Abstract: This invention is directed to a transdermal delivery patch comprising local anesthetic agent and optionally a permeation enhancement agent for reducing neuropathic pain.

Abstract: The invention provides a method for validating the functioning of an apparatus with a static mixing device for mixing two liquid streams for producing nanoparticles. The static mixing device may be a jet impingement reactor. The method is based on the use of PLA, PLG or PLGA for producing polymeric nanoparticles with highly reproducible particle sizes. The invention further provides kits and liquid compositions for carrying out the method.

Abstract: The present invention relates to compositions comprising a silicate and methods of use thereof. In particular, the compositions of the present invention are suitable for treating inflammatory conditions, cancer, bacterial and viral infections, and infected and uninfected wounds. The compositions of the present invention can also be useful in treating spinal cord injury, tissue remodeling, and promoting bone growth and repair.

Abstract: An amorphous precipitated silica with controlled abrasivity and effective cleaning properties for use in an oral composition produced through comminution and classification of the silica to form particles with an oil absorption value of 150 cm3/100 g or less, a weight median particle diameter dso of less than 3 ?m and a dgo value, wherein 90% by weight of the particles have a diameter less than the dgo value, of 6 ?m or less.

Abstract: This invention relates, e.g., to a composition comprising two or more of: (a) N-acetylcysteine and/or (b) simethicone and/or (c) a docusate salt. In one embodiment of the invention, the amounts of (a) and/or (b) and/or (c) are effective, when the composition is administered into a colon of a subject undergoing colonoscopy, to cleanse a region of the colon in the visual field of the colonoscope so that the region contains no adherent stool or intestinal secretions obscuring the visual field. Methods for using this or other compositions of the invention, e.g. to cleanse the colon of a subject in order to enhance visualization of the colon during a colonoscopy, are also described, as are kits for carrying out methods of the invention.

Abstract: The invention provide a silica nanoparticle comprising a non-porous matrix of silicon-oxygen bonds, wherein the matrix comprises organic agents conjugated to silicon or oxygen atoms in the matrix, the organic agents are conjugated to the matrix through linker L groups, wherein the linker L comprises, for example, an ester, urea, thiourea, or thio ether group, and wherein the diameter of the nanoparticle is about 15 nm to about 200 nm. The invention also provides novel methods of making and using the silica nanoparticles described herein.

Abstract: Formulations containing reactive oxygen species (ROS), processes for making these formulations, and methods of using these formulations are described. The formulations can include gels or hydrogels that contain at least one reactive oxygen species (ROS). The formulations can include a composition containing a reduced species (RS) and a reactive oxygen species (ROS). The formulations can also contain a rheology modifier and can include gels or hydrogels. Methods of preparing the formulations can include preparing a composition. Compositions can be prepared by providing water, purifying the water to produce ultra-pure water, combining sodium chloride to the ultra-pure water to create salinated water, and electrolyzing the salinated water at a temperature between about 4.5 to about 5.8° C.

Abstract: The natural insect repellent BBX2 is a composition of refined oils such as Citronella, Cedar, Mineral, Castor, and Oleic Acid with Diatomaceous Earth to repel insects from landing on and remaining on human skin. It can be made in many different forms such as liquid, lotion, spray, paste, cream and can be a part of articles such as animal collars, garbage bags, planting material, and of course fabrics for clothing, tents, and anything that a person would use or wear.

Abstract: A sunscreen composition for application for plants comprises Titanium Dioxide (TiO2), Zinc Oxide (ZnO), Silicon Dioxide (SiO2), a surfactant, wetting agent, dispersant (SWD) and water. The composition forms a suspension concentrate when combined that when diluted in water provides a solution that provides uniform coverage using convention spraying equipment. A method of protecting plants including turfgrass from ultraviolet radiation, heat stress and/or sunburn comprises combining TiO2, ZnO, SiO2, SWD and water to form a suspension concentrate. The suspension concentrate is then diluted in water and applied to an area in which sun protection is desired.

Abstract: The invention encompasses compositions and methods for treating and modifying surfaces of teeth, which compositions include calcium and magnesium containing silicates or silica, cationic polymer modified silica or combinations thereof. The composition when applied to the teeth or a tooth surface deposit on such surfaces to repair acid damaged enamel and prevent further erosion of a tooth surface.

Abstract: A nutritional product composition for increasing human growth hormone and nitric oxide production, to increase lean muscle mass, decrease body fat, and improve cardiovascular function and immune function. The nutritional product composition includes a synergistic blend of nutrients and a silica gel that increases the rate of metabolism of cells to increase the rate of absorption of the nutrients and elevate the production of the human growth hormone and elevate nitric oxide production. The synergistic blend of nutrients includes colostrum, L-arginine, potassium citrate and goji berry extract. The silica gel increases an absorption rate of the synergistic blend.

