Carbonate Or Bicarbonate Patents (Class 424/686)
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Patent number: 6024985Abstract: The invention provides a synthetic bone precursor material comprising amorphous calcium phosphate and a constituent that inhibits the crystallisation of calcium hydroxyapatite to amorphous calcium phosphate. The synthetic bone precursor may comprise a material of formula CaxMgyPO4 wherein Mg acts as an inhibitor for crystallisation. Other crystallisation inhibitors such as pyrophosphate may be present. The inhibitor is capable of dissolving in physiological saline. Loss of inhibitor from the precursor allows crystallisation of hydroxyapatite. The invention relates to use of a synthetic bone precursor to form bone in vivo, by a transformation of the amorphous precursor material to crystalline hydroxyapatite bone material by the leaching action on inhibitory ions body fluids. it is envisaged that the material will be useful in facilitating bone repair, inducing bone formation or assisting in the attachment of prostheses.Type: GrantFiled: April 5, 1995Date of Patent: February 15, 2000Assignee: University of ReadingInventors: Kenneth Simkiss, Marina Gloria Taylor
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Patent number: 5976578Abstract: Liquid antacid compositions containing a tri- or di-ester buffer have a reduced final product pH providing for a more efficacious preservative system and better tasting product without compromising to acid neutralization capacity of the antacid.Type: GrantFiled: September 17, 1997Date of Patent: November 2, 1999Assignee: McNeil-PPC, Inc.Inventors: Douglas S. Beyerle, John Case, Gerard P. McNally, Frank Hatch
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Patent number: 5958464Abstract: A composition for preventing and treating milk fever in freshening cows, and a method of administering the composition. The basic composition is a mixture of water, calcium chloride, propylene glycol, B vitamins and minerals. The calcium content is lower than conventional calcium treatments used for this purpose. The propylene glycol gives the cow an energy boost and sweetens the taste so the cow does not object to it as it does to conventional gels and liquids. The B vitamins stimulate the cow's appetite. The minerals replace minerals lost in the milk and also help the cow absorb calcium. The composition of the present invention is in a liquid form and is preferably administered using a 200-300 cc drench gun. The end of the dispensing tube of the drench gun is placed between the teeth and cheek of the cow near the receptors that stimulate the esophageal groove reflex.Type: GrantFiled: November 12, 1997Date of Patent: September 28, 1999Inventor: Jack W. Register
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Patent number: 5945129Abstract: The invention relates to a process for the production of an infusion or dialysis solution containing bicarbonate and having a physiologically tolerable pH. In order to retain a solution with a stable physiologically tolerable pH even after heat treatment for sterilization, according to the invention, at least 2 mmol/L of at least one carboxylic acid ester is introduced into the solution beforehand. The solution is subjected to heat treatment above 100.degree. C., so that the carboxylic acid ester decomposes almost completely into carboxylic acid and alcohol. The invention further relates to a use of the process according to the invention for the production of a solution for peritoneal dialysis and a medicinal infusion or dialysis solution.Type: GrantFiled: August 1, 1997Date of Patent: August 31, 1999Assignee: Fesenius Medical Care Deutschland GmbHInventors: Thomas Knerr, Thomas Wild
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Patent number: 5942255Abstract: The invention is directed to a method of enhancing lean tissue mass in a subject by administering calcium to the subject, thereby enhancing the lean tissue mass in the subject. The invention is also directed to a method of enhancing bone mineral content in a physically active subject comprising administering calcium to the subject, thereby enhancing the bone mineral content in the subject. The invention is also directed to a method of enhancing bone mineral content and of enhancing lean tissue mass in a subject comprising administering calcium to the subject, thereby enhancing the bone mineral content and enhancing the lean tissue mass in the subject. The invention is further directed to a milk-free composition for enhancing bone mineral content and/or for enhancing lean tissue mass in a physically active subject, comprising an effective amount of calcium.Type: GrantFiled: July 15, 1996Date of Patent: August 24, 1999Assignee: The University of MemphisInventor: Robert C. Klesges
