Mercury Patents (Class 424/644)
  • Patent number: 10159256
    Abstract: The disclosure describes a composition for use in treating wounds in trees, plants and vines. In addition, the disclosure provides a method of making the compositions and their use in treating fungal infections of pruning wounds.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: December 25, 2018
    Assignee: The Regents of the University of California
    Inventor: Philippe Rolshausen
  • Patent number: 8895075
    Abstract: A herbomineral composition for the treatment of sickle cell disease is described in the present invention. The herbo mineral composition include some herbal ingredients such as Jaiphal, Sunthi, Jivanti, Haritaki, Guduchi, Shatavari, Dadima, Pippali, along with the therapeutic minerals such as Abrakha Bhasma and Loha Bhasma at suitable concentrations to obtain synergistic anti sickling activity. The composition exhibited up to 60-87% antisickling activity on RBCs in ‘vitro’ at various concentrations. Patients treated with this composition found relief from most of the severe symptoms of sickle cell disease and sickle cell anemia, and had excellent improvement in quality of life.
    Type: Grant
    Filed: September 16, 2008
    Date of Patent: November 25, 2014
    Inventor: Atul M. Desai
  • Publication number: 20130344083
    Abstract: Provided are methods and compositions for treatment of cancer. In particular, these methods and compositions may include an inhibitor of a deubiquitinating enzyme. In certain aspects, these methods and compositions may include a modulator of glucose metabolism. Also provided are methods of assaying the glucose content of cells and tissues using detection of uH2B.
    Type: Application
    Filed: March 14, 2013
    Publication date: December 26, 2013
    Inventors: C. Wilson Xu, Yasuyo Urasaki
  • Publication number: 20130287791
    Abstract: Provided are methods and compositions for treatment of cancer. In particular, these methods and compositions may include an inhibitor of a deubiquitinating enzyme. In certain aspects, these methods and compositions may include a modulator of glucose metabolism. Also provided are methods of assaying the glucose content of cells and tissues using detection of uH2B.
    Type: Application
    Filed: March 13, 2013
    Publication date: October 31, 2013
    Inventor: C. Wilson Xu
  • Publication number: 20130216574
    Abstract: The present invention discloses a unique kit for providing a combinational therapeutic product comprising a medical device and a pharmaceutical composition to treat mammal diseases. The medical device is to meet these unmet needs of cleansing out these harmful substances, such as viruses, multiple drug resistant bacteria, fungi, pollen, dusts, or excessive mucus. The pharmaceutical composition adds the required functions of anti-inflammatory, anti-allergy, anti-cancer, promoting membrane healing or immunomodulating, to have the added effect of the medical device. The method of using the combinational product is also disclosed. The new product can be used to prevent and treat a variety of diseases, such as common cold, drug resistant influenza, sinusitis, post nasal drip, virus-triggered asthma, or chronic obstructive pulmonary disease. In addition, the new kit and the process of use are safe and cost effective.
    Type: Application
    Filed: February 20, 2012
    Publication date: August 22, 2013
    Inventor: James Liu
  • Publication number: 20130039953
    Abstract: A method for treating a surface with a therapeutic agent is disclosed. The method comprises precipitating a therapeutic agent from a hydrophilic polymeric base layer with which the therapeutic agent has been complexed, to form a layer comprising microparticles of the therapeutic agent on the hydrophilic polymeric base layer, the hydrophilic polymeric base layer being grafted to the surface. Devices comprising a surface having a hydrophilic polymeric base layer comprising a hydrophilic polymer grafted to the surface and a layer comprising microparticles of a therapeutic agent disposed on and complexed with the hydrophilic polymeric base layer are also disclosed.
    Type: Application
    Filed: July 6, 2012
    Publication date: February 14, 2013
    Applicant: Covalon Technologies
    Inventors: Vyacheslav Dudnyk, Valerio DiTizio
  • Publication number: 20120301409
    Abstract: A homeopathic composition and method for treating a variety of skin irritations, wounds, and diseases is disclosed. The homeopathic composition may contain as active ingredients salicyclic acid, trona or one of its salts, and at least one homeopathic agent.
