Containing Or Obtained From Ginkgo (e.g., Ginkgo Biloba, Maidenhair, Etc.) Patents (Class 424/752)
  • Patent number: 10441616
    Abstract: The present invention provides a compound having an effect of preventing and/or treating the damage or degeneration of cochlear (and vestibular) mother cells and spiral ganglion neurons by downregulating a cysteinyl leukotriene receptor. Particularly, the present invention provides a composition for preventing or treating sensorineural hearing loss, containing a cysteinyl leukotriene receptor and a Ginkgo biloba extract as active ingredients, on the basis of the co-administration of a cysteinyl leukotriene receptor and a Ginkgo biloba extract having an excellent effect of protecting hearing.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: October 15, 2019
    Assignee: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Sang Myun Park, Jung Sub Park, Yun Hoon Choung, Yeon Ju Kim
  • Patent number: 10441599
    Abstract: Provided is a pharmaceutical composition containing ginkgolide B and the blood platelet prostaglandin cyclooxygenase inhibitor aspirin, a method for preparation of the pharmaceutical composition and a use thereof. When used together, ginkgolide B and aspirin have a synergistic effect in resisting platelet aggregation.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: October 15, 2019
    Assignee: CHENGDU BAIYU PHARMACEUTICAL CO., LTD
    Inventor: Yi Sun
  • Patent number: 10287261
    Abstract: The present invention provides vortioxetine pyroglutamate salt and pharmaceutical compositions comprising said salt.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: May 14, 2019
    Assignee: H. Lundbeck A/S
    Inventors: Heidi Lopez de Diego, Kim Lasse Christensen, Rene Holm, Jens Kateb
  • Patent number: 10265317
    Abstract: In one aspect, the invention relates to compositions comprising at least one creatine or creatine analog, at least one omega-3 fatty acid, and citicoline analogs. Also disclosed are methods of using same, alone or in combination with other agents, to treat depression disorders and associated maladies. Also disclosed are methods of using same, alone or in combination with other agents, to improve neuropsychological performance. Also disclosed are methods of using same, alone or in combination with other agents, to improve complexion. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: April 23, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Perry Renshaw, Deborah Yurgelun-Todd
  • Patent number: 10058552
    Abstract: In one aspect, the invention relates to compositions comprising at least one creatine or creatine analog, at least one omega-3 fatty acid, and citicoline analogs. Also disclosed are methods of using same, alone or in combination with other agents, to treat depression disorders and associated maladies. Also disclosed are methods of using same, alone or in combination with other agents, to improve neuropsychological performance. Also disclosed are methods of using same, alone or in combination with other agents, to improve complexion. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: August 28, 2018
    Assignee: University of Utah Research Foundation
    Inventors: Perry Renshaw, Deborah Yurgelun-Todd
  • Patent number: 10058533
    Abstract: A pharmaceutical composition containing ginkgolide B and an Xa factor inhibitor xaban, a preparation method and use of the pharmaceutical composition, wherein the xaban is selected from Rivaroxaban, Apixaban, Edoxaban, Razaxaban and Otamixaban.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: August 28, 2018
    Assignee: CHENGDU BAIYU PHARMACEUTICAL CO., LTD
    Inventor: Yi Sun
  • Patent number: 10028986
    Abstract: The present invention relates to an improved multistep method for the production of an extract of Ginkgo biloba leaves for use as a drug.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: July 24, 2018
    Assignee: Dr. Willmar Schwabe GMBH & Co., KG
    Inventors: Frank Waimer, Steffen Reinhard, Hermann Hauer
  • Patent number: 10028991
    Abstract: The present invention relates to a composition, and methods of using the composition, for minimizing the harmful effects associated with alcohol consumption. The composition includes a plurality of ingredients, which when combined, have the unexpected effect of increasing one or more metabolic pathways in the individual. As the metabolic rate is increased, alcohol is burned off, or utilized as energy source, and occurs at a considerably much faster rate than under normal physiological means. It is believed that the composition may have an effect on the brain causing it to increase metabolic rates. By administering the composition to an inebriated individual, the rate at which a person sobers up, occurs at a faster rate than would occur under normal physiological time frames.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: July 24, 2018
    Assignee: GDB Patent Holdings, LLC
    Inventor: Gregory Blackman
  • Patent number: 9592261
    Abstract: The invention relates to a plant extract combination of ginkgo and ginseng which is effective especially in a (synergistic) over-additive manner and optionally comprises whitethorn extract. Ginseng is used in the form of an ethanol/ethanol/water extract while ginkgo is used in the form of an acetone/acetone-water extract, for example, and the active extracts are prepared at specific quantitative ratios, particularly <1.1:1, thus unexpectedly boosting the prevention or also the treatment of a decline in the mental capacity related to age or also other disorders.
