Nitrite Patents (Class 424/619)
  • Patent number: 9700578
    Abstract: It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: July 11, 2017
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Acting through the Louisiana State University Health Sciences Center, The UAB Research Foundation, Loma Linda University, Wake Forest University
    Inventors: Mark T. Gladwin, Alan N. Schechter, David J. Lefer, Rakesh P. Patel, Christian J. Hunter, Gordon G. Power, Daniel B. Kim-Shapiro, Ryszard Marek Pluta, Edward H. Oldfield, Richard O. Cannon, III
  • Patent number: 9579413
    Abstract: The invention relates to a multi-layered wound dressing, particularly for the moist wound treatment, comprising a first layer as a wound contact layer, which contains an aqueous hydrogel matrix, and at least a second absorbing layer. The hydrogel matrix comprises 37 to 43% by weight of propylene glycol, a prepolymer with isophorone diisocyanate groups and a diamine on the basis of polyethylene oxide in an amount of a total of 12 to 16.5% by weight, 0 to 5% by weight of an inorganic chloride, and the remainder water, wherein the ratio of the reactive groups of isocyanate to the amine groups of the diamine should be 1.25 to 1.35.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: February 28, 2017
    Assignee: PAUL HARTMANN AG
    Inventors: Martin Junginger, Julie Horny
  • Publication number: 20150110844
    Abstract: A metal implant for use in a surgical procedure is provided with a surface layer that is integral with the metal substrate, and which incorporates a biocidal material. The surface layer may be grown from the metal substrate, by anodising, and the biocidal material incorporated in it by ion exchange. Alternatively the layer may be deposited by electroplating, followed by diffusion bonding so as to become integral with the metal substrate. In either case, silver is a suitable biocidal material; and both the release rate and the quantity of biocidal material should be low to avoid toxic effects on body cells. Electropolishing the surface before formation of the surface layer is also beneficial, and this may be achieved by electropolishing.
    Type: Application
    Filed: December 23, 2014
    Publication date: April 23, 2015
    Applicant: Acentus Medical Limited
    Inventors: Martin Edward Lee Pickford, Andrew Derek Turner
  • Publication number: 20150001066
    Abstract: A wipe for anti-microbial disinfecting includes a flexible substrate and an anti-microbial ion source integrated on the substrate. The flexible substrate is made entirely or in part of woven fiber cloth, non-woven fiber cloth, woven synthetic cloth, non-woven synthetic cloth, or natural fiber cloth. The anti-microbial ion source is configured to dissolve in an aqueous solution to form an anti-microbial solution. The flexible substrate is configured to absorb the anti-microbial solution for use in cleaning.
    Type: Application
    Filed: June 25, 2014
    Publication date: January 1, 2015
    Inventor: Ashok V. Joshi
  • Patent number: 8920852
    Abstract: Provided herein are pharmaceutically acceptable sodium nitrite and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-volatile organic carbon in a sodium nitrite-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium nitrite. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium nitrite.
    Type: Grant
    Filed: October 1, 2013
    Date of Patent: December 30, 2014
    Assignee: Hope Medical Enterprises, Inc.
    Inventors: Craig Sherman, Anthony James Lepine, Catherine Marie Smith, Kevin Robert Wirtz, Erich Schulze
  • Publication number: 20140356406
    Abstract: Described herein are glass or glass-ceramic articles having improved antimicrobial efficacy. Further described are methods of making and using the improved articles. The improved articles generally include a glass or glass-ceramic substrate, a compressive stress layer that extends inward from a surface of the glass or glass-ceramic substrate to a first depth therein, and an antimicrobial agent-containing region that extends inward from the surface of the glass or glass-ceramic substrate to a second depth therein. The antimicrobial agent-containing region may include at least one of a plurality of ion exchanged-copper ions and a plurality of ion exchanged-silver ions, arranged in a predetermined portion of the surface.