    Type: Application
    Filed: May 23, 2011
    Publication date: November 29, 2012
    Inventors: Ned L. Jensen, Peter E. Fuller
  • Publication number: 20120195974
    Abstract: The invention disclosed in this document concerns controlling mealybugs.
    Type: Application
    Filed: January 27, 2012
    Publication date: August 2, 2012
    Applicant: DOW AGROSCIENCES LLC
    Inventors: Mayank Yadav, Suresh Ramachandran, Sanjoy Kundu
  • Publication number: 20120177725
    Abstract: The present invention relates to liposomal pharmaceutical preparations which include active agents such as antiseptic agents, wound-healing agents, or combinations thereof, useful in the treatment of external wounds. The active agents are encapsulated in liposomes, and the liposomes are incorporated in pharmaceutical preparations such as liquids, ointments, gels, lotions, or creams capable of delivering the active agents to external wound sites. The invention further relates to methods of preparation of the liposomes and the pharmaceutical preparations, and to methods of treatment of external wounds and ophthalmic infections.
    Type: Application
    Filed: March 9, 2012
    Publication date: July 12, 2012
    Inventors: Dieter Ruckert, Hermann Gumbel, Wolfgang Fleischer, Karen Reimer, Horst Winkler
  • Publication number: 20120171276
    Abstract: A virus inactivating sheet is provided that can inactivate viruses adhering thereto even in the presence of lipids and proteins regardless of whether or not the viruses have an envelope. The virus inactivating sheet can inactivate viruses adhering thereto and includes a sheet body, and monovalent copper compound fine particles and/or iodide fine particles that are held by the sheet body. The virus inactivating sheet can inactivate various viruses. These viruses can be inactivated even in the presence of lipids and proteins.
    Type: Application
    Filed: October 4, 2010
    Publication date: July 5, 2012
    Inventors: Yoshie Fujimori, Youhei Jikihara, Tetsuya Sato, Yoko Fukui, Tsuruo Nakayama
  • Publication number: 20120009253
    Abstract: Use of an anti-inflammatory agent such as povidone iodine for the preparation of a pharmaceutical composition for the treatment of diseases of the lower respiratory tract which are susceptible to the administration of such agents.
    Type: Application
    Filed: September 22, 2011
    Publication date: January 12, 2012
    Inventors: Wolfgang Fleischer, Karen Reimer
  • Patent number: 8007832
    Abstract: A composition and method for treating mammals suffering from malignant tumors which involves administering a composition including ammoniated mercury, zinc oxide and citric acid.
    Type: Grant
    Filed: August 16, 2006
    Date of Patent: August 30, 2011
    Inventors: Yousef Haik Babikian, Walid Adib Taybeh
  • Patent number: 7875182
    Abstract: Size-selective hemocompatible porous polymeric adsorbents are provided with a pore structure capable of excluding molecules larger than 50,000 Daltons, but with a pore system that allows good ingress and egress of molecules smaller than 35,000 Daltons. The pore system in these porous polymeric adsorbents is controlled by the method of synthesis so that 98% of the total pore volume is located in pores smaller than 300 Angstroms (?) in diameter with a working pore size range within 100 to 300 ? in diameter. The porous polymeric adsorbents of this invention are very selective for extracting midsize proteins, such as cytokines and ?2-microglobulin, from blood and other physiologic fluids while keeping the components required for good health such as cells, platelets, albumin, hemoglobin, fibrinogen, and other serum proteins intact.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: January 25, 2011
    Assignee: Cytosorbents, Inc.
    Inventors: Wei-Tai Young, Robert L. Albright, Thomas D. Golobish
  • Publication number: 20100189806
    Abstract: Methods of growing and harvesting multiple species of phytoplankton are disclosed herein. The method generally includes four steps, namely: (1) collecting phytoplankton seawater containing multiple species of naturally-occurring phytoplankton directly from a source of seawater; (2) adding nutrients to the phytoplankton seawater to proliferate the multiple species of naturally-occurring phytoplankton to a predetermined density; (3) separating the multiple species of naturally-occurring phytoplankton from the phytoplankton seawater to form a phytoplankton concentrate; and (4) collecting the phytoplankton concentrate such that the collected phytoplankton of the phytoplankton concentrate remain in a substantially intact cellular state.