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Patent number: 5935610Abstract: A pharmaceutical composition having buffering properties comprises as its primary ingredients calcium carbonate (CaCO.sub.3) and magnesium oxide (MgO; magnesia) that form the base for the compound. Potassium sorbate (CH.sub.3 CH: CHCH:CHCOOK) is provided as a preservative. Other ingredients include a tabletizing binder, vitamin complexes, minerals as antipathogens, and flavorings.Type: GrantFiled: March 5, 1996Date of Patent: August 10, 1999Inventor: Linsey McLean
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Patent number: 5914135Abstract: Calcium carbonate liquid antacid compositions containing one or more pH adjusting agents to maintain the pH above 9.0, preferably above 9.5. The resultant antacid liquid possesses superior resistance to microbial attack and enhanced taste properties.Type: GrantFiled: April 16, 1997Date of Patent: June 22, 1999Assignee: McNeil-PPC, Inc.Inventors: John J. Dubek, Gerard P. McNally, Bruce P. Smith
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Patent number: 5882689Abstract: This invention provides a method for controlling soilborne fungal disease in cultivated field plants such as a peanut crop. Field crop soil is treated with a free-flowing granular fungicide composition which can be applied by aerial means with minimal settling on plant foliage. The granular fungicide composition comprises ammonium bicarbonate and a solid surfactant ingredient, and is effective against soilborne fungi such as a Sclerotinia, Rhizoctonia, Pythium, Fusarium, Phytophthora or Verticillium species.Type: GrantFiled: December 23, 1997Date of Patent: March 16, 1999Assignee: Church & Dwight Co., Inc.Inventors: M. Steven Lajoie, Carl E. Henry
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Patent number: 5879708Abstract: The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula ##STR1## wherein R.sup.1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R.sup.2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl, R.sup.3 and R.sup.5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R.sup.4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt stabilizing agent, is physically stable. Magnesium and calcium basic inorganic salt stabilizing agents are particularly useful.Type: GrantFiled: February 27, 1997Date of Patent: March 9, 1999Assignee: Takeda Chemical Industries, Ltd.Inventors: Tadashi Makino, Tetsuro Tabata, Shin-Ichiro Hirai
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Patent number: 5874065Abstract: The invention describes an oral anti-acid paste comprising anti-acid compound in a slow releasing carrier medium which disperses the anti-acid, and releases the anti-acid from the paste upon contact with the aqueous media such as saliva. The paste can be used by placement in the mouth for slow release of the anti-acid into the saliva thereby contacting the mucosa of the esophagus to inhibit irritation to the mucosa due to excess acid.Type: GrantFiled: June 26, 1997Date of Patent: February 23, 1999Inventor: Alan A. Pardini
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Patent number: 5858413Abstract: A pharmaceutical, oral composition of a liquid to semisolid consistency is disclosed, wherein the composition, substantially free of preservatives, contains at least one antacid active substance as well as more than 45% by weight, a sugar and/or sugar alcohol, relative to the ready-to-use composition, and up to 40% by weight, a pharmaceutically harmless solvent, relative to the ready-to-use composition.Type: GrantFiled: July 23, 1996Date of Patent: January 12, 1999Assignee: Rhone-Poulenc Rorer GmbHInventors: Winfred Jettka, Jorg-Christian Hager, Manfred Durr
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Patent number: 5830508Abstract: A calcium-based ophthalmic composition for treating dry eye is disclosed. The composition includes a hydrophobic carrier such as petrolatum and a calcium salt. The composition can further include a polyol such as glycerol, and an agent such as anhydrous lanolin, to enhance the interface between the carrier, and the calcium salt and polyol. Also disclosed is a method for treating dry eye comprising the step of administering the composition according to the present invention by placing the composition on the lateral portion of the lower eyelid margin. This method allows the composition to gradually disperse onto the cornea and conjunctiva.Type: GrantFiled: January 21, 1997Date of Patent: November 3, 1998Assignee: Deo CorporationInventor: Donald L. MacKeen
