Abstract: Methods of treating autoimmune microvascular conditions using diosmin or diosmetin are described, particularly the treatment of digital ulcers in systemic sclerosis.

Abstract: This disclosure relates for example to meat alternative compositions comprising a plant based meat alternative and a cranberry seed preparation. This disclosure is also related to methods of preparing such meat alternative compositions.

Abstract: Provided herein is a method for improving the health of an intestinal epithelial barrier using Aloe vera. The method may include administering Aloe vera extracts to intestinal epithelial cells. The decolorized aloe extract may be whole leaf extract, whole leaf dry extract, inner leaf dry extract, digested whole leaf extract, digested whole leaf dry extract, digested inner leaf dry extract, or a combination thereof.

Abstract: The present invention provides compositions derived from cranberry including xyloglucan and pectic oligosaccharides, and iridoid terpene glycosides. These compositions can be used in conjunction with antibiotics to synergistically kill bacterial persister cells and inhibit bacterial quiescent phenotypes, thereby improving treatment outcomes in recurrent and other infections.

Abstract: The present invention relates to a novel composition capable of enhancing tannins' ability to adhere to mucous membranes (mucosas) and skin, its use as a therapeutic composition, and products consisting of or comprising said composition.

Abstract: The invention provides a method of isolating one or more compounds present in fruit juice or seed extracts that have anti-microbial activity.

Abstract: Methods of treating autoimmune microvascular conditions using diosmin or diosmetin are described, particularly the treatment of digital ulcers in systemic sclerosis.

Abstract: The present invention relates to the use of collagen hydrolysate for improving endurance performance by increasing mitochondrial activity. Further, the invention relates to the use of collagen hydrolysate for stimulating lipid catabolism, and in particular for reducing body weight, by increasing mitochondrial activity.

Abstract: The present specification relates to an anti-inflammatory composition including a novel quercetin-based compound isolated from a post-fermented tea, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof, and may be widely used in various areas related to anti-inflammation.

Abstract: A nutraceutical formulation used to militate against bone loss, while also facilitating bone growth, is disclosed herein. The nutraceutical formulation used to therapeutically treat humans includes kale, broccoli, mushroom, raisin, and prune. The nutraceutical formulation also omits ingredients that would otherwise diminish bone density or inhibit the inhibitory effects of the other ingredients in mitigating bone loss.

Abstract: The invention relates to therapeutic compositions, solid oral dosage forms, and methods for treating, preventing, or alleviating lower urinary tract symptoms (LUTS), benign prostatic hyperplasia (BPH), erectile dysfunction (ED), urinary incontinence, bladder obstruction, overactive bladder (OAB), underactive bladder, interstitial cystitis, prostatitis, bladder and prostate inflammation, prostate fibrosis or pelvic pain. The therapeutic compositions can comprise cranberry powder enriched in cranberry seeds or cranberry seed meal.

Abstract: The present invention relates to a method for preventing Gram-negative bacterial colonization of an oropharyngeal material, the said method comprising bringing into contact a composition comprising a cranberry-derived proanthocyanidin extract on at least a part of the surface area of the said material.

Abstract: A method for treating a subject suffering from a neurodegenerative disease includes administering at least one triterpenoid which can be obtained from Hedera helix. A method for treating a subject suffering from a neurodegenerative disease includes administering an effective amount of a Hedera helix extract which comprises the triterpenoid. The neurodegenerative disease is preferably but not exclusively Parkinson's disease or Huntington's disease. Methods for extracting the triterpenoid from Hedera helix and a method for inducing autophagy in cells by contacting them with the triterpenoid are also provided. The triterpenoid allows an exceptional induction of autophagy, in particular a significant reduction of the protein level of mutant huntingtin, a significant reduction of the protein level of A53T ?-synuclein, a significant inhibition of the oligomerization of ?-synuclein and a significant inhibition of the inclusion formation of huntingtin via the AMPK-mTOR dependent autophagy inducing pathway.

Abstract: The invention relates to a skin anti-ageing composition. In particular a skin anti-ageing composition comprising myricetin or glycoside thereof, and at least one LXR alpha agonist. By skin ageing is meant the appearance or manifestation of any one or more of wrinkles or sagging, poor skin barrier such as dryness, scalp itch, or uneven skin tone such as age spots.