    Type: Application
    Filed: October 21, 2009
    Publication date: July 29, 2010
    Inventors: Margaret Harper, Arturo Ramirez
  • Publication number: 20100189814
    Abstract: A herbomineral composition for the treatment of sickle cell disease is described in the present invention. The herbo mineral composition include some herbal ingredients such as Jaiphal, Sunthi, Jivanti, Haritaki, Guduchi, Shatavari, Dadima, Pippali, along with the therapeutic minerals such as Abrakha Bhasma and Loha Bhasma at suitable concentrations to obtain synergistic anti sickling activity. The composition exhibited up to 60-87% antisickling activity on RBCs in ‘vitro’ at various concentrations. Patients treated with this composition found relief from most of the severe symptoms of sickle cell disease and sickle cell anemia, and had excellent improvement in quality of life.
    Type: Application
    Filed: September 16, 2008
    Publication date: July 29, 2010
    Inventor: Atul M. Desai
  • Publication number: 20090312706
    Abstract: Described herein are transdermal delivery devices composed of at least one resealable injection port and at least one local anesthetic reservoir. The device effectively delivers anesthetic to the skin of the subject prior to puncturing the skin by syringes, needle sticks, or other instruments intended to be inserted into the skin. In addition, this device can be used to deliver various therapeutic agents for either locally or systemically.
    Type: Application
    Filed: April 16, 2009
    Publication date: December 17, 2009
    Inventors: Totada Shantha, Jessica Shantha, Erica Shantha, Lauren Shantha
  • Publication number: 20090175957
    Abstract: A composition is provided which comprises an acidic component, generally fulvic acid, having a molecular weight not exceeding 20,000 Daltons and a low content of the elements aluminium, mercury, cadmium, chromium and lead. The acidic component is preferably carbohydrate derived and preferably using a wet oxidation process.
    Type: Application
    Filed: April 26, 2007
    Publication date: July 9, 2009
    Applicant: PFEINSMITH S.A. (pty) LTD
    Inventors: Earle John Loxton, Rudolph Johannes Malan, Stefan Coetzee
  • Publication number: 20090148539
    Abstract: The present invention includes compositions and methods for the treatment of inflammatory disease (e.g. asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic rhinitis, scleroderma, and the like), relating to inhibiting a chitinase-like molecule. The invention further includes methods to identify new compounds for the treatment of inflammatory disease, including, but not limited to, asthma, COPD and the like. This is because the present invention demonstrates, for the first time, that expression of IL-13, and of a chitinase-like molecule, mediates and/or is associated with inflammatory disease and that inhibiting the chitinase-like molecule treats and even prevents, the disease. Thus, the invention relates to the novel discovery that inhibiting a chitinase-like molecule treats and prevents an inflammatory disease.
    Type: Application
    Filed: July 18, 2008
    Publication date: June 11, 2009
    Applicant: Yale University
    Inventors: Jack A. Elias, Zhou Zhu
  • Publication number: 20090022780
    Abstract: The invention is related to gel preparations capable of absorbing as well as releasing liquid, and the use of such gel preparations in the treatment of wounds.
    Type: Application
    Filed: January 31, 2007
    Publication date: January 22, 2009
    Applicant: EURO-CELTIQUE S.A.
    Inventors: Sabine Scherer, Christian Wagner, Christian Leuner, Wolfgang Fleischer
  • Publication number: 20080299222
    Abstract: Bioactive agrichemical concentrates and compositions having improved bioactivity comprising combinations of acid solutions and conventional bioactive agrichemical actives or formulations.
    Type: Application
    Filed: May 19, 2008
    Publication date: December 4, 2008
    Inventor: Joseph J. Crudden
  • Publication number: 20080292723
    Abstract: Bioactive agrichemical concentrates and compositions having improved bioactivity comprising metal-acid solutions.
    Type: Application
    Filed: May 19, 2008
    Publication date: November 27, 2008
    Inventor: Joseph J. Crudden
  • Publication number: 20080292721
    Abstract: Bioactive agrichemical concentrates and compositions having improved bioactivity comprising metal-acid solutions.