Abstract: The invention is a shaving formulation comprising 0.3 to 5% by weight of noncrystalline amorphous silicon dioxide SiO2 which has not been produced pyrogenically, having a particle size of 2 to 30 ?m.

Abstract: Disclosed herein is a continuous process for preparing a silica product, comprising: (a) continuously feeding an acidulating agent and an alkali metal silicate into a loop reaction zone comprising a stream of liquid medium; wherein at least a portion of the acidulating agent and the alkali metal silicate react to form a silica product in the liquid medium of the loop reaction zone; (b) continuously recirculating the liquid medium through the loop reaction zone; and (c) continuously discharging from the loop reaction zone a portion of the liquid medium comprising the silica product. Silica products and dentifrice compositions comprising the silica products are also disclosed. A continuous loop reactor is also disclosed.

Abstract: The present invention relates to a composition for oral use in the treatment of gastrointestinal pathologies comprising silicone antifoaming agents in an oily solvent medium, wherein the concentration of said silicone antifoaming agents is between 0.1% and 80% by weight.

Abstract: A herbomineral composition for the treatment of sickle cell disease is described in the present invention. The herbo mineral composition include some herbal ingredients such as Jaiphal, Sunthi, Jivanti, Haritaki, Guduchi, Shatavari, Dadima, Pippali, along with the therapeutic minerals such as Abrakha Bhasma and Loha Bhasma at suitable concentrations to obtain synergistic anti sickling activity. The composition exhibited up to 60-87% antisickling activity on RBCs in ‘vitro’ at various concentrations. Patients treated with this composition found relief from most of the severe symptoms of sickle cell disease and sickle cell anemia, and had excellent improvement in quality of life.

Abstract: Layered phyllosilicates are useful for adsorbing and/or binding to cholesterol and, thereby, reducing blood cholesterol in a patient. Accordingly, provided herein is a method of reducing hypercholesteremia in a mammal comprising administering to the mammal a protonated and at least partially exfoliated layered phyllosilicate material alone and in combination with other cholesterol-reducing agents in an amount effective to reduce hypercholesteremia in the mammal. Also provided are methods of treating a cardiovascular disorder associated with atherosclerosis in a mammalian subject comprising administering to the subject a layered phyllosilicate material in an amount effective to reduce atherosclerotic lesion formation in the subject.

Abstract: Water-soluble, solid, film-shaped preparations comprising at least one film-forming polymer selected from the group consisting of the fully and partially hydrolyzed polyvinyl alcohols, and at least one water-insoluble, oily liquid which is incorporated into the film-forming polymer and amounts to at least 30 percent by weight, relative to the dry portion of the preparation. Methods for producing the preparations and the use thereof are also provided.

Abstract: The present invention provides novel compositions comprising a nutritional supplement containing vitamin D-3 (cholecalciferol) and other supporting nutrients (i.e., fat-soluble vitamins A and E) to be administered orally via capsules to human subjects for the prophylaxis and mitigation of hair thinning and hair loss in both men and women. Colloidal silicon dioxide functions to form a nanoparticulate suspension and acts as a viscosifier to thicken the oil(s) used in the capsule filling operation. The colloidal silica contains silicon which acts as a nutrient to help strengthen existing hair, and also functions as a microencapsulation agent, which can incorporate vitamins A and E into its porous structure by sonication.

Abstract: An oral care composition comprising a fused silica abrasive, wherein the composition has a stable viscosity.

Abstract: The present invention utilizes a nano-coating of an oxide such as silica, a silicate or another effective oxide on a surface to accelerate blood clotting in mammalian animals. The hemostatic layer has a thickness that is effective for the hemostasis, yet can be made thin enough to result in a resorbable film which can either be applied to a biocompatible or resorbable device that can be used in surgical applications as well as in topical applications such as trauma.

Abstract: The invention relates to a method for the preparation of a silicic acid comprising extrudate, comprising the steps of: i) forming of stabilized silicic acid, by hydrolysing a silicon compound into orthosilicic acid and/or oligomers thereof in the presence of a stabilizing agent, which is a quaternary ammonium compound, or an amino-acid, or an amino acid source or combinations thereof; ii) mixing of the stabilized silicic acid with a carrier in an amount upto the loading capacity of the carrier for silicic acid; and iii) extruding the resulting mixture thereby forming the extrudate, to extrudates obtainable with the method, to an extrudate for use in the production of animal feed, feed supplement, human food and/or food supplement and of a pharmaceutical or cosmetic preparation, and for the treatment of infections, nails, hair, skin, teeth, collagen, connective tissue, bones, osteopenia, cell generation and degenerative (ageing) processes, and to a pharmaceutical composition comprising an extrudate.