    Type: Application
    Filed: May 20, 2014
    Publication date: December 4, 2014
    Applicant: CORNING INCORPORATED
    Inventors: Mallanagouda Dyamanagouda Patil, Christine Coulter Wolcott
  • Publication number: 20140348891
    Abstract: The present invention refers to new active nanocomposite materials, comprising a matrix and additives. The present invention also describes a process for obtaining these nanocomposite materials and their use in various industry sectors.
    Type: Application
    Filed: August 7, 2014
    Publication date: November 27, 2014
    Applicant: NANOBIOMATTERS, S.L.
    Inventors: Jose Maria LAGARON CABELLO, Maria Antonieta BUSOLO PONS, Maria Eugenia NUNEZ CALZADO
  • Patent number: 8852647
    Abstract: The present invention relates to compositions comprising a combination of pyrimethanil, or a salt thereof, together with one or more silver salts selected from silver acetate, silver alginate, silver azide, silver citrate, silver lactate, silver nitrate, silver sulfate, silver chloride, silver thiocyanate, silver-sodium-hydrogen-zirconium phosphate, silver sulfadiazine, silver cyclohexanediacetic acid and disilver 2,5-dichloro-3,6-dihydroxy-2,5-cyclohexadiene-1,4-dione; in respective proportions to provide a synergistic biocidal effect. Another suitable silver component (II) is nano-silver particles, typically with a particle size of 1-1000 nm. Compositions comprising these combinations are useful for the protection of any living or non-living material against deterioration due to the action of microorganisms such as bacteria, fungi, yeasts, algae, and the like.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: October 7, 2014
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Dany Leopold Jozefien Bylemans, Jan Pieter Hendrik Bosselaers, Mark Arthur Josepha Van Der Flaas
  • Publication number: 20140227370
    Abstract: A polysaccharide fibre useful in biomedical applications such as wound management is made as a bicomponent fibre with alginate and psyllium polymers. An antimicrobial silver salt may be incorporated. The fibre may be made by extruding an aqueous mixture of alkaline-solubilised psyllium and sodium alginate into a calcium chloride bath.
    Type: Application
    Filed: December 5, 2012
    Publication date: August 14, 2014
    Applicant: University of Bolton
    Inventors: Mohsen Miraftab, Rashid Masood
  • Publication number: 20140154335
    Abstract: An antimicrobial packaging polymer and its method of use, and more particularly to a contact antimicrobial such as metal or metal ions covalently bound to a polymeric material that may be suitable in a variety of applications such as film and container packaging of perishable items, medical equipment and devices, environmental, hygienic and sanitary applications, as well as other consumer and commercial use.
    Type: Application
    Filed: December 2, 2013
    Publication date: June 5, 2014
    Applicant: Whitehall Products, LLC
    Inventor: Michael Russo
  • Patent number: 8722081
    Abstract: A hemostatic textile material to stop bleeding comprising a dialdehyde cellulose (DAC) carrier wherein the degree of oxidation of the dialdehyde cellulose varies from about 1.5% to 12%; and a blood coagulation factor selected from the group consisting of chitosan and gelatin; the blood coagulation factor being chemically immobilized thereon; and further optionally comprising a bacteriolytic agent selected from the group consisting of a lysozyme enzyme, silver nitrate, and chlorhexidine; and further optionally comprising a selected component that prevents hemolysis, the component selected from the group consisting of tranexamic acid or ?-aminocaproic acid chemically immobilized thereon.
    Type: Grant
    Filed: October 15, 2007
    Date of Patent: May 13, 2014
    Inventors: Vladimir N. Filatov, Vladimir Ryltsev, Zidkiyahu Simenhaus
  • Publication number: 20140120148
    Abstract: An antimicrobial material, antimicrobial devices and method of reducing or eliminating microorganisms from a fluid susceptible to contain microorganisms is presented. The antimicrobial material is comprised of a porous activated ceramic substrate; a titanium dioxide layer covalently bound to the ceramic substrate; and a silver salt layer covalently bound to the titanium oxide layer. This antimicrobial material is used in the antimicrobial devices and methods to reduce or eliminate microorganisms in fluid.
