Calcium Containing Patents (Class 424/602)
  • Patent number: 10149920
    Abstract: The disclosure relates to an implant material for filling bone defects, for bone regeneration, and for bone tissue engineering, to an implant comprising this material, to a method for producing such an implant, and to a method for producing a hybrid material. The implant material comprises a hybrid material comprising: a bioactive glass M based on SiO2 and CaO, optionally containing P2O5 and/or optionally doped with strontium, and a biodegradable polymer P soluble in a solvent and chosen from among bioresorbable polysaccharides. The implant material has applications in the medical field.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: December 11, 2018
    Assignees: UNIVERSITE CLERMONT AUVERGNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jonathan Claude Alexandre Lao, Joséphine Lacroix, Edouard Daniel Albert Jallot, Xavier Dieudonne
  • Patent number: 10052402
    Abstract: Compositions of, methods of making, and methods of using alkaline earth phosphate bone cements are disclosed.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: August 21, 2018
    Assignee: THE UNIVERSITY OF TOLEDO
    Inventors: Sarit B. Bhaduri, Huan Zhou, Anand K. Agarwal, Vijay K. Goel
  • Patent number: 9956169
    Abstract: A fast-dissolving dosage form (FDDF) for the delivery of a vaccine is prepared using a formulation containing a starch, optionally, along with at least one additional matrix forming agent, preferably, a combination of gelatin and mannitol, where an immune response is induced in a patient in need thereof.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: May 1, 2018
    Assignee: R.P. SCHERER TECHNOLOGIES, LLC
    Inventors: Wei Tian, Rosie McLaughlin
  • Patent number: 9861587
    Abstract: A method for prophylactic treatment of ketosis in a calving cow, the method including orally administering to the cow within a time period of about 12 hours after calving an effective dose of from 20 to 30 g of rumen protected methionine. If the cow falls into a risk category, the cow is administered the dose of rumen protected methionine once a day on the second, third, fourth, and fifth days after calving. Also, a composition including a gelatin capsule and rumen-protected methionine contained within the gelatin capsule that may be administered to a calving cow for the prophylactic treatment of ketosis. The composition may further contain within the gelatin capsule one or more other compounds known to have efficacy on fat or glucose metabolism, such as glucose, propylene glycol, niacin, choline, chromium, calcium propionate, and glucocorticoids.
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: January 9, 2018
    Assignee: RP FEED COMPONENTS, LLC
    Inventors: James M. Rohrer, Patrick D. French, Keith F. Moritz
  • Patent number: 9801907
    Abstract: Calcium-containing compounds have been at least partly film-coated and/or granulated with a water-soluble substance and a water-soluble polymeric substance and use of such coated compounds in pharmaceutical compositions. The at least partly film-coated and/or granulated calcium-containing compounds have proved suitable for the preparation of tablets having a very high load of elemental calcium and a conveniently small size. A drug load of about 96% or more is obtained in tablets of the invention that have sufficient mechanical and organoleptic properties.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: October 31, 2017
    Assignee: Takeda AS
    Inventor: Jan Yngvar Piene
  • Patent number: 9776869
    Abstract: The disclosure features compositions that include a material featuring three calcium phosphate phases that form one or more integral units of a solid, where a first one of the three phases includes one or more regions formed of hydroxyapatite, a second one of the three phases includes one or more regions formed of ?-tricalcium phosphate, a third one of the three phases includes one or more regions formed of amorphous calcium phosphate, and where at least some of the regions corresponding to the first, second, and third phases contact one another in the one or more integral units of the solid.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: October 3, 2017
    Assignee: Clean World Technologies Ltd.