    Type: Grant
    Filed: September 9, 2008
    Date of Patent: March 14, 2017
    Assignee: Dr. Willmar Schwabe GmbH & Co. KG
    Inventors: Rolf D. Beutler, Karlheinz Schmidt
  • Patent number: 9504270
    Abstract: Process for removing pesticides from Ginkgo biloba extracts, which involves submitting an extract obtained by conventional methods to the following steps: a. Liquid-liquid extraction of the extract to obtain a medium polarity fraction containing ginkgo terpenes and pesticides not removable with hexane, and a high polarity fraction containing ginkgo flavone glycosides; b. crystallization from the medium polarity fraction obtained at step a) to give an intermediate with a ginkgolide content of not less than 50%; c. crystallization from the residual solution obtained at step b) to give an intermediate with a bilobalide content of not less than 50%; d. mixing of the high polarity fraction obtained at step a) with the ginkgo terpene intermediate and the bilobalide intermediate obtained at steps b) and c).
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: November 29, 2016
    Assignee: INDENA S.P.A.
    Inventors: Andrea Giori, Giacomo Mombelli, Sabrina Arpini, Mario Acerbi
  • Patent number: 9034399
    Abstract: Dietary compositions are disclosed herein. For example, dietary compositions containing a combination of a phosphatidylserine, DHA, EPA, antioxidants, and Ginkgo Biloba are provided.
    Type: Grant
    Filed: January 2, 2009
    Date of Patent: May 19, 2015
    Assignee: Melaleuca, Inc.
    Inventors: Alexander B. Rabovsky, Jennifer Kelsey, Jeremy Ivie
  • Publication number: 20150132280
    Abstract: A human dietary supplement comprises theacrine and optionally other compounds that modulate the effects of theacrine. Uses for the theacrine-containing supplement include improvement of at least one of mood, energy, focus, concentration or sexual desire or a reduction of at least one of anxiety or fatigue.
    Type: Application
    Filed: November 12, 2014
    Publication date: May 14, 2015
    Applicant: ORTHO-NUTRA, LLC
    Inventors: Hector L Lopez, Shawn Wells, Tim N. Ziegenfuss
  • Publication number: 20150125542
    Abstract: A Tie2 activator containing, as an active ingredient, a hawthorn extract, a starfruit extract, a shellflower extract, a lotus extract, a rooibos extract, an Indian date extract, a Chinese quince extract, a Psidium guava extract, a long pepper extract, a Quillaja extract, a Kouki extract, a ginkgo extract, an oyster extract, a turmeric extract, a chrysanthemum extract, a jujube extract, a Chinese wolfberry extract, a chamomile extract, or a Butcher's Broom extract, or any combination thereof.
