Heavy Metal Or Compound Thereof Patents (Class 424/617)
  • Patent number: 11920020
    Abstract: A composite material including a nanocellulose core and a metal shell is provided. The metal shell covers a surface of the nanocellulose core. The composite material is nanosized and has high mechanical strength. Additionally, a method of manufacturing the composite material is also provided.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: March 5, 2024
    Assignee: Winbond Electronics Corp.
    Inventors: Ming-Chih Tsai, Yu-Hsuan Ho
  • Patent number: 11892530
    Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.
    Type: Grant
    Filed: August 13, 2020
    Date of Patent: February 6, 2024
    Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.
    Inventors: Yael Mardor, Leor Zach, David Guez, David Last, Dianne Daniels Elmakias
  • Patent number: 11872297
    Abstract: A composition for treating acne includes an anti-acne active agent that includes salicylic acid, an emulsifier, an emollient, particles of zinc oxide, water and a humectant. The composition has a sun protection factor (SPF) of at least 5. The zinc oxide can be included in a powder with particles that are formed as aggregates of smaller particles which, when used in a dispersion at a concentration of 50 weight % of zinc oxide, produces a transparent composition.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: January 16, 2024
    Assignee: Advance Zinctek Limited
    Inventor: Julian Hewitt
  • Patent number: 11866610
    Abstract: A tablet-based method for fabricating a suspension including gold (Au) particles and water can include adding to water a solid tablet prepared from a solid alkaline powder, a solid acid powder, and gold particles. Carbon dioxide (CO2) gas can be generated once the tablet is added to the water. The gold (Au) particles can be in microparticle or nanoparticle form. The solid alkaline powder can include sodium bicarbonate (NaHCO3) or sodium carbonate (Na2CO3). The solid acid powder can include monosodium phosphate (NaH2PO4).
    Type: Grant
    Filed: January 31, 2022
    Date of Patent: January 9, 2024
    Assignee: KUWAIT INSTITUTE FOR SCIENTIFIC RESEARCH
    Inventors: Naser Alsayegh, Husain Bahzad, Nawaf F. Aljuwahel
  • Patent number: 11833232
    Abstract: A deodorant stick comprising: a natural or naturally-derived oil; an antimicrobial; a naturally-derived wax blend comprising from about 5% to about 20% an ester wax having a melting point of at least about 55° C.; and from 0.01% to 2% a fatty alcohol or fatty alcohol-containing wax; wherein the deodorant stick is anhydrous and substantially free of aluminum; and wherein the stick has an oil binding capacity percent of at least 80%.
    Type: Grant
    Filed: August 24, 2021
    Date of Patent: December 5, 2023
    Assignee: The Procter & Gamble Company
    Inventors: David Arthur Sturgis, Lindsey Michelle Britt, Mahmoud Daffalla Eljack
  • Patent number: 11793784
    Abstract: The present application relates to compounded compositions, methods of making compounded compositions, and methods of using compounded compositions. For example, disclosed herein are compounded compositions and methods of making compounded compositions comprising one or more anti-infective agents such as mupirocin.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: October 24, 2023
    Assignee: CMPD Licensing, LLC
    Inventor: Jay Richard Ray, II
  • Patent number: 11752296
    Abstract: A self-cleaning cannula for placement in a patient, including an elongated tube portion having an inner surface and an oppositely disposed outer surface, a first end fluidically connectable to a fluid source outside the patient and a second, oppositely disposed end for fluidically communicating with the patient, and a plurality of magnetic nanoparticles operationally connected to at least a portion of the cannula. The metallic nanoparticles may be energized by an applied oscillating magnetic field to heat the cannula.
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: September 12, 2023
    Inventor: Hyowon Lee
  • Patent number: 11717493
    Abstract: The present invention includes composition and methods for treating inflammation and/or pain, the composition comprising: hemp cannabidiol (cannabinoid) 0.1%-0.6% weight percent; menthol 3.0-4.0% weight percent; arnica montana 0.1-5.0% weight percent; camphor 0.1-5.0% weight percent; bosweila serrata extract 0.1-5.0% weight percent; camphor terpene 0.1-5.0% weight percent; isopropyl alcohol <30% weight percent; glycerin <6.0% weight percent; and qs with water.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: August 8, 2023
    Assignee: RevRx, LLC
    Inventor: Aaron Michael Schneider
  • Patent number: 11696896
    Abstract: Provided herein are immunomodulatory nanoparticles, compositions containing the same, and methods of use thereof, such as for the treatment of traumatic brain injury.