    Inventor: Lupércio Tarcísio de Oliveira
  • Patent number: 9675459
    Abstract: To manufacture the implant a nanopowder of synthetic hydroxyapatite (Hap) is used having a hexagonal structure, average grain size in a range from 3 to 30 nm and the specific surface area greater than 200 m2/g. First the nanopowder is formed to the desired geometric shape, and then the shape is fixed. In the step of shape information the dried nanopowder is pressed in the mold under the pressure ranging from 50 Mpa to 2 GPa. In the step of fixing the pressed nanopowder at room temperature is subjected to the pressure rising from the ambient value to the peak value selected from a range of 1 to 8 GPa and to a temperature selected from a range of 100° C. to 600° C. for a period of time selected from a range from 30 seconds to 5 minutes. The density of thus produced implant, determined by helium method, is not less than 75% of the theoretical density.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: June 13, 2017
    Assignee: INSTYTUT WYSOKICH CISNIEN POLSKIEJ AKADEMII NAUK
    Inventors: Witold Łojkowski, Tadeusz Chudoba, Elżbieta Pietrzykowska, Aleksandra Kędzierska, Dariusz Smoleń, Wojciech Święszkowski, Krzysztof Kurzydłowski
  • Patent number: 9550010
    Abstract: Methods and articles of manufacture for treating patients with degenerative bone are provided. The methods are useful to improve bone quality in a localized area of a degenerative bone (e.g., osteopenic or osteoporotic bone), such as by improving BMD to be substantially similar to BMD in an average, healthy individual at the age of peak BMD. The methods can comprise forming a void in a localized area of the degenerative bone and filling the void with a bone regenerative material that causes generation of new, healthy, natural bone material. The articles of manufacture can comprise kits formed of various materials useful in the inventive methods for improving bone quality.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: January 24, 2017
    Assignee: Agnovos Healthcare, LLC
    Inventors: Olaf Schulz, James Howe, Rick Swaim, Bryan Huber, Joel Batts, David Harness, Ryan Belaney
  • Patent number: 9446170
    Abstract: The invention provides a particulate composition adapted for forming a bone graft substitute cement upon mixing with an aqueous solution, comprising i) a calcium sulfate hemihydrate powder, wherein the calcium sulfate hemihydrate is present at a concentration of at least about 50 weight percent based on the total weight of the particulate composition; ii) a monocalcium phosphate monohydrate powder; iii) a non-porous ?-tricalcium phosphate powder; and iv) a porous ?-tricalcium phosphate powder. Bone graft substitute cements made therefrom, a bone graft substitute kit comprising the particulate composition, methods of making and using the particulate composition, and articles made from the bone graft substitute cement are also provided.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: September 20, 2016
    Assignee: Agnovos Healthcare, LLC
    Inventors: Jon Moseley, Jamie MacDougall, Katie Harrigan
  • Patent number: 9408871
    Abstract: The present invention provides methods for inhibiting complement activation and uses thereof. More specifically, the present invention provides methods for inhibiting complement activation using inorganic polyphosphates of at least 10 phosphate units. The polyphosphates inhibit complement activation by one or more of: binding to the C6 complement protein, C1-esterase inhibitor (C1-inh), factor H or factor B; enhancing the activity of C1-inh; interfering with C1s-mediated cleavage of C2; destabilizing the C5b-6 complement protein complex; interfering with C5b,6 interaction with C7; interfering with binding of C5b-7 to a cell membrane; interfering with integration of C5b-7 into a cell membrane; interfering with binding of C5b-8 to a cell membrane; interfering with integration of C5b-8 into a cell membrane; destabilizing the membrane attack complex (MAC); or reducing the amount of C5b-9 deposited on a cell surface.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: August 9, 2016
    Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Edward Conway, Jing Zhao Cui, Jonathan Foley, Michael Krisinger, Joanne Matsubara, Linnette Ocariza, Jovian Wat
  • Patent number: 9180224
