Abstract: Provision of a material, which has activity of inhibiting endothelin-converting enzyme and is effective for skin whitening or antihypertension. An endothelin-converting enzyme inhibitor comprising, as an active ingredient, at least one selected from the group consisting of Hiptage candicans, Piper sarmentosum, Solanum stramonifolium, Anaxagorea luzonensis, Smilax corbularia, Ardisia elliptica, Erythrina suberosa, Dactyloctenium aegyptium, Hopea ferrea and extracts thereof.

Abstract: This document provides dietary supplement compositions. For example, dietary supplement compositions having an acetylcholinesterase inhibitor (e.g., huperzine A), a Bacopa monnieri extract, acetyl-L-carnitine or acetyl CoA, and a curcuminoid (e.g., curcumin) are provided.

Abstract: Described and disclosed herein are various embodiments of systems, devices, components and methods configured to deliver a two-dimensional acoustic coordinated reset neuromodulation therapy to a patient's auditory cortex. A novel auditory stimulation regime is employed, where suitably configured therapeutic signals that take into account the patient's tinnitus frequency and periodicity are employed to excite areas surrounding the center of tinnitus excitation in the patient's auditory cortex.

Abstract: Disclosed is a Chinese medicinal composition prepared from the following medical raw materials in parts by weight: 1 part of ginseng, 0.8-1.5 parts of ginkgo leaf and 0.018-0.030 part of stigma croci.

Abstract: Ophthalmic nutraceutical composition comprising: vitamins; trace elements; carotenoids; omega-3 fatty acids; and resveratrol.

Abstract: A method for the prevention and/or treatment of dementia in a human subject; the method comprising the step of administering an effective amount of a composition comprising at least one carotenoid selected from the group consisting of lutein, zeaxanthin and meso-zeaxanthin; and a composition comprising at least one omega-3 fatty acid.

Abstract: The present invention provides a compound having an effect of preventing and/or treating the damage or degeneration of cochlear (and vestibular) mother cells and spiral ganglion neurons by downregulating a cysteinyl leukotriene receptor. Particularly, the present invention provides a composition for preventing or treating sensorineural hearing loss, containing a cysteinyl leukotriene receptor and a Ginkgo biloba extract as active ingredients, on the basis of the co-administration of a cysteinyl leukotriene receptor and a Ginkgo biloba extract having an excellent effect of protecting hearing.

Abstract: Provided is a pharmaceutical composition containing ginkgolide B and the blood platelet prostaglandin cyclooxygenase inhibitor aspirin, a method for preparation of the pharmaceutical composition and a use thereof. When used together, ginkgolide B and aspirin have a synergistic effect in resisting platelet aggregation.

Abstract: The present invention provides vortioxetine pyroglutamate salt and pharmaceutical compositions comprising said salt.

Abstract: In one aspect, the invention relates to compositions comprising at least one creatine or creatine analog, at least one omega-3 fatty acid, and citicoline analogs. Also disclosed are methods of using same, alone or in combination with other agents, to treat depression disorders and associated maladies. Also disclosed are methods of using same, alone or in combination with other agents, to improve neuropsychological performance. Also disclosed are methods of using same, alone or in combination with other agents, to improve complexion. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A pharmaceutical composition containing ginkgolide B and an Xa factor inhibitor xaban, a preparation method and use of the pharmaceutical composition, wherein the xaban is selected from Rivaroxaban, Apixaban, Edoxaban, Razaxaban and Otamixaban.

Abstract: In one aspect, the invention relates to compositions comprising at least one creatine or creatine analog, at least one omega-3 fatty acid, and citicoline analogs. Also disclosed are methods of using same, alone or in combination with other agents, to treat depression disorders and associated maladies. Also disclosed are methods of using same, alone or in combination with other agents, to improve neuropsychological performance. Also disclosed are methods of using same, alone or in combination with other agents, to improve complexion. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present invention relates to a composition, and methods of using the composition, for minimizing the harmful effects associated with alcohol consumption. The composition includes a plurality of ingredients, which when combined, have the unexpected effect of increasing one or more metabolic pathways in the individual. As the metabolic rate is increased, alcohol is burned off, or utilized as energy source, and occurs at a considerably much faster rate than under normal physiological means. It is believed that the composition may have an effect on the brain causing it to increase metabolic rates. By administering the composition to an inebriated individual, the rate at which a person sobers up, occurs at a faster rate than would occur under normal physiological time frames.