Abstract: The present invention relates to 5-O-[6?-(3-hydroxy-3-methyl glutarate)?-D-glucoside as a new antioxidant.

Abstract: Therapeutic use of extracts containing proanthocyanidin including treating disorders, e.g., inflammatory disorders, e.g., inflammatory bowel disease, Crohn's disease, ulcerative colitis, indeterminate colitis, microscopic colitis, collagenous colitis, and irritable bowel syndrome. Methods of increasing a subject's immunological resistance to an infection and/or treating the infection. The infection can be, e.g., a bacterial, viral, or fungal infection. The methods can include, e.g., selecting a subject that has, or is at risk of developing, an infection, e.g., a bacterial, viral, or fungal infection, or a combination thereof; providing a composition comprising at least about 10% proanthocyanidin by weight; and administering to the subject an amount of the composition to the subject, to thereby increase a subject's immunological resistance to an infection and/or to treat the infection.

Abstract: Compositions and methods for inducing hair growth and improving hair quality utilizing extracts of blackberry in an amount effective to induce hair growth when applied topically to an area of the skin on which hair growth is desired.

Abstract: The present invention provides compositions having synergistic antioxidant properties in the modulation of Toll-like receptor signaling for the promotion of homeostasis, immunity, energy conservation, protection of neural cells and anti-inflammatory responses, said compositions comprising plant and/or fruit extracts and a natural sweetener with high oxidation potential as defined by ORAC value.

Abstract: A composition prepared from a cranberry hull enzyme-treated composition which reduces or inhibits the adhesion of microorganisms to cells having ?-Gal-(1-4)-Gal terminal oligosaccharide receptors for adhesion.

Abstract: A composition for treatment of urinary tract infection derived primarily from pomegranate and cranberry fruit components is disclosed. The composition may be derived from juices, concentrates, liquid extracts, or powdered extracts, e.g. dehydrated pomegranate juice, of pomegranate and cranberry fruits. The concentration of each of the component (i.e. pomegranate product and cranberry product) in the composition is set such as to achieve optimum synergistic effects by increasing urinary tract anti-adhesion activity.

Abstract: Described are four, novel supercritical fluid extracts of Nigella sativa seeds containing about 0.01 to about 40% (w/w) thymoquinone that can be produced using commercial-scale quantities of N. sativa seeds. These formulations provide antioxidant, thermogenic, anti-inflammatory and other biological activities qualitatively and quantitatively distinct from thymoquinone alone and are useful as dietary supplements or therapeutics for inflammation-related disorders.

Abstract: A botanical composition made from a plurality of plant materials selected from Gota Kola (Centella asiatica), Turmeric Root (Curcuma longa), White Willow (Salix alba), Rosehips (Rosa canina), Hibiscus (Hibiscus sabdariffa), Evening Primrose (Oenothera biennis), and Bilberry (Vaccinium myrtillus), or phytochemicals or extracts or oils derived from the plant materials has beneficial application in addressing retinopathy and recurring peripheral neuropathy. The botanical composition can include a number of additional agents such as antioxidants, benfotiamine, thiamine (vitamin B1), and lipoic acid.

Abstract: Disclosed is a pharmaceutical composition for treating oxidative stress comprising a therapeutically effective amount of a substantially pure compound of pterostilbene and a physiologically acceptable carrier. Pterostilbene is administered in an amount between about 2.5 mg to about 10 mg per kilogram of subject body weight. Also disclosed is a method for increasing a working memory of a subject, the method comprising administrating an effective amount of a substantially pure compound of pterostilbene, wherein the working memory for a subject increase and the therapeutic effectiveness is about 10 mg of pterostilbene per kilogram of subject body weight.

Abstract: A water-soluble anti-inflammatory cream is disclosed. The cream is a composition of between about 7.5% and about 30% by weight of a healing oil; between about 1% and about 6% by weight of an herbal extract; between about 0% and about 3.5% by weight of microencapsulated amino acids; and at least 39.4% by weight water.

