Aluminum Silicate Patents (Class 424/684)
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Patent number: 5490985Abstract: An antacid product having extended duration of residence in the gastric and upper intestinal systems has been developed. This antacid product includes a blend of 10-70% by volume nonphospholipid lipid vesicles, with a particulate base. An antiflatulence agent may also be included. A method of providing extended duration amelioration of acid build up in the gastric and upper intestinal tract using this product is also disclosed.Type: GrantFiled: March 18, 1994Date of Patent: February 13, 1996Assignee: Micro-Pak, Inc.Inventors: Donald F. H. Wallach, Rajiv Mathur, Jean Philippot, Surendra Kumar
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Patent number: 5455050Abstract: The present invention relates to an aqueous pharmaceutical suspension for oral use, and a method of preparation, having antacid and antiulcer properties which contains a therapeutically effective amount of calcium carbonate in combination with magnesium carbonate and/or magnesium trisilicate and a carboxylic acid pH adjusting agent.Type: GrantFiled: November 12, 1993Date of Patent: October 3, 1995Assignee: McNeil-PPC, Inc.Inventors: Douglas S. Beyerle, Gerard P. McNally
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Patent number: 5429814Abstract: The invention relates to a method of using molecular sieve-enclosed paramagnetic ions as image brightening or image contrast agents. In particular, zeolite enclosed trivalent gadolinium is useful in MRI studies of the entire gastrointestinal tract, providing excellent images. Zeolite-enclosed gadolinium complexes may be conveniently administered in oral preparations without side effects of diarrhea. Other transition metal ions, including divalent manganese may be enclosed in any suitable molecular sieve which has ion exchange properties sufficient to exchange the selected metal. The exchanged paramagnetic metal ion may be a free ion within the zeolite framework or ligated with a chelator. Alternatively, a paramagnetic metal ion may be included as part of the molecular sieve framework.Type: GrantFiled: May 27, 1993Date of Patent: July 4, 1995Assignee: Board of Regents, The University of Texas SystemInventors: Stuart W. Young, Kenneth J. Balkus, Jr., A. Dean Sherry
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Patent number: 5424142Abstract: A negative contrast agent for MRI is an aqueous suspension having a quantity of barium sulfate between 25 and 30 percent by weight and a quantity of bentonite between 2.5 and 3.5 percent by weight and between 0.15 and 0.25 mM Fe as a ferrite. Such a negative contrast agent provides substantially black imaging in a T2 weighted pulse sequence; namely a relative signal intensity (RSI) of near zero. It also provides a relative signal intensity (RSI) of well under 10 percent of that of water in a T1 weighted pulse sequence.Type: GrantFiled: May 20, 1993Date of Patent: June 13, 1995Assignee: E-Z-EM, Inc.Inventor: Michael A. Davis
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Patent number: 5326564Abstract: A cosmetic product is provided that includes a cosmetic composition and a container for storing same. The container has a first and second section. Each section is defined by a hemispheroidal chamber having an open mouth with a circumferential edge therearound and a flange projecting outwardly therefrom. The first section contains the cosmetic composition and is sealed by a web completely covering the mouth as well as the flange. On the flange of the second section is a lip with a clamping device for releasably engaging the first section flange thereby releasably joining first and second sections to one another.Type: GrantFiled: November 25, 1992Date of Patent: July 5, 1994Assignee: Elizabeth Arden Co., Division of Conopco, Inc.Inventors: Joseph LaRosa, John Vaccaro, Victoria Connell
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Patent number: 5320843Abstract: A method for improving the antibacterial efficacy of an ophthalmic solution, particularly a solution for the care of contact lenses, comprises providing an article molded from a plastic resin including an inorganic carrier retaining antibacterial metal ions, and placing the ophthalmic solution in contact with the plastic resin.Type: GrantFiled: December 10, 1992Date of Patent: June 14, 1994Assignee: Polymer Technology CorporationInventors: Manohar K. Raheja, Stanley J. Wrobel
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Patent number: 5314700Abstract: New methods and feed compositions are disclosed for enhancing the reduction of coccidial-induced intestinal lesions in poultry and for enhancing shank pigmentation in poultry. Such methods comprise coadministering zeolite and coccidiostats, such as in a feed mixture or by separate administration.Type: GrantFiled: January 28, 1991Date of Patent: May 24, 1994Assignee: Ethyl CorporationInventors: Dewey G. Barnes, Sebastian M. Laurent
