Containing Or Obtained From Piper (e.g., Black Pepper, Kava-kava, Etc.) Patents (Class 424/734)
  • Patent number: 10154985
    Abstract: A method for treating a glycoprotein-related disease is disclosed, which comprises: administering a first effective amount of phenol red and a second effective amount of an organic arsenic compound to a subject in need thereof.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: December 18, 2018
    Inventor: Ming-Chang Lu
  • Patent number: 10045541
    Abstract: An anti-microbial composition includes an extract of at least one of Aucklandia lappa Decne and Punica granatum. The extract can be an aqueous ethanol extract. The extract can be formed using the peel of the pomegranate and the root of the Aucklandia lappa Decne. A weight ratio of the Aucklandia lappa Decne and Punica granatum in the composition can range from about 4:1 to about 1:1.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: August 14, 2018
    Assignee: SULTAN QABOOS UNIVERSITY
    Inventors: Sidgi Syed Anwer Abdo Hasson, Ali A. H. Al-Jabri, Khazina Al-Harthy
  • Patent number: 9682048
    Abstract: A multi-component formulation for the treatment, delay, and/or prevention of cognitive decline, including Alzheimer's disease, and/or other neurodegenerative diseases. One embodiment of the multi-component formulation comprises methylsulfonylmethane, at least one energy source component, and at least one of an herbal component or a nutritional component. In one formulation, the energy source component is fructose 1,6-disphosphate. An herbal component of at least one formulation is curcumin. In one further formulation, a nutritional component is selected from the group consisting of docosahexaenoic acid, resveratrol, and blueberry.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: June 20, 2017
    Inventor: Gene S. Rosen
  • Patent number: 9572356
    Abstract: Provided is a fat or oil composition having high oxidative stability even though containing large amounts of eicosapentaenoic acid and docosahexaenoic acid, and having suppressed degradation odor and unpleasant odor derived from a rosemary extract at the time of cooking. The fat or oil composition comprises the following components (A), (B), and (C):(A) a fat or oil in which a total content of eicosapentaenoic acid and docosahexaenoic acid in constituent fatty acids of the fat or oil is from 0.1 to 20 mass % with respect to total constituent fatty acids of the fat or oil; (B) a rosemary extract; and (C) a dill extract, in which a mass ratio of a content of the component (B) to a content of the component (C), [(B)/(C)], is from 2 to 200.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: February 21, 2017
    Assignee: KAO CORPORATION
    Inventor: Yuumi Matsuda
  • Patent number: 9420817
    Abstract: Disclosed is an agent for ameliorating dysphagia containing capsinoid as an active ingredient. Also disclosed is a pharmaceutical composition or food composition containing the agent. The agent, pharmaceutical composition or food can be administered to a subject suffering from dysphagia such as elderly person.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: August 23, 2016
    Assignee: AJINOMOTO CO., INC.
    Inventors: Takae Ebihara, Satoru Ebihara, Yoko Shimagami
  • Patent number: 9381168
    Abstract: The present invention relates to a new use of capsiate or dihydrocapsiate, more particularly to a composition for preventing and treating inflammatory disease, angiogenesis-related disease and autoimmune disease or for suppressing immunity comprising capsiate, dihydrocapsiate or a pharmaceutically acceptable salt thereof as an effective ingredient. The composition and immunosuppressant of the present invention may be used for preventing and treating inflammatory disease, angiogenesis-related disease and autoimmune disease, and for suppressing immunity.