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Patent number: 5814319Abstract: An anti-viral, anti-bacterial, and anti-cancer agent comprising as the effective component, an alkali extraction of Aspalathus linearis which is preferably obtained after extraction by hot water. The agent serves to treat and prevent bacterial infections; to treat and prevent cancer; and to treat or prevent viral infection, for example, infection caused by retroviruses, such as human T-cell leukemia and the AIDS virus. The agent has no side effects.Type: GrantFiled: March 22, 1996Date of Patent: September 29, 1998Assignee: Mitsui Norin Co., Ltd.Inventor: Masatoshi Nakano
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Patent number: 5807580Abstract: A pharmaceutical composition for oral administration comprising a film coated tablet exhibiting enhanced disintegration characteristics, said film coating comprising a hydrophilic film forming polymer such as hydroxypropyl methylcellulose and an alkaline agent wherein the alkaline agent reduces the disintegration time of the film coating by increasing the rate of removal of the film coating polymers.Type: GrantFiled: October 30, 1996Date of Patent: September 15, 1998Assignee: McNeil-PPC, Inc.Inventor: Joseph R. Luber
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Patent number: 5776505Abstract: The invention relates to the combined use of ketoprofen and specific inorganic basic substances with an improved quality of action.Type: GrantFiled: August 30, 1996Date of Patent: July 7, 1998Assignee: Bayer AktiengesellschaftInventors: Joachim Maasz, Ingrid Hurner, Peter Kurka, Ralph Lange
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Patent number: 5776503Abstract: The present invention provides a dialysis solution that contains amino acids for treating and/or preventing malnutrition in a peritoneal dialysis patient. The amino acid composition is optimized to minimize metabolic acidosis while normalizing amino acid plasma profiles.Type: GrantFiled: July 24, 1997Date of Patent: July 7, 1998Assignee: Baxter International Inc.Inventors: Leo Martis, Michael R. Jones
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Patent number: 5759586Abstract: There is disclosed a pharmaceutical or dietetic composition, comprisingsodium, potassium, magnesium and calcium ions, wherein at least sodium and potassium are present as carbonates and/or bicarbonates, andenzyme activators,the mass ratio of K:Ca:Na:Mg being 0.1-100:0.05-80:0.03-50:1, the composition containing at least 40 mmol of alkaline or alkalizing ions and the composition, dissolved in water, having a pH of .gtoreq.7.5.Type: GrantFiled: October 2, 1996Date of Patent: June 2, 1998Inventors: Norbert Fuchs, Norbert Zelch, Peter Koessler, Rupert Loidl
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Patent number: 5760094Abstract: Hydrolyzed gelatin has been found to provide an improvement in taste and mouthfeel when incorporated in small amounts into chewable tablets containing ingredients requiring taste masking. Medicinals and nutritional supplements may now be prepared as chewables for those who find tablets difficult to swallow, for example children and older adults, or for those who prefer the convenience. There is a particularly large improvement in the taste and mouthfeel of chewables incorporating magaldrate and/or calcium carbonate.Type: GrantFiled: May 6, 1997Date of Patent: June 2, 1998Assignee: Bayer CorporationInventors: Thomas A. Alexander, Lawrence J. Daher, Gerald Gold, Clarence L. Hancock, Donald L. Peterson
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Patent number: 5716649Abstract: A batch process for increasing the calcium content of a water solution comprises the placement of a tin catalyst, a glass fibrous material, and water into a sealed tank and the application of heat to the tank for predetermined time intervals at progressively decreasing temperatures. The resulting solution is then extracted from the tank, wherein the solution has between 200 ppm and 500 ppm concentration of calcium.Type: GrantFiled: March 20, 1997Date of Patent: February 10, 1998Inventor: Wal Hee Nam