Abstract: The present invention relates to an improved multistep method for the production of an extract of Ginkgo biloba leaves for use as a drug.

Abstract: The invention relates to a plant extract combination of ginkgo and ginseng which is effective especially in a (synergistic) over-additive manner and optionally comprises whitethorn extract. Ginseng is used in the form of an ethanol/ethanol/water extract while ginkgo is used in the form of an acetone/acetone-water extract, for example, and the active extracts are prepared at specific quantitative ratios, particularly <1.1:1, thus unexpectedly boosting the prevention or also the treatment of a decline in the mental capacity related to age or also other disorders.

Abstract: Process for removing pesticides from Ginkgo biloba extracts, which involves submitting an extract obtained by conventional methods to the following steps: a. Liquid-liquid extraction of the extract to obtain a medium polarity fraction containing ginkgo terpenes and pesticides not removable with hexane, and a high polarity fraction containing ginkgo flavone glycosides; b. crystallization from the medium polarity fraction obtained at step a) to give an intermediate with a ginkgolide content of not less than 50%; c. crystallization from the residual solution obtained at step b) to give an intermediate with a bilobalide content of not less than 50%; d. mixing of the high polarity fraction obtained at step a) with the ginkgo terpene intermediate and the bilobalide intermediate obtained at steps b) and c).

Abstract: Dietary compositions are disclosed herein. For example, dietary compositions containing a combination of a phosphatidylserine, DHA, EPA, antioxidants, and Ginkgo Biloba are provided.

Abstract: A human dietary supplement comprises theacrine and optionally other compounds that modulate the effects of theacrine. Uses for the theacrine-containing supplement include improvement of at least one of mood, energy, focus, concentration or sexual desire or a reduction of at least one of anxiety or fatigue.

Abstract: A Tie2 activator containing, as an active ingredient, a hawthorn extract, a starfruit extract, a shellflower extract, a lotus extract, a rooibos extract, an Indian date extract, a Chinese quince extract, a Psidium guava extract, a long pepper extract, a Quillaja extract, a Kouki extract, a ginkgo extract, an oyster extract, a turmeric extract, a chrysanthemum extract, a jujube extract, a Chinese wolfberry extract, a chamomile extract, or a Butcher's Broom extract, or any combination thereof.

Abstract: Methods and compositions are provided for treating neuropsychiatric disorders such as schizophrenia, depression, attention deficit disorder, mild cognitive impairment, dementia, and bipolar disorder. The methods entail administering to a patient diagnosed as having a neuropsychiatric disorder (e.g., schizophrenia, depression, attention deficit disorder, mild cognitive impairment, dementia bipolar disorder, etc.) or as at risk for a neuropsychiatric disorder a benzoic acid, benzoic acid salt, and/or benzoic acid derivative, and/or a sorbic acid, sorbic acid salt, and/or sorbic acid derivative, in combination with a neuropharmacological agent (e.g., an antipsychotic, an antidepressant, medications for attention deficit and hyperactivity disorder, cognitive impairment, or dementia, etc.) where the benzoic acid, benzoic acid salt, or benzoic acid derivative, and/or a sorbic acid, sorbic acid salt, and/or sorbic acid derivative, is in an amount sufficient to increase the efficacy of the neuropharmacological agent.

Abstract: Disclosed are: a method for extracting a traditional herbal medicine component comprising a process in which a traditional oriental medicine component is steamed together with polished rice; and a composition for an external application to skin comprising an extract which has been extracted by means of the method. The component extracted by means of the extraction method reduces the cytotoxicity of the traditional oriental medicine, is recognized as being effective in alleviating skin irritation, and exhibits an outstanding skin-whitening effect.