    Type: Application
    Filed: January 8, 2014
    Publication date: May 1, 2014
    Applicant: CARDPOOL
    Inventor: Cristian Vasile Chis
  • Publication number: 20140010855
    Abstract: This invention relates to antimicrobial polymeric articles containing metal salt particles having a particle size of less than about 200 nm dispersed throughout the polymer and methods for their production.
    Type: Application
    Filed: June 12, 2013
    Publication date: January 9, 2014
    Inventors: Shivkumar Mahadevan, Amit Khanolkar, Osman Rathore, Yongcheng Li, Craig W. Walker, Thomas R. Rooney
  • Publication number: 20130330416
    Abstract: Technologies are described herein for styptic compounds comprising a hemostatic or styptic agent suspended within a hydrophobic carrier medium. Example carrier mediums may include waxes, lipids, oils, or combinations thereof. The compound may be a semisolid at room temperature and soft enough to be easily dispensed and formed into or onto bleeding tissue of an animal or human. The hydrophobic qualities of the carrier medium can protect the styptic agent from absorbing moisture. The carrier medium can mechanically support positioning treatments adjacent to the bleeding tissue. The carrier medium can further serve to mechanically seal the tissue to aid in hemostasis while also protecting the tissue from debris and contamination. The carrier medium can aid in maintaining moisture within the tissue. Slurry-based manufacturing processes can support a substantially homogeneous dispersal of styptic agent throughout the carrier medium.
    Type: Application
    Filed: June 8, 2012
    Publication date: December 12, 2013
    Inventor: Robert J. Greenwald
  • Publication number: 20120301553
    Abstract: A colloidal dispersion having carrier particles of silica having a particle size from 3 nm to 100 nm to which silver ions have been adsorbed, preferably in an amount of 0.0005-5 silver ions per nm2 of silica particle surface. The surface of the carrier particles of silica suitably contains aluminumsilicate sites. It also relates to a process for making a colloidal dispersion comprising providing a silica sol, adding a solution of silver nitrate to the silica sol under agitation yielding a colloidal dispersion with silver ions adsorbed on the surface of the silica particles. The dispersion is usable as a biocide in e.g. coatings, adhesives and sealants, in surface treatment and impregnation of organic materials, in surface treatment and impregnation of inorganic materials, in textiles, garments and shoes, in medical disposables, in plastics and rubbers, in water and air purification, and in crop protection.
    Type: Application
    Filed: September 20, 2010
    Publication date: November 29, 2012
    Applicant: PREBONA AB
    Inventor: Jan-Erik Otterstedt
  • Publication number: 20120282348
    Abstract: An antimicrobial therapeutic hydrogel composition comprises a pharmaceutical and/or medical grade silver salt, and an Aloe vera gel or extract. The composition could also include stabilizing agents, a non-ionic surfactant, polyol, and hydrophilic hygroscopic polymers. The resulting product has potent antimicrobial activity against bacteria, protozoa, fungi and viruses. The antimicrobial therapeutic composition can serve as a treatment for burns and as a wound/lesion dressing that either donates or receives moisture to provide a physiologic environment for accelerated wound healing and the relief of pain.
    Type: Application
    Filed: May 5, 2011
    Publication date: November 8, 2012
    Inventors: Kenneth M. Yates, Celia A. Proctor, Dan H Atchley
  • Publication number: 20120225126
    Abstract: Disclosed are a solid state synthesis method of silver nanoparticles, and silver nanoparticles synthesized thereby. The method includes mixing a silver salt and a water soluble polymer acting as both a reducing agent and a protecting agent to produce a solid mixture, and milling the solid mixture by a high-speed vibration milling process to form silver nanoparticles within the water soluble polymer. According to the present invention, silver nanoparticles can be easily and simply produced in a solid state through high speed vibration milling, thereby reducing costs for industrial production and transportation of silver nanoparticles. In addition, the synthesized silver nanoparticles can be used for a long time since the silver nanoparticles are stable in a solid state for 1 year or more.