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Patent number: 5716648Abstract: Compositions for use in the regulation of subnormal pH values in intestinal tract and for treatment of bowel diseases. The compositions comprise a coating and a substantially insoluble alkaline material confined within said coating, the composition being adapted so as to ensure the availability of an amount of said pH regulating alkaline material in the lumen of the gastrointestinal tract exhibiting subnormal pH values. E.g. In the proximal small intestine, the mid small intestine, the distal small intestine, the caecum, the ascending colon, the transverse colon, the descending colon, the sigmoid colon and/or the rectum. The compositions may also comprise a medicament for treatment of bowel disease, e.g. 5-aminosalicylic acid for the treatment of Crohn's disease and colitis ulcerosa. The administration may be oral composition or enemas or suppositories.Type: GrantFiled: December 21, 1995Date of Patent: February 10, 1998Assignee: Farmaceutisk Laboratorium Ferring A/SInventors: S.o slashed.ren Halskov, Svenn Kluver Jepsen
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Patent number: 5698230Abstract: The present invention provides a dialysis solution that contains amino acids for treating and/or preventing malnutrition in a peritoneal dialysis patient. The amino acid composition is optimized to minimize metabolic acidosis while normalizing amino acid plasma profiles.Type: GrantFiled: March 24, 1997Date of Patent: December 16, 1997Assignee: Baxter International Inc.Inventors: Leo Martis, Michael R. Jones
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Patent number: 5693344Abstract: A hazard-free method for controlling insects using a non-toxic composition. The invention includes a process for making the composition in the form of a fragrance and crystalline particles which puncture directly through the exoskeleton of an insect. In operation, the particles work themselves between the insect's protective body plates and then puncture the exoskeleton permitting entry of the fragrance into the body of the insect. Once inside, the particles absorb up to four times their weight of the vital body fluids of the insect and the fragrance has a neural effect on the insect.Type: GrantFiled: November 9, 1995Date of Patent: December 2, 1997Assignee: Ecosmart, Inc.Inventors: Arthur Michael Knight, Steven M. Bessette
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Patent number: 5670176Abstract: The present invention provides a dialysis solution that contains amino acids for treating and/or preventing malnutrition in a peritoneal dialysis patient. The amino acid composition is optimized to minimize metabolic acidosis while normalizing amino acid plasma profiles.Type: GrantFiled: April 4, 1995Date of Patent: September 23, 1997Assignee: Baxter International Inc.Inventors: Leo Martis, Michael R. Jones
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Patent number: 5665782Abstract: Hydrolyzed gelatin has been found to provide an improvement in taste and mouthfeel when incorporated in small amounts into chewable tablets containing ingredients requiring taste masking. Medicinals and nutritional supplements may now be prepared as chewables for those who find tablets difficult to swallow, for example children and older adults, or for those who prefer the convenience. There is a particularly large improvement in the taste and mouthfeel of chewables incorporating magaldrate and/or calcium carbonate.Type: GrantFiled: May 4, 1995Date of Patent: September 9, 1997Assignee: Miles Inc.Inventors: Thomas A. Alexander, Lawrence J. Daher, Gerald Gold, Clarence L. Hancock, Donald L. Peterson
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Patent number: 5661137Abstract: Antiacid pharmaceutical compositions in the form of suspensions containing sucralphate gel as an active ingredient combined with suitable excipients and/or diluents.Type: GrantFiled: January 29, 1996Date of Patent: August 26, 1997Assignee: Laboratorio Italiano Biochimico Farmaceutico Lisapharma S.p.A.Inventor: Giorgio Zagnoli
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Patent number: 5656652Abstract: Compositions for oral administration for the treatment of gastric disorders comprising histamine H.sub.2 -receptor antagonist, and antacid, optimally buffered to promote local absorption of the H.sub.2 -receptor antagonist, wherein the quantity of H.sub.2 -receptor antagonist per unit dosage form is less than 25 mg.Type: GrantFiled: June 15, 1994Date of Patent: August 12, 1997Assignee: SmithKline Beecham plcInventor: Adrian Francis Davis
