Abstract: Described herein are methods of treating pyruvate kinase deficiency (PKD), sickle cell disease or thalassemia with mitapivat or a pharmaceutically acceptable salt thereof, or use of the drug for the treatment of these conditions, in combination with or in the absence of with a secondary drug, such as an inducer or an inhibitor of cytochrome P450. Various doses and dosing regimens of mitapivat in monotherapy and in concomitant medications are described.

Abstract: Disclosed are powder solid compositions including a hydroalcoholic extract of Bergamot fruit (Citrus aurantium var. bergamia) and at least one phospholipid. Also disclosed is a process for the preparation of the compositions. The compositions are useful for the prevention and/or treatment of dysmetabolic syndromes, dyslipidemias and type 2 diabetes.

Abstract: An advantageous deodorizing composition comprising at least one zinc carboxylate salt and aluminium chlorohydrate is provided, as well as a deodorant consumer product comprising the same. Furthermore, a method of suspending aluminium chlorohydrate in an at least essentially anhydrous solvent is provided, as well as a method of preventing clumping of aluminium chlorohydrate in a deodorizing composition or a deodorant consumer product and a method of preventing clogging of a nozzle of a deodorant spray containing a deodorizing composition.

Abstract: Leave-on compositions to be applied to the skin, which after five minutes post-application provides an improved low residue level, where the composition includes an emulsifier having a particular HLB value and an emollient present in a weight amount that is equal to or greater than the weight amount of the emulsifier.

Abstract: A topical composition including an extract of Allium species, an extract of Citrus species, an extract of Paullinia species and an extract of Theobroma species is used for improving and/or increasing and/or stimulating and/or promoting and/or inducing the pigmentation of hair and/or hairs.

Abstract: A topical mosquito control product includes active and inert ingredients. The active ingredients include natural materials and may include soybean oil, cinnamon oil, clove oil, thyme and geraniol. The inert ingredients include natural materials and may include bee's wax, sunflower oil, triethyl citrate, water, vanillin, steric acid, xanthan gum and lecithin.

Abstract: The purpose of this invention is to find a novel fragrance component effective for prevention or control of swelling, lymphedema, skin aging or obesity from the viewpoint of activation of lymph vessel function by promotion of the expression of VEGFC. This invention provides a swelling improving agent, lymph vessel activator and VEGFC production promoter characterized by containing one or a plurality of components selected from the group consisting of rose oxide, citronellyl acetate and niaouli oil.

Abstract: The present invention is directed to mixtures comprising sabadilla alkaloids and at least one essential oil and methods of controlling pests including insects, mites and nematodes by application of mixtures comprising sabadilla alkaloids and at least one essential oil.

Abstract: Several embodiments disclosed herein relate to formulations having antimicrobial and/or sanitizing effects, and uses of the same. In particular, the formulations and methods of using same provide, in several embodiments, an immediate and a persistent antimicrobial effect against a broad spectrum of microorganisms.

Abstract: The invention relates to the use of a composition for the antimicrobial and/or antioxidative treatment of biofilms in water-containing liquids, comprising: (a) a micelle-forming solubilizate which comprises at least one plant extract, at least one emulsifier with an HLB number of 8 to 18, and water, and (b) at least one biodegradable antimicrobial agent selected from the group consisting of peroxides, including peroxycarboxylic acids and H2O2, hypochlorites, hypochlorous acid and a combination thereof.

Abstract: Insect repellants are disclosed. Methods of making and using insect repellants are also disclosed.

Abstract: Disclosed are a cognitive function improvement agent comprising vitamin A, vitamin B components (B1, B2, B6, and B12), vitamin C, vitamin D, vitamin E, zinc, magnesium, pantothenic acid, biotin, and folic acid as active ingredients, and a method for improving cognitive functions, comprising administering vitamin A, vitamin B components (B1, B2, B6, and B12), vitamin C, vitamin D, vitamin E, zinc, magnesium, pantothenic acid, biotin, and folic acid to a mammal.

Abstract: The present invention relates generally to methods of extraction and processing of polymethoxylated flavone (“PMF”) powder from Ortanique peels for commercial application.

Abstract: The invention of the present Application provides a standardized method to obtain an extract and the extract from leaves of Swinglea glutinosa , wherein the method yields an amount of extract that is about 60% the weight of the Swinglea glutinosaleaves.

Abstract: Described herein are methods for treating and preventing graft versus host disease using ACK inhibitors. The methods include administering to an individual in need thereof an ACK inhibitor such as ibrutinib for treating and preventing graft versus host disease.