Abstract: Compositions and methods for treating diabetes are presented herein. In particular, the present disclosure reaches compositions and methods for treating diabetes utilizing a gastrointestinal microbiome modulating composition.

Abstract: Described herein are compositions comprising a MMP-13 inhibitor, and methods of using the same.

Abstract: A blood lipid lowering agent that functions through a same mechanism as berberine (e.g. berberine, one or more pharmacologically acceptable salts of berberine or a mixture thereof) and a blood lipid lowering agent that functions through a different mechanism than berberine (e.g. phytosterols, phytostanols, esters thereof or mixtures thereof) act synergistically to improve blood lipid profiles, for example, lowering total cholesterol, LDL-C or nonHDL-C, and triglyceride, and increasing the ratio of HDL-C to nonHDL-C. The two may be used in combination to treat or reduce the chance of contracting cardiovascular disease, hyperlipidemia, atherosclerosis, coronary heart disease, angina, cerebrovascular disease, stroke, overweight or obesity, diabetes, insulin resistance, hyperglycemia, hypertension, arrhythmia, diseases of the central nervous system, diseases of the peripheral nervous system and/or inflammation.

Abstract: A new skin care system includes day and night skin cream compositions comprising nutrients and antioxidants for use by children between six months and eighteen years of age. The day skin cream composition provides protection from UV radiation and the night skin cream composition contains no sun protection ingredients and elevated levels of nutrients and antioxidants. A child-friendly bottle for each composition can be used by young children without difficulty. A fragrance included in each composition is popular with children, and the bottle for the day composition has graphics indicating day-time use and the bottle for the night composition has graphics indicating night-time use. The day composition is applied topically each day to the face after tooth-brushing, and the night composition is applied topically to the face each night after tooth-brushing.

Abstract: Described herein are compositions comprising a MMP-13 inhibitor, and methods of using the same.

Abstract: The present invention is generally directed to compositions and methods for amelioration chronic renal failure and related symptoms in domestic animals. In one case, the present invention is directed to a composition for the treatment of chronic renal failure in a domestic animal or symptoms related to chronic renal failure. The composition comprises a Fruit- and Vegetable-Based Additive. In another case, the present invention is directed to a composition for the treatment of chronic renal failure in a domestic animal or symptoms related to chronic renal failure. The composition comprises a Cesium and/or Rubidium salt. In another case, the present invention is directed to a composition for the treatment of chronic renal failure in a domestic animal or symptoms related to chronic renal failure. The composition comprises a Dehydrated Domestic Animal Food and a Phosphate Binder.

Abstract: A formulation to increase the ratio of gastrointestinal microbiota in phylum Bacteroidetes to microbiota of Firmicutes phylum preferably includes about 20-60 mg/kg of body weight of fermentable fiber, about 10-30 mg/kg of body weight of beta glucan and about 20-60 mg/kg of body weight of blueberry extracts or any fruit or berry ingredient preparation containing similar phenolics. This formulation is preferably used to control body weight, body composition, and blood glucose regulation, preferably in humans, and is preferably administered orally, preferably twice per day.

Abstract: This invention provides an agent for inhibiting production of hepatitis C virus with notable anti-HCV activity and without side-effects. The agent comprises a proanthocyanidin polymer composition illustrated in the following the general formula (1), wherein R1 is hydrogen or hydroxyl, R2 is hydroxyl, R3 is hydrogen when R1 is either hydrogen or hydroxyl, but R3 is possibly hydroxyl when R1 is either hydrogen or hydroxyl to the extent that both R1 and R3 being hydroxyl is at most 40 percents in the proanthocyanidin polymer composition said units of flavan-3-ol being bonded each other in any one of three patterns as follows; (i) a bond between carbon at the position 4 and carbon at the position 8, (ii) a bond between carbon at the position 4 and carbon at the position 6, (iii) a bond between carbon at the position 4 and carbon at the position 8, and between carbon, at the position 2 and oxygen at the position 7.

Abstract: A method and composition for reducing the recovery time for a human suffering from mild traumatic brain injury are provided. The composition is a mixture of component supplements that synergistically address the symptoms of the condition and the damage done by the injury.

