Pyrophosphate Patents (Class 424/603)
  • Patent number: 10092587
    Abstract: The present invention relates to an antiviral composition comprising any one selected from the group consisting of chlorine, phosphocholine, cytidine triphosphate, CDP-choline, phosphorylcholine, and phosphatidylcholine. The antiviral composition is harmless to the human body and exhibits an excellent inhibitory effect on virus proliferation. Therefore, it can be applied to a pharmaceutical composition for preventing or treating viral diseases as well as a health functional food, a quasi-drug composition, and a feed composition for preventing or ameliorating viral diseases.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: October 9, 2018
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Dur Han Kwon, Mi Jin Jang, Jae Hyoung Song, Gansukh Enkhtaivan, Sei Ryang Oh
  • Patent number: 9931375
    Abstract: A method for direct therapeutic treatment of myocardial tissue in a localized region of a heart having a pathological condition. The method includes identifying a target region of the myocardium and applying material directly and substantially only to at least a portion of the myocardial tissue of the target region. The material applied results in a physically modification the mechanical properties, including stiffness, of said tissue. Various devices and modes of practicing the method are disclosed for stiffening, restraining and constraining myocardial tissue for the treatment of conditions including myocardial infarction or mitral valve regurgitation.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: April 3, 2018
    Assignee: CORMEND TECHNOLOGIES, LLC
    Inventors: William P. Santamore, Jeanne M. Lesniak
  • Patent number: 9403989
    Abstract: The invention provides a production process for a self-dispersible pigment, including a step of bonding a functional group containing a hydrophilic group to a particle surface of a pigment by causing a compound represented by the following general formula (1) (R1 is a halogen atom, R2 is an alkali metal, R3 is a single bond, —CO—, —CONH— or —SO2—, and R4 is a group having at least one of an aliphatic group and an aromatic group and being substituted with a hydrophilic group such as a carboxylic acid group) to react with the particle surface of the pigment:
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: August 2, 2016
    Assignee: Canon Kabushiki Kaisha
    Inventors: Taiki Watanabe, Koichi Suzuki, Ryuji Higashi
  • Patent number: 9040093
    Abstract: Described herein are materials and methods for increasing the osteoconductivity of a bone graft material, reducing the risk of infection at a surgical site, and increasing hemostasis. The bone graft materials described herein contain calcium phosphate and a form of chitin. In another embodiment the bone graft materials further comprises collagen. Chitin has been demonstrated to provide increased rate of new calcium phosphate growth, increased hemostasis, as well as antimicrobial properties. Various methods for manufacturing the bone graft materials described herein are also contemplated.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: May 26, 2015
    Assignee: Orthovita, Inc.
    Inventor: Kristi L. Wagner
  • Publication number: 20140271914
    Abstract: Described herein are materials and methods for increasing the osteoconductivity of a bone graft material, reducing the risk of infection at a surgical site, and increasing hemostasis. The bone graft materials described herein contain calcium phosphate and a form of chitin. In another embodiment the bone graft materials further comprises collagen. Chitin has been demonstrated to provide increased rate of new calcium phosphate growth, increased hemostasis, as well as antimicrobial properties. Various methods for manufacturing the bone graft materials described herein are also contemplated.
    Type: Application
    Filed: March 13, 2013
    Publication date: September 18, 2014
    Applicant: ORTHOVITA, INC.
    Inventor: Orthovita, Inc.
  • Patent number: 8742072
    Abstract: A biocompatible synthetic bone growth composition comprising a fibrillar collagen component and a calcium phosphate component. The composition is formed into particles, and then formed into a unitary article that may be provided at the site of a skeletal defect. An osteoinductive component may be further added, either before or after forming the unitary article. The composition may be formulated as a paste or putty and facilitates bone growth and/or repair.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: June 3, 2014
    Assignee: Zimmer Orthobiologics, Inc.
    Inventor: Kevin J. Thorne
  • Patent number: 8632683
    Abstract: A pharmaceutical composition for therapeutic administration of pyrophosphate for phosphate repletion may be in either liquid or solid form and may be usable as or usable for preparing a hemodialysis or peritoneal dialysis solution containing a pyrophosphate compound present in an amount that provides a concentration in the dialysis solution equivalent to an inorganic phosphorus concentration of at least 0.5 mg per deciliter.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: January 21, 2014
    Inventor: Ajay Gupta
  • Patent number: 8574609
    Abstract: Broad spectrum disinfecting and microbicidal compositions of biodegradable and environmentally friendly compositions containing esters formed from fatty organic alcohols and fatty carboxylic acids. These compositions display activities against the most resistant microbial forms including bacterial spores. The preparations can be used in health care, food processing, personal care and other industries where the use of harsh oxidizing chemicals is undesirable.