    Type: Grant
    Filed: October 21, 2020
    Date of Patent: July 11, 2023
    Assignee: Northwestern University
    Inventors: John A. Kessler, Sripadh B. Sharma
  • Patent number: 11649633
    Abstract: Roofing systems are disclosed herein. In particular, a method of making an asphaltic roofing product having an asphaltic substrate and at least one granule disposed thereon is disclosed herein.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: May 16, 2023
    Assignee: U.S. Silica Company
    Inventors: Steve Canova, Chad Cannan
  • Patent number: 11607467
    Abstract: A method of forming metal nanoparticles includes applying a substance to an area of interest, applying cold plasma to the area of interest, and synthesizing nanoparticles from the substance using the cold plasma in the area of interest, wherein the substance is a solution that contains metal ions, and the nanoparticles synthesized are metallic in nature.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: March 21, 2023
    Assignee: PLASMOLOGY4, INC.
    Inventor: Emilia M. Kulaga
  • Patent number: 11382930
    Abstract: The invention relates to the treatment of different bone injuries, particularly fractures and fissure fractures. In order to reduce the time taken for bone tissue to regenerate at the site of damage, a method is used for regenerating bone tissue by fixing fragments of the damaged bone with a plaster cast or a bandage made of a polymer material and introducing into the fracture zone an aqueous solution containing 1-hydroxyethylidene diphosphonic acid in an amount of (1.80-2.06) g/l, anhydrous calcium chloride in an amount of (1.44-2.22) g/l, gadolinium (III) nitrate hexahydrate in an amount of (0.30-0.40) g/l and dysprosium (III) chloride hexahydrate in an amount of (0.038-0.076) g/l, with a pH of (7.3-7.8), wherein, prior to being introduced into the fracture zone, the above solution is brought to a temperature of (30-100°) C., is held at this temperature for (1-48) hours and is then cooled to room temperature.
    Type: Grant
    Filed: November 23, 2020
    Date of Patent: July 12, 2022
    Assignee: OOO “FELIX”
    Inventor: Fedor Vladimirovich Devyatov
  • Patent number: 11369633
    Abstract: The present disclosure relates to mesoporous glasses as well as uses of such glasses, for example, as hemostats.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: June 28, 2022
    Inventor: Mark Towler
  • Patent number: 11298423
    Abstract: Compositions are provided herein comprising a coacervate of a polycationic polymer, a polyanionic polymer, and platelet-rich plasma and/or serum, or a fraction or concentrate thereof. The composition is useful in wound healing. Compositions also are provided that comprise a hydrogel comprising TIMP-3; and a complex of a polycationic polymer, a polyanionic polymer, FGF-2 and SDF-1? embedded in the hydrogel, which is useful in treating a myocardial infarction.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: April 12, 2022
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Eric M. Jeffries, Noah R. Johnson, Daniel Long, Yadong Wang
  • Patent number: 11266678
    Abstract: The present invention relates to a composition for articular cavity injection comprising a nucleic acid and chitosan. More specifically, in the present invention, it was confirmed that the sol-gel transition occurred depending on the temperature in the composition for articular cavity injection prepared through the mixing of the nucleic acid and chitosan, the proteoglycan biosynthesis of the cartilage tissue was increased by the injection of the composition and the cartilage regeneration effect was exhibited, and the pain was alleviated and the walking speed and stride which are the joint motilities were improved. Therefore, development of a therapeutic agent for arthritis having an excellent therapeutic effect using the composition for articular cavity injection comprising the nucleic acid and chitosan of the present invention is expected.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: March 8, 2022
    Assignee: PHARMARESEARCH CO., LTD.