    Abstract: The invention provides a particulate composition adapted for forming a bone graft substitute cement upon mixing with an aqueous solution, including i) a calcium sulfate hemihydrate powder having a bimodal particle distribution and a median particle size of about 5 to about 20 microns, wherein the calcium sulfate hemihydrate is present at a concentration of at least about 70 weight percent based on the total weight of the particulate composition; ii) a monocalcium phosphate monohydrate powder; and iii) a ?-tricalcium phosphate powder having a median particle size of less than about 20 microns. Bone graft substitute cements made therefrom, a bone graft substitute kit comprising the particulate composition, methods of making and using the particulate composition, and articles made from the bone graft substitute cement are also provided.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: November 10, 2015
    Assignee: Agnovos Healthcare, LLC
    Inventors: Jon P. Moseley, Michael E. Carroll, Jonathan D. McCanless
  • Patent number: 9161967
    Abstract: The present invention relates to compositions and methods useful for treating structures of the vertebral column, including vertebral bodies. In one embodiment, a method for promoting bone formation in a vertebral body comprising providing a composition comprising a PDGF solution and a biocompatible matrix and applying the composition to at least one vertebral body. Promoting bone formation in a vertebral body, according to some embodiments, can increase bone volume, mass, and/or density leading to an increase in mechanical strength of the vertebral body treated with a composition of the present invention.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: October 20, 2015
    Assignee: BioMimetic Therapeutics, LLC
    Inventors: Charles E. Hart, Samuel E. Lynch, Conan S. Young, Dan Perrien
  • Patent number: 9144581
    Abstract: Compositions of reducing agents and carriers for producing a stable negative oxidation reduction potential in consumable materials are disclosed and claimed. Compositions of the invention find use in enhancing the hydration and anti-oxidant value of consumable materials such as foods, beverages and cosmetics, for example. Compositions of the invention also find use in water treatment, agricultural and scientific research applications. Methods for using and making the compositions are also within the scope of the invention.
    Type: Grant
    Filed: September 7, 2014
    Date of Patent: September 29, 2015
    Inventor: Dusan Miljkovic
  • Patent number: 9125966
    Abstract: The bone repair material comprises the following components: A) a first granular component with a diameter larger than 20 ?m chosen from the group of: calcium phosphate, calcium pyrophosphate, or calcium sulfate dihydrate; B) a second component chosen from the group of apatite powder with a particle diameter smaller than 1 ?m, (preferably smaller than 100 nm); and B) a third component comprising water or an aqueous solution, whereby C) the volume fraction of the second and third component represents at least 35 volume-% of the total bone repair material.
    Type: Grant
    Filed: November 15, 2005
    Date of Patent: September 8, 2015
    Assignees: DR. H.C. ROBERT MATHYS STIFTUNG, DEPUY SYNTHES PRODUCTS, INC.
    Inventors: Marc Bohner, Andrea Montali, Yvonne Bruderer
  • Publication number: 20150140118
    Abstract: The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.
    Type: Application
    Filed: November 14, 2014
    Publication date: May 21, 2015
    Inventors: Jean-Michel BOULER, Bruno BUJOLI, Pascal JANVIER, Ibrahim KHAIROUN, Jean-Noël ARGENSON
  • Publication number: 20150140117
    Abstract: The present invention generally relates to the field of bone substitute materials, and particularly to a bone substitute material that is bioactivated. More specifically, the present invention relates to a particular agent comprising citrate, citric acid, monobasic sodium phosphate, dextrose, and adenine for use in improving or promoting osseointegration of a bone substitute material, to a bone substitute material provided with a coating of said particular agent, and to a kit for use in a method of installing a bone substitute material comprising a bone substitute material as well as citrate, citric acid, monobasic sodium phosphate, dextrose, and adenine.
    Type: Application
    Filed: July 5, 2013
    Publication date: May 21, 2015
    Inventor: Günter Uhr
  • Publication number: 20150140116
    Abstract: The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices. The intrinsic bioactivity of the hydrogel matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implanted device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissue bulking.