    Type: Application
    Filed: May 19, 2008
    Publication date: November 27, 2008
    Inventor: Joseph J. Crudden
  • Publication number: 20080233207
    Abstract: An aqueous solution suitable for injection into a mammal in need thereof includes an inorganic mercury (II) containing compound present in an amount between 0.1 nanomole and 50 millimoles Hg2+ where the solution is sufficiently stable such that there is no precipitation from the solution for at least thirty days of a visable precipitate containing at least some of said mercury. In one embodiment, a buffer which stabilizes the pH of the solution at a desired pH between 3.0 and 7.0 is provided. In another embodiment, at least one salt is provided in amounts which provide sufficient ionic strength to the solution and coordination ligand to prevent precipitation of the mercury from the solution.
    Type: Application
    Filed: June 3, 2008
    Publication date: September 25, 2008
    Inventor: Yelena G. Sheptovitsky
  • Publication number: 20080118573
    Abstract: The present invention is directed to a method of treating biofilms by exposure to heavy metals selected from the group comprising metal cations such as manganese, cobalt, nickel, copper, zinc, aluminum, silver, mercury, lead, cadmium and tin; metal oxyanions such as molybdate, tungstate and chromate; and metalloid oxyanions, alone or in combination with antimicrobials. The present invention also includes compositions and methods for preparing or treating medical devices and medications.
    Type: Application
    Filed: June 21, 2005
    Publication date: May 22, 2008
    Inventors: Joe Jonathan Harrison, Raymond Joseph Turner, Howard Ceri
  • Patent number: 7357949
    Abstract: The invention relates to a microcapsule comprising an inorganic antimicrobial agent coated with a hydrophilic polymer. The hydrophilic polymer is able to absorb sufficient water as to enable the action of the encapsulated antimicrobial agent. These microcapsules are useful to impart antimicrobial activity and can be used in polymer compositions, sprays and coatings. A method of preparing the microcapsule by treatment of the antimicrobial agent with a solution of the hydrophilic polymer is provided. Another embodiment of the invention is a method of preparing the microcapsule by coating of the antimicrobial agent with a polymer precursor followed by treatment with a reactive ingredient. Another embodiment of the invention is a method of preparing the microcapsule by melt compounding the antimicrobial agent with the hydrophilic polymer followed by grinding to the desired particle size. Polymer compositions comprising the microcapsules and a matrix polymer are also provided.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: April 15, 2008
    Assignee: Agion Technologies Inc.
    Inventors: Jeffrey A. Trogolo, Frank C. Rossitto, Edward K. Welch, II
  • Patent number: 7354605
    Abstract: According to the present invention there are provided antimicrobial catheters and other medical devices having controlled release of an antimicrobial metal or metal ion. Specifically, antimicrobial catheters and other medical devices manifest antimicrobial properties as a result of the incorporation therein of antimicrobial microcapsules comprising an inorganic antimicrobial agent and a hydrophilic polymer.
    Type: Grant
    Filed: January 20, 2006
    Date of Patent: April 8, 2008
    Assignee: Aglon Technologies Inc.
    Inventors: Jeffrey A. Trogolo, Frank C. Rossitto, Edward K. Welch, II
  • Publication number: 20080057136
    Abstract: The invention relates to antimicrobial compositions that can be used for disinfecting and can be applied in various aspects of the national economy, medicine, and laboratories of all types. The antimicrobial compositions comprise a chelating metal complex compound with a monodentate bidentate or polydentate ligand that exhibits affinity to hydrogen ion, an ionogenic surfactant, and a solvent. The compositions of the invention display antiseptic properties. The antimicrobial compositions are active against Gram-positive and Gram-negative bacteria, fungi, viruses, and spores, and can be applied in a broad temperature interval. Methods of using the compositions of the present invention in the treatment and prevention of diseases caused by a variety of pathogens are further provided.
    Type: Application
    Filed: November 11, 2004
    Publication date: March 6, 2008
    Applicant: Veckis Industries Ltd.
    Inventors: Victor S. Polyakov, Valeriy V. Ermilov, Vladimir S. Kuzmin, Oleg I. Lukashov
  • Patent number: 7323452
    Abstract: A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as catalysts or “pseudo” enzymes for the oxidation. These additives include multivalent transition metal ions, as well as complexes thereof, and NAD+ which enhance the oxidation reaction. The method described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: January 29, 2008
    Assignee: Wardan, L.L.C.
