Bismuth Patents (Class 424/653)
  • Patent number: 5702729
    Abstract: The subject invention encompasses methods for the prevention and treatment of a human or lower animal subject having a gastrointestinal disorder caused or mediated by algae and/or cyanobacteria comprising administering bismuth to the subject.
    Type: Grant
    Filed: December 7, 1995
    Date of Patent: December 30, 1997
    Assignee: The Procter & Gamble Company
    Inventor: Jamesina Anne Fitzgerald
  • Patent number: 5656652
    Abstract: Compositions for oral administration for the treatment of gastric disorders comprising histamine H.sub.2 -receptor antagonist, and antacid, optimally buffered to promote local absorption of the H.sub.2 -receptor antagonist, wherein the quantity of H.sub.2 -receptor antagonist per unit dosage form is less than 25 mg.
    Type: Grant
    Filed: June 15, 1994
    Date of Patent: August 12, 1997
    Assignee: SmithKline Beecham plc
    Inventor: Adrian Francis Davis
  • Patent number: 5629026
    Abstract: Compositions for oral administration for the treatment of gastric disorders comprising histamine H.sub.2 -receptor antagonist and antacid, optionally buffered to promote local absorption of the H.sub.2 -receptor antagonist, wherein the quantity of H.sub.2 -receptor antagonist per unit dosage form is less than 25 mg.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: May 13, 1997
    Assignee: SmithKline Beecham plc
    Inventor: Adrian F. Davis
  • Patent number: 5618564
    Abstract: The present invention is directed to a method for the treatment of Helicobacter pylori infection wherein a composition containing protease and an antibacterial agent as active ingredients, which can remove Helicobacter pylori from a stomach at high probability without causing side effects or the occurrence of resistant bacteria, and which can treat and prevent peptic ulcer caused by Helicobacter pylori infection and can prevent the recurrence of peptic ulcer is employed.
    Type: Grant
    Filed: July 27, 1995
    Date of Patent: April 8, 1997
    Assignees: Ken Kimura, Kaken Pharmaceutical Co., Ltd.
    Inventors: Ken Kimura, Yushi Taniguchi, Kiichi Satoh, Kouji Saifuku, Ken Kihira, Kenichi Ido, Yukio Yoshida, Takuya Takimoto
  • Patent number: 5601848
    Abstract: Method for the treatment of human and lower animals having an infectious gastrointestinal disorder, comprising the step of administering from about 50 to about 5000 milligrams of bismuth to said subject, per day, for from 3 to 56 days. Preferred processes also include a step for performing a diagnostic step on the subject for detection of campylobacter-like organism infection of the subject.
    Type: Grant
    Filed: July 8, 1987
    Date of Patent: February 11, 1997
    Assignee: The Procter & Gamble Company
    Inventor: Barry J. Marshall
  • Patent number: 5597550
    Abstract: An apparatus and process for administering minerals to the human body by mixing pre-selected particulated minerals with graphite and coal tar to form a bar (10a), vaporizing the bar (10a) to form a mineral rich vapor, and directing the vapor to a patient's skin using an enclosure (30).
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: January 28, 1997
    Inventor: Buxing Mo
  • Patent number: 5476669
    Abstract: A method is disclosed for preventing the recurrence of duodenal ulcer associated with Campylobacter pylori (Helicobacter pylori) infection in a patient suffering from duodenal ulcer disease associated with Campylobacter pylori infection by administering a pharmaceutically acceptable bismuth compound, a first antibiotic selected from the group consisting of tetracycline and penicillins, and a second antibiotic which is metronidazole.
    Type: Grant
    Filed: August 31, 1992
    Date of Patent: December 19, 1995
    Assignees: Examed Australia Pty. Ltd., Ostapat Pty. Limited, Gastro Services Pty. Limited, Capability Services Pty. Limited
    Inventor: Thomas J. Borody
  • Patent number: 5413789
    Abstract: The invention provides a novel antibacterial compound and a process for producing it. Futhermore, the invention provides a novel antibacterial polymer composite comprising a polymer and the antimicrobial compositon.
    Type: Grant
    Filed: May 17, 1993
    Date of Patent: May 9, 1995
    Assignees: Hagiwara Research Corp., Japan Electronic Materials Corp.
    Inventors: Zenji Hagiwara, Masao Okubo
  • Patent number: 5407688
    Abstract: The present invention relates to pharmaceutical compositions useful for treating or preventing gastrointestinal disorders. These compositions comprise a campylobacter-inhibiting antimicrobial agent such as nitrofurantoin and bismuth subsalicylate, and a histamine-2 receptor blocking anti-secretory agent such as cimetidine.The present invention further relates to methods for treating or preventing gastrointestinal disorders in humans or lower animals by administering a campylobacter-inhibiting antimicrobial agent and a histamine-2 receptor blocking anti-secretory agent.