    Type: Application
    Filed: January 30, 2015
    Publication date: May 21, 2015
    Inventors: Francis Vincent Lamberti, Richard Chris Klann, Ronald Stewart Hill
  • Patent number: 9034301
    Abstract: It is intended to provide a remineralization promoter for tooth enamel and a composition for an oral cavity, which can highly effectively promote the remineralization of tooth enamel and strongly inhibit dental caries. The remineralization promoter for tooth enamel and the composition for an oral cavity are characterized by containing amorphous hydroxyapatite and/or amorphized hydroxyapatite showing two peaks at 2?=31 to 35° in X-ray diffraction. The amorphized hydroxyapatite is obtained by reacting calcium salt with phosphate in an aqueous solution and drying the reaction solution at a temperature of 10 to 70° C.
    Type: Grant
    Filed: April 8, 2008
    Date of Patent: May 19, 2015
    Assignee: KABUSHIKI KAISHA SANGI
    Inventors: Shuji Sakuma, Tsutomu Ishizaki, Tadayoshi Arakawa
  • Publication number: 20150132404
    Abstract: A feed supplement mixture for performance horses provides a high protein nutritional supply while lowering stress experienced by the horse, reduces the onset of ulcers in the horse's digestive tract and treats ulcers in horses already afflicted with ulcers by the introduction of a quantity of thiamine to reduce stress and sodium bicarbonate to raise the ph level of the feed and the horse's stomach content.
    Type: Application
    Filed: October 30, 2014
    Publication date: May 14, 2015
    Inventor: George Aaron Custer
  • Publication number: 20150132353
    Abstract: A biomaterial in which the surface of a metal base is coated with a coating agent containing a composite of hydroxyapatite and collagen in which the c-axis of hydroxyapatite in the composite is oriented along collagen fibers is used.
    Type: Application
    Filed: April 19, 2013
    Publication date: May 14, 2015
    Inventors: Masanori Kikuchi, Kazuo Takakuda, Keiji Moriyama, Shoichi Suzuki, Masayoshi Uezono
  • Publication number: 20150125508
    Abstract: Disclosed are various bioactive grafts and/or biocompatible materials and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized. In another embodiment, an orthopedic implant includes an antibacterial polysaccharide. The implant may also include an osteostimulative agent.
    Type: Application
    Filed: January 16, 2015
    Publication date: May 7, 2015
    Inventors: Amit Prakash GOVIL, Christian GAMBOA
  • Publication number: 20150125808
    Abstract: An apparatus for mineralising a biological material includes an ultrasonic source, operable to generate an ultrasonic signal, an ultrasonic probe and one or more mineralising probes, operable to receive a mineralising agent. The mineralising agent is transferred from at least one mineralising probe to the biological material using the ultrasonic signal. Also disclosed are a mineralisation agent and a method of mineralising a biological material that includes the steps of: providing an ultrasound source, providing a mineralising agent, generating an ultrasonic signal from the ultrasound source, and applying the ultrasonic signal and the mineralising agent to the biological material separately, sequentially or simultaneously.
    Type: Application
    Filed: January 9, 2015
    Publication date: May 7, 2015
    Inventors: Nigel Pitts, Christopher Longbottom, Joseph Crayston
  • Publication number: 20150125537
    Abstract: There is provided a bone filler material comprising a plurality of particles, each particle comprising a biodegradable outer shell and an inner core. There is also provided an implant prepared from the same, methods of using the same and preparing the same.
    Type: Application
    Filed: November 7, 2014
    Publication date: May 7, 2015
    Inventors: Cho Hong James Goh, Pujiang Shi, Hee Kit Wong, Yong Zhang, Sunny Akogwu Abbah, Jun Li
  • Publication number: 20150118321
    Abstract: A process of preparing a glass comprising: (a) heating a mixture of precursor chemicals to a melt temperature to form a melt, the melt being characterized in that quenching the melt at or above a threshold temperature results in a spinodal phase seperation, and quenching the melt below the threshold temperature results in a droplet phase seperation; and (b) quenching the melt at or above the threshold temperature in a preheated mold to form the glass composition having the spinodal phase seperation.