    Inventors: Ward B. Bowen, Jr., Daniel S. Daniel
  • Publication number: 20070231409
    Abstract: The present disclosure relates to a drug and/or food supplement with antiviral effects, in particular for the preventive and/or therapeutic treatment of herpes labialis and/or herpes genitalis, and/or with antibacterial and/or immunomodulating and/or antiphlogistic effects and/or for the preventive and/or therapeutic treatment of affections of the prostate, containing NISYLEN® and/or Cepa and/or Euphrasia and/or Belladonna and/or Mercurius solubilis.
    Type: Application
    Filed: July 31, 2006
    Publication date: October 4, 2007
    Inventor: Klaus Huber
  • Patent number: 7094428
    Abstract: A hemostatic composition which comprises at least one procoagulant metal ion, such as silver (I) or mercury (II), and at least one procoagulant biopolymer, such as collagen, thrombin, prothrombin, fibrin, fibrinogen, heparinase, Factor VIIa, Factor VIII, Factor IXa, Factor Xa, Factor XII, von Willebrand Factor, a selectin, a procoagulant venom, a plasminogen activator inhibitor, glycoprotein IIb-IIIa, a protease, or plasma. The composition in the form of a paste, dough, glue, liquid, lyophilized powder or foam, may be provided, for application to a wound. A hemostatic device is also described which comprises a hemostatic composition as described above. The device may be in the form of, for example, a plug, bandage, gauze, cloth, tampon, membrane or sponge. Methods are also provided for prophylaxis or treatment of bleeding at a site by application to the site of the composition or device as described.
    Type: Grant
    Filed: December 10, 2002
    Date of Patent: August 22, 2006
    Assignee: The University of Medicine and Dentistry of New Jersey
    Inventors: Charles R. Spillert, Marcelle Khalil
  • Patent number: 6939566
    Abstract: Microbicidal formulations are described which are preferably ecologically friendly and non-toxic to mammals, and are highly effective against a broad spectrum of detrimental pathogenic microorganisms. The microbicidal formulation contains complexes having the formula R-M, wherein R is at least one organic chelating moiety and M is at least one metal ion which is microbicidal to at least one microorganism. These complexes can disrupt microorganism activities by penetrating the natural protecting bio-films of such microorganisms through the reaction of the R-group with the organic constituents of these microorganisms while releasing M into their intra-cellular media. Thus, this process exhibits its biocidal activities from the inside-out, contrary to other methods which rely on damaging the protective biofilms.
    Type: Grant
    Filed: January 17, 2001
    Date of Patent: September 6, 2005
    Inventors: Kareem I. Batarseh, Marwan Al-Kayed
  • Patent number: 6833362
    Abstract: A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or “pseudo” enzymes for the oxidation. Additives include the oxidant Nicotinamide Adenine Dinucleotide and a variety of other additives such as transition metal ions and complexes thereof which favor the oxidation reaction. The compositions described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.
    Type: Grant
    Filed: June 7, 2001
    Date of Patent: December 21, 2004
    Inventors: Ward Beryl Bowen, Jr., Daniel Salman Daniel
  • Publication number: 20040001894
    Abstract: This invention relates to topical compositions and a glove for protection against radiation exposure, such as that due to radiation used in medical procedures.
    Type: Application
    Filed: June 26, 2002
    Publication date: January 1, 2004
    Inventor: Jonathan S. Leibowitz
  • Patent number: 6630172
    Abstract: Disinfectant formulations are described which are preferably ecologically friendly and non-toxic to mammals and plants, and are highly effective against a broad spectrum of detrimental pathogenic microorganisms. The microbicidal formulation contains complexes having at least one metal ion which is microbicidal to at least one microorganism and potassium sodium tartrate in some form. When potassium sodium tartrate is used with these metal ions, it enhances the complex-forming properties of such metal complexes while concurrently increases their efficacy and potency at the same level of metal ion concentrations. These microbicidal formulations can be diluted in suitable proportions into aqueous systems to produce the desired dosages for each individual case, depending on the level and the severity of the contamination. The microbicidal formulations can be applied by conventional methods, e.g., spraying, soaking, fogging, impregnation, and the like.