    Type: Application
    Filed: November 9, 2010
    Publication date: September 6, 2012
    Applicant: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Kurt E. Geckeler, Dipen Debnath, Chorong Kim, Sung Ho Kim
  • Patent number: 8192765
    Abstract: An antimicrobial and chemical deactivating composition for use in a liquid medium or for incorporation into a coating, structural plastic materials, thin microporous membranes, textiles and sponges. The composition includes macrosize or submicron particles of silver, platinum with silver and their salts with parabens, oxide, salicylate, acetate, citrate, benzoate and phosphate along with copper and zinc salts of the same.
    Type: Grant
    Filed: November 3, 2008
    Date of Patent: June 5, 2012
    Assignee: ICET, Inc.
    Inventor: Shantha Sarangapani
  • Publication number: 20120009275
    Abstract: A composition comprising a macromer that can be in situ polymerized into a hydrogel wound dressing directly on a wound and one or more antimicrobial agents intended to achieve bacteriostasis and/or be bacteriocidal. The antimicrobial agent is released upon application and trapped in the hydrogel upon its formation and also released over a period of time into the wound.
    Type: Application
    Filed: June 28, 2011
    Publication date: January 12, 2012
    Inventors: Bruktawit T. Asfaw, John C. Jackson, Zhihua Lu, Xiaowen Zhai, Sameer Shums, Thomas Hirt, Xianbo Hu, Claude-Raymond René
  • Patent number: 8092815
    Abstract: Provided are articles containing a solid surface material with an antimicrobial agent in a thermoset and/or thermoplastic resin matrix, wherein the antimicrobial agent comprises a chitosan-metal complex.
    Type: Grant
    Filed: April 22, 2008
    Date of Patent: January 10, 2012
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Subramaniam Sabesan
  • Publication number: 20110171188
    Abstract: The invention relates to a non-thermal plasma for treatment of a surface, particularly for the treatment of a wound (1), wherein the plasma comprises a partially ionized carrier gas and at least one additive, which preferably has a sterilizing effect on the treated surface and/or improves the healing of the wound (1). Further, the invention relates to a corresponding apparatus and method.
    Type: Application
    Filed: August 17, 2009
    Publication date: July 14, 2011
    Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V
    Inventors: Gregor Morfill, Bernd Steffes, Tetsuji Shimizu, Rene Pompl, Tetiana Nosenko, Wilhelm Stolz, Georg Isbary, Hans-Ulrich Schmidt
  • Publication number: 20110159044
    Abstract: The present invention pertains to silver ion bearing carriers useful in treating monorrhagia of a mammalian uterus, comprising a physiologically inert, flexible earner, e.g., a coil, bearing a tissue cauterizing amount of a silver ion. Silver ions are delivered to the endometrium and cause necrosis of the endometrial tissue. The silver ions remaining within the uterine cavity can then be neutralized with a sodium chloride solution delivered to the uterus e.g., by catheter, and the carrier recovered from the uterus.
    Type: Application
    Filed: September 1, 2009
    Publication date: June 30, 2011
    Inventor: Robert S. Neuwirth
  • Publication number: 20110159062
    Abstract: Antiseptic compositions and kits containing a source of silver ions and menthol, which act in synergy such that a concentration of silver ions in the composition is substantially reduced, are disclosed. Further disclosed are uses of the antiseptic compositions as disinfectants and in the treatment of wounds.
    Type: Application
    Filed: March 1, 2011
    Publication date: June 30, 2011
    Inventors: Noa HADAR, Amihay FREEMAN
  • Publication number: 20110104302
    Abstract: An antiviral composition and a method of treating viral conditions comprising colloidal silver, silver nitrate, or both, and an antiviral natural herb or a natural herb from the Rutaceae family, such as Ruta graveolens, Myrtaceae family, such as Melaleuca alternifolia, Cupressaceae family, such as Thuja occidentalis, and the Moraceae family, such as fig, or any combination thereof.
    Type: Application
    Filed: December 14, 2010
    Publication date: May 5, 2011
    Inventor: Iraj E. Kiani
  • Publication number: 20110091557
    Abstract: The invention relates to a composite material, a precursor for forming the composite material and a method of forming the composite material from the precursor. The invention also relates to the use of said composite material and in particular to its use as an antibacterial or antimicrobial agent.