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Patent number: 5651997Abstract: An antacid composition comprises, as antacid ingredients, a hydrotalcite and dihydroxyaluminium aminoacetate in such a ratio that the former/the latter equals 30/70 to 90/10 (by weight). The composition may further comprises a readily acting or rapid effecting antacid ingredient such as a magnesium hydroxide in an amount of 10 to 50% by weight. The antacid composition is improved in antacid properties and rapid effecting properties, and is useful as a pharmaceutical composition comprising the antacid composition, a carrier, an additive, an additional pharmaceutically active ingredient and so on. The total amount of the antacid ingredients in the pharmaceutical composition may be 10% by weight or more. The pharmaceutical composition may be formed into a fine granule or a granule with utilizing granulation, or into a tablet by compression-molding.Type: GrantFiled: September 12, 1996Date of Patent: July 29, 1997Assignee: Takeda Chemical Industries, Ltd.Inventors: Tadashi Makino, Shigeyuki Marunaka, Soichiro Imoto
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Patent number: 5641511Abstract: A novel granular drug delivery system having a gel-forming dietary fiber that can be made into a an orally-ingestible dispersion by admixture with a liquid that can deliver an effective dose of a pharmaceutically-active compound. The granular drug delivery system comprises granules consisting essentially of a pharmaceutically active compound, and a gel-forming dietary fiber, the granules being coated with at least one of the following: a gel-forming dietary fiber, a starch or a protein. The composition may further include a mineral salt that releases a physiologically-acceptable gas upon ingestion. The composition of the granular drug delivery system will deliver microgram quantities of a pharmaceutically-active compound in an orally-ingestible dispersion without forming a thick gel and without forming "hot" and "cold" spots of the pharmaceutically-active compound.Type: GrantFiled: September 13, 1995Date of Patent: June 24, 1997Assignee: Cibus PharmaceuticalInventor: Eric H. Kuhrts
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Patent number: 5639478Abstract: The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula ##STR1## wherein R.sup.1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R.sup.2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl, R.sup.3 and R.sup.5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R.sup.4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt stabilizing agent, is physically stable. Magnesium and calcium basic inorganic salt stabilizing agents are particularly useful.Type: GrantFiled: June 7, 1995Date of Patent: June 17, 1997Assignee: Takeda Chemical Industries, Ltd.Inventors: Tadashi Makino, Tetsuro Tabata, Shin-Ichiro Hirai
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Patent number: 5631025Abstract: An improved peritoneal dialysis solution and methods of administering same to a patient are provided. Pursuant to the present invention, the sodium concentration in the solution is decreased thus causing sodium to be transported from the circulation to the peritoneal cavity. This provides for an improved ultrafiltration profile for the same initial osmolality when compared to standard solutions. Also, the same ultrafiltration profile as standard solutions can be achieved with lower initial osmolalities.Type: GrantFiled: April 18, 1995Date of Patent: May 20, 1997Assignee: Baxter International Inc.Inventors: Ty R. Shockley, Leo Martis, Lee W. Henderson, John Moran, Masaaki Nakayama
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Patent number: 5629026Abstract: Compositions for oral administration for the treatment of gastric disorders comprising histamine H.sub.2 -receptor antagonist and antacid, optionally buffered to promote local absorption of the H.sub.2 -receptor antagonist, wherein the quantity of H.sub.2 -receptor antagonist per unit dosage form is less than 25 mg.Type: GrantFiled: May 17, 1995Date of Patent: May 13, 1997Assignee: SmithKline Beecham plcInventor: Adrian F. Davis