    Inventors: Ik Soo Kim, Han Gyu Kim, Su Yeon Lee
  • Patent number: 11259989
    Abstract: Energy stimulated acupuncture, directed to a novel set of acupoints, is implemented to treat hypertension. The disclosed methods and systems are directed toward the application of electrical stimulation, or other forms of energy, to specific acupuncture points, using devices such as transcutaneous electrical stimulation electroacupuncture devices, laser acupuncture devices or ultrasound acupuncture devices, to treat hypertension, particularly in middle-aged women.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: March 1, 2022
    Inventor: Shaista Malik
  • Patent number: 11224633
    Abstract: Disclosed is a kit including a first container including a composition including at least one antioxidant selenoprotein and at least one second container including at least one composition including at least one oxidant selenocompound. Also disclosed is a method of administration that allows to administer effective and cytotoxic doses of selenocompounds, allowing the inhibition of the hyper-activation of phagocytes and in particular of circulating immature neutrophils and directly and indirectly protects endothelial cells, in particular for the treatment of sepsis, SIRS and leukemia. Further disclosed is an administration device adapted to the administration method.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: January 18, 2022
    Assignee: SERENITE-FORCEVILLE
    Inventor: Vincent Cotereau
  • Patent number: 11208628
    Abstract: In one aspect, a composition can include an organelle, and a nanoparticle having a zeta potential of less than ?10 mV or greater than 10 mV contained within the organelle. In a preferred embodiment, the organelle can be a chloroplast and the nanoparticle can be a single-walled carbon nanotube associated with a strongly anionic or strongly cationic polymer.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: December 28, 2021
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Michael S. Strano, Juan Pablo Giraldo Gomez, Sean Mitchell Faltermeier, Markita P. Landry
  • Patent number: 11207346
    Abstract: Aqueous compositions and methods using the compositions for preventing or minimizing live body weight loss in livestock animals subjected to a prolonged period of feed deprivation, e.g., such as during the period before slaughter or during a period surrounding transportation from one location to another location (e.g., before, during and/or after), and/or for minimizing carcass weight loss or carcass yield loss, and/or meat quality deterioration and/or for preventing or minimizing deterioration of the well-being or health of livestock animals subjected to a prolonged period of feed deprivation, e.g., such as during the period before slaughter or during a period surrounding transportation from one location to another location (e.g., before, during and/or after).
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: December 28, 2021
    Assignee: Nutreco Nederland B.V.
    Inventors: Javier Martin-Tereso Lopez, Isabela Pena Carvalho De Carvalho
  • Patent number: 11140901
    Abstract: A synergistic aqueous wood preservative composition comprising a copper compound and penflufen. The copper compounds of the compositions of the invention may be soluble, partially solubilized or micronized particles. The penflufen of the compositions of the invention may be solubilized, emulsified or particulate. The wood preservative compositions of the present invention are surprisingly provided as stable dispersions and confer surprising and unexpected resistance to treated wood and wood products.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: October 12, 2021
    Assignee: KOPPERS PERFORMANCE CHEMICALS INC.
    Inventors: Jun Zhang, Peter Tham, John Horton
  • Patent number: 11123363
    Abstract: The present invention generally relates to methods of treating hypertension (HTN) in patients in need thereof wherein the patient optionally further suffers from chronic kidney disease (CKD) or Type II diabetes mellitus (T2DM). The invention also relates to methods of treating hyperkalemia in a patient in need thereof, wherein the patient suffers from CKD, T2DM or HTN and are optionally being treated with an effective amount of a renin-angiotensin-aldosterone system (RAAS) agent. The invention also relates to methods of treating kidney disease in a patient in need thereof, wherein the patient is optionally being treated with an effective amount of a renin-angiotensin-aldosterone system (RAAS) agent. The methods can comprise administering an effective amount of a potassium-binding agent to the patient to lower the patient's blood pressure and/or increase or stabilize the patient's kidney function.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: September 21, 2021
    Assignee: VIFOR (INTERNATIONAL) LTD.
    Inventors: Gerrit Klaerner, Lance Berman
  • Patent number: 11000510
    Abstract: Provided herein are methods of treating B-cell proliferative disorders in particular Follicular Lymphoma and/or Diffuse Large B-Cell Lymphoma using immunoconjugates comprising anti-CD79b antibodies in combination with additional therapeutic agents.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: May 11, 2021
    Assignee: Genentech, Inc.
