method of manufacturing a tissue matrix for implantation into a patient is disclosed. The method sets forth collecting embryonic stem cells from a placenta which has been treated to remove residual cord blood and seeding the collected stem cells onto or into a tissue matrix. The seeded tissue matrix is then implanted on or into a patient. The seeded tissue matrix made by the method of the present invention is also disclosed.Type: GrantFiled: June 24, 2010Date of Patent: May 7, 2013Assignee: Anthrogenesis CorporationInventor: Robert J. Hariri
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Publication number: 20130089514Abstract: Compositions including formulations comprising secreted products obtained from the culture medium of stem cells, such as umbilical cord blood stem cells, or embryonic germ cell derivatives, or embryonic stem cells, are provided for enhancement of wound healing. Further compositions contain components identified in such culture medium to enhance wound healing. Methods for using the compositions and formulations for enhancing wound healing are also provided. Wounds to both soft and bony tissues are encompassed, and include wounds created by surgical procedures.Type: ApplicationFiled: November 29, 2012Publication date: April 11, 2013Inventors: Michael Cohen, Jacob Cohen
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Patent number: 8414929Abstract: The dried amniotic membrane is produced by drying a fresh amniotic membrane, which envelopes an embryo of an animal including human, and can be used as a substitute membrane for a membrane tissue in a living body; the dried amniotic membrane is dehydrated and dried so that the dried amniotic membrane can be stored in a dry air in a sterile state; when hydrated again by immersing in water or a buffer solution, the amniotic membrane still has an epithelial cell, a basement membrane and a connective tissue which constitute the fresh amniotic membrane. The dried amniotic membrane is useful as a medical substitute membrane for a membrane tissue in a living body such as a dura mater, a meninx, a pericardium, a pleura and a peritoneum.Type: GrantFiled: February 21, 2008Date of Patent: April 9, 2013Assignee: National University Corporation University of ToyamaInventors: Toshio Nikaido, Motonori Okabe, Toshiko Yoshida, Shunro Endo, Nakamasa Hayashi, Shigeru Saito
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Patent number: 8372439Abstract: Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.Type: GrantFiled: August 7, 2012Date of Patent: February 12, 2013Assignee: Mimedx Group, Inc.Inventors: John Daniel, Robert Tofe, Randall Spencer, John Russo
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Patent number: 8372437Abstract: A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. The grafts are comprised of single layers of amnion or chorion, multiple layers of amnion or chorion, or multiple layers of a combination of amnion and chorion.Type: GrantFiled: August 17, 2007Date of Patent: February 12, 2013Assignee: Mimedx Group, Inc.Inventor: John Daniel
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Patent number: 8357403Abstract: Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.Type: GrantFiled: September 8, 2008Date of Patent: January 22, 2013Assignee: Mimedx Group, Inc.Inventors: John Daniel, Robert Tofe, Randall Spencer, John Russo
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Publication number: 20120315259Abstract: A method and composition for treating dermatological conditions and improving skin condition and helping hair to grow or thicken involves removing extracts including beneficial secretions from mesenchymal stem cells or other cells with regenerative properties to use itself or components thereof alone or with other skin or hair care reagents as a topical ointment or formula to apply to the skin or hair topically for therapeutic and cosmetic purposes.Type: ApplicationFiled: February 1, 2011Publication date: December 13, 2012Inventor: Hyman Friedlander
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Publication number: 20120315246Abstract: The invention is directed to novel compositions and methods for modulating inflammatory and/or immune responses. Such novel compositions are derived from extraembryonic cells (herein referred to as EE cells) including but not limited to extraembryonic HLA-G positive cells (herein referred to as extraembryonic HLA-G positive or “EHP” cells) and Amnion-derived Multipotent Progenitor cells (herein referred to as AMP cells), alone or in combination with each other and/or in combination with various matrices and/or devices and/or other suitable active agents. The novel methods of modulating inflammatory and/or immune responses utilize such novel compositions.Type: ApplicationFiled: June 1, 2012Publication date: December 13, 2012Inventors: Randall G. Rupp, Richard A. Banas