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Patent number: 5629025Abstract: An improved peritoneal dialysis solution comprising an osmotic agent having at least one amino acid, and a method of administering same to a patient are provided. Pursuant to the present invention, the sodium concentration in the solution is decreased thus causing sodium to be transported from the circulation to the peritoneal cavity. This provides for an improved ultrafiltration profile that is, more volume over a longer period of time, for the same initial osmolality when compared to standard solutions. Also, the same ultrafiltration profile as standard solutions can be achieved with lower initial osmolalities.Type: GrantFiled: April 18, 1995Date of Patent: May 13, 1997Assignee: Baxter International Inc.Inventors: Ty R. Shockley, Leo Martis, Lee W. Henderson, John Moran, Masaaki Nakayama
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Patent number: 5612061Abstract: A composition for the treatment of premenstrual syndrome comprising an effective amount of calcium, magnesium, an analgesic and a diuretic sufficient to reduce the symptoms of premenstrual syndrome.Type: GrantFiled: October 14, 1994Date of Patent: March 18, 1997Inventor: Simon W. Rabkin
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Patent number: 5605934Abstract: The present invention provides improved methods for manufacturing solutions including medical solutions. To this end, in an embodiment, a method for preparing a medical solution is provided comprising the steps of: placing a solution in a gas permeable container; and allowing carbon dioxide to permeate through the container until a desired pH is achieved.Type: GrantFiled: March 23, 1995Date of Patent: February 25, 1997Assignee: Baxter International Inc.Inventor: Joseph A. Giertych
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Patent number: 5589197Abstract: A peritoneal dialysis solution and method of administering same to a patient are provided wherein the sodium concentration in the solution is decreased thus causing sodium to be transported from the circulation to the peritoneal cavity. This provides for an improved ultrafiltration profile (more volume over a longer period of time) for the same initial osmolality when compared to standard solutions. Also, the same ultrafiltration profile as standard solutions can be achieved with lower initial osmolalities. A reduced amount of osmotic agent can be used to achieve equivalent ultrafiltration.Type: GrantFiled: March 3, 1994Date of Patent: December 31, 1996Assignee: Baxter International, Inc.Inventors: Ty R. Shockley, Leo Martis, Lee W. Henderson, John Moran, Masaaki Nakayama
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Patent number: 5545670Abstract: This invention relates to a composition and method for the treatment of myalgic encephalomyelitis known as chronic fatigue syndrome. The composition consists essentially of specific amounts of L-methionine, magnesium salts, folic acid, vitamin B.sub.6, and vitamin B.sub.12.Type: GrantFiled: June 8, 1994Date of Patent: August 13, 1996Inventors: Siegbert H. Bissbort, Henry J. Davis
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Patent number: 5496566Abstract: A method of installing in a building a suspension containing paramagnetic susceptible elements consisting essentially of:(A) providing in a non-metallic container 5-12 pounds of a composition consisting essentially of (i) 30-99 wt % of a carbonate or a mixture of two or more carbonates selected from the group consisting of magnesium carbonate, calcium carbonate, strontium carbonate, barium carbonate and mixtures thereof, wherein the carbonate or mixture of carbonates are in powder form, (ii) 1-70 wt % of activated carbon in powder form, (iii) 0.Type: GrantFiled: July 19, 1994Date of Patent: March 5, 1996Inventors: Raymond C. Crippen, Carleton T. Miller
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Patent number: 5490985Abstract: An antacid product having extended duration of residence in the gastric and upper intestinal systems has been developed. This antacid product includes a blend of 10-70% by volume nonphospholipid lipid vesicles, with a particulate base. An antiflatulence agent may also be included. A method of providing extended duration amelioration of acid build up in the gastric and upper intestinal tract using this product is also disclosed.Type: GrantFiled: March 18, 1994Date of Patent: February 13, 1996Assignee: Micro-Pak, Inc.Inventors: Donald F. H. Wallach, Rajiv Mathur, Jean Philippot, Surendra Kumar