Abstract: A highly bioavailable, water soluble, sustained release nanoformulation comprising a hydrophobic plant derived compound(s) in an emulsifier phase, and aqueous phase. The formulation provides sustained release of the hydrophobic plant derived compound(s) over a 24 hr time period. A process for preparation of the water soluble nanoformulation is described.

Abstract: Provided herein are timosaponin compounds of Formula I, II, III, I?, II? and III?, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are uses of said timosaponin compounds for preparing medicament for the treatment of diseases associated with beta-amyloid in hosts or subjects in need thereof.

Abstract: A method for extracting and separating ginkgolides. The ginkgolides obtained through steps of extraction on a ginkgo leaf, further extraction, column chromatography, crystallization, and crystal mixing comprise 25.0% to 50.0% of bilobalide (C15H18O8), 20.0% to 45.0% of ginkgolide A (C20H24O9), 10.0% to 30.0% of ginkgolide B (C20H24O10), and 5.0% to 15.0% of ginkgolide C (C20H24O11). The total quantity of the bilobalide, the ginkgolide A, the ginkgolide B, and the ginkgolide C is over 95%.

Abstract: A process for fractionating a plant material to provide isolated extractives, the process includes pretreating the plant material to provide a fluidized plant material, subjecting the pretreated fluidized plant material to high frequency pulses and shear forces without denaturing bioactive aspects of one or more components of the plant material to provide a first liquid fraction having extractives to be isolated and a first fractionated plant material, separating the first liquid fraction having extractives from the first fractionated plant material, and isolating extractives from the first liquid fraction.

Abstract: The current invention is a supplement made from a combination of herbs, vitamins, amino acids which in the preferred embodiment is a 100% vegetarian liquid capsules that are ingested allow for rapid absorption. The components of the supplement can be mint or menthol such as peppermint or spearmint, Methyl B12 or B12, Niacin, Guarana, Dimethylaminoethanol, Acetyl-L-carnitine or ALCAR, Ocimum tenuiflorum, one or more teas such as green tea, white tea or black tea, Ginkgo, Rhodiola rosea, phosphatidylserine, Tyrosine, L-Alpha Glycerylphosphorylcholine, Citicoline (INN), Huperzine A, and Vinpocetine.

Abstract: The invention relates to an active ingredient and/or to a composition having beneficial effect on neurological and cognitive functions.

Abstract: The present invention relates to a preparation suitable for the prevention and/or treatment of vascular disorders, comprising the following fractions: fraction a) consisting of long chain polyunsaturated fatty acids; fraction b) consisting of phospholipids, which fraction contains at least two different phospholipids selected from the group consisting of phosphatidylserine, phosphatidylinositol, phosphatidylcholine and phosphatidylethanolamine. fraction c) consisting of compounds which are a factor in methionine metabolism, which fraction contains at least one member selected from the group consisting of folic acid, vitamin B12, vitamin B6, magnesium and zinc.

Abstract: A method and composition for reducing the recovery time for a human suffering from mild traumatic brain injury are provided. The composition is a mixture of component supplements that synergistically address the symptoms of the condition and the damage done by the injury.

Abstract: Compositions, dietary supplement compositions, and topical compositions including activated fatty acids and methods for using activated fatty acids to treat a variety of diseases.

Abstract: Methods of using extracts of Melicope to impart anti-lipid benefits to skin and/or improve skin conditions resulting from an over-production of lipids.

Abstract: A herbal composition comprising extracts or particulate material from the plants Epimedium Grandiflorum, Turnera diffusa var. aphrodisiaca, Ilex paraguariensis, and Sarsaparilla with an admixture of an emulsifying agent and a dispersing agent serves as a female aphrodisiac herbal composition, in particular for women suffering from lack of sexual desire and arousal disorders.

Abstract: Disclosed is a method for separating and purifying Ginkgolide C from root bark of ginkgo.