    Type: Grant
    Filed: May 27, 2008
    Date of Patent: July 5, 2016
    Assignee: Catholic University Industry Academy Cooperation Foundation
    Inventors: Dong Heun Shin, Young Guen Kwon, Bo Jeong Pyun, Tae-Yoon Kim
  • Patent number: 9302967
    Abstract: The present invention relates to compounds of general formula 1 for the treatment of bronchial asthma by inhibition of IL-4 or IL-5 pathway inhibition. The present invention also relates to the use of compound of general formula 1 for the treatment of bronchial by inhibition of IL-4 or IL-5 pathway. The present invention also relates to the method of treating asthma by inhibition of IL-4 or IL-5 pathway by administration of compound or said composition through oral, intranasal, route or by inhalation to a mammal in need thereof. Compound of general formula 1 may be used for reducing perivascular and peribronchial inflammation.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: April 5, 2016
    Assignee: Council of Scientific & Industrial Research
    Inventors: Santu Bandyopadhyay, Balaram Ghosh, Parasuraman Jaisankar, Bikas Chandra Pal, Siddhartha Roy, Bholanath Paul, Arjun Ram, Ulaganathan Mabalirajan, Nahid Ali, Arun Bandopadhyay, Aditya Konar, Jayashree Bagchi Chakraborty, Indrani Choudhury Mukherjee, Jaydeep Chaudhuri, Sanjit Kumar Mahato, Anirban Manna, Roma Sinha, Pradyot Bhattacharya, Jayaraman Vinayagam, Deba Prasad Jana, Sushovan Chowdhury
  • Patent number: 9066973
    Abstract: A composition is provided for promoting weight loss. This comprises a component for supporting healthy thyroid function; a component for increasing satiety; a component for inhibiting carbohydrate uptake and usage; a component for increasing calorie expenditure; and a component for increasing fatty acid oxidation therefore improving lean body composition. A method promoting weight loss in a human is also provided. The method comprises the following steps: supporting healthy thyroid function; increasing satiety; inhibiting carbohydrate uptake and usage; increasing calorie expenditure; and increasing fatty acid oxidation therefore improving lean body composition.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: June 30, 2015
    Assignee: NUVOCARE HEALTH SCIENCES INC.
    Inventor: Ryan Jason Foley
  • Patent number: 9066950
    Abstract: Embodiments of the invention relates to pharmaceutical compositions for use in the treatment of pain and inflammation in mammals, including humans, by administering compositions comprising i) an effective amount of an analgesic having an optional anti-inflammatory effect; (ii) an amount of caffeine effective in enhancement of pain relief; and, (iii) an amount of B vitamins effective in enhancement of pain relief.
    Type: Grant
    Filed: March 2, 2010
    Date of Patent: June 30, 2015
    Assignee: GM Pharmaceuticals, Inc.
    Inventor: Odes W. Mitchell
  • Publication number: 20150132280
    Abstract: A human dietary supplement comprises theacrine and optionally other compounds that modulate the effects of theacrine. Uses for the theacrine-containing supplement include improvement of at least one of mood, energy, focus, concentration or sexual desire or a reduction of at least one of anxiety or fatigue.
    Type: Application
    Filed: November 12, 2014
    Publication date: May 14, 2015
    Applicant: ORTHO-NUTRA, LLC
    Inventors: Hector L Lopez, Shawn Wells, Tim N. Ziegenfuss
  • Publication number: 20150125542
    Abstract: A Tie2 activator containing, as an active ingredient, a hawthorn extract, a starfruit extract, a shellflower extract, a lotus extract, a rooibos extract, an Indian date extract, a Chinese quince extract, a Psidium guava extract, a long pepper extract, a Quillaja extract, a Kouki extract, a ginkgo extract, an oyster extract, a turmeric extract, a chrysanthemum extract, a jujube extract, a Chinese wolfberry extract, a chamomile extract, or a Butcher's Broom extract, or any combination thereof.
    Type: Application
    Filed: January 13, 2015
    Publication date: May 7, 2015
    Inventors: Nobuaki OHTO, Akinori KISO
  • Patent number: 9023375
    Abstract: The present invention provides a novel liquid animal repellant composition which is environmentally safe, non-toxic, long-lasting and efficacious against a wide variety of animals such as dogs, cats, raccoons, skunks, mice, rates, squirrels, chipmunks, deer, etc.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: May 5, 2015
    Assignees: Woodstream Corporation, Passion-Krafts Int'l
    Inventors: David L. Anderson, Theodore L. Davidson
  • Publication number: 20150044306
    Abstract: A process for fractionating a plant material to provide isolated extractives, the process includes pretreating the plant material to provide a fluidized plant material, subjecting the pretreated fluidized plant material to high frequency pulses and shear forces without denaturing bioactive aspects of one or more components of the plant material to provide a first liquid fraction having extractives to be isolated and a first fractionated plant material, separating the first liquid fraction having extractives from the first fractionated plant material, and isolating extractives from the first liquid fraction.
    Type: Application
    Filed: August 8, 2014
    Publication date: February 12, 2015
    Inventors: Melvin Mitchell, James Etson Brandenburg, JR.