Abstract: Methods are provided for producing compositions, e.g. pastes or clays, which rapidly set into high-strength calcium phosphate products. In the subject methods, dry reactants that include calcium and phosphate sources, as well as a monovalent cation dihydrogen phosphate salt, are combined with a setting fluid and the combined reactants are mixed to produce the settable composition. A feature of the invention is that cements rapidly set into high strength product compositions. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including hard tissue repair applications.

Abstract: A method for prevention and/or treatment of steatorrhea in a subject, is disclosed.

Abstract: A method for manufacturing a porous ceramic scaffold having an organic/inorganic hybrid coating layer containing a bioactive factor includes (a) forming a porous ceramic scaffold; (b) mixing a silica xerogel and a physiologically active organic substance in a volumetric ratio ranging from 30:70 to 90:10 and treating by a sol gel method to prepare an organic/inorganic hybrid composite solution; (c) adding a bioactive factor to the organic/inorganic hybrid composite solution and agitating until gelation occurs; and (d) coating the porous ceramic scaffold with the organic/inorganic composite containing the bioactive factor added thereto. In accordance with the method, the porous ceramic scaffold may be uniformly coated with the organic/inorganic hybrid composite while maintaining an open pore structure, and stably discharge the bioactive factor over a long period of time.

Abstract: Granules or pellets comprising polymeric materials such as polyaryletherketones and ceramic materials may be prepared and used to make a variety of different parts of components for use in medical applications, by melt-processing. The ceramic material may be a bioactive glass and/or a controlled-release glass, and may include less than 20 mole % sodium oxide and/or be water soluble.

Abstract: The present invention relates to methods and compositions for inhibiting, treating, and preventing dental diseases in human and non-human animals, particularly domesticated companion animals. More particularly, the present invention relates to the unexpected discovery that the combination of micron-sized particulate bioactive glass and a topical bisphosphonate yields a composition that is capable of treating and/or preventing dental problems such as periodontal disease, tooth decay and tooth resorption in animals, particularly small mammals such as cats.

Abstract: The disclosure is directed to glass compositions that incorporate copper into an otherwise homogeneous glass and to a method for making such glass. This incorporation of the copper into the glass composition imparts significant antimicrobial activity to the glass. A method of making a copper-containing glass article comprises: batching a glass batch comprising: 40-85 SiO2; 10-40 B2O3; 1-19 Al2O3; 0.1-20 CuO or a selected salt of Cu that is convertible into CuO during melting; 0-20 M2O, wherein M is Li, Na, K, or combinations thereof; 0-25 RO, wherein R is Ca, Sr, Mg, or combinations thereof; and 0-20 ZnO. melting the batch to form a melted glass; and forming the melted glass to form the copper-containing glass article having antimicrobial properties.

Abstract: The present invention relates to a new class of anitoxidant agent comprising a pharmaceutically acceptable silicate, resveratrol, grape seeds extract, green tea extract and tomato powder. In particular this composition comprises between 32 to 60 percent by weight of a pharmaceutically acceptable silicate, between 6 to 22 percent by weight of resveratrol, between 16 to 20 percent by weight of grape seeds extract, between 8 to 10 percent by weight of green tea extract, and between 10 to 16 percent by weight of tomato powder.

Abstract: Provided is a pharmaceutical composition containing inorganic nanoparticles selected from titanium oxide nanoparticles or silica nanoparticles as an active ingredient for preventing or treating angiogenesis-related diseases. The pharmaceutical composition for preventing or treating angiogenesis-related diseases according to the present invention may be used as a therapeutic agent for various diseases based on angiogenesis such as age-related macular degeneration, tumors, and diabetes-related complications.

Abstract: A powdery composition, comprising: a) core-shell particles having a shell of hydrophobic or hydrophobized particles; and b) a carrier powder comprising a carrier and at least one of an at least partially water soluble liquid and a water reactive substrate reversibly bound to the carrier by at least one of the capillary action, absorption and adsorption is provided. The core-shell particles have a core, comprising: water; and 0 to 10 wt. % of a total core weight of a dissolved or emulsified material. The carrier comprises at least one material selected from the group consisting of silica, a silica-metal mixed oxide, phyllosilicate, starch, hollow glass spheres, nylon, sugar, cyclodextrines and polysaccharides, and a weight ratio of the carrier powder to the core-shell particles is from 1/1 to 1/9.