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Patent number: 5298252Abstract: A silica gel based heat-resistant and weatherproof antimicrobial composition having an aluminosilicate layer on the surfaces of pores in the silica gel as substituted by silver and an optional antimicrobial metal, said composition containing ion-exchangeable metals that are chiefly an alkali metal and that are present in an amount of up to 2.57 mmol per gram of said composition on an anhydrous basis.Type: GrantFiled: August 29, 1991Date of Patent: March 29, 1994Assignees: Hagiwara Research Corp., Japan Electronic Materials CorporationInventors: Zenji Hagiwara, Masao Okubo
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Patent number: 5298222Abstract: A process for treating musculoskeletal tissue which comprises contacting musculoskeletal tissue with both an effective amount of at least one treating agent selected from the class consisting of antibiotics and disinfectants, and an agent to increase diffusion of the treating agent into the tissue, such as a surfactant or a permeation enhancer. The disinfectant and/or antibiotic function in killing bacteria, vegetative organisms, and viruses (including HIV virus) which may be remaining in the musculoskeletal tissue. A preferred disinfectant is ethanol.Type: GrantFiled: August 9, 1989Date of Patent: March 29, 1994Assignee: Osteotech, Inc.Inventor: Robert K. O'Leary
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Patent number: 5288507Abstract: This invention relates to a pharmaceutical composition for use in the treatment of pain and inflammation and the treatment of acid indigestion, sour stomach, heartburn and symptoms of upset stomach associated with these conditions in a mammalian organism, said composition comprising:(i) an analgesically and anti-inflammatory effective amount of (S)-ibuprofen, or a salt thereof, substantially free of (R)-ibuprofen;(ii) an amount effective in the treatment of acid indigestion, sour stomach and/or heartburn of at least one of the antacids; and(iii) optionally, an amount effective in treating excess gas and flatulence of an anti-gas agent.Type: GrantFiled: July 29, 1992Date of Patent: February 22, 1994Assignees: Merck & Co., Inc., McNeill-PPC, Inc.Inventors: Robert T. Sims, Thomas N. Gates, William Slivka
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Patent number: 5264225Abstract: The invention relates to an environment-protective agent consisting of silicon-containing minerals for adsorbing radiactive metal isotopes and toxic heavy metals, which comprises as silicon-containing minerals with a particle size of 0.001 to 0.5 mm; a natural diatomaceous earth and at least two natural zeolite minerals of the general formulaM.sub.x O.Al.sub.2 O.sub.3.YSiO.sub.2.7H.sub.2 OwhereinM stands for sodium, potassium or calcium;x is a number between 1 and 2 inclusive of both extreme values;Y is 3 or 10; andZ is 6 or 7treated by dilute acid, washed to neutral, dried to a constant weight at a temperature up to 115.degree.0 C. and then heat-treated at 150.degree. to 350.degree. C., preferably at 250.degree. C., where the amount of each mineral ingredient independently of each other is at least 0.1% by weight up to 99.8% by weight calculated to the total weight of the agent.Type: GrantFiled: December 20, 1990Date of Patent: November 23, 1993Assignees: Argomen Agrarmenedzseri Kft., Orszagos "Frederic Joliot-Curie" Sugarbiologiai es Sugar-Egeszsegugyi Kutato Intezet, Magyar Kulkereskedelmi Bank Rt.Inventors: Laszlo Varga, Mihaly Torocsik, Balint L. Sztanyik
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Patent number: 5252345Abstract: A composition containing a zeolite and an acid suitable for use in increasing bone strength in an animal having a bone strength less than desired and/or for use in treating, preventing or delaying the onset of a bone disorder such as osteoporosis, osteochondrosis, or dyschondroplasia. A preferred zeolite is zeolite A. Preferred acids are illustrated by citric, fumaric and aspartic acids. The presence of such acids in the composition enhances the breakdown (i.e. decomposition) of the zeolite thereby making it more efficacious for increasing bone strength or combating bone disease. Preferably, the compositions contain from about 35 to about 65 weight percent of the acid; the remainder being the zeolite Such compositions can be admixed with other materials such as excipients used in the preparation of unit dosage forms.Type: GrantFiled: February 1, 1991Date of Patent: October 12, 1993Assignee: Ethyl CorporationInventors: Patrick C. Hu, James S. Staton, Karl E. Wiegand