  • Patent number: 8945636
    Abstract: A stabilized formulation for skin care, wound care and/or other tissue healing applications and methods for making the same is described. The stabilized formulation stabilizes omega-3 polyunsaturated fatty acids and is constituted of the omega-3 polyunsaturated fatty acids in combination with tocopherol (Vitamin E), ascorbic acid (Vitamin C), herb extract, and a fat-soluble antioxidant. Methods for making and using the stabilized formulation are also described.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: February 3, 2015
    Assignee: Kerecis EHF
    Inventors: Gudmundur Fertram Sigurjonsson, Biljana Ilievska, Baldur Tumi Baldursson
  • Publication number: 20140370095
    Abstract: A beverage composition for weight loss is provided which includes cayenne pepper; a palate enhancing agent selected from the group consisting of fruits, herbs, vegetables and mixtures thereof, the agent including pulp of the fruits, the herbs, the vegetables or the mixtures thereof; a least two spices selected from the group consisting of black or white pepper, ginger, cinnamon, mustard seed and mixtures thereof; and water in an amount from 80 to 99% by weight of the composition; and wherein the composition has a total calorie content from 0 to 100 based on 100 gram of the composition.
    Type: Application
    Filed: May 30, 2014
    Publication date: December 18, 2014
    Inventor: Matthew Watson
  • Patent number: 8895075
    Abstract: A herbomineral composition for the treatment of sickle cell disease is described in the present invention. The herbo mineral composition include some herbal ingredients such as Jaiphal, Sunthi, Jivanti, Haritaki, Guduchi, Shatavari, Dadima, Pippali, along with the therapeutic minerals such as Abrakha Bhasma and Loha Bhasma at suitable concentrations to obtain synergistic anti sickling activity. The composition exhibited up to 60-87% antisickling activity on RBCs in ‘vitro’ at various concentrations. Patients treated with this composition found relief from most of the severe symptoms of sickle cell disease and sickle cell anemia, and had excellent improvement in quality of life.
    Type: Grant
    Filed: September 16, 2008
    Date of Patent: November 25, 2014
    Inventor: Atul M. Desai
  • Publication number: 20140342009
    Abstract: The present disclosure relates to non-acidic extracts or fractions selected from a Boswellia low polar gum resin extract fraction (BLPRE), a Boswellia volatile oil fraction (BVOIL), and a Boswellia oil fraction (BOIL) and their compositions. BLPRE, BOIL, and BVOIL are each derived from the gum resin of a Boswellia species. These compositions are useful for improving mental condition, enhancing brain functions such as cognition, memory, learning, communication and brain health, for treating impaired memory, and for preventing, control or treating memory and cognition related disorders/diseases. Additionally, BOIL, BVOIL, and mixtures of BOIL and BVOIL are useful for enhancing the bioavailability of a biological agent.
    Type: Application
    Filed: August 5, 2014
    Publication date: November 20, 2014
    Inventors: Ganga Raju GOKARAJU, Rama Raju Gokaraju, Venkata Kanaka Ranga Raju Gokaraju, Trimurtulu Golakoti, Kiran Bhupathiraju, Venkata Krishna Raju Alluri
  • Publication number: 20140322198
    Abstract: The invention relates to an active ingredient and/or to a composition having beneficial effect on neurological and cognitive functions.
    Type: Application
    Filed: November 29, 2012
    Publication date: October 30, 2014
    Inventors: Sybille Buchwald-Werner, Hajime Fujii
  • Publication number: 20140301960
    Abstract: The present invention relates to a skin composition which has an excellent effect on smoothing or repairing wrinkles. The composition comprises Palmitoyl Tripeptide-38 (Palmitoyl-Lysyl-Dioxymethionyl-Lysine) and Piper nigrum (Pepper) seed Extract which combination has been found to result in a synergistic effect on hyaluronan synthase 1 (HAS1) mRNA expression in human fibroblasts. The hyaluronan synthase is responsible for the synthesis of hyaluronan (hyaluronic acid) in skin. Hyaluronic acid is a constituent of the extracellular matrix of the skin and responsible for space filling, tissue repair and retention of moisture.
