Placenta Or Umbilical Cord Patents (Class 424/583)
  • Patent number: 11207355
    Abstract: An enriched amnion derived tissue graft has a stromal matrix layer and an epithelium layer. A stromal matrix layer may contain a basement membrane layer, a compact layer, a fibroblast layer, and an intermediate layer. An amnion derived tissue graft may have a plurality of tissue layers and the layers may be configured with the epithelium layers toward the inside and the stromal matrix layers toward the outside surface. An enriched portion may be coated onto or be configured within a tissue layer and have an increased concentration of cells, of proteins, growth factors, seed cells, pharmaceuticals or any combination thereof. A carrier fluid such as amniotic fluid may be used to produce an enrichment composition for coating the tissue graft. The cells within the enriched portion may be stem cells from the amnion, or cells from other tissue and may be seed cells selected based on the treatment location.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: December 28, 2021
    Assignee: AMNIO TECHNOLOGY LLC
    Inventors: Christian Beaudry, Merrill B. Stromer, Grant D. Senner
  • Patent number: 10844378
    Abstract: Isolation or in vitro assembly of the Cas9-crRNA complex of the Streptococcus thermophilus CRISPR3/Cas system and use for cleavage of DNA bearing a nucleotide sequence complementary to the crRNA and a proto-spacer adjacent motif. Methods for site-specific modification of a target DNA molecule using an RNA-guided DNA endonuclease comprising at least one RNA sequence and at least one of an RuvC active site motif and an HNH active site motif; for conversion of Cas9 polypeptide into a nickase cleaving one strand of double-stranded DNA by inactivating one of the active sites (RuvC or HNH) in the polypeptide by at least one point mutation; for assembly of active polypeptide-polyribonucleotides complex in vivo or in vitro; and for re-programming a Cas9-crRNA complex specificity in vitro or using a cassette containing a single repeat-spacer-repeat unit.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: November 24, 2020
    Assignee: Vilnius University
    Inventors: Virginijus {hacek over (S)}ik{hacek over (s)}nys, Giedrius Gasiūnas, Tautvydas Karvelis
  • Patent number: 10646519
    Abstract: This invention provides a fluid therapeutic placental product comprising placental cells and a placental dispersion comprising placental factors. The placental cells and the placental dispersion are derived from placental tissue. A placental tissue can optionally be an amnion, chorion, or a trophoblast-depleted chorion. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: May 12, 2020
    Assignee: Osiris Therapeutics, Inc.
    Inventors: Samson Tom, Alla Danilkovitch, Dana Yoo, Timothy Jansen, Jin-Qiang Kuang, Jennifer Michelle Marconi
  • Patent number: 10500146
    Abstract: A skin whitening composition includes amorphigeni or a salt thereof as an effective ingredient. Amorphigeni suppresses the expression of tyrosinase and induces autophagy on melanosomes. As such, it was confirmed that amorphigeni not only suppresses melanin production but also exhibits the effect of removing melanin previously produced by ?-MSH (melanocyte-stimulating hormone). Accordingly, amorphigeni can be advantageously used as a functional material for skin whitening and skin lightening.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: December 10, 2019
    Assignee: INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY
    Inventors: Kwang Dong Kim, Ji Yun Yoo, Soojong Park, Sangseok Oh, Dae Wook Kim, Ki Hun Park, Kiwon Lee
  • Patent number: 10245349
    Abstract: A method of treating a soft tissue defect in or on the body of a patient is provided. A placental construct for treatment of a disease or condition is also provided. The placental construct includes a therapeutically effective amount of a birth tissue material.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: April 2, 2019
    Assignee: BioDlogics, LLC
    Inventor: Timothy R. Brahm
  • Patent number: 10029030
    Abstract: Described herein are molded dehydrated placental tissue compositions, and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the molded dehydrated placental tissue compositions are also described herein.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 24, 2018
    Assignee: MiMedx Group, Inc.