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: October 7, 2003
    Inventor: Kareem I. Batarseh
  • Publication number: 20030118664
    Abstract: The invention relates to a microcapsule comprising an inorganic antimicrobial agent coated with a hydrophilic polymer. The hydrophilic polymer is able to absorb sufficient water as to enable the action of the encapsulated antimicrobial agent. These microcapsules are useful to impart antimicrobial activity and can be used in polymer compositions, sprays and coatings. A method of preparing the microcapsule by treatment of the antimicrobial agent with a solution of the hydrophilic polymer is provided. Another embodiment of the invention is a method of preparing the microcapsule by coating of the antimicrobial agent with a polymer precursor followed by treatment with a reactive ingredient. Another embodiment of the invention is a method of preparing the microcapsule by melt compounding the antimicrobial agent with the hydrophilic polymer followed by grinding to the desired particle size. Polymer compositions comprising the microcapsules and a matrix polymer are also provided.
    Type: Application
    Filed: December 21, 2001
    Publication date: June 26, 2003
    Inventors: Jeffrey A. Trogolo, Frank C. Rossitto, Edward K. Welch
  • Patent number: 6579541
    Abstract: The invention relates to a method and composition for destroying or inhibiting proliferation of microbes using oxidative fluorinator compounds. Fluoride salts that do not dissociate completely in aqueous solutions, such as tri- or tetravalent transition metal fluorides, inert gas fluorides, or tri- or tetravalent rare earth fluorides, are effective antimicrobial agents even at levels up to about 20 ppm, when used alone or in conjunction with a strong oxidizer.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: June 17, 2003
    Assignee: Marantech Holding, LLC
    Inventor: Marvin S. Antelman
  • Patent number: 6521265
    Abstract: A method of arresting the flow of blood and other protein containing body fluids flowing from an open wound and for promoting wound healing. In the method, a substantially anhydrous compound of a salt ferrate is provided for a unique use which, when hydrated after mixing with a victim's own blood or other aqueous media, produces Fe+++ thereby promoting clotting when applied in a paste form to the wound for a time sufficient to arrest substantial further blood and other body fluid flow from the wound. The compound is formed of a ferrate (VI) salt taken from the group consisting of H, Li, Na, K, Rb, Cs and Fr. However, to decrease or eliminate stinging sensation, the compound may be formed having a ferrate (VI) salt taken from the group consisting of Be, Mg, Ca, Sr, Ba, Ra, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Ge, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, In, Sn, Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, TI, Pb, Bi, Al, As, NH4 and N(C4H9)4.
    Type: Grant
    Filed: June 13, 2000
    Date of Patent: February 18, 2003
    Assignee: Biolife, L.L.C.
    Inventor: James A. Patterson
  • Patent number: 6426093
    Abstract: A biocidal composition composed of a ternary complex of a negatively-charged biocide, a transition metal ion and chelator has synergistic biocidal effects as compared with a composition of each of the components alone. The chelator is preferably a neutral or positively-charged chelator. The ternary complex may be used for killing or inhibiting the growth of living cells.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: July 30, 2002
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Mordechai Chevion, Benzhan Zhu, Svetlana Schechtman
  • Publication number: 20010021394
    Abstract: The present invention relates to compositions and methods of induction of a cellular stress response and a protected phenotype using heavy metal ions. The invention relates to methods of protecting a mammal against injury caused by a noxious condition by administering to the mammal a heavy metal in sufficient quantity and under appropriate conditions to induce a sufficient cellular stress response to provide protection (partial or complete) against injury caused by a noxious condition. The invention also relates to methods of inducing a cellular stress response in a mammal by administering a heavy metal in sufficient quantity and under appropriate conditions to induce a cellular stress response to protect the mammal against injury caused by a noxious condition.