    Type: Application
    Filed: January 13, 2015
    Publication date: May 7, 2015
    Inventors: Nobuaki OHTO, Akinori KISO
  • Publication number: 20150099015
    Abstract: Methods and compositions are provided for treating neuropsychiatric disorders such as schizophrenia, depression, attention deficit disorder, mild cognitive impairment, dementia, and bipolar disorder. The methods entail administering to a patient diagnosed as having a neuropsychiatric disorder (e.g., schizophrenia, depression, attention deficit disorder, mild cognitive impairment, dementia bipolar disorder, etc.) or as at risk for a neuropsychiatric disorder a benzoic acid, benzoic acid salt, and/or benzoic acid derivative, and/or a sorbic acid, sorbic acid salt, and/or sorbic acid derivative, in combination with a neuropharmacological agent (e.g., an antipsychotic, an antidepressant, medications for attention deficit and hyperactivity disorder, cognitive impairment, or dementia, etc.) where the benzoic acid, benzoic acid salt, or benzoic acid derivative, and/or a sorbic acid, sorbic acid salt, and/or sorbic acid derivative, is in an amount sufficient to increase the efficacy of the neuropharmacological agent.
    Type: Application
    Filed: November 24, 2014
    Publication date: April 9, 2015
    Inventor: Guochuan Emil TSAI
  • Patent number: 8986758
    Abstract: Disclosed are: a method for extracting a traditional herbal medicine component comprising a process in which a traditional oriental medicine component is steamed together with polished rice; and a composition for an external application to skin comprising an extract which has been extracted by means of the method. The component extracted by means of the extraction method reduces the cytotoxicity of the traditional oriental medicine, is recognized as being effective in alleviating skin irritation, and exhibits an outstanding skin-whitening effect.
    Type: Grant
    Filed: November 17, 2010
    Date of Patent: March 24, 2015
    Assignee: Amorepacific Corporation
    Inventors: Dong Hyun Kim, Ji Seong Kim, Hui Kyeung Chang, Duck Hee Kim, Han Kon Kim
  • Publication number: 20150072012
    Abstract: A highly bioavailable, water soluble, sustained release nanoformulation comprising a hydrophobic plant derived compound(s) in an emulsifier phase, and aqueous phase. The formulation provides sustained release of the hydrophobic plant derived compound(s) over a 24 hr time period. A process for preparation of the water soluble nanoformulation is described.
    Type: Application
    Filed: November 13, 2014
    Publication date: March 12, 2015
    Inventors: Ravichandran SRIPATHY, Venkata Narasimha Siva Rama Raju MANDAPATI, Gopaal AJAY, Nirvanashetty SOMASHEKARA, Ramchand Nanappan CHANIYILPARAMPU, Rama Raju GOKARAJU, Ganga Raju GOKARAJU, Kiran BHUPATHIRAJU, Dwarakanath ANJANA
  • Publication number: 20150050367
    Abstract: Provided herein are timosaponin compounds of Formula I, II, III, I?, II? and III?, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are uses of said timosaponin compounds for preparing medicament for the treatment of diseases associated with beta-amyloid in hosts or subjects in need thereof.
    Type: Application
    Filed: April 2, 2013
    Publication date: February 19, 2015
    Inventors: Chiming Che, Laiking Sy, Chunnam Lok
  • Publication number: 20150044311
    Abstract: A method for extracting and separating ginkgolides. The ginkgolides obtained through steps of extraction on a ginkgo leaf, further extraction, column chromatography, crystallization, and crystal mixing comprise 25.0% to 50.0% of bilobalide (C15H18O8), 20.0% to 45.0% of ginkgolide A (C20H24O9), 10.0% to 30.0% of ginkgolide B (C20H24O10), and 5.0% to 15.0% of ginkgolide C (C20H24O11). The total quantity of the bilobalide, the ginkgolide A, the ginkgolide B, and the ginkgolide C is over 95%.
    Type: Application
    Filed: October 23, 2014
    Publication date: February 12, 2015
    Inventors: Yi SUN, Yonghong ZHU, Zhengbing TONG, Jie WANG
  • Publication number: 20150044306
    Abstract: A process for fractionating a plant material to provide isolated extractives, the process includes pretreating the plant material to provide a fluidized plant material, subjecting the pretreated fluidized plant material to high frequency pulses and shear forces without denaturing bioactive aspects of one or more components of the plant material to provide a first liquid fraction having extractives to be isolated and a first fractionated plant material, separating the first liquid fraction having extractives from the first fractionated plant material, and isolating extractives from the first liquid fraction.
