Abstract: The present invention relates to the use of a polysaccharide selected from the group of non-modified polysaccharides, chemically modified polysaccharides and physically modified polysaccharides, in antiperspirant cosmetic agents, the use of these polysaccharides resulting in an excellent reduction and/or prevention of textile discoloration and/or textile stains.

Abstract: The present invention relates generally to compositions and methods of using compositions comprised of undenatured cartilage in the form of an isolated native Type II collagen that may be combined in a synergistic blend with one or more edible metals with acceptable chemical counter-ions or other health promoting ingredients to be orally consumed as a method for preventing and improving symptoms of musculoskeletal distress degeneration, including symptoms selected from temporary loss of range of motion, temporary inflammation, temporary muscle soreness, and combinations thereof. The synergistic compositions of the present invention also protect, promote and improve recovery from and prevention of cartilage and ligament wear, thinning and damage to bone, and repetitive motion injuries and stress resulting from intense periods of activity or workout routines that contribute to such musculoskeletal distress degeneration symptoms.

Abstract: Methods are provided to make clinoptilolite into a water-soluble hydrolyzed form suitable for various administration routes, including oral administration. Absorption of water-soluble hydrolyzed clinoptilolite fragments can aid in detoxification by binding heavy metals and environmental toxins, can reduce reactive oxygen species and inflammation related to heavy metals and other/environmental toxins, resulting in an increase in energy, and/or in an increase in one or more of focus, concentration, and memory. Water-soluble hydrolyzed clinoptilolite fragments can be combined with one or more dietary supplements, including various vitamins and sleep aids.

Abstract: Prevention or treatment of painful polyneuropathies caused by toxic agents, i.e. to the prevention, reduction or elimination of the symptoms associated with such polyneuropathies, such as neuropathic pain are disclosed. An aluminosilicate for use in such prevention or treatment, preferably a natural or synthetic zeolite, such as clinoptilolite, is provided. The toxic agent is, in particular, a chemotherapeutic cytotoxic agent.

Abstract: A topical composition comprises a clay material with a negative surface charge; magnesium ions and calcium ions; water and/or a non-aqueous solvent; and a substantially non-cationic carrier. The mean particle size of the clay material is at least 5 nm, and the total molar amount of magnesium ions is higher than the total molar amount of calcium ions. The composition is suitable for the prophylaxis and treatment of skin diseases, skin conditions, or mucosal diseases.

Abstract: The present invention generally relates to methods of treating hypertension (HTN) in patients in need thereof wherein the patient optionally further suffers from chronic kidney disease (CKD) or Type II diabetes mellitus (T2DM). The invention also relates to methods of treating hyperkalemia in a patient in need thereof, wherein the patient suffers from CKD, T2DM or HTN and are optionally being treated with an effective amount of a renin-angiotensin-aldosterone system (RAAS) agent. The invention also relates to methods of treating kidney disease in a patient in need thereof, wherein the patient is optionally being treated with an effective amount of a renin-angiotensin-aldosterone system (RAAS) agent. The methods can comprise administering an effective amount of a potassium-binding agent to the patient to lower the patient's blood pressure and/or increase or stabilize the patient's kidney function.

Abstract: A preservative and additive for food and feed. One aspect of the invention concerns various acidified clays and minerals as food or feed additive to kill, or inhibit the growth of, harmful microorganisms and to inactivate mycotoxins, such as aflatoxins, present as contaminants in human foods and animal feeds. Another aspect of the present invention relates to a clay of hydrated sodium calcium aluminosilicate with relatively uniform particle size distribution.

Abstract: The present disclosure relates generally to the field of mucositis. More particularly, methods and compositions for treating, ameliorating and/or preventing mucositis are provided by administering a clay to the subject in need.

Abstract: Compositions that include a clay such as kaolin dispersed in a liquid such as water may be useful for promoting the clotting of blood. The compositions may be in a liquid, gel, paste, foam, or another form. Uses may include treating a traumatic injury such as in injury caused by a bullet, an explosive, a blade etc., or an injury caused during a medical procedure such as surgery.

Abstract: Hemostatic compositions comprising a wet layered clay (e.g., wet kaolin) and, optionally, a zeolite, as well as devices and methods of use to promote blood clotting, are provided.

Abstract: Methods of fabricating implantable medical devices, preferably with PEEK, having antimicrobial properties, are disclosed. The antimicrobial effect is produced by incorporating ceramic particles containing antimicrobial metal cations into molten PEEK resin, which is subsequently allowed to cool and set in its final shape achieved by injection molding, cutting and machining or other techniques.