    Type: Application
    Filed: October 28, 2014
    Publication date: April 30, 2015
    Inventors: Himanshu Jain, Roman Holovchak, Matthias M. Falk
  • Publication number: 20150119789
    Abstract: Biophotonic compositions comprising a photoactivator, a calcium phosphate mineral, hyaluronic acid and optionally glucosamine are disclosed. Said compositions have utility in the augmentation, repair and/or regeneration of bone when used in conjunction with actinic light of a wavelength absorbed by the photoactivator.
    Type: Application
    Filed: May 30, 2013
    Publication date: April 30, 2015
    Applicant: KLOX Technologies Inc.
    Inventors: Nikolaos Loupis, Remigio Piergallini
  • Patent number: 9011931
    Abstract: A composition used to facilitate healing of cold sores, fever blisters and canker sore that includes potassium, rubidium, zinc, calcium and sodium is provided. This composition is compounded into a polyethylene glycol ointment containing allantoin (0.5 to 2 percent) and camphor (0.1 to 3 percent) and/or menthol (0.1 to 1 percent). In another embodiment, a method to treat cold sores, fever blisters and canker sores is provided by applying an effective amount of this composition to cold sores, fever blisters and canker sores of a subject in need of treatment thereof.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: April 21, 2015
    Inventors: Libby Robinson, Mikel Hays
  • Publication number: 20150104490
    Abstract: A growth-inhibited hydroxyapatite is contained in agglomerates of prestructured collagen templates, wherein the prestructured collagen templates are denatured or broken up so that fibrillogenesis of the prestructured collagen templates is inhibited. Epitactic hydroxyapatite crystallites with a crystallite size below a critical nucleus radius are formed on the prestructured collagen templates.
    Type: Application
    Filed: December 19, 2014
    Publication date: April 16, 2015
    Inventors: Sascha Heinemann, Christiane Heinemann, Hartmut Worch, Thomas Hanke, Wolfgang Pompe
  • Publication number: 20150098998
    Abstract: The present disclosure provides compositions useful in regeneration of connective tissue, particularly bone. The compositions comprise a continuous matrix formed of a polypeptide crosslinked with a second polymer and further comprise particles of a porous, osteoconductive material dispersed in the continuous matrix. The composition can be provided in a dehydrated form. The disclosure further provides methods of preparing the composition in a clinically useful form, methods of using the composition in regenerating bone, and kits including the composition.
    Type: Application
    Filed: December 12, 2014
    Publication date: April 9, 2015
    Inventors: Francis Vincent Lamberti, Ronald Stewart Hill, Adam MacMillan, Edward Ahn, Brian Schlossberg, Stephen Capistron, William H. Lloyd
  • Patent number: 8999366
    Abstract: The present invention provides a synthetic non-resorbable silicon-containing calcium phosphate biomaterial having a microporosity of 23% by volume or greater, wherein the surface free energy of the biomaterial is 19 mJ/m.
    Type: Grant
    Filed: February 2, 2009
    Date of Patent: April 7, 2015
    Assignee: ApaTech Limited
    Inventors: Thomas Buckland, Charles Campion
  • Publication number: 20150086606
    Abstract: A bioresorbable and bioactive three-dimensional porous material made from bioresorbable polymers that can be combined with bioactive ceramics, producing a three-dimensional structure of interlinked pores containing additives capable of allowing the regeneration and formation of tissues, and a method for the production thereof is described.
    Type: Application
    Filed: September 28, 2012
    Publication date: March 26, 2015
    Inventors: Walter Israel Rojas Cabrera, Karina Nakajima, Luana Bendo
  • Publication number: 20150079146
    Abstract: The invention relates to the use of a bioactive glass material. For example, an autograft chip is wrapped in bioactive glass material for the treatment of bone injuries and bone defects in the body. The material can be in one or more of several forms, such as fibers, a fiber mesh, a sheet, or another shape. The material can be applied to hard tissues, such as bone.
    Type: Application
    Filed: April 5, 2013
    Publication date: March 19, 2015
    Applicant: NOVABONE PRODUCTS, LLC.
