Abstract: The present invention provides a composition comprising (a) an antimicrobial compound of the formula (I) wherein R1 is a fatty acid chain; R2 is a linear or branched alkyl residue having from 1 to 12 carbon atoms; n is an integer from 0 to 10; X? is selected from Br?, I?, Cl? and HSO4; (b) an antimicrobial material selected from lanthionine bacteriocins, tea [Camellia sinensis] extract, hop [Humulus lupulus L.] extract, grape skin extract, grape seed extract, Uva Ursi extract and combinations thereof.

Abstract: Disclosed is an effervescent composition that includes an effervescent agent and cranberry extract, preferably in an amount sufficient to decrease the measurable amount of bacteria present in the urine of an individual having a urinary tract infection.

Abstract: The herbal women's health formula includes a large variety of herbs that are useful in substantially reducing, if not altogether eliminating, a wide range of symptoms specifically related to women.

Abstract: The present invention discloses novel mechanisms in the aging process and describes novel methods for high-throughput screening to identify, detect, and purify agents to be used for improving mitochondrial function, maintaining the cell cycle-arrested state in senescent and post mitotic cells, and thus preventing or treating age-related diseases or disorders associated with accelerated mitochondrial function loss, telomere dysfunction, and/or deterioration of the growth-arrested state. The present invention also discloses a number of compounds or compositions identified from this method. The present invention further provides the use of low doses of rapamycin or its analogs as a mimic of caloric restriction in preventing age-related diseases or disorders.

Abstract: A topical skin care product is provided that contains therapeutic concentrations of turmeric and other constituents which is colorless upon application to the skin. The product can be used for cosmetic, protective, and healing purposes without staining skin or clothing yellow.

Abstract: The treatment and prevention of skin irritations, including diaper rash, is facilitated with the topical application of cranberry anthocyanins in a cosmetically acceptable vehicle.

Abstract: Disclosed is an effervescent composition that includes an effervescent agent and cranberry extract, preferably in an amount sufficient to decrease the measurable amount of bacteria present in the urine of an individual having a urinary tract infection.

Abstract: Compositions including synergistic combinations of ascorbic acid, Indian gooseberry, and additional components for increasing the antioxidant capability of certain target components, such as superfruits, fruits, and other low and/or high antioxidant containing substances. Particular combinations of ascorbic acid, Indian gooseberry extract, one or more citrus bioflavanoids, and one or more fatty acids added to various target components synergistically increases the antioxidant capability of the overall composition over expected values.

Abstract: The present invention comprises a composition with means to inhibit the function of the inflammatory cytokine IL-1 and methods for using this composition to treat inflammatory disease of ocular and adnexal tissues by topical administration. The present invention also discloses devices for delivering this composition to target tissues.

Abstract: There are provided various compounds and compositions comprising polyunsaturated fatty acid monoglycerides and derivatives thereof. These compounds and compositions can be useful as cancer chemopreventive agents. They can also be useful for enhancing solubility of various active agents and enhancing their bioavailability.

Abstract: A topical skin care product is provided that contains therapeutic concentrations of turmeric and other constituents which is colorless upon application to the skin. The product can be used for cosmetic, protective, and healing purposes without staining skin or clothing yellow.

Abstract: A composition for modulating cytokines to regulate an inflammatory or immunomodulatory response. The composition can include at least one of rosehips, blueberry, blackberry, elderberry, cranberry, rosemary, clove, feverfew, nettle root, artichoke, reishi mushroom, olive extract, green tea extract, grape seed extract, resveratrol, Aframomum melegueta, boswellia serrata extract, boswellia forte, ipriflavone, tocotrienols, evening primrose oil, INM-176, borage oil, krill oil, at least one type of xanthophyll (e.g., astaxanthin), green coffee extract and ferulic acid. Specifically, a composition of the invention can include: rosehips and at least one of blackberry, blueberry, elderberry, and optionally krill oil; or rosehips, resveratrol and at least one of Aframomum melegueta and astaxanthin.

