Abstract: Transdermal delivery systems for the systemic delivery of memantine are described, wherein the system comprises a drug reservoir layer and an adhesive layer, optionally together with one or more intermediate and/or supporting layers, wherein the drug reservoir layer comprises an acrylate polymer or copolymer, a permeation enhancer, a carrier, and memantine base generated in situ by reaction of a memantine salt and an alkaline salt. Compositions and kits comprising the various components, e.g., drug reservoir and/or adhesive compositions are described. Methods relating to treatment of CNS disorders, e.g., Alzheimer's disease and/or dementia, using the aforementioned transdermal delivery devices and/or compositions are also described.

Abstract: Tannin-containing compositions and methods of using same to enhance or maintain immune function during simplified nutrition feeding. Pharmaceutical compositions, including enteral nutrition compositions, are provided. The compositions comprise such tannins as proanthocyanidins and/or hydrolysable tannins. Administering the tannins to the gastrointestinal tract of a subject receiving simplified nutrition, such as with enteral nutrition therapy or parenteral nutrition therapy, attenuates or prevents deleterious effects on the gastrointestinal immune system that would otherwise occur with the simplified nutrition.

Abstract: Provided is an information processing system capable of effectively preventing a user's failure to take his or her basal body temperature. The base time setter 301 sets, as a base measurement time, a time used as a basis for a user to take the user's body temperature after awakening, based on the times at which the user's body temperatures were measured. The sleep duration estimator 302 estimates the user U's most recent sleep duration. When the user's most recent sleep duration exceeds a predetermined threshold value, the alarm controller 303 causes an alarm to sound at the base measurement time.

Abstract: The present invention relates to the stable pharmaceutical composition of a suitable hypolipidemic agent. Preferably, the present invention discloses novel formulations of the compound of formula (I), or pharmaceutically acceptable salts of compounds of formula (I). More particularly the present invention relates to the stable pharmaceutical composition of compounds of formula (I) comprising compounds of formula (I) or its pharmaceutically acceptable salts, wherein the pH of the formulation is maintained above 7.

Abstract: A powder composition for the post-milking teat disinfection of dairy animals is described. In particular, said composition has proven to be advantageously effective as bactericidal agent, while without causing irritation or reddening of the skin.

Abstract: Embodiments of the presently-disclosed subject matter include compositions that include iodine or salts thereof as well as methods administering the same to subjects in need thereof. In some embodiments the compositions comprise an aqueous solution, a surfactant, a cosurfactant, an oil, and iodine or salts thereof. The composition can be an emulsion. Methods for administration include topical administration, and in some embodiments the compositions can be administered transdermally by applying the composition directly to the skin of a subject. In some embodiments the compositions are topically administered with a spray applicator that dispenses a predetermined amount of the composition upon being actuated.

Abstract: A composition for dissolving or reducing the viscosity of sputum on a surface of a device includes an effective amount of glycerol and an effective amount of dextran sulfate in a saline solution. The effective amount of glycerol is between about 30-50% and the effective amount of dextran sulfate is between about 10-30%. The composition may further include an antimicrobial agent.

Abstract: Contaminants are filtered from a fluid flow stream and the filter is regenerated by a process including steps of: providing a filter material comprising both carbon and potassium iodide; passing a contaminated fluid stream in contact with the filter material; adsorbing contaminants from the fluid stream onto surfaces in the filter material; passing an electric current through the filter material with adsorbed contaminant thereon; disassociating contaminant from the surfaces of the filter material; and removing disassociated contaminant from the filter material by carrying away the disassociated contaminant in a fluid flow mass. Separately, a stable, active iodine solution is also provided for numerous deodorizing and disinfecting applications.

Abstract: The invention relates to the field of medicine, particularly to medical preparations of anti-bacterial, anti-ulcer and immune simulating effects, which can be used in injection form. The medical preparation “RENESSANS” contains components in the following ratio (wt %): Iodine 0.4-2.0 Potassium Iodide 0.8-4.0 Starch 10.0-40.0 Ascorbic acid 0.4-2.0 Glucose 1.2-4.8 Sodium chloride 0.3-1.8 Purified water all the rest A pharmaceutically effective amount of the medical preparation is administered intravenously, intramuscularly, or orally.