    Type: Grant
    Filed: May 2, 2011
    Date of Patent: November 5, 2013
    Inventor: John Alex Lopes
  • Patent number: 8486424
    Abstract: One embodiment includes a method including boiling unsalted butter over low heat until it appears golden to form purified butter; cooling the purified butter by removing it from the heat; straining or filtering the purified butter; refrigerating the purified butter for at least 24 hours; thoroughly blending together the elements of an organic carrier medium, wherein the organic carrier medium comprises the purified butter, olive oil, and honey; adding distilled water to the blended organic carrier medium; mixing the distilled water and the blended organic carrier medium at high speed; and adding at least one of sodium acid pyrophosphate, cornstarch, bismuth subnitrate, salicylic acid, or alkali metal salicylates, and mixing.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: July 16, 2013
    Inventor: Radmila Stojkoski
  • Publication number: 20120288569
    Abstract: Phosphate depletion, a physiological condition commonly seen in certain patient populations, including alcoholics, malnourished, acutely ill patients, patients receiving parenteral nutrition, patients being re-fed after prolong fasting, and dialysis patients, requires intravenous supplementation when oral repletion is not feasible. This invention provides a method and pharmaceutical composition for therapeutic administration of pyrophosphate, instead of phosphate, for phosphate or pyrophosphate repletion. During hemodialysis or peritoneal dialysis significant removal of phosphate and pyrophosphate occurs. Pyrophosphate depletion predisposes patients to vascular calcification. This invention further provides a method and pharmaceutical composition for therapeutic administration of pyrophosphate for phosphate or pyrophosphate repletion by addition of pyrophosphate to hemodialysis or peritoneal dialysis solutions.
    Type: Application
    Filed: May 22, 2012
    Publication date: November 15, 2012
    Inventor: Ajay Gupta
  • Patent number: 8273378
    Abstract: Dialysis solutions comprising pyrophosphates and methods of making and using the dialysis solutions are provided. In an embodiment, the present disclosure provides a dialysis solution comprising a stable and therapeutically effective amount of pyrophosphate. The dialysis solution can be sterilized, for example, using a technique such as autoclave, steam, high pressure, ultra-violet, filtration or combination thereof. The dialysis solution can be in the form of a concentrate.
    Type: Grant
    Filed: January 14, 2010
    Date of Patent: September 25, 2012
    Assignees: Baxter International, Inc., Baxter Healthcare S.A.
    Inventors: Bruce L. Riser, Paul Zieske, Sujatha Karoor, Himanshu D. Patel
  • Patent number: 8187467
    Abstract: Phosphate depletion, a physiological condition commonly seen in certain patient populations, including alcoholics, malnourished, acutely ill patients, patients receiving parenteral nutrition, patients being re-fed after prolonged fasting, and dialysis patients, requires intravenous supplementation when oral repletion is not feasible. This invention provides a method and pharmaceutical composition for therapeutic administration of pyrophosphate, instead of phosphate, for phosphate or pyrophosphate repletion. During hemodialysis or peritoneal dialysis significant removal of phosphate and pyrophosphate occurs. Pyrophosphate depletion predisposes patients to vascular calcification. This invention further provides a method and pharmaceutical composition for therapeutic administration of pyrophosphate for phosphate or pyrophosphate repletion by addition of pyrophosphate to hemodialysis or peritoneal dialysis solutions.
    Type: Grant
    Filed: December 30, 2004
    Date of Patent: May 29, 2012
    Inventor: Ajay Gupta
  • Patent number: 8158158
    Abstract: A biocidal composition is disclosed comprising composite particles, each of said composite particles containing a shell and a core, said core comprising a metal or a metal-containing compound wherein the metal is a moiety selected from the group consisting of zinc, copper, bismuth, silver, zirconium, and combinations thereof said shell comprising a pyrithione adduct comprising the reaction product of pyrithione with a portion of said core metal or metal compound. In one aspect, an anti-fouling composition is disclosed comprising (a) an anti-soft-fouling effective amount of copper pyrithione; and (b) an anti-hard-fouling effective amount of a copper-containing salt, or oxide or hydroxide thereof. The present invention also relates to a method of making an anti-fouling composition comprising particles of copper pyrithione and a copper-containing salt that is effective against hard-fouling and soft-fouling organisms.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: April 17, 2012
    Assignee: Arch Chemicals, Inc.