Abstract: A composition for modulating cytokines to regulate an inflammatory or immunomodulatory response. The composition can include at least one of rosehips, blueberry, blackberry, elderberry, cranberry, rosemary, clove, feverfew, nettle root, artichoke, reishi mushroom, olive extract, green tea extract, grape seed extract, resveratrol, viniferin, Aframomum melegueta, boswellia serrata extract, boswellia forte, ipriflavone, tocotrienols, evening primrose oil, INM-176, borage oil, krill oil, at least one type of xanthophyll (e.g., astaxanthin), green coffee extract and ferulic acid. Specifically, a composition of the invention can include: rosehips and at least one of blackberry, blueberry, elderberry, and optionally krill oil; or rosehips, resveratrol and at least one of Aframomum melegueta and astaxanthin.

Abstract: This invention describes a comprehensive nutraceutical designed to antagonize major mitigating factors to the degenerative process associated with Parkinson's disease. The formulation is comprised of a primary base of pyruvate, succinate, ?-Ketoglutarate and/or oxaloacetate, niacin/NADH, fruit extracts, anthocyanins, further combined with specific macro/micronutrients, trace elements, amino acids, flavonoids and concentrated plant sources. The nutraceutical contains all natural substances that should mitigate many of the neurodegenerative processes known to be associated with PD. Mechanisms addressed are to prevent the loss of ATP/by 1-methyl-4-phenylpyridinium rotenone, scavenge hydrogen peroxide/O2.

Abstract: A stick lip balm with efficacious amounts of natural moisturizer and organoleptic/sensory attributes of lip feel associated with moisturizers and emollients is provided. The lip balm of the invention comprises at least 90% botanically derived materials and can be formed into a stick sufficiently robust to substantially retain the stick shape under normal conditions of shipping, storage and usage. A method of making the stick lip balm is also provided.

Abstract: The present invention relates to AMPK activation utilizing phytochemicals, natural plant extracts and combinations. Disclosed are methods, compounds, and compositions comprising drugs, medical foods, and dietary supplements for the prevention and treatment of metabolic disorders, in particular obesity, weight gain, insulin resistance syndromes, diabetes, fasting hyperlipidemia and osteoarthritis. More specifically, the invention relates to pharmaceutical therapeutic methods and compositions utilizing phytochemicals, natural plant extracts and combinations to modify myocyte, hepatocyte, adipocyte, cardiac or pancreatic physiology through activation of AMPK.

Abstract: The present invention relates, in particular, to: novel uses of a C-glycoside compound; the use, in a cosmetic composition in particular, of a C-glycoside compound in combination with at least one other skincare ingredient or active agent for improving the appearance and/or the texture of the skin; compositions comprising said combinations; or alternatively, a cosmetic or dermatological assembly comprising at least two separate compositions respectively containing, for one, the C-glycoside compound and, for the other, said cosmetic or dermatological ingredient and/or active agent; and cosmetic methods using said combinations and/or said compositions.

Abstract: A method of treating or preventing diabetes or obesity that comprises administering an antioxidant-enriched composition produced by fermenting fruit extracts with the bacteria Serratia vaccinii. The antioxidant-enriched composition is capable of decreasing plasma glucose levels, increasing circulating adiponectin levels and decreasing hyperphagia in a subject.

Abstract: A product made by a process which results in compositions enriched in total phenols includes purification steps not involving the addition of bisulfite ions. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols, total phenol concentration >12% and exhibiting in vitro COX-2 inhibitory activity enhanced by a factor of at least 2.5 over a standard aspirin dose of 660 ?g/mL.

Abstract: Compositions are disclosed which have as a component thereof an inhibitor of the enzymatic production of 3-deoxyglucosone (3DG) from fructoselysine and/or an inactivator of 3DG, and which are useful for the treatment or prophylaxis of a condition or disease state that is alleviated by inhibiting such 3DG production. Methods of using such compositions, e.g., for improving the appearance, texture and/or elasticity of aging skin, are also disclosed.

Abstract: Isolated cranberry seed oil and components thereof, in a form suitable for use as a foodstuff, dietary supplement, or pharmaceutical composition, are disclosed. The isolated cranberry seed oil or compositions comprising one or a combination of components derived from the cranberry seed oil can be used as anticancer, hypocholesterolemic, antithrombotic, antioxidizing, antiatherogenic, antiinflammatory, and immunoregulatory agents. In addition, the invention features novel methods of extracting cranberry seed oil from cranberry seeds in a form suitable for adding to foodstuffs, dietary supplements, or pharmaceutical compositions.