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Patent number: 5468716Abstract: The present invention provides a fungicide composition which contains ingredients which are biocompatible for purposes of agricultural applications, and which are harmless to animals and humans. An invention fungicide composition in the form of a dry blend formulation remains non-caking and free-flowing under storage conditions. Illustrative of an invention fungicide composition is a formulation which has a content of sodium bicarbonate, potassium bicarbonate, xanthan gum, dialkylsulfosuccinate salt and alkyl sulfate salt surfactants, and magnesium silicate anti-caking ingredient. The xanthan gum and surfactants function as an effective spreader-sticker and film-forming medium when the composition is diluted with water for agricultural applications.Type: GrantFiled: October 3, 1994Date of Patent: November 21, 1995Assignee: Church & Dwight Co., Inc.Inventor: Anthony E. Winston
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Patent number: 5466469Abstract: A novel granular drug delivery system having a gel-forming dietary fiber that can be made into a an orally-ingestible dispersion by admixture with a liquid that can deliver an effective dose of a pharmaceutically-active compound. The granular drug delivery system comprises granules consisting essentially of a pharmaceutically active compound, and a gel-forming dietary fiber, the granules being coated with at least one of the following: a gel-forming dietary fiber, a starch or a protein. The composition may further include a mineral salt that releases a physiologically-acceptable gas upon ingestion. The composition of the granular drug delivery system will deliver microgram quantities of a pharmaceutically-active compound in an orally-ingestible dispersion without forming a thick gel and without forming "hot" and "cold" spots of the pharmaceutically-active compound.Type: GrantFiled: March 28, 1994Date of Patent: November 14, 1995Assignee: Cibus Pharmaceutical, Inc.Inventor: Eric H. Kuhrts
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Patent number: 5461082Abstract: The object of the present invention is to prepare a dried aluminum hydroxide gel featuring excellent acid neutrizing capacity, but which is also stable.A dried aluminum hydroxide gel with a chemical composition represented by the following general formulas:(M.sub.2 O).sub.x Al.sub.2 O.sub.3 (CO.sub.2).sub.y R.sub.z.mH.sub.2 O or[(M.sub.2 O).sub.x1 (CaO).sub.x2 (MgO).sub.x3 ]Al.sub.2 O.sub.3 (CO.sub.2).sub.y R.sub.z.mH.sub.2 O(wherein M is a monovalent alkali metal and R is an organic acid with a valence of two or more. As a result of its organic acid content, the gel is stable and can have a grater aluminum content, thus improving the acid neutrizing capacity of the gel.Type: GrantFiled: July 8, 1994Date of Patent: October 24, 1995Assignee: Fuji Chemical Industry Co., Ltd.Inventors: Hitoshi Machimura, Hiroshi Kawaguchi, Akira Ohtsuga
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Patent number: 5455050Abstract: The present invention relates to an aqueous pharmaceutical suspension for oral use, and a method of preparation, having antacid and antiulcer properties which contains a therapeutically effective amount of calcium carbonate in combination with magnesium carbonate and/or magnesium trisilicate and a carboxylic acid pH adjusting agent.Type: GrantFiled: November 12, 1993Date of Patent: October 3, 1995Assignee: McNeil-PPC, Inc.Inventors: Douglas S. Beyerle, Gerard P. McNally
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Patent number: 5447918Abstract: A composition comprising sucralfate and one or more anti-acid epigastralgic relieving agents in a weight ratio of between 0.5:1.0 to 1.3 sucralfate to anti-acid epigastralgic relieving agent and a method of using the composition for relieving symptoms of gastrointestinal mucosal irritation in mammals. The composition may be either in liquid or solid dose form having a combined composition weight percentage of 10-30% per 5 milliliter volume of liquid or 40-85% per solid unit dose form.Type: GrantFiled: March 4, 1994Date of Patent: September 5, 1995Inventor: Ricky W. McCullough
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Patent number: 5441748Abstract: An aqueous agent for disintegrating gallstones containing an alkali metal carbonate such as sodium or potassium hydrogen carbonate and optionally N-acetylcysteine.Type: GrantFiled: November 10, 1993Date of Patent: August 15, 1995Assignee: Senju Pharmaceutical Co., Ltd.Inventor: Akihito Moyiyasu