    Inventors: David F. Gavin, Craig Waldron, Robert J. Martin, George A. Polson
  • Publication number: 20110182995
    Abstract: The embodiments herein provide a dental and medical biomaterial and its use for sealing and/or filling the tooth and bone cavities. In the embodiments herein, the calcium salt, calcium oxide, calcium silicate, and calcium phosphate compounds are mixed with a water-base solution, and a bioactive phosphate and calcium enriched mixture is prepared. The mixture comprises high concentration of water-soluble calcium and phosphate, and consequently forms hydroxyapatite during and after setting. The dental/medical biomaterial is biocompatible, antibacterial and capable of forming an effective seal against reentrance of microorganisms into the filled cavity. The biomaterial is compatible to handle and set in an aqueous environment and to stimulate soft/hard tissue healing/generation/regeneration.
    Type: Application
    Filed: April 1, 2011
    Publication date: July 28, 2011
    Inventor: Saeed Asgary
  • Patent number: 7976876
    Abstract: The present invention relates to an anti-bacterial, anti-virus, and anti-fungus composition, its preparation and use. The composition of the present invention mainly includes the following three ingredients in an adequate ratio: (A) a metal compound having a catalytic function; (B) a mixture of a coenzyme having reducing ability and a quinone, and (C) an additive. The anti-bacterial, anti-virus, and anti-fungus composition of the present invention is capable of destroying viruses as well as killing bacterial and fungi. Therefore, the composition can be formulated as an aerosol and a film for applying to protection devices such as respirators, masks, gloves, filters, condoms, etc. The present composition can also be used in household, vehicle, hospital, school, restaurant, hotel, internet coffee shop for applying to filter of air-conditioner, tap, stool, interior of elevator and its keyboard.
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: July 12, 2011
    Assignee: Well-Being Biochemical Corp.
    Inventors: Jih-ru Hwu, Shwu-chen Tsay
  • Publication number: 20110135751
    Abstract: A pharmaceutical composition for therapeutic administration of pyrophosphate for phosphate repletion may be in either liquid or solid form and may be usable as or usable for preparing a hemodialysis or peritoneal dialysis solution containing a pyrophosphate compound present in an amount that provides a concentration in the dialysis solution equivalent to an inorganic phosphorus concentration of at least 0.5 mg per deciliter.
    Type: Application
    Filed: February 17, 2011
    Publication date: June 9, 2011
    Inventor: Ajay Gupta
  • Patent number: 7931910
    Abstract: The present invention provides an environmentally compatible, pesticidal composition and method for the control of insect pests. The composition includes two components. The first component is a chelating agent, a metal complex of a chelating agent, and mixtures thereof, and the second component is preferably a carrier material.
    Type: Grant
    Filed: January 17, 2007
    Date of Patent: April 26, 2011
    Assignee: W. Neudorff GmbH KG
    Inventor: Diana L. Parker
  • Publication number: 20110014258
    Abstract: The present invention provides a coating comprising a bioactive material and an antimicrobial agent, wherein the concentration of said antimicrobial agent varies throughout the thickness of the coating.
    Type: Application
    Filed: February 27, 2009
    Publication date: January 20, 2011
    Applicant: SMITH & NEPHEW, INC.
    Inventors: Lu Gan, Marcus L. Scott, Shilesh C. Jani, Laura S. Whitsitt
  • Patent number: 7858124
    Abstract: The present invention relates to an anti-bacterial, anti-virus, and anti-fungus composition, its preparation and use. The composition of the present invention mainly includes the following three ingredients in an adequate ratio: (A) a metal compound having a catalytic function; (B) ionic compound, and (C) an additive. The anti-bacterial, anti-virus, and anti-fungus composition of the present invention is capable of destroying viruses as well as killing bacterial and fungi. Therefore, the composition can be formulated as an aerosol and a film for applying to protection devices such as respirators, masks, gloves, filters, condoms, etc. The present composition can also be used in household, vehicle, hospital, school, restaurant, hotel, internet coffee shop for applying to filter of air-conditioner, tap, stool, interior of elevator and its keyboard.
    Type: Grant
    Filed: April 7, 2008
    Date of Patent: December 28, 2010
    Assignee: Well-Being Biochemical Corp.
    Inventors: Jih Ru Hwu, Shwu Chen Tsay
  • Patent number: 7780994
    Abstract: A process for the production of a composite material comprising collagen, brushite and one or more glycosaminoglycans, said process comprising the steps of providing an acidic aqueous solution comprising collagen, a calcium source and a phosphorous source and one or more glycosaminoglycans, and precipitating the collagen, the brushite and the one or more glycosaminoglycans together from the aqueous solution to form a triple co-precipitate.