    Type: Application
    Filed: August 8, 2014
    Publication date: February 12, 2015
    Inventors: Melvin Mitchell, James Etson Brandenburg, JR.
  • Publication number: 20150024041
    Abstract: The current invention is a supplement made from a combination of herbs, vitamins, amino acids which in the preferred embodiment is a 100% vegetarian liquid capsules that are ingested allow for rapid absorption. The components of the supplement can be mint or menthol such as peppermint or spearmint, Methyl B12 or B12, Niacin, Guarana, Dimethylaminoethanol, Acetyl-L-carnitine or ALCAR, Ocimum tenuiflorum, one or more teas such as green tea, white tea or black tea, Ginkgo, Rhodiola rosea, phosphatidylserine, Tyrosine, L-Alpha Glycerylphosphorylcholine, Citicoline (INN), Huperzine A, and Vinpocetine.
    Type: Application
    Filed: October 6, 2014
    Publication date: January 22, 2015
    Inventor: Shaahin Cheyene
  • Publication number: 20140322198
    Abstract: The invention relates to an active ingredient and/or to a composition having beneficial effect on neurological and cognitive functions.
    Type: Application
    Filed: November 29, 2012
    Publication date: October 30, 2014
    Inventors: Sybille Buchwald-Werner, Hajime Fujii
  • Patent number: 8865687
    Abstract: The present invention relates to a preparation suitable for the prevention and/or treatment of vascular disorders, comprising the following fractions: fraction a) consisting of long chain polyunsaturated fatty acids; fraction b) consisting of phospholipids, which fraction contains at least two different phospholipids selected from the group consisting of phosphatidylserine, phosphatidylinositol, phosphatidylcholine and phosphatidylethanolamine. fraction c) consisting of compounds which are a factor in methionine metabolism, which fraction contains at least one member selected from the group consisting of folic acid, vitamin B12, vitamin B6, magnesium and zinc.
    Type: Grant
    Filed: February 14, 2013
    Date of Patent: October 21, 2014
    Assignee: N.V. Nutricia
    Inventors: Amanda Johanne Kiliaan, Robert Johan Joseph Hageman
  • Patent number: 8840937
    Abstract: A method and composition for reducing the recovery time for a human suffering from mild traumatic brain injury are provided. The composition is a mixture of component supplements that synergistically address the symptoms of the condition and the damage done by the injury.
    Type: Grant
    Filed: February 29, 2012
    Date of Patent: September 23, 2014
    Inventor: Walter Joe Ford, Jr.
  • Publication number: 20140271844
    Abstract: Compositions, dietary supplement compositions, and topical compositions including activated fatty acids and methods for using activated fatty acids to treat a variety of diseases.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Inventor: Raymond A. Miller
  • Publication number: 20140271953
    Abstract: Methods of using extracts of Melicope to impart anti-lipid benefits to skin and/or improve skin conditions resulting from an over-production of lipids.
    Type: Application
    Filed: December 11, 2012
    Publication date: September 18, 2014
    Applicant: AVON PRODUCTS, INC.
    Inventors: Cheng S. Hwang, Uma Santhanam, Jola Idkowiak Baldys, John W. Lyga
  • Publication number: 20140227352
    Abstract: A herbal composition comprising extracts or particulate material from the plants Epimedium Grandiflorum, Turnera diffusa var. aphrodisiaca, Ilex paraguariensis, and Sarsaparilla with an admixture of an emulsifying agent and a dispersing agent serves as a female aphrodisiac herbal composition, in particular for women suffering from lack of sexual desire and arousal disorders.