    Inventors: Gregory J. Pomrink, Zehra Tosun
  • Patent number: 8980328
    Abstract: A method for preparing carbonate apatite from natural bones. The method includes obtaining cancellous bone particles; treating the bone particles with hot water and an organic solvent; repeating the treating step at least once; drying the bone particles; and heating the bone particles at 500° C. to 620° C. for 10 to 50 hours.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: March 17, 2015
    Assignee: Collagen Matrix, Inc.
    Inventors: Shu-Tung Li, Hui-Chen Chen, Debbie Yuen
  • Publication number: 20150071983
    Abstract: Bioactive porous bone graft implants in various forms suitable for use in bone tissue regeneration and/or repair, as well as methods of use are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may be contained in polymer for enhanced clinical results and better handling.
    Type: Application
    Filed: November 17, 2014
    Publication date: March 12, 2015
    Inventors: Charanpreet S. BAGGA, Steve B. JUNG, Hyun W. BAE
  • Publication number: 20150064260
    Abstract: A collagen production enhancer for increasing the amount of collagen contained in the skin tissues, comprising calcium phosphate fine particles as effective ingredients.
    Type: Application
    Filed: November 10, 2014
    Publication date: March 5, 2015
    Inventors: Yasumichi KOGAI, Kazushige Karl KAWABE
  • Patent number: 8968797
    Abstract: Methods of preparing bioactive composites are described. Also described are methods of molding such composites. Shaped bodies comprising bioactive composites are further described.
    Type: Grant
    Filed: September 25, 2007
    Date of Patent: March 3, 2015
    Assignee: Orthovita, Inc.
    Inventors: James P. Murphy, Erik M. Erbe, Charanpreet S. Bagga, Marissa M. Darmoc
  • Publication number: 20150056264
    Abstract: The present invention discloses a coating for a medical implant, wherein at least a part of said coating contains an osseointegration agent and the same and/or a different part of the coating contains an antimicrobial metal agent.
    Type: Application
    Filed: September 2, 2014
    Publication date: February 26, 2015
    Inventors: Lu Gan, Marcus L. Scott, Shilesh C. Jani
  • Patent number: 8962037
    Abstract: The present invention discloses a method of manufacturing pure dicalcium phosphate ceramics or dicalcium phosphate/hydroxyapaite (HA) biphasic ceramics for medical applications in hard tissue areas to be used as implant materials. These ceramic implant materials are in granular form or in block form, and are prepared by using an acidic phosphate compound, a basic calcium phosphate compound comprising HA, and water. The dicalcium phosphate ceramic comprises either dicalcium phosphate dihydrate (CaHPO4.2H2O, DCPD) or dicalcium anhydrous (CaHPO4, DCPA). Wherein, when the acidic phosphate compound is provided in an amount stoichiometrically equal to or in excess relative to the basic calcium phosphate compound, a reaction product is the DCPD or DCPA ceramic; when the acidic phosphate compound is provided in the amount stoichiometrically less than the basic calcium phosphate compound, the reaction product is the DCPD/HA or DCPA/HA biphasic ceramic.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: February 24, 2015
    Assignee: Maxigen Biotech Inc.
    Inventors: Sung-Tsuen Liu, Sung-Ching Chen, Hui-Chun Lai, Wan-Ting Huang
  • Patent number: 8956594
    Abstract: Disclosed are dental compositions and methods. In accordance with one embodiment, a dental composition includes calcium, fluorine, which is generally present in the form of fluoride, and phosphate or another stabilizing anion. The composition is stable as against precipitation of calcium fluoride during transport and storage, but is unstable against the precipitation of calcium fluoride in the oral cavity of a human. In many embodiments, the amount of fluoride may be less than the amount of fluoride used in a comparable composition intended for a similar purpose. A dental method comprises applying the composition to the oral cavity of a patient, whereupon calcium fluoride precipitates from the composition.