    Type: Application
    Filed: January 14, 2009
    Publication date: April 21, 2011
    Applicant: Smith & Nephew PLC
    Inventors: Joanna Jayne Buckley, Adam Fraser Lee, Karen Wilson
  • Publication number: 20100297200
    Abstract: The present invention is directed to compositions comprising at least one nitric oxide donor and at least one second therapeutically active agent with antimicrobial or wound healing capability. In one embodiment, the nitric oxide donor is a nanoparticle which is designed to control for the amount and duration of release of nitric oxide. The nanoparticle may further comprise the additional therapeutically active agent. The composition is useful for enhancing wound healing and for treating and preventing microbial infection. In one embodiment, the composition is directed toward reducing oral bacteria or dental plaque. The combination of one or more nitric oxide donors and one or more additional therapeutically active agent results in unexpected synergistic effects, wherein both the antimicrobial efficacy of the nitric oxide and the antimicrobial or wound healing efficacy of the second therapeutically active agent are enhanced.
    Type: Application
    Filed: October 10, 2008
    Publication date: November 25, 2010
    Applicant: The University of North Carolina atChapel Hill
    Inventors: Mark A. Schoenfisch, Evan M. Hetrick, Nathan A. Stasko, C. Bryce Johnson
  • Publication number: 20100209535
    Abstract: An antiviral composition and a method of treating viral conditions comprising colloidal silver, silver nitrate, or both, and an antiviral natural herb or a natural herb from the Rutaceae family, such as Ruta graveolens, Myrtaceae family, such as Melaleuca alternifolia, Cupressaceae family, such as Thuja occidentalis, and the Moraceae family, such as unripe fig, or any combination thereof.
    Type: Application
    Filed: August 14, 2009
    Publication date: August 19, 2010
    Inventor: Iraj E. Kiani
  • Publication number: 20100203157
    Abstract: The present invention relates to combinations of pyrimethanil, or a salt thereof, and silver compounds which provide an improved biocidal effect. More particularly, the present invention relates to compositions comprising a combination of pyrimethanil, or a salt thereof, together with one or more silver salts selected from silver acetate, silver alginate, silver azide, silver citrate, silver lactate, silver nitrate, silver sulfate, silver chloride, silver thiocyanate, silver-sodium-hydrogen-zirconium phosphate, silver sulfadiazine, silver cyclohexanediacetic acid and disilver 2,5-dichloro-3,6-dihydroxy-2,5-cyclohexadiene-1,4-dione; in respective proportions to provide a synergistic biocidal effect.
    Type: Application
    Filed: September 5, 2008
    Publication date: August 12, 2010
    Inventors: Dany Leopold Jozefien Bylemans, Jan Pieter Hendrik, Mark Arthur Josepha Van Der Flaas
  • Patent number: 7736423
    Abstract: The present invention relates to an aqueous composition for outdoor, indoor, facade and roof paints having a biocidal action.
    Type: Grant
    Filed: August 23, 2004
    Date of Patent: June 15, 2010
    Assignees: Fraunhofer-Gesellschaft zur Forderung der angewandten Forschung e.V., Bioni CS GmbH
    Inventors: Sven Knoll, Helmut Schmid
  • Patent number: 7700131
    Abstract: Powders having contact biocidal properties comprise a polysaccharide carrying atomic/metallic silver. The preferred polysaccharide is chitin, although other polysaccharides including chitosan, carboxymethyl celluloses and carrageenans can be used. The chitin may be obtained from deproteinated crustacean shells without demineralisation, thus being admixed with calcium carbonate and other naturally occurring minerals present in the shells, and may be enzyme deacetylated. The powders of the invention can be used as biocidal dusting powders, formulated into pastes, gels, hydrogels, creams, foams and aerosol sprays for pharmaceutical applications, or dissolved to form solutions for coating substrates such as skin, fabrics, glass, leather and paper to give a bactericidal surface. A particular application of such a solution is as a protective, post-wash treatment for workwear in a laundering process.