    Type: Grant
    Filed: October 30, 1992
    Date of Patent: April 18, 1995
    Assignee: The Procter & Gamble Company
    Inventor: Geoffrey Place
  • Patent number: 5403830
    Abstract: The present invention relates to pharmaceutical compositions useful for treating or preventing gastrointestinal disorders. These compositions comprise a bismuth-containing agent, preferably a campylobacter-inhibiting bismuth-containing agent such as bismuth subsalicylate and bismuth subcitrate, and a histamine-2 receptor blocking anti-secretory agent such as cimetidine.The present invention further relates to methods for treating or preventing gastrointestinal disorders in humans or lower animals by administering a bismuth-containing agent and a histamine-2 receptor blocking anti-secretory agent.
    Type: Grant
    Filed: January 10, 1992
    Date of Patent: April 4, 1995
    Assignee: The Proctor & Gamble Company
    Inventor: Geoffrey Place
  • Patent number: 5399356
    Abstract: A process for making a bismuth-containing solid dose form composition is described which includes an agglomeration step with binder in a high shear mixer.
    Type: Grant
    Filed: March 24, 1994
    Date of Patent: March 21, 1995
    Assignee: The Procter & Gamble Company
    Inventors: Francis B. Chapura, Daniel L. Barone, Michael G. Colacino
  • Patent number: 5298252
    Abstract: A silica gel based heat-resistant and weatherproof antimicrobial composition having an aluminosilicate layer on the surfaces of pores in the silica gel as substituted by silver and an optional antimicrobial metal, said composition containing ion-exchangeable metals that are chiefly an alkali metal and that are present in an amount of up to 2.57 mmol per gram of said composition on an anhydrous basis.
    Type: Grant
    Filed: August 29, 1991
    Date of Patent: March 29, 1994
    Assignees: Hagiwara Research Corp., Japan Electronic Materials Corporation
    Inventors: Zenji Hagiwara, Masao Okubo
  • Patent number: 5256684
    Abstract: Methods, for the treatment of humans and lower animal subjects having a gastrointestinal disorder, comprising administering bismuth and administering an antimicrobial. From about 50 to about 5000 milligrams of bismuth are administered, per day, for from 3 to 56 days. A safe and effective amount of antimicrobial is administered for from 1 to 21 days. Preferred processes also include a step for performing a diagnostic test on the subject for detection of a campylobacter-like organism infection of the subject. The invention also provides compositions containing a safe and effective amount of bismuth and a safe and effective amount of antimicrobial.
    Type: Grant
    Filed: July 26, 1991
    Date of Patent: October 26, 1993
    Assignee: The Procter & Gamble Company
    Inventor: Barry J. Marshall
  • Patent number: 5244667
    Abstract: The present invention provides a novel antimicrobial composition and a process for preparing the composition which composition is useful as antimicrobial and/or bactericidal material. The antimicrobial composition of the invention comprises silica gel and an antimicrobial coat of aluminosilicate on the surface of the silica gel, said composition having a pore volume of at least 0.3 cm.sup.3 /g and a specific surface area of at least 100 m.sup.2 /g. The aluminosilicate coat consists of either partial or complete substitution of ion-exchangeable metal ion (M) in aluminosilicate solid particles represented by the formulaxM.sub.2/n O.Al.sub.2 O.sub.3.ySiO.sub.2.zH.sub.2 O,wherein x and y represent the numbers of molecules of the metal oxide and silicon dioxide, respectively, M is an ion-exchangeable metal, n is the atomic valence of M, and z is the number of molecules of water.
    Type: Grant
    Filed: February 28, 1991
    Date of Patent: September 14, 1993
    Assignees: Hagiwara Research Corp., Japan Electronic Materials Corporation
    Inventors: Zenji Hagiwara, Masao Okubo
  • Patent number: 5198230
    Abstract: This invention provides a recipe for making a detoxification medicine named DTS (Deities) for curing drug addiction. This DTS (Deities) medicine comprises no narcotic but mainly is made up by several kinds of effective ingredients of biological substances refined from various natural herbs and bioproducts. Drug addicts can be weaned and cured safely from addiction induced by Heroin, Cocaine, Morphine, Amphetamines, Hemp or Opium, and other substances within 7-30 days, by means of DTS (Deities) which can get rid of drug poisons present in an addict's blood and marrow. Further, DTS (Deities) can also be used to clear away tobacco tar and nicotine deposits so that it serves to wean from cigarette smoking as well.