Abstract: In an embodiment of the present invention, a nutraceutical formula comprising a combination of two or more substances from the group: berry extract, chromium, zinc, trans-resveratrol, l-arginine, chlorophyll, vitamin C and aloe vera combined synergistically to reduce inflammation in mammals suffering from diabetes. In another embodiment of the present invention, a nutraceutical formula comprising a combination of two or more substances from the group: berry extract, chromium, zinc, fr-??s-resveratrol, l-arginine, chlorophyll, vitamin C and aloe vera combined synergistically to enhance wound healing in mammals suffering from diabetes. In an alternative embodiment of the present invention, a nutraceutical formula comprising a combination of two or more substances from the group: berry extract, chromium, zinc, trans-resveratrol, l-arginine, chlorophyll, vitamin C and aloe vera combined synergistically to reduce inflammation in mammals not suffering from diabetes.

Abstract: Black currant anthocyanin-containing compositions for foods comprising 1 to 25% by weight of black currant anthocyanin on the basis of solid matters; a process for producing a black currant anthocyanin-containing composition for foods characterized by purifying and concentrating black currant juice employed as a starting material by using a charged reverse osmosis membrane; functional foods and drinks characterized by containing the above compositions for foods; and the above-described compositions for foods and the above-described functional foods and drinks having an effect of improving visual function, a function of improving blood fluidity, and/or a function of lowering blood pressure. The conventional black currant anthocyanin compositions have a low black currant anthocyanin content, strong acidity and poor stability, which makes them unsuitable as additives for foods and drinks.

Abstract: The present disclosure relates in part to extracts of cranberry (Vaccinium macrocarpon) comprising an enriched amount of certain compounds having anti-infective activity, e.g. antibacterial and/or antifungal activity, e.g. activity against C. albicans. Another aspect of the disclosure relates to combined cranberry and cinnamon extracts. In certain embodiments, these combined extracts have been optimized to control urinary tract infections caused by E. coli, S. aureus and C. albicans. Certain embodiments of the extract are enriched in bioactive compounds that have been shown to inhibit C. albicans adhesion and/or biofilm formation and its growth in vitro. In another aspect of the disclosure, the extracts are enriched in bioactives derived from cranberry and cinnamon that have been shown to inhibit the attachment and the growth of common urinary tract pathogens like E. coli, S. aureus and C. albicans.

Abstract: A novel dietary supplement or therapeutic composition is provided that serves to treat lower urinary tract disorders or to support normal urinary tract function in animals. The supplement comprises a thymoquinone formulation and at least one member of the group consisting of cranberry fruit, cranberry extract, cranberry juice and a pharmaceutical grade methionine.

Abstract: A delivery system and method for delivering soluble dietary fibers in a chewable tablet form which is palatable and demonstrates a high degree of consumer acceptability.

Abstract: Topical anti-oxidant liposomal phytonutrient formulations and methods for their use such as the treatment of skin inflammation and skin-lightening applications.

Abstract: Compositions including a topical steroid, a blend of concentrated botanic seed oils, and a suitable vehicle for topical application to the skin are described. Compositions of the present invention can be used as a therapeutic method for treating skin conditions, including scalp conditions such as dandruff. The compositions are topically administered to the affected area of the skin of a mammal in need of such therapy. The botanic seed oils used in the compositions may be prepared using a cold press method, and may include three or more botanic seed oils. The blend of botanic seed oils may include, for example, red raspberry seed oil, black raspberry seed oil, pomegranate seed oil, blueberry seed oil, pumpkin seed oil, carrot seed oil, blackberry seed oil, grape seed oil, cranberry seed oil, and black cumin seed oil.

Abstract: A pharmaceutical topical spray composition including a topical corticosteroid, an alcohol, a propellant, isopropyl myristate, and a blend of botanic seed oils is described. The blend of botanic seed oils may include three or more botanic seed oils prepared using a cold press method. A method for treating an inflammatory skin condition by administering the pharmaceutical topical spray composition to the skin of a mammal is also described. The pharmaceutical composition is effective in the treatment of inflammatory skin conditions without the need for zinc pyrithione, undecylenic acid, or a detergent.

Abstract: Phytoceutical compositions for the prevention and treatment of circulatory disorders, feminine endocrine disorders, and dermal disorders. A specific combination of extracts of plants is taught, as well as principles for varying the formulations based on categorizing plants into one of three groups, Energy, Bio-Intelligence, and Organization and selecting several plants from each group. Such combinations have synergistic effects, with minimal side effects.