Abstract: A skin care formulation includes a dispersion or emulsion including at least one particle-polymer hybrid and a cosmetically acceptable additive. The polymer-particle hybrid includes at least one particle grafted with at least one polymer. The skin care formulation provides improved water-resistance with limited impact on the sensory feel of the formulation (such as tackiness).

Abstract: Methods of preparing bioactive composites are described. Also described are methods of molding such composites. Shaped bodies comprising bioactive composites are further described.

Abstract: Provided is a technology that enables setting of a durable hairstyle and moreover, enables easy resetting of a hairstyle. A hairstyling agent composition having a hydrophobic silica and a dispersing liquid for dispersing the hydrophobic silica therein.

Abstract: The subject matter of the invention relates to the use of a composition comprising at least one oxide and/or hydroxide insoluble in an aqueous environment, preferably selected from silicon dioxide (SlO2), titanium dioxide (TlO2), aluminium oxide (AI2O3) and aluminium hydroxide (Al(OH)3), magnesium oxide (MgO), to reduce absorption of the ethanol ingested through the consumption of alcoholic beverages. The invention also comprises the use of food products comprising these mixtures for the aforesaid use.

Abstract: Provided are fibrous composites prepared by methods of the present invention, comprising oxides and biodegradable polymers, in which the fibers are made of aerogel-like oxide materials having nanometer-sized pores. The fibrous composition advantageously has, at least, the following characteristics: (i) a very high nanoporous surface area, which also permits nucleation of crystallites; (ii) mesoporous/macroporous interspacial networks between the fibers, providing high bioactivity and a high transport rate; (iii) macropores for natural bone-like tissue growth; (iv) good mechanical properties for handling and for implant support; and (v) biodegradability for implant dissolution and time-variable mechanical properties. Further provided are methods for using the bioactive biodegradable fibrous composites as osteogenic composite materials for tissue engineering, tissue re-growth, bone implants, and bone repair, and/or for the delivery of drugs or therapeutic compounds.

Abstract: A sunscreen composition for application for plants comprises Titanium Dioxide (TiO2), Zinc Oxide (ZnO), Silicon Dioxide (SiO2), a surfactant, wetting agent, dispersant (SWD) and water. The composition forms a suspension concentrate when combined that when diluted in water provides a solution that provides uniform coverage using convention spraying equipment. A method of protecting plants including turfgrass from ultraviolet radiation, heat stress and/or sunburn comprises combining TiO2, ZnO, SiO2, SWD and water to form a suspension concentrate. The suspension concentrate is then diluted in water and applied to an area in which sun protection is desired.

Abstract: Methods for forming surface roughened titanium dioxide coatings are disclosed. Sol-gel compositions may be prepared having colloidal metal oxide particles and/or colloidal silica particles, formed on a substrate, and subsequently the coated substrate may be heated at a temperature sufficient to form a surface roughened anatase titanium dioxide coating. Surface roughened titanium dioxide coatings having at least one of improved antimicrobial properties, self-cleaning properties, hydrophilicity, and/or activation time are also disclosed. Substrates comprising such coatings are also disclosed.

Abstract: A method for treating a wound, and a dressing for wound care management comprising a three-dimensional body of glass-based fibers comprising one or more glass-formers selected from the group consisting of P2O5, SiO2, and B2O3; at least about 25 wt % of the fibers have a diameter between about 200 nm and about 4000 nm, and a length:width aspect ratio of at least about 10. In another form, the glasses are in the form of particles in an ointment or cream applied to a wound. In yet other forms the glasses are employed as fibers formed into sutures for closing a wound, or as particles in a surgical glue for closing a wound.

Abstract: A phase change formulation includes a reversible phase change material and a thermal conductivity additive formulated for application to a user's epidermis.

Abstract: Dispersion containing, in addition to water, 0.5 to 20 wt. % of hydrophobic silica, 0.01 to 10 wt. % of a gelling or viscosity-increasing additive, 0.1 to 1 wt. % of a preservative and 0 to 1 wt. % of a surface-active substance. It is prepared by a procedure in which the individual components are dispersed successively or together into the water and in this procedure the individual components are deaerated before and/or during the addition or the dispersion is deaerated during the individual dispersing steps. The dispersion can be employed as an insecticide.

Abstract: In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) porogen particle that is also dispersed in the matrix. In further embodiments, the compositions of the present invention are also associated with one or more active agents. In various embodiments, the active agents are associated with the biodegradable polymer matrix, the biodegradable reinforcing particle, and/or the porogen particle. In various embodiments, the compositions of the present invention may be utilized as scaffolds, such as scaffolds for treating bone defects.