    Inventors: Thomas J. Koob, Guilhem Denoziere, Rebeccah J.C. Brown
  • Patent number: 9913466
    Abstract: A method for cryopreserving an umbilical cord tissue strip includes the steps of: (a) applying tension to a segment of an umbilical cord to expand spaces between umbilical cord vessels; (b) cutting the segment of the umbilical cord, at the spaces between the umbilical cord vessels in a longitudinal direction that parallels a length of the umbilical cord vessels, to obtain the umbilical cord tissue strip, wherein the umbilical cord tissue strip contains Wharton's jelly from a perivascular region, a intervascular region, and a subamnion region; (c) incubating the umbilical cord tissue strip with a cryogenic composition; and (d) cryopreserving the umbilical cord tissue strip containing the Wharton's jelly and the cryogenic composition.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: March 13, 2018
    Assignee: HealthBanks Biotech Co. Ltd.
    Inventors: Pei-Chi Tseng, Xiang-Rui Xu, Chi-Hsuan Huang, Wei-Yu Lo
  • Patent number: 9867855
    Abstract: The present invention is directed to the use of mitotically and/or lethally inactivated stem cells for the repair of damaged organs and/or tissues. Stem cells are mitotically and/or lethally inactivated and transplanted into damaged tissue. Any form of ex vivo inactivation of stem cells may be used such that the stem cells cannot undergo mitosis or cell division before in vivo application. Mitotically and/or lethally inactivated stem may be used to ameliorate numerous disease, injury, traumatic, ischemic, aging, and/or degenerative conditions in different types of organs and/or tissues.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: January 16, 2018
    Inventor: Richard Burt
  • Patent number: 9433646
    Abstract: Disclosed are methods of preparing and using placentally-derived stem cells and compositions useful for the treatment of cancer. Said stem cells and compositions function through inducing a “guided differentiation” program in cancer cells, thereby reducing malignancy. Further extension of the invention pertains to augmenting ability of administered cells to induce differentiation through the co-administration of known differentiation inducing agents. Within the context of this disclosure, methods for inducing host responses to cancer are also described.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: September 6, 2016
    Assignee: XON CELLS, INC.
    Inventor: Thomas E. Ichim
  • Patent number: 9272003
    Abstract: Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: March 1, 2016
    Assignee: MiMedx Group, Inc.
    Inventors: John Daniel, Randall Spencer, John Russo, Robert Tofe
  • Patent number: 9186382
    Abstract: Described herein are placental tissue grafts produced by chemical dehydration followed by freeze-drying the placental tissue to produce the tissue graft. The tissue grafts retain their biological properties preferably at the same level as the placental tissues before they are processed. The placental tissue grafts have numerous medical applications. Methods for making the tissue graft compositions are also described herein.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: November 17, 2015
    Assignee: MiMedx Group, Inc.
    Inventors: John Daniel, Randall Spencer, Steven Ray
  • Patent number: 9161955
    Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: October 20, 2015
    Assignee: TISSUETECH, INC.
    Inventors: Scheffer Tseng, Hua He, Wei Li
  • Patent number: 9161954
    Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: October 20, 2015
    Assignee: TISSUETECH, INC.
    Inventors: Scheffer Tseng, Hua He, Wei Li
  • Patent number: 9084767
    Abstract: Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: July 21, 2015
    Assignee: MiMedx Group, Inc.
    Inventors: John Daniel, Randall Spencer, John Russo, Robert Tofe
  • Publication number: 20150110850
    Abstract: A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. The grafts are comprised of single layers of amnion or chorion, multiple layers of amnion or chorion, or multiple layers of a combination of amnion and chorion.
    Type: Application
    Filed: December 29, 2014
    Publication date: April 23, 2015
    Inventor: John Daniel
  • Publication number: 20150086573
    Abstract: A placental construct for treatment of a disease or condition is provided. The placental construct includes a therapeutically effective amount of a birth tissue material.
    Type: Application
    Filed: December 2, 2014
    Publication date: March 26, 2015
    Inventor: Timothy R. Brahm
  • Publication number: 20150086634
    Abstract: Described herein are methods of using molded dehydrated placental compositions, and cosmetic compositions thereof. The compositions have numerous cosmetic applications.
    Type: Application
    Filed: September 8, 2014
    Publication date: March 26, 2015
    Inventors: Thomas J. Koob, Rebeccah J.C. Brown
  • Publication number: 20150079061
    Abstract: The invention provides a method of harvesting, processing and storing a plurality of proteins from a mammalian feto-placental unit. The method includes dissecting a mammalian uterus to harvest at least one component of the mammalian feto-placental unit; blast freezing the component; and storing the blast frozen component; wherein the blast frozen component includes the proteins. In one embodiment, the method includes lyophilizing the blast frozen component to remove at least some water from the blast frozen component thereby creating a freeze-dried form; and storing the lyophilized component; wherein the lyophilized component includes the proteins. The invention also provides a composition including proteins from at least one lyophilized, blast frozen component of a harvested mammalian feto-placental unit reconstituted with a fluid.