Abstract: The present invention provides compositions and methods for preconditioning, providing neuroprotection to, and/or enhancing the neural recovery of an individual. The compositions include pomegranate extract, blueberry extract, curcumin and/or magnesium citrate, and Omega 3 fatty acids. The compositions can be used in beverages or food products. In preferred embodiments, the compositions are a component of an aqueous beverage, i.e. an energy, sports, or soft drink.

Abstract: A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.

Abstract: A mixture is formulated that is capable of improving a person's well being, lowering the risks of cardiovascular and/or Alzheimer's diseases and/or lowering blood sugar using natural and synthetic ingredients. A mixture of the present invention may be used as a food, a drink, a supplement or potentially a drug. Numerous ratios of ingredients may be formulated to balance flow (viscosity), sediment/uniformity, color, taste, flavor and aroma. Moreover, a method of making certain ingredients soluble in water and/or oil by micro-emulsion and a method encapsulating key ingredient(s) in nano-vessel are described herein.

Abstract: A method is disclosed that prevents, controls and ameliorates urinary tract infections caused by E. coli by administering a therapeutically effective amount of a human dietary supplement composition comprising a cranberry derivative or proanthocyanidin containing concentrate and D-mannose combined in a form suitable for oral consumption. The cranberry derivative or proanthocyanidin containing concentrate comprises from about one percent (1.0%) by weight to about 95 percent (95.0%) by weight on a dry weight basis. The composition is formulated for delivering a D-mannose unit dosage between about 0.5 to about 5.0 grams per dose and further comprising an analgesic or antispasmodic or combination thereof, and optionally a diuretic, and wherein the composition formed from the cranberry derivative or proanthocyanidin containing concentrate, D-mannose are effective together for binding to E. coli to aid in flushing the E. coli from the urinary tract system while preventing binding of E.

Abstract: The invention relates to the use of blueberry extract for the preparation of a therapeutic composition for oral administration for the treatment and prevention of tinnitus.

Abstract: A method is disclosed that prevents, controls and ameliorates urinary tract infections caused by E-coli by administering a therapeutically effective amount of a human dietary supplement composition comprising a cranberry derivative or proanthocyandin containing concentrate and D-mannose combined in a form suitable for oral consumption. The cranberry derivative or proanthocyandin containing concentrate comprises from about one percent (1.0%) by weight to about 95 percent (95.0%) by weight on a dry weight basis. The composition is formulated for delivering, a D-mannose unit dosage between about 0.5 to about 5.0 grams per dose and further comprising a diuretic and wherein the composition formed from the cranberry derivative or proanthocyandin containing concentrate, D-mannose and diuretic are effective together for binding to E-coli to aid in flushing the E-coli from the urinary tract system while preventing binding of E-coli to cells in the urinary tract system.

Abstract: Compositions particularly suitable for preventing or treating urinary tract infections in mammals, especially in humans, comprising a combination of components, the composition comprising an effective amount of: (A) cranberry concentrate, cranberry extract or both; (B) D-mannose; and at least one component selected from the group consisting of: (C) ascorbic acid; (D) bromelain; and (E) inulin. The compositions are preferably in the form of a liquid concentrate such as a beverage drink.

Abstract: The invention relates to compositions containing recycling/transfer proteins for structurally/functionally modified lipids, a lipid depot of structurally non-modified lipids, and non-transferable active ingredients. Such compositions can be used for the engineering of biomembranes, e.g. by external topical application, especially to the skin/mucous membranes. Structurally or functionally, especially oxidatively modified, lipids are removed from the structures containing the same, such as lipid aggregates of the skin, are externally regenerated in a depot, and preferably introduced back into the structures. The invention also relates to the recycling of modified lipids of biomembranes. The inventive compositions are self-regulative and can be especially applied in a cosmetic, cosmetic balneological or dermatological/pharmaceutical manner.

Abstract: The present invention relates to a composition for prophylaxis or treatment of urinary system infection, comprising a matrix metalloproteinase inhibitor. The present invention also relates to a method for prophylaxis or treatment of urinary system infection, comprising administering to a patient in need of such treatment an effective amount of composition comprising a matrix metalloproteinase inhibitor.