Abstract: A dietary supplement and method of supplementation comprises a vegetable component consisting essentially of juices extracted from two parts by weight fresh, unpeeled carrots; one part by weight fresh, unpeeled beet root; one part by weight of fresh, unpeeled cucumber; and a selected quantity of aloe vera juice. A cleansing component includes at least one of the following: about 2 fluid ounces (59.1 ml) of lemon juice; about 1.5-2 fluid ounces (44.3 to 59.1 ml) of lime juice; about 1 fluid ounce (29.6 ml) of aloe vera juice; and about 4-6 fluid ounces (118.3 to 177.4 ml) of cranberry juice. The vegetable component is ingested orally twice daily and the cleansing component is ingested orally once daily.

Abstract: Disclosed is a pharmaceutical composition for treating oxidative stress comprising a therapeutically effective amount of a substantially pure compound of pterostilbene and a physiologically acceptable carrier. Pterostilbene is administered in an amount between about 2.5 mg to about 10 mg per kilogram of subject body weight. Also disclosed is a method for increasing a working memory of a subject, the method comprising administrating an effective amount of a substantially pure compound of pterostilbene, wherein the working memory for a subject increase and the therapeutic effectiveness is about 10 mg of pterostilbene per kilogram of subject body weight.

Abstract: A natural soap is made using a herbal medicine decoction. The natural soap includes herbs including lotus roots, lotus leaves, red ginseng, Hippophae rhamnoides leaves and trunk, persimmon leaves, thuja orientalis, ginger, rosemary, black beans, black sesame, aloe, mulberry leaves, Orostachys japonicus, Angelica gigas, green tea, pine needles, mint, pleuropterus multiflorus, blueberry, and Acorus gramineus. A ripening device ripens the herbs in temperatures of 65 to 95° C. for 3 to 15 days, distilled water or soft water is poured onto the herbs, and the herbs mixed with the water are decocted by a decoction maker.

Abstract: Embodiments of the invention relate to fortified food and dietary supplement products which may be administered to produce desirable physiological improvement. In particular, embodiments of the invention relates to the administration of products enhanced with Morinda citrifolia and iridoids.

Abstract: The invention describes stabile anthocyanin compositions, methods to prepare such compositions and also methods of use of such compositions to treat various afflictions. The present invention describes unique compositions of an anthocyanin and a stabilizing compound such that the combination of the two components provides that the anthocyanin does not readily undergo degradation, such as oxidation, pH instability, etc.

Abstract: A daily liquid supplement for ocular and body health containing at least one of lutein, zeaxanthin, meso-zeaxanthin and astaxanthin for a human subject for nutritionally supplementing macular pigments is disclosed. The micronized nutrients in a lipid based emulsion are more efficiently absorbed into the bloodstream than conventional supplement formulations resulting in higher serum levels and increased macular pigment.

Abstract: A new skin care system includes day and night skin cream compositions comprising nutrients and antioxidants for use by children between six months and eighteen years of age. The day skin cream composition provides protection from UV radiation and the night skin cream composition contains no sun protection ingredients and elevated levels of nutrients and antioxidants. A child-friendly bottle for each composition can be used by young children without difficulty. A fragrance included in each composition is popular with children, and the bottle for the day composition has graphics indicating day-time use and the bottle for the night composition has graphics indicating night-time use. The day composition is applied topically each day to the face after tooth-brushing, and the night composition is applied topically to the face each night after tooth-brushing.

Abstract: The invention relates to the use of a Myrica gale plant for producing a herbicidal agent or for preparing a herbicidal composition, and also to the corresponding herbicidal compositions and the herbicidal compositions containing a newly demonstrated herbicidal agent.

Abstract: A water-soluble anti-inflammatory cream is disclosed. The cream is a composition of between about 7.5% and about 30% by weight of a healing oil; between about 1% and about 6% by weight of an herbal extract; between about 0% and about 3.5% by weight of microencapsulated amino acids; and at least 39.4% by weight water.