    Type: Grant
    Filed: July 18, 2005
    Date of Patent: April 20, 2010
    Assignee: Chitoproducts Limited
    Inventors: Alan Taylor, George Andrew Francis Roberts, Frances Ann Wood
  • Publication number: 20100034873
    Abstract: Transdermal compositions containing castor oil are described. The compositions comprise ricinoleic acid and a transdermal vehicle with optional additional agents. One optional additional agent is an adrenergic drug which may cause the ricinoleic acid to penetrate the skin more deeply and have a longer lasting effect. The compositions can be used for treating a variety of ailments traditionally treated with castor oil or castor oil packs, without the mess and inconvenience of using castor oil packs.
    Type: Application
    Filed: August 6, 2008
    Publication date: February 11, 2010
    Inventor: Keith Delprete
  • Publication number: 20090312706
    Abstract: Described herein are transdermal delivery devices composed of at least one resealable injection port and at least one local anesthetic reservoir. The device effectively delivers anesthetic to the skin of the subject prior to puncturing the skin by syringes, needle sticks, or other instruments intended to be inserted into the skin. In addition, this device can be used to deliver various therapeutic agents for either locally or systemically.
    Type: Application
    Filed: April 16, 2009
    Publication date: December 17, 2009
    Inventors: Totada Shantha, Jessica Shantha, Erica Shantha, Lauren Shantha
  • Publication number: 20090238850
    Abstract: Materials, compositions, and medical devices for the treatment or prophylaxis of microbial, including bacterial, infections, comprising at least one water-insoluble ceramic compound and at least one metal species. Methods of making such materials, compositions and medical devices.
    Type: Application
    Filed: January 26, 2007
    Publication date: September 24, 2009
    Inventor: Bryan NMI Greener
  • Patent number: 7585460
    Abstract: The invention relates to a method for inhibiting the biological acidification of water which is in contact with materials containing sulfur in reduced form or with elemental sulfur, susceptible to oxidation on the part of Thiobacilli, comprising putting said materials in contact with soluble inorganic salts at concentrations ranging from 0.4 normal to saturation.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: September 8, 2009
    Assignees: ENI S.p.A., Enitecnologie S.p.A.
    Inventors: Francesco Crescenzi, Antonella Crisari, Cesare Achille Piatti
  • Patent number: 7576255
    Abstract: The present invention comprises methods and compositions for making a silver-containing antimicrobial hydrophilic material. More particularly, the present invention comprises methods and compositions for stabilized silver antimicrobial devices comprising a matrix comprising a polymer network and a non-gellable polysaccharide, and an active agent. The matrix may be formed into any desired shape for its desired uses.
    Type: Grant
    Filed: November 1, 2004
    Date of Patent: August 18, 2009
    Assignee: AcryMed, Inc.
    Inventors: Bruce L. Gibbins, Lance D. Hopman
  • Patent number: 7507335
    Abstract: A dendrimer complex comprising a dendrimer and an antimicrobial agent with the dendrimer complex placeable directly into a fluid to inhibit growth of microbes or rid the fluid of microbes. In a further embodiment of the invention the dendrimer complex is secured to a carrier, which is placed in a body of fluid and allowed to dispense the antimicrobial agent into the fluid. Once the antimicrobial agent is dispensed, the dendrimer complex can be removed and recycled to add functional groups to the dendrimer so that the dendrimer can be reused.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: March 24, 2009
    Assignee: KWG Technology
    Inventors: Joseph A. King, John E. Hill
  • Publication number: 20090035342
    Abstract: The present invention comprises methods and compositions for antimicrobial devices comprising metal containing compositions which are resistant to heat and light discoloration. The metal containing compositions may comprise salts or complexes of silver, copper or zinc. In one aspect the compositions comprise silver salts. In another aspect, the compositions comprise silver complexes. In one aspect, the metal salts may comprise metal salts of saccharin, acesulfame, long chain fatty acids, and alkyl dicarboxylic acids. The compositions further comprise polymers which form salts or complexes with silver, copper or zinc. The methods of the present invention comprise treating devices with the metal containing compositions, including, but not limited to, such devices as woven wound care materials, catheters, patient care devices, and collagen matrices. The present invention further comprises treatment of humans and animals with the antimicrobial devices described herein.