Abstract: Antimicrobial solutions and delivery systems for them use liquid antimicrobial solutions with: at least 80% of total weight of a carrier liquid comprising water, alcohol or a mixture of water and alcohol; at least 0.0001% by weight of the solution of I2; at least 0.0001% by weight of CuSO4; and sufficient acid in the solution top provide a pH of less than 7.0. A buffering system is also preferable in the solution, and the solution may be provided directly as a liquid, as a spray, as a gel, imbibed and carried in a wipe, encapsulated solution, segregated droplets of solution (in carrying layers of particles, dispersed in a solid of gel carrier) and the like.

Abstract: An article or material is applied to the environment of the body of an animal (including humans) to provide both absorbency and antimicrobial activity. The article or material may comprise a water absorbent material; and a composition that reacts with water to produce molecular iodine. The composition provides a local concentration (in the water) of at least 10 parts per million iodine in water carried by the material (that is actual water supported by the water absorbent material) when the material has 5% by weight of water present in the water absorbent. The material may be a flowable material, or the article may be diaper, sanitary pad, bandage, adhesive pad or wrap for an animal.

Abstract: The invention to provide a carbon dioxide mist pressure bath system which is possible to cause the carbon dioxide mist to be absorbed efficiently through the skin and mucous membrane of the human living-body. The system comprises a carbon dioxide supply means 11; a liquid supply means 21; a carbon dioxide mist generating means 31 for pulverizing and dissolving carbon dioxide and the liquid to generate the carbon dioxide mist; a living-body cover member 41 for covering the skin and mucous membrane of the living-body and formed with a space of sealing inside the carbon dioxide mist generated by the carbon dioxide mist generating means 31; and a liquid circulation means 61 for again supplying a liquid collected in the carbon dioxide mist generating means 31 into the carbon dioxide mist generating means.

Abstract: The invention to provide a carbon dioxide mist pressure bath system which is possible to cause the carbon dioxide mist to be absorbed efficiently through the skin and mucous membrane of the human living-body. The system comprises a carbon dioxide supply means 11; a liquid supply means 21; a carbon dioxide mist generating means 31 for pulverizing and dissolving carbon dioxide and the liquid to generate the carbon dioxide mist; a living-body cover member 41 for covering the skin and mucous membrane of the living-body and formed with a space of sealing inside the carbon dioxide mist generated by the carbon dioxide mist generating means 31; a liquid circulation means 61 for again supplying a liquid collected in the carbon dioxide mist generating means 31 into the carbon dioxide mist generating means; and a pressurization means 81 for pressurizing the inside of the living-body cover member 41.

Abstract: A composition produces antioxidant, immunomodulated, and antitumorous effects. The composition includes tannic acid, potassium iodide, and ascorbic acid. The tannic acid, the potassium iodide; and the ascorbic acid preferably are in a weight ratio of 3:1:1. The potassium iodide is preferably in a mole ratio with the tannic acid of 1:2.5 to 3.5. The composition can be used in methods for treating skin neoplasms by dissolving the composition in a physiological solution and administering the solution intravenously.

Abstract: A method for killing or substantially eradicating a pathogen in the upper respiratory tract of a mammal is disclosed. The method comprises generating molecular iodine (I2) in situ using an oxidant-reductant reaction with a minimum concentration of at least about 25 ppm of I2 and I2 comprises at least 40% of the total iodine atoms. A method for inhibiting superantigens using molecular iodine is also disclosed.

Abstract: A beverage for minimizing or reducing jet lag symptoms preferably includes vitamin B3, vitamin B5, vitamin B6, vitamin B12, vitamin D, zinc, calcium, iodine, magnesium, manganese, ginseng, ginkgo biloba, grape seed extract, Echinacea extract and water. A method for minimizing or reducing jet lag symptoms including ingestion of the beverage by a traveler, one hour prior to a flight, and/or during the flight, and/or after a flight.