Abstract: The disclosure provides compositions treating traumatic brain injuries such as concussions. In one embodiment, the composition comprises phosphatidylserine, phosphatidylcholine, quercetin, astaxanthin, R-alpha lipoic acid, N-acetyl cysteine, taurine, L-glutamine, carnitine, D-ribose, creatine, epigallocatechin gallate, melatonin, ginkgo leaf extract, curcumin and L-glycine. The disclosure also provides methods for treating traumatic brain injuries such as concussions by administering an effective amount of the compositions described within.

Abstract: The present invention relates to methods and compositions for reducing distress dysfunction, including emotional and physical distress. The invention entails co-administration of at least one Receptor Switcher and at least one Endorphin Enhancer. Additionally, at least one Synergistic Enhance and/or at least one Exogenous Opioid are also administered to enhance or prolong the therapeutic effects.

Abstract: The method comprises steps of: providing a nutraceutical including, in combination, 1.13 to 3 mg lutein and 18.8 to 51.2 mg omega fatty acids and 1.9 to 5.2 mg grape seed extract and 1.9 to 5.2 mg alpha lipoic acid; determining the weight of each dose of the components in the combination based upon an amount per kg body weight of the animal patients; and administering 1 dose of nutraceutical per day to animals suffering from ocular health issues including any degenerative retinal disease and diabetic cataracts and prior to and following cataract surgery for the diminishment and prevention of secondary cataracts.

Abstract: Food, particularly a beverage for human consumption, the ingestion of which enhances cognitive processes such as intelligence, memory, creativity and mood, and/or produces energizing effects. Such food is composed of a composition dilutable or diluted in a liquid or semi-liquid solution.

Abstract: The present invention relates to an improved multi-step method for preparing an extract from ginkgo biloba having a reduced content of 4?-O-methyl pyridoxine and/or biflavones, wherein the depletion is carried out by filtration over an adsorber resin and/or an ion exchanger and the substances to be removed are retained on the resin. The invention further relates to an extract from ginkgo biloba having a reduced content of 4?-O-methyl pyridoxine and/or biflavones, which is obtainable by the method according to the present invention, as well as to its use.

Abstract: A composition for treating, ameliorating and/or preventing conditions associated with cognitive decline and/or motor neuron death comprise a fatty acid component enriched for one or more activated fatty acids and a nutraceutically acceptable excipient. A method for treating, ameliorating and/or preventing conditions associated with cognitive decline and/or motor neuron death includes administering a fatty acid component enriched for one or more activated fatty acids.

Abstract: The invention relates to a pharmaceutical composition containing active vegetable substances and a mixture made of a polymeric water-soluble and a polymeric water-insoluble matrix forming agent. Said pharmaceutical composition is suitable for the oral administration of active vegetable substances with delayed release.

Abstract: A dermatological cream includes between about 8% and about 25% by weight of a healing oil; between about 3% and about 8% by weight of an herbal extract; between about 0.1% and about 0.6% by weight of vitamin E; a microencapsulated ingredient selected from the group consisting of: about 0.6% by weight capsaicin, between about 2% and about 2.5% by weight capsiscum, about 6% by weight methylsulfonylmethane, about 2% by weight collagen peptides, about 5% by weight azealic acid, between about 2% and about 15% by weight ibuprofen, between about 4% and about 10% by weight sulfur, between about 2% and about 15% by weight zinc oxide, between about 5% and about 8% by weight vitamin C, between about 0.5% and about 1% by weight vitamin A, between about 4% and about 8% by weight menthol, between about 3% and about 6% by weight camphor, about 0.5% by weight nicotinic acid, between about 3% and about 5% by weight amino acids, and between about 3% and about 6% by weight tea tree oil; and at least 43.4% by weight water.

Abstract: The invention relates to a method for providing an awaking effect and specifically affecting post lunch dip in a subject comprising providing a subject with a composition comprising an isolate of guarana plant, and at least one of (i) isolate of ginkgo biloba plant or functional analogue thereof and (ii) fruit sugars, wherein the composition does not affect the subject's heart activity. The invention further provides a method for affecting post lunch dip in a subject, comprising administering to the subject a daily dose of a composition comprising (i) an isolate of guarana plant, (ii) an isolate of ginkgo biloba plant or functional analogue thereof and (iii) fruit sugars for a period of at least 7 days.