    Type: Application
    Filed: July 14, 2014
    Publication date: March 19, 2015
    Inventors: Patrick J. Casey, Murray Hoare
  • Publication number: 20150079062
    Abstract: The invention provides a method of harvesting, processing and storing a plurality of proteins from a mammalian feto-placental unit. The method includes dissecting a mammalian uterus to harvest at least one component of the mammalian feto-placental unit; blast freezing the component; and storing the blast frozen component; wherein the blast frozen component includes the proteins. In one embodiment, the method includes lyophilizing the blast frozen component to remove at least some water from the blast frozen component thereby creating a freeze-dried form; and storing the lyophilized component; wherein the lyophilized component includes the proteins. The invention also provides a composition including proteins from at least one lyophilized, blast frozen component of a harvested mammalian feto-placental unit reconstituted with a fluid.
    Type: Application
    Filed: November 24, 2014
    Publication date: March 19, 2015
    Inventors: Patrick J. Casey, Murray Hoare
  • Publication number: 20150079193
    Abstract: The present invention relates to compositions and methods of inducing angiogenesis and methods of treating a pathology that would benefit from angiogenesis by use of a composition comprising partially purified intact mitochondria and/or ruptured mitochondria derived therefrom.
    Type: Application
    Filed: May 16, 2013
    Publication date: March 19, 2015
    Inventors: Natalie Yivgi-Ohana, Uriel Halavee, Shmuel Bukshpan
  • Publication number: 20150064274
    Abstract: Provided herein are micronized placental compositions composed of micronized placental tissue component, such as amnion or chorion and/or filler bound to one or more chelating agents, which in turn are optionally bound, reversibly, to pharmacologically active metal ions. Further provided are methods of making and using the placental compositions. The compositions have numerous therapeutic applications.
    Type: Application
    Filed: August 28, 2014
    Publication date: March 5, 2015
    Inventor: Thomas J. Koob
  • Publication number: 20150017255
    Abstract: Described herein are compositions and methods of treating a cardiac condition using modified placental tissue or an extract of a placental tissue, capable of recruiting stem cells or promoting healing in vivo and in vitro.
    Type: Application
    Filed: January 17, 2014
    Publication date: January 15, 2015
    Inventors: Thomas J. Koob, Hubbard Frank Burrows, III
  • Patent number: 8932643
    Abstract: Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: January 13, 2015
    Assignee: MiMedx Group, Inc.
    Inventors: John Daniel, Robert Tofe, Randall Spencer, John Russo
  • Publication number: 20140370068
    Abstract: A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. The grafts are comprised of single layers of amnion or chorion, multiple layers of amnion or chorion, or multiple layers of a combination of amnion and chorion.
    Type: Application
    Filed: May 22, 2014
    Publication date: December 18, 2014
    Applicant: MiMedx Group, Inc.
    Inventor: John Daniel
  • Publication number: 20140335046
    Abstract: A method of inducing or promoting hair growth on the scalp of a subject, comprising the steps of (i) providing an ECM composition including at least one ECM material, (ii) administering inciting event means to a target skin location on the subject to induce an inciting event, and (iii) administering a therapeutically effective amount of said ECM composition to the target skin location. In some embodiments, the ECM composition includes at least one additional biologically active agent.
    Type: Application
    Filed: September 19, 2013
    Publication date: November 13, 2014
    Inventor: Robert G. Matheny
  • Publication number: 20140301986
    Abstract: Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
    Type: Application
    Filed: May 30, 2014
    Publication date: October 9, 2014
    Applicant: Osiris Therapeutics, Inc.
    Inventors: Samson Tom, Alla Danilkovitch, Dana Yoo, Timothy Jansen, Jin-Qiang Kuang, Jennifer Michelle Marconi
  • Publication number: 20140294777
    Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
    Type: Application
    Filed: February 5, 2014
    Publication date: October 2, 2014
    Applicant: OSIRIS THERAPEUTICS, INC.