    Type: Application
    Filed: November 14, 2013
    Publication date: October 9, 2014
    Inventors: Muriel Pujos, Dorothee Bernini, Cecile Robert, Olivier Doucet
  • Publication number: 20140294998
    Abstract: Disclosed herein is synergistic herbal composition comprising extracts of herbal ingredients of Tribulus terrestris, Withania somnifera, Curculigo orchioides, Mucuna pruriens, Asparagus adscendens, Asteracantha longifolia, Asphaltum, and optionally the extracts of Piper longum and Anagclus pyrethrum for the treatment of disorders associated with Male Sexual Dysfunction.
    Type: Application
    Filed: June 13, 2014
    Publication date: October 2, 2014
    Inventors: Latha CHAUDHARY, Rekha PATEL, Mughda KULKARNI, Navneet SONAWANE
  • Patent number: 8840938
    Abstract: For enhancing bioavailability, a composition is administered comprising a Transient Receptor Potential cation channel subfamily V member 1 (TRPV1) agonist with a combined Scoville Heat Unit (SHU) milligram (mg) dose in the range of 280,000 to 400,000 SHU mg.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: September 23, 2014
    Inventor: W. Matthew Warnock
  • Publication number: 20140271945
    Abstract: A method of detecting the presence or absence of a disease in a patient wherein said disease is accompanied by deficient levels of S-adenosylmethionine comprising: identifying a patient that is suspected of having said disease or is at risk of having said disease; obtaining a biological sample from said patient; determining the level of S-adenosylmethionine in said biological sample using an antibody derived from a hapten analog of S-adenosylmethionine; and correlating the level of S-adenosylmethionine in said biological sample with the presence or absence of said disease. The invention also provides methods for measuring SAH which is used to determine the methylation index (ratio of SAM/SAH) in biological fluids which is indicative of the health status of an individual.
    Type: Application
    Filed: March 18, 2014
    Publication date: September 18, 2014
    Inventors: Xiujuan Hao, Isaac A. Angres
  • Patent number: 8821948
    Abstract: A medicinal composition comprising an apportioned combination of at least eight essential oils selected from the group consisting of calophyllum inophyllum, citrus aurantium, eucalyptus globulublus, eugenia caryophyllata, foeniculum vulgare, helichrysum angustifolia, juniperus virginiana, lavendula officinalis, muristica fragrans, ocimum basilicim, pinus sylvestrius, piper nigrum, rosemarinus officinalis, salvia officinalis lamiacae, salvia sclarea and zingiber officinale. When configured for topical dermal application, this composition has been shown to be therapeutically effective at relieving pain.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: September 2, 2014
    Inventor: Steva A. Komeh-Nkrumah
  • Publication number: 20140234446
    Abstract: The present invention provides a novel liquid animal repellent composition which is environmentally safe, non-toxic, long-lasting and efficacious against a wide of animals such as dogs, cats, raccoons, skunks, mice, rats, squirrels, chipmunks, deer, etc.
    Type: Application
    Filed: February 25, 2014
    Publication date: August 21, 2014
    Applicant: Woodstream Corporation
    Inventors: David L. Anderson, Theodore L. Davidson
  • Publication number: 20140205688
    Abstract: The present invention relates to a stimulating agent comprising a pungent component having astringency, a stimulating composition including the agent, as well as a flavor or fragrance composition, a food, a drink, an oral care product and an external skin preparation containing the agent or the composition, and also relates to the use of a pungent component having astringency as a stimulating agent. Examples of the pungent component having astringency include a plant extract of Asteraceae Spilanthes, Rutaceae Zanthoxyium, Rutaceae Fagara, or Piperaceae Piper, or an amide derivative represented by general formula (1) (where R1 represents an alkenyl group having 2 to 12 carbon atoms which may be substituted by a methylenedioxyphenyl at the end, R2 and R3 may be the same or different from each other and each are a hydrogen atom or a lower alkyl group in which a hydroxyl group may be substituted, and R2 and R3, together with the nitrogen atom adjacent thereto, may form a heterocyclic ring).