Abstract: The treatment and prevention of skin irritations, including diaper rash, is facilitated with the topical application of cranberry anthocyanins in a cosmetically acceptable vehicle.

Abstract: A topical skin care composition with a base skin care composition suitable for application to skin, and blends of botanic seed oils, prepared according to a cold press method. The base skin care composition uses a multivesicular emulsion skin care delivery system as a base skin care composition. A micelle skin care delivery system is another base skin care composition used in the topical composition. The selected base skin care composition has a range of about 99.9% (% w/w) to 98% (% w/w) of the topical skin care composition, and range of about 0.1 (% w/w) to 2% (% w/w) of blends of botanic seed oil having red raspberry seed oil, and plurality of botanic oils selected from the group consisting of the following seed oils: pumpkin seed oil, chardonnay grape seed oil, carrot seed oil, blueberry seed oil, cranberry seed oil, pomegranate seed oil, black cumin seed oil, and black raspberry seed oil.

Abstract: A delivery system and method for delivering soluble dietary fibers in a chewable tablet form which is palatable and demonstrates a high degree of consumer acceptability.

Abstract: Isolated cranberry seed oil and components thereof, in a form suitable for use as a foodstuff, dietary supplement, or pharmaceutical composition, are disclosed. The isolated cranberry seed oil or compositions comprising one or a combination of components derived from the cranberry seed oil can be used as anticancer, hypocholesterolemic, antithrombotic, antioxidizing, antiatherogenic, antiinflammatory, and immunoregulatory agents. In addition, the invention features novel methods of extracting cranberry seed oil from cranberry seeds in a form suitable for adding to foodstuffs, dietary supplements, or pharmaceutical compositions.

Abstract: The disclosure provides oral compositions having at least two botanical active ingredients derived from plants. The oral composition also includes an orally acceptable vehicle to deliver an effective amount of the at least two active ingredients in vivo. The botanical active ingredients provide particularly efficacious antimicrobial (antibacterial, antiviral, and/or antifungal), antioxidant, anti-inflammatory, anti-ageing, and or healing properties to the oral compositions.

Abstract: A Phytoceutical composition for the prevention and treatment of renal disorders is provided. A specific combination of extracts of plants is taught, as well as principles for varying the formulations based on categorizing plants into one of three groups, Energy, Bio-Intelligence, and Organization and selecting several plants from each group. Such combinations have effects, with minimal side effects.

Abstract: The invention relates to Vaccinium fruit extracts, related preparations, production methods and uses.

Abstract: Compositions and methods of use of annatto extracts [350-450 Dalton molecular weight fraction] including tocotrienols and tocopherols with an appropriate spectrum. This spectrum includes but not limited to low alpha tocopherol, high delta- and gamma-tocols, and mixtures with other extracts [350-450 Dalton molecular weight fraction] like palm and rice and/or nutrients.

Abstract: The invention relates to the administration of products enhanced with Morinda citrifolia L. in order to inhibit anaerobes, gram negative bacteria, protozoa and other microbial growth related to various maladies and illnesses which result in detrimental physiological effects.

Abstract: A first extract of lingonberry (Vaccinium vitis-idaea L.) comprising 5-35 wt % of anthocyanin, 20-95 wt % of proanthocyanin, less than 5 wt % of resveratrol, and the balance of other components, a second extract containing 60-98 wt % of resveratrol, and a third extract composed any ratio of comprising of the first and the second extracts. Methods for preparing the first and second extracts, and use of the extracts in preparation of compositions for eliminating oxygen free radicals, anti-aging, weight loss, preventing cardiovascular disease, inhibiting thrombosis, and promoting beauty.

Abstract: A method of treating cancer by targeting two proteases, MMP-9 and cathepsin B is provided. Therapeutic compositions comprising one or more plant extracts that inhibit MMP-9 and/or cathepsin B, which are capable of inhibiting neoplastic and/or endothelial cell migration, tumour growth, tumour-induced angiogenesis and/or metastasis are also provided. The therapeutic compositions of the invention can be used in the treatment of cancer, and, methods of inhibiting tumour growth, tumour metastasis, and/or tumour-induced angiogenesis using the therapeutic compositions alone or in combination with an anti-cancer agent are, therefore, also provided.