    Inventors: Samson Tom, Alla Danilkovitch, Dana Yoo, Timothy Jansen, Jin-Qiang Kuang, Jennifer Michelle Marconi
  • Publication number: 20140294780
    Abstract: The present disclosure provides methods and compositions, including a placental extract, for inducing and/or modulating angiogenesis; methods of identifying modulators of angiogenesis, and assays for identifying modulators of angiogenesis. The present disclosure also provides methods of making a composition, including a placental extract that can induce and/or modulate angiogenesis.
    Type: Application
    Filed: April 2, 2014
    Publication date: October 2, 2014
    Inventor: Peter S. McFetridge
  • Publication number: 20140271728
    Abstract: Described herein are molded dehydrated placental tissue compositions, and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the molded dehydrated placental tissue compositions are also described herein.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Applicant: MiMedx Group, Inc.
    Inventor: MiMedx Group, Inc.
  • Publication number: 20140271776
    Abstract: Preparations derived from placental materials and methods of making and using same, the preparations including a first preparation composed of placental membranes digested in collagenase, a second preparation composed of multipotent cells derived from the collagenase digested placental membranes and that are grown in adherent culture beyond confluence and a third preparation composed of ground placental membranes re-suspended in a fluid containing hyaluronic acid. The preparations can be used for regenerating damaged or defective tissue including connective tissue, nerve tissue, muscle tissue, skin tissue, cartilage tissue and bone tissue. The preparations can also be used as dermal fillers in cosmetic and plastic surgery applications.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: NuTech Medical, Inc.
    Inventors: Jeremy B. Vines, Howard P. Walthall, JR.
  • Publication number: 20140255496
    Abstract: Described herein are compositions composed of micronized placental components, extracts of micronized placental components, and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions and the extracts thereof are also described herein.
    Type: Application
    Filed: May 22, 2014
    Publication date: September 11, 2014
    Inventors: John Daniel, Randall Spencer, Somaly Sith
  • Publication number: 20140242184
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Application
    Filed: May 5, 2014
    Publication date: August 28, 2014
    Inventor: Robert G Matheny
  • Patent number: 8815587
    Abstract: Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: August 26, 2014
    Assignee: DePuy Synthes Products, LLC
    Inventors: Ian R. Harris, Darin J. Messina, Anthony J. Kihm, Agnieszka Seyda, David C. Colter
  • Patent number: 8808753
    Abstract: The invention is directed to methods for treating pustular conditions of the skin, for example, acne. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), cell lysates derived therefrom, and cell products derived therefrom, each alone or in combination.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: August 19, 2014
    Assignee: Stemnion, Inc.
    Inventors: Linda O Palladino, Vivienne S Marshall, Charlotte A Emig
  • Patent number: 8790923
    Abstract: Viable progenitor cells are extracted from frozen umbilical cord tissue. In embodiments, the umbilical cord tissue is a blood vessel bearing perivascular Wharton's jelly, and the extracted progenitor cells are HUCPVCs.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: July 29, 2014
    Inventors: Jane E. Ennis, Rahul Sarugaser, John E. Davies
  • Publication number: 20140154226
    Abstract: Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.
    Type: Application
    Filed: January 10, 2014
    Publication date: June 5, 2014
    Applicant: DePuy Synthes Products, LLC
    Inventors: Darin J. Messina, Alexander M. Harmon, Ian R. Harris, Anthony J. Kihm, Sanjay Mistry, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
  • Publication number: 20140147511
    Abstract: Disclosed herein, are methods of preparing fetal support tissue powders. Further disclosed herein, are methods of using the fetal support tissue powder product.
    Type: Application
    Filed: June 8, 2012
    Publication date: May 29, 2014
    Applicant: TISSUE TECH, INC.
    Inventors: Scheffer Tseng, Ek Kia Tan, Lorraine Chua
  • Publication number: 20140127317
    Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
    Type: Application
    Filed: November 1, 2013
    Publication date: May 8, 2014
    Applicant: Osiris Therapeutics, Inc.
    Inventors: Timothy Jansen, Samson Tom, Alla Danilkovitch, Dana Yoo, Jaime Zerhusen
  • Patent number: 8709493
    Abstract: Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.
    Type: Grant
    Filed: February 12, 2013
    Date of Patent: April 29, 2014
    Assignee: Mimedx Group, Inc.