    Type: Application
    Filed: May 29, 2012
    Publication date: July 24, 2014
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Kaori Takahashi, Miyuki Takayanagi
  • Publication number: 20140186473
    Abstract: The present invention relates to a food composition, and to a pharmaceutical composition, which exhibit anti-obesity effects by means of a thermogenesis produced by an activity of a UCP of fat cells, which exhibit anti-diabetes effects by means of an improved insulin resistance, increase muscle mass, and improve capacity for exercise. More particularly, the present invention relates to a novel use of a composition containing extracts of piper retrofractum, and to the food composition or pharmaceutical composition which exhibit anti-obesity effects by means of decreased body weight and body fat, exhibit anti-diabetes effects by means of ameliorated insulin resistance through the reduction of blood glucose and blood insulin, increase muscle mass by increasing an energy source being supplied to the muscles, and improve the capacity for exercise including increased endurance.
    Type: Application
    Filed: May 31, 2012
    Publication date: July 3, 2014
    Applicants: INDUSTRY-ACADEMIC COOPERATION FOUNDATION YONSEI UNIVERSITY, CJ CHEILJEDANG CORP.
    Inventors: Kyung-Jin Kim, Min-Sun Kim, Jae-Kwan Hwang
  • Publication number: 20140161763
    Abstract: The methods, kits, and products for controlling a target insect population are disclosed in which a non-host plant containing a toxin and a chemical attractant known to attract the target insect is treated with chemical attractant from a plant of interest. The chemical attractant induces the target insect to lay eggs on the non-host plant. The resulting offspring die of starvation from refusing to feed on the non-host plant. The non-host plant and plant of interest contain at least one common chemical. The methods, kits, and products for controlling a target insect population using an extract from a non-host plant are also disclosed. The non-host plant extract is applied to the plant of interest, and when ingested or applied directly to the target insect, kills the target insect or causes it to develop with deformities.
    Type: Application
    Filed: January 28, 2011
    Publication date: June 12, 2014
    Applicant: University of the West Indies, a Regional Institution, established by Royal Charter
    Inventors: Trevor Herbert Yee, Charah Tabetha Watson, Eric Garraway, Dwight Robinson, Nemoi Nastassia Sri Garcia Chisholm
  • Patent number: 8691298
    Abstract: A stabilized formulation for skin care, wound care and/or other tissue healing applications and methods for making the same is described. The stabilized formulation stabilizes omega-3 polyunsaturated fatty acids and is constituted of the omega-3 polyunsaturated fatty acids in combination with tocopherol (Vitamin E), ascorbic acid (Vitamin C), herb extract, and a fat-soluble antioxidant. Methods for making and using the stabilized formulation are also described.
    Type: Grant
    Filed: October 24, 2013
    Date of Patent: April 8, 2014
    Assignee: Kerecis EHF
    Inventors: Gudmundur Fertram Sigurjonsson, Biljana Ilievska, Baldur Tumi Baldursson
  • Publication number: 20140093592
    Abstract: The present invention is directed to methods for the treatment of treatment-refractory depression or treatment-resistant depression comprising administering to a patient in need thereof, a therapeutically effective amount of esketamine as mono-therapy or as combination therapy with at least on antidepressant.
    Type: Application
    Filed: December 5, 2013
    Publication date: April 3, 2014
    Applicant: Janssen Pharmaceutica NV
    Inventors: Jaskaran Singh, Lodewijk Ivo Caers
  • Publication number: 20140050805
    Abstract: A composition, including: (A) Panax notoginseng; and at least one of (B) a Piper longum extract and (C) vitamin B1, a salt thereof or a derivative thereof.
    Type: Application
    Filed: April 2, 2012
    Publication date: February 20, 2014
    Applicant: Lion Corporation
    Inventors: Hiroaki Kambayashi, Noriyuki Suzuki, Michiaki Murakoshi
  • Publication number: 20140044810
    Abstract: Use of amide compounds represented by formula (I), for preventing or reducing settlement and/or fouling of marine fouling organisms on a surface of a submerged object is provided, wherein “-A-” has a formula -(CnH2(n?m))- which is either unsubstituted or substituted by one or more C1 to C4 alkyls, and wherein the formula -(CnH2(n?m))- represents a divalent alkyl, or a divalent alkenyl having one or more double bonds, n is 1 to 15, m is 0 to 4, and 2(n?m)=2, and R is selected from piperidinyl, pyrrolidinyl, isobutylamino, piperazinyl or morpholinyl. Amide compounds of formula (I), a category of antifouling compounds, can be either isolated from natural resources or synthesized, which are nontoxic and environmental-friendly.