Abstract: A pharmaceutical two-phase admixture for topical application, transdermal or transmucosal, characterized by components in two phases, a liquid and a solid, adapted for topical application, transdermal or transmucosal, to various skin and/or mucosal surface areas of the body is disclosed. The solid phase is comprised of one or more bio-identical hormones and the liquid phase is comprised of one or more excipient carrier oils. The bio-identical hormone component is comprised of one or more of Bi-Est, testosterone, progesterone, and dehydroepiandrosterone. The excipient carrier oil component is comprised of one or more of jojoba oil, evening primrose oil, and borage seed oil. The pharmaceutical admixture is especially useful in a regime of hormone replacement therapy.

Abstract: Disclosed are pressurized surface treatment compositions which impart a microbicidal benefit to treated surfaces which compositions comprise (or in certain preferred embodiments may consist essentially of, or may consist of): a zinc ion source material which releases zinc ions into the treatment composition, preferably a source of Zn++ ions, at least lower alkyl aliphatic monohydric alcohol which independently of other constituents present exhibits a microbicidal effect, a propellant; and, water. The compositions may further optionally include one or more further optional constituents such as a detersive surfactant and/or minor amounts of one or more constituents which impart one or more advantageous technical or aesthetic benefits to the compositions, including one or more detersive surfactants wherein the compositions have pH of at least 5.

Abstract: A method for treatment of virus-based diseases of the skin, in particular, herpes simplex virus type-1 and herpes zoster, which comprises topically administering to the skin of a subject suffering from a virus-based disease of the skin a therapeutically amount of an aqueous, aqueous/alcohol, or natural plant oil extract of dandelion.

Abstract: A method for treatment of virus-based diseases of the skin, in particular, herpes simplex virus type-1 and herpes zoster, which comprises topically administering to the skin of a subject suffering from a virus-based disease of the skin a therapeutically amount of an aqueous, aqueous/alcohol, or natural plant oil extract of dandelion.

Abstract: The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.

Abstract: The present invention relates to a method of pre-rinsing laundry and treating other surfaces employing a composition that can kill bedbug eggs. The composition includes an anionic compound and is at pH just above neutral, e.g., about 7 to about 9.

Abstract: A pesticidal/ovicidal composition comprising: (a) 50-99.9 parts by mass of a triglyceride containing not less than 50% of oleic acid as a fatty acid component; (b) 0.1-20 parts by mass of a nonionic surface active agent; and (c) 0-30 parts by mass of a glycerin derivative. The composition according to the invention has not only a pesticidal activity but also an ovicidal activity on crop pests, and provides a safe and high pesticidal/ovicidal effect.

Abstract: A method for treatment of virus-based diseases of the skin, in particular, herpes simplex virus type-1 and herpes zoster, which comprises topically administering to the skin of a subject suffering from a virus-based disease of the skin a therapeutically amount of an aqueous, aqueous/alcohol, or natural plant oil extract of dandelion.

Abstract: This disclosure provides generally for antimicrobial compositions and methods of use comprising an anthocyanin, an anthocyanidin or metabolites thereof. Methods for promoting healing of a wound using these compositions are also disclosed. These compositions have broad spectrum antimicrobial activity and are safe for human and animal uses. Further, these compositions are safe for medical uses and industrial uses as antiseptic preparations to reduce or prevent microbial growth.

Abstract: Several embodiments disclosed herein relate to formulations having antimicrobial and/or sanitizing effects, and uses of the same. In particular, the formulations and methods of using same provide, in several embodiments, an immediate and a persistent antimicrobial effect against a broad spectrum of microorganisms.

Abstract: The invention relates to pet food compositions designed to induce the animal to cease feeding upon consumption of the appropriate nutritional amount. The invention further provides methods of inducing satiety response in animals and methods of controlling the amount of food intake in animals.

Abstract: Compositions and methods for maintaining healthy skin and alleviating skin conditions such as redness, inflammation, irritation and skin aging, as well as for maintaining healthy scalp and hair are disclosed. The oral compositions disclosed comprise antioxidants including lycopene, gallic acid and ascorbic acid. Preferably lycopene has been water-extracted, more preferably under acid conditions. In the method of treatment aspect of the invention, an oral composition containing antioxidant(s) is administered to a person concurrently with a topical treatment for said skin conditions. Preferred topical compositions comprise cyclohexane polyols, such as cyclohexanediol or cyclohexanetriol.