Abstract: A process reduces the insect, arthropod or pest content in land mass by providing molecular iodine in the land mass in a concentration in aqueous material in the land mass of at least 10 parts per million. The molecular iodine may be added in gaseous or liquid or solid state, and may be formed in situ in the land mass using available water in the reaction.

Abstract: A dental curable composition comprises (A) a polymerizable monomer and (B) an organic amine-based polymerization initiator, wherein (A?) a long-chain polymerizable monomer having a chain length of 17 or more atoms is contained in the component (A) and/or (C) a soft resin material are/is contained in the composition, and when the amount (parts by weight) based on 100 parts by weight of the component (A) of the component (A?) is represented by [a?] and the amounts (parts by weight) based on 100 parts by weight of the total of the components (A) and (B) of the components (A), (B) and (C) are represented by (a), (b) and (c), respectively, 70?(a)?99.99, 0.01?(b)?5 30, 1?[a?]/5+(c)/1, 0?[a?]?95, and 0?(c)?250.

Abstract: The invention is to provide a gas mist pressure bath system, which is possible to control the amount of gas and liquid, pressure and others, and cause a gas mist to be absorbed through a skin and mucous membrane of a human living-body under an optimum condition, in which a mist is prepared by pulverizing and dissolving carbon dioxide or oxygen or a mixed gas of carbon dioxide and Oxygen and a liquid at a density of not less than a predetermined value, and the thus prepared gas mist is directly contacted to the skin and mucous membrane of the living-body, the gas mist pressure bath system comprises a gas supply, a liquid supply, a gas mist supply for generating and supplying the gas mist prepared by the liquid nozzle of pulverizing and dissolving the gas supplied from the gas supply as well as the liquid supplied from the liquid supply, and the living body cover member of covering the skin and mucous membrane of the living-body and forming a space of sealing the gas mist inside thereof, and the gas mist pressu

Abstract: A method for rejuvenating a reverse osmosis (RO) membrane which is subject to biofilm and other contaminants in an aqueous system through the use of a free molecular iodine solution at a pH of about 2.2 to 4.0.

Abstract: Memantine compositions and methods of use are described herein. In some embodiments, the compositions comprise memantine and an absorption enhancer, or memantine and an elimination enhancer, or memantine and an absorption enhancer and an elimination enhancer.

Abstract: The present invention is related to the composition and methods of manufacture of orally-dissolvable, edible films as a vehicle for the non-invasive administration of nitroglycerin, as well as other therapeutic agents either with or without nitroglycerin, through the mucosal tissues of the oral cavity. The films include a water soluble film-forming polymer such as pullulan. Methods for producing the films are also disclosed.

Abstract: An ingestible nutritional substance (supplement and the like) including vitamins, minerals and other ingredients beneficial to a woman and/or her child that a woman may take at a time of her life surrounding pregnancy. This includes by ingesting determined and suited types and amounts of ingredients, including at selected times, to best assist the woman and/or infant's needs at the respective times. The ingestible supplement can be formulated for drinking with appropriate nutritional and health benefits as well as with desired lifestyle and taste and aesthetic attributes. The dosing and packaging of the supplement to best suit a specific class of woman's and baby's needs are also described. Other aspects are directed to the preservation, storage and dispensation of one or more ingredients that may not be stable with one another during storage.

Abstract: Breast cancer is a common cancer in women. Early diagnosis and treatments are vital for better outcomes. This formula consists of a liquid anti-disease anti-cancer formula that can be delivered to the source where breast cancer begins. Method of treating breast disease, including cancer, with a formula and a means of delivery with a topical, intraductal, ductal, and/or intraductal infusion to prevent the formation of cancer or precursors to cancer or atypia or other form of abnormal breast tissue or to treat breast diseases of all kinds. May include homeopathic remedies to be used topically or inside the breast with a delivery method to those regions and may be processed with or without photonic programming or an ionic delivery system for greater effectiveness and use against degenerative diseases or cancerous or precancerous diseases, precursors of breast disease, inflammatory breast disease, or accumulation of toxins in the breast tissue.