    Type: Application
    Filed: April 17, 2012
    Publication date: February 13, 2014
    Applicants: YUNNAN UNIVERSITY OF NATIONALITIES, THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Peiyuan Qian, Xiangzhong Huang, Ying Xu, Yu Zhang, Yue Him Wong, Yan Yin, Zhuang Han
  • Publication number: 20130287869
    Abstract: The present invention provides a novel liquid animal repellant composition which is environmentally safe, non-toxic, long-lasting and efficacious against a wide variety of animals such as dogs, cats, raccoons, skunks, mice, rates, squirrels, chipmunks, deer, etc.
    Type: Application
    Filed: June 28, 2013
    Publication date: October 31, 2013
    Inventors: David L. ANDERSON, Theodore L. DAVIDSON
  • Patent number: 8568795
    Abstract: A stabilized formulation for skin care, wound care and/or other tissue healing applications and methods for making the same is described. The stabilized formulation stabilizes omega-3 polyunsaturated fatty acids and is constituted of the omega-3 polyunsaturated fatty acids in combination with tocopherol (Vitamin E), ascorbic acid (Vitamin C), herb extract, and a fat-soluble antioxidant. Methods for making and using the stabilized formulation are also described.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: October 29, 2013
    Assignee: Kerecis EHF
    Inventors: Gudmundur Fertram Sigurjonsson, Biljana Ilievska, Baldur Tumi Baldursson
  • Patent number: 8557310
    Abstract: Compositions and methods are described for delaying the onset of the symptoms of Alzheimer's disease in humans. The compositions can include curcumin, piperine, oleic acid, oleanolic acid, ursolic acid, galantamine, and huperzine A, among other compounds. Curcumin is an antioxidant, while galantamine and huperzine A inhibit the activity of acetylcholinesterase in the brain. Piperine and oleic acid increase the bioavailability and gastrointestinal absorption of curcumin, galantamine, huperzine A, and other nutrients. The composition can also include at least one of phytic acid, piracetam, aniracetam, or indium.
    Type: Grant
    Filed: September 19, 2011
    Date of Patent: October 15, 2013
    Inventor: Stephen C. Perry
  • Publication number: 20130259952
    Abstract: A Tie2 activator containing, as an active ingredient, a hawthorn extract, a starfruit extract, a shellflower extract, a lotus extract, a rooibos extract, an Indian date extract, a Chinese quince extract, a Psidium guava extract, a long pepper extract, a Quillaja extract, a Kouki extract, a ginkgo extract, an oyster extract, a turmeric extract, a chrysanthemum extract, a jujube extract, a Chinese wolfberry extract, a chamomile extract, or a Butcher's Broom extract, or any combination thereof.
    Type: Application
    Filed: May 30, 2013
    Publication date: October 3, 2013
    Inventors: Nobuaki OHTO, Akinori KISO
  • Publication number: 20130251826
    Abstract: The present invention is directed to the use of extracts or of extract compounds from Piper cubeba L. as active components in a medicament for the treatment of cancer. The invention also relates to a method for the preparation of a dry extract from the fruit of Piper cubeba L.
    Type: Application
    Filed: February 28, 2013
    Publication date: September 26, 2013
    Inventors: Matthias-Heinrich Kreuter, Jian Ying Yam, Karin Berger-Buter
  • Publication number: 20130236573
    Abstract: The present invention is directed to methods for the treatment of treatment-refractory depression or treatment-resistant depression comprising administering to a patient in need thereof, a therapeutically effective amount of esketamine as mono-therapy or as combination therapy with at least on antidepressant.
    Type: Application
    Filed: March 12, 2013
    Publication date: September 12, 2013
    Inventors: Jaskaran Singh, Ivo Caers
  • Patent number: 8496975
    Abstract: The present invention relates to compositions comprising benzophenanthridine alkaloids, benzofuran compounds and catechin polyphenols, which are useful in the treatment and prevention of infections of the oral cavity.