    Type: Application
    Filed: August 1, 2005
    Publication date: February 5, 2009
    Inventors: Bhalchandra M. Karandikar, Bruce L. Gibbins, Ken A. Cornell
  • Publication number: 20090017134
    Abstract: A method for controlling fire ants is described, which includes applying a silver-containing composition to an area infested by fire ants or threatened by an infestation. The composition is applied to the area and reduces or eliminates the colony within a period of about two to four weeks and prevents fire ant re-infestation for a period of about six months to one year.
    Type: Application
    Filed: June 20, 2008
    Publication date: January 15, 2009
    Applicant: STB COMPANY
    Inventors: Edward A. Alper, Dennis M. Hoy
  • Patent number: 7470437
    Abstract: Methods of treating conditions with a metal-containing material are disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.
    Type: Grant
    Filed: November 10, 2004
    Date of Patent: December 30, 2008
    Assignee: Nucryst Pharmaceuticals Corp.
    Inventors: Robert E. Burrell, John B. Wright, Kan Lam, Antony G. Naylor, Peter H. Moxham, Scott H. Gillis, Paul Schechter
  • Publication number: 20080286212
    Abstract: Formulations and blends are described comprising zinc, silver, bismuth and copper in non-toxic amounts that are useful as treatments of a wide variety of conditions and diseases promoted by bacteria or other microorganisms.
    Type: Application
    Filed: February 17, 2005
    Publication date: November 20, 2008
    Inventor: Marianna Cooley
  • Patent number: 7445799
    Abstract: An antimicrobial and chemical deactivating composition for use in a liquid medium or for incorporation into a coating, structural plastic materials, thin microporous membranes, textiles and sponges. The composition includes macrosize or submicron particles of silver, platinum with silver and their salts with parabens, oxide, salicylate, acetate, citrate, benzoate and phosphate along with copper and zinc salts of the same.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: November 4, 2008
    Assignee: ICET, Inc.
    Inventors: Shantha Sarangapani, Quoc T. Truong
  • Patent number: 7427416
    Abstract: Methods of treating conditions using metal-containing materials are disclosed. Exemplary conditions include bacterial conditions, biofilm conditions, microbial conditions, inflammatory conditions, fungal conditions, viral conditions, autoimmune conditions, idiopathic conditions, hyperproliferative conditions, noncancerous growths, cancerous conditions and combinations of such conditions. In certain embodiments, the metal-containing material is an atomically disordered, nanocrystalline silver-containing material.
    Type: Grant
    Filed: October 22, 2003
    Date of Patent: September 23, 2008
    Assignee: Nucryst Pharmaceuticals Corp.
    Inventors: Scott H. Gillis, Paul Schechter, James Alexander Robert Stiles
  • Patent number: 7410650
    Abstract: A method of fabricating nano-silver fibers is provided. An organic solution of a dispersant is prepared. Then, a silver salt and a reductant are added into the organic solution. The organic solution is stirred to let the silver salt and the reductant react to form silver nanoparticles dispersed in the organic solution uniformly. Next, a spinnable polymer resin is dissolved in the organic solution to form a spinning solution. A wet spinning method is performed to let the spinning solution form nano-silver fibers.
    Type: Grant
    Filed: January 19, 2006
    Date of Patent: August 12, 2008
    Assignee: Taiwan Textile Research Institute
    Inventor: Jia-Peng Lin
  • Patent number: 7255881
    Abstract: Metal-containing materials, as well as their preparation and use are disclosed. The metal-containing material can be, for example, an antimicrobial material, an anti-biofilm material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, anti-proliferative, MMP modulating material, an atomically disordered, crystalline material, and/or a nanocrystalline material. In certain embodiments, the metal-containing material is an atomically disordered, nanocrystalline silver-containing material.