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Patent number: 5211870Abstract: A malodor-free personal cleansing bar with a low level of zeolite odor-controlling agent. The preferred application is a fragrance-free bar, a scented bar, or the like.Type: GrantFiled: March 11, 1992Date of Patent: May 18, 1993Assignee: The Procter & Gamble CompanyInventors: Lawrence A. Gilbert, Danielle L. Fieldstad, Sherri V. Cox, Diane L. Furio, Wayne E. Eccard, Neil W. Jordan
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Patent number: 5173305Abstract: A pharmaceutical composition is provided for the protection of the oesogastroduodenal mucous membrane, which composition has an active antacid component comprising sufficient guar gum to provide antacid and buffering effect at a pH of from 0.8 to 3.5, and at least one antacid agent other than guar gum in an amount effective as an antacid.Type: GrantFiled: February 22, 1990Date of Patent: December 22, 1992Inventor: Georges S. Grimberg
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Patent number: 5140949Abstract: A hydrous aluminosilicate adsorbent composition in which the active adsorbent is a mixture of non-fibrous clay with non-fibrous zeolite. The composition is useful as a feed supplement in animal husbandry, and as a topical adsorbent for veterinary use. The mixture has a high capacity for adsorption of ammonium cations, and a synergistically high selectivity for their adsorption. Beneficial effects as feed supplement may arise from lowering the amount of ammonia passed to the liver from the alimentary canal.Type: GrantFiled: September 12, 1991Date of Patent: August 25, 1992Assignee: Mobil Oil CorporationInventors: Pochen Chu, William E. Garwood
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Patent number: 5139782Abstract: A composition for the cosmetic treatment of human skin, particularly facial skin, to remove retention products from the skin surface and sebaceous follicles, is disclosed. The composition comprises a high-silica zeolite, the principal adsorbent constituent, dispersed in an aqueous medium using colloidal hectorite-type clays, a water soluble alkyl polyol preferably having from 2 to 6 hydroxyl groups, and most preferably a glycol such as propylene glycol, and an anti-microbial agent compatible with the high-silica zeolite.Type: GrantFiled: December 23, 1991Date of Patent: August 18, 1992Assignee: UOPInventor: Mary L. Jung
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Patent number: 5122363Abstract: The invention relates to a method of using zeolite enclosed paramagnetic ions as image brightening or image contrast agents. In particular, zeolite enclosed trivalent gadolinium is useful in MRI studies of the entire gastrointestinal tract, providing excellent images. Zeolite-enclosed gadolinium complexes may be conveniently administered in oral preparations without side effects of diarrhea. Other transition metal ions, including divalent manganese may be enclosed in any suitable zeolite which has ion exchange properties sufficient to exchange the selected metal.Type: GrantFiled: December 7, 1990Date of Patent: June 16, 1992Assignee: Board of Regents, The University of Texas SystemInventors: Kenneth J. Balkus, Jr., A. Dean Sherry, Stuart W. Young
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Patent number: 5093134Abstract: Compounds of the formula,A.sub.x [D'(MW.sub.11 O.sub.39).sub.2 ].multidot.yH.sub.2 Oin which A is a cation, x is an integer, M is B, Si or P, D is metal and D' is a lanthanide in oxidation state 3 or 4, L is a neutral or anionic ligand, and y is an interger, have anti-viral activity in a standard screen, and may be used to produce compositions and also coated articles and devices for treatment or prophylactic treatment of patients at risk.Type: GrantFiled: March 14, 1990Date of Patent: March 3, 1992Assignee: Johnson Matthey Public Limited CompanyInventors: Barry A. Murrer, Brian R. C. Theobald, Paul D. Savage
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Patent number: 5082662Abstract: Methods of (a) improving the quality of the bones and/or increasing the bone strength and/or the blood quality of and/or (b) treating ascites and/or fatty liver syndrome in animals, including humans, cattle, sheep, goats, swine, cats, dogs and poultry without deleterious effects on the animals or products of the animals by adding small effective amounts of zeolite to the feed of the animals or directly to the animals in the form of a capsule, tablet or the like.Type: GrantFiled: October 17, 1990Date of Patent: January 21, 1992Assignee: Ethyl CorporationInventors: Sebastian M. Laurent, Robert N. Sanders