Abstract: Treatment compositions which impart a microbicidal benefit to treated surfaces which compositions comprise (or in certain preferred embodiments may consist essentially of, or may consist of) as constituents: a zinc source material which releases zinc ions into the treatment composition, preferably a source of Zn++ ions; at least one lower alkyl monohydric alcohol (preferably at least about 25% wt.

Abstract: A display panel includes a EL panel part, a CF panel part, and a resin layer. Light is extracted from a luminous part including an organic luminous layer in the EL panel part in a direction of an arrow. The resin layer is formed to cover an upper surface of the EL panel part. Transmittance of the light from the EL panel part is 80% or higher. The resin layer includes a resin part and a plurality of particles dispersed in the resin part. The particles are formed of synthetic zeolite having a refractive-index ratio to the resin part of 1.0 or more and a particle size of 2 ?m or more.

Abstract: The present invention pertains to a composition for preventing, decreasing and/or treating skin and hair/coat disorders, such as is effected by inflammatory reactions, environmental factors, ageing or cancer. In particular, the present invention relates to the use of flavanones compounds or their derivatives in nutritional, cosmetic or pharmaceutical compositions for improvement of human or pet animal skin and coat conditions.

Abstract: A powdered mixture that may be added to the water or food of animals. The powder comprises a mixture, which includes brewer's yeast, Aronia extract, cranberry extract, and an omega-3 fatty acid (such as docosahexaenoic acid (DHA)). In some embodiments, the mixture of the powder also includes one or more of the following: an added amount of citric acid, potassium chloride, tricalcium phosphate, water-soluble egg membrane complex, an added amount of vitamin E, a meat flavor agent (such as natural bacon flavor), and other suitable ingredients.

Abstract: The present invention relates to an extract of a processed herbal medicinal plant and a composition for skin external application which contains the extract. More specifically, the composition for skin external application contains an extract of processed herbal medicinal plant, prepared through a method comprising the steps of: (a) processing an herbal medicinal plant by a process of boiling, steaming, roasting, baking or heating the medicinal plant or a combination of two or more of these processes; (b) obtaining an extract of the processed medicinal plant. The composition shows an improved antioxidant effect.

Abstract: Disclosed herein is a method for treating an androgen-stimulated disease in a subject in need thereof by administering to the subject a composition containing an effective amount of an inhibitor of I?B kinase subunit ? activity. The composition can also be administered to a subject at high risk for prostate cancer as a method for reducing the subject's risk thereof. A further method relates to identifying a modulator of transcriptional activity regulated by I?B kinase subunit ?. Still another method relates to determining the I?B kinase subunit ?-regulated transcriptional activity regulated by in a non-human mammalian test subject.

Abstract: Curcuma aromatica essential oil is blue-black dark liquid with camphoraceous, woody, amber and spicy characteristic odor and is less valued in market, however the prepared value added products have very good shining color with the improved fragrance.

Abstract: One exemplary embodiment of the disclosure provides methods and compositions for treating a subject suffering from Alcoholic Liver Disease, Non-Alcoholic Fatty Liver Disease, type 2 diabetes, metabolic syndrome, cardiovascular disease, chronic kidney disease, and certain cancers, or a combination thereof, by administering a therapeutically effective amount of purified liminoid glucoside or a pharmaceutically acceptable salt thereof to the subject.

Abstract: A bioluminescence imaging-based high-throughput assay for inhibitors of ABCG2 is described. Compositions of inhibitors of ABCG2 and methods of using ABCG2 inhibitors are also described.

Abstract: Systems and methods of weight management and compositions or formulations useful therein are disclosed and described.

Abstract: The present invention relates to phytosanitary compositions with fungicidal properties that comprise a mixture of essential oils obtained from plants and agents with known fungicidal properties, such as alkali metal or ammonium bicarbonates, and compounds based on copper or the salts thereof, for use, principally, in contact-protection against fungal infections in cultivated plants and post-harvest, and also in other antifungal applications. In said compositions, the effect of the agents that have known fungicidal properties is potentiated synergistically by the aforementioned essential oils. The present invention also relates to the use of said essential oils as potentiators for agents with known fungicidal properties.