    Type: Application
    Filed: February 12, 2013
    Publication date: August 14, 2014
    Applicant: EJENDOMSSELSKABET KORSGADE 13
    Inventor: Torben Sogaard-Andersen
  • Patent number: 8765196
    Abstract: Disclosed is a method for separating and purifying Ginkgolide C from root bark of ginkgo.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: July 1, 2014
    Assignee: Guizhou University
    Inventors: Jun He, Jichuan Kang, Jianian Yang, Yixin Qian
  • Publication number: 20140170211
    Abstract: The disclosure provides compositions treating traumatic brain injuries such as concussions. In one embodiment, the composition comprises phosphatidylserine, phosphatidylcholine, quercetin, astaxanthin, R-alpha lipoic acid, N-acetyl cysteine, taurine, L-glutamine, carnitine, D-ribose, creatine, epigallocatechin gallate, melatonin, ginkgo leaf extract, curcumin and L-glycine. The disclosure also provides methods for treating traumatic brain injuries such as concussions by administering an effective amount of the compositions described within.
    Type: Application
    Filed: December 18, 2012
    Publication date: June 19, 2014
    Inventors: Matthew Bennett, Gus Peller
  • Publication number: 20140127328
    Abstract: The present invention relates to methods and compositions for reducing distress dysfunction, including emotional and physical distress. The invention entails co-administration of at least one Receptor Switcher and at least one Endorphin Enhancer. Additionally, at least one Synergistic Enhance and/or at least one Exogenous Opioid are also administered to enhance or prolong the therapeutic effects.
    Type: Application
    Filed: November 5, 2013
    Publication date: May 8, 2014
    Applicant: PONDERA BIOTECHNOLOGIES INC.
    Inventors: Steven Crain, William E. Crain, Stanley M. Crain, Michael Crain
  • Patent number: 8709515
    Abstract: The method comprises steps of: providing a nutraceutical including, in combination, 1.13 to 3 mg lutein and 18.8 to 51.2 mg omega fatty acids and 1.9 to 5.2 mg grape seed extract and 1.9 to 5.2 mg alpha lipoic acid; determining the weight of each dose of the components in the combination based upon an amount per kg body weight of the animal patients; and administering 1 dose of nutraceutical per day to animals suffering from ocular health issues including any degenerative retinal disease and diabetic cataracts and prior to and following cataract surgery for the diminishment and prevention of secondary cataracts.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: April 29, 2014
    Inventors: Carmen C. H. Colitz, Terri L. McCalla, Debra A. Smith
  • Publication number: 20140057007
    Abstract: Food, particularly a beverage for human consumption, the ingestion of which enhances cognitive processes such as intelligence, memory, creativity and mood, and/or produces energizing effects. Such food is composed of a composition dilutable or diluted in a liquid or semi-liquid solution.
    Type: Application
    Filed: April 27, 2012
    Publication date: February 27, 2014
    Inventor: Marco Zipoli
  • Patent number: 8642099
    Abstract: The present invention relates to an improved multi-step method for preparing an extract from ginkgo biloba having a reduced content of 4?-O-methyl pyridoxine and/or biflavones, wherein the depletion is carried out by filtration over an adsorber resin and/or an ion exchanger and the substances to be removed are retained on the resin. The invention further relates to an extract from ginkgo biloba having a reduced content of 4?-O-methyl pyridoxine and/or biflavones, which is obtainable by the method according to the present invention, as well as to its use.
    Type: Grant
    Filed: July 9, 2008
    Date of Patent: February 4, 2014
    Assignee: Dr. Willmar Schwabe GmbH & Co. KG
    Inventors: Clemens Erdelmeier, Hermann Hauer, Egon Koch, Friedrich Lang
  • Publication number: 20140017219
    Abstract: A composition for treating, ameliorating and/or preventing conditions associated with cognitive decline and/or motor neuron death comprise a fatty acid component enriched for one or more activated fatty acids and a nutraceutically acceptable excipient. A method for treating, ameliorating and/or preventing conditions associated with cognitive decline and/or motor neuron death includes administering a fatty acid component enriched for one or more activated fatty acids.