    Type: Grant
    Filed: April 6, 2009
    Date of Patent: July 30, 2013
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana, Andrea Giori, Paolo Morazzoni, Antonella Riva, Massimo Ronchi
  • Publication number: 20130136809
    Abstract: The invention discloses biologically active ingredient(s) selected from 7-hydroxyfrullanolide, its analogs, the ex-tract(s) and fraction(s) standardized to 7-hydroxyfrullanolide or its analogs or both or mixtures thereof or their composition(s) for the prevention, control and treatment of one or more obesity, overweight, metabolic syndrome, diabetes and other metabolic disorders or for producing lean body mass in a warm blooded animal in need thereof.
    Type: Application
    Filed: January 28, 2013
    Publication date: May 30, 2013
    Applicant: LAILA NUTRACEUTICALS
    Inventor: LAILA NUTRACEUTICALS
  • Patent number: 8445033
    Abstract: The invention provides a formulation for the prevention and treatment of bacterial infections by administering an effective amount of the formulation comprising an extract of at least one plant selected from Allium sativum, Acorus calamus, Alstonia scholaris, Carissa spinarum, Cissampelos pareria, Chenopodium ambrosioides, Moringa olifera, Paederia foetida, Shorea robusta, Piper nigrum, Pueraria tuberosa, Ocimum sanctum, Terminalia bellirica, Tinospora cordifolia and Zingiber officinale, and a combination thereof. The invention also provides a process for preparing and method of using the same.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: May 21, 2013
    Inventor: Ram Chander Vaidya
  • Patent number: 8404286
    Abstract: The present invention relates to a method for the preparation of a dry extract from the fruit of Piper cubeba L., which characterized in that, in a first step, the fruit of Piper cubeba L. either is subjected to a steam distillation for the removal of essential oils and the distillate is removed or extracted at least once with a lipophilic phase and the lipophilic extract or extracts are removed; in a second step, the fruit, so treated, is extracted at least once either with at least one alcohol or with a mixture of at least one alcohol and water; and, in a third step, the extracted fruit parts are removed and an auxiliary material is added to the extract so obtained, which is then concentrated to a thick extract with an alcohol concentration of 0.1 to 10% (w/w), then dried and recovered.
    Type: Grant
    Filed: August 15, 2008
    Date of Patent: March 26, 2013
    Assignee: Viridis Pharmaceutical Limited
    Inventors: Matthias-Heinrich Kreuter, Jian Ying Yam, Karin Berger-Buter
  • Patent number: 8404246
    Abstract: A nutritional supplement includes the primary ingredients: N-acetyl D-glucosamine, cracked cell wall Green Chlorella, Licorice Root Extract, and Potassium Citrate, as well as secondary ingredients: Zinc L-Carnosine, Gamma-Oryzanol and Capsaicin, that improves the bodies uptake, utilization and over-all bioavailability of exogenous target protein fractions (TPF) including but not limited to: glycoproteins, (such as glucosamine) protein isolates as amino acids, glycosaminoglycans (GAG) (including proteoglycans, and mucopolysaccharides), and polysaccharides such as hyaluronic acid (hyaluronan). The biochemical interactions of the composition improves zeta potential for TPF incorporation in the body through direct and indirect interaction with primary cellular and digestive sites of multiple species.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: March 26, 2013
    Inventor: Shawn Madere
  • Patent number: 8377449
    Abstract: An herbal cleanse formulation comprising five different herbal teas: a parasite tea, an intestinal tea, a detoxifying tea, a tonifying tea, and a relaxing tea. The parasite tea comprises areca seed, black plum, Sichuan pepper, and daikon radish. The intestinal tea comprises mountain hawthorn berry, magnolia bark, senna leaf, aloe, prunus, bitter orange, rhubarb, and licorice. The detoxifying tea comprises cyperus, Chinese angelica, trichosanthes, honeysuckle, forsythia, burdock fruit, dandelion, gardenia, coptis, and mustard seed. The tonifying tea comprises goji berries, red reishi, rehmannia, polygonum, astragalus, ginseng, codonopsis, and schizandra. The relaxing tea comprises ginger, lily bulbs, mimosa tree bark, acorus, sour jujube seeds, yuan zhi, and mint. The herbal cleanse formulation are to be taken at specific times of the day for a determined number of days in a specific protocol in conjunction with a vegan alkalinizing diet and incorporating Kundalini yoga.