    Type: Grant
    Filed: October 22, 2003
    Date of Patent: August 14, 2007
    Assignee: Nucryst Pharmaceuticals Corp.
    Inventors: Scott H. Gillis, Paul Schechter, James Alexander Robert Stiles
  • Patent number: 7201925
    Abstract: The treatment of ungual and subungual diseases is disclosed.
    Type: Grant
    Filed: February 2, 2004
    Date of Patent: April 10, 2007
    Assignee: Nueryst Pharmaceuticals Corp.
    Inventor: Scott H. Gillis
  • Patent number: 7147872
    Abstract: Environmentally friendly processes for prevention of qualitative deterioration and quantitative loss of plant matter and foodstuffs, during all stages of storage and handling, including pre- and post-harvest, pre- and post-planting, distribution and marketing involves the use of H2O2 compositions including Ag and at least one of Cu and Zn ions. The processes can also be used to prevent sprouting and rooting, and to promote fecundity of certain plant matter, and can also be used to eliminate or reduce quantities of harmful organisms and substances from soil, other growth media and substrates, equipment, materials water, workspaces and surfaces.
    Type: Grant
    Filed: August 12, 2005
    Date of Patent: December 12, 2006
    Assignee: Pimi Marion Holdings, Ltd.
    Inventors: Nimrod Ben-Yehuda, Eliahu Margalit
  • Patent number: 7125570
    Abstract: An antibacterial composition is provided which comprises a base, an antibacterial agent consisting of a silver-supporting inorganic compound and a water-soluble salt of a nitrogen atom-containing 6-membered heterocyclic compound. In the antibacterial composition, the silver component susceptible to discoloration is effectively stabilized by the use of the water-soluble salt of a nitrogen atom-containing 6-membered heterocyclic compound and therefore, the antibacterial composition never or hardly undergoes any discoloration with the lapse of time.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: October 24, 2006
    Assignee: Sinanen Zeomic Co., Ltd.
    Inventors: Akio Taniguchi, Yasuo Kurihara, Masashi Uchida
  • Patent number: 7097858
    Abstract: Polyoxometalate topical compositions for removing contaminants from an environment and methods of use thereof are disclosed. An embodiment of the polyoxometalate topical composition includes a topical carrier and at least one polyoxometalate, with the proviso that the polyoxometalate is not H5PV2Mo10O40; K5Si(H2O)MnIIIW11O39; K4Si(H2O)MnIVW11O39; or K5CoIIIW12O40. Another embodiment relates to a method for removing a contaminant from an environment, including contacting the polyoxometalate topical composition with the environment containing the contaminant for a sufficient time to remove the contaminant from the environment.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: August 29, 2006
    Assignee: Emory University
    Inventors: Craig L. Hill, Ling Xu, Jeffrey T. Rhule, Eric A. Boring
  • Patent number: 7087249
    Abstract: The invention relates to the use of one or more antimicrobial metals preferably selected from silver, gold, platinum, and palladium but most preferably silver, formed with atomic disorder, and preferably in a nanocrystalline form, for reducing inflammation or infection of the mucosal membrane. The antimicrobial metal may be formulated as, or used in the form of, a nanocrystalline coating of one or more antimicrobial or noble metals, a nanocrystalline powder of one or more antimicrobial or noble metals, or a liquid or solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial or noble metals.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: August 8, 2006
    Assignee: Nucryst Pharmaceuticals Corp.
    Inventors: Robert Edward Burrell, Antony George Naylor, Peter Howard Moxham
  • Patent number: 7078060
    Abstract: Solutions and aerosols of metal-containing compounds are disclosed. Methods of preparing and using the solutions and aerosols, particularly in the treatment of a subject having a condition, are also disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.
    Type: Grant
    Filed: February 12, 2003
    Date of Patent: July 18, 2006
    Assignee: Nucryst Pharmaceuticals Corp.
    Inventors: Robert E. Burrell, John B. Wright, Kan Lam, Hua Qing Yin, Antony G. Naylor, Peter H. Moxham, Scott H. Gillis, Paul Schechter