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Patent number: 5037648Abstract: A skin conditioning composition in the form of a lotion applied to the skin has bicarbonate ions in an emollient carrier and pH in excess of 7.0. The composition is formed by the combining of a diluent with thickener/stabilizer and a hemectant with a fat agent and emulsifier which brings the pH to 7.0 and above 7.0 to which is added an aqueous solution of sodium bicarbonate. A quantity of mineral oil which serves as an emollient is a preferred addition to the final mixture.Type: GrantFiled: January 22, 1990Date of Patent: August 6, 1991Inventor: Evelyn S. Joiner
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Patent number: 4978536Abstract: Disclosed is use of a synthetic aluminum silicate as antacid and anti-ulcer preparation, anti-obesity preparation and acne curing preparation. This aluminum silicate is obtained by reacting an aluminum compound and silicic acid or water glass at a weight ratio Al.sub.2 O.sub.3 : SiO.sub.2 of 4.5:1.0-6.0:1.0 in a strongly acidic aqueous solution having an initial pH of 1.0-3.0, then adding thereto a basic substance to reach excess in alkali and then neutralizing the reaction mixture to pH 5.0-7.0 with an acid.Type: GrantFiled: May 17, 1988Date of Patent: December 18, 1990Assignee: Yakurigaku Chuo KenkyushoInventor: Hidehiko Takahashi
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Patent number: 4970080Abstract: Methods of (a) improving the quality of the bones and/or increasing the bone strength and/or the blood quality of and/or (b) treating ascites and/or fatty liver syndrome in animals, including humans, cattle, sheep, goats, swine, cats, dogs and poultry without deleterious effects on the animals or products of the animals by adding small effective amounts of zeolite to the feed of the animals or directly to the animals in the form of a capsule, tablet or the like.Type: GrantFiled: January 30, 1939Date of Patent: November 13, 1990Assignee: Ethyl CorporationInventors: Sebastian M. Laurent, Robert N. Sanders
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Patent number: 4942042Abstract: An anti-diarrhea composition comprises diarrhea symptom-reducing amounts of a powdered absorptive material capable of absorbing pathogenic intestinal bacteria, a sodium salt, a potassium salt and a sugar. The absorptive material may be Smectite or mormoiron attapulgite. The salts are preferably NaCl and KCl, with NaHCO.sub.3 also being present. Suitable sugars are glucose and dextrose. The composition may also contain a suspending agent, a coloring agent, a flavoring agent and a sweetening agent. It may be packaged in solid form for admixture with water prior to administration and is preferably moisture protected, for example by the nature of the packaging or by inclusion of a dessicant. The absorptive material may be packaged separately from the salts and sugar. On admixture with water for adminstration, the composition preferably contains, per liter, 2.5 to 15 g of absorptive material, 10 to 30 g of glucose, 60 to 120 mEq of Na.sup.+, 10 to 50 mEq of HCO.sup.- and 10 to 30 mEq of K.sup.+.Type: GrantFiled: August 29, 1988Date of Patent: July 17, 1990Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S. C. A. S.)Inventors: Hridaya Bhargava, Jacques Jutteau
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Patent number: 4911899Abstract: Zeolite particles retaining at least one metal ion having bacteriostatic properties on their ion-exchangeable sites in an amount up to 41% of the zeolite's ion exchange capacity are described.Type: GrantFiled: December 28, 1988Date of Patent: March 27, 1990Assignees: Kanebo Limited, Zenji HagiwaraInventors: Zenji Hagiwara, Shigetaka Hoshino, Hiroo Ishino, Saburo Nohara, Kenichi Tagawa, Keio Yamanaka
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Patent number: 4877601Abstract: Use of a physiologically inert hydrophobic molecular sieve material to lower the blood alcohol level in the human body in the form of an edible composition or a suppository, the material having a pore size permitting the absorption of ethanol but preventing the absorption of larger molecules with lipophilic character. The material may be a crystalline zeolitic material such as Silicalite or ZSM5.Type: GrantFiled: February 18, 1987Date of Patent: October 31, 1989Assignee: Watney Combe Reid & Truman LimitedInventor: John J. Wren
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Patent number: 4847085Abstract: A method of improving the quality of the bones and/or increasing the bone strength of aminals, including humans, cattle, sheet, goats, swine and poultry without deleterious effects on the animals or products of the animals by adding a small effective amount of zeolite to the feed of the animals or directly to the animals in the form of a capsule, tablet or the like.Type: GrantFiled: November 25, 1985Date of Patent: July 11, 1989Assignee: Ethyl CorporationInventors: Sebastian M. Laurent, Robert N. Sanders