Abstract: A process reduces the microbial content in land mass by providing molecular iodine in the land mass in a concentration in aqueous material in the land mass of at least 5 or 10 parts per million. The molecular iodine may be added in gaseous or liquid or solid state, and may be formed in situ using available water, added water and/or alcohol in the reaction.

Abstract: The present invention relates to an anti-bacterial, anti-virus, and anti-fungus composition, its preparation and use. The composition of the present invention mainly includes the following three ingredients in an adequate ratio: (A) a metal compound having a catalytic function; (B) a mixture of a coenzyme having reducing ability and a quinone, and (C) an additive. The anti-bacterial, anti-virus, and anti-fungus composition of the present invention is capable of destroying viruses as well as killing bacterial and fungi. Therefore, the composition can be formulated as an aerosol and a film for applying to protection devices such as respirators, masks, gloves, filters, condoms, etc. The present composition can also be used in household, vehicle, hospital, school, restaurant, hotel, internet coffee shop for applying to filter of air-conditioner, tap, stool, interior of elevator and its keyboard.

Abstract: A strip, which is both edible and dissolvable, is provided comprising a film and a dosage of at least 2% of the reference daily intake (RDI) of at least one dietary supplement for malnutrition or to prevent/treat alcohol induced hangovers. A method for treating malnutrition and/or preventing and treating alcohol-induced hangovers using a dissolvable orally administered strip.

Abstract: In accordance with the present invention, iodine, an iodine derivative(s), or a combination of a plurality of these substances is presented as the active ingredient of a stable naturopathic liquid solution. More specifically, in addition to the active ingredient, the naturopathic solution will include a liquid carrier that has been saturated with an inert gas (e.g. Nitrogen) to improve the stability of the active ingredient and increase the shelf life of the solution. For the manufacture of the solution, a liquid carrier (e.g. purified distilled water) is degassed and then subsequently saturated with the inert gas. The active ingredient is then added to the saturated liquid carrier to create the naturopathic liquid solution.

Abstract: An article and process provides a stable technology that reduces the microbial content by providing molecular iodine to the stabilized reagents when at least two reactants are activated by aqueous and/or alcohol materials.

Abstract: The invention provides a topical pharmaceutical composition for application to the nasal or ocular mucosa which comprises (1) a pharmaceutical excipient suitable for topical administration, (2) a mucosal adjuvant, (3) an antihistamine drug and (4) a mast cell stabilizer, a non-steroidal anti-inflammatory drug, a phosphodiesterase inhibitor, an anti-IgE agent, heparin, a topical steroid or a leukotriene blocker.

Abstract: An article is applied to the body of an animal (including humans) to provide both absorbency and antimicrobial activity. The article may comprise a water absorbent material; and a composition that reacts with water to produce molecular iodine. The composition provides a local concentration (in the water) of at least 10 parts per million iodine in water carried by the material (that is actual water supported by the water absorbent material) when the material has 5% by weight of water present in the water absorbent. The article may be a diaper, sanitary pad, bandage, bandaid or wrap for an animal.

Abstract: A controlled release molecular iodine biocide for use in human cavities especially the vaginal, penile canal, nasal passages and rectum. Particles can be functionalized with epithelial cell binding molecules and lymphocyte-binding molecules attached to their surfaces. Half of all the particles can contain pH buffer salts that control pH to between around pH 3.5 to pH 4.5. A second half of the particles can contain Iodide and iodate salts. When pH particles and iodate/iodide particles are bound next to each other, molecular iodine is released in a controlled fashion. Molecular iodine is effective biocide. In an alternate embodiment, there can be two distinct populations of particles, one with epithelial cell binding molecules and one with lymphocyte-binding molecules. Again, half of all the particles can contain a pH buffer and half iodide and iodate salts.

Abstract: The present invention is related to the composition and methods of manufacture of orally-dissolvable, edible films as a vehicle for the non-invasive administration of nitroglycerin and/or other active drugs through the mucosal tissues of the oral cavity. The films include a water soluble film-forming polymer such as pullulan. Methods for producing the films are also disclosed.