Abstract: The invention provides a deterioration inhibitor containing an amount of a product obtained by treatment of a tea extract with an oxidizing enzyme and then inactivating the enzyme. Addition of a deterioration inhibiting material according to the invention to a food or beverage or a cosmetic can inhibit deterioration of flavor and fragrance, with use in smaller amounts than conventional deterioration inhibitors. A particularly notable effect is exhibited against production of p-cresol and p-methylacetophenone which are citral-derived deterioration odor components, and therefore it is suitable for foods and beverages or cosmetics with citral-containing citrus-like flavors and fragrances.

Abstract: The present invention relates generally to methods of extraction and processing of polymethoxylated flavone (“PMF”) powder from Ortanique peels for commercial application.

Abstract: A water-soluble anti-inflammatory cream is disclosed. The cream is a composition of between about 7.5% and about 30% by weight of a healing oil; between about 1% and about 6% by weight of an herbal extract; between about 0% and about 3.5% by weight of microencapsulated amino acids; and at least 39.4% by weight water.

Abstract: The present disclosure in general relates to a process for (1) reducing impurities, i.e. undesirable natural components such as waxes and undesirable synthetic materials such as agrochemicals and other environmental pollutants, or (2) fractionation of natural components present in an essential oil using at least one selective membrane.

Abstract: A non-toxic composition for the treatment and prevention of ectoparasite infestations is provided. In its most basic form, the composition comprises a combination of effective amounts of cinnamon oil, oregano oil and either citronella oil or lavender oil. Additional oils, including both citronella oil and lavender oil, in addition to peppermint oil, orange oil, tea tree oil and rosemary oil may be added to the composition while still maintaining the efficacy of the composition. The composition may be combined with a carrier agent and the combination may be applied to a subject to effect the elimination of ectoparasites and the prevention of new infestations. Preferably, the carrier agent is a shampoo, a conditioner, a non-aqueous spray, a body wash or a lotion.

Abstract: A treatment protocol for use in the treatment of neurocutaneous syndrome is described and comprises at least one xanthone component, which may comprise at least one mangosteen component, and at least one detoxification component. Additional embodiments comprise at least one herbal component, at least one vitamin component, or a combination thereof. A method of treating a patient having neurocutaneous syndrome is described herein and comprises: providing at least one xanthone component, which may comprise at least one mangosteen component, providing at least one xanthone component, which may comprise at least one mangosteen component, to the patient, and administering the at least one detoxification component to the patient. Additional methods steps may include providing and administering at least one herbal component, providing and administering at least one vitamin component or a combination thereof.

Abstract: Compositions for promoting hair growth can be formed using food related oils. The food related oils include meadowfoam seed oil, neem oil, sesame oil, camelina, flaxeed oil, and tamanu oil. The oil can be combined with lime peel essential oil and/or aloe vera to create various products. The products in an oil for treating the hair and scalp, a treatment for damaged hair and scalp, shampoo, conditioner, pomade and hair root stimulant. A method for making each product is described. In addition, a method for using each product is described.

Abstract: The present invention relates to a synthetic solid bar cleanser formulated to clean human skin. More particularly, the present invention relates to synthetic solid cleanser formulations which have pH of about 5.5, the same as human skin, and yet which perform similarly, or superior, to traditional soap.

Abstract: The present invention relates to topical compositions containing fermented extracts of Traditional Chinese Medicinal (TCM) ingredients for improving the appearance and skin condition of the user. The topical compositions of the present invention are tailored for different users of different skin compositions according to TCM principles. The fermented TCM extracts are characterized by reduced odor and/or color in comparison with unfermented TCM extracts and are therefore more suitable for use in cosmetic products.

Abstract: The invention of the present application provides a natural material derived from Swinglea glutinosa leaves that in combination with low doses of pyrethroids, maintains the effect of high doses of pyrethroids over mites. The material derived from Swinglea glutinosa leaves, in a preparation with pyrethroids, results in a mix material with the potential to lower the doses of synthetic pyrethroids, eliminating the need to use high doses of synthetic pesticides for acari control.

Abstract: An insect repellent compound that includes naturally occurring oil that emits an odor which repels insects is described. The compound is not harmful to animals, to humans or to the environment. The compound may be incorporated into materials such as yarn that is woven to form a mesh. The material may be used for making an animal mask, for screen doors and other applications. A method of making the compound and incorporating it into materials and products is described.

Abstract: A topical, over the counter, all natural, organic, antifungal, antibacterial cream having superior moisturizing and water repellency performance that absorbs into the epidermis without spreading thereby eliminating and preventing the growth of the rash-causing fungus that causes diaper rash, and other skin irritation rashes.