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Patent number: 5439690Abstract: A hazard-free method for controlling insects using a non-toxic composition that kills by dehydration. The invention includes a process for making the composition in the form of crystalline particles which penetrate directly through the exoskeleton of an insect. In operation, the particles work themselves between the insect's protective body plates and then pierce the exoskeleton. Once inside, the particles absorb up to four times their weight of the vital body fluids of the insect. The penetration of the body plates and exoskeleton and/or dehydration ultimately results in death of the insect.Type: GrantFiled: May 21, 1993Date of Patent: August 8, 1995Assignee: Ecosmart, Inc.Inventor: Arthur M. Knight
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Patent number: 5433959Abstract: The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula ##STR1## wherein R.sup.1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R.sup.2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl, R.sup.3 and R.sup.5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R.sup.4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt stabilizing agent, is physically stable. Magnesium and calcium basic inorganic salt stabilizing agents are particularly useful.Type: GrantFiled: September 10, 1993Date of Patent: July 18, 1995Assignee: Takeda Chemical Industries, Ltd.Inventors: Tadashi Makino, Tetsuro Tabata, Shin-ichiro Hirai
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Patent number: 5415877Abstract: The present invention provides a fungicide composition which contains ingredients which are biocompatible for purposes of agricultural applications, and which are harmless to animals and humans. An invention fungicide composition in the form of a dry blend formulation remains non-caking and free-flowing under storage conditions. Illustrative of an invention fungicide composition is a formulation which has a content of sodium bicarbonate, potassium bicarbonate, xanthan gum, dialkylsulfosuccinate salt and alkyl sulfate salt surfactants, and magnesium silicate anti-caking ingredient. The xanthan gum and surfactants function as an effective spreader-sticker and film-forming medium when the composition is diluted with water for agricultural applications.Type: GrantFiled: December 22, 1993Date of Patent: May 16, 1995Assignee: Church & Dwight Co., Inc.Inventor: Anthony E. Winston
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Patent number: 5393535Abstract: A calcium ion containing composition comprising a water in oil emulsion having a dispersed aqueous phase and a continuous oil phase, which composition is orally administerable and palatable to cows without causing lesions of the stomach and which composition is effective in preventing milk fever, said composition further comprising a calcium salt which is dissolved in the aqueous phase to form a calcium ion containing aqueous phase solution, the calcium in the composition, calculated as free calcium ion, comprising 10 to 20 percent by weight of the composition, said composition further including from 0.5 to 10 percent oil soluble non-ionic emulsifier. The invention also includes the method of orally administering the composition to cows to treat milk fever.Type: GrantFiled: October 25, 1991Date of Patent: February 28, 1995Inventor: Gunnar Kjems
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Patent number: 5366739Abstract: A method for prolonged delivery of a therapeutic agent to the eye is disclosed. The method provides for the addition of a desired drug to a suitable, preferably non-aqueous, vehicle. An amount of the vehicle containing a therapeutic dose of the drug is placed on the extraocular skin adjacent to the lateral canthus of the eye. Movements of the orbicularis oculi associated with the scissor-like closing of the lids of the eye continuously transport small portions of the drug containing vehicle into the interpalpebral space where the drug is released to the cornea for intraocular penetration and treatment effected. The method of the invention is particularly effective in delivering insoluble calcium salts for the treatment of dry eye.Type: GrantFiled: December 19, 1992Date of Patent: November 22, 1994Assignee: DEO CorporationInventor: Donald L. MacKeen
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Patent number: 5358722Abstract: Ferritin analogs comprising an apoferritin protein shell and a core substantially devoid of ferrihydrite, e.g. of inorganic composition such as aluminum hydroxide or organic composition such as acetaminophen. The protein shell can be removed from ferritin analog to produce spherules having a substantially monomodal nominal diameter between about 45 and 90 Angstroms.Type: GrantFiled: January 25, 1993Date of Patent: October 25, 1994Assignee: Monsanto CompanyInventor: Bruce F. Monzyk