Abstract: A composition for dissolving or reducing the viscosity of sputum on a surface of a device includes an effective amount of glycerol and an effective amount of dextran sulfate in a saline solution. The effective amount of glycerol is between about 30-50% and the effective amount of dextran sulfate is between about 10-30%. The composition may further include an antimicrobial agent.

Abstract: A skin dressing comprises a hydrated hydrogel material including a source of lactate ions and a supply of glucose, optionally also including a source of zinc ions and a source of iodide ions. The dressing has beneficial effects on skin.

Abstract: The present invention discloses compositions having particles comprising, inorganic element; one or more active ingredient and optionally a release rate modulating agent, suitable for the delivery of active ingredients to human and animal tissues. The particles are nanoparticles or microparticles or mixtures thereof, made preferably by sol-gel method. The compositions are useful for application to the topical or mucosal surfaces preferably in the form of creams, gels, lotions, dry powders, spray, foam and other suitable forms.

Abstract: Chronic obstructive airway diseases are treated by administering an osmotically active compound such as a salt, sugar, sugar alcohol, or organic osmolyte to the afflicted airway surface. The compound may be administered as a liquid or dry powder aerosol formulation. Diseases that can be treated by the method include cystic fibrosis, chronic bronchitis, and ciliary dyskinesia. The formulations of the invention can also be used in conjunction with other active agents such as bronchodilators, sodium channel blockers, antibiotics, enzymes, or purinoceptor agonists on airway surfaces.

Abstract: Compositions provided according to embodiments of the present invention include an inorganic clay admixed with an iodine-containing substance. Suitable iodine-containing substances include I2 and/or one or more iodine salts. Methods of treating a condition or disorder are provided according to the present invention which include administration of a therapeutically effective amount of a composition including an inorganic clay admixed with an iodine-containing substance to an affected subject. Optionally, the composition is administered in an article of manufacture to the affected area.

Abstract: This invention relates to a veterinary antiseptic solution having three sources of iodine including elemental iodine, iodide salt and iodophor. The solution also includes at least one solvent such as alcohol, glycol or water. The solution is below the threshold concentration for elemental iodine of the List I controlled substances. The elemental iodine offers a rapid kill for bacteria. The iodophor offers lasting antibacterial properties. The iodide salt solubilizes elemental iodine and stabilizes the solution. The antiseptic solution forms a waterproof bandage with active antimicrobial properties when the alcohol dries.

Abstract: The present invention relates in part to a composition comprising a compound of Formula I or Formula II and at least one other antimicrobial agent. The invention also relates in part to a pharmaceutical composition comprising the composition of claim 1 and a pharmaceutically acceptable carrier or excipient. The invention further relates in part to a method of treating a subject with a microbial illness comprising administering to a subject in need thereof the aforementioned pharmaceutical composition. The invention further relates in part to a method of disinfecting a surface comprising administering to the surface the aforementioned a composition. The invention also relates in part to a coating comprising the aforementioned composition.

Abstract: The present invention relates to an anti-bacterial, anti-viral, and anti-fungus composition, its preparation and use. The composition of the present invention mainly includes the following three ingredients in an adequate ratio: (A) a metal compound having catalytic function; (B) ionic compound, and (C) an additive. The anti-bacterial, anti-virus, and anti-fungus composition of the present invention is capable of destroying viruses as well as killing bacterial and fungi. Therefore, the composition can be formulated as an aerosol and a film for applying to protection devices such as respirators, masks, gloves, filters, condoms, etc. The present composition can also be used in household, vehicle, hospital, school, restaurant, hotel, internet coffee shop for applying to filter of air-conditioner, tap, stool, interior of elevator and its keyboard.