    Type: Grant
    Filed: October 28, 2004
    Date of Patent: August 24, 2010
    Assignee: Cambridge Enterprise Limited
    Inventors: Andrew Lynn, Ruth Cameron, Serena Best, William Bonfield
  • Publication number: 20100119618
    Abstract: Dialysis solutions comprising pyrophosphates and methods of making and using the dialysis solutions are provided. In an embodiment, the present disclosure provides a dialysis solution comprising a stable and therapeutically effective amount of pyrophosphate. The dialysis solution can be sterilized, for example, using a technique such as autoclave, steam, high pressure, ultra-violet, filtration or combination thereof. The dialysis solution can be in the form of a concentrate.
    Type: Application
    Filed: January 14, 2010
    Publication date: May 13, 2010
    Applicants: BAXTER INTERNATIONAL INC.
    Inventors: Bruce L. Riser, Paul Zieske, Sujatha Karoor, Himanshu D. Patel
  • Patent number: 7658952
    Abstract: Dialysis solutions comprising pyrophosphates and methods of making and using the dialysis solutions are provided. In an embodiment, the present disclosure provides a dialysis solution comprising a stable and therapeutically effective amount of pyrophosphate. The dialysis solution can be sterilized, for example, using a technique such as autoclave, steam, high pressure, ultra-violet, filtration or combination thereof. The dialysis solution can be in the form of a concentrate.
    Type: Grant
    Filed: October 11, 2007
    Date of Patent: February 9, 2010
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Bruce L. Riser, Paul Zieske, Sujatha Karoor, Himanshu D. Patel
  • Patent number: 7628851
    Abstract: The present invention relates in general to implantable compositions, and method for preparing same, containing a calcium salt-containing component, optionally demineralized bone, a plurality of discrete fibers, optionally a flow additive, and optionally continuous reinforcing fibers or an array of organized fibers in the form of mesh. Advantageously, the discrete fibers have a specific aspect ratio (length/diameter) from about 50:1 to about 1000:1. The addition of a small amount of discrete fibers and/or the continuous reinforcing fibers or fiber mesh can cause drastic increases in certain mechanical properties including flexural strength, flexural toughness, and/or screw pullout strength.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: December 8, 2009
    Assignee: Synthes USA, LLC
    Inventors: Bryan Monro Armitage, Ira C Ison, Mark Thomas Fulmer, Sean Hamilton Kerr, Michael Lehmicke, Patrick Leamy, William Schiffer
  • Publication number: 20090269385
    Abstract: Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing sugar cross-linked collagen matrices of different densities. The composite matrices may be used in bone regeneration and/or augmentation applications. Scaffolds including glycated and/or reducing sugar cross-linked collagen exhibit improved support for cell proliferation and/or growth and/or differentiation. The denser collagen matrix of the composite matrices may have a dual effect initially functioning as a cell barrier and later functioning as an ossification supporting layer. The composite matrices, implants and scaffolds may be prepared using different collagen types and collagen mixtures and by cross-linking the collagen(s) using a reducing sugar or a mixture of reducing sugars. The composite matrices, implants and scaffolds may include additives and/or living cells.
    Type: Application
    Filed: April 30, 2009
    Publication date: October 29, 2009
    Inventors: Yuval ZUBERY, Arie GOLDLUST, Thomas BAYER, Eran NIR
  • Patent number: 7553362
    Abstract: A hydraulic cement for biomedical applications. The cement sets in-situ, hardening when exposed to water to produce nano-dispersed composite of calcium-silicate-hydrate gel mixed with hydroxyapatite. In comparison with prior cements, the composition provides high biocompatibility, high bioactivity and high biomechanical strength, due to the composite structure of the calcium silicate hydrate reinforced with co-precipitated particles of hydroxyapatite. Biocompatibility is also increased due to an absence of aluminum and magnesium in the composition. The cement is suitable for variety of applications, including dental implants, bone fixation, and bone repair.
    Type: Grant
    Filed: October 20, 2006
    Date of Patent: June 30, 2009
    Assignee: Innovative BioCeramix, Inc.
    Inventors: Donghui Lu, Shuxin Zhou
  • Patent number: 7517539
    Abstract: The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature and is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing. A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The supplementary material is in intimate contact with the hydroxyapatite material in an amount effective to impart a selected characteristic to the composite.