    Type: Grant
    Filed: February 7, 2011
    Date of Patent: February 19, 2013
    Inventor: Tatianna Sanabria
  • Patent number: 8372452
    Abstract: An oral herbal composition comprising a therapeutically effective amount of an extract derived from the berries of a plant, Piper cubeba, wherein the composition is provided for use in the treatment of oral candidiasis (oral thrush). The oral herbal composition can be formulated in the form of a candy, a chewable tablet and an oral gel. The herbal composition exhibits antifungal activity against azole resistant strains of Candida albicans. The herbal composition is safe to administer and has improved patient compliance.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: February 12, 2013
    Assignee: Piramal Life Sciences Limited
    Inventors: Vijay Singh Chauhan, Kavita Sujeet Salkar
  • Publication number: 20130017280
    Abstract: The present invention provides a composition for accelerating a change in muscle type, increasing the amount of muscle, strengthening muscle, enhancing athletic abilities, reducing lipids, suppressing the accumulation of lipids, lowering blood sugar, controlling body weight or lowering body weight, containing a PPAR-? promoter, an AMPK promoter and a PGC1-? promoter as an active ingredient
    Type: Application
    Filed: April 6, 2011
    Publication date: January 17, 2013
    Applicant: AMOREPACIFIC CORPORATION
    Inventors: Si Young Cho, Ji Hae Lee, Il Hong Bae, Min Jeong Song, Hyeon Ju Yeo, Dae Bang Seo, Wan Gi Kim, Sang Jun Lee
  • Publication number: 20130004600
    Abstract: A liquid animal repellent composition having a liquid phase and an oil phase, the composition having oleoresins of capsicum, black pepper and rosemary along with surfactants and preservatives. A pH adjuster is also utilized.
    Type: Application
    Filed: June 30, 2011
    Publication date: January 3, 2013
    Inventor: Theodore Davidson
  • Publication number: 20130004601
    Abstract: A dietary supplement for regulating the appetite of an individual is described. The dietary supplement comprises at least one mechanical satiety regulator, and at least one chemical satiety inducer, and may additionally comprise at least one thermogen, and/or at least one side effect remover. The dietary supplement induces satiety based on a combination of occupying part of the volume of the stomach, inducing sending signals to the brain in respect of satiety. Furthermore the dietary supplement may maintain or increase metabolism and reduce side effects such as the amount of produced flatulence. The dietary supplement may comprise fibre, whey, plant parts from plants e.g. of the genus Capsicum and plant parts from a species e.g. of the genus Mentha.
    Type: Application
    Filed: November 26, 2010
    Publication date: January 3, 2013
    Inventors: Soren Vedel Saaby Nielsen, Claude Teisen-Simony
  • Publication number: 20120263808
    Abstract: For enhancing bioavailability, a composition is administered comprising a Transient Receptor Potential cation channel subfamily V member 1 (TRPV1) agonist with a combined Scoville Heat Unit (SHU) milligram (mg) dose in the range of 280,000 to 400,000 SHU mg.
    Type: Application
    Filed: April 13, 2012
    Publication date: October 18, 2012
    Inventor: W. Matthew Warnock
  • Publication number: 20120251465
    Abstract: The present invention has discovered that flavone glycosides represented by Formula I set forth below have unexpected and advantageous flavor enhancement and modification properties: wherein R1 is selected from the group consisting of H and CH3, R2 is selected from the group consisting of H and OH, and R3 is a 7-O-glycoside. Thus, the flavone glycosides of the present invention can be used to enhance or modify the flavor of orally consumable compositions, such as foodstuff, chewing gums, dental and oral hygiene products, and medicinal products.
    Type: Application
    Filed: April 1, 2011
    Publication date: October 4, 2012
    Inventors: Kathryn Bardsley, Bryan Scott Delchamps, Zhihua Liu, Neelima Mannava, Hou Wu
  • Publication number: 20120251637
    Abstract: The present invention relates to an abuse-proofed, thermoformed dosage form containing, in addition to one or more active ingredients with abuse potential optionally together with physiologically acceptable auxiliary substances, at least one synthetic or natural polymer with a breaking strength of at least 500 N and to a process for the production thereof.
    Type: Application
    Filed: June 14, 2012
    Publication date: October 4, 2012
    Applicant: GRUENENTHAL GMBH
    Inventors: Johannes BARTHOLOMÄUS, Heinrich KUGELMANN, Elisabeth ARKENAU-MARIC