Abstract: Animals have been domesticated and kept as a source of milk for tens of thousands of years. When humans keep animals for their ability to produce milk, the animals are usually kept in confined spaces. As a result of this confinement the animals are exposed to high levels of urine and fecal matter which originated with the animals which are being kept. This exposure contaminates the animal and in particular the udder and teats of the animal, with bacteria. In the milking process this bacteria can further contaminate the milk which is destine for human consumption. The bacteria can further cause mastitis in the bovine. The above set forth problems are eliminated in the subject invention wherein the udder and teat areas of the bovine are sanitized with a solution which contains both Cl+ and I+ ions wherein the I+ ion is produced by the oxidation of a solution of a dry iodine salt, without an N-chloro organic compound. The iodine salt may be an alkali metal iodide, an exemplary oxidizer is tricholormelamine.

Abstract: The invention provides a method for treating urinary tract infections in a patient by providing a mouth rinsing composition which releases free molecular iodine into the mucous membranes which enters into the urinary tract.

Abstract: The invention discloses a trace element solution, which comprises at least one metal selected from the group comprising selenium, copper, zinc, manganese and chromium and which comprises a concentration of the metal(s) of at least 60 mg/ml. The solution further comprises at least one compound selected from the group comprising iodine, potassium iodide, sodium iodide, iron, iron chloride, zinc oxide, manganese sulphate, sodium selenite, copper carbonate, sodium carbonate, anhydrous disodium EDTA and sodium hydroxide. The trace element solution is prepared by a method consisting essentially of the steps of preparing a MnCO3 mixture in a container; adding an EDTA/NaOH mixture to the container and subsequently adding at least one metal compound; and adding Na2SeO3 to the container to obtain the trace element solution. The method also comprises the step of adding CrCl3.6H2O to the trace element solution.

Abstract: A teat dip composition comprising from about 0.1% to about 2% iodine by weight of the composition on a formulation basis and form about 45% to about 99.9% propylene glycol by weight of the composition on a formulation basis, and a method of using such composition to treat mastitis.

Abstract: A tablet for oral administration of nutritional indium comprises about 10–50 mg indium sulfate, about 4–20 mg caffeine, about 2–10% by weight cocoa powder, and about 5–10% by weight ethyl cellulose, in combination with about 50–150 ?g of each of zinc oxide, copper (II) oxide, magnesium oxide, potassium iodide, selenium amino acid chelate, chromium amino acid chelate and manganese amino acid chelate.

Abstract: An iodine preparation composition suitable for use on wounds comprising an iodide source, an oxidant and a buffer characterized in that the iodide is held separately from the oxidant until the point of use, and that the buffer is capable of maintaining the pH of the composition at between pH 45 and pH 6 so that iodine is generated at a physiologically acceptable dose rate.

Abstract: There is disclosed a medical device for implantation that acts to prevent transmission of infectious agents. Specifically, the present invention provides implantable devices, such as catheters or living skin matrices or wound dressings, for insertion into various body cavities or over wound sites to confer to the site microbicidal or virucidal activity. Devices in the disclosure designed as vaginal inserts also exhibit contraceptive spermicidal activity. The coated devices or devices having the inventive polymeric material interspersed throughout are formed into appropriate shapes according to their contemplated uses (such as catheters or Foley catheters). Further, the present invention provides devices for providing therapeutic anti-microbial activity into an infected body cavity or on an infected wound site.

Abstract: The invention provides a composition of matter comprising molecular iodine and tetraglycol.

Abstract: Wide spectrum disinfecting and antiseptic composition for use in the fields of human medicine, veterinary science and industry, characterized because it includes: Hydrogen peroxide, lactic acid and halogen salts (Br, I) and/or salts of heavy metals (for example, silver halides) with surfactant agents, either cationic, like chlorhexidine and/or quaternary ammonium salts, like didecyl-methyl-polyoxy-ethyl-ammonium propionate, chlorides of ammonium or compounds of ammonium propylamide or anionic, like lauryl sulphate, dodecyl sulphate or alkyl succinic salts, with suitable excipients, some of which may be ethyl or isopropyl alcohol, chlorhexidine, non-chlorinated quaternary ammonium salts, like didecyl-methyl-polyoxy-ethyl-ammonium propionate, combined or not with iodine, and/or its salts, together with excipients, some of which may be ethyl or isopropyl alcohol.