Abstract: Methods of fabricating implantable medical devices, preferably with PEEK, having antimicrobial properties, are disclosed. The antimicrobial effect is produced by incorporating ceramic particles containing antimicrobial metal cations into molten PEEK resin, which is subsequently allowed to cool and set in its final shape achieved by injection molding, cutting and machining or other techniques.

Abstract: The present invention utilizes a nano-coating of an oxide such as silica, a silicate or another effective oxide on a surface to accelerate blood clotting in mammalian animals. The hemostatic layer has a thickness that is effective for the hemostasis, yet can be made thin enough to result in a resorbable film which can either be applied to a biocompatible or resorbable device that can be used in surgical applications as well as in topical applications such as trauma.

Abstract: The present invention relates to a personal care composition that contains a rinse-off composition which deposits at least 0.5 ?g/cm2 of shiny particles on the skin. Preferably, the shiny particles are hydrophobically modified interference pigments. The inventors have found that hydrophobically modifying the particles significantly improves the deposition of the particles on skin from rinsable compositions.

Abstract: The invention relates to a microbial biomass composition produced from a heterotrophic fermentation whose fatty acid profile exhibits: an eicosapentaenoic acid (EPA) to arachidonic acid (ARA) ratio of about 11:1 or more; an EPA to total co-concentrating fatty acid ratio of about 8:1 or more, extract compositions, and methods of producing such compositions.

Abstract: The invention is for a method of potentiating clinoptilolite, the method including the steps of: providing fresh or spent clinoptilolite; exposing the clinoptilolite to a saline solution having a sodium ion content of about 10% to liberate impurities from the clinoptilolite; and drying the washed clinoptilolite fraction to render a potentiated clinoptilolite fraction. Preferably, the clinoptilolite is exposed to the saline solution for a period of about 48 hours. The washed clinoptilolite may be dried by filtered, heated air. This allows an optimal cation exchange capacity of the clinoptilolite to be reached. The clinoptilolite has uses as a medicament for a variety of aliments.

Abstract: There is described zeolites containing releasably adsorbed nitric oxide, methods of preparing the zeolites, methods of releasing the nitric oxide into a solution or into air and uses of the zeolites in therapy.

Abstract: The present invention relates to a combination of an anti-toxin, The present invention relates to a combination of an anti-toxin, an immunomodulator and a component that provides energy to mucosal cells, which may be useful for decreasing effects of Clostridia sp.

Abstract: The present invention relates to a new class of anitoxidant agent comprising a pharmaceutically acceptable silicate, resveratrol, grape seeds extract, green tea extract and tomato powder. In particular this composition comprises between 32 to 60 percent by weight of a pharmaceutically acceptable silicate, between 6 to 22 percent by weight of resveratrol, between 16 to 20 percent by weight of grape seeds extract, between 8 to 10 percent by weight of green tea extract, and between 10 to 16 percent by weight of tomato powder.

Abstract: Nanocomposite compositions forming mixed clathrates and methods for using such compositions for entrapping guest moieties such as malodors, molds and cells are disclosed.

Abstract: The invention relates to the prevention or treatment of painful polyneuropathies caused by toxic agents, i.e. to the prevention, reduction or elimination of the symptoms associated with such polyneuropathies, such as neuropathic pain. The invention provides an aluminosilicate for use in such prevention or treatment, preferably a natural or synthetic zeolite, such as clinoptilolite. The toxic agent is, in particular, a chemotherapeutic cytotoxic agent.

Abstract: The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.

Abstract: The invention provides a process for producing a composition comprising natural alumino-silicate minerals having improved reactivity for use in methods of animal husbandry, veterinary and pharmaceutical treatment, comprising irradiating natural alumino-silicate minerals in a liquid suspension with transverse electromagnetic wave radiation in the range of 1,800 MHz to 3,000 MHz, the liquid suspension having a boiling temperature of below 120° C. The invention also provides a method of treating digestive ailments in animals comprising administering to an animal in need of same an effective amount of a composition comprising at least one natural alumina-silicate mineral which has been irradiated with transverse electromagnetic wave radiation in the range of 1,800 MHz to 3,000 MHz.

Abstract: The present invention provides a composition comprising functional mineral that is substantially free of crystalline silica. The agricultural particle film composition may be applied to horticultural plants and animals.

Abstract: Hemostatic devices for promoting blood clotting can include a substrate (e.g., gauze, textile, sponge, sponge matrix, one or more fibers, etc.), a hemostatic material disposed thereon such as kaolin clay, and a binder material such as crosslinked calcium alginate with a high guluronate monomer molar percentage disposed on the substrate to substantially retain the hemostatic material material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood to accelerate clotting. Moreover, when exposed to blood, the binder has low solubility and retains a majority of the clay material on the gauze. A bandage that can be applied to a bleeding wound to promote blood clotting includes a flexible substrate and a gauze substrate mounted thereon.