Abstract: A cosmetic kit and the use thereof for improving the appearance of the skin is described. Further described, is the prevention and/or controlling of cellulite or the orange peel syndrome and/or for slimming down the figure, through the increase of the elasticity and firmness of the skin by stepping up collagen synthesis, for increasing blood microcirculation and for improving thermoregulation of the skin.

Abstract: The use of Ginkgo complexed with phosphatidylserine for the manufacture of a medicament or a dietary supplement for the enhancement of cognitive function and alleviation of mental fatigue, i.e. to improve the speed of memory and memory quality, to increase accuracy and attention in activities in normal healthy subjects, to prevent deterioration of the speed and quality of memory in people with decreased cognitive functions, to counteract cognitive fatigue, and also having an influence on the mood, particularly in healthy children, young adults, middle-aged and/or old people. It is further provided the use of the Ginkgo-phosphatidylserine complex for the treatment and prevention of disease related with decreased cognitive function and increased mental fatigue such as Dementia, and Alzheimer's Disease.

Abstract: Compositions are disclosed which have as a component thereof an inhibitor of the enzymatic production of 3-deoxyglucosone (3DG) from fructoselysine and/or an inactivator of 3DG, and which are useful for the treatment or prophylaxis of a condition or disease state that is alleviated by inhibiting such 3DG production. Methods of using such compositions, e.g., for improving the appearance, texture and/or elasticity of aging skin, are also disclosed.

Abstract: A Tie2 activator containing, as an active ingredient, a hawthorn extract, a starfruit extract, a shellflower extract, a lotus extract, a rooibos extract, an Indian date extract, a Chinese quince extract, a Psidium guava extract, a long pepper extract, a Quillaja extract, a Kouki extract, a ginkgo extract, an oyster extract, a turmeric extract, a chrysanthemum extract, a jujube extract, a Chinese wolfberry extract, a chamomile extract, or a Butcher's Broom extract, or any combination thereof.

Abstract: A transgenic fly whose genome is modified to express enhanced levels of glutamate-cysteine ligase (GCL) gene is provided. The fly displays phenotypes associated with Alzheimer's disease (AD). Further, a method for diagnosing AD is provided, which includes assessing enzymatic activities in mitochondrial enzymes. Glutathione pathway are investigated by creating Alzheimer's model Drosophila with over-expression of the GCLc gene, inducing redox stress through sleep deprivation, and analyzing mitochondrial electron transport chain (ETC) using colorimetric enzymatic assays. For prevention of AD, it is proposed that the epigenetic approaches be used to increase glutathione levels in vivo before the onset of AD. For treatment of AD, it is proposed that the glutathione levels be increased by GCLc modulation.

Abstract: Disclosed herein are compositions and methods for treating a variety of mood and behavioral disorders, including attention deficit hyperactivity disorder (ADHD), anxiety, depression, memory loss, as well as other conditions. Also disclosed herein are methods for diagnosing certain conditions, such as ADHD, using these compositions.

Abstract: The present invention describes methods for improving the appearance of skin, particularly, treating, ameliorating, preventing, delaying, and/or improving one or more signs of excess accumulation and/or production of subcutaneous fat, such as cellulite, and conditions related thereto, by topically applying compositions comprising Carnitine Palmitoyl Transferase-1 (CPT-1) modulators, optionally with other anti-lipid agents; and also describes compositions and methods for treating, preventing and improving the appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating loss of subcutaneous fat in the skin, wherein the compositions include natural plant constituents that stimulate lipid synthesis.

Abstract: A composition for the prevention or inhibition of free radical-induced effect on the skin and/or hair comprises at least three antioxidant agents selected from the group consisting of ginkgo extract, emblica extract, dimethylmethoxy chromanol, pine bark extract, and rosemary extract.