    Type: Application
    Filed: January 11, 2001
    Publication date: September 13, 2001
    Inventor: George A. Perdrizet
  • Patent number: 6242009
    Abstract: Microbicidal formulations are described which are preferably ecologically friendly and non-toxic to mammals, and are highly effective against a broad spectrum of detrimental pathogenic microorganisms. The microbicidal formulation contains complexes having the formula R-M, wherein R is at least one organic chelating moiety and M is at least one metal ion which is microbicidal to at least one microorganism. These complexes can disrupt microorganism activities by penetrating the natural protecting bio-films of such microorganisms through the reaction of the R-group with the organic constituents of these microorganisms while releasing M into their intra-cellular media. Thus, this process exhibits its biocidal activities from the inside-out, contrary to other methods which rely on damaging the protective biofilms.
    Type: Grant
    Filed: April 20, 1999
    Date of Patent: June 5, 2001
    Inventors: Kareem I. Batarseh, Marwan Al-Kayed
  • Patent number: 6071542
    Abstract: The present invention provides antibacterial zeolite exhibiting a less discoloring action, obtained by treating the surface of zeolite supporting an antibacterial metal with 0.5 to 20% by weight, based on said zeolite, of a composition comprising (A) 100 parts by weight of a hydrolyzable silane and/or oligomer thereof which comprises 10 to 100% by weight of a hydrolyzable silane and/or oligomer thereof having an aryl group; (B) 1 to 1000 parts by weight of an organopolysiloxane having a basic nitrogen atom; and (C) 0.2 to 250 parts by weight of an acid which is soluble in water and which can form a salt with the aforesaid (B). The present antibacterial zeolite exhibits a remarkably less action of discoloring an organic polymer which contains the antibacterial zeolite when the polymer blend is placed under the influence of heat or the sunshine.
    Type: Grant
    Filed: November 13, 1997
    Date of Patent: June 6, 2000
    Assignee: Kanebo Ltd.
    Inventors: Takeo Tanimoto, Noboru Watanabe, Kazuhiko Nakashima, Ryuhei Matsuo, Manabu Nagata, Yuji Shingai, Tatsuo Otani
  • Patent number: 5916356
    Abstract: This invention relates to preservative compositions which comprise a biocidal metal compound and an fungicidal compound containing a triazole group. Methods of treating wood with the composition are also described.
    Type: Grant
    Filed: June 2, 1997
    Date of Patent: June 29, 1999
    Assignee: Hickson International PLC
    Inventors: Gareth Williams, Judith Ann Cornfield, Janet Brown, Neil Patrick Ryan
  • Patent number: 5662886
    Abstract: A modified amalgam composition forming an adhesive bond with tooth structure treated with a dental adhesive. The modified amalgam can be prepared by admixing particulate additives into conventional amalgam alloy powder to form a modified alloy powder and then triturating the modified alloy powder with mercury. The modified amalgam when applied to a prepared tooth cavity that has been precoated with an acrylate- or methacrylate-functional dental adhesive results in an adhesive bond between the modified amalgam and coated tooth structure. Preferred particulate additives for the amalgam alloy powder are acrylate- or methacrylate-functional polymers, metal salts of acrylates or methacrylates, nonmetallic fillers, oxidizing agents and reducing agents.
    Type: Grant
    Filed: January 8, 1991
    Date of Patent: September 2, 1997
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Joel David Oxman, Jon Wallace Fundingsland
  • Patent number: 5441746
    Abstract: This invention describes an electromagnetic wave-absorbing surface modified magnetic particle for use in medical applications. The magnetic particles are coated with an amphipathic organic compound and an amphipathic vesicle forming lipid. These particles may be used in a method of treatment of cancer, as well as for the treatment of infectious disease. For cancer treatment the invention comprises providing a patient said coated particles, absorbing the coated particle intracellularly into the cancer cell, and subjecting the patient to an alternating electromagnetic field to inductively heat the magnetic core particle along with the cancer cells. The inductive heating of the magnetic core particle is then continued so as to achieve an increase in intracellular temperature which selectively kills the cancer cells.
    Type: Grant
    Filed: May 5, 1993
    Date of Patent: August 15, 1995
    Assignee: Molecular BioQuest, Inc.
    Inventor: Mark S. Chagnon
  • Patent number: 5413789
    Abstract: The invention provides a novel antibacterial compound and a process for producing it. Futhermore, the invention provides a novel antibacterial polymer composite comprising a polymer and the antimicrobial compositon.
    Type: Grant
    Filed: May 17, 1993
    Date of Patent: May 9, 1995
    Assignees: Hagiwara Research Corp., Japan Electronic Materials Corp.