    Type: Grant
    Filed: January 8, 1991
    Date of Patent: March 30, 1993
    Inventor: Liu C. Wen
  • Patent number: 5196205
    Abstract: A method is disclosed for preventing recurrence of duodenal ulcer associated with Campylobacter pylori infection in a patient suffering from duodenal ulcer disease associated with Campylobacter pylori infection by administering a pharmaceutically acceptable bismuth compound; a first antibiotic selected from the group consisting of tetracycline and penicillins and second antibiotic which is metronidazole.
    Type: Grant
    Filed: June 12, 1990
    Date of Patent: March 23, 1993
    Inventor: Thomas J. Borody
  • Patent number: 5165975
    Abstract: A contrast medium-containing tube is provided which is a thermoplastic resin tube incorporated with a white bismuth compound composed mainly of bismuth oxide containing 70-85 wt % bismuth and having a particle diameter substantially smaller than 20 .mu.m. This contrast medium-containing tube looks white and remains white in appearance over a long period of time. It is easy to carry out extrusion molding for producing this contrast medium-containing tube.
    Type: Grant
    Filed: April 30, 1991
    Date of Patent: November 24, 1992
    Assignee: Junkosma Co., Ltd.
    Inventor: Keigo Goshiki
  • Patent number: 5128140
    Abstract: Oral pharmaceutical compositions in unit dosage form suitable for swallowing (especially capsules) comprising a safe and effective amount of a soluble bismuth-containing pharmaceutical agent (preferably a pharmaceutically-acceptable salt suitable for oral co-administration of bismuth and an H.sub.2 receptor blocking anti-secretory agent), and optionally one or more pharmaceutically-acceptable carrier materials, wherein the packing density of the dosage unit is less than about 1 g/ml.
    Type: Grant
    Filed: January 14, 1991
    Date of Patent: July 7, 1992
    Assignee: The Procter & Gamble Company
    Inventors: Francis B. Chapura, Sekhar Mitra
  • Patent number: 5085863
    Abstract: A tube comprises a wall formed from thermoplastic material. The wall is provided with an X-ray opaque agent comprised of a white bismuth compound mixture of bismuth oxide and a white bismuth salt such as bismuth nitrate and bismuth sulfate, the bismuth compound mixture having a bismuth content of 83 to 88% by weight.
    Type: Grant
    Filed: April 17, 1990
    Date of Patent: February 4, 1992
    Assignee: Junkosha Co., Ltd.
    Inventor: Keigo Goshiki
  • Patent number: 5013560
    Abstract: Microbially-stable liquid pharmaceutical suspensions for oral administration comprising a bismuth-containing pharmaceutical agent, benzoic acid, sorbic acid, a suspension system and water, and wherein said compositions have a pH within the range of from about 3.0 to about 5.5. These compositions are efficacious, and have good aesthetics and good storage stability.
    Type: Grant
    Filed: March 17, 1989
    Date of Patent: May 7, 1991
    Assignee: The Procter & Gamble Company
    Inventors: Laura L. Stentz, Jerry R. Maney, Thomas E. Sox
  • Patent number: 4956386
    Abstract: A process for producing an effective anti-ulcer preparation in the form of a dry powder by spray-drying a colloidal solution comprising bismuth citrate, ammonia and a polyhydric alcohol.
    Type: Grant
    Filed: July 17, 1985
    Date of Patent: September 11, 1990
    Assignee: Gist-Brocades N.V.
    Inventors: Christopher J. McLoughlin, Ross B. Himstedt
  • Patent number: 4906450
    Abstract: The radionuclide Tin, Sn-121 in a carrier hydroxide aggregate is disclosed for the treatment of arthritis and, in particular, rheumatoid arthritis of the hands, the interphalangeal joints of the fingers and the metacarpal joints of the hand.The radioactive compound disclosed preferably has a particle size of <90 microns. The beta energy emission associated with Tin, Sn-121 has an energy of 0.38 meV. There are no gamma photons emited during the decay of Tin, Sn-121 to stable Antimony Sb-121. The half life of Tin, Sn-121 is 27.06 hours.The method of preparation of the compound is disclosed along with the method of administration to the patient in need thereof.
    Type: Grant
    Filed: March 26, 1987
    Date of Patent: March 6, 1990
    Inventors: Ephraim Lieberman, Maurice E. Bordoni, Alfred K. Thornton