Abstract: The invention relates to a dental, particularly a remineralizing composition, effective for pain sensitive teeth, such as toothpaste, tooth powder, mouth wash, chewing gum, dental formulations or the like, comprising spherical dental particles having a particle size between 0.1 and 2 ?m made of silica gel in an one-part combination, comprising at least one combination agent selected from at least a phosphate, a oxide, a further oxygen-containing compound, a hydroxide, hydrogen carbonate or carbonate of the metals of groups II and III of the periodic system, as well as zinc or tin, wherein the dental particles are present in an amount such that the SiO2 amount resulting from the silica gel is less than 1 wt. %.

Abstract: Disclosed is a topical skin composition comprising an aqueous extract from a part of Nymphaea gigantea, wherein said part consists of the flower of Nymphaea gigantea, an aqueous extract from a part of Plumeria alba, wherein said part consists of the flower of Plumeria alba, and a dermatologically acceptable vehicle.

Abstract: The present invention relates to a dry composition for reconstitution in water comprising polyethylene glycol (PEG), optionally sodium sulphate, citric acid, sodium citrate, sodium chloride, potassium chloride, simethicone, effective for bowel cleansing, in particular of colon, prior to diagnostic, surgical or therapeutical procedures, in particular colonoscopy.

Abstract: The present invention is related to a formulation based on micronized natural calcite mineral consisting of: A. mineral part which is characterized: (i) by the particle size with diameter smaller than 5 ?m, where the distribution of particle size is such that minimum of 10% of particles are with diameter under 900 nm, with total surface of particles greater than 3.2 m2/g, and with total porous volume greater than 0.012 cm3/g, and by composition: (ii) CaCO3, MgCO3, FeCO3, MnCO3, ZnCO3 and SiO2 in mixtures where CaCO3 is presented in amount from 10% to 99% of mineral part; and B. adjuvant selected from the group consisting of: wetting agent, drift-control agent at application by spraying, humic acid salt, amino-acids salts, complex of plant micro-nutrients, vitamin, plant hormone, nitrogen fertilizer, potassium salt, borate salt, molybdate salt, plant extract, chlorophyll, yeast extract, or mixture of these substances; where A. and B. form an aqueous suspension wherein percentage of A. and B.

Abstract: The invention provides materials, compositions, methods, and kits for deterring or repelling animals from eating plant materials. The invention relates to the use of particulate matter to deter animals from eating plant materials that are susceptible to grazing by animals. In exemplary embodiments, an adhesive is applied to target plant material and the particulate matter is then applied prior to curing or drying of the adhesive.

Abstract: A mechanical insecticide is made by mixing water with at least one type of silane to make a silane solution which is then mixed with diatomaceous earth until there is substantial deposition of the silane material on the diatomaceous earth material, to make a silanized diatomaceous earth. The silanized diatomaceous earth can be diluted with water and applied to vertical and overhead surfaces using a sprayer, for the control of insects. The silanized diatomaceous earth can also be dried into a powder for broadcast application, or mixed as a paste for brush/roller/caulk application.

Abstract: Substantially leachless, agent-encapsulating sol-gel particles, methods of preparing same and products containing same are provided.

Abstract: The present invention provides the use of nanoparticles of a compound of general formula MnXy, where M is (i) a metal selected from the group consisting of Calcium (Ca), Aluminium (Al), Zinc (Zn), Nickel (Ni), Tungsten (W) or Copper (Cu); or (ii) a non-metal selected from the group consisting of Silicon (Si), Boron (B) or Carbon (C); in which n is equal to 1, 2, or 3, and X is (iii) a non-metal selected from the group consisting of Oxygen (O), Nitrogen (N), or Carbon (C); or (iv) an anion selected from the group consisting of phosphate (PO43?), hydrogen phosphate (HPO42?), dihydrogen phosphate (H2PO4?), carbonate (CO3), silicate (SiO42?), sulphate (SO42?), nitrate (NO3?), nitrite (NO2?); in which y is equal to 0, 1, 2, 3 or 4; for use in reducing and/or preventing virus transmission. Articles of protective clothing or filters are provided in which the fibres are coated with said nanoparticles for use in reducing and/or preventing virus transmission.

Abstract: Methods and compositions for producing flowable compositions, e.g. pastes, that set into calcium phosphate products are provided. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a setting fluid to produce the flowable composition. A feature of the subject methods is that the dry reactants include a particulate calcium and/or phosphate reactant having a mean particle size of less than about 8 ?m and narrow size distribution. Also provided are the compositions themselves as well as kits for use in practicing the subject methods. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g., bone defects.