    Type: Application
    Filed: September 19, 2013
    Publication date: January 16, 2014
    Applicant: Nitromega Corp.
    Inventor: Raymond A. Miller
  • Publication number: 20140010900
    Abstract: The invention relates to a pharmaceutical composition containing active vegetable substances and a mixture made of a polymeric water-soluble and a polymeric water-insoluble matrix forming agent. Said pharmaceutical composition is suitable for the oral administration of active vegetable substances with delayed release.
    Type: Application
    Filed: December 21, 2011
    Publication date: January 9, 2014
    Applicants: MAX ZELLER SÖHNE AG, MEPHA SCHWEIZ AG
    Inventor: Marco Spitz
  • Patent number: 8613961
    Abstract: A dermatological cream includes between about 8% and about 25% by weight of a healing oil; between about 3% and about 8% by weight of an herbal extract; between about 0.1% and about 0.6% by weight of vitamin E; a microencapsulated ingredient selected from the group consisting of: about 0.6% by weight capsaicin, between about 2% and about 2.5% by weight capsiscum, about 6% by weight methylsulfonylmethane, about 2% by weight collagen peptides, about 5% by weight azealic acid, between about 2% and about 15% by weight ibuprofen, between about 4% and about 10% by weight sulfur, between about 2% and about 15% by weight zinc oxide, between about 5% and about 8% by weight vitamin C, between about 0.5% and about 1% by weight vitamin A, between about 4% and about 8% by weight menthol, between about 3% and about 6% by weight camphor, about 0.5% by weight nicotinic acid, between about 3% and about 5% by weight amino acids, and between about 3% and about 6% by weight tea tree oil; and at least 43.4% by weight water.
    Type: Grant
    Filed: January 9, 2013
    Date of Patent: December 24, 2013
    Assignee: NU Technology, LLC
    Inventors: Irina V Filippova, Leonid K. Filippov
  • Publication number: 20130337093
    Abstract: The invention relates to a method for providing an awaking effect and specifically affecting post lunch dip in a subject comprising providing a subject with a composition comprising an isolate of guarana plant, and at least one of (i) isolate of ginkgo biloba plant or functional analogue thereof and (ii) fruit sugars, wherein the composition does not affect the subject's heart activity. The invention further provides a method for affecting post lunch dip in a subject, comprising administering to the subject a daily dose of a composition comprising (i) an isolate of guarana plant, (ii) an isolate of ginkgo biloba plant or functional analogue thereof and (iii) fruit sugars for a period of at least 7 days.
    Type: Application
    Filed: June 13, 2013
    Publication date: December 19, 2013
    Inventor: Eli FARAGGI
  • Publication number: 20130316024
    Abstract: A cosmetic kit and the use thereof for improving the appearance of the skin is described. Further described, is the prevention and/or controlling of cellulite or the orange peel syndrome and/or for slimming down the figure, through the increase of the elasticity and firmness of the skin by stepping up collagen synthesis, for increasing blood microcirculation and for improving thermoregulation of the skin.
    Type: Application
    Filed: November 18, 2011
    Publication date: November 28, 2013
    Applicant: RHODIA POLIAMIDA E ESPECIALIDADES LTDA
    Inventors: Gabriel Gorescu, Thomas Canova, Tarcis Cordeiro Bastos, Karla Laguens
  • Patent number: 8591965
    Abstract: The use of Ginkgo complexed with phosphatidylserine for the manufacture of a medicament or a dietary supplement for the enhancement of cognitive function and alleviation of mental fatigue, i.e. to improve the speed of memory and memory quality, to increase accuracy and attention in activities in normal healthy subjects, to prevent deterioration of the speed and quality of memory in people with decreased cognitive functions, to counteract cognitive fatigue, and also having an influence on the mood, particularly in healthy children, young adults, middle-aged and/or old people. It is further provided the use of the Ginkgo-phosphatidylserine complex for the treatment and prevention of disease related with decreased cognitive function and increased mental fatigue such as Dementia, and Alzheimer's Disease.