    Type: Grant
    Filed: October 24, 2006
    Date of Patent: February 17, 2015
    Assignee: ADA Foundation
    Inventors: Laurence C. Chow, Shozo Takagi
  • Publication number: 20150044260
    Abstract: The present invention relates to nanoparticle aggregates comprising osteopontin (OPN) and one or more particles containing calcium and/or strontium and to their use for reducing or preventing biofilm growth or for removing biofilm. The invention furthermore relates to the use of the nanoparticle aggregates for treating, alleviating or preventing biofilm-related diseases.
    Type: Application
    Filed: March 27, 2013
    Publication date: February 12, 2015
    Inventors: Henrik Birkedal, Jakob Olsen, Jonas Skovgaard, Sebastian Schlafer, Rikke Louise Meyer, Bente Nyvad, Duncan Southerland, Peter Langborg Wejse
  • Patent number: 8951505
    Abstract: Disclosed are systems, methods, compositions and kits for mineralizing tissue, particularly dental tissue. The methods, compositions and kits may be used to strengthen and prevent weakening of the tissue. For example, the methods, compositions and kits may be used for treating and filling cavities in teeth caused by tooth decay.
    Type: Grant
    Filed: October 8, 2009
    Date of Patent: February 10, 2015
    Assignee: Georgia Health Sciences University Rsearch Institute, Inc.
    Inventors: David Henry Pashley, Franklin Chi-Meng Tay
  • Publication number: 20150037385
    Abstract: Ink formulations comprising bioactive particles, methods of printing the inks into three-dimensional (3D) structures, and methods of making the inks are provided. Also provided are objects, such as tissue growth scaffolds and artificial bone, made from the inks, methods of forming the objects using 3D printing techniques, and method for growing tissue on the tissue growth scaffolds. The inks comprise a plurality of bioactive ceramic particles, a biocompatible polymer binder, optionally at least one bioactive factor, and a solvent.
    Type: Application
    Filed: August 2, 2014
    Publication date: February 5, 2015
    Inventors: Ramille N. Shah, Adam E. Jakus
  • Publication number: 20150037386
    Abstract: A method for promoting bone formation is provided. More specifically, a method for promoting bone formation by promoting osteoclast formation is provided. In one embodiment, an implant comprising an implantable material and an osteoclast stimulating substance is provided.
    Type: Application
    Filed: May 12, 2014
    Publication date: February 5, 2015
    Applicant: Warsaw Orthopedic, Inc.
    Inventors: Lawrence A. Shimp, Keyvan Behnam, Guobao Wei, Abdulhafez A. Selim
  • Publication number: 20150030684
    Abstract: An irrigation resistant bone repair composition including a biocompatible or bioactive bone repair material and a mixture of non-random poly(oxyalkylene) block copolymers is described. Also, methods for treating a bone having a bone gap or a bone defect with the composition including a biocompatible or bioactive bone repair material and a mixture of non-random poly(oxyalkylene) block copolymers are also provided. Also, kits including the irrigation resistant bone repair composition including a biocompatible or bioactive bone repair material and a mixture of non-random poly(oxyalkylene) block copolymers are described.
    Type: Application
    Filed: October 13, 2014
    Publication date: January 29, 2015
    Inventors: Gregory J. Pomrink, Cecilia A. Cao, Zehra Tosun, David M. Gaisser
  • Publication number: 20150024064
    Abstract: A pKa buffered vitamin C composition which includes a base alkalizer composition mixed with vitamin C (calcium ascorbate or ascorbic acid). The base alkalizer composition can be approximately 24% to 40% and the ascorbic acid or calcium ascorbate can be approximately 76% to 60% by weight of the vitamin C composition. When this vitamin C composition is orally administered to an individual (in capsule or tablet form), a rapid neutralization of his stomach acid occurs followed by a sustained pH of 6.0 to 7.5 for a thirty minute to two hour period. This allows the ingredients to be absorbed in his stomach, while preventing unpleasant reactions in his stomach. The base alkalizer composition can include the combination of a calcium carbonate carrier which acts as a mild alkalizer, an hydroxide (magnesium or potassium) which acts as a fast alkalizer, and a phosphate (dicalcium or tricalcium) which acts as a moderate alkalizer and which also maintains the pH fairly stable over a twenty to forty minute time period.