Abstract: The present invention relates to hemostatic compositions comprising a mesocellular oxide foam and, optionally, a biologically active agent such as a procoagulant, as well as devices and methods of use to promote blood clotting.

Abstract: The present invention provides compositions comprising silicon and at least one other joint health ingredient such as glucosamine, chondroitin, hyaluronic acid, collage, etc. as well as methods for making and using the same.

Abstract: The present disclosure relates to the preparation of a polymer composite material for building air conditioning or dehumidification having superior water-adsorbing ability, durability and antibacterial properties by electro spinning. Specifically, the disclosed method for preparing a polymer composite material for building air conditioning or dehumidification includes: (S1) adding a crosslinking agent or a crosslinking agent and a porous filler for conferring durability and antibacterial properties into a hydrophilic polymer solution antibacterial properties to prepare a polymer composite material solution; (S2) electrospinning the polymer composite material solution to prepare a nanofiber sheet; and (S3) crosslinking the nanofiber sheet by heat-treatment.

Abstract: The present invention herein provides antibacterial zeolite particles whose ion-exchangeable ions have completely or partially been replaced with silver ions and zinc ions, wherein the ratio (A/B) of the silver ion concentration (A) to the zinc ion concentration (B) in the antibacterial zeolite particles increases in the direction along the depth of each zeolite particle. The antibacterial zeolite particles show excellent discoloration-resistant characteristics, while maintaining their excellent antibacterial activities. Accordingly, the antibacterial zeolite particles can suitably be applied to all sorts of products that are required to have antibacterial properties.

Abstract: An adjuvant composition is provided which comprises: (a) at least one water-soluble electrolyte; (b) at least one electrolyte-tolerant surfactant; (c) antifoam component which is at least one mixture selected from the group consisting of (1) at least one branched silicone resin (i), at least one silicone fluid (ii), at least one particulate metal oxide (iii) and, optionally, at least one catalyst (iv) for catalyzing the condensation of siloxy groups, (2) the equilibration reaction product of mixture (1), and (3) mixture (1) in which at least a portion of particulate metal oxide (iii) is pre-hydrophobized; (d) optionally, at least one additional bioinert material; and, (e) water.

Abstract: The present invention relates to the preparation of zeolites obtained with a method comprising a stage of heating to temperature preferably of over 400° C. and at least one stage of micronisation. Such zeolites are to be used in the pharmaceutical sector, in particular to combat the action of ROS at a mitochondrial level with a neuroprotective effect.

Abstract: The present invention relates to methods useful for treating and/or preventing mucositis using an active vitamin D compound.

Abstract: The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices. The intrinsic bioactivity of the hydrogel matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implanted device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissue bulking.

Abstract: The present disclosure relates generally to the field of oral mucositis. More particularly, methods and compositions for treating, ameliorating and/or preventing oral mucositis are provided. Methods and compositions for treating, ameliorating and/or preventing oral mucositis are also provided.

Abstract: A hemostatic agent composition that includes a clay hemostatic agent which is inert and non-reactive relative to blood clotting proteins and platelets, yet is capable of accelerating the formation of a stable clot when applied to an actively bleeding wound.

Abstract: The present invention relates to liquid or semi-solid pharmaceutical compositions, more specifically to aqueous pharmaceutical suspension or semi-solid paste containing natural mineral clays as active ingredients. These compositions are particularly useful for the treatment of acute and chronic diarrhea.

Abstract: Compositions, kits and methods of preparing a biocompatible film for cosmetic or medical uses are disclosed. The compositions or kits contain polyvinyl acetal (PVA), siloxane and a solvent. The siloxane can have a hydrophilic group. Once the solvent content is reduced, for instance, by evaporation, the mixture of PVA and siloxane is solidified, forming a film. The compositions and kits, optionally, further include one or more of an antimicrobial agent, a pigment, an anti-inflammatory agent, an anesthetic agent or a hemostatic agent. Such a film can be used, for example, in the form of an antimicrobial sealant, a liquid bandage, body paints, scar camouflage, water-proof sun block, makeup sealer, or antimicrobial wipe or spray.

Abstract: Compositions which deliver adsorbents, alone or in combination with active drug “degrading molecules,” in a site-specific manner to the intestine, and which eliminate or at least lower the concentration of residual unwanted material within the intestine, and methods of treatment using the compositions, are disclosed. The compositions are ideally designed to specifically release the adsorbents in a programmed manner at a specific site of the intestinal tract. Programmed delivery prevents adsorbents from interfering with the normal absorption process of a given molecule after oral absorption, until it reaches the lower part of the small intestine. The compositions can be used to adsorb, and therefore remove, any residual drug, metabolite thereof, or bacterial toxin after oral or parenteral administration which would otherwise cause adverse effects in the lower intestine and/or colon.