    Type: Grant
    Filed: January 26, 2005
    Date of Patent: November 26, 2013
    Assignee: Indena S.p.A.
    Inventors: Paolo Morazzoni, Orlando Petrini, Andrew Scholey, David Kennedy
  • Publication number: 20130266638
    Abstract: Compositions are disclosed which have as a component thereof an inhibitor of the enzymatic production of 3-deoxyglucosone (3DG) from fructoselysine and/or an inactivator of 3DG, and which are useful for the treatment or prophylaxis of a condition or disease state that is alleviated by inhibiting such 3DG production. Methods of using such compositions, e.g., for improving the appearance, texture and/or elasticity of aging skin, are also disclosed.
    Type: Application
    Filed: June 3, 2013
    Publication date: October 10, 2013
    Inventors: Annette Tobia, Alice Marcy, Bangying Su, Takeshi Niwa
  • Publication number: 20130263298
    Abstract: A transgenic fly whose genome is modified to express enhanced levels of glutamate-cysteine ligase (GCL) gene is provided. The fly displays phenotypes associated with Alzheimer's disease (AD). Further, a method for diagnosing AD is provided, which includes assessing enzymatic activities in mitochondrial enzymes. Glutathione pathway are investigated by creating Alzheimer's model Drosophila with over-expression of the GCLc gene, inducing redox stress through sleep deprivation, and analyzing mitochondrial electron transport chain (ETC) using colorimetric enzymatic assays. For prevention of AD, it is proposed that the epigenetic approaches be used to increase glutathione levels in vivo before the onset of AD. For treatment of AD, it is proposed that the glutathione levels be increased by GCLc modulation.
    Type: Application
    Filed: March 27, 2013
    Publication date: October 3, 2013
    Applicant: INDIGO CAPITAL GROUP LLC
    Inventors: Lisa P. MICHAELS, Tess P. Michaels
  • Publication number: 20130259952
    Abstract: A Tie2 activator containing, as an active ingredient, a hawthorn extract, a starfruit extract, a shellflower extract, a lotus extract, a rooibos extract, an Indian date extract, a Chinese quince extract, a Psidium guava extract, a long pepper extract, a Quillaja extract, a Kouki extract, a ginkgo extract, an oyster extract, a turmeric extract, a chrysanthemum extract, a jujube extract, a Chinese wolfberry extract, a chamomile extract, or a Butcher's Broom extract, or any combination thereof.
    Type: Application
    Filed: May 30, 2013
    Publication date: October 3, 2013
    Inventors: Nobuaki OHTO, Akinori KISO
  • Patent number: 8545810
    Abstract: Disclosed herein are compositions and methods for treating a variety of mood and behavioral disorders, including attention deficit hyperactivity disorder (ADHD), anxiety, depression, memory loss, as well as other conditions. Also disclosed herein are methods for diagnosing certain conditions, such as ADHD, using these compositions.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: October 1, 2013
    Inventor: Jef Gazley
  • Publication number: 20130224318
    Abstract: The present invention describes methods for improving the appearance of skin, particularly, treating, ameliorating, preventing, delaying, and/or improving one or more signs of excess accumulation and/or production of subcutaneous fat, such as cellulite, and conditions related thereto, by topically applying compositions comprising Carnitine Palmitoyl Transferase-1 (CPT-1) modulators, optionally with other anti-lipid agents; and also describes compositions and methods for treating, preventing and improving the appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating loss of subcutaneous fat in the skin, wherein the compositions include natural plant constituents that stimulate lipid synthesis.
    Type: Application
    Filed: February 26, 2013
    Publication date: August 29, 2013
    Applicant: Avon Products, Inc.
    Inventor: Avon Products, Inc.