    Inventors: Andrew Polson, Shang-Fan Yu, Yu-Waye Chu, Michael Wenger, Jamie Harue Hirata, Dan Lu
  • Patent number: 10925282
    Abstract: A process is provided for the time dependent reduction and kill of cellular bacteria in a fluid by sequential exposure to nitrites and a low concentration of biocide. Oilfield water containing sulfate-reducing bacteria can be supplied with a timed sequential exposure of nitrite and biocide. The timed sequential addition of the biocide following exposure to the nitrite provides enhanced kill of the sulfate-reducing bacteria at concentrations of biocide that are lower than would be possible using simultaneous addition of these materials.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: February 23, 2021
    Assignee: CONOCOPHILLIPS COMPANY
    Inventor: Gary Jenneman
  • Patent number: 10835640
    Abstract: The invention relates to resorbable crosslinked form stable membrane which comprises a composite layer of collagen material and inorganic ceramic particles containing 1.5 to 3.5 weight parts of inorganic ceramic for 1 weight part of collagen material, sandwiched between two layers of elastic pretensed collagen material (collagen material that has been stretched such as to be in the linear/elastic region of the stress-strain curve), the collagen material comprising 50-100% (w/w) collagen and 0-50% (w/w) elastin, and has shape and dimensions suitable for use in human tissue regeneration outside the oral cavity in rhinoplasty, postlateral spinal fusion or orbital reconstruction.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: November 17, 2020
    Assignee: Geistlich Pharma AG
    Inventors: Niklaus Stiefel, Sergej Stenzel, Raphael Kaufmann
  • Patent number: 10809323
    Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: October 20, 2020
    Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., Remot at Tel-Aviv University Ltd.
    Inventors: Yael Mardor, Leor Zach, David Guez, David Last, Dianne Daniels
  • Patent number: 10800990
    Abstract: A multifunctional comprehensive mineral supplement including molecular clusters, wherein at least a portion of the molecular clusters each has a metal core and one or more ligands attached to the metal core, wherein at least a portion of the metal core and/or one or more ligands is provided by or derived from a mineral component.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: October 13, 2020
    Assignee: DIMTOV CORP
    Inventors: Stepan Minasov, Sharon Gililov
  • Patent number: 10765777
    Abstract: This disclosure relates compositions comprising upconverting core-shell nanocrystals and photoactive compositions and methods using these compositions to modify treat myopia and other ocular conditions. In some cases, the methods use near infrared irradiation to adjust the refractive power of light adjustable intraocular lenses.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: September 8, 2020
    Assignee: California Institute of Technology
    Inventors: Robert H. Grubbs, Christopher B. Marotta
  • Patent number: 10675292
    Abstract: The invention pertains to the use of one or more of uridine and cytidine, or salts, phosphates, acyl derivatives or esters thereof in the manufacture of a composition for treating, preventing or reducing the risk of occurrence of white matter lesions, white matter hyperintensities (WMH), Leukoaraiosis or periventricular white matter disease in elderly not suffering from a neurodegenerative disorder, preferably non-demented elderly and elderly not suffering from Alzheimer's Disease. It was found that with the compositions according to the invention Nogo-A protein levels could be controlled, particularly suppressed or reduced.