    Type: Grant
    Filed: October 16, 1997
    Date of Patent: April 14, 2009
    Assignee: Etex Corporation
    Inventors: Dosuk D. Lee, Christian Rey, Maria Aiolova, Aliassghar Tofighi
  • Patent number: 7501020
    Abstract: Calcium-strontium-hydroxyphosphate (strontium-apatite-) cement preparations are described, comprising a powder mixture, which contains molar quantities of the components calcium (Ca), strontium (Sr) and phosphate (P) in the mixture in the ranges 1.00<Ca/P?1.50 and 0<Sr/P<1.5, together with an alkali salt or an ammonium salt of phosphoric acid, and with water and/or an aqueous solution. The powder mixture particularly contains, as the Ca-component, Ca3(PO4)2 (TCP), and as the Sr-component SrHPO4 and/or Sr3(PO4)2 and optionally additional SrCO3. As the aqueous mixing solution for the formation of the strontium-apatite cement, an aqueous solution of an alkali salt or an ammonium salt of the phosphoric acid is suitable.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: March 10, 2009
    Assignee: Kyphon SARL
    Inventor: Robert Wenz
  • Patent number: 7494950
    Abstract: The present invention relates in general to implantable compositions, and method for preparing same, containing a calcium salt-containing component, optionally demineralized bone, a plurality of discrete fibers, optionally a flow additive, and optionally continuous reinforcing fibers or an array of organized fibers in the form of mesh. Advantageously, the discrete fibers have a specific aspect ratio (length/diameter) from about 50:1 to about 1000:1. The addition of a small amount of discrete fibers and/or the continuous reinforcing fibers or fiber mesh can cause drastic increases in certain mechanical properties including flexural strength, flexural toughness, and/or screw pullout strength.
    Type: Grant
    Filed: September 7, 2004
    Date of Patent: February 24, 2009
    Assignees: Synthes (U.S.A.), Synthes GmbH
    Inventors: Bryan Monro Armitage, Ira Ison, Mark Fulmer, Sean Kerr, Michael Lehmicke, Patrick Leamy, William Schiffer
  • Patent number: 7419680
    Abstract: Compositions useful in the prevention and treatment of osteoporosis and for bone and fracture repair. Slow-releasing calcium phosphate-based materials are disclosed, incorporating Mg, Zn, F and carbonate, which will promote bone formation and inhibit bone resorption and thus be agents for the cited uses.
    Type: Grant
    Filed: September 28, 2004
    Date of Patent: September 2, 2008
    Assignee: New York University
    Inventor: Racquel Z. LeGeros
  • Publication number: 20080187601
    Abstract: The invention relates to a polyoxometalate topical composition for removing a contaminant from an environment, comprising a topical carrier and at least one polyoxometalate, with the proviso that the polyoxometalate is not H5PV2Mo10O40; K5Si(H2O)MnIIIW11O39; K4Si(H2O)MnIVW11O39; or K5CoIIIW12O40. The invention further relates to a method for removing a contaminant from an environment, comprising contacting the polyoxometalate topical composition of the present invention with the environment containing the contaminant for a sufficient time to remove the contaminant from the environment. The invention further relates to a method for removing a contaminant from an environment, comprising contacting a polyoxometalate powder or a polyoxometalate coating with the environment containing the contaminant for a sufficient time to remove the contaminant from the environment.
    Type: Application
    Filed: December 7, 2006
    Publication date: August 7, 2008
    Inventors: Craig L. Hill, Ling Xu, Jeffrey T. Rhule, Eric A. Boring
  • Patent number: 7387799
    Abstract: The present invention relates to an anti-bacterial, anti-viral, and anti-fungus composition, its preparation and use. The composition of the present invention mainly includes the following three ingredients in an adequate ratio: (A) a metal compound having catalytic function; (B) ionic compound, and (C) an additive. The anti-bacterial, anti-virus, and anti-fungus composition of the present invention is capable of destroying viruses as well as killing bacterial and fungi. Therefore, the composition can be formulated as an aerosol and a film for applying to protection devices such as respirators, masks, gloves, filters, condoms, etc. The present composition can also be used in household, vehicle, hospital, school, restaurant, hotel, internet coffee shop for applying to filter of air-conditioner, tap, stool, interior of elevator and its keyboard.
    Type: Grant
    Filed: July 29, 2003
    Date of Patent: June 17, 2008
    Assignee: Well-Being Biochemical Corp.