  • Patent number: 8501162
    Abstract: A composition for the prevention or inhibition of free radical-induced effect on the skin and/or hair comprises at least three antioxidant agents selected from the group consisting of ginkgo extract, emblica extract, dimethylmethoxy chromanol, pine bark extract, and rosemary extract.
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: August 6, 2013
    Assignee: The Boots Company PLC
    Inventors: Stephen Peter Barton, Mark Johnson, Paul James Tomlinson
  • Publication number: 20130189380
    Abstract: The invention discloses herbal ingredients derived from Sphaeranthus indicus standardized to at least one frullanolide/eudesmanoid sesquiterpene compound and their compositions as natural energy enhancer to provide an onset and steady maintenance of energy and mental alertness in a mammal. The invention further includes the use of ingredients and compositions for food ingredient formulations such as dietary supplement, food ingredient, beverage, snack or energy drink containing the above said herbal ingredient(s) for enhancing physical activity, physical fitness, mental alertness, enhancing energy levels, stamina levels, circulatory health, blood vessel health and for better mental health in warm blooded animal.
    Type: Application
    Filed: March 11, 2013
    Publication date: July 25, 2013
    Applicant: LAILA NUTRACEUTICALS
    Inventor: Laila Nutraceuticals
  • Publication number: 20130189382
    Abstract: Use of fucoxanthin in the preparation of a product having neuroprotective effect associated with neurodegenerative disorder and improving memory is disclosed in the disclosure. A product having neuroprotective effect associated with neurodegenerative disorder is also disclosed in the disclosure. Fucoxanthin can inhibit oxidative stress of cells and has the effect of preventing or treating Alzheimer's disease and improving memory.
    Type: Application
    Filed: September 30, 2010
    Publication date: July 25, 2013
    Applicant: Beijing Gingko Group Biological Technology Co., Ltd.
    Inventors: Yanmei Li, Liang Li
  • Patent number: 8486460
    Abstract: Compositions and methods are provided for lowering blood pressure, lowering blood sugar, lowering cholesterol, prevent stroke, removing age spots, curing stroke, or enlarging blood vessels to remove the toxins from the blood. In one embodiment, the composition comprises the herbal extracts of liquorice root, self-heal, mulberry leaves, chrysanthemum, ginkgo nuts, mangosteen, maltose and dextrin. The composition is used as a nutraceutical treatment to lower likelihood of stroke.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: July 16, 2013
    Inventor: Katharine Lai
  • Publication number: 20130171120
    Abstract: This invention relates to a composition that contains quercetin, vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B12, vitamin C, caffeine, epigallocatechin gallate, epicatechin, epicatechin gallate, and epigallocatechin.
    Type: Application
    Filed: November 16, 2012
    Publication date: July 4, 2013
    Applicant: THE FRS COMPANY
    Inventor: THE FRS COMPANY
  • Patent number: 8475849
    Abstract: A formulation for well-being in humans including: extracts from the herbal varieties, Polygonum multiflorum, Panax quinquefolium, Gingko biloba, and Equisetum arvense; beta sitosterol methyl sulfonyl methane; soy isoflavones; levo-arginine; inositol; niacin; pantothenic acid or salts thereof; alpha-tocopherol; biotin; pyridoxine hydrochloride zinc (or amino acid chelate thereof); and colostrum.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: July 2, 2013
    Assignee: Dolphst Pty Ltd.
    Inventor: Jon Phillips
  • Publication number: 20130129844
    Abstract: The present invention relates to a sterile and/or decontaminated composition for topical use, including hyaluronic acid at a concentration of greater than or equal to 0.1 wt % relative to the total weight of the composition, at least one skin wound healing agent, optionally at least one plant extract, and at least one solvent. The invention also relates to a unit including such a composition, to a method for preparing such a composition, and to the uses thereof.
    Type: Application
    Filed: July 28, 2011
    Publication date: May 23, 2013
    Applicant: HORUS PHARMA
    Inventors: Claude Claret, Martine Claret, Carole Gard