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: June 9, 2020
    Assignee: N.V. NUTRICIA
    Inventors: Nick Van Wijk, Robert Johan Joseph Hageman, Mehmet Cansev
  • Patent number: 10653718
    Abstract: The invention relates to a specific composition for oral administration of magnesium, for use in the treatment of type 2 diabetes or the complications thereof, in association with a composition for treating type 2 diabetes or the complications thereof.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: May 19, 2020
    Inventor: Fabienne Joanny Menvielle-Bourg
  • Patent number: 10613180
    Abstract: A method of assessing tissue vascular permeability for nanotherapeutics using non-labeled dextran can include: receiving a non-labeled, physiologically-tolerable dextran solution by a subject; acquiring a plurality of magnetic resonance images of a distribution of the dextran solution within at least one region of interest of the subject for a corresponding plurality of times; and assessing a tissue vascular permeability of the at least one region of interest to dextran particles in the dextran solution based on differences between the plurality of magnetic resonance images, wherein the dextran solution is a substantially mono-disperse solution of dextran particles of one size.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: April 7, 2020
    Assignees: The Johns Hopkins University, Kennedy Krieger Institute
    Inventors: Guanshu Liu, Peter C. M. Van Zijl, Yuguo Li
  • Patent number: 10604827
    Abstract: The invention relates to biodegradable, metal alloy-containing compositions, methods for their preparation and applications for their use. The compositions include magnesium and other components, such as yttrium, calcium, silver, cerium, and zirconium; or zinc, silver, cerium, and zirconium; or aluminum, zinc, calcium, manganese, silver, yttrium; or strontium, calcium, zinc. The compositions are prepared by vacuum induction/crucible melting together the components and casting the melted mixture in a preheated mild steel/copper mold. In certain embodiments, the compositions of the invention are particularly useful for forming medical devices for implantation into a body of a patient.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: March 31, 2020
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Educatiion
    Inventors: Prashant N. Kumta, Da-Tren Chou, Daeho Hong, Partha Saha
  • Patent number: 10602761
    Abstract: A composition for improving meat product quality, comprising at least 4-30 of an edible salt, 1-15 of a carbonate, 0.1-15 of an organic acid salt, 0.1-6 of a sugar alcohol, 0.1-8 of an isomaltulose and/or trehalose, and 0.01-8 of a chito-oligosaccharide composition, in weight parts. The composition has good water retention and good meat tenderizing effect, in addition to be still a good meat tenderizer after repeated freezing and cooking with the meat product being highly elastic, tender and juicy and having little loss during freezing and cooking.
    Type: Grant
    Filed: June 25, 2016
    Date of Patent: March 31, 2020
    Inventor: Kai Jiang
  • Patent number: 10583116
    Abstract: Methods of preventing and/or treating bacterial vaginosis are provided. The methods involve administration of cholesterol lowering drugs in combination with agents that reduce cholesterol absorption, and compositions for performing the methods.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: March 10, 2020
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Kimberly K. Jefferson, Abdallah A. Abdelmaksoud, Philippe H. Girerd, Gregory Buck
  • Patent number: 10478454
    Abstract: The invention discloses aluminium oxyhydroxide for use in the treatment and prevention of AD.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: November 19, 2019
    Assignee: AFFIRIS AG
    Inventors: Markus Mandler, Achim Schneeberger, Arne Von Bonin, Frank Mattner, Walter Schmidt
  • Patent number: 10463657
    Abstract: A method for treating osteoporosis and related methods are disclosed. The methods generally comprise administering to a patient in need of treatment an effective amount of tris(8-quinolinolato)gallium(III) or an analog thereof.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: November 5, 2019
    Assignee: Altum Pharmaceuticals Inc.
    Inventor: Hooshmand Sheshbaradaran
  • Patent number: 10449691
    Abstract: Methods for treating cellulosic materials comprising introducing a liquid treating composition into the cellulosic material, the treating composition comprising a solution prepared from at least: (i) one or more of a copper amine complex or copper ammine complex, such as copper tetraamine carbonate, (ii) one or more of ammonia or a water-soluble amine and (iii) water; and exposing the cellulosic material provided thereby to carbon dioxide and/or carbonic acid to provide treated cellulosic material, and treated cellulosic materials prepared thereby.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: October 22, 2019
    Assignee: American Chemet Corporation
    Inventor: Daniel Brimhall
  • Patent number: 10245025
    Abstract: A packaged antimicrobial suture. The packaged antimicrobial suture includes an inner package having a source of antimicrobial agent, the source of antimicrobial agent comprising a plurality of patches, each patch having a pair of antimicrobial material reservoirs; at least one suture positioned within the inner package, the at least one suture comprising one or more surfaces; and an outer package having an inner surface, the outer package having the inner package positioned within; wherein the at least one suture, the inner package and the inner surface of the outer package are subjected to time, temperature and pressure conditions sufficient to transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the at least one suture and the inner package, thereby substantially inhibiting bacterial colonization on the at least one suture and the inner package. A method of making a packaged antimicrobial suture having is also provided.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: April 2, 2019
    Assignee: Ethicon, Inc.