    Inventors: Jih-Ru Hwu, Shwu-Chen Tsay
  • Publication number: 20080031973
    Abstract: An antislip agent directly applicable to the hands for a short-term negation of the effects of perspiration on grip security. The hands will also become slightly sticky for 1 to 2 minutes upon use, after which time the effect of this invention will disappear, allowing one to then decide whether continued use is helpful in the setting, e.g. a strong grip was required for a batter's swings in a baseball game but is not required at other times in the game. The composition can be made in solid or liquid form.
    Type: Application
    Filed: August 5, 2006
    Publication date: February 7, 2008
    Inventor: Soon Myoung Lee
  • Publication number: 20080026023
    Abstract: A textile material for management of skin health complications associated with skin folds includes a disposable textile of selected dimensions, impregnated with a selected concentration of an antimicrobial silver complex. The disposable textile is designed to be placed within a skin fold for management of skin health complications associated therewith. A method of use of the disposable textile material includes the steps of performing a routine skin inspection, selectively using a skin cleanser to topically clean the skin fold, selectively using an antifungal powder to topically cover the skin fold, determining approximate dimensions of the skin fold, providing the textile material dimensioned such that at least one selected portion is exposed to air outside of the skin fold, and placing the textile material over skin of the skin fold such that the skin fold may envelope the textile material with the at least one selected portion thereof being exposed to air.
    Type: Application
    Filed: July 31, 2006
    Publication date: January 31, 2008
    Inventors: Kevin C. Tauer, Charles E. Boyer, Ronald J. Schwartz, Catherine M. Garvin
  • Patent number: 7297349
    Abstract: The present invention relates to a copper-containing formulation for plant disease-control which comprises divalent copper and polyphosphate residues, wherein the amount of the polyphosphate residues per one chemical equivalent of the divalent copper is higher than one chemical equivalent. The copper-containing formulation of the present invention shows an excellent disease-control effect without causing any chemical injury of the plant.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: November 20, 2007
    Assignees: Riken, Otsuka Chemical Co., Ltd
    Inventors: Yutaka Arimoto, Akiko Hagiwara, Kiyoshi Uchida, Yoshifumi Ota
  • Publication number: 20070258910
    Abstract: Provided herein are methods to remineralize the demineralized areas of hard tissues. The disclosure provides for remineralizing methods and systems that utilize a jet stream laden with particles comprising at least calcium and phosphorus to remove demineralized zone and implant particles within the hard tissue to stimulate remineralization. Some aspects of the disclosure can be advantageously used to remineralize one or more of enamel, dentin, and bone.
    Type: Application
    Filed: May 8, 2007
    Publication date: November 8, 2007
    Inventor: Dwayne D. Arola
  • Patent number: 7273523
    Abstract: Calcium-strontium-hydroxyphosphate (strontium-apatite-) cement preparations are described, comprising a powder mixture, which contains molar quantities of the components calcium (Ca), strontium (Sr) and phosphate (P) in the mixture in the ranges 1.00<Ca/P?1.50 and 0<Sr/P<1.5, together with an alkali salt or an ammonium salt of phosphoric acid, and with water and/or an aqueous solution. The powder mixture particularly contains, as the Ca-component, Ca3(PO4)2 (TCP), and as the Sr-component SrHPO4 and/or Sr3(PO4)2 and optionally additional SrCO3. As the aqueous mixing solution for the formation of the strontium-apatite cement, an aqueous solution of an alkali salt or an ammonium salt of the phosphoric acid is suitable.
    Type: Grant
    Filed: December 6, 2004
    Date of Patent: September 25, 2007
    Assignee: Kyphon Inc.
    Inventor: Robert Wenz
  • Patent number: 7070941
    Abstract: The invention provides methods and compositions for azide tagging of biomolecules. In one embodiment of the invention, proteins are tagged by metabolic incorporation of prenylated azido-analog substrates. Examples of such analogs are azido farnesyl diphosphate and azido farnesyl alcohol. The azido moiety in the resulting modified proteins provides an affinity tag, which can be chemoselectively captured by an azide-specific conjugation reaction, such as the Staudinger reaction, using a phosphine capture reagent. When the capture agent is biotinylated, the resulting conjugates can be detected and affinity-purified by streptavidin-linked- HRP and streptavidin-conjugated agarose beads, respectively. The invention allows detection and isolation of proteins with high yield, high specificity, and low contamination without harsh treatment of proteins.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: July 4, 2006
    Assignee: Board of Regents, The University of Texas System
    Inventors: Yingming Zhao, John R. Falck
  • Patent number: 7060301
    Abstract: The present invention relates to in situ compositions of mono- or diester dicarboxylates, methods employing these in situ compositions, and methods of making these in situ compositions. More particularly, the invention relates to mono- or diester dicarboxylate antimicrobial compositions that can reduce the population of microbes on various surfaces such as facilities, containers, or equipment found in food, beverage, or pharmaceutical processing, or in food, beverage, or pharmaceutical industries, at temperatures between about ?70° C. to about 100° C.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: June 13, 2006
    Assignee: Ecolab Inc.