Abstract: The present invention provides a composition comprising an effective amount of benfotiamine and an effective amount of pyridoxamine in a suitable vehicle for topical application. The present compositions are useful in improving the appearance of aged skin characterized by wrinkles, loss of elasticity, and hyperpigmentation caused by chronoaging and/or photoaging of skin, by inhibiting particularly skin damage resulting from reactive carbonyl species (RCS), glycation of skin proteins, formation of advanced glycation endproducts (AGEs) and formation of advanced lipoxidation endproducts (ALEs).

Abstract: Black currant anthocyanin-containing compositions for foods comprising 1 to 25% by weight of black currant anthocyanin on the basis of solid matters; a process for producing a black currant anthocyanin-containing composition for foods characterized by purifying and concentrating black currant juice employed as a starting material by using a charged reverse osmosis membrane; functional foods and drinks characterized by containing the above compositions for foods; and the above-described compositions for foods and the above-described functional foods and drinks having an effect of improving visual function, a function of improving blood fluidity, and/or a function of lowering blood pressure. The conventional black currant anthocyanin compositions have a low black currant anthocyanin content, strong acidity and poor stability, which makes them unsuitable as additives for foods and drinks.

Abstract: The method comprises steps of: providing a nutraceutical including, in combination, 1.13 to 3 mg lutein and 18.8 to 51.2 mg omega fatty acids and 1.9 to 5.2 mg grape seed extract and 1.9 to 5.2 mg alpha lipoic acid; determining the weight of each dose of the components in the combination based upon an amount per kg body weight of the animal patients; and administering 1 dose of nutraceutical per day to animals suffering from ocular health issues including any degenerative retinal disease and diabetic cataracts and prior to and following cataract surgery for the diminishment and prevention of secondary cataracts.

Abstract: Fortified food and dietary supplement products may be administered to produce desirable physiological improvement. In particular, embodiments of the invention relates to the administration of products enhanced with plant products and iridoids. A study was performed to evaluate the iridoid content, as well as the in vitro and in vivo bioactivities, of a beverage containing noni fruit, Cornelian cherries, and olive leaf extract. The major iridoids present were identified as asperulosidic acid, deacetylasperulosidic acid, oleuropein, morroniside, loganic acid, and loganin In the 2,2-Diphenylpicrylhydrazyl (DPPH) radical scavenging assay, remarkably high in vitro antioxidant activity was observed, with an IC50 of 3.8 ?L/mL. In vivo bioactivities were evaluated in type 2 diabetic Sprague Dawley rats.

Abstract: Provided herein are methods of culturing cells in vitro in order to exploit the biochemical production ability of the cells to make metabolites that are evaluated and harvested for their biological effects. Also provided are systems for evaluating extracts from such cultured cells to characterize their biological activity(s), particularly with regard to impact on health, wellbeing, longevity, DNA maintenance, mitochondrial health and/or biogenesis, and so forth. Biologically active extracts, components thereof, and compositions (such as cosmetic or pharmaceutical preparations) made comprising such, are also provided.

Abstract: The present invention provides antacid compositions and associated methods. In one aspect for example, an antacid composition suitable for delivery to a subject for reducing a digestive condition includes an effective amount of at least one citrate compound, an effective amount of blueberry product, and an effective amount of fruit extract including a member selected from the group consisting of pomegranate extract, bilberry extract, elderberry extract, blueberry extract, and combinations thereof.

Abstract: Compositions and methods of use of annatto extracts [350-450 Dalton molecular weight fraction] including tocotrienols and tocopherols with an appropriate spectrum. This spectrum includes but not limited to low alpha tocopherol, high delta- and gamma-tocols, and mixtures with other extracts [350-450 Dalton molecular weight fraction] like palm and rice and/or nutrients.

Abstract: A new treatment for individuals suffering from type 2 diabetes. The formulation used in the treatment includes a mixture of a thiazoleineione, an insulin, cinnamon bark extract, and at least one synergistic supplement selected from the group consisting of blueberry leaf extract, cranberry extract, kelp extract, sugar sea beet extract, acerola berry extract; ginger root extract, black cherry extract, green tea extract, Irish moss extract, aloe vera extract, and Stevia leaf extract. The thiazoleineione is preferably pioglitazone. The insulin is preferably an Insulin Aspart of rDNA origin. It is preferred that the cinnamon bark extract and synergistic supplement be in the form of a liquid concentrate.