    Inventors: Michael David Prikril, Howard L. Scalzo, Jr., Leon Gisin
  • Patent number: 10174457
    Abstract: A nanocomposite material with antimicrobial properties, based on cellulose packed with a mineral filler (zeolite) exchanged with silver, characterised in that the mineral filler is made up of Y-type zeolites, while silver occurs in a form bound with the zeolite matrix in the form of cations and, optionally, nanoparticles of reduced silver, as well as a method for preparation of such a material and its application for the wrapping of plants, works of art, archives and antique objects, as well as food, pharmaceuticals and animal fodder.
    Type: Grant
    Filed: May 9, 2015
    Date of Patent: January 8, 2019
    Assignees: Uniwersytet Jagiellonski, Instytut Inzynierii Chemicznej Pan
    Inventors: Joanna Lojewska, Tomasz Lojewski, Jacob L. Thomas, Roman J. Jedrzejczyk, Dominika Pawcenis, Barbara Gil, Jakub M. Milczarek, Katarzyna Turnau, Andrzej Kolodziej
  • Patent number: 10137164
    Abstract: This document provides dietary supplement compositions. For example, dietary supplement compositions having an acetylcholinesterase inhibitor (e.g., huperzine A), a Bacopa monnieri extract, acetyl-L-carnitine or acetyl CoA, and a curcuminoid (e.g., curcumin) are provided.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: November 27, 2018
    Assignee: Melaleuca, Inc.
    Inventors: Alexander B. Rabovsky, Stephanie Y. Nielson
  • Patent number: 10111970
    Abstract: Ascorbate or a pharmaceutically acceptable salt thereof is described for use in carrying out a method, or for the preparation of a medicament for carrying out a method, of enhancing a magnetic resonance imaging (MRI) image of a body or body region such as an organ or organ region in a subject. The method is carried out by parenterally administering ascorbate or a pharmaceutically acceptable salt thereof to the subject in an MRI image-enhancing amount; and then generating, by MRI of the subject, an image of the body or body region. The ascorbate or pharmaceutically acceptable salt thereof enhances the MRI image.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: October 30, 2018
    Assignee: Duke University
    Inventor: Christopher David Lascola
  • Patent number: 10098921
    Abstract: An anti-gout composition including the mixed extract of Chrysanthemum indicum and Cinnamomum cassia as an active ingredient shows substantially greater inhibitory effects on xanthine oxidase than when Chrysanthemum indicum or Cinnamomum cassia is used separately. An animal model treated with the mixed extract of Chrysanthemum indicum and Cinnamomum cassia experienced a decrease in uric acid in serum and in urine. The mixed extract of Chrysanthemum indicum and Cinnamomum cassia is an active ingredient induced from a natural material, and, accordingly, the mixed extract is safe and a source material therefor is easily provided. Accordingly, the mixed extract can be widely used in gout-related industries.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: October 16, 2018
    Assignee: KOREA INSTITUTE OF ORIENTAL MEDICINE
    Inventor: Dong Seon Kim
  • Patent number: 9980895
    Abstract: The present invention relates to an emulsion-type cosmetic composition for coating keratin fibers, comprising: —an aqueous phase, —particles comprising at least one hard wax, preferentially in the form of an aqueous dispersion, having a melting point greater than or equal to 60° C., the hard wax(es) being present at a total content greater than or equal to 10% by weight relative to the total weight of the composition, —at least one emulsifying system capable of dispersing at least the hard wax(es), comprising a non-ionic surfactant with an HLB value at 25° C. greater than or equal to 8, preferably greater than or equal to 10, and —at least one particular anionic associative polymer. The present invention also relates to a method for coating keratin fibers, to a method for preparing a cosmetic composition for coating keratin fibers, to a cosmetic composition for coating keratin fibers which is obtained by means of said production method, and also to a particular use.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: May 29, 2018
    Assignee: L'OREAL
    Inventors: Philippe Ilekti, Maitena Leuridan, Chrystel Michallet-Geoffroy
  • Patent number: 9895467
    Abstract: This disclosure relates compositions comprising upconverting nanocrystals and photoactive compositions and methods using these compositions to modify treat myopia and other ocular conditions. In some cases, the methods use near infrared irradiation to adjust the refractive power of light adjustable ocular lenses. Other methods improve the mechanical strength of the sclera directly.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: February 20, 2018
    Assignee: California Institute of Technology