    Type: Application
    Filed: October 3, 2014
    Publication date: January 22, 2015
    Inventors: Ricky L. Falkenberg, Harold L. Archibald
  • Publication number: 20150024063
    Abstract: Methods and apparatuses are provided for musculoskeletal tissue engineering. For example, a scaffold apparatus is provided which comprises microspheres of selected sizes and/or composition. The microspheres are layered to have a gradient of microsphere sizes and/or compositions. The scaffold provides a functional interface between multiple tissue types.
    Type: Application
    Filed: August 4, 2014
    Publication date: January 22, 2015
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Helen H. Lu, Jeffrey Spalazzi, Kathie Kionisio
  • Publication number: 20140377321
    Abstract: A three-dimensional biomedical device having an osteoinductive first area with a controlled porosity and a second area, which is produced by laser technology from a powder including one of ceramics, metals, metal alloys, bioactive glasses, lead zirconate titanate and biocompatible polymers, or mixtures thereof. The ratio of the porosities from the second area to the first area is equal or less than one, preferably from 0.001 to 0.9. A method for manufacturing the device for fitting in a bone defect, wherein a virtual object is designed with a computer-aid designed software, and the device is manufactured by laser technology including layering a powder onto a plate (7) so that a layer of a predetermined thickness is formed; the laser beam (8) selectively processes the powder to produce a processed layer, and, thus, layer after layer, the layers are joined together until the biomedical device is formed.
    Type: Application
    Filed: September 10, 2014
    Publication date: December 25, 2014
    Inventor: Didier NIMAL
  • Patent number: 8916208
    Abstract: A method is provided for promoting blood clotting. The area which is bleeding is contacted with an aluminophosphate molecular sieve. The molecular sieve preferably contains a substance which assists the clotting of blood. This substance is preferably Ca2+ ions, which are readily introduced into aluminophosphate molecular sieves. Preferred aluminophosphate molecular sieves include AlPO4-5 and VPI-5.
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: December 23, 2014
    Assignee: California Institute of Technology
    Inventor: Mark E. Davis
  • Publication number: 20140370065
    Abstract: An anhydrous suspension including a) particles of bioactive glass having a mean particle size less than or equal to 20 ?m; and an ester and/or amide with a molecular weight less than or equal to 100,000, and/or an alcohol. A gel obtainable by contacting the anhydrous suspension with water is also disclosed. Applications of the suspension and gel are also disclosed.
    Type: Application
    Filed: September 14, 2012
    Publication date: December 18, 2014
    Applicant: OY GRANULA AB LTD
    Inventors: Thomas Ahlnas, Johannes Ahlnas
  • Patent number: 8906411
    Abstract: A pre-compacted materiel comprising one or more calcium-containing compounds and one or more sugar alcohols, wherein the calcium-containing compound having a polycrystallic porous structure. The pre-compacted material is preferably obtained by roller compaction and is suitable for use in the further processing of the pre-compacted material into composition like e.g. tablets.
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: December 9, 2014
    Assignee: Takeda Nycomed AS
    Inventors: Poul Egon Bertelsen, Peder Mohr Olsen
  • Patent number: 8900640
    Abstract: A expandable porous body constituted by a compressed apatite/collagen composite, which expands by water absorption, and a method for producing an expandable, porous apatite/collagen composite, which expands by water absorption, comprising the steps of freezing a porous apatite/collagen composite impregnated with a liquid in a compressed state, and drying it.
    Type: Grant
    Filed: March 17, 2009
    Date of Patent: December 2, 2014
    Assignee: Hoya Corporation
    Inventor: Daisuke Shoji