    Inventors: John Daniel, Robert Tofe, Randall Spencer, John Russo
  • Patent number: 8709494
    Abstract: A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. The grafts are comprised of single layers of amnion or chorion, multiple layers of amnion or chorion, or multiple layers of a combination of amnion and chorion.
    Type: Grant
    Filed: July 30, 2013
    Date of Patent: April 29, 2014
    Assignee: MiMedx Group, Inc.
    Inventor: John Daniel
  • Publication number: 20140112998
    Abstract: Disclosed herein, in certain instances, are methods of inhibiting osteoclast differentiation, bone resorption, bone formation, and bone remodeling in an individual in need thereof, comprising administering to the individual a composition comprising substantially fetal support tissue product including amniotic membrane and umbilical cord or an extract thereof, or a composition comprising substantially isolated HC-HA complex.
    Type: Application
    Filed: April 27, 2012
    Publication date: April 24, 2014
    Applicant: TISSUETECH, INC.
    Inventors: Scheffer Tseng, Ek Kia Tan, Hua He
  • Patent number: 8703207
    Abstract: Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: April 22, 2014
    Assignee: Mimedx Group, Inc.
    Inventors: John Daniel, Randall Spencer, Robert Tofe, John Russo
  • Patent number: 8703206
    Abstract: Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.
    Type: Grant
    Filed: January 15, 2013
    Date of Patent: April 22, 2014
    Assignee: MiMedx Group, Inc.
    Inventors: John Daniel, Robert Tofe, Randall Spencer, John F. Russo
  • Publication number: 20140088339
    Abstract: Methods for treating a cardiovascular disorder comprising concomitant administration of one or more extracellular matrix (ECM) based compositions directly to damaged or diseased cardiovascular tissue associated with the cardiovascular disorder, and provision of ventricular assistance. In a preferred embodiment, the ECM based compositions include an ECM material derived from a mammalian source.
    Type: Application
    Filed: March 1, 2013
    Publication date: March 27, 2014
    Applicant: Francis Law Group
    Inventor: Robert Matheny
  • Patent number: 8642092
    Abstract: Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.
    Type: Grant
    Filed: April 11, 2013
    Date of Patent: February 4, 2014
    Assignee: Mimedx Group, Inc.
    Inventors: John Daniel, Randall Spencer, John Russo, Robert Tofe
  • Patent number: 8623421
    Abstract: A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. The grafts are comprised of single layers of amnion or chorion, multiple layers of amnion or chorion, or multiple layers of a combination of amnion and chorion.
    Type: Grant
    Filed: July 26, 2013
    Date of Patent: January 7, 2014
    Assignee: MiMedx Group, Inc.
    Inventor: John Daniel
  • Patent number: 8617535
    Abstract: The present invention provides cytotherapeutic units comprising predetermined numbers of selected types of potent cells. Assurance of the nature and identities of such cells is achieved through assay and certification of said numbers and identities. Therapeutic modalities are provided. Libraries of cell preparations with assayed and preferably certified populations are preferred and the preparation of cell preparations tailored to specific patients or disease states are provided.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: December 31, 2013
    Assignee: Anthrogenesis Corporation
    Inventor: Robert J. Hariri
  • Publication number: 20130344163
    Abstract: Disclosed herein, in certain instances, are tissue grafts derived from UCAM. Further disclosed herein, in certain instances, are use for tissue grafts derived from UCAM.
    Type: Application
    Filed: March 13, 2013
    Publication date: December 26, 2013
    Inventors: Scheffer TSENG, Ek Kia TAN, Amy TSENG
  • Patent number: 8597687
    Abstract: A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. The grafts are comprised of single layers of amnion or chorion, multiple layers of amnion or chorion, or multiple layers of a combination of amnion and chorion.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: December 3, 2013
    Assignee: Mimedx Group, Inc.
    Inventor: John Daniel
  • Publication number: 20130309317
    Abstract: The present invention provides a food supplement, which comprises: a placental extract and an oil; which would promote the proliferation of CD34+ stem cells and increase the telomerase activity to achieve rejuvenation and anti-aging.
    Type: Application
    Filed: September 4, 2012
    Publication date: November 21, 2013
    Applicant: GWO XI STEM CELL APPLIED TECHNOLOGY CO. LTD.
    Inventors: HORNG-JYH HARN, SHINN-ZONG LIN, PO-CHENG LIN, HSIN-I WANG, PI-CHUN HUANG