    Inventors: Robert H. Grubbs, Shane L. Mangold
  • Patent number: 9772388
    Abstract: A probe unit (100) including a magnet (102, 103) generates a static magnetic B0 field in an examination region and a RF coil (105). An input-output module (201) includes a transmitter (203) which controls the RF coil (105) to excite resonance and cause echoes (210) and a receiver (204) which demodulates and digitizes the echoes (210). A data processing module (206) includes at least one processor programmed to calculate a T2 relaxation distribution plot from a digitized echo (210) train, calculate a first area under the fat peak on the T2 distribution plot, calculate a second area under a water peak on the T2 distribution plot, and normalize the first and second area to determine a fat-to-water ratio.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: September 26, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Thomas Perkins
  • Patent number: 9700630
    Abstract: The present invention relates to a parenteral drug delivery carrier and a drug delivery system that use a thermosensitive gel based on methyl cellulose alone as a low molecular weight polysaccharide without a salting-out salt. The single use of the low molecular weight methyl cellulose as a natural polymer increases the biocompatibility and biodegradability of the drug delivery system. Therefore, the drug delivery system is suitable for use in the preparation of a sustained release composition for parenteral drug delivery.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: July 11, 2017
    Assignee: INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY
    Inventors: Yong-Hee Kim, Jang Kyoung Kim
  • Patent number: 9688653
    Abstract: This invention relates generally to the discovery of a method of inhibiting, preventing or treating bacterial infections. The invention also relates to a method of inhibiting bacterial capsule biogenesis.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: June 27, 2017
    Assignees: Duke University, University of Kansas, Southern Research Institute
    Inventors: Patrick C. Seed, Carlos C. Goller, Steven Rogers, Brooks Maki, Frank Schoenen, James Noah, E. Lucile White
  • Patent number: 9649337
    Abstract: A method of treating or preventing neurological injury in a subject who has suffered a stroke is described. The method includes administering a therapeutically effective amount of cerium oxide nanoparticles to the subject. Methods for prophylaxis against neurological injury from stroke, and methods for treating or preventing cardiovascular disease by administration of a therapeutically effective amount of cerium oxide nanoparticles are also described.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: May 16, 2017
    Assignee: EDWARD VIA VIRGINIA COLLEGE OF OSTEOPATHIC MEDICINE
    Inventors: Beverly A. Rzigalinski, Kevin Hockey, Landon M. Klein, Christopher A. Sholar, Justin Himler, Marc J. Billings, Jayce Cook
  • Patent number: 9517188
    Abstract: Disclosed are water-based cosmetic compositions comprising a synthetic non-associative thickening polymer, a synthetic associative thickening polymer, an emulsifier, a film forming polymer, and a liquid fatty substance. The ratio of the synthetic non-associative thickening polymer to the synthetic associative thickening polymer is greater than 1:1, or alternatively, said ratio is less than or equal to 1:1.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: December 13, 2016
    Assignee: L'OREAL
    Inventors: Christine Marie Crane, Angeles Fonolla-Moreno
  • Patent number: 9446150
    Abstract: The invention encompasses particles comprising metal atoms, methods of making the particles, and methods for using the particles. In particular, the particles may be used to image biological tissues or to deliver a bioactive agent.
    Type: Grant
    Filed: October 9, 2008
    Date of Patent: September 20, 2016
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Gregory M. Lanza, Samuel A. Wickline, Dipanjan Pan, Angana Senpan
  • Patent number: 9370190
    Abstract: A new composition for repelling pests is disclosed, wherein said composition comprises an extract produced from at least one plant chosen from the group consisting of Achillea spp., Varthemia iphionoides, Haplophyllum turberculatum, Pulicaria incisa, Asteriscus graveolens, Tanacetum sinaicum, Verbascum spp., Artemisia spp., and Ammi visnaga. In preferred embodiments, the extract is produced from Achillea spp. Methods for applying the composition are also disclosed. The composition has been shown to be effective against a variety of pests, including aphids, thrips, tomato borers, tomato leaf miners, and whiteflies.
    Type: Grant
    Filed: July 4, 2013
    Date of Patent: June 21, 2016
    Assignee: EDEN SHIELD LTD.
    Inventors: Yaniv Kitron Kuperstein, Yonatan Eitan Menashe