    Inventors: Zenji Hagiwara, Masao Okubo
  • Patent number: 5389377
    Abstract: A liposome composition which comprises a substantially uniform sized inorganic core coated with an amphipathic organic compound and further coated with a second amphipathic vesicle forming lipid. Also disclosed are novel phenyl lipid compounds which serve as the amphipathic vesicle forming lipid and methods are described for delivering a drug for slow release into the blood stream, and for targeting a selected tissue or cells with the inorganic core liposome compositions.
    Type: Grant
    Filed: October 7, 1992
    Date of Patent: February 14, 1995
    Assignee: Molecular Bioquest, Inc.
    Inventors: Mark S. Chagnon, John R. Ferris, Tracy J. Hamilton, Edwin A. Rudd, Michelle J. Carter
  • Patent number: 5298252
    Abstract: A silica gel based heat-resistant and weatherproof antimicrobial composition having an aluminosilicate layer on the surfaces of pores in the silica gel as substituted by silver and an optional antimicrobial metal, said composition containing ion-exchangeable metals that are chiefly an alkali metal and that are present in an amount of up to 2.57 mmol per gram of said composition on an anhydrous basis.
    Type: Grant
    Filed: August 29, 1991
    Date of Patent: March 29, 1994
    Assignees: Hagiwara Research Corp., Japan Electronic Materials Corporation
    Inventors: Zenji Hagiwara, Masao Okubo
  • Patent number: 5244667
    Abstract: The present invention provides a novel antimicrobial composition and a process for preparing the composition which composition is useful as antimicrobial and/or bactericidal material. The antimicrobial composition of the invention comprises silica gel and an antimicrobial coat of aluminosilicate on the surface of the silica gel, said composition having a pore volume of at least 0.3 cm.sup.3 /g and a specific surface area of at least 100 m.sup.2 /g. The aluminosilicate coat consists of either partial or complete substitution of ion-exchangeable metal ion (M) in aluminosilicate solid particles represented by the formulaxM.sub.2/n O.Al.sub.2 O.sub.3.ySiO.sub.2.zH.sub.2 O,wherein x and y represent the numbers of molecules of the metal oxide and silicon dioxide, respectively, M is an ion-exchangeable metal, n is the atomic valence of M, and z is the number of molecules of water.
    Type: Grant
    Filed: February 28, 1991
    Date of Patent: September 14, 1993
    Assignees: Hagiwara Research Corp., Japan Electronic Materials Corporation
    Inventors: Zenji Hagiwara, Masao Okubo
  • Patent number: 5208042
    Abstract: Oleaginous ointment compositions for topical antibacterial treatment containing about 0.5 to about 1.5% yellow mercuric oxide by weight and additionally containing organic acids selected from the group consisting of alkanoic acids of formula CH.sub.3 (CH.sub.2).sub.n COOH, wherein n is an integer from 4 to 22, and arylalkanoic acids of formula C.sub.6 H.sub.5 (CH.sub.2).sub.n COOH, wherein n is an integer from 0 to 17, to increase the color stability of the compositions. A method of making the novel stabilized ointment compositions is also disclosed.
    Type: Grant
    Filed: May 10, 1991
    Date of Patent: May 4, 1993
    Assignee: Del Laboratories, Inc.
    Inventors: Harry Gordon, Henry Chan, Howard Brasch
  • Patent number: 5102670
    Abstract: The invention relates to a method for treating or preventing ocular swelling and corneal-conjunctival inflammation. This is accomplished by administering to the eye of a subject, either before or after exposure to an ocular swelling stimulus, an amount of a heme oxygenase inducing agent sufficient to increase levels of heme oxygenase in the eye and thereby to reduce or to regulate the amount of 12(R) hydroxyeicosatetraenoic and 12(R) DiHETE acids present. Particularly preferred agents include stannous compounds, such as SnCl.sub.2, other metals, heme derivatives and Vitamin B12. These compounds may be administered in various forms.
    Type: Grant
    Filed: September 14, 1990
    Date of Patent: April 7, 1992
    Inventors: Nader G. Abraham, Michal L. Schwartzman, Michael W. Dunn, Richard D. Levere