    Inventors: Guang-Jong Jason Wei, Larry A. Grab, Robert Dale Hei, Teresa C. Podtburg
  • Patent number: 6964782
    Abstract: Disclosed are several preferred embodiments of hydrogen peroxide which are packaged with ease of use and extended shelf-life in mind. The embodiments include foam, mist, gel, and disposable towelette forms of H2O2. Optional ingredients of topical pain relievers and skin protectants are also disclosed, as are their methods of use.
    Type: Grant
    Filed: July 7, 2003
    Date of Patent: November 15, 2005
    Assignee: Tec Labs, Inc.
    Inventors: Robert Lee Smith, Steven Dale Smith, Wendy S. Langley, John Mark Christensen, Vernon W. Smith
  • Patent number: 6956054
    Abstract: Treatment of warm-blooded animals having a tumor or non-malignant hypervascularation, by administering a sufficient amount of a cytotoxic agent formulated into a phosphate prodrug form having substrate specificity for microvessel phosphatases, so that microvessels are destroyed preferentially over other normal tissues, because the less cytotoxic prodrug form is converted to the highly cytotoxic dephosphorylated form.
    Type: Grant
    Filed: August 14, 2002
    Date of Patent: October 18, 2005
    Assignees: Baylor University, OXiGENE, Inc.
    Inventors: Ronald W. Pero, David Sherris, Kevin G. Pinney, Vani P. Mocharla, Zhi Chen
  • Patent number: 6953594
    Abstract: The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature and is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing. A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The supplementary material is in intimate contact with the hydroxyapatite material in an amount effective to impart a selected characteristic to the composite.
    Type: Grant
    Filed: November 23, 2001
    Date of Patent: October 11, 2005
    Assignee: Etex Corporation
    Inventors: Dosuk D. Lee, Christian Rey, Maria Aiolova, Aliassghar Tofighi
  • Patent number: 6825155
    Abstract: A dental resin material mixed with a composition containing, as a maincomponent, titanium dioxide whose surface has been partly coated with apatite. In the dental resin material, it is preferable that anatase-, rutile-, brookit-type titanium dioxide or a mixture of these components is used as the titanium dioxide. The apatite for partial coating of titanium dioxide is produced by immersing powdery titanium dioxide in a pseudo body fluid and stirring the immersed titanium dioxide approximately at the same temperature as a human body temperature, i.e., 36° C. In this instance, it is important that the apatite is deposited in the form of platy crystals of less than 2 mm in thickness to cover 0.001-10% of the surface of titanium dioxide.
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: November 30, 2004
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Toru Nonami, Takayuki Kumagai, Hiroshi Taoda
  • Patent number: 6803057
    Abstract: An acidic aqueous hydrogen peroxide solution is provided with improved disinfectant activity. Concentrated solutions preferably contain up to about 8 wt./wt. % H2O2 and as-used concentrations contain about 0.5% wt./wt. % H2O2. The solution also contains from 0.05 to 8.0 wt./wt. % of at least one phosphorous-based acid, e.g. phosphoric acid and/or a phosphonic acid with from 1 to 5 phosphonic acid groups, and from 0.02 to 5 wt./wt. % of at least one anionic surfactant. The surfactant is selected from C8 to C16 alkyl aryl sulfonic acids, sulfonated C12 to C22 carboxylic acids, C8 to C22 alkyl diphenyl oxide sulfonic acids, naphthalene sulfonic acids, C8 to C22 alkyl sulfonic acids, and alkali metal and ammonium salts thereof, and alkali metal C8 to C18 alkyl sulfates, and mixtures thereof. Most preferably the solution has an emulsifier and/or hydrotrope, e.g. an alkylated sulfonated diphenyl oxide salt, an alkyl aryl polyoxyethylene surfactant, and/or a polyoxyethylene surfactant.
    Type: Grant
    Filed: December 28, 2001
    Date of Patent: October 12, 2004
    Assignee: Virox Technologies Inc.
    Inventors: Jose A. Ramirez, Michael J. Rochon
  • Patent number: 6779468
    Abstract: A method of administering iron to dialysis patients is accomplished by infusion of a noncolloidal ferric compound, soluble in hemodialysis or peritoneal dialysis solutions, by the process of dialysis. A pharmaceutical composition is provided consisting essentially of dialysis solution including a soluble noncolloidal ferric compound, preferably ferric pyrophosphate.