Abstract: The invention relates to the use of a clay for the preparation of a medicament for treating coeliac disease. Preferably, the clay used is of smectite type.

Abstract: Methods of fabricating implantable medical devices, preferably with PEEK, having antimicrobial properties, are disclosed. The antimicrobial effect is produced by incorporating ceramic particles containing antimicrobial metal cations into molten PEEK resin, which is subsequently allowed to cool and set in its final shape achieved by injection molding, cutting and machining or other techniques.

Abstract: Glycopyrronium bromide, derivatives and/or isomers thereof in combination with one or more active substances selected from a list of substances as recited in the claims and/or in the form of a W/Si emulsion, an O/W gel, a soap gel stick, and/or a surfactant-containing cleansing formula, and corresponding cosmetic preparations, in particular deodorant/antiperspirant preparations.

Abstract: A low heavy metal (i.e. cadmium, mercury) containing calcium aluminum silicate product produced by the method of Air Classification. The method comprises using an air classification system for separating a cadmium containing calcium aluminum silicate feed stock into at least a first fraction and a second fraction. The first separation fraction contains material having an average particle size over 100 um, and the second fraction contains material having an average particle size under 100 um.

Abstract: A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.

Abstract: Provided are pharmaceutical compositions for the treatment or prophylaxis of the gastrointestinal tract. One of the pharmaceutical composition includes co-particles of an adsorbent, and one or more carbohydrates. This pharmaceutical composition may be used, for example, in the treatment or prophylaxis of diarrhea, for adsorbing digestive tract microorganisms, for enhancing weight gain, or for enhancing milk production in a mammal. Another pharmaceutical composition can include one or more enzymes and a pH buffer system, wherein the pH buffer system causes an alkalinization of at least a portion of a gastrointestinal tract. This pharmaceutical composition may be used, for example, for increasing milk production in a mammal.

Abstract: The present invention relates to compositions and methods for deterring and repelling all types of organisms capable of sensing electric or magnetic fields, including insects and arachnids. The compositions contain electrically or magnetically imprintable substances comprising an electric or magnetic charge or imprint, wherein the imprint contains the signature of at least one target organism; and an acceptable carrier.

Abstract: Compositions comprising clay minerals and methods for their use in promoting hemostasis are provided. The compositions comprise clay minerals such as bentonite, and facilitate blood clotting when applied to a hemorrhaging wound. Electrospun or electrosprayed materials (e.g. bandages, micron beads, etc.) which include clay minerals, and methods for the treatment of acute hemorrhage, are also provided.

Abstract: A composition for promoting the formation of clots in blood comprises a zeolite and a binder. The zeolite is adjusted to have a specific moisture content. Processes by which the moisture content is adjusted include drying, re-hydrating, and combinations of drying and re-hydrating. A method of forming the composition comprises the steps of providing a zeolite and adjusting the moisture content such that upon application of the composition to a wound, a heat of hydration is reduced and heat transferred to the wound is reduced. A method of clotting blood flowing from a wound comprises the steps of applying the zeolite to the wound and maintaining the zeolite in contact with the wound for a predetermined amount of time, the zeolite having an adjusted moisture content and being capable of producing a controllable exothermic effect on the wound.

Abstract: A method for producing a complex of metallic nanoparticles and inorganic clay and an organic promoter, wherein the organic promoter is ethanolamine, for example, monoethanolamine (MEA), diethanolamine (DEA) or triethanolamine (TEA). The metallic nanoparticles produced by this method can be stably and uniformly dispersed without adding other reducing agent or dispersant.

Abstract: The present invention provides a W/O emulsion cosmetic excellent in the feeling in use and stability. The W/O emulsion cosmetic of the present invention comprises the following components (A) to (F): (A) 0.1 to 5 mass % of polyoxyalkylene/alkyl-comodified silicone; (B) polyoxyalkylene-modified silicone, being 0.2 to 3 times in mass with respect to the component (A); (C) 5 to 50 mass % of powder; (D) 10 to 50 mass % of a volatile oil; (E) 1 to 20 mass % of ethanol; and (F) water. In addition, the dispersion stability of powder and viscosity stability of the composition can be improved, by further blending sodium glutamate or by further blending an organically modified clay mineral and diglyceryl diisostearate therein. Furthermore, if glycerin and a specific nonvolatile oil are blended therein, the moisturizing property can be improved.

Abstract: The invention relates to the production of a clay-impregnated substrate (10), including a step in which a pasty material (3), containing clay mixed with a liquid, is sprayed onto a substrate (1) having an aerated structure.