    Type: Grant
    Filed: September 8, 1999
    Date of Patent: August 24, 2004
    Inventor: Ajay Gupta
  • Patent number: 6770303
    Abstract: Phosphorus acid derivatives and the like are used as an amplifier (potentiator) of plant defense responses induced by other materials (elicitors).
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: August 3, 2004
    Assignee: Bayer Cropscience S.A.
    Inventors: Bernard Fritig, Marguerite Kopp, Patrick Saindrenan, Marie-Pascale Latorse, Gilbert Labourdette
  • Patent number: 6764692
    Abstract: A method of treating laminitis in a horse is disclosed, comprising administering to the horse a naturally chelated trace mineral composition; promoting healthy skin, hair and hoof tissue. A method of reducing dietary intake is also disclosed, comprising administering to a horse in need thereof, effective amounts of a naturally chelated trace mineral composition. A method of preparing the chelated trace mineral composition from ocean seabed rock is further disclosed, as well as the chelated trace mineral composition.
    Type: Grant
    Filed: August 27, 2002
    Date of Patent: July 20, 2004
    Inventor: Carlos Cortelezzi
  • Patent number: 6726936
    Abstract: An antimicrobial agent includes silver-chloro complex salts and chloride, and further oxidizing agents such as sodium hypochlorite or sodium chlorite. As a result, it is possible to provide the antimicrobial agent having immediate and residual disinfecting and antimicrobial effects on bacteria and molds of a wide variety of species and capable of demonstrating instantaneous deodorizing effect. The antimicrobial agent includes the silver-chloro complex salts and chloride, and further a compound, for example, such as alcohols or surfactants, which has compatibility with a solvent such as water which dissolves the chloride. As a result, it is possible to provide the antimicrobial agent which can be used conveniently at the stored concentration, and which has immediate effect and cleansing ability without causing rust or deposition of salts in use.
    Type: Grant
    Filed: December 19, 2000
    Date of Patent: April 27, 2004
    Assignees: Sumitomo Metal Mining Co., Ltd., Yokosawa Metal Co., Ltd.
    Inventors: Satoshi Asano, Yuuichi Yokosawa, Yasutaka Soeda
  • Publication number: 20040076685
    Abstract: The invention describes a method of preparing alpha- or beta-tricalcium phosphate, brushite (CaHPO4.2H2O), calcium pyrophosphate (Ca2P2O7) or hydroxyapatite (Ca5(PO4)3(OH)) or mixtures thereof in the form of morsels or granules via gelatin processing. These morsels or granules can be used as bone or tooth fillers or bone substitutes in applications, especially when higher rates of resorption or taking part in the bone remodelling processes of the implanted material are desired.
    Type: Application
    Filed: July 11, 2003
    Publication date: April 22, 2004
    Applicant: Merck Patent GmbH
    Inventor: Ahmet Cuneyt Tas
  • Patent number: 6723349
    Abstract: The invention relates to a polyoxometalate topical composition for removing a contaminant from an environment, comprising a topical carrier and at least one polyoxometalate, with the proviso that the polyoxometalate is not H5PV2Mo10O40; K5Si(H2O)MnIIIW11O39; K4Si(H2O)MnIVW11O39; or K5CoIIIW12O40. The invention further relates to a method for removing a contaminant from an environment, comprising contacting the polyoxometalate topical composition of the present invention with the environment containing the contaminant for a sufficient time to remove the contaminant from the environment. The invention further relates to a modified polyoxometalate, wherein the modified polyoxometalate comprises the admixture of (1) a polyoxometalate and (2) a cerium compound, a silver compound, a gold compound, a platinum compound, or a combination thereof.
    Type: Grant
    Filed: October 11, 2000
    Date of Patent: April 20, 2004
    Assignee: Emory University
    Inventors: Craig L. Hill, Ling Xu, Jeffrey T. Rhule, Eric A. Boring
  • Patent number: 6689275
    Abstract: A method of replacing iron losses during dialysis of patients is accomplished by infusion of a noncolloidal ferric compound, soluble in hemodialysis solutions, during dialysis. A pharmaceutical composition is provided consisting essentially of dialysis solution including a soluble noncolloidial ferric compound, preferably ferric pyrophosphate.
    Type: Grant
    Filed: December 31, 1996
    Date of Patent: February 10, 2004
    Inventor: Ajay Gupta